RA
MCID: RHM011
MIFTS: 94

Rheumatoid Arthritis (RA) malady

Bone diseases, Rare diseases, Respiratory diseases categories

Summaries for Rheumatoid Arthritis

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MedlinePlus:33 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Rheumatoid Arthritis, also known as rheumatoid arthritis, susceptibility to, is related to arthritis and juvenile rheumatoid arthritis, and has symptoms including abnormality of the nervous system, rheumatoid arthritis and abnormality of blood and blood-forming tissues. An important gene associated with Rheumatoid Arthritis is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Lymphocyte Signaling and Hematopoietic cell lineage. The drugs meclofenamate sodium and salsalate and the compounds groalpha and il-12 have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

Genetics Home Reference:22 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

OMIM:46 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex... (180300) more...

CDC:4 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Wikipedia:64 Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints. It... more...

Aliases & Classifications for Rheumatoid Arthritis

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Rheumatoid Arthritis, Aliases & Descriptions:

Name: Rheumatoid Arthritis 31 9 22 46 11 44 33 61
Rheumatoid Arthritis, Susceptibility to 10 23
Arthritis 9 61
Polyarthritis, Rheumatic 9
 
Arthritis, Rheumatoid 22
Atrophic Arthritis 9
Ra 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Respiratory diseases


External Ids:

Disease Ontology9 DOID:7148
ICD9CM28 714.0
MeSH34 D001172
OMIM46 180300
ICD1026 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1233)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis33.9IL17A, IL1A, IL6
2juvenile rheumatoid arthritis33.0IL1A, IL6, HLA-DRB1, SLC11A1
3osteoarthritis32.7CCL2, SAA1, IL1A, CTSK, IL6, IL17A
4systemic lupus erythematosus32.6STAT4
5synovitis32.5IL1A, IL17A, IL6
6psoriatic arthritis32.2IL1A, PTPN22, HLA-DRB1
7pneumonia32.2IL10, CCL2, IL17A, IL6
8periodontitis32.2IL6, IL10, IL17A, CCL2, IL1A
9atherosclerosis32.2IL17A, IL6, CTSK, IL1A, CCL2, CIITA
10tuberculosis32.1IL10, HLA-DRB1, IL17A, CIITA, SLC11A1
11uveitis32.0CCL2, IL17A, IL10, IL1A
12connective tissue disease32.0CCL2, PTPN22, HLA-DRB1, IL10, IL6
13psoriasis31.9IL6, IL10, CIITA, PTPN22, HLA-DRB1, IL1A
14thyroiditis31.8HLA-DRB1, PTPN22, CIITA
15leukemia31.8PADI4, HLA-DRB1, IL1A, BST1, IL17A, IL6
16colitis31.8IL6, IL17A, IL10, IL17RA
17periodontal disease31.8IL17A, IL1A, IL6
18crohn's disease31.7SLC22A4
19lymphopenia31.7PTPN22, CIITA, IL6, IL10
20asthma31.7SLC11A1, IL10, IL17A, HLA-DRB1, STAT4, CCL2
21ulcerative colitis31.6SLC11A1, IL1A, IL6, IL10, IL17A, STAT4
22hepatitis b31.6IL10, HLA-DRB1, IL17A
23diabetes mellitus31.6HLA-DRB1, PTPN22, CCL2, IL6
24hepatitis c31.6HLA-DRB1, CIITA, IL10
25multiple sclerosis31.6CCL2, IL17A, IL10, IL6, SLC11A1, STAT4
26pulmonary fibrosis31.5SERPINH1, CCL2, CTSK
27sepsis31.5CCL2, IL17A, IL10, IL6, CIITA, IL1A
28sarcoidosis31.5IL1A, SLC11A1, HLA-DRB1, CCL2
29gingivitis31.4IL1A, IL17A
30visceral leishmaniasis31.4SLC11A1, IL10
31pulmonary tuberculosis31.4IL10, HLA-DRB1, SLC11A1
32obesity31.4CTSK, CCL2, IL17A, IL6
33atopic dermatitis31.3IL17A, IL10, CCL2, IL1A
34inflammatory bowel disease31.3SLC22A4, IL6, IL10, IL17A, STAT4, SLC11A1
35graves' disease31.3IL1A, FCRL3, PTPN22, HLA-DRB1, CIITA
36pemphigus vulgaris31.3IL1A, HLA-DRB1, CIITA
37septic shock31.2IL10, IL1A, CIITA, IL6
38alopecia areata31.2CIITA, IL1A
39lupus nephritis31.2IL10, CIITA, CCL2
40vascular disease31.2IL10, IL6, IL1A
41leprosy31.1SLC11A1, HLA-DRB1
42allergic asthma31.1IL17A, CCL2, IL10
43chronic obstructive pulmonary disease31.1IL6, CCL2, IL17A
44endometriosis31.0IL17A, CCL2, IL1A, IL6
45ocular cicatricial pemphigoid31.0CIITA
46skin disease31.0IL17A, CIITA, IL10, IL1A
47idiopathic pulmonary fibrosis31.0CCL2, SERPINH1, IL1A
48systemic scleroderma31.0HLA-DRB1, PTPN22, SERPINH1, CCL2, IL17A, IL1A
49encephalitis30.9CCL2, CIITA, IL17A
50brucellosis30.9SLC11A1, SAA1

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Symptoms for Rheumatoid Arthritis

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Symptoms by clinical synopsis from OMIM:

180300

Clinical features from OMIM:

180300

HPO human phenotypes related to Rheumatoid Arthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707
2 rheumatoid arthritis HP:0001370
3 abnormality of blood and blood-forming tissues HP:0001871
4 abnormality of the respiratory system HP:0002086
5 vasculitis HP:0002633
6 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Rheumatoid Arthritis

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Genetic Tests for Rheumatoid Arthritis

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Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis23

Anatomical Context for Rheumatoid Arthritis

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MalaCards organs/tissues related to Rheumatoid Arthritis:

32
T cells, Bone, Monocytes, Endothelial, B cells, Lung, Neutrophil, Skin, Eye, Testes, Bone marrow, Myeloid, Heart, Thyroid, Liver, Pituitary, Kidney, Whole blood, Breast, Lymph node, Spleen, Brain, Salivary gland, Nk cells, Tongue, Thymus, Colon, Retina, Spinal cord, Smooth muscle, Small intestine, Placenta, Prostate, Tonsil

FMA organs/tissues related to Rheumatoid Arthritis:

15
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6SLC11A1, BST1, PTPN22, CIITA, PADI4, STAT4
2MP:000539710.6CCL2, STAT4, PADI4, CIITA, PTPN22, BST1
3MP:000538110.6PTPN22, SERPINH1, CCL2, IL17A, IL10, IL6
4MP:000537610.6PTPN22, CIITA, SAA1, STAT4, CCL2, IL17A
5MP:000538810.5PTPN22, SERPINH1, IL17A, IL17RA, IL10, IL6
6MP:000539010.4CTSK, IL6, IL10, IL17A, CCL2, SERPINH1
7MP:000200610.4CCL2, IL17RA, IL10, IL6, IL1A, SLC11A1
8MP:001076810.3PTPN22, SERPINH1, PADI4, STAT4, CCL2, IL17A
9MP:000537910.2PTPN22, CIITA, STAT4, IL10, IL6, CTSK

Publications for Rheumatoid Arthritis

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Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7254)
idTitleAuthorsYear
1
Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort. (25399388)
2014
2
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
3
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
4
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
5
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
6
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
2013
7
Response to: 'Comorbidities in a Mexican mestizo cohort with established rheumatoid arthritis' by Vega-Morales et al. (24336333)
2013
8
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. (24222719)
2013
9
Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. (23861880)
2013
10
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
11
Evaluation of disease activity indices in Korean patients with rheumatoid arthritis. (21305296)
2012
12
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
13
CIITA is not associated with risk of developing rheumatoid arthritis. (21248776)
2011
14
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
15
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
16
Novel TNF antagonists for the treatment of rheumatoid arthritis. (20001558)
2010
17
Association between the FCGR3A V158F polymorphism and the clinical response to infliximab in rheumatoid arthritis and spondyloarthritis patients. (20560817)
2010
18
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate. (20439295)
2010
19
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
20
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
21
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
22
Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. (19035425)
2008
23
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
24
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
25
Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis. (17265480)
2007
26
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. (17530710)
2007
27
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
28
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
29
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
30
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
31
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
32
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. (15248210)
2004
33
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
34
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
35
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
36
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
37
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
38
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
39
Enrichment of T cells carrying beta7 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. (9779846)
1998
40
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
41
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. (7551660)
1995
42
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. (7818564)
1995
43
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
48
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
49
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Rheumatoid Arthritis

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Clinvar genetic disease variations for Rheumatoid Arthritis:

7
id Gene Name Type Significance SNP ID Assembly Location
1CD244CD244, rs3766379undetermined variantrisk factor
2SLC22A4SLC22A4, IVS1, T-Csingle nucleotide variantrisk factor
3NFKBIL1NFKBIL1, -62T-Asingle nucleotide variantrisk factor
4PTPN22NM_015967.5(PTPN22): c.1858C> T (p.Arg620Trp)single nucleotide variantrisk factorrs2476601GRCh37Chr 1, 114377568: 114377568
5CIITAMHC2TA, -168A-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Rheumatoid Arthritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Rheumatoid Arthritis patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1IGKV4-1immunoglobulin kappa variable 4-1Cartilage+8.770.000
2IGHMimmunoglobulin heavy constant muCartilage+8.020.000
3IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesCartilage+7.600.000
4IGKV1-5immunoglobulin kappa variable 1-5Cartilage+7.450.000
5IGLV2-23immunoglobulin lambda variable 2-23Cartilage+7.410.000
6IGKCimmunoglobulin kappa constantCartilage+7.390.000
7IGLimmunoglobulin lambda locusCartilage+7.150.000
8CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Cartilage-7.130.000
9IGLJ3immunoglobulin lambda joining 3Cartilage+7.050.000
10CXCL13chemokine (C-X-C motif) ligand 13Cartilage+6.450.000
11MMP1matrix metallopeptidase 1 (interstitial collagenase)Cartilage+6.430.000
12IGLV3-19immunoglobulin lambda variable 3-19Cartilage+6.320.000
13POU2AF1POU class 2 associating factor 1Cartilage+6.000.000
14ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideCartilage-5.820.000
15IGHDimmunoglobulin heavy constant deltaCartilage+5.820.000
16NKG7natural killer cell granule protein 7Cartilage+5.650.000
17FOSBFBJ murine osteosarcoma viral oncogene homolog BCartilage-5.350.000
18TNFRSF17tumor necrosis factor receptor superfamily, member 17Cartilage+5.260.000
19SDC1syndecan 1Cartilage+5.260.000
20IGKV3-20immunoglobulin kappa variable 3-20Cartilage+5.230.000
21ANGPTL7angiopoietin-like 7Cartilage-5.080.000
22PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Cartilage-5.070.000
23IGLL3Pimmunoglobulin lambda-like polypeptide 3, pseudogeneCartilage+4.980.000
24CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Cartilage+4.970.000
25IGLV1-40immunoglobulin lambda variable 1-40Cartilage+4.870.000
26FAM107Afamily with sequence similarity 107, member ACartilage-4.850.000
27CD52CD52 moleculeCartilage+4.640.000
28CCL5chemokine (C-C motif) ligand 5Cartilage+4.560.000
29APODapolipoprotein DCartilage-4.400.000
30ADAM28ADAM metallopeptidase domain 28Cartilage+4.120.000
31MXRA5matrix-remodelling associated 5Cartilage+4.100.000
32FKBP5FK506 binding protein 5Cartilage-4.090.002
33PLIN1perilipin 1Cartilage-4.040.000
34DOCK10dedicator of cytokinesis 10Cartilage+4.040.000
35NPAS2neuronal PAS domain protein 2Cartilage-4.010.000
36DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedCartilage-3.910.023
37LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Cartilage+3.890.000
38PTPRCprotein tyrosine phosphatase, receptor type, CCartilage+3.870.000
39NCF1Cneutrophil cytosolic factor 1C pseudogeneCartilage+3.870.000
40MAOAmonoamine oxidase ACartilage-3.850.000
41AQP9aquaporin 9Cartilage+3.840.000
42ZBTB16zinc finger and BTB domain containing 16Cartilage-3.840.000
43ADCY2adenylate cyclase 2 (brain)Cartilage-3.830.000
44TRAF3IP3TRAF3 interacting protein 3Cartilage+3.820.000
45IGKV1D-8immunoglobulin kappa variable 1D-8Cartilage+3.810.000
46IGHG1immunoglobulin heavy constant gamma 1 (G1m marker)Cartilage+3.790.000
47IL32interleukin 32Cartilage+3.790.000
48TOX3TOX high mobility group box family member 3Cartilage-3.780.005
49HLA-DQB1major histocompatibility complex, class II, DQ beta 1Cartilage+3.760.000
50SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DCartilage+3.750.000
51GDF15growth differentiation factor 15Cartilage-3.740.000
52ADAMDEC1ADAM-like, decysin 1Cartilage+3.720.000
53LGALS2lectin, galactoside-binding, soluble, 2Cartilage+3.710.000
54LMOD1leiomodin 1 (smooth muscle)Cartilage-3.650.000
55HLA-DOBmajor histocompatibility complex, class II, DO betaCartilage+3.640.000
56TRHDEthyrotropin-releasing hormone degrading enzymeCartilage-3.610.000
57DPEP2dipeptidase 2Cartilage+3.590.000
58RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated)Cartilage+3.580.000
59HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Cartilage+3.550.030
60TRACT cell receptor alpha constantCartilage+3.480.000
61LEPleptinCartilage-3.480.000
62HK3hexokinase 3 (white cell)Cartilage+3.470.000
63TOP2Atopoisomerase (DNA) II alpha 170kDaCartilage+3.470.000
64LAMP3lysosomal-associated membrane protein 3Cartilage+3.460.000
65MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FCartilage-3.410.000
66TRAT1T cell receptor associated transmembrane adaptor 1Cartilage+3.400.000
67ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideCartilage-3.400.000
68ARHGAP25Rho GTPase activating protein 25Cartilage+3.400.000
69NR4A2nuclear receptor subfamily 4, group A, member 2Cartilage-3.380.000
70MMP13matrix metallopeptidase 13 (collagenase 3)Cartilage+3.370.000
71ADAM12ADAM metallopeptidase domain 12Cartilage+3.370.000
72PLXNC1plexin C1Cartilage+3.360.000
73NFIL3nuclear factor, interleukin 3 regulatedCartilage-3.360.000
74JUNjun proto-oncogeneCartilage-3.340.001
75PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Cartilage-3.330.000
76NDC80NDC80 kinetochore complex componentCartilage+3.320.000
77RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Cartilage+3.310.000
78COL1A1collagen, type I, alpha 1Cartilage+3.300.000
79TIMP4TIMP metallopeptidase inhibitor 4Cartilage-3.290.000
80LCKlymphocyte-specific protein tyrosine kinaseCartilage+3.290.000
81PER1period circadian clock 1Cartilage-3.270.000
82ADIPOQadiponectin, C1Q and collagen domain containingCartilage-3.240.001
83LST1leukocyte specific transcript 1Cartilage+3.230.000
84P2RX5purinergic receptor P2X, ligand-gated ion channel, 5Cartilage+3.220.000
85GAP43growth associated protein 43Cartilage+3.220.000
86FABP4fatty acid binding protein 4, adipocyteCartilage-3.220.000
87LAMA2laminin, alpha 2Cartilage-3.210.000
88TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)Cartilage-3.210.000
89LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1Cartilage+3.200.000
90TRBC1T cell receptor beta constant 1Cartilage+3.200.000
91ATF3activating transcription factor 3Cartilage-3.190.000
92EIF1AYeukaryotic translation initiation factor 1A, Y-linkedCartilage-3.170.023
93SLAMF7SLAM family member 7Cartilage+3.160.000
94RRADRas-related associated with diabetesCartilage-3.150.000
95MYOCmyocilin, trabecular meshwork inducible glucocorticoid responseCartilage-3.140.000
96C7complement component 7Cartilage-3.130.000
97MYH11myosin, heavy chain 11, smooth muscleCartilage-3.130.001
98GADD45Agrowth arrest and DNA-damage-inducible, alphaCartilage-3.120.000
99LIFleukemia inhibitory factorCartilage-3.110.009
100RERGLRERG/RAS-likeCartilage-3.110.000
101GADD45Bgrowth arrest and DNA-damage-inducible, betaCartilage-3.100.000
102LRRC15leucine rich repeat containing 15Cartilage+3.090.000
103RPS4Y1ribosomal protein S4, Y-linked 1Cartilage-3.080.026
104GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Cartilage+3.080.000
105ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Cartilage+3.070.000
106ADMadrenomedullinCartilage-3.070.000
107UCP2uncoupling protein 2 (mitochondrial, proton carrier)Cartilage+3.060.000
108AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Cartilage-3.050.000
109KLF4Kruppel-like factor 4 (gut)Cartilage-3.050.000
110TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Cartilage-3.040.000
111EIF1eukaryotic translation initiation factor 1Cartilage-3.030.003
112AIF1allograft inflammatory factor 1Cartilage+3.030.000
113CORO1Acoronin, actin binding protein, 1ACartilage+3.020.000
114PDK4pyruvate dehydrogenase kinase, isozyme 4Cartilage-3.020.027
115RAMP2receptor (G protein-coupled) activity modifying protein 2Cartilage-3.020.004
116CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Cartilage+3.000.000
117CCDC102Bcoiled-coil domain containing 102BCartilage+3.000.000
118MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2Cartilage-3.000.000
119LEF1lymphoid enhancer-binding factor 1Cartilage+3.000.000
120NOVA1neuro-oncological ventral antigen 1Cartilage-2.980.004
121STAT1signal transducer and activator of transcription 1, 91kDaCartilage+2.960.000
122PTPRCAPprotein tyrosine phosphatase, receptor type, C-associated proteinCartilage+2.960.000
123RRM2ribonucleotide reductase M2Cartilage+2.940.000
124CYR61cysteine-rich, angiogenic inducer, 61Cartilage-2.940.000
125TARPTCR gamma alternate reading frame proteinCartilage+2.930.000
126PPP1R15Aprotein phosphatase 1, regulatory subunit 15ACartilage-2.920.000
127ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)Cartilage+2.910.000
128CEBPDCCAAT/enhancer binding protein (C/EBP), deltaCartilage-2.900.000
129FNDC4fibronectin type III domain containing 4Cartilage-2.890.000
130GFRA2GDNF family receptor alpha 2Cartilage+2.890.000
131FOSL2FOS-like antigen 2Cartilage-2.880.000
132SLC19A2solute carrier family 19 (thiamine transporter), member 2Cartilage-2.870.000
133PTX3pentraxin 3, longCartilage-2.870.007
134SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans)Cartilage+2.850.000
135PLA2G2Dphospholipase A2, group IIDCartilage+2.840.004
136KIF20Akinesin family member 20ACartilage+2.830.000
137CIITAclass II, major histocompatibility complex, transactivatorCartilage+2.830.000
138HLA-DPA1major histocompatibility complex, class II, DP alpha 1Cartilage+2.830.000
139H3F3BH3 histone, family 3B (H3.3B)Cartilage-2.830.000
140OSBPL3oxysterol binding protein-like 3Cartilage+2.820.000
141LTBlymphotoxin beta (TNF superfamily, member 3)Cartilage+2.820.000
142ATP2A3ATPase, Ca++ transporting, ubiquitousCartilage+2.810.000
143EGR1early growth response 1Cartilage-2.790.000
144SORL1sortilin-related receptor, L(DLR class) A repeats containingCartilage+2.790.000
145CD2CD2 moleculeCartilage+2.760.000
146CECR1cat eye syndrome chromosome region, candidate 1Cartilage+2.760.000
147SORBS1sorbin and SH3 domain containing 1Cartilage-2.760.000
148APLNRapelin receptorCartilage+2.760.000
149SLAMF8SLAM family member 8Cartilage+2.760.000
150FADS1fatty acid desaturase 1Cartilage-2.750.006
151MAST1microtubule associated serine/threonine kinase 1Cartilage+2.750.000
152ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Cartilage+2.750.000
153GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)Cartilage+2.750.002
154CR1complement component (3b/4b) receptor 1 (Knops blood group)Cartilage+2.740.002
155LAMA3laminin, alpha 3Cartilage-2.730.002
156HLA-DMBmajor histocompatibility complex, class II, DM betaCartilage+2.730.000
157KLF9Kruppel-like factor 9Cartilage-2.730.000
158GPR65G protein-coupled receptor 65Cartilage+2.720.001
159IL27RAinterleukin 27 receptor, alphaCartilage+2.710.002
160FOSL1FOS-like antigen 1Cartilage-2.710.026
161FAPfibroblast activation protein, alphaCartilage+2.700.002
162SEPT6septin 6Cartilage+2.680.000
163BMP2KBMP2 inducible kinaseCartilage+2.680.001
164MS4A1membrane-spanning 4-domains, subfamily A, member 1Cartilage+2.670.005
165BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Cartilage+2.670.000
166SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Cartilage-2.660.003
167LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3Cartilage+2.660.000
168DUOX2dual oxidase 2Cartilage-2.660.003
169MTSS1metastasis suppressor 1Cartilage-2.660.000
170CXCL11chemokine (C-X-C motif) ligand 11Cartilage+2.660.011
171NR4A1nuclear receptor subfamily 4, group A, member 1Cartilage-2.650.002
172LDLRlow density lipoprotein receptorCartilage-2.650.005
173SDC3syndecan 3Cartilage+2.640.000
174PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Cartilage-2.640.005
175MT1Mmetallothionein 1MCartilage-2.630.000
176RTP4receptor (chemosensory) transporter protein 4Cartilage+2.630.000
177ZEB1zinc finger E-box binding homeobox 1Cartilage-2.620.001
178SLC12A8solute carrier family 12, member 8Cartilage+2.620.000
179CEP55centrosomal protein 55kDaCartilage+2.620.000
180PPAP2Bphosphatidic acid phosphatase type 2BCartilage-2.620.000
181BTN3A3butyrophilin, subfamily 3, member A3Cartilage+2.620.000
182TLR8toll-like receptor 8Cartilage+2.620.010
183CXCL6chemokine (C-X-C motif) ligand 6Cartilage+2.610.001
184RHOHras homolog family member HCartilage+2.600.002
185AIM2absent in melanoma 2Cartilage+2.600.000
186FLRT2fibronectin leucine rich transmembrane protein 2Cartilage+2.590.000
187CXCL5chemokine (C-X-C motif) ligand 5Cartilage+2.590.010
188HAS1hyaluronan synthase 1Cartilage-2.570.004
189SYKspleen tyrosine kinaseCartilage+2.560.000
190CD3DCD3d molecule, delta (CD3-TCR complex)Cartilage+2.560.000
191AOAHacyloxyacyl hydrolase (neutrophil)Cartilage+2.560.003
192ABCF2ATP-binding cassette, sub-family F (GCN20), member 2Cartilage-2.560.000
193CXCL9chemokine (C-X-C motif) ligand 9Cartilage+2.550.002
194HN1hematological and neurological expressed 1Cartilage+2.550.001
195BMP5bone morphogenetic protein 5Cartilage-2.540.020
196ACADLacyl-CoA dehydrogenase, long chainCartilage-2.540.001
197MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Cartilage+2.530.014
198LRMPlymphoid-restricted membrane proteinCartilage+2.520.001
199HBEGFheparin-binding EGF-like growth factorCartilage-2.520.004
200JUNDjun D proto-oncogeneCartilage-2.520.002
201C10orf10chromosome 10 open reading frame 10Cartilage-2.520.000
202SH2D1ASH2 domain containing 1ACartilage+2.520.004
203TNFSF11tumor necrosis factor (ligand) superfamily, member 11Cartilage+2.520.013
204PPP1R16Bprotein phosphatase 1, regulatory subunit 16BCartilage+2.510.000
205GPX3glutathione peroxidase 3 (plasma)Cartilage-2.510.000
206MYCv-myc avian myelocytomatosis viral oncogene homologCartilage-2.500.000
207SOCS3suppressor of cytokine signaling 3Cartilage-2.500.001
208DAZLdeleted in azoospermia-likeCartilage+2.500.000
209APOBEC3Fapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3FCartilage+2.500.000
210CD37CD37 moleculeCartilage+2.490.006
211DUSP1dual specificity phosphatase 1Cartilage-2.490.007
212IRS2insulin receptor substrate 2Cartilage-2.490.000
213CD58CD58 moleculeCartilage+2.490.001
214PITX1paired-like homeodomain 1Cartilage-2.480.012
215EPHB2EPH receptor B2Cartilage+2.470.000
216NPY1Rneuropeptide Y receptor Y1Cartilage-2.470.017
217KLRD1killer cell lectin-like receptor subfamily D, member 1Cartilage+2.470.000
218APOLD1apolipoprotein L domain containing 1Cartilage-2.470.000
219CNN1calponin 1, basic, smooth muscleCartilage-2.460.003
220ARCactivity-regulated cytoskeleton-associated proteinCartilage-2.450.018
221FIGFc-fos induced growth factor (vascular endothelial growth factor D)Cartilage-2.440.003
222CST7cystatin F (leukocystatin)Cartilage+2.440.000
223P2RY13purinergic receptor P2Y, G-protein coupled, 13Cartilage+2.430.022
224AOX1aldehyde oxidase 1Cartilage-2.430.025
225IKZF1IKAROS family zinc finger 1 (Ikaros)Cartilage+2.430.002
226AASSaminoadipate-semialdehyde synthaseCartilage-2.430.000
227PLNphospholambanCartilage-2.420.014
228TCEAL2transcription elongation factor A (SII)-like 2Cartilage-2.420.000
229KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Cartilage+2.420.011
230TGFBR3transforming growth factor, beta receptor IIICartilage-2.420.000
231CRIP1cysteine-rich protein 1 (intestinal)Cartilage+2.410.000
232BTN3A1butyrophilin, subfamily 3, member A1Cartilage+2.410.004
233TLR7toll-like receptor 7Cartilage+2.410.001
234IGLV4-60immunoglobulin lambda variable 4-60Cartilage+2.400.011
235LPLlipoprotein lipaseCartilage-2.400.008
236CDK5cyclin-dependent kinase 5Cartilage+2.400.001
237TMOD1tropomodulin 1Cartilage-2.390.015
238ICAM3intercellular adhesion molecule 3Cartilage+2.380.000
239CD27CD27 moleculeCartilage+2.370.000
240ST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1Cartilage+2.370.009
241AGTR1angiotensin II receptor, type 1Cartilage-2.370.000
242IL21Rinterleukin 21 receptorCartilage+2.370.000
243IFRD1interferon-related developmental regulator 1Cartilage-2.370.001
244ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Cartilage-2.370.000
245SCDstearoyl-CoA desaturase (delta-9-desaturase)Cartilage-2.370.027
246FKBP11FK506 binding protein 11, 19 kDaCartilage+2.360.000
247CALML4calmodulin-like 4Cartilage+2.360.000
248EDNRBendothelin receptor type BCartilage-2.350.000
249FYBFYN binding proteinCartilage+2.350.001
250CD247CD247 moleculeCartilage+2.350.000
251SLC2A6solute carrier family 2 (facilitated glucose transporter), member 6Cartilage+2.350.010
252TSKUtsukushi, small leucine rich proteoglycanCartilage-2.350.000
253TBX3T-box 3Cartilage-2.350.013
254IL7Rinterleukin 7 receptorCartilage+2.340.000
255CXCL10chemokine (C-X-C motif) ligand 10Cartilage+2.340.000
256HLA-DRAmajor histocompatibility complex, class II, DR alphaCartilage+2.330.000
257CA2carbonic anhydrase IICartilage+2.330.005
258C1orf21chromosome 1 open reading frame 21Cartilage-2.330.004
259TRDT cell receptor delta locusCartilage+2.320.002
260MSX2msh homeobox 2Cartilage+2.310.003
261KLRB1killer cell lectin-like receptor subfamily B, member 1Cartilage+2.310.001
262ITGB7integrin, beta 7Cartilage+2.310.002
263RUNX1-IT1RUNX1 intronic transcript 1 (non-protein coding)Cartilage+2.310.000
264COL1A2collagen, type I, alpha 2Cartilage+2.310.000
265ALOX5arachidonate 5-lipoxygenaseCartilage+2.300.000
266SLC6A3solute carrier family 6 (neurotransmitter transporter), member 3Cartilage-2.300.022
267ELL2elongation factor, RNA polymerase II, 2Cartilage-2.300.016
268IGLV6-57immunoglobulin lambda variable 6-57Cartilage+2.300.001
269SOD2superoxide dismutase 2, mitochondrialCartilage-2.290.000
270RTN1reticulon 1Cartilage+2.280.006
271NREPneuronal regeneration related proteinCartilage+2.280.000
272QPCTglutaminyl-peptide cyclotransferaseCartilage+2.280.021
273TPD52tumor protein D52Cartilage+2.280.000
274SELPLGselectin P ligandCartilage+2.270.004
275CD6CD6 moleculeCartilage+2.260.002
276SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Cartilage-2.250.002
277OLFM1olfactomedin 1Cartilage-2.250.002
278JUNBjun B proto-oncogeneCartilage-2.250.000
279PAX5paired box 5Cartilage+2.230.009
280AKR1C1aldo-keto reductase family 1, member C1Cartilage-2.230.007
281FOSFBJ murine osteosarcoma viral oncogene homologCartilage-2.220.010
282PIGAphosphatidylinositol glycan anchor biosynthesis, class ACartilage-2.220.000
283CD72CD72 moleculeCartilage+2.220.005
284FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)Cartilage-2.220.006
285CDO1cysteine dioxygenase type 1Cartilage-2.220.003
286XCL1chemokine (C motif) ligand 1Cartilage+2.210.017
287BTN3A2butyrophilin, subfamily 3, member A2Cartilage+2.210.006
288FAIM3Fas apoptotic inhibitory molecule 3Cartilage+2.210.015
289EREGepiregulinCartilage-2.210.004
290TPPP3tubulin polymerization-promoting protein family member 3Cartilage+2.200.009
291SPRY2sprouty homolog 2 (Drosophila)Cartilage-2.200.000
292GRAMD3GRAM domain containing 3Cartilage-2.200.020
293HLA-DMAmajor histocompatibility complex, class II, DM alphaCartilage+2.200.000
294COL5A1collagen, type V, alpha 1Cartilage+2.190.001
295CYBBcytochrome b-245, beta polypeptideCartilage+2.190.000
296MRPL35mitochondrial ribosomal protein L35Cartilage+2.190.028
297JAK2Janus kinase 2Cartilage+2.190.009
298ZFP36ZFP36 ring finger proteinCartilage-2.190.000
299GBP1guanylate binding protein 1, interferon-inducibleCartilage+2.180.001
300TRIM33tripartite motif containing 33Cartilage+2.180.013
301LIPElipase, hormone-sensitiveCartilage-2.180.007
302FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Cartilage+2.180.001
303MEG3maternally expressed 3 (non-protein coding)Cartilage-2.170.017
304CX3CL1chemokine (C-X3-C motif) ligand 1Cartilage-2.170.002
305PNOCprepronociceptinCartilage+2.170.005
306SEMA3Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3ECartilage-2.160.042
307CRY2cryptochrome circadian clock 2Cartilage-2.160.010
308NOL3nucleolar protein 3 (apoptosis repressor with CARD domain)Cartilage-2.150.041
309SCN9Asodium channel, voltage-gated, type IX, alpha subunitCartilage+2.150.008
310DENND1BDENN/MADD domain containing 1BCartilage+2.150.005
311CSF1Rcolony stimulating factor 1 receptorCartilage+2.140.000
312TACC3transforming, acidic coiled-coil containing protein 3Cartilage+2.140.002
313CDK1cyclin-dependent kinase 1Cartilage+2.130.002
314ST14suppression of tumorigenicity 14 (colon carcinoma)Cartilage+2.130.011
315MKI67marker of proliferation Ki-67Cartilage+2.130.002
316BCL6B-cell CLL/lymphoma 6Cartilage-2.130.000
317BTN2A2butyrophilin, subfamily 2, member A2Cartilage+2.130.006
318CYTIPcytohesin 1 interacting proteinCartilage+2.130.001
319CLEC4AC-type lectin domain family 4, member ACartilage+2.120.007
320CRLF1cytokine receptor-like factor 1Cartilage-2.120.014
321CD79ACD79a molecule, immunoglobulin-associated alphaCartilage+2.120.000
322NUSAP1nucleolar and spindle associated protein 1Cartilage+2.120.001
323ACACBacetyl-CoA carboxylase betaCartilage-2.110.002
324FLJ10038uncharacterized protein FLJ10038Cartilage-2.100.023
325HLA-DPB1major histocompatibility complex, class II, DP beta 1Cartilage+2.100.000
326PRG2proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)Cartilage-2.100.012
327WNT11wingless-type MMTV integration site family, member 11Cartilage-2.100.009
328KCNK3potassium channel, subfamily K, member 3Cartilage-2.100.001
329CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)Cartilage+2.090.018
330IFI30interferon, gamma-inducible protein 30Cartilage+2.090.003
331BLNKB-cell linkerCartilage+2.080.000
332PDLIM7PDZ and LIM domain 7 (enigma)Cartilage+2.080.025
333PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2Cartilage-2.080.005
334TNFRSF25tumor necrosis factor receptor superfamily, member 25Cartilage+2.080.005
335CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Cartilage-2.080.000
336ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3Cartilage+2.080.006
337AREGamphiregulinCartilage-2.080.045
338ITGAXintegrin, alpha X (complement component 3 receptor 4 subunit)Cartilage+2.080.017
339ZC3H12Azinc finger CCCH-type containing 12ACartilage-2.080.022
340ARG2arginase 2Cartilage-2.070.012
341LTBP4latent transforming growth factor beta binding protein 4Cartilage-2.060.012
342TMEM100transmembrane protein 100Cartilage-2.060.041
343VEGFAvascular endothelial growth factor ACartilage-2.060.013
344KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1Cartilage-2.050.028
345LOC399491GPS, PLAT and transmembrane domain-containing proteinCartilage-2.050.011
346IER2immediate early response 2Cartilage-2.040.001
347SPTBN1spectrin, beta, non-erythrocytic 1Cartilage-2.030.048
348CDH19cadherin 19, type 2Cartilage-2.030.003
349MAPK8mitogen-activated protein kinase 8Cartilage-2.020.011
350SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1Cartilage-2.020.002
351CCNL1cyclin L1Cartilage-2.020.001
352GGT5gamma-glutamyltransferase 5Cartilage-2.020.022
353ITGA7integrin, alpha 7Cartilage-2.010.037
354GABARAPL1GABA(A) receptor-associated protein like 1Cartilage-2.000.000
355SLCO4A1solute carrier organic anion transporter family, member 4A1Cartilage-2.000.015
356SMAD3SMAD family member 3Cartilage-1.960.015
357ZFAND5zinc finger, AN1-type domain 5Cartilage-1.960.004
358TFtransferrinCartilage-1.960.032
359NLGN1neuroligin 1Cartilage-1.950.009
360PLIN2perilipin 2Cartilage-1.930.012
361GRB10growth factor receptor-bound protein 10Cartilage-1.910.030
362CXCL2chemokine (C-X-C motif) ligand 2Cartilage-1.910.046
363CPceruloplasmin (ferroxidase)Cartilage-1.900.033
364ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Cartilage-1.900.012
365SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Cartilage-1.900.044
366KLHL21kelch-like family member 21Cartilage-1.890.037
367EIF4A1eukaryotic translation initiation factor 4A1Cartilage-1.890.001
368DDIT4DNA-damage-inducible transcript 4Cartilage-1.890.021
369NEUROG3neurogenin 3Cartilage-1.890.034
370IL1R1interleukin 1 receptor, type ICartilage-1.880.038
371CLDN5claudin 5Cartilage-1.880.047
372ABLIM1actin binding LIM protein 1Cartilage-1.870.001
373SASH1SAM and SH3 domain containing 1Cartilage-1.870.003
374MAP1Bmicrotubule-associated protein 1BCartilage-1.860.014
375WASLWiskott-Aldrich syndrome-likeCartilage-1.860.031
376GPHNgephyrinCartilage-1.850.041
377WASF3WAS protein family, member 3Cartilage-1.850.000
378SOX9SRY (sex determining region Y)-box 9Cartilage-1.850.004
379GPC5glypican 5Cartilage-1.840.028
380PID1phosphotyrosine interaction domain containing 1Cartilage-1.840.015
381SDC4syndecan 4Cartilage-1.840.009
382SFRP1secreted frizzled-related protein 1Cartilage-1.830.000
383MAB21L2mab-21-like 2 (C. elegans)Cartilage-1.830.020
384ZNF395zinc finger protein 395Cartilage-1.830.002
385BAG3BCL2-associated athanogene 3Cartilage-1.820.003
386EGFRepidermal growth factor receptorCartilage-1.820.002
387MT1Xmetallothionein 1XCartilage-1.810.003
388YBX3Y box binding protein 3Cartilage-1.810.002
389PDE4Bphosphodiesterase 4B, cAMP-specificCartilage-1.810.024
390PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaCartilage-1.800.024
391PLS1plastin 1Cartilage-1.800.024
392AKAP1A kinase (PRKA) anchor protein 1Cartilage-1.780.002
393FSTL3follistatin-like 3 (secreted glycoprotein)Cartilage-1.780.020
394P2RY2purinergic receptor P2Y, G-protein coupled, 2Cartilage-1.770.023
395GSNgelsolinCartilage-1.770.041
396PNPLA2patatin-like phospholipase domain containing 2Cartilage-1.760.035
397SLC16A7solute carrier family 16 (monocarboxylate transporter), member 7Cartilage-1.750.013
398RND3Rho family GTPase 3Cartilage-1.750.000
399PER2period circadian clock 2Cartilage-1.740.049
400NAV2neuron navigator 2Cartilage-1.720.011

Expression patterns in normal tissues for genes affiliated with Rheumatoid Arthritis

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

About this section

Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IL10, CIITA, PTPN22
210.5HLA-DRB1, IL6, IL1A
3
Show member pathways
10.5HLA-DRB1, CIITA, IL6, IL1A
410.5HLA-DRB1, CIITA, IL10, IL6, IL1A
5
Show member pathways
10.5HLA-DRB1, CIITA, IL10, IL6, IL1A
610.5HLA-DRB1, IL10, IL6, IL1A
710.5IL1A, IL6, IL10
810.5IL1A, IL6, IL10
910.5IL1A, IL6, IL10
1010.5IL1A, IL6, IL10
11
Show member pathways
10.5HLA-DRB1, CIITA, CCL2, IL6, IL1A
1210.5IL6, IL10, CCL2
13
Show member pathways
10.5PTPN22, CCL2, IL10, IL6, IL1A
14
Show member pathways
Type III interferon signaling37
10.5STAT4, IL10, IL6
1510.5IL1A, IL6, CCL2
16
Show member pathways
thioredoxin pathway37
10.5SAA1, CCL2, IL6
17
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.5IL17A, IL10, IL6, IL1A
18
Show member pathways
10.5IL17A, IL17RA, IL6
19
Show member pathways
10.5IL6, IL17RA, IL17A
20
Show member pathways
IL27-mediated signaling events37
10.5IL6, IL10, IL17A, STAT4
21
Show member pathways
10.4IL1A, HLA-DRB1, CIITA, STAT4, IL17A, IL10
22
Show member pathways
10.4STAT4, CCL2, IL10, IL6, IL1A
23
Show member pathways
10.4STAT4, CCL2, IL10, IL6, IL1A
24
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
10.4STAT4, CCL2, IL17A, IL10, IL6
25
Show member pathways
10.4IL6, IL17RA, IL17A, STAT4
2610.4HLA-DRB1, CCL2, IL17A, IL6, IL1A, CTSK
27
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.4STAT4, CCL2, IL10, IL6, CTSK
28
Show member pathways
10.4CCL2, IL17A, IL17RA, IL10, IL6, IL1A

Compounds for genes affiliated with Rheumatoid Arthritis

About this section

Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1groalpha4410.9IL10, IL6, IL1A, CCL2, IL17A
2il-124410.9IL6, CCL2, STAT4, IL10
3polyinosinic-polycytidylic acid4410.9IL6, IL10, IL1A, CIITA
4polymyxin b4410.9IL1A, IL6, IL10, CCL2
5simvastatin44 50 60 29 25 1215.9CIITA, SAA1, IL1A, CCL2, IL10, IL6
6gm-csf44 2911.9IL1A, IL6, IL10, CCL2
7endotoxin4410.9IL1A, SAA1, IL6, IL10, CCL2, IL17A
8il 104410.9IL6, IL10, IL1A, CCL2
9rantes4410.9IL17A, CIITA, IL6, IL1A, IL10, IL17RA
10tenidap44 2911.9IL6, IL1A, SAA1
11nitric oxide44 25 1212.9CIITA, SERPINH1, CCL2, IL17A, IL10, IL6
12arginine4410.9PADI4, SLC22A4, SAA1, IL1A, PTPN22, HLA-DRB1
13ccl344 2911.9CCL2, IL10, IL6, IL1A
14cyclosporin a44 29 6012.9IL1A, IL6, IL10, IL17A, SERPINH1, CIITA
15allergens4410.9IL10, STAT4, HLA-DRB1, CIITA
16dexamethasone44 50 29 1213.9IL6, SAA1, STAT4, CCL2, IL17A, IL10
17glatiramer acetate44 1211.9IL10, CIITA, HLA-DRB1
18mcp 14410.9CCL2, IL6, IL10
19toxin-14410.9IL10, CCL2, CIITA
20pge24410.9IL1A, IL6, IL10, IL17A, CIITA, CCL2
21tyrosine4410.9HLA-DRB1, CIITA, SERPINH1, STAT4, IL17A, CD244
22mip 1alpha4410.9CCL2, IL10, IL6
23mdms4410.8CCL2, CIITA, IL10
24aprotinin44 1211.8CTSK, IL1A, IL6, IL10
25corticosterone44 60 2512.8IL1A, SLC22A4, CCL2, IL10
26imiquimod44 60 29 1213.8IL1A, IL6, IL10
27sb 20358044 6011.8IL6, IL17A, IL1A, CCL2, IL10
28vitamin d4410.8IL6, SLC11A1, IL1A, CCL2, IL10
29ly2940024410.8CD244, IL6, IL10, IL17A, CCL2
30lipoteichoic acid4410.8IL6, IL10, CCL2
31actinomycin d4410.8CCL2, IL17A, IL6, IL1A, CIITA
328-isoprostane4410.8CCL2, IL10, IL6
33vegf4410.8CCL2, SERPINH1, IL1A, IL6, IL10, IL17A
34lipid4410.8CCL2, IL17A, CIITA, IL6, SLC22A4, CD244
35etanercept44 50 1212.8IL17A, IL10, IL6
36curcumin4410.8IL1A, IL6, IL17A, CCL2
37muramyl tripeptide4410.7CCL2, IL1A
38thymidine44 2511.7CIITA, IL17A, IL10, IL6, IL1A
39iron sucrose4410.7CCL2, IL6
40aspartate4410.7SLC11A1, IL1A, IL10, CCL2, CTSK
41methotrexate50 44 1212.7IL17A, HLA-DRB1, IL10, IL6
42tarc4410.7IL1A, IL10, CCL2
43infliximab44 50 1212.6IL17A, IL10, IL6
44peptidoglycan44 2911.6IL10, IL6, CIITA
45ivig4410.6IL6, IL10, IL1A
46pentoxifylline44 1211.5IL1A, IL6, IL10
47fluvastatin44 50 29 1213.5IL6, CCL2, IL1A
48cycloheximide4410.5CIITA, IL1A, IL10, IL6, CCL2
49cdp5714410.4IL6, IL10
50ifn-alpha4410.2IL17A, IL10, IL6

GO Terms for genes affiliated with Rheumatoid Arthritis

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Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4CTSK, IL1A, IL6, IL17RA, CCL2, SAA1
2extracellular spaceGO:00561510.3CTSK, IL1A, IL6, IL10, IL17A, CCL2
3external side of plasma membraneGO:00989710.2HLA-DRB1, IL17A, IL6, CD244

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:04667710.8IL6, CCL2, CIITA
2cytokine-mediated signaling pathwayGO:01922110.8IL1A, HLA-DRB1, CIITA, STAT4, CCL2, IL17RA
3positive regulation of cytokine secretionGO:05071510.8SAA1, IL10, IL1A
4inflammatory responseGO:00695410.8CIITA, CCL2, IL17A, IL10, IL6, IL1A
5negative regulation of collagen biosynthetic processGO:03296610.8IL6, CIITA
6regulation of vascular endothelial growth factor productionGO:01057410.8IL6, CCL2
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.8CIITA, STAT4, IL17A, IL10, IL6, IL1A
8fibroblast activationGO:07253710.8IL17A, IL17RA
9humoral immune responseGO:00695910.8IL6, CCL2, BST1
10positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, CIITA
11positive regulation of interleukin-23 productionGO:03274710.8IL17A, IL17RA
12lymphocyte chemotaxisGO:04824710.8CCL2, SAA1
13positive regulation of cytokine production involved in inflammatory responseGO:190001710.7IL17RA, IL17A
14cellular response to lipopolysaccharideGO:07122210.7CCL2, IL10, NFKBIL1
15response to glucocorticoidGO:05138410.7IL6, IL10, CCL2
16immune responseGO:00695510.7IL1A, IL17A, CIITA, HLA-DRB1
17agingGO:00756810.7CIITA, CCL2, IL6
18macrophage chemotaxisGO:04824610.7CCL2, SAA1
19defense response to protozoanGO:04283210.6SLC11A1, IL6
20monocyte chemotaxisGO:00254810.6CCL2, IL6
21response to bacteriumGO:00961710.6SLC11A1, CCL2
22response to interferon-gammaGO:03434110.5CIITA, SLC11A1
23defense response to Gram-negative bacteriumGO:05082910.5SLC11A1, IL6
24JAK-STAT cascadeGO:00725910.5CCL2, STAT4
25response to amino acidGO:04320010.4IL6, CCL2
26negative regulation of interferon-gamma productionGO:03268910.2IL10, HLA-DRB1

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.5IL1A, IL6, IL10, IL17A

Products for genes affiliated with Rheumatoid Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Rheumatoid Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet