MCID: RHM021
MIFTS: 55

Rheumatoid Arthritis, Systemic Juvenile

Categories: Genetic diseases, Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Rheumatoid Arthritis, Systemic Juvenile

MalaCards integrated aliases for Rheumatoid Arthritis, Systemic Juvenile:

Name: Rheumatoid Arthritis, Systemic Juvenile 54 29 52 69
Juvenile Rheumatoid Arthritis 12 50 25 14 69
Juvenile Idiopathic Arthritis 12 50 25
Juvenile Arthritis 50 41 69
Monarticular Juvenile Rheumatoid Arthritis 12 69
Systemic Juvenile Rheumatoid Arthritis 12 25
Juvenile Chronic Polyarthritis 12 69
Arthritis, Juvenile Rheumatoid 50 25
Juvenile-Onset Still Disease 71 69
Juvenile Chronic Arthritis 50 25
Rheumatoid Arthritis, Systemic Juvenile, Susceptibility to 13
Acute Polyarticular Juvenile Rheumatoid Arthritis 69
Pauciarticular Onset Juvenile Chronic Arthritis 12
Systemic-Onset Juvenile Idiopathic Arthritis 56
Pauciarticular Juvenile Rheumatoid Arthritis 69
Systemic Onset Juvenile Chronic Arthritis 69
Rheumatoid Arthritis Systemic Juvenile 71
Acute Juvenile Rheumatoid Arthritis 12
Pauciarticular Juvenile Arthritis 12
Arthritis Juvenile Rheumatoid 52
Systemic Polyarthritis 56
Arthritis, Juvenile 42
Systemic-Onset Jia 56
Stills Disease 52
Still Disease 56
Juvenile Ra 25
Rasj 71
Jia 25
Jra 25

Characteristics:

Orphanet epidemiological data:

56
systemic-onset juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Europe); Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



Summaries for Rheumatoid Arthritis, Systemic Juvenile

MedlinePlus : 41 juvenile arthritis (ja) is arthritis that happens in children. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, but is more common in the knees, hands, and feet. in some cases it can affect internal organs as well. the most common type of ja that children get is juvenile idiopathic arthritis. there are several other forms of arthritis affecting children. one early sign of ja may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. ja can cause growth problems and eye inflammation in some children. no one knows exactly what causes ja. most types are autoimmune disorders. this means that your immune system, which normally helps your body fight infection, attacks your body's own tissues. ja can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. a team of providers usually treats ja. medicines and physical therapy can help maintain movement and reduce swelling and pain. they may also help prevent and treat complications. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Rheumatoid Arthritis, Systemic Juvenile, also known as juvenile rheumatoid arthritis, is related to rheumatoid arthritis and psoriatic juvenile idiopathic arthritis, and has symptoms including hepatomegaly, splenomegaly and pericarditis. An important gene associated with Rheumatoid Arthritis, Systemic Juvenile is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Alendronate and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye, and related phenotypes are hematopoietic system and immune system

NIH Rare Diseases : 50 juvenile idiopathic arthritis is an autoimmune condition that causes pain and swelling in a child's joints. when the immune system attacks the tissues of the joints, the resulting inflammation can cause joint damage, resulting in the pain and swelling characteristic of the disease. some children who have juvenile idiopathic arthritis are affected by episodes where the symptoms worsen, called flares. like most other autoimmune conditions, juvenile idiopathic arthritis is caused by a combination of genetic and environmental factors. to be diagnosed with juvenile idiopathic arthritis, the symptoms must have begun before age 16. diagnosis of the condition may be based on blood tests, x-rays, and ruling out other similar conditions. treatment options may include medications and  physical therapy. last updated: 1/11/2017

UniProtKB/Swiss-Prot : 71 Rheumatoid arthritis systemic juvenile: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

Genetics Home Reference : 25 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Disease Ontology : 12 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Wikipedia : 72 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis, is the most common... more...

Description from OMIM: 604302

Related Diseases for Rheumatoid Arthritis, Systemic Juvenile

Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile

Diseases related to Rheumatoid Arthritis, Systemic Juvenile via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.1 CRP HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1
2 psoriatic juvenile idiopathic arthritis 12.5
3 enthesitis-related juvenile idiopathic arthritis 11.4
4 rheumatoid factor-positive polyarticular juvenile idiopathic arthritis 11.2
5 arthropathy, progressive pseudorheumatoid, of childhood 11.2
6 multicentric carpotarsal osteolysis syndrome 11.2
7 systemic onset juvenile idiopathic arthritis 11.1
8 rheumatoid factor-negative juvenile idiopathic arthritis 11.1
9 polyarticular onset juvenile idiopathic arthritis 11.1
10 smarca4-deficient sarcoma of thorax 11.0 IL6 TNF
11 adult-onset still's disease 11.0
12 anencephaly and spina bifida x-linked 11.0 HLA-DRB1 IL6 TNF
13 lymphocytic colitis 11.0 HLA-DRB1 IL6 TNF
14 riboflavin transporter deficiency 11.0 HLA-DRB1 MIF TNF
15 mosaic trisomy 1 11.0 HLA-DPB1 HLA-DRB1 TNF
16 collagenopathy type 2 alpha 1 11.0 CRP IL6
17 cicatricial lagophthalmos 11.0 CRP IL6 TNF
18 shoulder impingement syndrome 11.0 CRP IL1RN IL6
19 hepadnavirus infection 11.0 HLA-DRB1 IL6 TNF
20 islet cell tumor 11.0 CRP IL6 TNF
21 placental abruption 11.0 CRP IL6 TNF
22 indolent myeloma 11.0 IL1RN IL6 TNF
23 spirillary rat-bite fever 10.9 IL6 LTA TNF
24 toxoplasmosis 10.9 IL6 LTA TNF
25 myeloid sarcoma 10.9 CRP IL6 TNF
26 scrotal carcinoma 10.9 IL1A IL6 TNF
27 walker dyson syndrome 10.9 IL1R1 IL1RN TNF
28 signet ring cell adenocarcinoma 10.9 CRP IL1R1 TNF
29 tracheal stenosis 10.9 HLA-DPB1 IL6 TNF
30 residual stage corticosteroid-induced glaucoma 10.9 CRP IL6 TNF
31 disease of mental health 10.9 HLA-DRB1 IL6 TNF
32 levator syndrome 10.9 IL1R1 IL6 TNF
33 c1 inhibitor deficiency 10.9 CRP IL6 TNF
34 epidermolysis bullosa simplex superficialis 10.9 HLA-DRB1 MIF TNFRSF1B
35 functional gastric disease 10.9 CRP IL1R1 TNF
36 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.9 IL1A IL6 TNF
37 autoimmune retinopathy 10.9 HLA-DRB1 IL2RA TNF
38 breast disease 10.9 CRP IL6 TNF
39 scleroperikeratitis 10.9 IL1RN TNF TNFRSF1B
40 bardet-biedl syndrome 8 10.9 CRP IL6 TNF
41 newborn respiratory distress syndrome 10.9 HLA-DPB1 HLA-DRB1 IL6
42 noma 10.9 IL1RN IL6 TNF
43 atrophy of prostate 10.9 CRP IL6 TNF
44 osmotic diarrhea 10.9 IL1RN IL6 TNF
45 erythema elevatum diutinum 10.9 CRP IL6 MRAP
46 ampulla of vater neoplasm 10.9 HLA-DQA1 IL6 TNF
47 pancreas lymphoma 10.9 CRP IL6 TNF
48 hypogonadotropism 10.9 IL6 LTA TNF
49 choroiditis 10.9 CRP IL6 TNF
50 dentinogenesis imperfecta 10.9 HLA-DRB1 IL6 TNF

Graphical network of the top 20 diseases related to Rheumatoid Arthritis, Systemic Juvenile:



Diseases related to Rheumatoid Arthritis, Systemic Juvenile

Symptoms & Phenotypes for Rheumatoid Arthritis, Systemic Juvenile

Clinical features from OMIM:

604302

Human phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:

56 32 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 56 32 occasional (7.5%) Occasional (29-5%) HP:0002240
2 splenomegaly 56 32 occasional (7.5%) Occasional (29-5%) HP:0001744
3 pericarditis 56 32 occasional (7.5%) Occasional (29-5%) HP:0001701
4 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
5 abdominal pain 56 32 occasional (7.5%) Occasional (29-5%) HP:0002027
6 lymphadenopathy 56 32 frequent (33%) Frequent (79-30%) HP:0002716
7 skin rash 56 32 hallmark (90%) Very frequent (99-80%) HP:0000988
8 arthralgia 56 32 hallmark (90%) Very frequent (99-80%) HP:0002829
9 pleural effusion 56 32 occasional (7.5%) Occasional (29-5%) HP:0002202
10 joint swelling 56 32 hallmark (90%) Very frequent (99-80%) HP:0001386
11 anterior uveitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012122
12 elevated erythrocyte sedimentation rate 56 32 hallmark (90%) Very frequent (99-80%) HP:0003565
13 autoimmunity 56 32 hallmark (90%) Very frequent (99-80%) HP:0002960
14 elevated c-reactive protein level 56 32 hallmark (90%) Very frequent (99-80%) HP:0011227
15 juvenile rheumatoid arthritis 56 32 hallmark (90%) Very frequent (99-80%) HP:0005681
16 arthritis 32 hallmark (90%) HP:0001369
17 malabsorption 32 frequent (33%) HP:0002024
18 pericardial effusion 32 occasional (7.5%) HP:0001698
19 joint stiffness 32 frequent (33%) HP:0001387
20 nail pits 32 frequent (33%) HP:0001803
21 uveitis 32 frequent (33%) HP:0000554
22 joint dislocation 32 frequent (33%) HP:0001373
23 psoriasiform dermatitis 32 frequent (33%) HP:0003765
24 generalized hyperkeratosis 32 frequent (33%) HP:0005595
25 abnormality of the pleura 32 frequent (33%) HP:0002103
26 abnormality of the fingernails 32 frequent (33%) HP:0001231
27 mediastinal lymphadenopathy 32 frequent (33%) HP:0100721
28 cartilage destruction 32 frequent (33%) HP:0100773
29 abnormality of the sacroiliac joint 32 frequent (33%) HP:0100781

UMLS symptoms related to Rheumatoid Arthritis, Systemic Juvenile:


back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 HLA-DQA1 IL1A IL1R1 IL1RN IL2RA IL6
2 immune system MP:0005387 9.73 TNFRSF1B CRP HLA-DQA1 IL1A IL1R1 IL1RN
3 neoplasm MP:0002006 9.17 DEK IL1A IL1R1 IL6 MIF TNF

Drugs & Therapeutics for Rheumatoid Arthritis, Systemic Juvenile

Drugs for Rheumatoid Arthritis, Systemic Juvenile (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 2, Phase 3 121268-17-5, 66376-36-1 2088
2
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
3
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5 tannic acid Approved, Nutraceutical Phase 3
6 Antibodies Phase 3,Phase 1,Phase 2
7 gamma-Globulins Phase 3
8 Immunoglobulins Phase 3,Phase 1,Phase 2
9 Immunoglobulins, Intravenous Phase 3
10 Rho(D) Immune Globulin Phase 3
11 Bone Density Conservation Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
14 Analgesics Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antirheumatic Agents Phase 3
19 Gastrointestinal Agents Phase 3
20 Immunosuppressive Agents Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Pharmaceutical Solutions Phase 1
23
Methotrexate Approved 1959-05-2, 59-05-2 126941
24
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
25
leucovorin Approved, Nutraceutical 58-05-9 143 6006
26 Antimetabolites
27 Antimetabolites, Antineoplastic
28 Dermatologic Agents
29 Folic Acid Antagonists
30 Nucleic Acid Synthesis Inhibitors
31 Vitamin B Complex
32 Folate Nutraceutical
33 Vitamin B9 Nutraceutical

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3 Intravenous immunoglobulin
2 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3 Alendronate
3 Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT00889863 Phase 3 canakinumab;placebo
4 Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis Terminated NCT00078806 Phase 3 Enbrel;Placebo
5 Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA) Terminated NCT00886769 Phase 3 Canakinumab;Placebo
6 Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young Adults Completed NCT00534495 Phase 2
7 Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT00426218 Phase 1, Phase 2 ACZ885
8 An Open-Label Trial of Tocilizumab in Schizophrenia Completed NCT01696929 Phase 1 Tocilizumab
9 Tocilizumab in Schizophrenia Recruiting NCT02874573 Phase 1 Tocilizumab;Normal saline
10 Registry of Etanercept (Enbrel®) In Children With Juvenile Rheumatoid Arthritis Completed NCT00078793 Enbrel®
11 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420 Early Phase 1
12 Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic Arthritis Terminated NCT00868751

Search NIH Clinical Center for Rheumatoid Arthritis, Systemic Juvenile

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: arthritis, juvenile

Genetic Tests for Rheumatoid Arthritis, Systemic Juvenile

Genetic tests related to Rheumatoid Arthritis, Systemic Juvenile:

id Genetic test Affiliating Genes
1 Rheumatoid Arthritis, Systemic Juvenile 29

Anatomical Context for Rheumatoid Arthritis, Systemic Juvenile

MalaCards organs/tissues related to Rheumatoid Arthritis, Systemic Juvenile:

39
Testes, Skin, Eye, Bone

Publications for Rheumatoid Arthritis, Systemic Juvenile

Variations for Rheumatoid Arthritis, Systemic Juvenile

Expression for Rheumatoid Arthritis, Systemic Juvenile

Search GEO for disease gene expression data for Rheumatoid Arthritis, Systemic Juvenile.

Pathways for Rheumatoid Arthritis, Systemic Juvenile

Pathways related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 39)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 CRP HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1
2
Show member pathways
13.31 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1 IL1RN
3
Show member pathways
13.28 IL1A IL1R1 IL2RA IL6 LTA TNF
4
Show member pathways
12.77 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL2RA IL6
5
Show member pathways
12.76 IL2RA IL6 LTA TNF TNFRSF1B
6
Show member pathways
12.76 HLA-DPB1 HLA-DQA1 HLA-DRB1 HSPD1 IL1A IL2RA
7
Show member pathways
12.71 IL1A IL1R1 IL6 LTA TNF TNFRSF1B
8
Show member pathways
12.65 IL1A IL1R1 LTA TNF TNFRSF1B
9
Show member pathways
12.64 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA TNF TNFRSF1B
10
Show member pathways
12.59 IL1A IL1R1 LTA TNF TNFRSF1B
11
Show member pathways
12.54 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1 IL2RA
12
Show member pathways
12.26 IL1A IL1R1 IL6 MIF TNF
13
Show member pathways
12.25 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A TNF
14 12.17 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1R1 IL2RA IL6
15 12.16 HSPD1 IL1A IL1RN IL6 TNF
16
Show member pathways
12.15 IL1A IL6 LTA TNF
17 12.05 HLA-DPB1 HLA-DQA1 HLA-DRB1 HSPD1 IL1A IL6
18 11.99 IL1A IL1R1 IL6 MIF TNF
19 11.98 IL1A IL6 TNF TNFRSF1B
20 11.95 IL6 LTA TNF TNFRSF1B
21 11.8 IL1R1 IL2RA LTA TNF
22
Show member pathways
11.78 LTA TNF TNFRSF1B
23
Show member pathways
11.77 HLA-DPB1 HLA-DQA1 HLA-DRB1
24 11.75 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL6 TNF
25 11.73 IL1A IL6 TNF
26 11.72 IL2RA IL6 LTA TNF
27
Show member pathways
11.66 IL1A IL6 MIF TNF
28 11.58 HLA-DPB1 HLA-DQA1 HLA-DRB1
29 11.57 HSPD1 IL6 TNF
30 11.56 IL1A IL1R1 LTA TNF TNFRSF1B
31
Show member pathways
11.52 LTA TNF TNFRSF1B
32 11.48 BGLAP IL1A IL6 TNF
33
Show member pathways
11.41 IL2RA TNF TNFRSF1B
34 11.35 IL1A IL6 TNF
35 11.27 HLA-DRB1 IL1A IL6 TNF
36 11.21 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1 IL2RA
37 11.19 IL1A IL6 LTA TNF
38 11.12 IL1A IL1R1 IL1RN IL6 TNF TNFRSF1B
39 11.05 CRP IL6 TNF

GO Terms for Rheumatoid Arthritis, Systemic Juvenile

Cellular components related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 BGLAP CRP HSPD1 IL1A IL1RN IL6
2 trans-Golgi network membrane GO:0032588 9.65 HLA-DPB1 HLA-DQA1 HLA-DRB1
3 endocytic vesicle membrane GO:0030666 9.63 HLA-DPB1 HLA-DQA1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.61 HLA-DPB1 HLA-DQA1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.58 HLA-DPB1 HLA-DQA1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.54 HLA-DPB1 HLA-DQA1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.5 HLA-DPB1 HLA-DQA1 HLA-DRB1
8 cell surface GO:0009986 9.5 HLA-DPB1 HLA-DRB1 HSPD1 IL1R1 IL2RA MIF
9 MHC class II protein complex GO:0042613 9.43 HLA-DPB1 HLA-DQA1 HLA-DRB1
10 extracellular region GO:0005576 9.4 BGLAP CRP HAPLN1 IL1A IL1R1 IL1RN

Biological processes related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL2RA MIF S100A9
2 regulation of cell proliferation GO:0042127 9.91 IL6 MIF TNF TNFRSF1B
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 HSPD1 S100A9 TNF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 IL6 MIF TNF
5 T cell costimulation GO:0031295 9.79 HLA-DPB1 HLA-DQA1 HLA-DRB1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.77 HLA-DPB1 HLA-DQA1 HLA-DRB1
7 positive regulation of T cell proliferation GO:0042102 9.77 HLA-DPB1 IL2RA IL6
8 humoral immune response GO:0006959 9.76 IL6 LTA TNF
9 antigen processing and presentation GO:0019882 9.73 HLA-DPB1 HLA-DQA1 HLA-DRB1
10 defense response to Gram-positive bacterium GO:0050830 9.73 CRP IL6 LTA TNF
11 response to glucocorticoid GO:0051384 9.71 BGLAP IL1RN IL6 TNF
12 positive regulation of cytokine secretion GO:0050715 9.65 IL1A MIF TNF
13 inflammatory response to antigenic stimulus GO:0002437 9.63 HLA-DRB1 IL2RA
14 positive regulation of interleukin-6 production GO:0032755 9.62 HSPD1 IL1A IL6 TNF
15 inflammatory response GO:0006954 9.61 CRP IL1A IL1RN IL2RA IL6 MIF
16 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
17 positive regulation of neutrophil extravasation GO:2000391 9.55 IL1A IL1R1
18 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.54 LTA TNF
19 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DPB1 HLA-DQA1 HLA-DRB1
20 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.52 IL1RN IL6
21 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.51 MIF TNF
22 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.46 LTA TNF
23 positive regulation of interferon-gamma production GO:0032729 9.46 HLA-DPB1 HSPD1 LTA TNF
24 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
25 immune response GO:0006955 9.36 HLA-DPB1 HLA-DQA1 HLA-DRB1 IL1A IL1R1 IL1RN
26 fever generation GO:0001660 9.27 IL1A

Molecular functions related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.16 HLA-DQA1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.13 HLA-DPB1 HLA-DQA1 HLA-DRB1
3 cytokine activity GO:0005125 9.1 IL1A IL1RN IL6 LTA MIF TNF

Sources for Rheumatoid Arthritis, Systemic Juvenile

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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