MCID: RHM011
MIFTS: 91

Rheumatoid Arthritis

Categories: Rare diseases, Bone diseases, Respiratory diseases, Genetic diseases

Aliases & Classifications for Rheumatoid Arthritis

MalaCards integrated aliases for Rheumatoid Arthritis:

Name: Rheumatoid Arthritis 53 37 12 72 24 71 36 28 51 40 3 14 69 59
Ra 53 24 71 3
Arthritis, Rheumatoid 24 41
Rheumatoid Arthritis, Susceptibility to 53
Arthritis or Polyarthritis, Rheumatic 12
Atrophic Arthritis 12

Characteristics:

OMIM:

53
Inheritance:
unproved inheritance


Classifications:



External Ids:

OMIM 53 180300
Disease Ontology 12 DOID:7148
ICD9CM 34 714.0
MeSH 41 D001172
NCIt 46 C27206 C2884
MedGen 39 C0003873
KEGG 36 H00630
UMLS 69 C0003873

Summaries for Rheumatoid Arthritis

MedlinePlus : 40 Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers. More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime. Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Rheumatoid Arthritis, also known as ra, is related to juvenile rheumatoid arthritis and arthritis, and has symptoms including abnormality of the immune system, abnormality of the nervous system and vasculitis. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Rheumatoid arthritis and Innate Immune System. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, bone and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

OMIM : 53 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. (180300)

UniProtKB/Swiss-Prot : 71 Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Genetics Home Reference : 24 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

Disease Ontology : 12 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

PubMed Health : 59
About rheumatoid arthritis: There are many different rheumatic diseases, but rheumatoid arthritis is probably the most common. In rheumatoid arthritis, people usually have several permanently inflamed joints. This causes the joints to gradually become deformed and stiff. Over time the muscles also weaken.Someone with advanced rheumatoid arthritis may have difficulties with simple tasks such as washing themselves, eating with a knife and fork, or buttoning up a shirt. Other symptoms such as pain and fatigue can be very troublesome too. This disease can also affect other parts of the body, like the blood vessels or certain organs.Rheumatoid arthritis usually gradually worsens over the course of many years. Various treatments can relieve the pain and slow the progression of the disease. Early diagnosis and treatment can help to prevent damage to the joints.

Wikipedia : 72 Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically... more...

Related Diseases for Rheumatoid Arthritis

Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 945)
# Related Disease Score Top Affiliating Genes
1 juvenile rheumatoid arthritis 35.7 HLA-DRB1 IL1B IL6 TNF TNFRSF1B
2 arthritis 34.5 CCL2 CSF1 FCRL3 HLA-DRB1 IL10 IL17A
3 rheumatoid lung disease 34.0 IL17A MMP3 TNF TNFRSF1B
4 adult-onset still's disease 33.9 CSF1 IL1B IL6 TNF
5 palindromic rheumatism 33.8 HLA-DRB1 IL1B PADI4 PTPN22 TNF TNFRSF1B
6 interstitial lung disease 33.7 CCL2 IL10 IL1A IL1B IL6 TNF
7 spondyloarthropathy 1 33.6 IL17A MMP3 TNF TNFRSF1B TNFSF11
8 psoriasis 33.6 CCL2 IL10 IL17A IL1A IL1B IL6
9 mixed connective tissue disease 33.5 HLA-DRB1 IL10 IL6 TNF
10 bronchiolitis obliterans 33.5 IL10 IL17A IL6 TNF
11 systemic onset juvenile idiopathic arthritis 33.4 IL1B TNF
12 systemic lupus erythematosus 32.6 CCL2 CSF1 FCRL3 HLA-DRB1 IL10 IL17A
13 osteoarthritis 32.6 IL1B IL6 MMP3 TNF TNFSF11
14 synovitis 32.5 IL1B IL6 MMP3 TNF TNFSF11
15 psoriatic arthritis 32.3 HLA-DRB1 IL17A IL1A IL1B MMP3 PTPN22
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 32.2 IL10 IL17A PTPN22
17 spondylitis 32.2 IL17A IL6 TNF TNFRSF1B
18 periodontitis 32.2 CCL2 IL10 IL17A IL1A IL1B IL6
19 spondyloarthropathy 32.1 IL10 IL17A IL6 MMP3 TNF TNFSF11
20 pneumonia 32.1 CCL2 IL10 IL1B IL6 TNF
21 lung disease 32.1 CCL2 IL10 IL1B TNF
22 temporal arteritis 32.1 CCL2 HLA-DRB1 IL6 PTPN22
23 mycobacterium tuberculosis 1 32.0 IL10 IL17A TNF TNFRSF1B
24 osteoporosis 32.0 CSF1 IL1A IL1B IL6 TNF TNFSF11
25 connective tissue disease 31.9 HLA-DRB1 IL10 IL1A IL6 TNF
26 uveitis 31.9 CCL2 IL10 IL17A IL1A TNF
27 autoimmune disease 31.9 CIITA FCRL3 HLA-DRB1 IL10 IL17A IL1B
28 rheumatic disease 31.8 HLA-DRB1 IL10 IL1B TNF
29 periodontal disease 31.8 IL17A IL1A IL1B IL6 MMP3 TNF
30 reactive arthritis 31.8 IL10 IL17A IL6 TNF
31 crohn's disease 31.7 IL10 IL1B IL6 SLC22A4 TNF TNFRSF1B
32 colitis 31.7 IL10 IL17A IL1B IL6 TNF
33 multiple sclerosis 31.7 CCL2 CIITA FCRL3 HLA-DRB1 IL10 IL17A
34 gingivitis 31.7 IL1A IL1B IL6 TNF
35 pericarditis 31.6 IL1B IL6 TNF
36 asthma 31.6 CCL2 HLA-DRB1 IL10 IL17A IL1A IL1B
37 diabetes mellitus 31.6 HLA-DRB1 IL1B IL6 PTPN22 TNF
38 inflammatory bowel disease 31.6 CCL2 HLA-DRB1 IL10 IL17A IL1A IL1B
39 bone inflammation disease 31.5 CCL2 HLA-DRB1 IL10 IL17A IL1A IL1B
40 ulcerative colitis 31.5 IL10 IL1B IL6 TNF
41 leishmaniasis 31.5 HLA-DRB1 IL10 IL1A IL1B TNF
42 keratoconjunctivitis sicca 31.5 IL1A IL1B IL6 TNF
43 ischemic heart disease 31.5 CCL2 IL6 TNF
44 brucellosis 31.4 IL10 IL6 TNF
45 peritonitis 31.4 CCL2 IL10 IL1B IL6 TNF
46 myocardial infarction 31.4 CCL2 CIITA IL10 IL1B IL6 MMP3
47 meningitis 31.4 CCL2 IL10 IL1B IL6 TNF
48 bronchiolitis 31.4 IL10 IL6 TNF
49 toxic shock syndrome 31.4 CIITA IL10 IL1B IL6 TNF
50 pneumoconiosis 31.3 CCL2 IL1A IL1B IL6 TNF

Comorbidity relations with Rheumatoid Arthritis via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Bronchiectasis Bronchitis
Chronic Rheumatic Pericarditis Conn's Syndrome
Decubitus Ulcer Deficiency Anemia
Esophagitis Felty Syndrome
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Idiopathic Interstitial Pneumonia Immune Deficiency Disease
Iron Deficiency Anemia Mononeuropathy of the Median Nerve, Mild
Neutropenia Olecranon Bursitis
Oral Candidiasis Osteoarthritis
Osteoporosis Perforated Corneal Ulcer
Postinflammatory Pulmonary Fibrosis Premature Ovarian Failure 7
Protein-Energy Malnutrition Rheumatoid Lung Disease
Scleritis Sjogren Syndrome
Spondyloarthropathy 1 Systemic Lupus Erythematosus
Temporal Arteritis

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to Rheumatoid Arthritis

Symptoms & Phenotypes for Rheumatoid Arthritis

Symptoms via clinical synopsis from OMIM:

53
Joints:
rheumatoid arthritis

Limbs:
rheumatoid nodules

Vascular:
rheumatoid vasculitis

Neuro:
rheumatoid vasculitic mononeuritis

Immunology:
hla-drb1 association

Pulm:
rheumatoid lung disease

Heme:
felty syndrome


Clinical features from OMIM:

180300

Human phenotypes related to Rheumatoid Arthritis:

31 (show all 6)
# Description HPO Frequency HPO Source Accession
1 abnormality of the immune system 31 HP:0002715
2 abnormality of the nervous system 31 HP:0000707
3 vasculitis 31 HP:0002633
4 abnormality of blood and blood-forming tissues 31 HP:0001871
5 abnormality of the respiratory system 31 HP:0002086
6 rheumatoid arthritis 31 HP:0001370

UMLS symptoms related to Rheumatoid Arthritis:


sciatica, muscle cramp, back pain

MGI Mouse Phenotypes related to Rheumatoid Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 CD244 IL1A CIITA IL1B CSF1 IL6
2 homeostasis/metabolism MP:0005376 10.2 IL1A CIITA IL1B CSF1 IL6 IL10
3 immune system MP:0005387 10.19 CCL2 CD244 IL1A CIITA IL1B CSF1
4 endocrine/exocrine gland MP:0005379 10.1 CIITA CSF1 IL6 IL10 IL17A TNFSF11
5 craniofacial MP:0005382 9.98 IL17A IL1B CSF1 IL10 TNFSF11 TNF
6 neoplasm MP:0002006 9.7 IL1A IL1B IL6 IL10 TNFSF11 TNF
7 respiratory system MP:0005388 9.56 CSF1 IL6 IL10 IL17A TNFSF11 PTPN22
8 skeleton MP:0005390 9.36 CIITA IL1B CSF1 IL6 IL10 MMP3

Drugs & Therapeutics for Rheumatoid Arthritis

PubMedHealth treatment related to Rheumatoid Arthritis: 59

Rheumatoid arthritis is treated with both medication and non-drug approaches, such as physiotherapy. There are also various support aids available for making everyday tasks easier. Which of these treatments are suitable options will depend on, for example, how severe the inflammation and the symptoms are, how advanced the disease is, the expected progression of the disease – and how well previous treatments have worked.Medication canreduce inflammation and help keep the disease from getting worse,relieve symptoms like pain and swelling, andhelp people move their joints more easily again, or at least maintain joint flexibility for as long as possible.There is currently no cure for rheumatoid arthritis.Physiotherapy and sports can help improve or maintain flexibility, strength and joint function. Many types of sports are suitable for people who have rheumatoid arthritis, including cycling, brisk walking, dancing, aerobics, strength training, swimming and water aerobics. Occupational therapy can be used to maintain your flexibility and hand strength, and to learn how to cope with rheumatoid arthritis in everyday life.Psychological treatments are also sometimes used to help relieve pain and minimize the impact it has on everyday life. They are also intended to help relieve disease-related anxiety and depression that some people develop.Support aids are designed to help compensate for physical limitations and help with daily activities. These include orthopedic shoe inserts, grabbing aids and specially designed cutlery.

Drugs for Rheumatoid Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 571)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
2
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
4
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
5
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
7
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
11
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5359476 5353980
12
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
13
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
14
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
15
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
16
Menthol Approved Phase 4,Phase 3,Early Phase 1 2216-51-5 16666
17
Dimethyl fumarate Approved, Investigational Phase 4,Phase 2 624-49-7 5271565 637568
18
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
19
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
20
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 9579578 4594
21
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 156391 1302
22
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
23
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
24
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
25
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
26
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
27
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
28
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 46835353 6436030 5284616
29
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
30
chloroquine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 54-05-7 2719
31
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
32
Ethanol Approved Phase 4,Phase 2 64-17-5 702
33
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
35
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
36
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
37
Norepinephrine Approved Phase 4 51-41-2 439260
38
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
39
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
40 Racepinephrine Approved Phase 4 329-65-7
41
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
42
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
43
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
44
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
45
Promethazine Approved, Investigational Phase 4 60-87-7 4927
46
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Phase 2 378-44-9 9782
47
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 477600-75-2
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
49
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
50
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088

Interventional clinical trials:

(show top 50) (show all 2374)

# Name Status NCT ID Phase Drugs
1 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
4 Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT01548001 Phase 4 Iguratimod;Methotrexate
5 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
6 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
7 Targeted Ultrasound in Rheumatoid Arthritis Unknown status NCT02056184 Phase 4 Adalimumab
8 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
9 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
10 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
11 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
12 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
13 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
14 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
15 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
16 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
17 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
18 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
19 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
20 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
21 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
22 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
23 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
24 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
25 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
26 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
27 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
28 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
29 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
30 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
31 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
32 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
33 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
34 Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA) Completed NCT01382160 Phase 4
35 Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate Therapy Completed NCT00244556 Phase 4 Methotrexate plus ENBREL or ENBREL alone
36 A Study of Iguratimod in Patients With Active Rheumatoid Arthritis Completed NCT01554917 Phase 4 Iguratimod
37 Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis Completed NCT01225991 Phase 4 Milnacipran
38 Treatment of Rheumatoid Arthritis With Roxithromycin Completed NCT00439062 Phase 4 Roxithromycin
39 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
40 Relaxation Response Training for the Treatment of Rheumatoid Arthritis Completed NCT00056667 Phase 4
41 Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis Completed NCT01404429 Phase 4 Methotrexate
42 The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study. Completed NCT01270087 Phase 4 Adalimumab
43 Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects Completed NCT00252668 Phase 4 Etanercept;Methotrexate
44 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
45 A Non-Interventional Study Evaluating Rheumatoid Arthritis Participants Treated With Tocilizumab (RoActemra/Actemra) Completed NCT01671059 Phase 4
46 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
47 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
48 Prospective Study on Intensive Early Rheumatoid Arthritis Treatment Completed NCT00480272 Phase 4 adalimumab, plus prednisone;adalimumab plus placebo
49 Efficacy of HUMIRA in Subjects With Active Rheumatoid Arthritis Completed NCT00234897 Phase 4 adalimumab
50 Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial Completed NCT01400516 Phase 4 Teriparatide;calcium citrate;Vitamin D;TNF antagonist

Search NIH Clinical Center for Rheumatoid Arthritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: arthritis, rheumatoid

Genetic Tests for Rheumatoid Arthritis

Genetic tests related to Rheumatoid Arthritis:

# Genetic test Affiliating Genes
1 Rheumatoid Arthritis 28 CD244 CIITA HLA-DRB1 IL10 NFKBIL1 PADI4 PTPN22 SLC22A4

Anatomical Context for Rheumatoid Arthritis

MalaCards organs/tissues related to Rheumatoid Arthritis:

38
Bone, T Cells, Lung, Endothelial, B Cells, Monocytes, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Rheumatoid Arthritis:

18
Joint
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease

Publications for Rheumatoid Arthritis

Articles related to Rheumatoid Arthritis:

(show top 50) (show all 8543)
# Title Authors Year
1
Anti-citrullinated alpha enolase antibodies, interstitial lung disease and bone erosion in rheumatoid arthritis. ( 29452423 )
2018
2
Predictors for orthopaedic surgery in patients with rheumatoid arthritis: results from a retrospective cohort study of 1010 patients diagnosed from 1972 to 2009 and followed up until 2015. ( 29447542 )
2018
3
Association of polymorphic variants in IL1B gene with secretion of IL-1I^ protein and inflammatory markers in north Indian rheumatoid arthritis patients. ( 29054755 )
2018
4
Early hearing loss detection in rheumatoid arthritis and primary SjAPgren syndrome using extended high frequency audiometry. ( 29273832 )
2018
5
Physiotherapists' management of challenging situations in guiding people with rheumatoid arthritis to health-enhancing physical activity. ( 29447492 )
2018
6
Risk-factor analysis of adjacent segment disease requiring surgery after short lumbar fusion: the influence of rheumatoid arthritis. ( 29452286 )
2018
7
Predictors of revision, prosthetic joint infection and mortality following total hip or total knee arthroplasty in patients with rheumatoid arthritis: a nationwide cohort study using Danish healthcare registers. ( 29097373 )
2018
8
LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis. ( 28721682 )
2018
9
The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial. ( 28963724 )
2018
10
The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population. ( 29158166 )
2018
11
Repository corticotropin injection in patients with rheumatoid arthritis resistant to biologic therapies. ( 29445306 )
2018
12
Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis. ( 29439591 )
2018
13
Patient-reported Outcomes, Resource Use, and Social Participation of Patients with Rheumatoid Arthritis Treated with Biologics in Alberta: Experience of Indigenous and Non-indigenous Patients. ( 29449496 )
2018
14
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. ( 29449195 )
2018
15
Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease. ( 29413504 )
2018
16
Isolated Bicipito-radial Bursitis in a Patient With Rheumatoid Arthritis. ( 29280830 )
2018
17
Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis. ( 29442475 )
2018
18
Rheumatologists' Views and Experiences in Managing Rheumatoid Arthritis in Elderly Patients: A Qualitative Study. ( 29449497 )
2018
19
A new assessment tool for ulnar drift in patients with rheumatoid arthritis using pathophysiological parameters of the metacarpophalangeal joint. ( 29448870 )
2018
20
The relationship between depression and biologic treatment response in rheumatoid arthritis: An analysis of the British Society for Rheumatology Biologics Register. ( 29447376 )
2018
21
Use of biological disease modifying antirheumatic drugs in rheumatoid arthritis in Austria from 2008 to 2011 : AA retrospective analysis of 72% of the population. ( 29445863 )
2018
22
Early Psoriatic Arthritis Versus Early Seronegative Rheumatoid Arthritis: Role of Dermoscopy Combined with Ultrasonography for Differential Diagnosis. ( 29449498 )
2018
23
Therapeutic strategy for Rheumatoid Arthritis Patients who have achieved Remission. ( 29452300 )
2018
24
Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients. ( 29422324 )
2018
25
Radiological fibrosis score is strongly associated with worse survival in rheumatoid arthritis-related interstitial lung disease. ( 29446698 )
2018
26
Multiple extra-articular synovial cysts accompanied by rheumatoid arthritis in the bilateral elbow joints: A case report. ( 29443754 )
2018
27
Cerebral Toxoplasmosis Diagnosed by Nested-Polymerase Chain Reaction in a Patient with Rheumatoid Arthritis. ( 29321415 )
2018
28
Estimation of Posturographic Trajectory Using k-Nearest Neighbors Classifier in Patients with Rheumatoid Arthritis and Osteoarthritis. ( 29445994 )
2018
29
Rituximab therapy in rheumatoid arthritis and primary biliary cholangitis. ( 29338925 )
2018
30
Duration of treatment with bisphosphonates at the time of osteonecrosis of the jaw onset in patients with rheumatoid arthritis. Review. ( 29325766 )
2018
31
High Adherence Observed to System-Level Performance Measures for Rheumatoid Arthritis in a National Early Arthritis Cohort Over 8 Years. ( 29450976 )
2018
32
Clinical Correlates, Outcomes, and Predictors of Inflammatory Ocular Disease Associated with Rheumatoid Arthritis in the Biologic Era. ( 29449499 )
2018
33
Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. ( 29422289 )
2018
34
Safety, and Humoral and Cell-mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis. ( 29419465 )
2018
35
TNFR1 and TNFR2 differentially mediate TNF-I+-induced inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes. ( 28150360 )
2017
36
Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity. ( 28990250 )
2017
37
EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. ( 27697765 )
2017
38
Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. ( 27860244 )
2017
39
Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States. ( 29141716 )
2017
40
Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise. ( 28461643 )
2017
41
Reply to: Need for improvements in reported cost-effectiveness ofA adalimumab in rheumatoid arthritis. ( 28084541 )
2017
42
Psychometric properties of the painDETECT questionnaire in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: Rasch analysis and test-retest reliability. ( 28532452 )
2017
43
Nephrocalcinosis in a patient with rheumatoid arthritis and secondary SjAPgren's syndrome. ( 28359765 )
2017
44
A study on the physical fitness of children with juvenile rheumatoid arthritis. ( 28356614 )
2017
45
Translation, cultural adaptation and validation of the English "Short form SF 12v2" into Bengali in rheumatoid arthritis patients. ( 28532468 )
2017
46
Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis. ( 27476070 )
2017
47
A genetic variant within SLC30A6 has a protective role in the severity of rheumatoid arthritis. ( 27758124 )
2017
48
Comparison of cardiovascular risk algorithms in patients with vs without rheumatoid arthritis and the role of C-reactive protein in predicting cardiovascular outcomes in rheumatoid arthritis. ( 28087832 )
2017
49
Constitutive Activation of Integrin I+9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. ( 29038247 )
2017
50
YKL-40 and cytokines - a New Diagnostic Constellation in Rheumatoid Arthritis? ( 28384116 )
2017