RA
MCID: RHM011
MIFTS: 91

Rheumatoid Arthritis (RA) malady

Bone diseases category

Summaries for Rheumatoid Arthritis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rheumatoid Arthritis, also known as rheumatoid arthritis, susceptibility to, is related to arthritis and juvenile rheumatoid arthritis. An important gene associated with Rheumatoid Arthritis is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Leishmaniasis and Immune System. The drugs meclofenamate sodium and salsalate and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

CDC:3 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Genetics Home Reference:21 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

Wikipedia:63 Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory... more...

Description from OMIM:46 180300

Aliases & Classifications for Rheumatoid Arthritis

About this section
Sources:
8Disease Ontology, 9diseasecard, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

rheumatoid arthritis 8 21 46 10 44 33 30 60
rheumatoid arthritis, susceptibility to 9 22
arthritis 8 60
polyarthritis, rheumatic 8
arthritis, rheumatoid 21
atrophic arthritis 8
ra 21


External Ids:

Disease Ontology8 DOID:7148
OMIM46 180300
ICD9CM27 714.0
MeSH34 D001172
ICD1025 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rheumatoid Arthritis family:

Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1073)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.8IL1A, IL17A, IL6
2juvenile rheumatoid arthritis32.0HLA-DRB1, IL1A, IL6, SLC11A1
3osteoarthritis31.7CCL2, SAA1, CTSK, IL1A, IL17A, IL6
4systemic lupus erythematosus31.6STAT4
5synovitis31.5IL6, IL17A, IL1A
6psoriatic arthritis31.3PTPN22, IL1A, HLA-DRB1
7amyloidosis31.3SAA1
8vasculitis31.2IL17A, CCL2
9pneumonia31.2IL6, IL17A, IL10, CCL2
10tuberculosis31.1SLC11A1, IL17A, IL10, CIITA, HLA-DRB1
11interstitial lung disease31.1CCL2
12atherosclerosis31.1CCL2, SAA1, CTSK, STAT4, CIITA, IL10
13periodontitis31.1CCL2, IL10, IL1A, IL17A, IL6
14glomerulonephritis31.1SERPINH1, CCL2
15polymyalgia rheumatica31.1HLA-DRB1
16leukemia31.0HLA-DRB1, BST1, IL1A, IL17A, IL6, PADI4
17connective tissue disease31.0CCL2, HLA-DRB1, IL10, IL6, PTPN22
18uveitis30.9IL17A, IL1A, IL10, CCL2
19psoriasis30.9CCL2, HLA-DRB1, CIITA, IL10, IL1A, IL17A
20thyroiditis30.8PTPN22, CIITA, HLA-DRB1
21dermatitis30.8IL17A, IL1A
22periodontal disease30.8IL1A, IL17A, IL6
23crohn's disease30.8SLC22A4
24diabetes mellitus30.7PTPN22, IL6, HLA-DRB1, CCL2
25dermatomyositis30.7IL17A, IL1A
26gingivitis30.7IL17A, IL1A
27hepatitis c30.7HLA-DRB1, CIITA, IL10
28bronchiolitis obliterans30.7IL17A
29asthma30.7CCL2, HLA-DRB1, STAT4, CIITA, IL10, IL17A
30hepatitis b30.7IL17A, IL10, HLA-DRB1
31myositis30.7IL1A, CIITA
32multiple sclerosis30.6CCL2, HLA-DRB1, STAT4, CIITA, IL10, IL17A
33ulcerative colitis30.6HLA-DRB1, STAT4, IL10, IL1A, IL17A, IL6
34lymphopenia30.6CIITA, IL10, IL6, PTPN22
35prostate cancer30.5IL6, CTSK
36leishmaniasis30.5IL10, SLC11A1
37sjogren's syndrome30.5CIITA
38hypertension30.5CCL2
39influenza30.5CIITA
40familial mediterranean fever30.5SAA1
41sarcoidosis30.5SLC11A1, IL1A, HLA-DRB1, CCL2
42pulmonary fibrosis30.5CCL2, CTSK, SERPINH1
43myeloma30.5IL6, CIITA, CTSK
44myocardial infarction30.5CIITA, SAA1
45wegener's granulomatosis30.5CIITA
46toxic shock syndrome30.5CIITA
47acute leukemia30.5IL17A
48systemic scleroderma30.4CCL2, HLA-DRB1, CIITA, IL1A, IL17A, PTPN22
49obesity30.4IL6, IL17A, CTSK, CCL2
50keratitis30.4IL17A

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Clinical Features for Rheumatoid Arthritis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

180300

Clinical synopsis from OMIM:

180300

Drugs & Therapeutics for Rheumatoid Arthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Rheumatoid Arthritis

Search NIH Clinical Center for Rheumatoid Arthritis

Highlights from CenterWatch's Drugs in Clinical Trials Database for Rheumatoid Arthritis:

idCompanyCompoundMechanismPhase
1TiGenix NVCx611Expanded allogeneic adult stem cell product derived from human adipose tissueIIa
2Lexicon PharmaceuticalsLX2931An orally available small molecule inhibitor of S1P lyaseII
3Janssen BiotechsirukumabA human monoclonal IgG1 kappa antibodyIII
4AstraZenecafostamatinibA mast cell macrophage and B-cell activation-blocking solid-dosage prodrug of an oral Syk kinase inhibitorIII
5Eli LillybaricitinibAn oral JAK1/JAK2 inhibitorIII

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Genetic Tests for Rheumatoid Arthritis

About this section
Sources:
22GTR
See all sources

Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis22

Anatomical Context for Rheumatoid Arthritis

About this section
Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Rheumatoid Arthritis:

32
T cells, Bone, Monocytes, Endothelial, B cells, Lung, Skin, Eye, Testes, Bone marrow, Myeloid, Heart, Liver, Thyroid, Pituitary, Kidney, Whole blood, Breast, Lymph node, Spleen, Salivary gland, Nk cells, Brain, Tongue, Colon, Small intestine, Thymus, Smooth muscle, Spinal cord, Placenta, Prostate, Tonsil, Retina

FMA organs/tissues related to Rheumatoid Arthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.4SLC11A1, IL17A, IL17RA, IL1A, IL10, CD244
2MP:000539713.0SLC11A1, IL6, IL1A, PTPN22, IL10, CIITA
3MP:000537612.7PTPN22, IL6, IL17RA, IL10, CIITA, STAT4
4MP:000538412.2IL17A, STAT4, IL6, IL17RA, IL10, CIITA
5MP:000200611.5CCL2, IL10, IL17RA, SLC11A1, IL6
6MP:000538811.0SERPINH1, IL6, CTSK

Publications for Rheumatoid Arthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7202)
idTitleAuthorsYear
1
Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis. (24378614)
2014
2
Parenteral methotrexate for the treatment of rheumatoid arthritis. (24219041)
2013
3
Intra-articular CD1c-expressing myeloid dendritic cells from rheumatoid arthritis patients express a unique set of T cell-attracting chemokines and spontaneously induce Th1, Th17 and Th2 cell activity. (24286358)
2013
4
Tongue diagnosis of traditional Chinese medicine for rheumatoid arthritis. (24311851)
2013
5
Acute retropharyngeal calcific tendinitis in an unusual location: a case report in a patient with rheumatoid arthritis and atlantoaxial subluxation. (21852912)
2011
6
Lumbar radiculopathy caused by foraminal stenosis in rheumatoid arthritis. (21091389)
2011
7
No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population. (20690084)
2010
8
Circadian pattern and the effect of standardized physical exercise on procollagen IIA N-peptide (PIIANP) in rheumatoid arthritis at different stages and in healthy individuals. (19814628)
2010
9
Targeting IL-17 and Th17 cells in rheumatoid arthritis. (20510238)
2010
10
IL-21 regulates Th17 cells in rheumatoid arthritis. (20079789)
2010
11
E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy. (19487269)
2009
12
Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis. (19446472)
2009
13
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. (19503088)
2009
14
Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis? (18171484)
2008
15
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. (18055470)
2008
16
Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis. (17965559)
2007
17
Infliximab for rheumatoid arthritis. (20477071)
2006
18
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
19
Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis. (16142883)
2005
20
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
21
Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. (13130465)
2003
22
Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress. (12890858)
2003
23
Role of interleukin 18 in rheumatoid arthritis. (14532149)
2003
24
Activated leucocytes express and secrete macrophage inflammatory protein-1alpha upon interaction with synovial fibroblasts of rheumatoid arthritis via a beta2-integrin/ICAM-1 mechanism. (12832710)
2003
25
Macrophage activation syndrome following initiation of etanercept in a child with systemic onset juvenile rheumatoid arthritis. (12563702)
2003
26
CCR3, CCR5, interleukin 4, and interferon-gamma expression on synovial and peripheral T cells and monocytes in patients with rheumatoid arthritis. (12966592)
2003
27
Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. (12695153)
2003
28
Patient compliance in rheumatoid arthritis, polymyalgia rheumatica, and gout. (12508389)
2003
29
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis. (12595628)
2003
30
Chronic eosinophilic pneumonia associated with an initiation of rheumatoid arthritis. (14505220)
2003
31
Regional analysis of p53 mutations in rheumatoid arthritis synovium. (12119414)
2002
32
The angiogenic pathway "vascular endothelial growth factor/flk-1(KDR)-receptor" in rheumatoid arthritis and osteoarthritis. (11329148)
2001
33
Rise in serum C reactive protein after hip and knee arthroplasties in patients with rheumatoid arthritis. (11171691)
2001
34
Preference for nonsteroidal antiinflammatory drugs over acetaminophen by rheumatic disease patients: a survey of 1,799 patients with osteoarthritis, rheumatoid arthritis, and fibromyalgia. (10693878)
2000
35
Expression of the precursor of secretoneurin, secretogranin II, in the synovium of patients with rheumatoid arthritis and osteoarthritis. (11036828)
2000
36
Gene therapy approaches for treating rheumatoid arthritis. (11039782)
2000
37
Bucillamine-induced nephropathy in a child with juvenile rheumatoid arthritis and Kartagener's syndrome. (10881595)
2000
38
Clinico-immunological profile of juvenile rheumatoid arthritis at Chandigarh. (10728033)
1999
39
Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset. (9771209)
1998
40
Clinical relapse of rheumatoid arthritis (escape phenomenon) during low-dose methotrexate therapy]. (9564772)
1998
41
High levels of blood IgA in patients with rheumatoid arthritis]. (9304070)
1997
42
Immunoregulatory role of interleukin 10 in rheumatoid arthritis. (8163935)
1994
43
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
44
Towards peptide immunotherapy in rheumatoid arthritis: competitor-modulator concept. (1380244)
1992
45
Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis. (1282009)
1992
46
Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. (1930331)
1991
47
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. (2209707)
1990
48
Classical rheumatoid arthritis associated with nondeforming relapsing polychondritis. (3496456)
1987
49
Pleurisy in rheumatoid arthritis. (6857177)
1983
50
Pityriasis rosea-like rashes complicating drug therapy for rheumatoid arthritis. (6871589)
1983

Genetic Variations for Rheumatoid Arthritis

About this section

Expression for genes affiliated with Rheumatoid Arthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rheumatoid Arthritis

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

About this section
Sources:
29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
See all sources

Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9IL10, IL1A, IL17A, IL6, STAT4, HLA-DRB1
2
Hide members
11.7IL1A, CIITA, IL6, HLA-DRB1, CTSK, SAA1
311.5IL1A, IL10, CIITA, HLA-DRB1, IL6
4
Hide members
11.5IL1A, IL10, CIITA, IL6, HLA-DRB1
5
Hide members
11.5IL6, CIITA, CCL2, IL1A, HLA-DRB1
6
Hide members
11.5STAT4, IL6, IL10, CCL2, IL1A
7
Hide members
11.5IL1A, IL6, IL10, STAT4, CCL2
8
Hide members
11.5IL10, IL6, CTSK, CCL2, STAT4
9
Development PDGF signaling via STATs and NF-kB
Hide members
11.5IL10, IL17A, STAT4, CCL2, IL6
10
Hide members
11.3IL1A, IL6, HLA-DRB1, CIITA
11
Hide members
11.3IL6, IL17A, STAT4, IL10
12
Hide members
11.3IL17A, IL6, IL10, IL1A
1311.1HLA-DRB1, IL1A, IL6
1411.1IL6, IL1A, IL10
1511.1IL10, IL6, IL1A
1611.1IL1A, IL6, IL10
17
Hide members
11.1STAT4, IL17RA, IL6
1811.1SAA1, IL6, CCL2
19
Cytokine production by Th17 cells in CF (Mouse model)
11.1IL17RA, IL17A, IL6
20
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
11.1IL6, IL17A, IL17RA
21
Hide members
11.1IL1A, IL17A, IL17RA
22
Hide members
10.7PTPN22
2310.7HLA-DRB1
2410.7CTSK

Compounds for genes affiliated with Rheumatoid Arthritis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.7CD244, SERPINH1, PTPN22, CTSK, IL6, IL17A
2nitric oxide44 11 2414.5CCL2, CIITA, IL1A, IL17A, IL6, SLC11A1
3arginine4412.3PTPN22, PADI4, CCL2, SAA1, SLC22A4, IL1A
4simvastatin44 49 59 28 11 2417.1CCL2, SAA1, CIITA, IL10, IL1A, IL6
5lipid4412.1IL17A, CIITA, SAA1, SLC22A4, IL6, CCL2
6vegf4412.0IL10, CCL2, IL17A, IL6, SERPINH1, IL1A
7groalpha4411.9IL17A, IL6, IL1A, IL10, CCL2
8rantes4411.9IL17A, IL17RA, IL1A, CIITA, IL6
9sb 20358044 5912.9IL17A, IL1A, IL10, IL6, CCL2
10vitamin d4411.9IL6, IL1A, IL10, CCL2, SLC11A1
11ly2940024411.9CD244, IL17A, CCL2, IL10, IL6
12actinomycin d4411.8CCL2, CIITA, IL17A, IL6, IL1A
13il-124411.7IL6, STAT4, CCL2, IL10
14polymyxin b4411.7CCL2, IL10, IL1A, IL6
15polyinosinic-polycytidylic acid4411.7IL6, IL1A, CIITA, IL10
16il 104411.7IL6, IL1A, IL10, CCL2
17ccl344 2812.7IL6, CCL2, IL10, IL1A
18allergens4411.7IL10, CIITA, STAT4, HLA-DRB1
19corticosterone44 59 2413.7SLC22A4, IL1A, IL10, CCL2
20thymidine44 2412.6CIITA, IL1A, IL6, IL17A, IL10
21curcumin4411.6CCL2, IL1A, IL6, IL17A
22dexamethasone44 49 28 1114.5IL6, CIITA, SAA1
23mcp 14411.5IL10, IL6, CCL2
24toxin-14411.5CIITA, IL10, CCL2
25mip 1alpha4411.5IL6, CCL2, IL10
26methotrexate44 49 1113.5IL6, IL10, HLA-DRB1, IL17A
27cyclosporin a44 28 5913.5IL17A, CIITA, SERPINH1
28glatiramer acetate44 1112.5CIITA, HLA-DRB1, IL10
29mdms4411.5CIITA, IL10, CCL2
30imiquimod44 28 59 1114.5IL1A, IL6, IL10
31lipoteichoic acid4411.4IL10, IL6, CCL2
328-isoprostane4411.4CCL2, IL6, IL10
33etanercept44 49 1113.4IL10, IL6, IL17A
34infliximab44 49 1113.4IL10, IL17A, IL6
35tarc4411.3IL10, CCL2, IL1A
36endotoxin4411.3CIITA, SAA1
37peptidoglycan44 2812.3CIITA, IL6, IL10
38ivig4411.3IL10, IL6, IL1A
39tenidap44 2812.3SAA1, IL1A
40muramyl tripeptide4411.2IL1A, CCL2
41aspartate4411.2CCL2, CTSK, IL1A, SLC11A1
42iron sucrose4411.2IL6, CCL2
43fluvastatin44 49 28 1114.2IL1A, IL6, CCL2
44cdp5714411.2IL6, IL10
45gm-csf44 2812.1IL10
46ifn-alpha4411.1IL10, IL17A, IL6
4715-deoxy-delta-12,14-prostaglandin j24411.1IL10, IL6, CCL2
48aprotinin44 1112.1CTSK
49trinitrobenzenesulfonic acid4411.0IL10, IL17A
50neopterin4410.8IL10, IL6, IL1A

GO Terms for genes affiliated with Rheumatoid Arthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6SERPINH1, CCL2, CTSK, IL10, IL1A, IL17A
2external side of plasma membraneGO:00989711.3IL6, IL17A, CD244, HLA-DRB1

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594412.2STAT4, CIITA, IL10, IL1A, IL17A, IL6
2cytokine-mediated signaling pathwayGO:01922112.0IL6, IL1A, CIITA, STAT4, HLA-DRB1, CCL2
3inflammatory responseGO:00695412.0CCL2, IL10, IL1A, IL17A, IL6, SLC11A1
4positive regulation of cytokine secretionGO:05071511.4SAA1, IL10, IL1A
5response to antibioticGO:04667711.3IL6, CIITA, CCL2
6humoral immune responseGO:00695911.3IL6, BST1, CCL2
7fibroblast activationGO:07253711.1IL17RA, IL17A
8negative regulation of collagen biosynthetic processGO:03296611.1CIITA, IL6
9regulation of vascular endothelial growth factor productionGO:01057411.1CCL2, IL6
10positive regulation of interleukin-23 productionGO:03274711.0IL17A, IL17RA
11positive regulation of cytokine production involved in inflammatory responseGO:190001711.0IL17RA, IL17A
12response to glucocorticoid stimulusGO:05138411.0CCL2, IL10, IL6
13lymphocyte chemotaxisGO:04824711.0CCL2, SAA1
14positive regulation of MHC class II biosynthetic processGO:04534810.9CIITA, IL10
15macrophage chemotaxisGO:04824610.9SAA1, CCL2
16cellular response to lipopolysaccharideGO:07122210.8IL10, NFKBIL1, CCL2

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.3IL6, IL17A, IL1A, IL10

Products for genes affiliated with Rheumatoid Arthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatoid Arthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet