MCID: RHM011
MIFTS: 96

Rheumatoid Arthritis malady

Genetic diseases, Bone diseases, Rare diseases categories

Summaries for Rheumatoid Arthritis

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MedlinePlus:34 Rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. but children and young adults can also get it. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment and hormones might contribute. treatments include medicine, lifestyle changes and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Rheumatoid Arthritis, also known as arthritis, rheumatoid, is related to arthritis and juvenile rheumatoid arthritis, and has symptoms including abnormality of the nervous system, rheumatoid arthritis and abnormality of blood and blood-forming tissues. An important gene associated with Rheumatoid Arthritis is IL10 (interleukin 10), and among its related pathways are Allograft rejection and Tuberculosis. The drugs meclofenamate sodium and salsalate and the compounds endotoxin and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include joint, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:10 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

CDC:4 Rheumatoid arthritis (RA) causes premature mortality, disability and compromised quality of life in the industrialized and developing world (1). Rheumatoid arthritis is a systemic inflammatory disease which manifests itself in multiple joints of the body. The inflammatory process primarily affects the lining of the joints (synovial membrane), but can also affect other organs. The inflamed synovium leads to erosions of the cartilage and bone and sometimes joint deformity. Pain, swelling, and redness are common joint manifestations. Although the causes are unknown, RA is believed to be the result of a faulty immune response. RA can begin at any age and is associated with fatigue and prolonged stiffness after rest. There is no cure for RA, but new effective drugs are increasingly available to treat the disease and prevent deformed joints. In addition to medications and surgery, good self-management, including exercise, are known to reduce pain and disability.

Genetics Home Reference:23 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

OMIM:47 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex... (180300) more...

Wikipedia:65 Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that primarily affects joints. It... more...

Aliases & Classifications for Rheumatoid Arthritis

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Rheumatoid Arthritis, Aliases & Descriptions:

Name: Rheumatoid Arthritis 47 32 10 23 12 45 34 4 62
Arthritis, Rheumatoid 23 24
Arthritis 10 62
Ra 23 4
 
Rheumatoid Arthritis, Susceptibility to 11
Rheumatoid Arthritis, Progression of 47
Polyarthritis, Rheumatic 10
Atrophic Arthritis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases


External Ids:

OMIM47 180300
Disease Ontology10 DOID:7148
ICD9CM29 714.0
MeSH35 D001172
ICD1027 M05.3, M06.8

Related Diseases for Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1199)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis33.1IL1A, IL6, IL17A
2juvenile rheumatoid arthritis32.2HLA-DRB1, IL6, IL1A, SLC11A1
3osteoarthritis31.9PADI4, SAA1, CCL2, IL17A, IL6, IL1A
4systemic lupus erythematosus31.8STAT4
5synovitis31.7IL17A, IL6, IL1A
6psoriatic arthritis31.5HLA-DRB1, PTPN22, IL1A
7pneumonia31.4CCL2, IL17A, IL10, IL6
8tuberculosis31.3HLA-DRB1, CIITA, IL17A, IL10, SLC11A1
9periodontitis31.3CCL2, IL17A, IL10, IL6, IL1A
10atherosclerosis31.3CIITA, SAA1, STAT4, CCL2, IL17A, IL10
11leukemia31.2IL1A, IL6, IL17A, PADI4, HLA-DRB1, BST1
12uveitis31.1CCL2, IL17A, IL10, IL1A
13connective tissue disease31.1HLA-DRB1, PTPN22, CCL2, IL10, IL6
14psoriasis31.1HLA-DRB1, PTPN22, CIITA, CCL2, IL17A, IL10
15thyroiditis31.1HLA-DRB1, PTPN22, CIITA
16crohn's disease31.0SLC22A4
17periodontal disease31.0IL17A, IL6, IL1A
18colitis31.0IL17A, IL17RA, IL10, IL6
19asthma30.9HLA-DRB1, CIITA, STAT4, CCL2, IL17A, IL10
20gingivitis30.9IL17A, IL1A
21hepatitis c30.8IL10, CIITA, HLA-DRB1
22hepatitis b30.8IL10, IL17A, HLA-DRB1
23lymphopenia30.8PTPN22, CIITA, IL10, IL6
24ulcerative colitis30.8HLA-DRB1, STAT4, IL17A, IL10, IL6, IL1A
25pulmonary fibrosis30.7SERPINH1, CCL2, CTSK
26vascular disease30.7IL1A, IL6, IL10
27inflammatory bowel disease30.7PTPN22, CIITA, STAT4, CCL2, IL17A, IL10
28obesity30.7CCL2, IL17A, IL6, CTSK
29visceral leishmaniasis30.6SLC11A1, IL10
30pulmonary tuberculosis30.6HLA-DRB1, IL10, SLC11A1
31atopic dermatitis30.5IL1A, IL10, IL17A, CCL2
32graves' disease30.5IL1A, CIITA, FCRL3, PTPN22, HLA-DRB1
33pemphigus vulgaris30.5IL1A, CIITA, HLA-DRB1
34alcoholic hepatitis30.4CCL2, IL1A
35alopecia areata30.4IL1A, CIITA
36lupus nephritis30.4CIITA, CCL2, IL10
37leprosy30.4SLC11A1, HLA-DRB1
38allergic asthma30.4CCL2, IL17A, IL10
39brucellosis30.2SAA1, SLC11A1
40endometriosis30.2IL1A, IL6, IL17A, CCL2
41ocular cicatricial pemphigoid30.2CIITA
42systemic scleroderma30.1HLA-DRB1, PTPN22, CIITA, SERPINH1, CCL2, IL17A
43skin disease30.1IL1A, IL10, IL17A, CIITA
44coronary artery disease30.1IL6, IL17A, CCL2, SAA1
45encephalitis30.1CIITA, CCL2, IL17A
46kawasaki disease30.1CCL2, CIITA
47congenital heart disease29.8IL6, IL10, CCL2
48sarcoidosis 129.7SLC11A1, IL1A, CCL2, HLA-DRB1
49bacterial vaginosis29.7SERPINH1, IL1A
50chorioamnionitis29.7IL6, SERPINH1

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to rheumatoid arthritis

Symptoms for Rheumatoid Arthritis

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Symptoms by clinical synopsis from OMIM:

180300

Clinical features from OMIM:

180300

HPO human phenotypes related to Rheumatoid Arthritis:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707
2 rheumatoid arthritis HP:0001370
3 abnormality of blood and blood-forming tissues HP:0001871
4 abnormality of the respiratory system HP:0002086
5 vasculitis HP:0002633
6 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Rheumatoid Arthritis

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Genetic Tests for Rheumatoid Arthritis

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Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis24

Anatomical Context for Rheumatoid Arthritis

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MalaCards organs/tissues related to Rheumatoid Arthritis:

33
T cells, Bone, Endothelial, Monocytes, B cells, Neutrophil, Lung, Skin, Eye, Bone marrow, Testes, Heart, Myeloid, Thyroid, Smooth muscle, Liver, Pituitary, Kidney, Whole blood, Spleen, Brain, Colon, Breast, Lymph node, Adipocyte, Tongue, Salivary gland, Nk cells, Thymus, Small intestine, Retina, Spinal cord, Placenta, Prostate, Tonsil

FMA organs/tissues related to Rheumatoid Arthritis:

16
Joint

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id TissueAnatomical CompartmentCell Relevance
1 CartilageTemporomandibular Joint  Affected by disease

Animal Models for Rheumatoid Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7SLC11A1, BST1, PTPN22, CIITA, PADI4, STAT4
2MP:000539710.7CCL2, STAT4, PADI4, CIITA, PTPN22, BST1
3MP:000537610.7PTPN22, CIITA, SAA1, STAT4, CCL2, IL17A
4MP:000538110.6PTPN22, SERPINH1, CCL2, IL17A, IL10, IL6
5MP:000538810.6PTPN22, SERPINH1, IL17A, IL17RA, IL10, IL6
6MP:000200610.5CCL2, IL17RA, IL10, IL6, IL1A, SLC11A1
7MP:000539010.5CTSK, IL6, IL10, IL17A, CCL2, SERPINH1
8MP:001076810.4PTPN22, SERPINH1, PADI4, STAT4, CCL2, IL17A
9MP:000537910.2PTPN22, CIITA, STAT4, IL10, IL6, CTSK

Publications for Rheumatoid Arthritis

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Articles related to Rheumatoid Arthritis:

(show top 50)    (show all 7316)
idTitleAuthorsYear
1
Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. (25727025)
2015
2
Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort. (25399388)
2014
3
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
4
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
5
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
6
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
7
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
2013
8
Response to: 'Comorbidities in a Mexican mestizo cohort with established rheumatoid arthritis' by Vega-Morales et al. (24336333)
2013
9
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis. (24222719)
2013
10
Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis. (23861880)
2013
11
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
12
Evaluation of disease activity indices in Korean patients with rheumatoid arthritis. (21305296)
2012
13
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
14
CIITA is not associated with risk of developing rheumatoid arthritis. (21248776)
2011
15
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
16
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
17
Novel TNF antagonists for the treatment of rheumatoid arthritis. (20001558)
2010
18
Association between the FCGR3A V158F polymorphism and the clinical response to infliximab in rheumatoid arthritis and spondyloarthritis patients. (20560817)
2010
19
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate. (20439295)
2010
20
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
21
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
22
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
23
Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. (19035425)
2008
24
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
25
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
26
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. (17530710)
2007
27
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
28
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
29
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
30
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
31
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
32
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. (15248210)
2004
33
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
34
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
35
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
36
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
37
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
38
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
39
Enrichment of T cells carrying beta7 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis. (9779846)
1998
40
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
41
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis. (7551660)
1995
42
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. (7818564)
1995
43
Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. (8575840)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
48
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
49
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Rheumatoid Arthritis

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UniProtKB/Swiss-Prot genetic disease variations for Rheumatoid Arthritis:

64
id Symbol AA change Variation ID SNP ID
1PTPN22p.Arg620TrpVAR_022605rs2476601

Clinvar genetic disease variations for Rheumatoid Arthritis:

7
id Gene Variation Type Significance SNP ID Assembly Location
1CD244CD244, rs3766379undetermined variantrisk factor
2SLC22A4SLC22A4, IVS1, T-Csingle nucleotide variantrisk factor
3NFKBIL1NFKBIL1, -62T-Asingle nucleotide variantrisk factor
4PTPN22NM_015967.5(PTPN22): c.1858C> T (p.Arg620Trp)single nucleotide variantrisk factorrs2476601GRCh37Chr 1, 114377568: 114377568
5CIITAMHC2TA, -168A-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Rheumatoid Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Rheumatoid Arthritis patients vs. healthy controls: 32 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Cartilage-7.130.000
2ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideCartilage-5.820.000
3FOSBFBJ murine osteosarcoma viral oncogene homolog BCartilage-5.350.000
4ANGPTL7angiopoietin-like 7Cartilage-5.080.000
5PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Cartilage-5.070.000
6FAM107Afamily with sequence similarity 107, member ACartilage-4.850.000
7APODapolipoprotein DCartilage-4.400.000
8FKBP5FK506 binding protein 5Cartilage-4.090.002
9PLIN1perilipin 1Cartilage-4.040.000
10NPAS2neuronal PAS domain protein 2Cartilage-4.010.000
11DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedCartilage-3.910.023
12MAOAmonoamine oxidase ACartilage-3.850.000
13ZBTB16zinc finger and BTB domain containing 16Cartilage-3.840.000
14ADCY2adenylate cyclase 2 (brain)Cartilage-3.830.000
15TOX3TOX high mobility group box family member 3Cartilage-3.780.005
16GDF15growth differentiation factor 15Cartilage-3.740.000
17LMOD1leiomodin 1 (smooth muscle)Cartilage-3.650.000
18TRHDEthyrotropin-releasing hormone degrading enzymeCartilage-3.610.000
19LEPleptinCartilage-3.480.000
20MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FCartilage-3.410.000
21ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideCartilage-3.400.000
22NR4A2nuclear receptor subfamily 4, group A, member 2Cartilage-3.380.000
23NFIL3nuclear factor, interleukin 3 regulatedCartilage-3.360.000
24JUNjun proto-oncogeneCartilage-3.340.001
25PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Cartilage-3.330.000
26TIMP4TIMP metallopeptidase inhibitor 4Cartilage-3.290.000
27PER1period circadian clock 1Cartilage-3.270.000
28ADIPOQadiponectin, C1Q and collagen domain containingCartilage-3.240.001
29FABP4fatty acid binding protein 4, adipocyteCartilage-3.220.000
30LAMA2laminin, alpha 2Cartilage-3.210.000
31TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)Cartilage-3.210.000
32ATF3activating transcription factor 3Cartilage-3.190.000
33EIF1AYeukaryotic translation initiation factor 1A, Y-linkedCartilage-3.170.023
34RRADRas-related associated with diabetesCartilage-3.150.000
35MYOCmyocilin, trabecular meshwork inducible glucocorticoid responseCartilage-3.140.000
36C7complement component 7Cartilage-3.130.000
37MYH11myosin, heavy chain 11, smooth muscleCartilage-3.130.001
38GADD45Agrowth arrest and DNA-damage-inducible, alphaCartilage-3.120.000
39TET2tet methylcytosine dioxygenase 2Blood+3.120.000
40LIFleukemia inhibitory factorCartilage-3.110.009
41RERGLRERG/RAS-likeCartilage-3.110.000
42GADD45Bgrowth arrest and DNA-damage-inducible, betaCartilage-3.100.000
43RPS4Y1ribosomal protein S4, Y-linked 1Cartilage-3.080.026
44GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Cartilage+3.080.000
45ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Cartilage+3.070.000
46ADMadrenomedullinCartilage-3.070.000
47UCP2uncoupling protein 2 (mitochondrial, proton carrier)Cartilage+3.060.000
48AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Cartilage-3.050.000
49KLF4Kruppel-like factor 4 (gut)Cartilage-3.050.000
50TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Cartilage-3.040.000
51EIF1eukaryotic translation initiation factor 1Cartilage-3.030.003
52AIF1allograft inflammatory factor 1Cartilage+3.030.000
53CORO1Acoronin, actin binding protein, 1ACartilage+3.020.000
54PDK4pyruvate dehydrogenase kinase, isozyme 4Cartilage-3.020.027
55RAMP2receptor (G protein-coupled) activity modifying protein 2Cartilage-3.020.004
56CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Cartilage+3.000.000
57CCDC102Bcoiled-coil domain containing 102BCartilage+3.000.000
58MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2Cartilage-3.000.000
59LEF1lymphoid enhancer-binding factor 1Cartilage+3.000.000
60NOVA1neuro-oncological ventral antigen 1Cartilage-2.980.004
61STAT1signal transducer and activator of transcription 1, 91kDaCartilage+2.960.000
62PTPRCAPprotein tyrosine phosphatase, receptor type, C-associated proteinCartilage+2.960.000
63RRM2ribonucleotide reductase M2Cartilage+2.940.000
64CYR61cysteine-rich, angiogenic inducer, 61Cartilage-2.940.000
65TARPTCR gamma alternate reading frame proteinCartilage+2.930.000
66PPP1R15Aprotein phosphatase 1, regulatory subunit 15ACartilage-2.920.000
67ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)Cartilage+2.910.000
68CEBPDCCAAT/enhancer binding protein (C/EBP), deltaCartilage-2.900.000
69FNDC4fibronectin type III domain containing 4Cartilage-2.890.000
70GFRA2GDNF family receptor alpha 2Cartilage+2.890.000
71FOSL2FOS-like antigen 2Cartilage-2.880.000
72SLC19A2solute carrier family 19 (thiamine transporter), member 2Cartilage-2.870.000
73PTX3pentraxin 3, longCartilage-2.870.007
74SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans)Cartilage+2.850.000
75PLA2G2Dphospholipase A2, group IIDCartilage+2.840.004
76KIF20Akinesin family member 20ACartilage+2.830.000
77CIITAclass II, major histocompatibility complex, transactivatorCartilage+2.830.000
78HLA-DPA1major histocompatibility complex, class II, DP alpha 1Cartilage+2.830.000
79H3F3BH3 histone, family 3B (H3.3B)Cartilage-2.830.000
80OSBPL3oxysterol binding protein-like 3Cartilage+2.820.000
81LTBlymphotoxin beta (TNF superfamily, member 3)Cartilage+2.820.000
82ATP2A3ATPase, Ca++ transporting, ubiquitousCartilage+2.810.000
83EGR1early growth response 1Cartilage-2.790.000
84SORL1sortilin-related receptor, L(DLR class) A repeats containingCartilage+2.790.000
85CD2CD2 moleculeCartilage+2.760.000
86CECR1cat eye syndrome chromosome region, candidate 1Cartilage+2.760.000
87SORBS1sorbin and SH3 domain containing 1Cartilage-2.760.000
88APLNRapelin receptorCartilage+2.760.000
89SLAMF8SLAM family member 8Cartilage+2.760.000
90FADS1fatty acid desaturase 1Cartilage-2.750.006
91MAST1microtubule associated serine/threonine kinase 1Cartilage+2.750.000
92ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Cartilage+2.750.000
93GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)Cartilage+2.750.002
94CR1complement component (3b/4b) receptor 1 (Knops blood group)Cartilage+2.740.002
95LAMA3laminin, alpha 3Cartilage-2.730.002
96HLA-DMBmajor histocompatibility complex, class II, DM betaCartilage+2.730.000
97KLF9Kruppel-like factor 9Cartilage-2.730.000
98GPR65G protein-coupled receptor 65Cartilage+2.720.001
99IL27RAinterleukin 27 receptor, alphaCartilage+2.710.002
100FOSL1FOS-like antigen 1Cartilage-2.710.026
101FAPfibroblast activation protein, alphaCartilage+2.700.002
1026-Sepseptin 6Cartilage+2.680.000
103BMP2KBMP2 inducible kinaseCartilage+2.680.001
104MS4A1membrane-spanning 4-domains, subfamily A, member 1Cartilage+2.670.005
105BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Cartilage+2.670.000
106SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Cartilage-2.660.003
107LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3Cartilage+2.660.000
108LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood+2.660.000
109DUOX2dual oxidase 2Cartilage-2.660.003
110MTSS1metastasis suppressor 1Cartilage-2.660.000
111CXCL11chemokine (C-X-C motif) ligand 11Cartilage+2.660.011
112NR4A1nuclear receptor subfamily 4, group A, member 1Cartilage-2.650.002
113LDLRlow density lipoprotein receptorCartilage-2.650.005
114SDC3syndecan 3Cartilage+2.640.000
115PMAIP1phorbol-12-myristate-13-acetate-induced protein 1Cartilage-2.640.005
116MT1Mmetallothionein 1MCartilage-2.630.000
117RTP4receptor (chemosensory) transporter protein 4Cartilage+2.630.000
118ZEB1zinc finger E-box binding homeobox 1Cartilage-2.620.001
119SLC12A8solute carrier family 12, member 8Cartilage+2.620.000
120CEP55centrosomal protein 55kDaCartilage+2.620.000
121PPAP2Bphosphatidic acid phosphatase type 2BCartilage-2.620.000
122BTN3A3butyrophilin, subfamily 3, member A3Cartilage+2.620.000
123IFI6interferon, alpha-inducible protein 6Blood+2.620.000
124TLR8toll-like receptor 8Cartilage+2.620.010
125CXCL6chemokine (C-X-C motif) ligand 6Cartilage+2.610.001
126RHOHras homolog family member HCartilage+2.600.002
127AIM2absent in melanoma 2Cartilage+2.600.000
128FLRT2fibronectin leucine rich transmembrane protein 2Cartilage+2.590.000
129CXCL5chemokine (C-X-C motif) ligand 5Cartilage+2.590.010
130HAS1hyaluronan synthase 1Cartilage-2.570.004
131SYKspleen tyrosine kinaseCartilage+2.560.000
132CD3DCD3d molecule, delta (CD3-TCR complex)Cartilage+2.560.000
133AOAHacyloxyacyl hydrolase (neutrophil)Cartilage+2.560.003
134ABCF2ATP-binding cassette, sub-family F (GCN20), member 2Cartilage-2.560.000
135CXCL9chemokine (C-X-C motif) ligand 9Cartilage+2.550.002
136HN1hematological and neurological expressed 1Cartilage+2.550.001
137BMP5bone morphogenetic protein 5Cartilage-2.540.020
138ACADLacyl-CoA dehydrogenase, long chainCartilage-2.540.001
139MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Cartilage+2.530.014
140LRMPlymphoid-restricted membrane proteinCartilage+2.520.001
141HBEGFheparin-binding EGF-like growth factorCartilage-2.520.004
142JUNDjun D proto-oncogeneCartilage-2.520.002
143C10orf10chromosome 10 open reading frame 10Cartilage-2.520.000
144SH2D1ASH2 domain containing 1ACartilage+2.520.004
145TNFSF11tumor necrosis factor (ligand) superfamily, member 11Cartilage+2.520.013
146PPP1R16Bprotein phosphatase 1, regulatory subunit 16BCartilage+2.510.000
147GPX3glutathione peroxidase 3 (plasma)Cartilage-2.510.000
148MYCv-myc avian myelocytomatosis viral oncogene homologCartilage-2.500.000
149SOCS3suppressor of cytokine signaling 3Cartilage-2.500.001
150DAZLdeleted in azoospermia-likeCartilage+2.500.000
151APOBEC3Fapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3FCartilage+2.500.000
152CD37CD37 moleculeCartilage+2.490.006
153DUSP1dual specificity phosphatase 1Cartilage-2.490.007
154IRS2insulin receptor substrate 2Cartilage-2.490.000
155CD58CD58 moleculeCartilage+2.490.001
156PITX1paired-like homeodomain 1Cartilage-2.480.012
157EPHB2EPH receptor B2Cartilage+2.470.000
158NPY1Rneuropeptide Y receptor Y1Cartilage-2.470.017
159KLRD1killer cell lectin-like receptor subfamily D, member 1Cartilage+2.470.000
160APOLD1apolipoprotein L domain containing 1Cartilage-2.470.000
161CNN1calponin 1, basic, smooth muscleCartilage-2.460.003
162ARCactivity-regulated cytoskeleton-associated proteinCartilage-2.450.018
163FIGFc-fos induced growth factor (vascular endothelial growth factor D)Cartilage-2.440.003
164CST7cystatin F (leukocystatin)Cartilage+2.440.000
165P2RY13purinergic receptor P2Y, G-protein coupled, 13Cartilage+2.430.022
166AOX1aldehyde oxidase 1Cartilage-2.430.025
167IKZF1IKAROS family zinc finger 1 (Ikaros)Cartilage+2.430.002
168AASSaminoadipate-semialdehyde synthaseCartilage-2.430.000
169PLNphospholambanCartilage-2.420.014
170TCEAL2transcription elongation factor A (SII)-like 2Cartilage-2.420.000
171KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Cartilage+2.420.011
172TGFBR3transforming growth factor, beta receptor IIICartilage-2.420.000
173CRIP1cysteine-rich protein 1 (intestinal)Cartilage+2.410.000
174BTN3A1butyrophilin, subfamily 3, member A1Cartilage+2.410.004
175TLR7toll-like receptor 7Cartilage+2.410.001
176IGLV4-60immunoglobulin lambda variable 4-60Cartilage+2.400.011
177LPLlipoprotein lipaseCartilage-2.400.008
178CDK5cyclin-dependent kinase 5Cartilage+2.400.001
179TMOD1tropomodulin 1Cartilage-2.390.015
180ICAM3intercellular adhesion molecule 3Cartilage+2.380.000
181CD27CD27 moleculeCartilage+2.370.000
182ST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1Cartilage+2.370.009
183AGTR1angiotensin II receptor, type 1Cartilage-2.370.000
184IL21Rinterleukin 21 receptorCartilage+2.370.000
185IFRD1interferon-related developmental regulator 1Cartilage-2.370.001
186ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Cartilage-2.370.000
187SCDstearoyl-CoA desaturase (delta-9-desaturase)Cartilage-2.370.027
188FKBP11FK506 binding protein 11, 19 kDaCartilage+2.360.000
189SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1Blood+2.360.000
190CALML4calmodulin-like 4Cartilage+2.360.000
191EDNRBendothelin receptor type BCartilage-2.350.000
192FYBFYN binding proteinCartilage+2.350.001
193CD247CD247 moleculeCartilage+2.350.000
194SLC2A6solute carrier family 2 (facilitated glucose transporter), member 6Cartilage+2.350.010
195TSKUtsukushi, small leucine rich proteoglycanCartilage-2.350.000
196TBX3T-box 3Cartilage-2.350.013
197IL7Rinterleukin 7 receptorCartilage+2.340.000
198CXCL10chemokine (C-X-C motif) ligand 10Cartilage+2.340.000
199HLA-DRAmajor histocompatibility complex, class II, DR alphaCartilage+2.330.000
200CD36CD36 molecule (thrombospondin receptor)Blood+2.330.000
201CA2carbonic anhydrase IICartilage+2.330.005
202C1orf21chromosome 1 open reading frame 21Cartilage-2.330.004
203TRDT cell receptor delta locusCartilage+2.320.002
204MSX2msh homeobox 2Cartilage+2.310.003
205KLRB1killer cell lectin-like receptor subfamily B, member 1Cartilage+2.310.001
206ITGB7integrin, beta 7Cartilage+2.310.002
207RUNX1-IT1RUNX1 intronic transcript 1 (non-protein coding)Cartilage+2.310.000
208COL1A2collagen, type I, alpha 2Cartilage+2.310.000
209ALOX5arachidonate 5-lipoxygenaseCartilage+2.300.000
210SLC6A3solute carrier family 6 (neurotransmitter transporter), member 3Cartilage-2.300.022
211ELL2elongation factor, RNA polymerase II, 2Cartilage-2.300.016
212IGLV6-57immunoglobulin lambda variable 6-57Cartilage+2.300.001
213SOD2superoxide dismutase 2, mitochondrialCartilage-2.290.000
214RTN1reticulon 1Cartilage+2.280.006
215NREPneuronal regeneration related proteinCartilage+2.280.000
216QPCTglutaminyl-peptide cyclotransferaseCartilage+2.280.021
217TPD52tumor protein D52Cartilage+2.280.000
218SELPLGselectin P ligandCartilage+2.270.004
219CD6CD6 moleculeCartilage+2.260.002
220RSAD2radical S-adenosyl methionine domain containing 2Blood+2.250.001
221SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Cartilage-2.250.002
222OLFM1olfactomedin 1Cartilage-2.250.002
223JUNBjun B proto-oncogeneCartilage-2.250.000
224PAX5paired box 5Cartilage+2.230.009
225AKR1C1aldo-keto reductase family 1, member C1Cartilage-2.230.007
226FOSFBJ murine osteosarcoma viral oncogene homologCartilage-2.220.010
227PIGAphosphatidylinositol glycan anchor biosynthesis, class ACartilage-2.220.000
228CD72CD72 moleculeCartilage+2.220.005
229FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)Cartilage-2.220.006
230CDO1cysteine dioxygenase type 1Cartilage-2.220.003
231XCL1chemokine (C motif) ligand 1Cartilage+2.210.017
232BTN3A2butyrophilin, subfamily 3, member A2Cartilage+2.210.006
233FAIM3Fas apoptotic inhibitory molecule 3Cartilage+2.210.015
234EREGepiregulinCartilage-2.210.004
235TPPP3tubulin polymerization-promoting protein family member 3Cartilage+2.200.009
236SPRY2sprouty homolog 2 (Drosophila)Cartilage-2.200.000
237GRAMD3GRAM domain containing 3Cartilage-2.200.020
238HLA-DMAmajor histocompatibility complex, class II, DM alphaCartilage+2.200.000
239COL5A1collagen, type V, alpha 1Cartilage+2.190.001
240OAS12'-5'-oligoadenylate synthetase 1, 40/46kDaBlood+2.190.000
241CYBBcytochrome b-245, beta polypeptideCartilage+2.190.000
242MRPL35mitochondrial ribosomal protein L35Cartilage+2.190.028
243JAK2Janus kinase 2Cartilage+2.190.009
244ZFP36ZFP36 ring finger proteinCartilage-2.190.000
245IFI27interferon, alpha-inducible protein 27Blood+2.180.015
246GBP1guanylate binding protein 1, interferon-inducibleCartilage+2.180.001
247TRIM33tripartite motif containing 33Cartilage+2.180.013
248LIPElipase, hormone-sensitiveCartilage-2.180.007
249FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Cartilage+2.180.001
250MEG3maternally expressed 3 (non-protein coding)Cartilage-2.170.017
251CX3CL1chemokine (C-X3-C motif) ligand 1Cartilage-2.170.002
252PNOCprepronociceptinCartilage+2.170.005
253SEMA3Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3ECartilage-2.160.042
254CRY2cryptochrome circadian clock 2Cartilage-2.160.010
255NOL3nucleolar protein 3 (apoptosis repressor with CARD domain)Cartilage-2.150.041
256SCN9Asodium channel, voltage-gated, type IX, alpha subunitCartilage+2.150.008
257DENND1BDENN/MADD domain containing 1BCartilage+2.150.005
258CSF1Rcolony stimulating factor 1 receptorCartilage+2.140.000
259NASPnuclear autoantigenic sperm protein (histone-binding)Blood+2.140.000
260TACC3transforming, acidic coiled-coil containing protein 3Cartilage+2.140.002
261CDK1cyclin-dependent kinase 1Cartilage+2.130.002
262ST14suppression of tumorigenicity 14 (colon carcinoma)Cartilage+2.130.011
263MKI67marker of proliferation Ki-67Cartilage+2.130.002
264BCL6B-cell CLL/lymphoma 6Cartilage-2.130.000
265BTN2A2butyrophilin, subfamily 2, member A2Cartilage+2.130.006
266CYTIPcytohesin 1 interacting proteinCartilage+2.130.001
267CLEC4AC-type lectin domain family 4, member ACartilage+2.120.007
268CRLF1cytokine receptor-like factor 1Cartilage-2.120.014
269CD79ACD79a molecule, immunoglobulin-associated alphaCartilage+2.120.000
270NUSAP1nucleolar and spindle associated protein 1Cartilage+2.120.001
271ACACBacetyl-CoA carboxylase betaCartilage-2.110.002
272FLJ10038uncharacterized protein FLJ10038Cartilage-2.100.023
273HLA-DPB1major histocompatibility complex, class II, DP beta 1Cartilage+2.100.000
274PRG2proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)Cartilage-2.100.012
275WNT11wingless-type MMTV integration site family, member 11Cartilage-2.100.009
276KCNK3potassium channel, subfamily K, member 3Cartilage-2.100.001
277CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)Cartilage+2.090.018
278IFI30interferon, gamma-inducible protein 30Cartilage+2.090.003
279BLNKB-cell linkerCartilage+2.080.000
280PDLIM7PDZ and LIM domain 7 (enigma)Cartilage+2.080.025
281PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2Cartilage-2.080.005
282TNFRSF25tumor necrosis factor receptor superfamily, member 25Cartilage+2.080.005
283MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Blood+2.080.000
284CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Cartilage-2.080.000
285ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3Cartilage+2.080.006
286AREGamphiregulinCartilage-2.080.045
287ITGAXintegrin, alpha X (complement component 3 receptor 4 subunit)Cartilage+2.080.017
288ZC3H12Azinc finger CCCH-type containing 12ACartilage-2.080.022
289BOD1L1biorientation of chromosomes in cell division 1-like 1Blood+2.070.000
290ARG2arginase 2Cartilage-2.070.012
291LTBP4latent transforming growth factor beta binding protein 4Cartilage-2.060.012
292TMEM100transmembrane protein 100Cartilage-2.060.041
293VEGFAvascular endothelial growth factor ACartilage-2.060.013
294XAF1XIAP associated factor 1Blood+2.050.000
295KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1Cartilage-2.050.028
296LOC399491GPS, PLAT and transmembrane domain-containing proteinCartilage-2.050.011
297IER2immediate early response 2Cartilage-2.040.001
298SPTBN1spectrin, beta, non-erythrocytic 1Cartilage-2.030.048
299CDH19cadherin 19, type 2Cartilage-2.030.003
300MAPK8mitogen-activated protein kinase 8Cartilage-2.020.011
301SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1Cartilage-2.020.002
302CCNL1cyclin L1Cartilage-2.020.001
303GGT5gamma-glutamyltransferase 5Cartilage-2.020.022
304ITGA7integrin, alpha 7Cartilage-2.010.037
305GABARAPL1GABA(A) receptor-associated protein like 1Cartilage-2.000.000
306SLCO4A1solute carrier organic anion transporter family, member 4A1Cartilage-2.000.015
307SMAD3SMAD family member 3Cartilage-1.960.015
308S100A8S100 calcium binding protein A8Brain+1.960.043
309ZFAND5zinc finger, AN1-type domain 5Cartilage-1.960.004
310TFtransferrinCartilage-1.960.032
311NLGN1neuroligin 1Cartilage-1.950.009
312PLIN2perilipin 2Cartilage-1.930.012
313IFI44Linterferon-induced protein 44-likeBlood+1.910.009
314GRB10growth factor receptor-bound protein 10Cartilage-1.910.030
315AMFRautocrine motility factor receptor, E3 ubiquitin protein ligaseBlood+1.910.002
316CXCL2chemokine (C-X-C motif) ligand 2Cartilage-1.910.046
317CPceruloplasmin (ferroxidase)Cartilage-1.900.033
318ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Cartilage-1.900.012
319SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Cartilage-1.900.044
320KLHL21kelch-like family member 21Cartilage-1.890.037
321EIF4A1eukaryotic translation initiation factor 4A1Cartilage-1.890.001
322DDIT4DNA-damage-inducible transcript 4Cartilage-1.890.021
323NEUROG3neurogenin 3Cartilage-1.890.034
324IL1R1interleukin 1 receptor, type ICartilage-1.880.038
325CLDN5claudin 5Cartilage-1.880.047
326SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1Blood+1.870.003
327ABLIM1actin binding LIM protein 1Cartilage-1.870.001
328SASH1SAM and SH3 domain containing 1Cartilage-1.870.003
329MAP1Bmicrotubule-associated protein 1BCartilage-1.860.014
330WASLWiskott-Aldrich syndrome-likeCartilage-1.860.031
331GPHNgephyrinCartilage-1.850.041
332WASF3WAS protein family, member 3Cartilage-1.850.000
333SOX9SRY (sex determining region Y)-box 9Cartilage-1.850.004
334GPC5glypican 5Cartilage-1.840.028
335PID1phosphotyrosine interaction domain containing 1Cartilage-1.840.015
336IFI44interferon-induced protein 44Blood+1.840.012
337SDC4syndecan 4Cartilage-1.840.009
338SFRP1secreted frizzled-related protein 1Cartilage-1.830.000
339MAB21L2mab-21-like 2 (C. elegans)Cartilage-1.830.020
340ZNF395zinc finger protein 395Cartilage-1.830.002
341BAG3BCL2-associated athanogene 3Cartilage-1.820.003
342EGFRepidermal growth factor receptorCartilage-1.820.002
343MT1Xmetallothionein 1XCartilage-1.810.003
344YBX3Y box binding protein 3Cartilage-1.810.002
345PDE4Bphosphodiesterase 4B, cAMP-specificCartilage-1.810.024
346IQGAP1IQ motif containing GTPase activating protein 1Blood+1.800.000
347PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaCartilage-1.800.024
348PLS1plastin 1Cartilage-1.800.024
349AKAP1A kinase (PRKA) anchor protein 1Cartilage-1.780.002
350FSTL3follistatin-like 3 (secreted glycoprotein)Cartilage-1.780.020
351P2RY2purinergic receptor P2Y, G-protein coupled, 2Cartilage-1.770.023
352GSNgelsolinCartilage-1.770.041
353PNPLA2patatin-like phospholipase domain containing 2Cartilage-1.760.035
354SLC16A7solute carrier family 16 (monocarboxylate transporter), member 7Cartilage-1.750.013
355RND3Rho family GTPase 3Cartilage-1.750.000
356PER2period circadian clock 2Cartilage-1.740.049
357C10orf118chromosome 10 open reading frame 118Blood+1.730.001
358NAV2neuron navigator 2Cartilage-1.720.011
359PRRC2Cproline-rich coiled-coil 2CBlood+1.710.000
360IFIT2interferon-induced protein with tetratricopeptide repeats 2Blood+1.710.001
361MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FBrain+1.700.047
362CDC27cell division cycle 27Blood+1.700.000
363ZNF254zinc finger protein 254Blood+1.620.000
364RAB8BRAB8B, member RAS oncogene familyBlood+1.600.009
365FCARFc fragment of IgA, receptor forBlood+1.580.004
366LLGL1lethal giant larvae homolog 1 (Drosophila)Blood+1.570.003
367STAT2signal transducer and activator of transcription 2, 113kDaBlood+1.550.000
368IFIT1interferon-induced protein with tetratricopeptide repeats 1Blood+1.550.046
369HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5Blood+1.540.029
370MARCKSmyristoylated alanine-rich protein kinase C substrateBlood+1.540.000
371ANKRD36ankyrin repeat domain 36Blood+1.530.001
372ACTR2ARP2 actin-related protein 2 homolog (yeast)Blood+1.520.002
373ZC3HAV1zinc finger CCCH-type, antiviral 1Blood+1.520.000
374IFIT5interferon-induced protein with tetratricopeptide repeats 5Blood+1.510.007
375THAP6THAP domain containing 6Blood+1.490.019
376ZBTB18zinc finger and BTB domain containing 18Blood+1.490.004
377IFIT3interferon-induced protein with tetratricopeptide repeats 3Blood+1.480.034
378CYBBcytochrome b-245, beta polypeptideBlood+1.460.002
379ADAM17ADAM metallopeptidase domain 17Blood+1.450.003
380NFAT5nuclear factor of activated T-cells 5, tonicity-responsiveBlood+1.420.004
381STYXserine/threonine/tyrosine interacting proteinBlood+1.410.001
382SARSseryl-tRNA synthetaseBlood+1.400.003
383PAPPApregnancy-associated plasma protein A, pappalysin 1Blood+1.400.000
384PCNPPEST proteolytic signal containing nuclear proteinBlood+1.380.030
385CAPZA2capping protein (actin filament) muscle Z-line, alpha 2Blood+1.360.006
386ATP11BATPase, class VI, type 11BBlood+1.360.013
387THRAP3thyroid hormone receptor associated protein 3Blood+1.360.013
388MAP3K2mitogen-activated protein kinase kinase kinase 2Blood+1.340.022
389GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide OBlood+1.330.029
390H19H19, imprinted maternally expressed transcript (non-protein coding)Blood+1.330.000
391PTP4A1protein tyrosine phosphatase type IVA, member 1Blood+1.300.017
392MS4A6Amembrane-spanning 4-domains, subfamily A, member 6ABlood+1.300.006
393CLCN3chloride channel, voltage-sensitive 3Blood+1.280.012
394DUSP8dual specificity phosphatase 8Blood+1.270.040
395KDM3Blysine (K)-specific demethylase 3BBlood+1.260.011
396TMED2transmembrane emp24 domain trafficking protein 2Blood+1.250.041
397GRIK1glutamate receptor, ionotropic, kainate 1Blood+1.240.004
398ESCO1establishment of sister chromatid cohesion N-acetyltransferase 1Blood+1.230.040
399SP1Sp1 transcription factorBlood+1.200.048
400RFFLring finger and FYVE-like domain containing E3 ubiquitin protein ligaseBlood+1.200.013


Search GEO for disease gene expression data for Rheumatoid Arthritis.

Pathways for genes affiliated with Rheumatoid Arthritis

About this section

Pathways related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.5IL1A, IL6, IL10, HLA-DRB1, CIITA
210.5IL1A, IL6, CIITA, HLA-DRB1, IL10
3
Show member pathways
10.5HLA-DRB1, IL6, IL1A, IL10, IL17A, STAT4
410.5PTPN22, CIITA, IL10
5
Show member pathways
10.5IL6, IL10, CCL2, PTPN22, IL1A
610.5IL6, HLA-DRB1, IL10, IL1A
7
Show member pathways
10.5HLA-DRB1, CIITA, IL6, IL1A
8
Show member pathways
10.5IL1A, IL6, CCL2, CIITA, HLA-DRB1
910.5IL1A, IL6, IL10
1010.5IL1A, IL10, IL6
1110.5IL1A, IL6, IL10
1210.5IL6, IL10, IL1A
1310.5CCL2, IL6, IL10
14
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
10.5IL17A, IL6, IL10, IL1A
15
Show member pathways
10.5STAT4, CCL2, IL10, IL6, IL1A
16
Show member pathways
10.5IL6, CCL2, IL10, STAT4, IL1A
1710.5IL1A, IL6, HLA-DRB1
18
Show member pathways
Type III interferon signaling38
10.5IL6, STAT4, IL10
19
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.5CCL2, STAT4, IL17A, IL10, IL6
20
Show member pathways
IL27-mediated signaling events38
10.5IL6, IL10, STAT4, IL17A
21
Show member pathways
10.5CCL2, IL1A, IL10, IL17RA, IL17A, IL6
22
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
10.5CCL2, IL10, IL6, STAT4, CTSK
2310.5IL6, CTSK, HLA-DRB1, IL1A, IL17A, CCL2
2410.5CCL2, IL1A, IL6
25
Show member pathways
thioredoxin pathway38
10.5SAA1, CCL2, IL6
26
Show member pathways
10.5IL17A, IL17RA, IL6
27
Show member pathways
10.5IL6, IL17RA, IL17A
28
Show member pathways
10.5STAT4, IL17A, IL6, IL17RA

Compounds for genes affiliated with Rheumatoid Arthritis

About this section

Compounds related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.9IL1A, SAA1, IL6, IL10, CCL2, IL17A
2nitric oxide45 26 1312.9CIITA, SERPINH1, CCL2, IL17A, IL10, IL6
3rantes4510.9IL17A, CIITA, IL6, IL1A, IL10, IL17RA
4groalpha4510.9IL10, IL6, IL1A, CCL2, IL17A
5simvastatin45 51 61 30 26 1315.9CIITA, SAA1, IL1A, CCL2, IL10, IL6
6dexamethasone45 51 30 1313.9IL6, SAA1, STAT4, CCL2, IL17A, IL10
7il-124510.9IL6, CCL2, STAT4, IL10
8polyinosinic-polycytidylic acid4510.9IL6, IL10, IL1A, CIITA
9polymyxin b4510.9IL1A, IL6, IL10, CCL2
10gm-csf45 3011.9IL1A, IL6, IL10, CCL2
11arginine4510.9PADI4, SLC22A4, SAA1, IL1A, PTPN22, HLA-DRB1
12cyclosporin a45 30 6112.9IL1A, IL6, IL10, IL17A, SERPINH1, CIITA
13il 104510.9IL6, IL10, IL1A, CCL2
14tyrosine4510.9HLA-DRB1, CIITA, SERPINH1, STAT4, IL17A, CD244
15ccl345 3011.9CCL2, IL10, IL6, IL1A
16pge24510.9IL1A, IL6, IL10, IL17A, CIITA, CCL2
17allergens4510.9IL10, STAT4, HLA-DRB1, CIITA
18tenidap45 3011.9IL6, IL1A, SAA1
19mcp 14510.9CCL2, IL6, IL10
20glatiramer acetate45 1311.9IL10, CIITA, HLA-DRB1
21toxin-14510.9IL10, CCL2, CIITA
22mip 1alpha4510.9CCL2, IL10, IL6
23mdms4510.9CCL2, CIITA, IL10
24aprotinin45 1311.9CTSK, IL1A, IL6, IL10
25corticosterone45 61 2612.9IL1A, SLC22A4, CCL2, IL10
26sb 20358045 6111.9IL6, IL17A, IL1A, CCL2, IL10
27vitamin d4510.9IL6, SLC11A1, IL1A, CCL2, IL10
28imiquimod45 61 30 1313.8IL1A, IL6, IL10
29ly2940024510.8CD244, IL6, IL10, IL17A, CCL2
30actinomycin d4510.8CCL2, IL17A, IL6, IL1A, CIITA
31lipoteichoic acid4510.8IL6, IL10, CCL2
32vegf4510.8CCL2, SERPINH1, IL1A, IL6, IL10, IL17A
338-isoprostane4510.8CCL2, IL10, IL6
34lipid4510.8CCL2, IL17A, CIITA, IL6, SLC22A4, CD244
35etanercept45 51 1312.8IL17A, IL10, IL6
36curcumin4510.8IL1A, IL6, IL17A, CCL2
37thymidine45 2611.8CIITA, IL17A, IL10, IL6, IL1A
38muramyl tripeptide4510.8CCL2, IL1A
39aspartate4510.7SLC11A1, IL1A, IL10, CCL2, CTSK
40methotrexate51 45 1312.7IL17A, HLA-DRB1, IL10, IL6
41iron sucrose4510.7CCL2, IL6
42tarc4510.7IL1A, IL10, CCL2
43infliximab45 51 1312.7IL17A, IL10, IL6
44peptidoglycan45 3011.6IL10, IL6, CIITA
45ivig4510.6IL6, IL10, IL1A
46pentoxifylline45 1311.6IL1A, IL6, IL10
47cycloheximide4510.5CIITA, IL1A, IL10, IL6, CCL2
48fluvastatin45 51 30 1313.5IL6, CCL2, IL1A
49cdp5714510.4IL6, IL10
50ifn-alpha4510.2IL17A, IL10, IL6

GO Terms for genes affiliated with Rheumatoid Arthritis

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Cellular components related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:000557610.5CTSK, IL1A, IL6, IL17RA, CCL2, SAA1
2extracellular spaceGO:000561510.4CTSK, IL1A, IL6, IL10, IL17A, CCL2
3external side of plasma membraneGO:000989710.2HLA-DRB1, IL17A, IL6, CD244

Biological processes related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:000695410.9CIITA, CCL2, IL17A, IL10, IL6, IL1A
2cytokine-mediated signaling pathwayGO:001922110.9IL1A, HLA-DRB1, CIITA, STAT4, CCL2, IL17RA
3positive regulation of transcription from RNA polymerase II promoterGO:004594410.9CIITA, STAT4, IL17A, IL10, IL6, IL1A
4positive regulation of cytokine secretionGO:005071510.8SAA1, IL10, IL1A
5response to antibioticGO:004667710.8IL6, CCL2, CIITA
6regulation of vascular endothelial growth factor productionGO:001057410.8IL6, CCL2
7negative regulation of collagen biosynthetic processGO:003296610.8IL6, CIITA
8fibroblast activationGO:007253710.8IL17A, IL17RA
9humoral immune responseGO:000695910.8IL6, CCL2, BST1
10positive regulation of MHC class II biosynthetic processGO:004534810.8IL10, CIITA
11positive regulation of interleukin-23 productionGO:003274710.8IL17A, IL17RA
12cellular response to lipopolysaccharideGO:007122210.8CCL2, IL10, NFKBIL1
13lymphocyte chemotaxisGO:004824710.8CCL2, SAA1
14positive regulation of cytokine production involved in inflammatory responseGO:0190001710.8IL17RA, IL17A
15response to glucocorticoidGO:005138410.7IL6, IL10, CCL2
16immune responseGO:000695510.7IL1A, IL17A, CIITA, HLA-DRB1
17agingGO:000756810.7CIITA, CCL2, IL6
18macrophage chemotaxisGO:004824610.7CCL2, SAA1
19defense response to protozoanGO:004283210.7SLC11A1, IL6
20monocyte chemotaxisGO:000254810.6CCL2, IL6
21response to bacteriumGO:000961710.6SLC11A1, CCL2
22response to interferon-gammaGO:003434110.6CIITA, SLC11A1
23defense response to Gram-negative bacteriumGO:005082910.5SLC11A1, IL6
24JAK-STAT cascadeGO:000725910.5CCL2, STAT4
25response to amino acidGO:004320010.4IL6, CCL2
26negative regulation of interferon-gamma productionGO:003268910.2IL10, HLA-DRB1

Molecular functions related to Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.5IL1A, IL6, IL10, IL17A

Products for genes affiliated with Rheumatoid Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Rheumatoid Arthritis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet