MCID: RHM021
MIFTS: 26

Rheumatoid Arthritis, Systemic Juvenile malady

Genetic diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Rheumatoid Arthritis, Systemic Juvenile

About this section
Sources:
45OMIM, 43Novoseek
See all sources

Rheumatoid Arthritis, Systemic Juvenile, Aliases & Descriptions:

Name: Rheumatoid Arthritis, Systemic Juvenile 45 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases


External Ids:

OMIM45 604302

Summaries for Rheumatoid Arthritis, Systemic Juvenile

About this section


MalaCards based summary: Rheumatoid Arthritis, Systemic Juvenile is related to juvenile rheumatoid arthritis and arteriosclerosis. An important gene associated with Rheumatoid Arthritis, Systemic Juvenile is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Pathways in cancer and Interferon Signaling. The compounds su 11274 and pf 04217903 mesylate have been mentioned in the context of this disorder. Related mouse phenotype hematopoietic system.

Description from OMIM:45 604302

Related Diseases for Rheumatoid Arthritis, Systemic Juvenile

About this section

Graphical network of the top 20 diseases related to Rheumatoid Arthritis, Systemic Juvenile:



Diseases related to rheumatoid arthritis, systemic juvenile

Symptoms for Rheumatoid Arthritis, Systemic Juvenile

About this section


Clinical features from OMIM:

604302

Drugs & Therapeutics for Rheumatoid Arthritis, Systemic Juvenile

About this section

Drug clinical trials:

Search ClinicalTrials for Rheumatoid Arthritis, Systemic Juvenile

Search NIH Clinical Center for Rheumatoid Arthritis, Systemic Juvenile

Genetic Tests for Rheumatoid Arthritis, Systemic Juvenile

About this section

Anatomical Context for Rheumatoid Arthritis, Systemic Juvenile

About this section

Animal Models for Rheumatoid Arthritis, Systemic Juvenile or affiliated genes

About this section

MGI Mouse Phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5HGF, IL6, MIF

Publications for Rheumatoid Arthritis, Systemic Juvenile

About this section

Variations for Rheumatoid Arthritis, Systemic Juvenile

About this section

Expression for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

About this section
Search GEO for disease gene expression data for Rheumatoid Arthritis, Systemic Juvenile.

Pathways for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

About this section

Pathways related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HGF, IL6
2
Show member pathways
9.3IL6, HGF
39.3IL6, HGF
4
Show member pathways
9.3IL6, HGF
5
Show member pathways
9.3IL6, HGF
6
Show member pathways
9.3IL6, HGF
79.3IL6, HGF
8
Show member pathways
Immune response MIF in innate immunity response58
9.0IL6, MIF
99.0MIF, IL6
109.0IL6, MIF
119.0IL6, MIF
12
Show member pathways
8.5IL6, MIF, HGF

Compounds for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

About this section

Compounds related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1su 11274599.8IL6, HGF
2pf 04217903 mesylate599.8HGF, IL6
3pha 665752599.8IL6, HGF
4rebamipide439.8HGF, IL6
5crizotinib59 4910.8HGF, IL6
6filgrastim43 1210.8IL6, HGF
7pmma439.7HGF, IL6
8dextran sulfate439.7IL6, HGF
9pdtc439.7IL6, HGF
10pge1439.7IL6, HGF
11aprotinin43 1210.7IL6, HGF
12sp 60012543 5910.7IL6, HGF
13prednisolone43 28 1211.7HGF, IL6
14tgf beta1439.7HGF, IL6
15hyaluronic acid43 2410.7IL6, HGF
16methotrexate49 43 1211.6HGF, IL6
17n acetylcysteine439.6IL6, HGF
18indomethacin43 28 59 1212.5HGF, IL6
19vitamin d439.5HGF, IL6
20acetaminophen43 2 49 24 1213.5HGF, MIF
21cyclophosphamide43 49 1211.5MIF, HGF
22histamine43 28 2411.4IL6, HGF
23nacl439.4HGF, MIF
24pd 98,059439.4IL6, HGF
25endotoxin439.3IL6, MIF
26curcumin439.3IL6, MIF
27ly294002439.3IL6, HGF
28acth439.3IL6, MIF
29paclitaxel43 49 1211.3MIF, HGF
30rantes439.3IL6, MIF
31estradiol43 24 1211.1MIF, HGF
32doxorubicin43 49 1211.0HGF, MIF
33actinomycin d439.0IL6, HGF
34thalidomide43 49 59 1212.0MIF, IL6, HGF
35hydrocortisone43 2 59 1212.0IL6, HGF, MIF
36herbimycin a43 5910.0IL6, HGF, MIF
37sb 20358043 599.9IL6, HGF, MIF
38norepinephrine43 24 1210.9MIF, HGF, IL6
39genistein43 28 59 2 24 1213.9HGF, MIF, IL6
40pge2438.9HGF, IL6, MIF
41lactate438.9HGF, IL6, MIF
42thymidine43 249.9HGF, IL6, MIF
43creatinine438.9HGF, MIF, IL6
44dexamethasone43 49 28 1211.9HGF, IL6, MIF
45vegf438.9IL6, MIF, HGF
46alanine438.9IL6, MIF, HGF
47estrogen438.9MIF, HGF, IL6
48retinoic acid43 249.9MIF, HGF, IL6
49lipid438.9MIF, HGF, IL6
50tyrosine438.8HGF, IL6, MIF

GO Terms for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

About this section

Cellular components related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5HGF, IL6, MIF
2extracellular spaceGO:00056158.2HGF, IL6, MIF

Biological processes related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.4HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3HGF, IL6
3positive chemotaxisGO:00509189.3MIF, HGF
4positive regulation of peptidyl-serine phosphorylationGO:00331389.1MIF, IL6
5platelet activationGO:00301689.0IL6, HGF
6inflammatory responseGO:00069549.0MIF, IL6
7positive regulation of ERK1 and ERK2 cascadeGO:00703748.9IL6, MIF
8positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.7IL6, HGF, MIF
9negative regulation of apoptotic processGO:00430668.7MIF, IL6, HGF

Molecular functions related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL6, MIF
2growth factor activityGO:00080839.0HGF, IL6
3chemoattractant activityGO:00420569.0HGF, MIF

Products for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Rheumatoid Arthritis, Systemic Juvenile

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet