RA
MCID: RHM011
MIFTS: 93

Rheumatoid Arthritis (RA) malady

Bone diseases, Rare diseases, Respiratory diseases categories
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Summaries for Rheumatoid Arthritis

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8Disease Ontology, 34MedlinePlus, 4CDC, 21Genetics Home Reference, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rheumatoid Arthritis, also known as rheumatoid arthritis, susceptibility to, is related to arthritis and juvenile rheumatoid arthritis. An important gene associated with Rheumatoid Arthritis is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Hematopoietic cell lineage and Lymphocyte Signaling. The drugs meclofenamate sodium and salsalate and the compounds il-12 and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are digestive/alimentary and immune system.

Disease Ontology:8 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

CDC:4 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Genetics Home Reference:21 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

Wikipedia:65 Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory... more...

Description from OMIM:47 180300

Aliases & Classifications for Rheumatoid Arthritis

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Respiratory diseases


Aliases & Descriptions:

rheumatoid arthritis 8 21 47 10 45 34 31 62
rheumatoid arthritis, susceptibility to 9 22
arthritis 8 62
polyarthritis, rheumatic 8
arthritis, rheumatoid 21
atrophic arthritis 8
ra 21


External Ids:

Disease Ontology8 DOID:7148
MeSH35 D001172
OMIM47 180300
ICD9CM27 714.0
ICD1025 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

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17GeneCards, 18GeneDecks
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Diseases in the Rheumatoid Arthritis family:

Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1212)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis33.1IL17A, IL1A, IL6
2juvenile rheumatoid arthritis32.3IL1A, IL6, HLA-DRB1, SLC11A1
3osteoarthritis31.9CCL2, SAA1, IL1A, CTSK, IL6, IL17A
4systemic lupus erythematosus31.9STAT4
5synovitis31.7IL1A, IL17A, IL6
6psoriatic arthritis31.5IL1A, PTPN22, HLA-DRB1
7pneumonia31.4IL10, CCL2, IL17A, IL6
8periodontitis31.4IL6, IL10, IL17A, CCL2, IL1A
9tuberculosis31.4IL10, HLA-DRB1, IL17A, CIITA, SLC11A1
10atherosclerosis31.4IL17A, IL6, CTSK, IL1A, CCL2, CIITA
11uveitis31.2CCL2, IL17A, IL10, IL1A
12connective tissue disease31.2CCL2, PTPN22, HLA-DRB1, IL10, IL6
13leukemia31.2PADI4, HLA-DRB1, IL1A, BST1, IL17A, IL6
14psoriasis31.1IL6, IL10, CIITA, PTPN22, HLA-DRB1, IL1A
15thyroiditis31.1HLA-DRB1, PTPN22, CIITA
16periodontal disease31.1IL17A, IL1A, IL6
17crohn's disease31.0SLC22A4
18diabetes mellitus31.0HLA-DRB1, PTPN22, CCL2, IL6
19gingivitis30.9IL1A, IL17A
20ulcerative colitis30.9SLC11A1, IL1A, IL6, IL10, IL17A, STAT4
21asthma30.9SLC11A1, IL10, IL17A, HLA-DRB1, STAT4, CCL2
22hepatitis b30.9IL10, HLA-DRB1, IL17A
23hepatitis c30.9HLA-DRB1, CIITA, IL10
24multiple sclerosis30.9CCL2, IL17A, IL10, IL6, SLC11A1, STAT4
25lymphopenia30.8PTPN22, CIITA, IL6, IL10
26vascular disease30.7IL10, IL6, IL1A
27pulmonary fibrosis30.7SERPINH1, CCL2, CTSK
28sarcoidosis30.7IL1A, SLC11A1, HLA-DRB1, CCL2
29sepsis30.7CCL2, IL17A, IL10, IL6, CIITA, IL1A
30visceral leishmaniasis30.7SLC11A1, IL10
31obesity30.6CTSK, CCL2, IL17A, IL6
32atopic dermatitis30.6IL17A, IL10, CCL2, IL1A
33graves' disease30.6IL1A, FCRL3, PTPN22, HLA-DRB1, CIITA
34pulmonary tuberculosis30.6IL10, HLA-DRB1, SLC11A1
35alopecia areata30.5CIITA, IL1A
36septic shock30.5IL10, IL1A, CIITA, IL6
37lupus nephritis30.4IL10, CIITA, CCL2
38pemphigus vulgaris30.4IL1A, HLA-DRB1, CIITA
39leprosy30.4SLC11A1, HLA-DRB1
40inflammatory bowel disease30.4SLC22A4, IL6, IL10, IL17A, STAT4, SLC11A1
41endometriosis30.3IL17A, CCL2, IL1A, IL6
42ocular cicatricial pemphigoid30.2CIITA
43encephalomyelitis30.2CIITA, IL10, STAT4, CCL2, IL17A
44skin disease30.2IL17A, CIITA, IL10, IL1A
45idiopathic pulmonary fibrosis30.2CCL2, SERPINH1, IL1A
46coronary artery disease30.2IL17A, IL6, SAA1, CCL2
47encephalitis30.2CCL2, CIITA, IL17A
48systemic scleroderma30.2HLA-DRB1, PTPN22, SERPINH1, CCL2, IL17A, IL1A
49allergic asthma30.2IL17A, CCL2, IL10
50kawasaki disease30.2CIITA, CCL2

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Symptoms for Rheumatoid Arthritis

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47OMIM
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Symptoms by clinical synopsis from OMIM:

180300

Clinical features from OMIM:

180300

Drugs & Therapeutics for Rheumatoid Arthritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Rheumatoid Arthritis

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22GTR
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Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis22

Anatomical Context for Rheumatoid Arthritis

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31LifeMap Discovery™, 33MalaCards, 14FMA
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MalaCards organs/tissues related to Rheumatoid Arthritis:

33
T cells, Bone, Monocytes, Endothelial, B cells, Lung, Skin, Eye, Testes, Bone marrow, Myeloid, Heart, Liver, Thyroid, Pituitary, Kidney, Whole blood, Breast, Lymph node, Spleen, Nk cells, Brain, Salivary gland, Colon, Tongue, Thymus, Small intestine, Tonsil, Retina, Prostate, Placenta, Spinal cord, Smooth muscle

FMA organs/tissues related to Rheumatoid Arthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Rheumatoid Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.5SERPINH1, SLC11A1, SLC22A4, IL6, IL10, IL17A
2MP:000538710.5CD244, CIITA, PADI4, STAT4, CCL2, IL17A
3MP:000539710.5SLC11A1, PTPN22, CIITA, PADI4, CCL2, IL17A
4MP:000538810.5SERPINH1, IL6, CTSK, IL10, IL17RA, IL17A
5MP:000537610.4CIITA, PTPN22, SAA1, STAT4, SLC22A4, CTSK
6MP:000200610.4CCL2, SLC11A1, IL1A, IL6, IL10, IL17RA
7MP:000539010.4CTSK, IL6, IL10, IL17A, CCL2, SERPINH1
8MP:001076810.3IL17A, SLC11A1, SLC22A4, IL6, IL10, CCL2
9MP:000537910.1CTSK, IL10, CIITA, PTPN22, STAT4, IL6

Publications for Rheumatoid Arthritis

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52PubMed
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Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7101)
idTitleAuthorsYear
1
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
2
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
3
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
4
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
5
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
2013
6
Response to: 'Comorbidities in a Mexican mestizo cohort with established rheumatoid arthritis' by Vega-Morales et al. (24336333)
2013
7
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. (24222719)
2013
8
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
9
Evaluation of disease activity indices in Korean patients with rheumatoid arthritis. (21305296)
2012
10
The clinical significance of HRCT in evaluation of patients with rheumatoid arthritis-associated interstitial lung disease: a report from China. (21132550)
2012
11
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
12
CIITA is not associated with risk of developing rheumatoid arthritis. (21248776)
2011
13
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
14
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
15
Novel TNF antagonists for the treatment of rheumatoid arthritis. (20001558)
2010
16
Association between the FCGR3A V158F polymorphism and the clinical response to infliximab in rheumatoid arthritis and spondyloarthritis patients. (20560817)
2010
17
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate. (20439295)
2010
18
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
19
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
20
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
21
Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. (19035425)
2008
22
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
23
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
24
Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis. (17265480)
2007
25
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. (17530710)
2007
26
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
27
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
28
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
29
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
30
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
31
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. (15248210)
2004
32
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
33
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
34
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
35
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
36
Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanese population. (10857804)
2000
37
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
38
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
39
Enrichment of T cells carrying beta7 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. (9779846)
1998
40
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
41
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. (7551660)
1995
42
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. (7818564)
1995
43
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
48
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
49
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Rheumatoid Arthritis

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Expression for genes affiliated with Rheumatoid Arthritis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatoid Arthritis

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

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Sources:
50PathCards, 30KEGG, 5Cell Signaling Technology, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 54R&D Systems, 60Thomson Reuters
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Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL1A, IL6, HLA-DRB1
210.4PTPN22, CIITA, IL10
310.4IL1A, IL10, IL6
410.4IL1A, IL6, IL10
510.4IL1A, IL6, IL10
610.4IL6, IL10, IL1A
710.4CCL2, IL6, IL10
810.4IL6, HLA-DRB1, IL10, IL1A
9
Show member pathways
Type III interferon signaling38
10.4IL6, STAT4, IL10
1010.4CCL2, IL1A, IL6
11
Show member pathways
10.4HLA-DRB1, CIITA, IL6, IL1A
12
Show member pathways
thioredoxin pathway38
10.4SAA1, CCL2, IL6
13
Show member pathways
10.4IL6, IL17RA, IL17A
14
Show member pathways
10.4IL17A, IL17RA, IL6
15
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
10.4IL17A, IL6, IL10, IL1A
16
Show member pathways
10.4IL6, IL10, CCL2, PTPN22, IL1A
17
Show member pathways
10.4IL1A, IL6, IL10, HLA-DRB1, CIITA
1810.4IL1A, IL6, CIITA, HLA-DRB1, IL10
19
Show member pathways
IL27-mediated signaling events38
10.4IL6, IL10, STAT4, IL17A
20
Show member pathways
10.4IL1A, IL6, CCL2, CIITA, HLA-DRB1
21
Show member pathways
10.4STAT4, IL17A, IL6, IL17RA
22
Show member pathways
10.4STAT4, CCL2, IL10, IL6, IL1A
23
Show member pathways
10.4IL6, CCL2, IL10, STAT4, IL1A
24
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.4CCL2, STAT4, IL17A, IL10, IL6
25
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
10.4CCL2, IL10, IL6, STAT4, CTSK
2610.4IL6, CTSK, HLA-DRB1, IL1A, IL17A, CCL2
27
Show member pathways
10.4CCL2, IL1A, IL10, IL17RA, IL17A, IL6
28
Show member pathways
10.4HLA-DRB1, IL6, IL1A, IL10, IL17A, STAT4

Compounds for genes affiliated with Rheumatoid Arthritis

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45Novoseek, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1il-124510.9IL6, CCL2, STAT4, IL10
2polymyxin b4510.9IL1A, IL6, IL10, CCL2
3gm-csf45 2911.9IL1A, IL6, IL10, CCL2
4groalpha4510.9IL10, IL6, IL1A, CCL2, IL17A
5tenidap45 2911.9IL6, IL1A, SAA1
6polyinosinic-polycytidylic acid4510.9IL6, IL10, IL1A, CIITA
7il 104510.9IL6, IL10, IL1A, CCL2
8ccl345 2911.8CCL2, IL10, IL6, IL1A
9mcp 14510.8CCL2, IL6, IL10
10simvastatin45 51 61 29 24 1115.8CIITA, SAA1, IL1A, CCL2, IL10, IL6
11glatiramer acetate45 1111.8IL10, CIITA, HLA-DRB1
12allergens4510.8IL10, STAT4, HLA-DRB1, CIITA
13mip 1alpha4510.8CCL2, IL10, IL6
14toxin-14510.8IL10, CCL2, CIITA
15endotoxin4510.8IL1A, SAA1, IL6, IL10, CCL2, IL17A
16arginine4510.8PADI4, SLC22A4, SAA1, IL1A, PTPN22, HLA-DRB1
17cyclosporin a45 29 6112.8IL1A, IL6, IL10, IL17A, SERPINH1, CIITA
18rantes4510.8IL17A, CIITA, IL6, IL1A, IL10, IL17RA
19mdms4510.8CCL2, CIITA, IL10
20nitric oxide45 24 1112.8CIITA, SERPINH1, CCL2, IL17A, IL10, IL6
21pge24510.8IL1A, IL6, IL10, IL17A, CIITA, CCL2
22aprotinin45 1111.8CTSK, IL1A, IL6, IL10
23imiquimod45 61 29 1113.8IL1A, IL6, IL10
24corticosterone45 61 2412.8IL1A, SLC22A4, CCL2, IL10
25dexamethasone45 51 29 1113.8IL6, SAA1, STAT4, CCL2, IL17A, IL10
26sb 20358045 6111.8IL6, IL17A, IL1A, CCL2, IL10
27tyrosine4510.8HLA-DRB1, CIITA, SERPINH1, STAT4, IL17A, CD244
28lipoteichoic acid4510.8IL6, IL10, CCL2
29vitamin d4510.8IL6, SLC11A1, IL1A, CCL2, IL10
30ly2940024510.8CD244, IL6, IL10, IL17A, CCL2
318-isoprostane4510.8CCL2, IL10, IL6
32actinomycin d4510.7CCL2, IL17A, IL6, IL1A, CIITA
33etanercept45 51 1112.7IL17A, IL10, IL6
34vegf4510.7CCL2, SERPINH1, IL1A, IL6, IL10, IL17A
35muramyl tripeptide4510.7CCL2, IL1A
36curcumin4510.7IL1A, IL6, IL17A, CCL2
37lipid4510.7CCL2, IL17A, CIITA, IL6, SLC22A4, CD244
38iron sucrose4510.7CCL2, IL6
39thymidine45 2411.7CIITA, IL17A, IL10, IL6, IL1A
40methotrexate51 45 1112.7IL17A, HLA-DRB1, IL10, IL6
41aspartate4510.7SLC11A1, IL1A, IL10, CCL2, CTSK
42tarc4510.6IL1A, IL10, CCL2
43infliximab45 51 1112.6IL17A, IL10, IL6
44peptidoglycan45 2911.6IL10, IL6, CIITA
45ivig4510.6IL6, IL10, IL1A
46pentoxifylline45 1111.5IL1A, IL6, IL10
47fluvastatin45 51 29 1113.4IL6, CCL2, IL1A
48cycloheximide4510.4CIITA, IL1A, IL10, IL6, CCL2
49cdp5714510.4IL6, IL10
50ifn-alpha4510.1IL17A, IL10, IL6

GO Terms for genes affiliated with Rheumatoid Arthritis

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16Gene Ontology
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Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4SAA1, CCL2, IL17RA, IL6, IL1A, CTSK
2extracellular spaceGO:00561510.3IL6, IL17A, IL1A, CTSK, CCL2, SERPINH1
3external side of plasma membraneGO:00989710.1CD244, IL6, IL17A, HLA-DRB1

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:05071510.8SAA1, IL10, IL1A
2regulation of vascular endothelial growth factor productionGO:01057410.8IL6, CCL2
3response to antibioticGO:04667710.8IL6, CCL2, CIITA
4fibroblast activationGO:07253710.8IL17A, IL17RA
5negative regulation of collagen biosynthetic processGO:03296610.8IL6, CIITA
6humoral immune responseGO:00695910.8IL6, CCL2, BST1
7positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, CIITA
8positive regulation of interleukin-23 productionGO:03274710.7IL17A, IL17RA
9cytokine-mediated signaling pathwayGO:01922110.7IL1A, HLA-DRB1, CIITA, STAT4, CCL2, IL17RA
10inflammatory responseGO:00695410.7CIITA, CCL2, IL17A, IL10, IL6, IL1A
11positive regulation of transcription from RNA polymerase II promoterGO:04594410.7CIITA, STAT4, IL17A, IL10, IL6, IL1A
12lymphocyte chemotaxisGO:04824710.7CCL2, SAA1
13positive regulation of cytokine production involved in inflammatory responseGO:190001710.7IL17RA, IL17A
14cellular response to lipopolysaccharideGO:07122210.7CCL2, IL10, NFKBIL1
15response to glucocorticoidGO:05138410.7IL6, IL10, CCL2
16immune responseGO:00695510.7IL1A, IL17A, CIITA, HLA-DRB1
17agingGO:00756810.7CIITA, CCL2, IL6
18macrophage chemotaxisGO:04824610.6CCL2, SAA1
19defense response to protozoanGO:04283210.6SLC11A1, IL6
20monocyte chemotaxisGO:00254810.6CCL2, IL6
21response to bacteriumGO:00961710.6SLC11A1, CCL2
22response to interferon-gammaGO:03434110.5CIITA, SLC11A1
23defense response to Gram-negative bacteriumGO:05082910.5SLC11A1, IL6
24JAK-STAT cascadeGO:00725910.4CCL2, STAT4
25response to amino acidGO:04320010.4IL6, CCL2
26negative regulation of interferon-gamma productionGO:03268910.2IL10, HLA-DRB1

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.4IL1A, IL6, IL10, IL17A

Products for genes affiliated with Rheumatoid Arthritis

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Sources for Rheumatoid Arthritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet