Rheumatoid Arthritis malady

Genetic diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Rheumatoid Arthritis

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Aliases & Descriptions for Rheumatoid Arthritis:

Name: Rheumatoid Arthritis 46 30 8 21 10 44 32 2 61
Arthritis, Rheumatoid 21 22
Arthritis 8 61
Ra 21 2
Rheumatoid Arthritis, Susceptibility to 9
Rheumatoid Arthritis, Progression of 46
Polyarthritis, Rheumatic 8
Atrophic Arthritis 8


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OMIM46 180300
Disease Ontology8 DOID:7148
ICD9CM27 714.0
MeSH33 D001172
ICD1025 M05.3, M06.8

Summaries for Rheumatoid Arthritis

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MedlinePlus:32 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Rheumatoid Arthritis, also known as arthritis, rheumatoid, is related to arthritis and juvenile rheumatoid arthritis, and has symptoms including abnormality of the nervous system, rheumatoid arthritis and abnormality of blood and blood-forming tissues. An important gene associated with Rheumatoid Arthritis is IL10 (interleukin 10), and among its related pathways are Allograft rejection and Tuberculosis. The drugs aspirin and auranofin and the compounds endotoxin and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

CDC:2 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Genetics Home Reference:21 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

OMIM:46 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex... (180300) more...

Wikipedia:64 Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints. It... more...

Related Diseases for Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1210)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis33.9IL1A, IL6, IL17A
2juvenile rheumatoid arthritis33.1HLA-DRB1, IL6, IL1A, SLC11A1
3osteoarthritis32.7PADI4, SAA1, CCL2, IL17A, IL6, IL1A
4systemic lupus erythematosus32.6STAT4
5synovitis32.5IL17A, IL6, IL1A
6psoriatic arthritis32.3HLA-DRB1, PTPN22, IL1A
7pneumonia32.2CCL2, IL17A, IL10, IL6
8periodontitis32.2CCL2, IL17A, IL10, IL6, IL1A
9atherosclerosis32.2CIITA, SAA1, STAT4, CCL2, IL17A, IL10
10tuberculosis32.2HLA-DRB1, CIITA, IL17A, IL10, SLC11A1
11uveitis32.0CCL2, IL17A, IL10, IL1A
12connective tissue disease32.0HLA-DRB1, PTPN22, CCL2, IL10, IL6
13psoriasis32.0HLA-DRB1, PTPN22, CIITA, CCL2, IL17A, IL10
14leukemia31.9IL1A, IL6, IL17A, PADI4, HLA-DRB1, BST1
15thyroiditis31.9HLA-DRB1, PTPN22, CIITA
16colitis31.8IL17A, IL17RA, IL10, IL6
17periodontal disease31.8IL17A, IL6, IL1A
18crohn's disease31.7SLC22A4
19asthma31.7HLA-DRB1, CIITA, STAT4, CCL2, IL17A, IL10
20lymphopenia31.7PTPN22, CIITA, IL10, IL6
21ulcerative colitis31.6HLA-DRB1, STAT4, IL17A, IL10, IL6, IL1A
22hepatitis b31.6IL10, IL17A, HLA-DRB1
23hepatitis c31.6IL10, CIITA, HLA-DRB1
24pulmonary fibrosis31.5SERPINH1, CCL2, CTSK
25inflammatory bowel disease31.5PTPN22, CIITA, STAT4, CCL2, IL17A, IL10
26gingivitis31.4IL17A, IL1A
27visceral leishmaniasis31.4SLC11A1, IL10
28pulmonary tuberculosis31.4HLA-DRB1, IL10, SLC11A1
29obesity31.4CCL2, IL17A, IL6, CTSK
30atopic dermatitis31.4IL1A, IL10, IL17A, CCL2
31graves' disease31.3IL1A, CIITA, FCRL3, PTPN22, HLA-DRB1
32pemphigus vulgaris31.3IL1A, CIITA, HLA-DRB1
33alopecia areata31.2IL1A, CIITA
34lupus nephritis31.2CIITA, CCL2, IL10
35vascular disease31.2IL1A, IL6, IL10
36leprosy31.2SLC11A1, HLA-DRB1
37allergic asthma31.1CCL2, IL17A, IL10
38endometriosis31.0IL1A, IL6, IL17A, CCL2
39ocular cicatricial pemphigoid31.0CIITA
40systemic scleroderma31.0HLA-DRB1, PTPN22, CIITA, SERPINH1, CCL2, IL17A
41skin disease31.0IL1A, IL10, IL17A, CIITA
42coronary artery disease31.0IL6, IL17A, CCL2, SAA1
43encephalitis31.0CIITA, CCL2, IL17A
44brucellosis30.9SAA1, SLC11A1
45multiple sclerosis, disease progression, modifier of30.8SLC11A1, IL6, IL10, IL17A, CCL2, STAT4
46kawasaki disease30.7CCL2, CIITA
47congenital heart disease30.6IL6, IL10, CCL2
48sarcoidosis 130.5SLC11A1, IL1A, CCL2, HLA-DRB1
49bacterial vaginosis30.4SERPINH1, IL1A
50chorioamnionitis30.4IL6, SERPINH1

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:

Diseases related to rheumatoid arthritis

Symptoms for Rheumatoid Arthritis

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Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:


HPO human phenotypes related to Rheumatoid Arthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707
2 rheumatoid arthritis HP:0001370
3 abnormality of blood and blood-forming tissues HP:0001871
4 abnormality of the respiratory system HP:0002086
5 vasculitis HP:0002633
6 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Rheumatoid Arthritis

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Drug clinical trials:

Search ClinicalTrials for Rheumatoid Arthritis

Search NIH Clinical Center for Rheumatoid Arthritis

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Genetic Tests for Rheumatoid Arthritis

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Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis22

Anatomical Context for Rheumatoid Arthritis

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MalaCards organs/tissues related to Rheumatoid Arthritis:

T cells, Bone, Endothelial, Monocytes, B cells, Neutrophil, Lung, Skin, Eye, Bone marrow, Testes, Thyroid, Brain, Heart, Myeloid, Smooth muscle, Liver, Pituitary, Kidney, Whole blood, Spleen, Colon, Breast, Lymph node, Adipocyte, Tongue, Salivary gland, Nk cells, Thymus, Small intestine, Retina, Spinal cord, Placenta, Prostate, Tonsil

FMA organs/tissues related to Rheumatoid Arthritis:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Arthritis:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7CD244, CIITA, PADI4, STAT4, CCL2, IL17A
2MP:000539710.7SLC11A1, PTPN22, CIITA, PADI4, CCL2, IL17A
3MP:000537610.7CIITA, PTPN22, SAA1, STAT4, SLC22A4, CTSK
4MP:000538110.6SERPINH1, SLC11A1, SLC22A4, IL6, IL10, IL17A
5MP:000538810.6SERPINH1, IL6, CTSK, IL10, IL17RA, IL17A
6MP:000200610.5CCL2, SLC11A1, IL1A, IL6, IL10, IL17RA
7MP:000539010.5CTSK, IL6, IL10, IL17A, CCL2, SERPINH1
8MP:001076810.4IL17A, SLC11A1, SLC22A4, IL6, IL10, CCL2
9MP:000537910.2CTSK, IL10, CIITA, PTPN22, STAT4, IL6

Publications for Rheumatoid Arthritis

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Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7316)
Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. (25727025)
Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort. (25399388)
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
Response to: 'Comorbidities in a Mexican mestizo cohort with established rheumatoid arthritis' by Vega-Morales et al. (24336333)
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. (24222719)
Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. (23861880)
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
Evaluation of disease activity indices in Korean patients with rheumatoid arthritis. (21305296)
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
CIITA is not associated with risk of developing rheumatoid arthritis. (21248776)
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
Novel TNF antagonists for the treatment of rheumatoid arthritis. (20001558)
Association between the FCGR3A V158F polymorphism and the clinical response to infliximab in rheumatoid arthritis and spondyloarthritis patients. (20560817)
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate. (20439295)
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. (19035425)
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. (17530710)
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. (15248210)
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
Enrichment of T cells carrying beta7 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. (9779846)
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. (7551660)
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. (7818564)
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
New directions for biological therapy in rheumatoid arthritis. (8199454)
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)

Variations for Rheumatoid Arthritis

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UniProtKB/Swiss-Prot genetic disease variations for Rheumatoid Arthritis:

id Symbol AA change Variation ID SNP ID

Clinvar genetic disease variations for Rheumatoid Arthritis:

id Gene Variation Type Significance SNP ID Assembly Location
1CD244CD244, rs3766379undetermined variantrisk factor
2SLC22A4SLC22A4, IVS1, T-Csingle nucleotide variantrisk factor
3NFKBIL1NFKBIL1, -62T-Asingle nucleotide variantrisk factor
4PTPN22NM_015967.5(PTPN22): c.1858C> T (p.Arg620Trp)single nucleotide variantrisk factorrs2476601GRCh37Chr 1, 114377568: 114377568
5CIITAMHC2TA, -168A-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Rheumatoid Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Rheumatoid Arthritis patients vs. healthy controls: 30 (show all 57)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Cartilage-7.130.000
2ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideCartilage-5.820.000
3FOSBFBJ murine osteosarcoma viral oncogene homolog BCartilage-5.350.000
4ANGPTL7angiopoietin-like 7Cartilage-5.080.000
5PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Cartilage-5.070.000
6FAM107Afamily with sequence similarity 107, member ACartilage-4.850.000
7APODapolipoprotein DCartilage-4.400.000
8FKBP5FK506 binding protein 5Cartilage-4.090.002
9PLIN1perilipin 1Cartilage-4.040.000
10NPAS2neuronal PAS domain protein 2Cartilage-4.010.000
11DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedCartilage-3.910.023
12MAOAmonoamine oxidase ACartilage-3.850.000
13ZBTB16zinc finger and BTB domain containing 16Cartilage-3.840.000
14ADCY2adenylate cyclase 2 (brain)Cartilage-3.830.000
15TOX3TOX high mobility group box family member 3Cartilage-3.780.005
16GDF15growth differentiation factor 15Cartilage-3.740.000
17LMOD1leiomodin 1 (smooth muscle)Cartilage-3.650.000
18TRHDEthyrotropin-releasing hormone degrading enzymeCartilage-3.610.000
20MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FCartilage-3.410.000
21ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideCartilage-3.400.000
22NR4A2nuclear receptor subfamily 4, group A, member 2Cartilage-3.380.000
23NFIL3nuclear factor, interleukin 3 regulatedCartilage-3.360.000
24JUNjun proto-oncogeneCartilage-3.340.001
25PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Cartilage-3.330.000
26TIMP4TIMP metallopeptidase inhibitor 4Cartilage-3.290.000
27PER1period circadian clock 1Cartilage-3.270.000
28ADIPOQadiponectin, C1Q and collagen domain containingCartilage-3.240.001
29FABP4fatty acid binding protein 4, adipocyteCartilage-3.220.000
30LAMA2laminin, alpha 2Cartilage-3.210.000
31TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)Cartilage-3.210.000
32ATF3activating transcription factor 3Cartilage-3.190.000
33EIF1AYeukaryotic translation initiation factor 1A, Y-linkedCartilage-3.170.023
34RRADRas-related associated with diabetesCartilage-3.150.000
35MYOCmyocilin, trabecular meshwork inducible glucocorticoid responseCartilage-3.140.000
36C7complement component 7Cartilage-3.130.000
37MYH11myosin, heavy chain 11, smooth muscleCartilage-3.130.001
38GADD45Agrowth arrest and DNA-damage-inducible, alphaCartilage-3.120.000
39TET2tet methylcytosine dioxygenase 2Blood+3.120.000
40LIFleukemia inhibitory factorCartilage-3.110.009
42GADD45Bgrowth arrest and DNA-damage-inducible, betaCartilage-3.100.000
43RPS4Y1ribosomal protein S4, Y-linked 1Cartilage-3.080.026
44GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Cartilage+3.080.000
45ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Cartilage+3.070.000
47UCP2uncoupling protein 2 (mitochondrial, proton carrier)Cartilage+3.060.000
48AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Cartilage-3.050.000
49KLF4Kruppel-like factor 4 (gut)Cartilage-3.050.000
50TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Cartilage-3.040.000
51EIF1eukaryotic translation initiation factor 1Cartilage-3.030.003
52AIF1allograft inflammatory factor 1Cartilage+3.030.000
53CORO1Acoronin, actin binding protein, 1ACartilage+3.020.000
54PDK4pyruvate dehydrogenase kinase, isozyme 4Cartilage-3.020.027
55RAMP2receptor (G protein-coupled) activity modifying protein 2Cartilage-3.020.004
56CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Cartilage+3.000.000
57CCDC102Bcoiled-coil domain containing 102BCartilage+3.000.000

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

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Pathways related to Rheumatoid Arthritis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
Show member pathways
10.5IL1A, IL6, IL10, HLA-DRB1, CIITA
210.5IL1A, IL6, CIITA, HLA-DRB1, IL10
Show member pathways
10.5HLA-DRB1, IL6, IL1A, IL10, IL17A, STAT4
410.5PTPN22, CIITA, IL10
Show member pathways
10.5IL6, IL10, CCL2, PTPN22, IL1A
610.5IL6, HLA-DRB1, IL10, IL1A
Show member pathways
Show member pathways
910.5IL1A, IL6, IL10
1010.5IL1A, IL10, IL6
1110.5IL1A, IL6, IL10
1210.5IL6, IL10, IL1A
1310.5CCL2, IL6, IL10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
10.5IL17A, IL6, IL10, IL1A
Show member pathways
10.5STAT4, CCL2, IL10, IL6, IL1A
Show member pathways
10.5IL6, CCL2, IL10, STAT4, IL1A
1710.5IL1A, IL6, HLA-DRB1
Show member pathways
Type III interferon signaling36
10.5IL6, STAT4, IL10
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
10.5CCL2, STAT4, IL17A, IL10, IL6
Show member pathways
IL27-mediated signaling events36
10.5IL6, IL10, STAT4, IL17A
Show member pathways
10.5CCL2, IL1A, IL10, IL17RA, IL17A, IL6
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
10.5CCL2, IL10, IL6, STAT4, CTSK
2310.5IL6, CTSK, HLA-DRB1, IL1A, IL17A, CCL2
2410.5CCL2, IL1A, IL6
Show member pathways
thioredoxin pathway36
10.5SAA1, CCL2, IL6
Show member pathways
10.5IL17A, IL17RA, IL6
Show member pathways
10.5IL6, IL17RA, IL17A
Show member pathways
10.5STAT4, IL17A, IL6, IL17RA

Compounds for genes affiliated with Rheumatoid Arthritis

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Compounds related to Rheumatoid Arthritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9IL1A, SAA1, IL6, IL10, CCL2, IL17A
2nitric oxide44 24 1112.9CIITA, SERPINH1, CCL2, IL17A, IL10, IL6
3rantes4410.9IL17A, CIITA, IL6, IL1A, IL10, IL17RA
4groalpha4410.9IL10, IL6, IL1A, CCL2, IL17A
5simvastatin44 50 60 28 24 1115.9CIITA, SAA1, IL1A, CCL2, IL10, IL6
6dexamethasone44 50 28 1113.9IL6, SAA1, STAT4, CCL2, IL17A, IL10
7il-124410.9IL6, CCL2, STAT4, IL10
8polyinosinic-polycytidylic acid4410.9IL6, IL10, IL1A, CIITA
9polymyxin b4410.9IL1A, IL6, IL10, CCL2
10gm-csf44 2811.9IL1A, IL6, IL10, CCL2
11arginine4410.9PADI4, SLC22A4, SAA1, IL1A, PTPN22, HLA-DRB1
12cyclosporin a44 28 6012.9IL1A, IL6, IL10, IL17A, SERPINH1, CIITA
13il 104410.9IL6, IL10, IL1A, CCL2
14tyrosine4410.9HLA-DRB1, CIITA, SERPINH1, STAT4, IL17A, CD244
15ccl344 2811.9CCL2, IL10, IL6, IL1A
16pge24410.9IL1A, IL6, IL10, IL17A, CIITA, CCL2
17allergens4410.9IL10, STAT4, HLA-DRB1, CIITA
18tenidap44 2811.9IL6, IL1A, SAA1
19mcp 14410.9CCL2, IL6, IL10
20glatiramer acetate44 1111.9IL10, CIITA, HLA-DRB1
21toxin-14410.9IL10, CCL2, CIITA
22mip 1alpha4410.9CCL2, IL10, IL6
23mdms4410.9CCL2, CIITA, IL10
24aprotinin44 1111.9CTSK, IL1A, IL6, IL10
25corticosterone44 60 2412.9IL1A, SLC22A4, CCL2, IL10
26sb 20358044 6011.9IL6, IL17A, IL1A, CCL2, IL10
27vitamin d4410.9IL6, SLC11A1, IL1A, CCL2, IL10
28imiquimod44 60 28 1113.8IL1A, IL6, IL10
29ly2940024410.8CD244, IL6, IL10, IL17A, CCL2
30actinomycin d4410.8CCL2, IL17A, IL6, IL1A, CIITA
31lipoteichoic acid4410.8IL6, IL10, CCL2
32vegf4410.8CCL2, SERPINH1, IL1A, IL6, IL10, IL17A
338-isoprostane4410.8CCL2, IL10, IL6
34lipid4410.8CCL2, IL17A, CIITA, IL6, SLC22A4, CD244
35etanercept44 50 1112.8IL17A, IL10, IL6
36curcumin4410.8IL1A, IL6, IL17A, CCL2
37thymidine44 2411.8CIITA, IL17A, IL10, IL6, IL1A
38muramyl tripeptide4410.8CCL2, IL1A
39aspartate4410.7SLC11A1, IL1A, IL10, CCL2, CTSK
40methotrexate50 44 1112.7IL17A, HLA-DRB1, IL10, IL6
41iron sucrose4410.7CCL2, IL6
42tarc4410.7IL1A, IL10, CCL2
43infliximab44 50 1112.7IL17A, IL10, IL6
44peptidoglycan44 2811.6IL10, IL6, CIITA
45ivig4410.6IL6, IL10, IL1A
46pentoxifylline44 1111.6IL1A, IL6, IL10
47cycloheximide4410.5CIITA, IL1A, IL10, IL6, CCL2
48fluvastatin44 50 28 1113.5IL6, CCL2, IL1A
49cdp5714410.4IL6, IL10
50ifn-alpha4410.2IL17A, IL10, IL6

GO Terms for genes affiliated with Rheumatoid Arthritis

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Cellular components related to Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:000557610.5CTSK, IL1A, IL6, IL17RA, CCL2, SAA1
2extracellular spaceGO:000561510.4CTSK, IL1A, IL6, IL10, IL17A, CCL2
3external side of plasma membraneGO:000989710.2HLA-DRB1, IL17A, IL6, CD244

Biological processes related to Rheumatoid Arthritis according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:000695410.9IL17A, CIITA, SLC11A1, IL1A, IL6, IL10
2cytokine-mediated signaling pathwayGO:001922110.9HLA-DRB1, STAT4, CCL2, IL17RA, IL6, IL1A
3positive regulation of transcription from RNA polymerase II promoterGO:004594410.9SLC11A1, IL6, STAT4, IL17A, IL10, IL1A
4positive regulation of cytokine secretionGO:005071510.8IL10, IL1A, SAA1
5response to antibioticGO:004667710.8CCL2, CIITA, IL6
6negative regulation of collagen biosynthetic processGO:003296610.8CIITA, IL6
7fibroblast activationGO:007253710.8IL17RA, IL17A
8regulation of vascular endothelial growth factor productionGO:001057410.8CCL2, IL6
9humoral immune responseGO:000695910.8BST1, IL6, CCL2
10positive regulation of MHC class II biosynthetic processGO:004534810.8IL10, CIITA
11positive regulation of interleukin-23 productionGO:003274710.8IL17A, IL17RA
12positive regulation of cytokine production involved in inflammatory responseGO:0190001710.8IL17RA, IL17A
13cellular response to lipopolysaccharideGO:007122210.8IL10, CCL2, NFKBIL1
14lymphocyte chemotaxisGO:004824710.8SAA1, CCL2
15response to glucocorticoidGO:005138410.7CCL2, IL10, IL6
16immune responseGO:000695510.7IL1A, IL17A, CIITA, HLA-DRB1
17agingGO:000756810.7CCL2, IL6, CIITA
18macrophage chemotaxisGO:004824610.7CCL2, SAA1
19defense response to protozoanGO:004283210.7SLC11A1, IL6
20monocyte chemotaxisGO:000254810.6IL6, CCL2
21response to bacteriumGO:000961710.6CCL2, SLC11A1
22response to interferon-gammaGO:003434110.6SLC11A1, CIITA
23defense response to Gram-negative bacteriumGO:005082910.5SLC11A1, IL6
24JAK-STAT cascadeGO:000725910.5CCL2, STAT4
25response to amino acidGO:004320010.4IL6, CCL2
26negative regulation of interferon-gamma productionGO:003268910.2HLA-DRB1, IL10

Molecular functions related to Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.5IL1A, IL6, IL10, IL17A

Sources for Rheumatoid Arthritis

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26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet