MCID: RHM032
MIFTS: 38

Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

Name: Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis 56
Juvenile Rheumatoid Factor-Negative Polyarthritis 56
Polyarthritis Without Rheumatoid Factor 56
Rheumatoid Factor-Negative Jia 56

Characteristics:

Orphanet epidemiological data:

56
rheumatoid factor-negative juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy;

Classifications:



Summaries for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards based summary : Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis, also known as juvenile rheumatoid factor-negative polyarthritis, is related to rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies and rheumatoid factor-negative juvenile idiopathic arthritis with anti-nuclear antibodies, and has symptoms including dental malocclusion, joint dislocation and limitation of joint mobility. An important gene associated with Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Adalimumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Related Diseases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 12.4
2 rheumatoid factor-negative juvenile idiopathic arthritis with anti-nuclear antibodies 12.4
3 celiac disease 3 10.6 HLA-DRB1 SLC11A1
4 clopidogrel resistance 10.6 HLA-DRB1 PTPN22
5 not otherwise specified 3-mga-uria type 10.5 HLA-DRB1 SLC11A1
6 humero-ulnar synostosis 10.4 PTPN22 STAT4
7 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 10.4 HLA-DRB1 STAT4
8 juvenile sialidosis type 2 10.4 FAS HLA-DRB1
9 autoimmune retinopathy 10.4 HLA-DRB1 IL2RA
10 patau syndrome 10.3 HLA-DRB1 PTPN22
11 cerebral sarcoidosis 10.3 HLA-DRB1 IL2RA
12 macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations 10.2 FAS TYK2
13 blood group incompatibility 10.2 FAS HLA-DRB1
14 diffuse scleroderma 10.2 HLA-DRB1 IL2RA
15 inflammatory bowel disease 3 10.1 HLA-DRB1 IL2RA SLC11A1
16 pulsating exophthalmos 10.0 HLA-DRB1 IL2RA PTPN22
17 esophagus melanoma 10.0 IL2RA SLC11A1
18 arthritis 9.9
19 atherosclerosis 9.9 HLA-DRB1 PTPN22 STAT4
20 rheumatoid arthritis 9.8 HLA-DRB1 PTPN22 SLC11A1 STAT4
21 diabetes mellitus, insulin-dependent, 12 9.8 FAS IL2RA PTPN22
22 immunodeficiency 11a 9.8 IL2RA IL2RB
23 iida kannari syndrome 9.8 HLA-DRB1 IL2RA
24 goodpasture syndrome 9.7 FAS IL2RA STAT4
25 pseudohypoparathyroidism 9.7 FAS HLA-DRB1 PTPN22 STAT4
26 hepatitis b 9.7 FAS IL2RA IL2RB
27 systemic lupus erythematosus 9.6 HLA-DRB1 IL2RA PTPN22 STAT4
28 anterior corneal pigmentation 9.6 FAS HLA-DRB1 IL2RA PTPN22
29 smoking as a quantitative trait locus 1 9.5 FAS IL2RA IL2RB
30 kaposi sarcoma 9.3 HLA-DRB1 IL2RA IL2RB PTPN22 SLC11A1
31 atypical lichen myxedematosus 6.8 ANKRD55 CD247 FAS IL2RA IL2RB PTPN2
32 alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome 6.2 ANKRD55 CD247 FAS HLA-DRB1 IL2RA IL2RB

Graphical network of the top 20 diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:



Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Human phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

56 32 (show all 11)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dental malocclusion 56 32 hallmark (90%) Very frequent (99-80%) HP:0000689
2 joint dislocation 56 32 hallmark (90%) Very frequent (99-80%) HP:0001373
3 limitation of joint mobility 56 32 hallmark (90%) Very frequent (99-80%) HP:0001376
4 joint swelling 56 32 hallmark (90%) Very frequent (99-80%) HP:0001386
5 apraxia 56 32 hallmark (90%) Very frequent (99-80%) HP:0002186
6 arthralgia 56 32 hallmark (90%) Very frequent (99-80%) HP:0002829
7 antinuclear antibody positivity 56 32 hallmark (90%) Very frequent (99-80%) HP:0003493
8 elevated erythrocyte sedimentation rate 56 32 hallmark (90%) Very frequent (99-80%) HP:0003565
9 juvenile rheumatoid arthritis 56 32 hallmark (90%) Very frequent (99-80%) HP:0005681
10 polyarticular arthritis 56 32 hallmark (90%) Very frequent (99-80%) HP:0005764
11 elevated c-reactive protein level 56 32 hallmark (90%) Very frequent (99-80%) HP:0011227

GenomeRNAi Phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.8 IL2RA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.8 HLA-DRB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.8 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.8 HLA-DRB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.8 FAS HLA-DRB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.8 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.8 FAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.8 IL2RA HLA-DRB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.8 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.8 HLA-DRB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.8 IL2RA FAS HLA-DRB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.8 FAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.8 HLA-DRB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.8 FAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.8 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.8 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.8 FAS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.8 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.8 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.8 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.8 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.8 HLA-DRB1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.8 IL2RA

MGI Mouse Phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 PTPN2 PTPN22 SLC11A1 STAT4 CD247 TYK2
2 endocrine/exocrine gland MP:0005379 9.8 PTPN2 PTPN22 STAT4 CD247 FAS IL2RA
3 immune system MP:0005387 9.61 PTPN2 PTPN22 SLC11A1 STAT4 CD247 TYK2
4 mortality/aging MP:0010768 9.28 PTPN2 PTPN22 SLC11A1 STAT4 CD247 TYK2

Drugs & Therapeutics for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Drugs for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 3 331731-18-1 16219006
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3
Abatacept Approved Phase 3 332348-12-6 10237
4
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
5 tannic acid Approved, Nutraceutical Phase 3
6 Analgesics Phase 3
7 Rheumatoid Factor Phase 3
8 Gastrointestinal Agents Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Immunosuppressive Agents Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antirheumatic Agents Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment Tapering in JIA With Inactive Disease Recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
2 Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry Recruiting NCT02418442

Search NIH Clinical Center for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Genetic Tests for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Anatomical Context for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

39
Bone, Eye

Publications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Articles related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

id Title Authors Year
1
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. ( 15641099 )
2005

Variations for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Expression for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis.

Pathways for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Pathways related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CD247 HLA-DRB1 IL2RA IL2RB PTPN2 PTPN22
2
Show member pathways
13.12 HLA-DRB1 IL2RA IL2RB PTPN2 TYK2
3
Show member pathways
13.04 FAS IL2RA IL2RB PTPN2 PTPN22
4
Show member pathways
12.61 CD247 FAS HLA-DRB1 IL2RA
5
Show member pathways
12.6 FAS HLA-DRB1 IL2RA IL2RB TYK2
6 12.45 FAS IL2RA IL2RB TYK2
7
Show member pathways
12.27 CD247 HLA-DRB1 IL2RA IL2RB STAT4 TYK2
8 12.21 HLA-DRB1 IL2RA IL2RB
9
Show member pathways
12.21 CD247 HLA-DRB1 IL2RA IL2RB
10
Show member pathways
12.12 CD247 HLA-DRB1 PTPN22
11 12 FAS IL2RA IL2RB PTPN2 PTPN22 STAT4
12
Show member pathways
11.96 IL2RA IL2RB PTPN2 STAT4 TYK2
13
Show member pathways
11.76 CD247 HLA-DRB1 PTPN22
14 11.68 IL2RA IL2RB STAT4 TYK2
15 11.56 CD247 HLA-DRB1 PTPN22
16
Show member pathways
11.55 CD247 HLA-DRB1
17
Show member pathways
11.45 CD247 IL2RA IL2RB STAT4
18 11.34 IL2RA IL2RB STAT4
19 11.27 PTPN2 STAT4 TYK2
20
Show member pathways
11.23 FAS IL2RA IL2RB
21
Show member pathways
11.2 STAT4 TYK2
22
Show member pathways
11.15 CD247 HLA-DRB1 IL2RA IL2RB STAT4 TYK2
23 11.1 IL2RA IL2RB
24
Show member pathways
11.04 IL2RA STAT4 TYK2
25 10.9 CD247 HLA-DRB1 IL2RA STAT4

GO Terms for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Cellular components related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 FAS HLA-DRB1 IL2RA IL2RB

Biological processes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 FAS HLA-DRB1 IL2RA SLC11A1
2 response to lipopolysaccharide GO:0032496 9.58 FAS PTPN22 SLC11A1
3 T cell receptor signaling pathway GO:0050852 9.5 CD247 HLA-DRB1 PTPN22
4 negative regulation of T cell proliferation GO:0042130 9.48 HLA-DRB1 IL2RA
5 T cell differentiation GO:0030217 9.46 PTPN2 PTPN22
6 T cell homeostasis GO:0043029 9.43 FAS IL2RA
7 negative regulation of T cell receptor signaling pathway GO:0050860 9.26 PTPN2 PTPN22
8 inflammatory response to antigenic stimulus GO:0002437 9.16 HLA-DRB1 IL2RA
9 activation-induced cell death of T cells GO:0006924 8.96 FAS IL2RA
10 interleukin-2-mediated signaling pathway GO:0038110 8.62 IL2RA IL2RB

Molecular functions related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.16 CD247 PTPN22
2 interleukin-2 binding GO:0019976 8.96 IL2RA IL2RB
3 interleukin-2 receptor activity GO:0004911 8.62 IL2RA IL2RB

Sources for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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