Rheumatoid Arthritis, Systemic Juvenile malady
Categories: Genetic diseases, Rare diseases, Respiratory diseases, Bone diseases
Aliases & Descriptions for Rheumatoid Arthritis, Systemic Juvenile:
Orphanet epidemiological data:53
systemic-onset juvenile idiopathic arthritis:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Europe); Age of onset: Childhood; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases, Bone diseases
ICD10: 30 29
MedlinePlus:37 Juvenile arthritis (ja) is arthritis that happens in children. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, but is more common in the knees, hands, and feet. in some cases it can affect internal organs as well. the most common type of ja that children get is juvenile idiopathic arthritis. there are several other forms of arthritis affecting children. one early sign of ja may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. ja can cause growth problems and eye inflammation in some children. no one knows exactly what causes ja. most types are autoimmune disorders. this means that your immune system, which normally helps your body fight infection, attacks your body's own tissues. ja can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. a team of providers usually treats ja. medicines and physical therapy can help maintain movement and reduce swelling and pain. they may also help prevent and treat complications. nih: national institute of arthritis and musculoskeletal and skin diseases
MalaCards based summary: Rheumatoid Arthritis, Systemic Juvenile, also known as juvenile rheumatoid arthritis, is related to rheumatoid arthritis and polyarticular onset juvenile idiopathic arthritis, and has symptoms including skin rash, arthritis and joint swelling. An important gene associated with Rheumatoid Arthritis, Systemic Juvenile is IL6 (Interleukin 6), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and Legionellosis. The drugs diclofenac potassium and naproxen have been mentioned in the context of this disorder. Affiliated tissues include joint, eye and testes, and related mouse phenotypes are hematopoietic system and neoplasm.
UniProtKB/Swiss-Prot:69 Rheumatoid arthritis systemic juvenile: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Genetics Home Reference:25 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.
Disease Ontology:11 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.
Wikipedia:70 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...
Description from OMIM:51 604302
Clinical features from OMIM:604302
Human phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:63 53 (show all 31)
UMLS symptoms related to Rheumatoid Arthritis, Systemic Juvenile:back pain, muscle cramp, sciatica
Drugs for Rheumatoid Arthritis, Systemic Juvenile (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 148)
Interventional clinical trials:(show top 50) (show all 197)
Search NIH Clinical Center for Rheumatoid Arthritis, Systemic Juvenile
Inferred drug relations via UMLS67/NDF-RT45:
Genetic tests related to Rheumatoid Arthritis, Systemic Juvenile:
MalaCards organs/tissues related to Rheumatoid Arthritis, Systemic Juvenile:35
Eye, Testes, Skin, Bone, Kidney, Colon, Liver
FMA organs/tissues related to Rheumatoid Arthritis, Systemic Juvenile:17
MGI Mouse Phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:40
Search GEO for disease gene expression data for Rheumatoid Arthritis, Systemic Juvenile.
Pathways related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:(show all 33)
Cellular components related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:(show all 11)
Biological processes related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:(show all 21)
Molecular functions related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet