RA
MCID: RHM011
MIFTS: 94

Rheumatoid Arthritis (RA) malady

Bone diseases, Rare diseases, Respiratory diseases categories
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Summaries for Rheumatoid Arthritis

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MedlinePlus:33 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Rheumatoid Arthritis, also known as rheumatoid arthritis, susceptibility to, is related to arthritis and juvenile rheumatoid arthritis, and has symptoms including An important gene associated with Rheumatoid Arthritis is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are Lymphocyte Signaling and Hematopoietic cell lineage. The drugs chloroquine and chloroquine phosphate and the compounds groalpha and il-12 have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

Genetics Home Reference:21 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

CDC:3 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Wikipedia:65 Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints. It... more...

Description from OMIM:46 180300

Aliases & Classifications for Rheumatoid Arthritis

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Rheumatoid Arthritis, Aliases & Descriptions:

Name: Rheumatoid Arthritis 30 8 21 46 10 44 33 62
Rheumatoid Arthritis, Susceptibility to 9 22
Arthritis 8 62
Polyarthritis, Rheumatic 8
 
Arthritis, Rheumatoid 21
Atrophic Arthritis 8
Ra 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Respiratory diseases


External Ids:

Disease Ontology8 DOID:7148
ICD9CM27 714.0
MeSH34 D001172
OMIM46 180300
ICD1025 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1233)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis33.9IL17A, IL1A, IL6
2juvenile rheumatoid arthritis33.0IL1A, IL6, HLA-DRB1, SLC11A1
3osteoarthritis32.6CCL2, SAA1, IL1A, CTSK, IL6, IL17A
4systemic lupus erythematosus32.6STAT4
5synovitis32.5IL1A, IL17A, IL6
6psoriatic arthritis32.2IL1A, PTPN22, HLA-DRB1
7pneumonia32.2IL10, CCL2, IL17A, IL6
8periodontitis32.2IL6, IL10, IL17A, CCL2, IL1A
9atherosclerosis32.2IL17A, IL6, CTSK, IL1A, CCL2, CIITA
10tuberculosis32.1IL10, HLA-DRB1, IL17A, CIITA, SLC11A1
11uveitis32.0CCL2, IL17A, IL10, IL1A
12connective tissue disease32.0CCL2, PTPN22, HLA-DRB1, IL10, IL6
13psoriasis31.9IL6, IL10, CIITA, PTPN22, HLA-DRB1, IL1A
14thyroiditis31.8HLA-DRB1, PTPN22, CIITA
15leukemia31.8PADI4, HLA-DRB1, IL1A, BST1, IL17A, IL6
16colitis31.8IL6, IL17A, IL10, IL17RA
17periodontal disease31.8IL17A, IL1A, IL6
18crohn's disease31.7SLC22A4
19lymphopenia31.7PTPN22, CIITA, IL6, IL10
20asthma31.7SLC11A1, IL10, IL17A, HLA-DRB1, STAT4, CCL2
21ulcerative colitis31.6SLC11A1, IL1A, IL6, IL10, IL17A, STAT4
22hepatitis b31.6IL10, HLA-DRB1, IL17A
23diabetes mellitus31.6HLA-DRB1, PTPN22, CCL2, IL6
24hepatitis c31.6HLA-DRB1, CIITA, IL10
25multiple sclerosis31.6CCL2, IL17A, IL10, IL6, SLC11A1, STAT4
26pulmonary fibrosis31.5SERPINH1, CCL2, CTSK
27sepsis31.5CCL2, IL17A, IL10, IL6, CIITA, IL1A
28sarcoidosis31.5IL1A, SLC11A1, HLA-DRB1, CCL2
29gingivitis31.4IL1A, IL17A
30visceral leishmaniasis31.4SLC11A1, IL10
31pulmonary tuberculosis31.4IL10, HLA-DRB1, SLC11A1
32obesity31.4CTSK, CCL2, IL17A, IL6
33atopic dermatitis31.3IL17A, IL10, CCL2, IL1A
34inflammatory bowel disease31.3SLC22A4, IL6, IL10, IL17A, STAT4, SLC11A1
35graves' disease31.3IL1A, FCRL3, PTPN22, HLA-DRB1, CIITA
36pemphigus vulgaris31.3IL1A, HLA-DRB1, CIITA
37septic shock31.2IL10, IL1A, CIITA, IL6
38alopecia areata31.2CIITA, IL1A
39lupus nephritis31.2IL10, CIITA, CCL2
40vascular disease31.2IL10, IL6, IL1A
41leprosy31.1SLC11A1, HLA-DRB1
42allergic asthma31.1IL17A, CCL2, IL10
43chronic obstructive pulmonary disease31.1IL6, CCL2, IL17A
44endometriosis31.0IL17A, CCL2, IL1A, IL6
45ocular cicatricial pemphigoid31.0CIITA
46skin disease31.0IL17A, CIITA, IL10, IL1A
47idiopathic pulmonary fibrosis31.0CCL2, SERPINH1, IL1A
48systemic scleroderma31.0HLA-DRB1, PTPN22, SERPINH1, CCL2, IL17A, IL1A
49encephalitis30.9CCL2, CIITA, IL17A
50brucellosis30.9SLC11A1, SAA1

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Symptoms for Rheumatoid Arthritis

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Symptoms by clinical synopsis from OMIM:

180300

Clinical features from OMIM:

180300

HPO human phenotypes related to Rheumatoid Arthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707
2 rheumatoid arthritis HP:0001370
3 abnormality of blood and blood-forming tissues HP:0001871
4 abnormality of the respiratory system HP:0002086
5 vasculitis HP:0002633
6 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Rheumatoid Arthritis

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Genetic Tests for Rheumatoid Arthritis

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Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis22

Anatomical Context for Rheumatoid Arthritis

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MalaCards organs/tissues related to Rheumatoid Arthritis:

32
T cells, Bone, Monocytes, Endothelial, B cells, Lung, Neutrophil, Skin, Eye, Testes, Bone marrow, Myeloid, Heart, Thyroid, Liver, Pituitary, Kidney, Whole blood, Breast, Lymph node, Spleen, Brain, Salivary gland, Nk cells, Tongue, Thymus, Colon, Retina, Spinal cord, Smooth muscle, Small intestine, Placenta, Prostate, Tonsil

FMA organs/tissues related to Rheumatoid Arthritis:

14
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6SLC11A1, BST1, PTPN22, CIITA, PADI4, STAT4
2MP:000539710.6CCL2, STAT4, PADI4, CIITA, PTPN22, BST1
3MP:000538110.6PTPN22, SERPINH1, CCL2, IL17A, IL10, IL6
4MP:000537610.6PTPN22, CIITA, SAA1, STAT4, CCL2, IL17A
5MP:000538810.5PTPN22, SERPINH1, IL17A, IL17RA, IL10, IL6
6MP:000539010.4CTSK, IL6, IL10, IL17A, CCL2, SERPINH1
7MP:000200610.4CCL2, IL17RA, IL10, IL6, IL1A, SLC11A1
8MP:001076810.3PTPN22, SERPINH1, PADI4, STAT4, CCL2, IL17A
9MP:000537910.2PTPN22, CIITA, STAT4, IL10, IL6, CTSK

Publications for Rheumatoid Arthritis

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Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7254)
idTitleAuthorsYear
1
Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort. (25399388)
2014
2
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
3
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
4
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
5
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
6
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
2013
7
Response to: 'Comorbidities in a Mexican mestizo cohort with established rheumatoid arthritis' by Vega-Morales et al. (24336333)
2013
8
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. (24222719)
2013
9
Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. (23861880)
2013
10
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
11
Evaluation of disease activity indices in Korean patients with rheumatoid arthritis. (21305296)
2012
12
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
13
CIITA is not associated with risk of developing rheumatoid arthritis. (21248776)
2011
14
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
15
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
16
Novel TNF antagonists for the treatment of rheumatoid arthritis. (20001558)
2010
17
Association between the FCGR3A V158F polymorphism and the clinical response to infliximab in rheumatoid arthritis and spondyloarthritis patients. (20560817)
2010
18
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate. (20439295)
2010
19
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
20
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
21
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
22
Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. (19035425)
2008
23
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
24
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
25
Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis. (17265480)
2007
26
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. (17530710)
2007
27
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
28
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
29
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
30
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
31
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
32
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. (15248210)
2004
33
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
34
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
35
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
36
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
37
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
38
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
39
Enrichment of T cells carrying beta7 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. (9779846)
1998
40
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
41
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. (7551660)
1995
42
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. (7818564)
1995
43
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
48
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
49
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Rheumatoid Arthritis

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Clinvar genetic disease variations for Rheumatoid Arthritis:

6
id Gene Name Type Significance SNP ID Assembly Location
1CD244CD244, rs3766379undetermined variantrisk factor
2SLC22A4SLC22A4, IVS1, T-Csingle nucleotide variantrisk factor
3NFKBIL1NFKBIL1, -62T-Asingle nucleotide variantrisk factor
4PTPN22NM_015967.5(PTPN22): c.1858C> T (p.Arg620Trp)single nucleotide variantrisk factorrs2476601GRCh37Chr 1, 114377568: 114377568
5CIITAMHC2TA, -168A-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Rheumatoid Arthritis

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Expression patterns in normal tissues for genes affiliated with Rheumatoid Arthritis

Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

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Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5IL10, CIITA, PTPN22
210.5HLA-DRB1, IL6, IL1A
3
Show member pathways
10.5HLA-DRB1, CIITA, IL6, IL1A
410.5HLA-DRB1, CIITA, IL10, IL6, IL1A
5
Show member pathways
10.5HLA-DRB1, CIITA, IL10, IL6, IL1A
610.5HLA-DRB1, IL10, IL6, IL1A
710.5IL1A, IL6, IL10
810.5IL1A, IL6, IL10
910.5IL1A, IL6, IL10
1010.5IL1A, IL6, IL10
11
Show member pathways
10.5HLA-DRB1, CIITA, CCL2, IL6, IL1A
1210.5IL6, IL10, CCL2
13
Show member pathways
10.5PTPN22, CCL2, IL10, IL6, IL1A
14
Show member pathways
Type III interferon signaling37
10.5STAT4, IL10, IL6
1510.5IL1A, IL6, CCL2
16
Show member pathways
thioredoxin pathway37
10.5SAA1, CCL2, IL6
17
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.5IL17A, IL10, IL6, IL1A
18
Show member pathways
10.5IL17A, IL17RA, IL6
19
Show member pathways
10.5IL6, IL17RA, IL17A
20
Show member pathways
IL27-mediated signaling events37
10.5IL6, IL10, IL17A, STAT4
21
Show member pathways
10.4IL1A, HLA-DRB1, CIITA, STAT4, IL17A, IL10
22
Show member pathways
10.4STAT4, CCL2, IL10, IL6, IL1A
23
Show member pathways
10.4STAT4, CCL2, IL10, IL6, IL1A
24
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.4STAT4, CCL2, IL17A, IL10, IL6
25
Show member pathways
10.4IL6, IL17RA, IL17A, STAT4
2610.4HLA-DRB1, CCL2, IL17A, IL6, IL1A, CTSK
27
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.4STAT4, CCL2, IL10, IL6, CTSK
28
Show member pathways
10.4CCL2, IL17A, IL17RA, IL10, IL6, IL1A

Compounds for genes affiliated with Rheumatoid Arthritis

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Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1groalpha4410.9IL10, IL6, IL1A, CCL2, IL17A
2il-124410.9IL6, CCL2, STAT4, IL10
3polyinosinic-polycytidylic acid4410.9IL6, IL10, IL1A, CIITA
4polymyxin b4410.9IL1A, IL6, IL10, CCL2
5simvastatin44 50 61 28 24 1115.9CIITA, SAA1, IL1A, CCL2, IL10, IL6
6gm-csf44 2811.9IL1A, IL6, IL10, CCL2
7endotoxin4410.9IL1A, SAA1, IL6, IL10, CCL2, IL17A
8il 104410.9IL6, IL10, IL1A, CCL2
9rantes4410.9IL17A, CIITA, IL6, IL1A, IL10, IL17RA
10tenidap44 2811.9IL6, IL1A, SAA1
11nitric oxide44 24 1112.9CIITA, SERPINH1, CCL2, IL17A, IL10, IL6
12arginine4410.9PADI4, SLC22A4, SAA1, IL1A, PTPN22, HLA-DRB1
13ccl344 2811.9CCL2, IL10, IL6, IL1A
14cyclosporin a44 28 6112.9IL1A, IL6, IL10, IL17A, SERPINH1, CIITA
15allergens4410.9IL10, STAT4, HLA-DRB1, CIITA
16dexamethasone44 50 28 1113.9IL6, SAA1, STAT4, CCL2, IL17A, IL10
17glatiramer acetate44 1111.9IL10, CIITA, HLA-DRB1
18mcp 14410.9CCL2, IL6, IL10
19toxin-14410.9IL10, CCL2, CIITA
20pge24410.9IL1A, IL6, IL10, IL17A, CIITA, CCL2
21tyrosine4410.9HLA-DRB1, CIITA, SERPINH1, STAT4, IL17A, CD244
22mip 1alpha4410.9CCL2, IL10, IL6
23mdms4410.8CCL2, CIITA, IL10
24aprotinin44 1111.8CTSK, IL1A, IL6, IL10
25corticosterone44 61 2412.8IL1A, SLC22A4, CCL2, IL10
26imiquimod44 61 28 1113.8IL1A, IL6, IL10
27sb 20358044 6111.8IL6, IL17A, IL1A, CCL2, IL10
28vitamin d4410.8IL6, SLC11A1, IL1A, CCL2, IL10
29ly2940024410.8CD244, IL6, IL10, IL17A, CCL2
30lipoteichoic acid4410.8IL6, IL10, CCL2
31actinomycin d4410.8CCL2, IL17A, IL6, IL1A, CIITA
328-isoprostane4410.8CCL2, IL10, IL6
33vegf4410.8CCL2, SERPINH1, IL1A, IL6, IL10, IL17A
34lipid4410.8CCL2, IL17A, CIITA, IL6, SLC22A4, CD244
35etanercept44 50 1112.8IL17A, IL10, IL6
36curcumin4410.8IL1A, IL6, IL17A, CCL2
37muramyl tripeptide4410.7CCL2, IL1A
38thymidine44 2411.7CIITA, IL17A, IL10, IL6, IL1A
39iron sucrose4410.7CCL2, IL6
40aspartate4410.7SLC11A1, IL1A, IL10, CCL2, CTSK
41methotrexate50 44 1112.7IL17A, HLA-DRB1, IL10, IL6
42tarc4410.7IL1A, IL10, CCL2
43infliximab44 50 1112.6IL17A, IL10, IL6
44peptidoglycan44 2811.6IL10, IL6, CIITA
45ivig4410.6IL6, IL10, IL1A
46pentoxifylline44 1111.5IL1A, IL6, IL10
47fluvastatin44 50 28 1113.5IL6, CCL2, IL1A
48cycloheximide4410.5CIITA, IL1A, IL10, IL6, CCL2
49cdp5714410.4IL6, IL10
50ifn-alpha4410.2IL17A, IL10, IL6

GO Terms for genes affiliated with Rheumatoid Arthritis

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Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4SAA1, CCL2, IL17RA, IL6, IL1A, CTSK
2extracellular spaceGO:00561510.3IL6, IL17A, IL1A, CTSK, CCL2, SERPINH1
3external side of plasma membraneGO:00989710.2CD244, IL6, IL17A, HLA-DRB1

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:04667710.8IL6, CCL2, CIITA
2cytokine-mediated signaling pathwayGO:01922110.8IL1A, HLA-DRB1, CIITA, STAT4, CCL2, IL17RA
3positive regulation of cytokine secretionGO:05071510.8SAA1, IL10, IL1A
4inflammatory responseGO:00695410.8CIITA, CCL2, IL17A, IL10, IL6, IL1A
5negative regulation of collagen biosynthetic processGO:03296610.8IL6, CIITA
6regulation of vascular endothelial growth factor productionGO:01057410.8IL6, CCL2
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.8CIITA, STAT4, IL17A, IL10, IL6, IL1A
8fibroblast activationGO:07253710.8IL17A, IL17RA
9humoral immune responseGO:00695910.8IL6, CCL2, BST1
10positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, CIITA
11positive regulation of interleukin-23 productionGO:03274710.8IL17A, IL17RA
12lymphocyte chemotaxisGO:04824710.8CCL2, SAA1
13positive regulation of cytokine production involved in inflammatory responseGO:190001710.7IL17RA, IL17A
14cellular response to lipopolysaccharideGO:07122210.7CCL2, IL10, NFKBIL1
15response to glucocorticoidGO:05138410.7IL6, IL10, CCL2
16immune responseGO:00695510.7IL1A, IL17A, CIITA, HLA-DRB1
17agingGO:00756810.7CIITA, CCL2, IL6
18macrophage chemotaxisGO:04824610.7CCL2, SAA1
19defense response to protozoanGO:04283210.6SLC11A1, IL6
20monocyte chemotaxisGO:00254810.6CCL2, IL6
21response to bacteriumGO:00961710.6SLC11A1, CCL2
22response to interferon-gammaGO:03434110.5CIITA, SLC11A1
23defense response to Gram-negative bacteriumGO:05082910.5SLC11A1, IL6
24JAK-STAT cascadeGO:00725910.5CCL2, STAT4
25response to amino acidGO:04320010.4IL6, CCL2
26negative regulation of interferon-gamma productionGO:03268910.2IL10, HLA-DRB1

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.5IL1A, IL6, IL10, IL17A

Products for genes affiliated with Rheumatoid Arthritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet