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MCID: RHM011
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Rheumatoid Arthritis malady |
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43 drugs, 1415 genes, 31 tissues, 956 related diseases, 29 phenotypes, 4317 articles, clinical trials.
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Sources: 6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts between ages 25 and 55. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime.
rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues.
no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling.
nih: national institute of arthritis and musculoskeletal and skin diseases23
MalaCards: Rheumatoid Arthritis, also known as arthritis, is related to carcinoma and leukemia. An important gene associated with Rheumatoid Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Antioxidant Action of Vitamin-C and Akt Signaling. The drugs diflunisal and gold and the compounds atp and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include joint, bone marrow and whole blood, and related mouse phenotypes are homeostasis/metabolism and cellular. Disease Ontology: An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.6 CDC: Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.2 Wikipedia: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and...44 more... OMIM: 180300 |
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Sources: 6Disease Ontology, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 2CDC, 43UMLS, 27NCIt, 40SNOMED-CT, 24MeSH, 19ICD9CM See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 180300
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for rheumatoid arthritis Drug clinical trials:Search ClinicalTrials for rheumatoid arthritis Search NIH Clinical Center for rheumatoid arthritis Search CenterWatch for rheumatoid arthritis Inferred drug relations via UMLS/NDF-RT:43 28 acetylsalicylate sodium, adalimumab, anakinra, aspirin, aspirin pwdr [va product], auranofin, azathioprine, captopril, celecoxib, chloroquine, chloroquine hydrochloride, chloroquine phosphate, choline salicylate, devils claw, diflunisal, enalapril, enalapril maleate, enalaprilat, etodolac, fenoprofen, fenoprofen calcium, fish oil, flurbiprofen, flurbiprofen sodium, gold, gold sodium thiomalate, hydroxychloroquine, hydroxychloroquine sulfate, indomethacin, indomethacin pwdr [va product], indomethacin sodium, ketoprofen, ketoprofen pwdr [va product], leflunomide, meclofenamate, meclofenamate sodium, nabumetone, penicillamine, piroxicam, salsalate, sulindac, thalidomide, valdecoxibCell-based therapeutics: The database of embryonic development, stem cell research and regenerative medicine Stem-Cell-Based therapeutic approaches for rheumatoid arthritis:
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Sources: 21LifeMap Discovery™, 11FMA, 22MalaCards See all sources |
MalaCards organs/tissues related to rheumatoid arthritis:22Bone marrow, Whole blood, Lymph node, Spleen, Brain, Heart, Smooth muscle, Small intestine, Kidney, Liver, Lung, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Placenta, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pituitary FMA organs/tissues related to rheumatoid arthritis:11Joint The database of embryonic development, stem cell research and regenerative medicine Embryonic and adult cells/anatomical compartments related to rheumatoid arthritis:
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to rheumatoid arthritis:25 (show all 29)
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Sources: 35PubMed See all sources |
Articles related to rheumatoid arthritis:(show top 50) (show all 4317)
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 20KEGG, 3Cell Signaling Technology, 37R&D Systems, 41Thomson Reuters, 10EMD Millipore See all sources |
Pathways related to rheumatoid arthritis according to GeneDecks:(show top 50) (show all 284)
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Sources: 32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience See all sources |
Compounds related to rheumatoid arthritis according to GeneDecks:(show top 50) (show all 470)
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Sources: 12Gene Ontology See all sources |
Cellular components related to rheumatoid arthritis according to GeneDecks:(show all 14)
Biological processes related to rheumatoid arthritis according to GeneDecks:(show top 50) (show all 84)
Molecular functions related to rheumatoid arthritis according to GeneDecks:(show all 13)
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