RA
MCID: RHM011
MIFTS: 83

Rheumatoid Arthritis (RA) malady

Summaries for Rheumatoid Arthritis

Sources:
8Disease Ontology, 21Genetics Home Reference, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rheumatoid Arthritis, also known as rheumatoid arthritis, susceptibility to, is related to arthritis and juvenile rheumatoid arthritis. An important gene associated with Rheumatoid Arthritis is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Leishmaniasis and Immune System. The drugs chloroquine and chloroquine phosphate and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include joint, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

Genetics Home Reference:21 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

CDC:3 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Wikipedia:64 Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory... more...

Description from OMIM:47 180300

Aliases & Classifications for Rheumatoid Arthritis

Sources:
8Disease Ontology, 9diseasecard, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

rheumatoid arthritis 8 21 47 10 45 34 31 61
rheumatoid arthritis, susceptibility to 9 22
arthritis 8 61
polyarthritis, rheumatic 8
arthritis, rheumatoid 21
atrophic arthritis 8
ra 21


External Ids:

Disease Ontology8 DOID:7148
OMIM47 180300
ICD9CM27 714.0
MeSH35 D001172
ICD1025 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1109)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.9IL1A, IL17A, IL6
2juvenile rheumatoid arthritis32.1HLA-DRB1, IL1A, IL6, SLC11A1
3osteoarthritis31.7CCL2, SAA1, CTSK, IL1A, IL17A, IL6
4systemic lupus erythematosus31.6STAT4
5synovitis31.5IL6, IL17A, IL1A
6psoriatic arthritis31.3PTPN22, IL1A, HLA-DRB1
7amyloidosis31.3SAA1
8vasculitis31.2IL17A, CCL2
9tuberculosis31.2SLC11A1, IL17A, IL10, CIITA, HLA-DRB1
10atherosclerosis31.1CCL2, SAA1, CTSK, STAT4, CIITA, IL10
11polymyalgia rheumatica31.1HLA-DRB1
12uveitis31.0IL17A, IL1A, IL10, CCL2
13polymyositis30.8IL17A, IL1A
14hepatitis c30.8HLA-DRB1, CIITA, IL10
15asthma30.7CCL2, HLA-DRB1, STAT4, CIITA, IL10, IL17A
16bronchiolitis obliterans30.7IL17A
17crohn's disease30.7SLC22A4
18ulcerative colitis30.7HLA-DRB1, STAT4, IL10, IL1A, IL17A, IL6
19thyroiditis30.6PTPN22, CIITA, HLA-DRB1
20sjogren's syndrome30.6CIITA
21familial mediterranean fever30.5SAA1
22toxic shock syndrome30.5CIITA
23acute leukemia30.5IL17A
24systemic scleroderma30.4CCL2, HLA-DRB1, CIITA, IL1A, IL17A, PTPN22
25sepsis30.4IL6, IL17A, IL1A, IL10, CIITA, CCL2
26nephritis30.4IL17A, CCL2
27kaposi's sarcoma30.4IL6
28visceral leishmaniasis30.4SLC11A1, IL10
29graves' disease30.3HLA-DRB1, CIITA, IL1A, FCRL3, PTPN22
30atopic dermatitis30.3IL17A, IL1A, IL10, CCL2
31deficiency anemia30.3SAA1, IL6, SLC11A1
32pulmonary tuberculosis30.3HLA-DRB1, IL10, SLC11A1
33hepatitis b30.3IL17A, IL10, HLA-DRB1
34celiac disease30.3PTPN22, CIITA
35vitiligo30.3PTPN22, CIITA
36thrombocytopenia30.3IL6, IL1A
37lyme disease30.2CIITA
38septic shock30.2CIITA, IL10, IL1A, IL6
39pemphigus vulgaris30.2HLA-DRB1, CIITA, IL1A
40lupus nephritis30.2IL10, CIITA, CCL2
41alopecia areata30.2CIITA, IL1A
42atopy30.2SLC11A1, IL10
43wegener's granulomatosis30.2CIITA
44pulmonary disease, chronic obstructive30.2IL6
45pemphigus foliaceus30.2HLA-DRB1
46cystic fibrosis30.2IL17A
47allergic asthma30.2IL17A, IL10, CCL2
48coronary artery disease,30.0CCL2, SAA1, IL17A, IL6
49type 1 diabetes30.0IL10, CIITA, HLA-DRB1
50kawasaki disease30.0CIITA, CCL2

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Clinical Features for Rheumatoid Arthritis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

180300

Clinical synopsis from OMIM:

180300

Drugs & Therapeutics for Rheumatoid Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Rheumatoid Arthritis

Search NIH Clinical Center for Rheumatoid Arthritis

Highlights from CenterWatch's Drugs in Clinical Trials Database for Rheumatoid Arthritis:

idCompanyCompoundMechanismPhase
1TiGenix NVCx611Expanded allogeneic adult stem cell product derived from human adipose tissueIIa
2Lexicon PharmaceuticalsLX2931An orally available small molecule inhibitor of S1P lyaseII
3Janssen BiotechsirukumabA human monoclonal IgG1 kappa antibodyIII
4AstraZenecafostamatinibA mast cell macrophage and B-cell activation-blocking solid-dosage prodrug of an oral Syk kinase inhibitorIII
5Eli LillybaricitinibAn oral JAK1/JAK2 inhibitorIII

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Genetic Tests for Rheumatoid Arthritis

Sources:
22GTR
See all sources

Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis22

Anatomical Context for Rheumatoid Arthritis

Sources:
31LifeMap Discovery™, 14FMA
See all sources

FMA organs/tissues related to Rheumatoid Arthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Rheumatoid Arthritis

Sources:
51PubMed
See all sources

Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7204)
idTitleAuthorsYear
1
Non-tumor necrosis factor-based biologic therapies for rheumatoid arthritis: present, future, and insights into pathogenesis. (24353404)
2014
2
Comment on "visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate". (23532155)
2013
3
Host modulation in rheumatoid arthritis patients with TNF blockers significantly decreases biochemical parameters in periodontitis. (23649513)
2013
4
Management of biofilm control in an elderly patient suffering from rheumatoid arthritis: a case report. (24355237)
2013
5
Achieving consensus in ultrasonography synovitis scoring in rheumatoid arthritis. (24330219)
2013
6
Administration costs of intravenous biologic drugs for rheumatoid arthritis. (24255834)
2013
7
Evidence of the symptomatic and structural efficacy of methotrexate in daily practice as the first disease-modifying drug in rheumatoid arthritis despite its suboptimal use: results from the ESPOIR early synovitis cohort. (22661552)
2012
8
Involvement of IL-33 in the pathogenesis of rheumatoid arthritis: the effect of etanercept on the serum levels of IL-33. (21674220)
2012
9
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease. (22532634)
2012
10
Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. (19926672)
2010
11
A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis. (19734133)
2010
12
CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. (20032971)
2010
13
Cetuximab in the treatment of rheumatoid arthritis. (20051754)
2010
14
Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study. (18766426)
2009
15
The expression of PADI4 in synovium of rheumatoid arthritis. (19199100)
2009
16
Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis. (19714593)
2009
17
Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. (19627579)
2009
18
Copernican revolution in the therapy of rheumatoid arthritis: the contribution of anti-TNFalpha drugs]. (19999184)
2009
19
Budget impact model of rituximab after failure of one or more TNFalpha inhibitor therapies in the treatment of rheumatoid arthritis. (18951825)
2008
20
Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. (18759290)
2008
21
Rituximab: a new therapeutic alternative in rheumatoid arthritis. (18571968)
2008
22
Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. (18474811)
2008
23
Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies. (17888206)
2007
24
Risk: benefit profile of etanercept in elderly patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. (17362051)
2007
25
Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity. (16052592)
2005
26
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. (15641066)
2005
27
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. (15832289)
2005
28
Different threshold for prolactin response to hypoglycaemia in patients with rheumatoid arthritis? (15708916)
2005
29
Different familial association patterns of autoimmune diseases between juvenile-onset systemic lupus erythematosus and juvenile rheumatoid arthritis. (15181489)
2004
30
Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. (15225616)
2004
31
Subacute cutaneous lupus erythematosus in a patient with rheumatoid arthritis. (12492256)
2002
32
Tumour necrosis factor-alpha, interleukin-2 soluble receptor and different inflammatory parameters in patients with rheumatoid arthritis. (12581498)
2002
33
Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines. (11860615)
2002
34
NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy. (12546136)
2002
35
Prospective evaluation of the frequency and clinical significance of antineutrophil cytoplasmic and anticardiolipin antibodies in community cases of patients with rheumatoid arthritis. (10852977)
2000
36
Soluble cell adhesion molecules--P-selectin and ICAM-1, and disease activity in patients receiving sulphasalazine for active rheumatoid arthritis. (9751471)
1998
37
Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. (9676774)
1998
38
Methotrexate for resistant chronic uveitis in children with juvenile rheumatoid arthritis. (9709718)
1998
39
Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium. (9870879)
1998
40
Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees. (9133963)
1997
41
Trial of intravenous pulse cyclophosphamide and methylprednisolone in the treatment of severe systemic-onset juvenile rheumatoid arthritis. (9336421)
1997
42
Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis. (8856610)
1996
43
Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: anti-rheumatic activity by protease inhibition. (8929772)
1996
44
CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis. (8724289)
1996
45
Expression of neutrophil activation markers and neutrophil adhesion to chondrocytes in rheumatoid arthritis patients: relationship with disease activity. (7481076)
1995
46
Effect of T-activin and irradiation with a helium-neon laser on the status of the interleukin-2-dependent component of the proliferative response of mononuclear cells in rheumatoid arthritis]. (7589960)
1995
47
CDR3 length restriction of T-cell receptor beta chains in CD8+ T-cells of rheumatoid arthritis patients. (7645825)
1995
48
The relationship of haemoglobin to serum erythropoietin concentrations in the anaemia of rheumatoid arthritis: the effect of oral prednisolone. (8448609)
1993
49
Severe anemia associated with active systemic-onset juvenile rheumatoid arthritis successfully treated with recombinant human erythropoietin: a pilot study. (1599527)
1992
50
Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. (2174906)
1990

Genetic Variations for Rheumatoid Arthritis

Expression for genes affiliated with Rheumatoid Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rheumatoid Arthritis

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

Sources:
30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9IL6, HLA-DRB1, STAT4, CIITA, IL10, IL1A
2
Hide members
11.7SAA1, CTSK, HLA-DRB1, CIITA, IL1A, IL6
311.5IL6, IL1A, IL10, CIITA, HLA-DRB1
4
Hide members
11.5HLA-DRB1, CIITA, IL10, IL1A, IL6
5
Hide members
11.5CCL2, HLA-DRB1, CIITA, IL1A, IL6
6
Hide members
11.5CCL2, STAT4, IL10, IL1A, IL6
7
Hide members
11.5IL6, IL1A, IL10, STAT4, CCL2
8
Hide members
11.5CCL2, CTSK, STAT4, IL10, IL6
9
Development PDGF signaling via STATs and NF-kB
Hide members
11.5CCL2, STAT4, IL10, IL17A, IL6
10
Hide members
11.3HLA-DRB1, CIITA, IL1A, IL6
11
Hide members
11.3STAT4, IL10, IL17A, IL6
12
Hide members
11.3IL10, IL1A, IL17A, IL6
1311.1HLA-DRB1, IL1A, IL6
1411.1IL6, IL1A, IL10
1511.1IL6, IL1A, IL10
1611.1IL10, IL1A, IL6
17
Hide members
11.1IL6, IL17RA, STAT4
1811.1CCL2, SAA1, IL6
19
Cytokine production by Th17 cells in CF (Mouse model)
11.1IL17RA, IL17A, IL6
20
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
11.1IL17RA, IL17A, IL6
21
Hide members
11.1IL17A, IL17RA, IL1A
22
Hide members
10.7PTPN22
2310.7HLA-DRB1
2410.7CTSK

Compounds for genes affiliated with Rheumatoid Arthritis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.7CTSK, HLA-DRB1, STAT4, CIITA, CD244, IL17A
2nitric oxide45 11 2414.5CCL2, CIITA, IL10, IL1A, IL17A, IL6
3arginine4512.3CCL2, SAA1, HLA-DRB1, IL1A, SLC22A4, PADI4
4simvastatin45 50 60 29 11 2417.1CCL2, SAA1, CIITA, IL10, IL1A, IL6
5lipid4512.1CCL2, SAA1, CIITA, CD244, IL17A, IL6
6vegf4512.0CCL2, IL10, IL1A, IL17A, IL6, SERPINH1
7groalpha4511.9IL6, IL17A, IL1A, IL10, CCL2
8rantes4511.9CIITA, IL1A, IL17RA, IL17A, IL6
9sb 20358045 6012.9CCL2, IL10, IL1A, IL17A, IL6
10vitamin d4511.9SLC11A1, IL6, IL1A, IL10, CCL2
11ly2940024511.9CCL2, CD244, IL10, IL17A, IL6
12actinomycin d4511.8CCL2, CIITA, IL1A, IL17A, IL6
13il-124511.7IL6, IL10, STAT4, CCL2
14polymyxin b4511.7CCL2, IL10, IL1A, IL6
15polyinosinic-polycytidylic acid4511.7CIITA, IL10, IL1A, IL6
16il 104511.7CCL2, IL10, IL1A, IL6
17ccl345 2912.7CCL2, IL10, IL1A, IL6
18allergens4511.7HLA-DRB1, STAT4, CIITA, IL10
19corticosterone45 60 2413.7CCL2, IL10, IL1A, SLC22A4
20thymidine45 2412.6CIITA, IL10, IL1A, IL17A, IL6
21curcumin4511.6IL6, IL17A, IL1A, CCL2
22dexamethasone45 50 29 1114.5IL6, CIITA, SAA1
23toxin-14511.5CCL2, CIITA, IL10
24mcp 14511.5CCL2, IL10, IL6
25mip 1alpha4511.5IL6, IL10, CCL2
26methotrexate45 50 1113.5HLA-DRB1, IL10, IL17A, IL6
27cyclosporin a45 29 6013.5CIITA, IL17A, SERPINH1
28glatiramer acetate45 1112.5IL10, CIITA, HLA-DRB1
29mdms4511.5CCL2, CIITA, IL10
30imiquimod45 29 60 1114.5IL10, IL1A, IL6
31lipoteichoic acid4511.4CCL2, IL10, IL6
328-isoprostane4511.4IL6, IL10, CCL2
33etanercept45 50 1113.4IL10, IL17A, IL6
34infliximab45 50 1113.4IL6, IL17A, IL10
35tarc4511.3IL1A, IL10, CCL2
36endotoxin4511.3CIITA, SAA1
37peptidoglycan45 2912.3CIITA, IL10, IL6
38ivig4511.3IL6, IL1A, IL10
39tenidap45 2912.3IL1A, SAA1
40muramyl tripeptide4511.2IL1A, CCL2
41aspartate4511.2CCL2, CTSK, IL1A, SLC11A1
42iron sucrose4511.2CCL2, IL6
43ifn-alpha4511.2IL10, IL17A, IL6
44cdp5714511.2IL10, IL6
45gm-csf45 2912.1IL10
46fluvastatin45 50 29 1114.1CCL2, IL1A, IL6
4715-deoxy-delta-12,14-prostaglandin j24511.1IL6, IL10, CCL2
48aprotinin45 1112.1CTSK
49trinitrobenzenesulfonic acid4511.0IL17A, IL10
50neopterin4510.8IL6, IL1A, IL10

GO Terms for genes affiliated with Rheumatoid Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6SERPINH1, CCL2, CTSK, IL10, IL1A, IL17A
2external side of plasma membraneGO:00989711.3IL6, IL17A, CD244, HLA-DRB1

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594412.2STAT4, CIITA, IL10, IL1A, IL17A, IL6
2cytokine-mediated signaling pathwayGO:01922112.0IL6, IL1A, CIITA, STAT4, HLA-DRB1, CCL2
3inflammatory responseGO:00695412.0CCL2, IL10, IL1A, IL17A, IL6, SLC11A1
4positive regulation of cytokine secretionGO:05071511.4SAA1, IL10, IL1A
5response to antibioticGO:04667711.3IL6, CIITA, CCL2
6humoral immune responseGO:00695911.3IL6, BST1, CCL2
7fibroblast activationGO:07253711.1IL17RA, IL17A
8negative regulation of collagen biosynthetic processGO:03296611.1CIITA, IL6
9regulation of vascular endothelial growth factor productionGO:01057411.1CCL2, IL6
10positive regulation of interleukin-23 productionGO:03274711.0IL17A, IL17RA
11positive regulation of cytokine production involved in inflammatory responseGO:190001711.0IL17RA, IL17A
12response to glucocorticoid stimulusGO:05138411.0CCL2, IL10, IL6
13lymphocyte chemotaxisGO:04824711.0CCL2, SAA1
14positive regulation of MHC class II biosynthetic processGO:04534810.9CIITA, IL10
15macrophage chemotaxisGO:04824610.9SAA1, CCL2
16cellular response to lipopolysaccharideGO:07122210.8IL10, NFKBIL1, CCL2

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.3IL6, IL17A, IL1A, IL10

Products for genes affiliated with Rheumatoid Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatoid Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet