MCID: RHM011
MIFTS: 87

Rheumatoid Arthritis

Categories: Genetic diseases, Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis

MalaCards integrated aliases for Rheumatoid Arthritis:

Name: Rheumatoid Arthritis 54 38 12 25 71 29 52 41 3 3 3 14 69
Ra 25 71 3
Rheumatoid Arthritis, Progression of 54 13
Arthritis, Rheumatoid 25 42
Arthritis or Polyarthritis, Rheumatic 12
Atrophic Arthritis 12

Characteristics:

OMIM:

54
Inheritance:
unproved inheritance


Classifications:



External Ids:

OMIM 54 180300
Disease Ontology 12 DOID:7148
ICD9CM 35 714.0
MeSH 42 D001172
NCIt 47 C27206 C2884
MedGen 40 C0003873
UMLS 69 C0003873

Summaries for Rheumatoid Arthritis

MedlinePlus : 41 rheumatoid arthritis (ra) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. it can affect any joint but is common in the wrist and fingers. more women than men get rheumatoid arthritis. it often starts in middle age and is most common in older people. you might have the disease for only a short time, or symptoms might come and go. the severe form can last a lifetime. rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. ra can affect body parts besides joints, such as your eyes, mouth and lungs. ra is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. no one knows what causes rheumatoid arthritis. genes, environment, and hormones might contribute. treatments include medicine, lifestyle changes, and surgery. these can slow or stop joint damage and reduce pain and swelling. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Rheumatoid Arthritis, also known as ra, is related to systemic lupus erythematosus and lung disease, and has symptoms including vasculitis, abnormality of the immune system and abnormality of the nervous system. An important gene associated with Rheumatoid Arthritis is IL10 (Interleukin 10), and among its related pathways/superpathways are Rheumatoid arthritis and Innate Immune System. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, bone and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

UniProtKB/Swiss-Prot : 71 Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Genetics Home Reference : 25 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

OMIM : 54
Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. (180300)

Disease Ontology : 12 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

Wikipedia : 72 Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically... more...

Related Diseases for Rheumatoid Arthritis

Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 862)
id Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 33.1 CCL2 FCRL3 HLA-DRB1 IL10 IL17A IL6
2 lung disease 32.7 IL17A MMP3 TNF TNFRSF1B
3 atherosclerosis 32.6 CCL2 CSF1 FCRL3 HLA-DRB1 IL10 IL17A
4 lymphoma 32.5 IL10 IL17A IL1B IL6 TNF
5 primary biliary cirrhosis 32.1 IL10 IL1A IL6 TNF TNFRSF1B
6 asthma 32.1 HLA-DRB1 IL10 IL17A IL1A IL1B IL6
7 cryptococcosis 32.0 HLA-DRB1 IL10 IL17A TNF TNFRSF1B
8 ulcerative colitis 32.0 IL10 IL6 TNF
9 neuropathy 31.9 IL1A TNF TNFSF11
10 myocardial infarction 31.9 CCL2 CIITA IL10 IL1B IL6 MMP3
11 scabies 31.8 CCL2 IL10 IL1B IL6 TNF
12 alopecia 31.8 CCL2 IL10 IL6 TNF
13 autoimmune hepatitis 31.7 CCL2 IL1B MMP3 TNF
14 pulmonary embolism 31.6 CCL2 IL10 IL1B IL6 TNF
15 acute interstitial pneumonia 31.6 IL10 IL6 TNF
16 hemophagocytic lymphohistiocytosis 31.5 IL10 IL6 TNF
17 calcinosis 31.4 CCL2 IL6 TNF
18 pyelonephritis 31.4 IL10 IL1B TNF
19 choroiditis 31.4 CCL2 IL10 IL1B IL6 TNF
20 kaposi sarcoma 31.4 HLA-DRB1 IL1A IL1B IL6 PTPN22 TNF
21 churg-strauss syndrome 31.4 IL10 IL17A IL1B TNF
22 hypervitaminosis d 31.3 IL10 IL1B IL6 TNF
23 tracheal stenosis 31.3 IL17A IL6 TNF
24 acute pancreatitis 31.3 CCL2 IL1B IL6 MMP3
25 impotence 31.3 CSF1 IL1A TNFSF11
26 c1 inhibitor deficiency 31.3 IL17A IL6 TNF
27 cortical blindness 30.6 CSF1 TNFSF11
28 rheumatoid arthritis, systemic juvenile 12.5
29 ras-associated autoimmune leukoproliferative disorder 12.3
30 felty syndrome 12.1
31 arthritis 11.8
32 rheumatoid lung disease 11.5
33 central nervous system leiomyosarcoma 11.5 HLA-DRB1 IL17A IL1B IL6 TNF
34 ostertagiasis 11.5 CCL2 IL10 IL17A IL1B IL6 TNF
35 pseudohypoparathyroidism 11.5 FCRL3 HLA-DRB1 IL10 IL17A IL1B IL6
36 ragweed sensitivity 11.5 CCL2 IL10 IL17A IL1A IL1B IL6
37 acute chest syndrome 11.5 CCL2 IL10 IL17A IL1B IL6 TNF
38 optic nerve hypoplasia 11.5 CCL2 IL10 IL17A IL1B IL6 TNF
39 disease of mental health 11.5 HLA-DRB1 IL10 IL17A IL6 TNF
40 iida kannari syndrome 11.5 HLA-DRB1 IL10 IL1A IL1B IL6 TNF
41 adult-onset still's disease 11.5
42 cerebellar disease 11.5 IL10 IL17A IL1A IL1B IL6 TNF
43 antigen-peptide-transporter 2 deficiency 11.5 CCL2 IL6 PTPN22 TNF
44 ovarian mucinous adenofibroma 11.5 CCL2 IL10 IL1B IL6 TNF
45 high pressure neurological syndrome 11.5 CCL2 IL10 IL1B IL6 TNF
46 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 11.5 CCL2 CSF1 IL1A IL1B IL6 TNF
47 atrophy of prostate 11.5 CCL2 IL10 IL1B IL6 TNF
48 histiocytic and dendritic cell cancer 11.5 CCL2 IL10 IL17A IL1A IL1B IL6
49 granulomatous orchitis 11.5 CCL2 IL10 IL1A IL1B IL6 TNF
50 epstein-barr virus hepatitis 11.5 HLA-DRB1 IL1A IL6 TNF

Comorbidity relations with Rheumatoid Arthritis via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Bronchiectasis Bronchitis
Chronic Rheumatic Pericarditis Decubitus Ulcer
Deficiency Anemia Esophagitis
Felty Syndrome Heart Disease
Hypersensitivity Vasculitis Hypertension, Essential
Hypothyroidism Idiopathic Interstitial Pneumonia
Iron Deficiency Anemia Mononeuropathy of the Median Nerve, Mild
Neutropenia Olecranon Bursitis
Oral Candidiasis Osteoarthritis
Osteoporosis Perforated Corneal Ulcer
Pituitary Adenoma, Acth-Secreting Postinflammatory Pulmonary Fibrosis
Premature Ovarian Failure 7 Primary Immunodeficiency Disease
Protein-Energy Malnutrition Rheumatoid Lung Disease
Scleritis Sjogren's Syndrome
Spondyloarthropathy 1 Systemic Lupus Erythematosus
Temporal Arteritis

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to Rheumatoid Arthritis

Symptoms & Phenotypes for Rheumatoid Arthritis

Symptoms via clinical synopsis from OMIM:

54

Joints:
rheumatoid arthritis

Limbs:
rheumatoid nodules

Vascular:
rheumatoid vasculitis

Neuro:
rheumatoid vasculitic mononeuritis

Immunology:
hla-drb1 association

Pulm:
rheumatoid lung disease

Heme:
felty syndrome


Clinical features from OMIM:

180300

Human phenotypes related to Rheumatoid Arthritis:

32 (show all 6)
id Description HPO Frequency HPO Source Accession
1 vasculitis 32 HP:0002633
2 rheumatoid arthritis 32 HP:0001370
3 abnormality of the immune system 32 HP:0002715
4 abnormality of the nervous system 32 HP:0000707
5 abnormality of blood and blood-forming tissues 32 HP:0001871
6 abnormality of the respiratory system 32 HP:0002086

UMLS symptoms related to Rheumatoid Arthritis:


back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Rheumatoid Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 CD244 CIITA CSF1 IL10 IL17A IL1A
2 homeostasis/metabolism MP:0005376 10.2 TNF TNFRSF1B TNFSF11 CIITA CSF1 IL10
3 immune system MP:0005387 10.19 TNFRSF1B TNFSF11 CCL2 CD244 CIITA CSF1
4 endocrine/exocrine gland MP:0005379 10.1 CIITA CSF1 IL10 IL17A IL6 PTPN22
5 neoplasm MP:0002006 9.7 IL10 IL1A IL1B IL6 TNF TNFRSF1B
6 respiratory system MP:0005388 9.56 PTPN22 TNF TNFRSF1B TNFSF11 CSF1 IL10
7 skeleton MP:0005390 9.36 CIITA CSF1 IL10 IL17A IL1B IL6

Drugs & Therapeutics for Rheumatoid Arthritis

Drugs for Rheumatoid Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 560)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
2
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
4
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
5
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
6
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
7
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2 16590-41-3 5360515
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
11
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5353980 5359476
12
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
13
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
14
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
15
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
16
Menthol Approved Phase 4,Phase 3,Early Phase 1 2216-51-5 16666
17
Dimethyl fumarate Approved, Investigational Phase 4,Phase 2 624-49-7 5271565 637568
18
Zinc Approved Phase 4 7440-66-6 32051 23994
19
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
20
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
21
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
22
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
23
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
24
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
25
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
26
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
27
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
28
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
29
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
30
chloroquine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54-05-7 2719
31
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
32
Ethanol Approved Phase 4,Phase 2 64-17-5 702
33
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
34
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
35
Norepinephrine Approved Phase 4 51-41-2 439260
36
Milnacipran Approved Phase 4 92623-85-3 65833
37
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
38
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
39 Racepinephrine Approved Phase 4
40
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
41
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
42
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Phase 2 378-44-9 9782
43
Diphenhydramine Approved Phase 4 58-73-1, 147-24-0 3100
44
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
45
Promethazine Approved Phase 4 60-87-7 4927
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
47
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
48
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
49
Denosumab Approved Phase 4,Phase 2,Phase 1 615258-40-7
50
Tramadol Approved, Investigational Phase 4 27203-92-5 33741

Interventional clinical trials:

(show top 50) (show all 2336)

id Name Status NCT ID Phase Drugs
1 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
4 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
5 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
6 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
7 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
8 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
9 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
10 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
11 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
12 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
13 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
14 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
15 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
16 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
17 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
18 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
19 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
20 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
21 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
22 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
23 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
24 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
25 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
26 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
27 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
28 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
29 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
30 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
31 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
32 Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate Therapy Completed NCT00244556 Phase 4 Methotrexate plus ENBREL or ENBREL alone
33 Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA) Completed NCT01382160 Phase 4
34 Relaxation Response Training for the Treatment of Rheumatoid Arthritis Completed NCT00056667 Phase 4
35 Treatment of Rheumatoid Arthritis With Roxithromycin Completed NCT00439062 Phase 4 Roxithromycin
36 Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects Completed NCT00252668 Phase 4 Etanercept;Methotrexate
37 Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis Completed NCT01225991 Phase 4 Milnacipran
38 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
39 A Study of Iguratimod in Patients With Active Rheumatoid Arthritis Completed NCT01554917 Phase 4 Iguratimod
40 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
41 Efficacy of HUMIRA in Subjects With Active Rheumatoid Arthritis Completed NCT00234897 Phase 4 adalimumab
42 Prospective Study on Intensive Early Rheumatoid Arthritis Treatment Completed NCT00480272 Phase 4 adalimumab, plus prednisone;adalimumab plus placebo
43 The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study. Completed NCT01270087 Phase 4 Adalimumab
44 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
45 Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis Completed NCT01404429 Phase 4 Methotrexate
46 Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders Completed NCT00132418 Phase 4 Enbrel;Placebo
47 Study Evaluating Etanercept in Patients With Rheumatoid Arthritis Who Completed Trial 0881A1-301-EU in Spain Completed NCT00195364 Phase 4 Etanercept
48 Evaluation of EULAR-RAID Score in Rheumatoid Arthritis Patients Completed NCT00768053 Phase 4 Etanercept
49 A Non-Interventional Study Evaluating Rheumatoid Arthritis Participants Treated With Tocilizumab (RoActemra/Actemra) Completed NCT01671059 Phase 4
50 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection

Search NIH Clinical Center for Rheumatoid Arthritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: arthritis, rheumatoid

Genetic Tests for Rheumatoid Arthritis

Genetic tests related to Rheumatoid Arthritis:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis 29

Anatomical Context for Rheumatoid Arthritis

MalaCards organs/tissues related to Rheumatoid Arthritis:

39
Bone, T Cells, Lung, Endothelial, B Cells, Monocytes, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
id Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease

Publications for Rheumatoid Arthritis

Articles related to Rheumatoid Arthritis:

(show top 50) (show all 8422)
id Title Authors Year
1
Chest Pain Due to Pericardial Effusion as Initial Presenting Feature of Rheumatoid Arthritis: Case Report and Review of the Literature. ( 28868101 )
2017
2
Proprotein convertase subtilisin/kexin type 6 promotes inA vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblasta89like cells from rheumatoid arthritis via nucleara89I_B, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways. ( 28944919 )
2017
3
Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. ( 28885321 )
2017
4
TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin. ( 28271077 )
2017
5
Cervical spine involvement risk factors in rheumatoid arthritis: a meta-analysis. ( 28524646 )
2017
6
Laryngeal stridor in rheumatoid arthritis. ( 28947548 )
2017
7
Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients. ( 28087671 )
2017
8
TNFR1 and TNFR2 differentially mediate TNF-I+-induced inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes. ( 28150360 )
2017
9
YKL-40 and cytokines - a New Diagnostic Constellation in Rheumatoid Arthritis? ( 28384116 )
2017
10
Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-I+ and hydroxychloroquine treatment for rheumatoid arthritis. ( 28331899 )
2017
11
Obinutuzumab is Effective in Chronic Lymphocytic Leukemia and Rheumatoid Arthritis After Rituximab Failure: A Case Report. ( 28487504 )
2017
12
Genetic association of aromatic hydrocarbon receptor and its repressor gene polymorphisms with risk of rheumatoid arthritis in Han Chinese populations. ( 28403070 )
2017
13
Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. ( 27457515 )
2017
14
Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis. ( 28083614 )
2017
15
Tailored Therapist-guided Internet-based Cognitive-behavioural Treatment for Psoriasis and Rheumatoid Arthritis: Two Case Reports. ( 28952654 )
2017
16
Level of agreement between three-dimensional volumetric ultrasound and real-time conventional ultrasound in the assessment of synovitis, tenosynovitis and erosions in rheumatoid arthritis patients. ( 27896420 )
2017
17
Tenosynovitis in rheumatoid arthritis patients on biologic treatment: involvement and sensitivity to change compared to joint inflammation. ( 28516887 )
2017
18
Single strain versus multi-strain probiotics supplementation against rheumatoid arthritis. ( 28950432 )
2017
19
The coexistence of SAPHO syndrome and rheumatoid arthritis: A case report. ( 28072711 )
2017
20
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. ( 28081709 )
2017
21
Nephrocalcinosis in a patient with rheumatoid arthritis and secondary SjAPgren's syndrome. ( 28359765 )
2017
22
Influence of obesity, age, and comorbidities on the multi-biomarker disease activity test in rheumatoid arthritis. ( 28947312 )
2017
23
Rheumatoid arthritis: New model linking periodontitis and RA. ( 28053334 )
2017
24
Primary Breast Lymphoma with cutaneous involvement in a patient with Rheumatoid Arthritis - a complication of infliximab therapy? ( 28375194 )
2017
25
Italian consensus Guidelines for the management of hepatitis B virus infections in patients with rheumatoid arthritis. ( 28529116 )
2017
26
Elevated Serum Levels of Interleukin-29 Are Associated with Disease Activity in Rheumatoid Arthritis Patients with Anti-Cyclic Citrullinated Peptide Antibodies. ( 28154345 )
2017
27
Impaired NK cell functionality and increased TNF-I+ production as biomarkers of chronic chikungunya arthritis and rheumatoid arthritis. ( 28213049 )
2017
28
The association between insulin-like growth factor 1 (IGF-1), IGF-binding proteins (IGFBPs), and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis. ( 27775453 )
2017
29
Association between use of disease-modifying antirheumatic drugs and diabetes in patients with ankylosing spondylitis, rheumatoid arthritis, or psoriasis/psoriatic arthritis: a nationwide, population-based cohort study of 84,989 patients. ( 28496328 )
2017
30
Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis. ( 28948174 )
2017
31
Lack of Association between STAT4 Single Nucleotide Polymorphisms and Iranian Juvenile Rheumatoid Arthritis Patients. ( 28524764 )
2017
32
Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis. ( 28526072 )
2017
33
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8(+) T Cytotoxic Lymphocytes and CD19(+) B Lymphocytes in Rheumatoid Arthritis Responding to TNF-I+ Inhibition. ( 28426141 )
2017
34
Power Doppler signal calibration in the finger joint between two models of ultrasound machine: a pilot study using a phantom and joints in patients with rheumatoid arthritis. ( 28084811 )
2017
35
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
36
Tear Fluid Protein Changes in Dry Eye Syndrome Associated with Rheumatoid Arthritis: A Proteomic Approach. ( 27789276 )
2017
37
Rheumatoid arthritis: Reducing the risk of herpes zoster. ( 28905860 )
2017
38
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? ( 28293454 )
2017
39
Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1I^ signaling in rheumatoid arthritis synovial fibroblasts. ( 28532672 )
2017
40
uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis. ( 28090093 )
2017
41
Prevalence and Clinical Characteristics of Rheumatoid Arthritis in an Inner City Population with Sickle Cell Disease. ( 28944097 )
2017
42
No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary SjAPgren's syndrome in a Chinese Han population. ( 28914367 )
2017
43
Tenosynovitis Evaluation Using Image Fusion and B-Flow - A Pilot Study on New Imaging Techniques in Rheumatoid Arthritis Patients. ( 28511227 )
2017
44
Low Hemoglobin Predicts Radiographic Damage Progression in Early Rheumatoid Arthritis - Secondary Analysis from a Phase III trial. ( 28950430 )
2017
45
Peritoneal tuberculosis in patients with rheumatoid arthritis undergoing adalimumab treatment. ( 28527603 )
2017
46
Increased risk of rheumatoid arthritis among mothers with children who carry DRB1 risk-associated alleles. ( 28391248 )
2017
47
Prevalence of Autonomic Neuropathy in Patients of Rheumatoid Arthritis and Its Correlation with Disease Severity. ( 28571182 )
2017
48
Bone Morphogenetic Protein 2 and Transforming Growth Factor I^1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts. ( 27865758 )
2017
49
Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis. ( 26189371 )
2017
50
Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. ( 28952205 )
2017