MCID: RHM035
MIFTS: 34

Rheumatic Fever-Related Antigen

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Rheumatic Fever-Related Antigen

MalaCards integrated aliases for Rheumatic Fever-Related Antigen:

Name: Rheumatic Fever-Related Antigen 53
Rheumatic Fever 55 69
Acute Rheumatic Fever 55

Characteristics:

Orphanet epidemiological data:

55
rheumatic fever
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult;

OMIM:

53
Inheritance:
? autosomal recessive


Classifications:



External Ids:

OMIM 53 268240
Orphanet 55 ORPHA3099
MESH via Orphanet 42 D012213
UMLS via Orphanet 70 C0035436
ICD10 via Orphanet 33 I00 I01.0 I01.1 more
SNOMED-CT via HPO 65 386661006 50177009

Summaries for Rheumatic Fever-Related Antigen

MalaCards based summary : Rheumatic Fever-Related Antigen, also known as rheumatic fever, is related to rheumatic fever and sydenham chorea, and has symptoms including fever, arthralgia and constipation. The drugs Methotrexate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and b cells.

Description from OMIM: 268240

Related Diseases for Rheumatic Fever-Related Antigen

Diseases related to Rheumatic Fever-Related Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 12.7
2 sydenham chorea 11.9
3 rheumatic myocarditis 11.6
4 acute articular rheumatism 11.4
5 choreatic disease 11.3
6 aortic valve disease 2 11.3
7 rheumatic encephalitis 11.1
8 heart disease 10.7
9 rheumatic heart disease 10.6
10 arthritis 10.4
11 endocarditis 10.3
12 pharyngitis 10.2
13 chorea, childhood-onset, with psychomotor retardation 10.2
14 glomerulonephritis 10.2
15 reactive arthritis 10.2
16 scarlet fever 10.2
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
18 kawasaki disease 10.1
19 acute poststreptococcal glomerulonephritis 10.1
20 atrial standstill 1 10.0
21 aging 10.0
22 subacute bacterial endocarditis 10.0
23 antiphospholipid syndrome 10.0
24 episodic pain syndrome, familial, 1 10.0
25 hydrops, lactic acidosis, and sideroblastic anemia 10.0
26 atrioventricular block 10.0
27 infective endocarditis 10.0
28 pulmonary edema 10.0
29 purpura 10.0
30 systemic lupus erythematosus 9.9
31 septic arthritis 9.9
32 myocarditis 9.9
33 collagen disease 9.9
34 lupus erythematosus 9.9
35 rheumatoid arthritis 9.8
36 osteomyelitis 9.8
37 tonsillitis 9.8
38 fiedler's myocarditis 9.8
39 cardiac tamponade 9.8
40 pericarditis 9.8
41 pyoderma 9.8
42 syncope 9.8
43 autoimmune disease 9.7
44 blood group, i system 9.7
45 gilles de la tourette syndrome 9.7
46 noonan syndrome 1 9.7
47 tetralogy of fallot 9.7
48 takayasu arteritis 9.7
49 heart block, congenital 9.7
50 familial mediterranean fever 9.7

Graphical network of the top 20 diseases related to Rheumatic Fever-Related Antigen:



Diseases related to Rheumatic Fever-Related Antigen

Symptoms & Phenotypes for Rheumatic Fever-Related Antigen

Symptoms via clinical synopsis from OMIM:

53
Immunology:
predisposition to rheumatic fever

Lab:
increased frequency of b cells with 883 antigen


Clinical features from OMIM:

268240

Human phenotypes related to Rheumatic Fever-Related Antigen:

55 31 (show all 37)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 55 31 Frequent (79-30%) HP:0001945
2 arthralgia 55 Frequent (79-30%)
3 constipation 55 Occasional (29-5%)
4 fatigue 55 Frequent (79-30%)
5 chest pain 55 Frequent (79-30%)
6 abdominal pain 55 Frequent (79-30%)
7 nausea and vomiting 55 Very frequent (99-80%)
8 recurrent pharyngitis 55 Frequent (79-30%)
9 macule 55 Very frequent (99-80%)
10 gait disturbance 55 Occasional (29-5%)
11 chorea 55 Frequent (79-30%)
12 respiratory insufficiency 55 Occasional (29-5%)
13 neurological speech impairment 55 Occasional (29-5%)
14 behavioral abnormality 55 Occasional (29-5%)
15 arthritis 55 Very frequent (99-80%)
16 subcutaneous nodule 55 Very frequent (99-80%)
17 arrhythmia 55 Frequent (79-30%)
18 pallor 55 Frequent (79-30%)
19 aplasia/hypoplasia of the abdominal wall musculature 55 Occasional (29-5%)
20 sinusitis 55 Frequent (79-30%)
21 abnormality of the heart valves 55 Occasional (29-5%)
22 abnormality of the aortic valve 55 Frequent (79-30%)
23 abnormality of the pleura 55 Occasional (29-5%)
24 nephrotic syndrome 55 Occasional (29-5%)
25 anorexia 55 Very frequent (99-80%)
26 migraine 55 Occasional (29-5%)
27 abnormality of the immune system 31 HP:0002715
28 erythema 55 Occasional (29-5%)
29 epistaxis 55 Occasional (29-5%)
30 abnormality of the mitral valve 55 Frequent (79-30%)
31 pericarditis 55 Occasional (29-5%)
32 fasciculations 55 Occasional (29-5%)
33 dyslexia 55 Occasional (29-5%)
34 dysgraphia 55 Occasional (29-5%)
35 myocarditis 55 Frequent (79-30%)
36 hemiballismus 55 Occasional (29-5%)
37 endocarditis 55 Frequent (79-30%)

Drugs & Therapeutics for Rheumatic Fever-Related Antigen

Drugs for Rheumatic Fever-Related Antigen (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Rivaroxaban Approved Phase 3 366789-02-8
5
Warfarin Approved Phase 3 81-81-2 54678486 6691
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9
Phytonadione Approved, Investigational, Nutraceutical Phase 3 84-80-0 5284607 4812
10 Antimetabolites Phase 3
11 Antimetabolites, Antineoplastic Phase 3
12 Antirheumatic Agents Phase 3
13 Dermatologic Agents Phase 3
14 Folic Acid Antagonists Phase 3
15 Immunosuppressive Agents Phase 3
16 Nucleic Acid Synthesis Inhibitors Phase 3
17 Vitamin B Complex Phase 3
18 Analgesics Phase 3
19 Analgesics, Non-Narcotic Phase 3
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Gastrointestinal Agents Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
24 Natriuretic Peptide, Brain Phase 2, Phase 3
25 HIV Protease Inhibitors Phase 3,Phase 2
26
protease inhibitors Phase 3,Phase 2
27 Anticoagulants Phase 3
28 Antifibrinolytic Agents Phase 3
29 Antipyretics Phase 3
30 Antithrombin III Phase 3
31 Antithrombins Phase 3
32 Coagulants Phase 3
33 Cyclooxygenase Inhibitors Phase 3
34 Factor Xa Inhibitors Phase 3
35 Fibrinolytic Agents Phase 3
36 Hemostatics Phase 3
37 Micronutrients Phase 3
38 Platelet Aggregation Inhibitors Phase 3
39 Serine Proteinase Inhibitors Phase 3
40 Trace Elements Phase 3
41 Vitamins Phase 3
42 Folate Nutraceutical Phase 3
43 Vitamin B9 Nutraceutical Phase 3
44 Menaquinone Nutraceutical Phase 3
45 naphthoquinone Nutraceutical Phase 3
46 serine Nutraceutical Phase 3
47 Vitamin K Nutraceutical Phase 3
48
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
49
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
50
Penicillin G Approved, Vet_approved Phase 2 61-33-6 5904

Interventional clinical trials:

(show top 50) (show all 51)

# Name Status NCT ID Phase Drugs
1 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3 Methotrexate;Placebo
2 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
3 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
5 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
6 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
7 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
8 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
9 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
10 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
11 Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Not yet recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
12 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
13 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
14 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Not yet recruiting NCT03361163 Phase 1
15 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106
16 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
17 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
18 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
19 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
20 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
21 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
22 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
23 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
24 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341
25 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616
26 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
27 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
28 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
29 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
30 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
31 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Simvastatin
32 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
33 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
34 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108
35 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524
36 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444
37 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Recruiting NCT02926560
38 Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism Recruiting NCT03076866
39 Rheumatic Heart Disease School Project Recruiting NCT01550068
40 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
41 RhEumatiC Heart diseAse Genetics Recruiting NCT02118818
42 Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients Recruiting NCT03306784
43 Sarcopenia in Axial and Peripheral Spondyloarthropathies Recruiting NCT03319264
44 Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients Recruiting NCT03095937
45 Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge Recruiting NCT03156972
46 Juvenile Inflammatory Rheumatism (JIR) Cohorte Enrolling by invitation NCT02377245
47 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis Not yet recruiting NCT03183180
48 Clinical Audit on the Managment in Assiut University Children Hospital Not yet recruiting NCT03281863
49 Fertility Study of Women With Chronic Inflammatory Rheumatism Not yet recruiting NCT03452735
50 Use of Remote Monitoring by Smartphone in the Care Management of Patients With Rheumatoid Arthritis Not yet recruiting NCT03005925

Search NIH Clinical Center for Rheumatic Fever-Related Antigen

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Rheumatic Fever-Related Antigen

Anatomical Context for Rheumatic Fever-Related Antigen

MalaCards organs/tissues related to Rheumatic Fever-Related Antigen:

38
Heart, Bone, B Cells

Publications for Rheumatic Fever-Related Antigen

Articles related to Rheumatic Fever-Related Antigen:

(show top 50) (show all 680)
# Title Authors Year
1
Transition to adult care for Aboriginal children with rheumatic fever: a review informed by a focussed ethnography in northern Australia. ( 29310752 )
2018
2
Rheumatic fever: The rebound phenomenon returns. ( 29411467 )
2018
3
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ( 29440244 )
2018
4
Estimating the likely true changes in rheumatic fever incidence using two data sources. ( 29208066 )
2018
5
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
6
Aboriginal children and penicillin injections for rheumatic fever: how much of a problem is injection pain? ( 29168304 )
2018
7
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. ( 29269013 )
2017
8
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
9
Enablers and barriers to secondary prophylaxis for rheumatic fever among MA8ori aged 14-21 in New Zealand: a framework method study. ( 29149897 )
2017
10
Is a rheumatic fever register the best surveillance tool to evaluate rheumatic fever control in the Auckland region? ( 28796771 )
2017
11
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
12
Using preceding hospital admissions to identify children at risk of developing acute rheumatic fever. ( 29168244 )
2017
13
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
14
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
15
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017
16
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
17
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
18
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
19
Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm Mimicking Acute Rheumatic Fever: Report of an Unusual Clinical Presentation and Review of Literature. ( 28859047 )
2017
20
Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever. ( 28559267 )
2017
21
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
22
Ventricular dyssynchrony as a marker of latent carditis in children with acute rheumatic fever: A tissue Doppler imaging. ( 29067722 )
2017
23
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
24
Eliminating acute rheumatic fever and rheumatic heart disease. ( 28721865 )
2017
25
Atypical Articular Presentations in Indian Children with Rheumatic Fever. ( 28528779 )
2017
26
Evaluation of vitamin D levels in patients with acute rheumatic fever. ( 28680013 )
2017
27
Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. ( 29067978 )
2017
28
Acute rheumatic fever outbreak in southern central European country. ( 27815733 )
2017
29
WhA8nau perceptions and experiences of acute rheumatic fever diagnosis for MA8ori in Northland, New Zealand. ( 29121626 )
2017
30
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
31
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
32
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
33
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
34
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
35
WHAT IS ACUTE RHEUMATIC FEVER (ARF) AND RHEUMATIC HEART DISEASE (RHD)? ( 27132395 )
2016
36
Arterial stiffness during acute and recovery phases of children with rheumatic fever. ( 27130739 )
2016
37
Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever. ( 27499748 )
2016
38
Administering intramuscular penicillin injections to reduce rheumatic fever. ( 27281906 )
2016
39
Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever. ( 27774884 )
2016
40
A Review of Acute Rheumatic Fever and Rheumatic Heart Disease Research in Malaysia. ( 27801390 )
2016
41
An epidemiological study to assess the true incidence and prevalence of rheumatic heart disease and acute rheumatic fever in New Caledonian schoolchildren. ( 27203400 )
2016
42
Advanced heart block in acute rheumatic fever. ( 27053901 )
2016
43
Primary Prevention of Rheumatic Fever. ( 27351359 )
2016
44
Acute Rheumatic Fever with Erythema Marginatum. ( 28002702 )
2016
45
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
46
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
47
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever. ( 27465618 )
2016
48
Post-Streptococcal Autoimmune Sequelae: Rheumatic Fever and Beyond ( 26866235 )
2016
49
Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease. ( 27918954 )
2016
50
Estimating the risk of acute rheumatic fever in New Zealand by age, ethnicity and deprivation. ( 27311633 )
2016

Variations for Rheumatic Fever-Related Antigen

Expression for Rheumatic Fever-Related Antigen

Search GEO for disease gene expression data for Rheumatic Fever-Related Antigen.

Pathways for Rheumatic Fever-Related Antigen

GO Terms for Rheumatic Fever-Related Antigen

Sources for Rheumatic Fever-Related Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....