MCID: RHM021
MIFTS: 26

Rheumatoid Arthritis, Systemic Juvenile malady

Genetic diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Rheumatoid Arthritis, Systemic Juvenile

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Sources:
46OMIM, 44Novoseek
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Aliases & Descriptions for Rheumatoid Arthritis, Systemic Juvenile:

Name: Rheumatoid Arthritis, Systemic Juvenile 46 44


Classifications:



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OMIM46 604302

Summaries for Rheumatoid Arthritis, Systemic Juvenile

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MalaCards based summary: Rheumatoid Arthritis, Systemic Juvenile is related to juvenile rheumatoid arthritis and arteriosclerosis. An important gene associated with Rheumatoid Arthritis, Systemic Juvenile is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Pathways in cancer and PI3K-Akt signaling pathway. The compounds su 11274 and pf 04217903 mesylate have been mentioned in the context of this disorder. Related mouse phenotype hematopoietic system.

Description from OMIM:46 604302

Related Diseases for Rheumatoid Arthritis, Systemic Juvenile

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Graphical network of the top 20 diseases related to Rheumatoid Arthritis, Systemic Juvenile:



Diseases related to rheumatoid arthritis, systemic juvenile

Symptoms for Rheumatoid Arthritis, Systemic Juvenile

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Clinical features from OMIM:

604302

Drugs & Therapeutics for Rheumatoid Arthritis, Systemic Juvenile

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Drug clinical trials:

Search ClinicalTrials for Rheumatoid Arthritis, Systemic Juvenile

Search NIH Clinical Center for Rheumatoid Arthritis, Systemic Juvenile

Genetic Tests for Rheumatoid Arthritis, Systemic Juvenile

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Anatomical Context for Rheumatoid Arthritis, Systemic Juvenile

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Animal Models for Rheumatoid Arthritis, Systemic Juvenile or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Arthritis, Systemic Juvenile:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5HGF, IL6, MIF

Publications for Rheumatoid Arthritis, Systemic Juvenile

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Variations for Rheumatoid Arthritis, Systemic Juvenile

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Expression for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

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Search GEO for disease gene expression data for Rheumatoid Arthritis, Systemic Juvenile.

Pathways for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

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Pathways related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HGF, IL6
29.3HGF, IL6
3
Show member pathways
9.3HGF, IL6
4
Show member pathways
9.3HGF, IL6
59.3HGF, IL6
6
Show member pathways
9.3IL6, HGF
7
Show member pathways
9.3IL6, HGF
8
Show member pathways
Immune response MIF in innate immunity response59
9.0IL6, MIF
99.0IL6, MIF
109.0IL6, MIF
119.0IL6, MIF
12
Show member pathways
8.5MIF, IL6, HGF

Compounds for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

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Compounds related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1su 11274609.8IL6, HGF
2pf 04217903 mesylate609.8HGF, IL6
3pha 665752609.8IL6, HGF
4rebamipide449.8HGF, IL6
5crizotinib60 5010.8HGF, IL6
6filgrastim44 1110.8IL6, HGF
7pmma449.7HGF, IL6
8dextran sulfate449.7IL6, HGF
9pdtc449.7IL6, HGF
10pge1449.7IL6, HGF
11aprotinin44 1110.7IL6, HGF
12sp 60012544 6010.7IL6, HGF
13prednisolone44 28 1111.7HGF, IL6
14tgf beta1449.7HGF, IL6
15hyaluronic acid44 2410.7IL6, HGF
16methotrexate50 44 1111.6HGF, IL6
17n acetylcysteine449.6IL6, HGF
18indomethacin44 28 60 1112.5HGF, IL6
19vitamin d449.5HGF, IL6
20acetaminophen44 1 50 24 1113.5HGF, MIF
21cyclophosphamide44 50 1111.5MIF, HGF
22histamine44 28 2411.4IL6, HGF
23nacl449.4HGF, MIF
24pd 98,059449.4IL6, HGF
25endotoxin449.3IL6, MIF
26curcumin449.3IL6, MIF
27ly294002449.3IL6, HGF
28acth449.3IL6, MIF
29paclitaxel44 50 1111.3MIF, HGF
30rantes449.3IL6, MIF
31estradiol44 24 1111.1MIF, HGF
32doxorubicin44 50 1111.0HGF, MIF
33actinomycin d449.0IL6, HGF
34thalidomide44 50 60 1112.0MIF, IL6, HGF
35hydrocortisone44 1 60 1112.0IL6, HGF, MIF
36herbimycin a44 6010.0IL6, HGF, MIF
37sb 20358044 609.9IL6, HGF, MIF
38norepinephrine44 24 1110.9MIF, HGF, IL6
39genistein44 28 60 1 24 1113.9HGF, MIF, IL6
40pge2448.9HGF, IL6, MIF
41lactate448.9HGF, IL6, MIF
42thymidine44 249.9HGF, IL6, MIF
43creatinine448.9HGF, MIF, IL6
44dexamethasone44 50 28 1111.9HGF, IL6, MIF
45vegf448.9IL6, MIF, HGF
46alanine448.9IL6, MIF, HGF
47estrogen448.9MIF, HGF, IL6
48retinoic acid44 249.9MIF, HGF, IL6
49lipid448.9MIF, HGF, IL6
50tyrosine448.8HGF, IL6, MIF

GO Terms for genes affiliated with Rheumatoid Arthritis, Systemic Juvenile

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Cellular components related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5HGF, IL6, MIF
2extracellular spaceGO:00056158.2HGF, IL6, MIF

Biological processes related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:00456699.4IL6, HGF
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3HGF, IL6
3positive chemotaxisGO:00509189.3HGF, MIF
4positive regulation of peptidyl-serine phosphorylationGO:00331389.1IL6, MIF
5platelet activationGO:00301689.0HGF, IL6
6inflammatory responseGO:00069549.0IL6, MIF
7positive regulation of ERK1 and ERK2 cascadeGO:00703748.9IL6, MIF
8positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.7HGF, IL6, MIF
9negative regulation of apoptotic processGO:00430668.7MIF, IL6, HGF

Molecular functions related to Rheumatoid Arthritis, Systemic Juvenile according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IL6, MIF
2growth factor activityGO:00080839.0HGF, IL6
3chemoattractant activityGO:00420569.0HGF, MIF

Sources for Rheumatoid Arthritis, Systemic Juvenile

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet