MCID: RHM032
MIFTS: 37

Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Categories: Bone diseases, Eye diseases, Respiratory diseases, Rare diseases

Aliases & Classifications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

Name: Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis 55
Juvenile Rheumatoid Factor-Negative Polyarthritis 55
Polyarthritis Without Rheumatoid Factor 55
Rheumatoid Factor-Negative Jia 55

Characteristics:

Orphanet epidemiological data:

55
rheumatoid factor-negative juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy;

Classifications:



Summaries for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards based summary : Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis, also known as juvenile rheumatoid factor-negative polyarthritis, is related to arthritis and rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies, and has symptoms including dental malocclusion, joint dislocation and limitation of joint mobility. An important gene associated with Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include bone and eye, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 arthritis 29.9 HLA-DRB1 PTPN22 STAT4
2 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 12.5
3 rheumatoid factor-negative juvenile idiopathic arthritis with anti-nuclear antibodies 12.5
4 type 1 diabetes mellitus 12 10.4 HLA-DRB1 SLC11A1
5 autoimmune addison disease 10.3 HLA-DRB1 PTPN22
6 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 SLC11A1
7 diffuse cutaneous systemic sclerosis 10.2 HLA-DRB1 STAT4
8 pediatric systemic lupus erythematosus 10.2 PTPN22 STAT4
9 palindromic rheumatism 10.2 HLA-DRB1 PTPN22
10 rheumatoid arthritis, systemic juvenile 10.2 HLA-DRB1 IL2RB
11 pure red-cell aplasia 10.1 HLA-DRB1 IL2RA
12 anterior uveitis 10.1 IL2RA PTPN22
13 limited scleroderma 10.1 HLA-DRB1 IL2RA
14 idiopathic neutropenia 10.0 HLA-DRB1 IL2RA
15 juvenile rheumatoid arthritis 9.9 HLA-DRB1 IL2RA SLC11A1
16 sarcoidosis 1 9.9 HLA-DRB1 IL2RA SLC11A1
17 vogt-koyanagi-harada disease 9.9 HLA-DRB1 IL2RA PTPN22
18 brucellosis 9.9 IL2RA SLC11A1
19 graves' disease 9.9 HLA-DRB1 IL2RA PTPN22
20 temporal arteritis 9.9 HLA-DRB1 PTPN22
21 mumps 9.8 HLA-DRB1 IL2RA
22 b-cell expansion with nfkb and t-cell anergy 9.8 IL2RA IL2RB
23 rheumatoid arthritis 9.8 HLA-DRB1 PTPN22 SLC11A1 STAT4
24 diabetes mellitus, insulin-dependent 9.8 HLA-DRB1 IL2RA PTPN22
25 inflammatory bowel disease 9.7 HLA-DRB1 PTPN22 SLC11A1 STAT4
26 autoimmune disease 9.6 HLA-DRB1 IL2RA PTPN22 STAT4
27 systemic lupus erythematosus 9.2 CD247 HLA-DRB1 IL2RA PTPN22 STAT4
28 oligoarticular juvenile idiopathic arthritis 7.6 ANKRD55 CD247 HLA-DRB1 IL2RA IL2RB PTPN2

Graphical network of the top 20 diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:



Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Human phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

55 31 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dental malocclusion 55 31 hallmark (90%) Very frequent (99-80%) HP:0000689
2 joint dislocation 55 31 hallmark (90%) Very frequent (99-80%) HP:0001373
3 limitation of joint mobility 55 31 hallmark (90%) Very frequent (99-80%) HP:0001376
4 joint swelling 55 31 hallmark (90%) Very frequent (99-80%) HP:0001386
5 apraxia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002186
6 arthralgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002829
7 antinuclear antibody positivity 55 31 hallmark (90%) Very frequent (99-80%) HP:0003493
8 elevated erythrocyte sedimentation rate 55 31 hallmark (90%) Very frequent (99-80%) HP:0003565
9 juvenile rheumatoid arthritis 55 31 hallmark (90%) Very frequent (99-80%) HP:0005681
10 polyarticular arthritis 55 31 hallmark (90%) Very frequent (99-80%) HP:0005764
11 elevated c-reactive protein level 55 31 hallmark (90%) Very frequent (99-80%) HP:0011227

MGI Mouse Phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1
2 endocrine/exocrine gland MP:0005379 9.73 CD247 IL2RA IL2RB PTPN2 PTPN22 STAT4
3 immune system MP:0005387 9.56 TYK2 CD247 IL2RA IL2RB PTPN2 PTPN22
4 mortality/aging MP:0010768 9.23 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1

Drugs & Therapeutics for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search Clinical Trials , NIH Clinical Center for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Genetic Tests for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Anatomical Context for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

38
Bone, Eye

Publications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Articles related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

# Title Authors Year
1
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. ( 15641099 )
2005

Variations for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Expression for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis.

Pathways for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Pathways related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CD247 HLA-DRB1 IL2RA IL2RB PTPN2 PTPN22
2
Show member pathways
13.08 HLA-DRB1 IL2RA IL2RB PTPN2 TYK2
3
Show member pathways
12.54 HLA-DRB1 IL2RA IL2RB TYK2
4
Show member pathways
12.27 CD247 HLA-DRB1 IL2RA IL2RB STAT4 TYK2
5 12.19 HLA-DRB1 IL2RA IL2RB
6
Show member pathways
12.18 CD247 HLA-DRB1 IL2RA IL2RB
7 12.15 IL2RA IL2RB PTPN2 PTPN22 STAT4 TYK2
8
Show member pathways
12.1 CD247 HLA-DRB1 PTPN22
9
Show member pathways
12.1 IL2RA IL2RB PTPN2 STAT4 TYK2
10
Show member pathways
11.74 CD247 HLA-DRB1 PTPN22
11 11.64 IL2RA IL2RB STAT4 TYK2
12
Show member pathways
11.55 CD247 HLA-DRB1
13 11.54 CD247 HLA-DRB1 PTPN22
14
Show member pathways
11.45 CD247 IL2RA IL2RB STAT4
15 11.35 STAT4 TYK2
16 11.32 IL2RA IL2RB STAT4
17 11.23 PTPN2 STAT4 TYK2
18
Show member pathways
11.19 STAT4 TYK2
19
Show member pathways
11.15 CD247 HLA-DRB1 IL2RA IL2RB STAT4 TYK2
20
Show member pathways
11.14 IL2RA IL2RB
21 11.08 IL2RA IL2RB
22 10.98 IL2RA STAT4 TYK2
23 10.7 CD247 HLA-DRB1 IL2RA STAT4

GO Terms for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Cellular components related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 HLA-DRB1 IL2RA IL2RB

Biological processes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.62 CD247 HLA-DRB1 IL2RA PTPN22
2 T cell differentiation GO:0030217 9.4 PTPN2 PTPN22
3 negative regulation of T cell proliferation GO:0042130 9.37 HLA-DRB1 IL2RA
4 T cell receptor signaling pathway GO:0050852 9.33 CD247 HLA-DRB1 PTPN22
5 negative regulation of T cell receptor signaling pathway GO:0050860 9.26 PTPN2 PTPN22
6 inflammatory response to antigenic stimulus GO:0002437 8.96 HLA-DRB1 IL2RA
7 interleukin-2-mediated signaling pathway GO:0038110 8.62 IL2RA IL2RB

Molecular functions related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.16 CD247 PTPN22
2 interleukin-2 receptor activity GO:0004911 8.96 IL2RA IL2RB
3 interleukin-2 binding GO:0019976 8.62 IL2RA IL2RB

Sources for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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