MCID: RHM014
MIFTS: 35

Rheumatoid Vasculitis malady

Bone diseases, Cardiovascular diseases categories

Summaries for Rheumatoid Vasculitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

MalaCards: Rheumatoid Vasculitis is related to vasculitis and arthritis. An important gene associated with Rheumatoid Vasculitis is VCAM1 (vascular cell adhesion molecule 1), and among its related pathways are Cytokines and Inflammatory Response and HTLV-I infection. The compounds pge2 and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are cellular and cardiovascular system.

Aliases & Classifications for Rheumatoid Vasculitis

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42NIH Rare Diseases, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Cardiovascular diseases


Aliases & Descriptions:

rheumatoid vasculitis 42 44 60


External Ids:

ICD1025 M05.2

Related Diseases for Rheumatoid Vasculitis

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17GeneCards, 18GeneDecks
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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.5LTF, ICAM1, IL1RAPL2, VCAM1, SELE, TNF
2arthritis30.6SRF, IL1RAPL2, MIF, SELE, LTF, HLA-DRB1
3rheumatoid arthritis30.6SELE, CX3CL1, TNF, VCAM1, MIF, LTF
4myocardial infarction30.2IL1RAPL2, REN
5influenza30.0LTF
6keratitis30.0MIF
7hepatitis30.0IL1RAPL2
8glomerulonephritis30.0ICAM1, VCAM1, MIF
9hypertension30.0ICAM1, SELE, VCAM1, REN
10myositis30.0VCAM1, ICAM1, IL1RAPL2
11ankylosing spondylitis29.9TNF, IL1RAPL2, SRF
12cerebritis10.1
13myopathy10.1
14crescentic glomerulonephritis10.0
15gout10.0
16mononeuritis multiplex10.0
17cerebral amyloid angiopathy10.0
18appendicitis10.0
19herpes zoster10.0
20hepatitis a10.0
21cholecystitis10.0
22mononeuritis10.0
23spondylitis10.0
24guillain-barre syndrome10.0SRF
25kawasaki disease10.0SELE
26wegener's granulomatosis10.0SELE
27gingivitis10.0LTF
28inflammatory bowel disease10.0ICAM1
29otitis media10.0LTF
30cystic fibrosis10.0LTF
31severe pre-eclampsia10.0VCAM1
32prostatitis10.0LTF
33miller fisher syndrome10.0SRF
34pouchitis10.0LTF
35lichen planus10.0ICAM1
36bacterial vaginosis10.0LTF
37alopecia areata10.0ICAM1
38gastric ulcer10.0SRF
39atopy10.0MIF
40uremia10.0VCAM1
41prostate cancer10.0MIF
42peritonitis10.0TNF
43cervical cancer10.0LTF
44essential hypertension10.0REN
45interstitial lung disease10.0TNF
46perinatal necrotizing enterocolitis10.0LTF
47congestive heart failure10.0REN
48cholesteatoma10.0MIF
49sickle cell disease10.0SELE, VCAM1
50polyarteritis nodosa10.0LTF

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to rheumatoid vasculitis

Clinical Features for Rheumatoid Vasculitis

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Drugs & Therapeutics for Rheumatoid Vasculitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rheumatoid Vasculitis

Drug clinical trials:

Search ClinicalTrials for Rheumatoid Vasculitis

Search NIH Clinical Center for Rheumatoid Vasculitis

Search CenterWatch for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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32MalaCards
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MalaCards organs/tissues related to Rheumatoid Vasculitis:

32
Skin

Animal Models for Rheumatoid Vasculitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2TNF, MIF, CX3CL1, SRF, VCAM1, SELE
2MP:00053856.9ICAM1, TNF, REN, CX3CL1, SRF, VCAM1
3MP:00053976.5SELE, ICAM1, TNF, LTF, MIF, REN
4MP:00053876.5ICAM1, TNF, LTF, MIF, REN, CX3CL1
5MP:00053766.4ICAM1, TNF, LTF, MIF, REN, CX3CL1

Publications for Rheumatoid Vasculitis

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Genetic Variations for Rheumatoid Vasculitis

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Expression for genes affiliated with Rheumatoid Vasculitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for genes affiliated with Rheumatoid Vasculitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Rheumatoid Vasculitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1pge24410.5REN
2cyclophosphamide44 49 1112.5MIF
3rosiglitazone44 49 28 11 2414.1VCAM1
48 methoxypsoralen449.8VCAM1, SELE, ICAM1
5sele449.8VCAM1, ICAM1, SELE
6pentoxifylline44 1110.8LTF, VCAM1, IL1RAPL2
7metronidazole44 1110.8LTF, VCAM1, SELE
8ro 31-7549449.8VCAM1, TNF, SELE
9hydrocortisone44 2 59 1112.7LTF, REN
10gliclazide44 49 1111.7SELE, ICAM1, VCAM1
11celastrol44 5910.7TNF, SELE, VCAM1
12rantes449.5TNF, IL1RAPL2, ICAM1
13norepinephrine44 11 2411.4IL1RAPL2, LTF, SRF
14mycophenolic acid44 49 1111.4ICAM1, SELE, IL1RAPL2, VCAM1
15apocynin44 5910.4SELE, ICAM1, TNF, VCAM1
16groalpha449.4ICAM1, TNF, SELE, VCAM1
17gold sodium thiomalate449.4SELE, TNF, HLA-DRB1
188-isoprostane449.4SELE, TNF, VCAM1, ICAM1
19budesonide44 49 1111.4LTF, TNF, ICAM1, VCAM1
20fenofibrate44 49 1111.4SELE, VCAM1, TNF, ICAM1
21fmlp449.4ICAM1, LTF, IL1RAPL2, VCAM1
22pdtc449.3ICAM1, VCAM1, SELE, TNF
23probucol44 1110.3SELE, VCAM1, LTF
24sulfasalazine44 28 49 1112.2ICAM1, SELE, IL1RAPL2, TNF
25polymyxin b449.1SELE, ICAM1, VCAM1, LTF, TNF
26atorvastatin44 49 28 11 2413.1ICAM1, TNF, VCAM1, SELE
27cytochalasin d44 5910.1ICAM1, LTF, IL1RAPL2, VCAM1, SELE
28endotoxin449.1SELE, VCAM1, SRF, LTF, ICAM1
29homocysteine44 2410.0SELE, VCAM1, MIF, SRF
30dexamethasone44 49 28 1112.0LTF, REN, IL1RAPL2, SRF
31troglitazone44 28 59 1112.0TNF, VCAM1, SELE, ICAM1
32herbimycin a44 5910.0SELE, VCAM1, MIF, ICAM1, TNF
33n acetylcysteine449.0SELE, ICAM1, TNF, LTF, VCAM1
34isoproterenol44 119.9VCAM1, SRF, LTF, REN, SELE
35sb 20358044 599.9ICAM1, TNF, MIF, SELE, VCAM1
36simvastatin44 49 59 28 11 2413.9ICAM1, VCAM1, SELE, TNF, IL1RAPL2
37okt3448.8TNF, SRF, SELE, ICAM1, VCAM1
38prostacyclin448.7SELE, ICAM1, TNF, LTF, REN, VCAM1
39neopterin448.6IL1RAPL2, ICAM1, TNF, LTF, SRF
40actinomycin d448.5SELE, LTF, TNF, ICAM1, IL1RAPL2
41genistein44 28 59 2 11 2413.4VCAM1, SELE, SRF, MIF, TNF, ICAM1
42methotrexate44 49 1110.4HLA-DRB1, SELE, TNF, SRF, IL1RAPL2
43creatinine448.3LTF, MIF, IL1RAPL2, SRF, REN, SELE
44serine448.1SELE, TNF, SRF, IL1RAPL2, MIF, LTF
45fibrinogen448.0SRF, TNF, IL1RAPL2, LTF, SELE, ICAM1
46histamine44 28 2410.0ICAM1, IL1RAPL2, SRF, VCAM1, LTF, TNF
47lactate447.9ICAM1, TNF, IL1RAPL2, SRF, VCAM1, SELE
48retinoic acid44 248.8TNF, LTF, MIF, VCAM1, SRF, ICAM1
49nitric oxide44 11 249.5MIF, ICAM1, REN, IL1RAPL2, SRF, VCAM1
50vegf447.2LTF, TNF, ICAM1, VCAM1, MIF, REN

GO Terms for genes affiliated with Rheumatoid Vasculitis

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16Gene Ontology
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Cellular components related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6ICAM1, TNF, HLA-DRB1, VCAM1
2cell surfaceGO:0099868.5VCAM1, CX3CL1, MIF, TNF
3extracellular spaceGO:0056157.3SELE, VCAM1, CX3CL1, REN, MIF, TNF

Biological processes related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:0071599.8SELE, VCAM1, ICAM1
3heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1, SELE
4positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.8MIF, TNF
5leukocyte tethering or rollingGO:0509019.6SELE, VCAM1, TNF
6positive regulation of cytokine secretionGO:0507159.6MIF, TNF
7interferon-gamma-mediated signaling pathwayGO:0603339.5VCAM1, HLA-DRB1, ICAM1
8cell agingGO:0075699.5MIF, ICAM1
9positive regulation of NF-kappaB transcription factor activityGO:0510929.3ICAM1, TNF, LTF
10angiogenesis involved in wound healingGO:0600559.1SRF, CX3CL1
11response to hypoxiaGO:0016669.0VCAM1, SRF, TNF
12cytokine-mediated signaling pathwayGO:0192218.8VCAM1, CX3CL1, HLA-DRB1, ICAM1

Products for genes affiliated with Rheumatoid Vasculitis

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Sources for Rheumatoid Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet