MCID: RHM001
MIFTS: 54

Rheumatic Fever

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Rheumatic Fever

Summaries for Rheumatic Fever

NIH Rare Diseases : 50 rheumatic fever is an inflammatory condition that may develop after infection with group a streptococcus bacteria, such as strep throat or scarlet fever. it is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. it is not clear why some people who are infected with group a streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. treatment usually includes antibiotics and/or anti-inflammatory medications. last updated: 1/11/2015

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to choreatic disease and uveitis, and has symptoms including chorea, migraine and fatigue. An important gene associated with Rheumatic Fever is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Methotrexate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotype is immune system.

Wikipedia : 72 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
id Related Disease Score Top Affiliating Genes
1 choreatic disease 31.5 CD40LG HP TNF
2 uveitis 30.1 CD40LG TNF
3 aseptic meningitis 30.0 HLA-DRB1 TLR2 TNF
4 gastric ulcer 29.8 IL2 TLR2 TNF
5 rheumatoid arthritis 29.0 CD40LG HLA-DRB1 IL2 TLR2 TNF
6 systemic lupus erythematosus 28.0 CD40LG FCN3 HLA-DRB1 IL2 MBL2 TNF
7 rheumatic fever-related antigen 12.2
8 sydenham chorea 11.6
9 rheumatic myocarditis 11.5
10 rheumatic encephalitis 11.0
11 aortic valve disease 2 10.9
12 biemond syndrome 10.8 HLA-DRB1 TNF
13 migraine with brainstem aura 10.8 HLA-DRB1 TNF
14 mosaic trisomy 1 10.8 HLA-DRB1 TNF
15 autoimmune retinopathy 10.8 HLA-DRB1 TNF
16 epstein-barr virus hepatitis 10.8 HLA-DRB1 TNF
17 anencephaly and spina bifida x-linked 10.8 HLA-DRB1 TNF
18 limb-body wall complex 10.7 HLA-DRB1 TNF
19 scirrhous adenocarcinoma 10.7 IL2 TNF
20 walker dyson syndrome 10.7 MBL2 TNF
21 tracheal calcification 10.7 MBL2 TNF
22 moved to 244450 10.7 HLA-DRB1 TNF
23 kernicterus due to isoimmunization 10.7 HLA-DRB1 TNF
24 autoimmune polyglandular syndrome type 3 10.7 IL2 TNF
25 bipolar i disorder 10.7 MYOM2 TNF
26 riboflavin transporter deficiency 10.7 HLA-DRB1 TNF
27 anthracosilicosis 10.7 HLA-DRB1 IL2
28 hemangioma of orbit 10.7 IL2 TNF
29 reese retinal dysplasia 10.7 HLA-DRB1 IL2
30 epidermolysis bullosa simplex, weber-cockayne type 10.7 MASP2 MBL2
31 plantar wart 10.6 IL2 TNF
32 antigen-peptide-transporter 2 deficiency 10.6 TLR2 TNF
33 prothrombin thrombophilia 10.6 MBL2 TLR2
34 amyotrophic lateral sclerosis type 10 10.6 IL2 TNF
35 halal setton wang syndrome 10.6 TLR2 TNF
36 lung disease 10.6 CD40LG TNF
37 submandibular gland disease 10.6 CD40LG TNF
38 trichosporonosis 10.6 TLR2 TNF
39 tinea favosa 10.6 IL2 TNF
40 uterine ligament papillary cystadenoma 10.6 CD40LG MYOM2
41 imperforate oropharynx-costo vetebral anomalies 10.6 CD40LG MBL2
42 heart disease 10.6
43 rheumatic heart disease 10.6
44 generalized atherosclerosis 10.6 CD40LG MYOM2
45 parametritis 10.6 IL2 TNF
46 acute hemorrhagic encephalitis 10.6 CD40LG MYOM2
47 chronic lymphocytic leukemia 10.5 HLA-DRB1 HP
48 phlyctenulosis 10.5 MBL2 TNF
49 mycobacterium kansasii 10.5 TLR2 TNF
50 temporal arteritis 10.5 CD40LG MYOM2

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Human phenotypes related to Rheumatic Fever:

32 (show all 34)
id Description HPO Frequency HPO Source Accession
1 chorea 32 frequent (33%) HP:0002072
2 migraine 32 occasional (7.5%) HP:0002076
3 fatigue 32 frequent (33%) HP:0012378
4 constipation 32 occasional (7.5%) HP:0002019
5 pericarditis 32 occasional (7.5%) HP:0001701
6 arthritis 32 hallmark (90%) HP:0001369
7 epistaxis 32 occasional (7.5%) HP:0000421
8 arrhythmia 32 frequent (33%) HP:0011675
9 fever 32 frequent (33%) HP:0001945
10 respiratory insufficiency 32 occasional (7.5%) HP:0002093
11 abdominal pain 32 frequent (33%) HP:0002027
12 nephrotic syndrome 32 occasional (7.5%) HP:0000100
13 fasciculations 32 occasional (7.5%) HP:0002380
14 chest pain 32 frequent (33%) HP:0100749
15 arthralgia 32 frequent (33%) HP:0002829
16 gait disturbance 32 occasional (7.5%) HP:0001288
17 erythema 32 occasional (7.5%) HP:0010783
18 myocarditis 32 frequent (33%) HP:0012819
19 pallor 32 frequent (33%) HP:0000980
20 dyslexia 32 occasional (7.5%) HP:0010522
21 anorexia 32 hallmark (90%) HP:0002039
22 sinusitis 32 frequent (33%) HP:0000246
23 nausea and vomiting 32 hallmark (90%) HP:0002017
24 behavioral abnormality 32 occasional (7.5%) HP:0000708
25 subcutaneous nodule 32 hallmark (90%) HP:0001482
26 aplasia/hypoplasia of the abdominal wall musculature 32 occasional (7.5%) HP:0010318
27 abnormality of the aortic valve 32 frequent (33%) HP:0001646
28 abnormality of the pleura 32 occasional (7.5%) HP:0002103
29 abnormality of the mitral valve 32 frequent (33%) HP:0001633
30 dysgraphia 32 occasional (7.5%) HP:0010526
31 macule 32 hallmark (90%) HP:0012733
32 hemiballismus 32 occasional (7.5%) HP:0100248
33 endocarditis 32 frequent (33%) HP:0100584
34 recurrent pharyngitis 32 frequent (33%) HP:0100776

MGI Mouse Phenotypes related to Rheumatic Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD40LG FCN1 HP IL2 MASP2 MBL2

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Rivaroxaban Approved Phase 3 366789-02-8
5
Warfarin Approved Phase 3 81-81-2 6691 54678486
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9
Phytonadione Approved, Nutraceutical Phase 3 84-80-0 4812 5284607
10 Antimetabolites Phase 3
11 Antimetabolites, Antineoplastic Phase 3
12 Antirheumatic Agents Phase 3
13 Dermatologic Agents Phase 3
14 Folic Acid Antagonists Phase 3
15 Immunosuppressive Agents Phase 3
16 Nucleic Acid Synthesis Inhibitors Phase 3
17 Vitamin B Complex Phase 3
18 Analgesics Phase 3
19 Analgesics, Non-Narcotic Phase 3
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Gastrointestinal Agents Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
24 Natriuretic Peptide, Brain Phase 2, Phase 3
25 HIV Protease Inhibitors Phase 3,Phase 2
26
protease inhibitors Phase 3,Phase 2
27 Anticoagulants Phase 3
28 Antifibrinolytic Agents Phase 3
29 Antipyretics Phase 3
30 Antithrombin III Phase 3
31 Antithrombins Phase 3
32 Coagulants Phase 3
33 Cyclooxygenase Inhibitors Phase 3
34 Factor Xa Inhibitors Phase 3
35 Fibrinolytic Agents Phase 3
36 Hemostatics Phase 3
37 Micronutrients Phase 3
38 Platelet Aggregation Inhibitors Phase 3
39 Serine Proteinase Inhibitors Phase 3
40 Trace Elements Phase 3
41 Vitamins Phase 3
42 Folate Nutraceutical Phase 3
43 Vitamin B9 Nutraceutical Phase 3
44 Menaquinone Nutraceutical Phase 3
45 naphthoquinone Nutraceutical Phase 3
46 serine Nutraceutical Phase 3
47 Vitamin K Nutraceutical Phase 3
48
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
49
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
50 Anti-Bacterial Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 51)

id Name Status NCT ID Phase Drugs
1 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3 Methotrexate;Placebo
2 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
3 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
5 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
6 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
7 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
8 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
9 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
10 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
11 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
12 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
13 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106
14 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
15 Yellow Fever Vaccination Under Low Dose Methotrexate Therapy Unknown status NCT02383680
16 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
17 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
18 41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases Unknown status NCT00000106
19 A Two-step Method Apparently Improved the Physicians' Level of Diagnosis Decision-making for Adult Patients With FUO Unknown status NCT02035670
20 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
21 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
22 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
23 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
24 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341
25 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616
26 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
27 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
28 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
29 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
30 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
31 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Simvastatin
32 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
33 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
34 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524
35 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108
36 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444
37 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Recruiting NCT02926560
38 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments Recruiting NCT01642706
39 Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism Recruiting NCT03076866
40 Rheumatic Heart Disease School Project Recruiting NCT01550068
41 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
42 RhEumatiC Heart diseAse Genetics Recruiting NCT02118818
43 Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients Recruiting NCT03306784
44 Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients Recruiting NCT03095937
45 Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge Recruiting NCT03156972
46 Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever Active, not recruiting NCT03090685
47 Juvenile Inflammatory Rheumatism (JIR) Cohorte Enrolling by invitation NCT02377245
48 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis Not yet recruiting NCT03183180
49 Clinical Audit on the Managment in Assiut University Children Hospital Not yet recruiting NCT03281863
50 Use of Remote Monitoring by Smartphone in the Care Management of Patients With Rheumatoid Arthritis Not yet recruiting NCT03005925

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

39
Heart, Skin, Brain, Tonsil, B Cells, Bone, Monocytes

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 668)
id Title Authors Year
1
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
2
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
3
Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm Mimicking Acute Rheumatic Fever: Report of an Unusual Clinical Presentation and Review of Literature. ( 28859047 )
2017
4
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
5
Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever. ( 28559267 )
2017
6
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
7
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
8
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
9
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
10
Acute rheumatic fever outbreak in southern central European country. ( 27815733 )
2017
11
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
12
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
13
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
14
Is a rheumatic fever register the best surveillance tool to evaluate rheumatic fever control in the Auckland region? ( 28796771 )
2017
15
Evaluation of vitamin D levels in patients with acute rheumatic fever. ( 28680013 )
2017
16
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
17
Atypical Articular Presentations in Indian Children with Rheumatic Fever. ( 28528779 )
2017
18
Eliminating acute rheumatic fever and rheumatic heart disease. ( 28721865 )
2017
19
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
20
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
21
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017
22
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
23
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
24
Difficulties in the differential diagnosis between Takayasu arteritis and rheumatic fever: case report. ( 27267341 )
2016
25
Long-Term Outcomes From Acute Rheumatic Fever and Rheumatic Heart Disease: A Data-Linkage and Survival Analysis Approach. ( 27407071 )
2016
26
Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 27867464 )
2016
27
Significance of silent carditis and investigation of follow-up signs in acute rheumatic fever. ( 27097234 )
2016
28
Primary Prevention of Rheumatic Fever. ( 27351359 )
2016
29
Nurse-led school-based clinics for rheumatic fever prevention and skin infection management: evaluation of Mana Kidz programme in Counties Manukau. ( 27348871 )
2016
30
Rheumatic Fever: a neglected and underdiagnosed disease. New perspective on diagnosis and prevention. ( 27982273 )
2016
31
Rheumatic fever and rheumatic heart disease in Bangladesh: A review. ( 26896274 )
2016
32
2016 National Rheumatic Fever Week: The status of rheumatic heart disease in South Africa. ( 27499394 )
2016
33
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
34
Advanced heart block in acute rheumatic fever. ( 27053901 )
2016
35
An epidemiological study to assess the true incidence and prevalence of rheumatic heart disease and acute rheumatic fever in New Caledonian schoolchildren. ( 27203400 )
2016
36
Sharing success - understanding barriers and enablers to secondary prophylaxis delivery for rheumatic fever and rheumatic heart disease. ( 27581750 )
2016
37
Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever. ( 27774884 )
2016
38
Arterial stiffness during acute and recovery phases of children with rheumatic fever. ( 27130739 )
2016
39
Association between rheumatic fever and Takayasu's arteritis - Case report. ( 27267532 )
2016
40
Acute rheumatic fever and rheumatic heart disease. ( 27228242 )
2016
41
Mitral valve enhancement in a patient with active Rheumatic Fever: An uncommon phenomenon on the MRI examination with possible clinical significance. ( 27878698 )
2016
42
CHANGING CLINICAL PROFILE OF ACUTE RHEUMATIC FEVER AND RHEUMATIC RECURRENCE. ( 27323580 )
2016
43
Administering intramuscular penicillin injections to reduce rheumatic fever. ( 27281906 )
2016
44
Post-Streptococcal Autoimmune Sequelae: Rheumatic Fever and Beyond ( 26866235 )
2016
45
Acute Rheumatic Fever: An Evidence-Based Approach To Diagnosis And Initial Management. ( 27462838 )
2016
46
Cardiac Myosin Epitopes Recognized by Autoantibody in Acute and Convalescent Rheumatic Fever. ( 27273689 )
2016
47
Atypical arthritis revisited: Acute rheumatic fever. ( 27212853 )
2016
48
Junctional tachycardia in a child with non-rheumatic fever streptococcal pharyngitis. ( 27989256 )
2016
49
Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease. ( 27918954 )
2016
50
Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever. ( 27499748 )
2016

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CD40LG FCN1 FCN2 FCN3 HLA-DRB1 HP
2
Show member pathways
12.65 CD40LG HLA-DRB1 IL2 TNF
3
Show member pathways
12.65 IL2 MBL2 TLR2 TNF
4
Show member pathways
12.58 HLA-DRB1 IL2 TLR2 TNF
5
Show member pathways
12.48 CD40LG IL2 TLR2 TNF
6
Show member pathways
12.41 CD40LG HLA-DRB1 IL2 TNF
7
Show member pathways
12.38 HLA-DRB1 IL2 TLR2 TNF
8 12.31 CD40LG IL2 TLR2 TNF
9 12.02 HLA-DRB1 TLR2 TNF
10 11.93 HLA-DRB1 MBL2 TLR2
11
Show member pathways
11.89 CD40LG HLA-DRB1 TLR2 TNF
12
Show member pathways
11.73 IL2 TLR2 TNF
13
Show member pathways
11.68 FCN2 FCN3 MASP2 MBL2
14 11.63 HLA-DRB1 TLR2 TNF
15
Show member pathways
11.53 CD40LG IL2 TNF
16 11.48 CD40LG TLR2 TNF
17
Show member pathways
11.41 CD40LG IL2 TNF
18 11.33 HLA-DRB1 MASP2 MBL2
19 11.23 CD40LG TLR2 TNF
20
Show member pathways
11.18 FCN1 FCN2 FCN3 MASP2 MBL2
21 11.05 HLA-DRB1 IL2
22 11.02 CD40LG IL2 TNF
23 10.81 HLA-DRB1 IL2 TNF

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CD40LG HP IL2 MASP2 MBL2 TNF
2 extracellular region GO:0005576 9.61 CD40LG FCN1 FCN2 FCN3 HP IL2
3 cell surface GO:0009986 9.55 CD40LG HLA-DRB1 MBL2 TLR2 TNF
4 collagen trimer GO:0005581 8.92 FCN1 FCN2 FCN3 MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 FCN1 FCN2 FCN3 HP MASP2 MBL2
2 immune response GO:0006955 9.83 CD40LG HLA-DRB1 IL2 TLR2 TNF
3 innate immune response GO:0045087 9.8 FCN1 FCN2 FCN3 MASP2 MBL2 TLR2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40LG TLR2 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.67 FCN2 MBL2 TLR2 TNF
6 positive regulation of phagocytosis GO:0050766 9.59 MBL2 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.58 TLR2 TNF
8 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG TLR2
9 positive regulation of interleukin-10 production GO:0032733 9.57 CD40LG TLR2
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 TLR2 TNF
11 immune system process GO:0002376 9.56 FCN1 FCN2 FCN3 HLA-DRB1 IL2 MASP2
12 complement activation GO:0006956 9.55 FCN1 FCN2 FCN3 MASP2 MBL2
13 negative regulation of viral entry into host cell GO:0046597 9.54 FCN1 FCN3
14 positive regulation of chemokine production GO:0032722 9.52 TLR2 TNF
15 negative regulation of growth of symbiont in host GO:0044130 9.51 MBL2 TNF
16 opsonization GO:0008228 9.48 FCN2 MBL2
17 regulation of immunoglobulin secretion GO:0051023 9.46 CD40LG TNF
18 recognition of apoptotic cell GO:0043654 9.43 FCN1 FCN2 FCN3
19 positive regulation of interleukin-8 secretion GO:2000484 9.19 FCN1
20 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP2 MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.35 FCN1 FCN2 FCN3 IL2 MBL2
2 calcium-dependent protein binding GO:0048306 9.33 FCN2 MASP2 MBL2
3 tumor necrosis factor receptor binding GO:0005164 9.32 CD40LG TNF
4 signaling pattern recognition receptor activity GO:0008329 9.26 FCN1 TLR2
5 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 HP MASP2 MBL2

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....