MCID: RHM014
MIFTS: 40

Rheumatoid Vasculitis

Categories: Rare diseases, Cardiovascular diseases, Bone diseases

Aliases & Classifications for Rheumatoid Vasculitis

MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 49 51 69

Classifications:



External Ids:

ICD10 32 M05.2
UMLS 69 C0240903

Summaries for Rheumatoid Vasculitis

MalaCards based summary : Rheumatoid Vasculitis is related to vasculitis and glomerulonephritis. An important gene associated with Rheumatoid Vasculitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Interferon gamma signaling and Development VEGF signaling via VEGFR2 - generic cascades. Affiliated tissues include skin, liver and endothelial, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

Related Diseases for Rheumatoid Vasculitis

Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.6 CX3CL1 ICAM1 SELE TNF VCAM1
2 glomerulonephritis 29.5 ICAM1 MIF VCAM1
3 rheumatoid arthritis 29.5 HLA-DRB1 ICAM1 MIF TNF VCAM1
4 scleritis 10.5 SELE TNF
5 heterophyiasis 10.5 ICAM1 SELE
6 autoimmune myocarditis 10.5 TNF VCAM1
7 retinitis pigmentosa 60 10.5 SELE TNF
8 plummer's disease 10.4 ICAM1 SELE
9 beryllium disease 10.4 HLA-DRB1 TNF
10 microscopic polyangiitis 10.4 HLA-DRB1 TNF
11 hymenolepiasis 10.4 ICAM1 SELE
12 chronic beryllium disease 10.4 HLA-DRB1 TNF
13 autoimmune pancreatitis 10.4 HLA-DRB1 TNF
14 cortical thymoma 10.4 ICAM1 VCAM1
15 endophthalmitis 10.4 ICAM1 SELE
16 sympathetic ophthalmia 10.4 HLA-DRB1 TNF
17 poliomyelitis 10.4 ICAM1 TNF
18 immune-complex glomerulonephritis 10.4 ICAM1 VCAM1
19 nontuberculous mycobacterial lung disease 10.4 HLA-DRB1 TNF
20 hypersensitivity reaction type iii disease 10.4 ICAM1 SELE
21 microscopic colitis 10.4 HLA-DRB1 TNF
22 listeria meningitis 10.4 CX3CL1 TNF
23 central nervous system vasculitis 10.4 HLA-DRB1 TNF
24 alveolar echinococcosis 10.4 HLA-DRB1 TNF
25 pustulosis palmaris et plantaris 10.4 SELE TNF
26 limbal stem cell deficiency 10.4 ICAM1 VCAM1
27 erythema multiforme 10.3 ICAM1 TNF
28 endometritis 10.3 SELE TNF
29 hemorrhagic fever 10.3 HLA-DRB1 TNF
30 henoch-schoenlein purpura 10.3 ICAM1 VCAM1
31 pityriasis rosea 10.3 CX3CL1 HLA-DRB1
32 lichen disease 10.3 ICAM1 TNF
33 panuveitis 10.3 HLA-DRB1 TNF
34 plasmodium vivax malaria 10.3 ICAM1 SELE TNF
35 critical illness polyneuropathy 10.3 ICAM1 SELE TNF
36 cutaneous lupus erythematosus 10.3 ICAM1 SELE TNF
37 allergic contact dermatitis 10.3 ICAM1 SELE TNF
38 localized scleroderma 10.3 SELE TNF
39 contact dermatitis 10.3 ICAM1 SELE TNF
40 arteriosclerosis obliterans 10.3 ICAM1 VCAM1
41 lymphocytic vasculitis 10.2 ICAM1 SELE VCAM1
42 colon carcinoma in situ 10.2 CD44 ICAM1
43 mooren's ulcer 10.2 ICAM1 SELE VCAM1
44 primary progressive multiple sclerosis 10.2 ICAM1 TNF VCAM1
45 subendocardial myocardial infarction 10.2 ICAM1 SELE VCAM1
46 warthin tumor 10.2 CD44 VCAM1
47 leukostasis 10.2 ICAM1 SELE VCAM1
48 shwartzman phenomenon 10.2 ICAM1 SELE VCAM1
49 trypanosomiasis 10.2 ICAM1 TNF VCAM1
50 dermatitis, atopic 10.2 ICAM1 SELE TNF

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis

Symptoms & Phenotypes for Rheumatoid Vasculitis

MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 VCAM1 CD44 SELE CX3CL1 ICAM1 SRF
2 hematopoietic system MP:0005397 10.02 CD44 REN SELE CX3CL1 ICAM1 SRF
3 cardiovascular system MP:0005385 10.01 VCAM1 CD44 REN SELE CX3CL1 ICAM1
4 homeostasis/metabolism MP:0005376 9.96 CD44 REN SELE CX3CL1 ICAM1 SRF
5 immune system MP:0005387 9.85 CD44 REN SELE CX3CL1 ICAM1 SRF
6 neoplasm MP:0002006 9.35 CD44 ICAM1 LTF TNF MIF
7 normal MP:0002873 9.1 MIF REN CD44 SELE SRF LTF

Drugs & Therapeutics for Rheumatoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 JOURNEY II XR Safety and Effectiveness PMCF Recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

Anatomical Context for Rheumatoid Vasculitis

MalaCards organs/tissues related to Rheumatoid Vasculitis:

38
Skin, Liver, Endothelial, Salivary Gland, Neutrophil, Retina, Bone

Publications for Rheumatoid Vasculitis

Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 140)
# Title Authors Year
1
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. ( 28631066 )
2017
2
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? ( 28293454 )
2017
3
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. ( 28539558 )
2017
4
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. ( 28581281 )
2017
5
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. ( 27052429 )
2016
6
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. ( 27873751 )
2016
7
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. ( 27846744 )
2016
8
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. ( 26955985 )
2016
9
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. ( 27672862 )
2016
10
Refractory rheumatoid vasculitis. ( 28031844 )
2016
11
Refractory rheumatoid vasculitis-a therapeutic dilemma. ( 28031846 )
2016
12
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. ( 27041172 )
2016
13
A case of rheumatoid vasculitis. ( 27037329 )
2016
14
The dramatic effect of dapsone on cutaneous bullous and pustular rheumatoid vasculitis on the sole. ( 25865233 )
2015
15
Rheumatoid vasculitis - Case report. ( 25772654 )
2015
16
Rheumatoid vasculitis: going, going, but not yet gone. ( 25952359 )
2015
17
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. ( 26106958 )
2015
18
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna : A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. ( 26555550 )
2015
19
New insight into the rheumatoid vasculitis. ( 26402981 )
2015
20
Rheumatoid Vasculitis. ( 26278313 )
2015
21
Systemic rheumatoid vasculitis in the era of modern immunosuppressive therapy. ( 24108586 )
2014
22
Severe gangrene accompanied by varicella zoster virus-related vasculitis mimicking rheumatoid vasculitis. ( 24761143 )
2014
23
Rheumatoid arthritis: Rheumatoid vasculitis--down but not out. ( 24595091 )
2014
24
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 24533557 )
2014
25
Rheumatoid vasculitis: an update. ( 25405822 )
2014
26
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 23494445 )
2013
27
Peripheral ulcerative keratitis as the presenting feature of systemic rheumatoid vasculitis without joint involvement. ( 24234515 )
2013
28
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. ( 23557520 )
2013
29
Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab. ( 23319024 )
2013
30
Cerebral rheumatoid vasculitis: a case report. ( 22974191 )
2012
31
Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment. ( 23154729 )
2012
32
The rapid efficacy of abatacept in a patient with rheumatoid vasculitis. ( 22124545 )
2012
33
Association of HLA-DRB5*01 with protection against cutaneous manifestations of rheumatoid vasculitis in Brazilian patients. ( 22641591 )
2012
34
Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. ( 21607712 )
2012
35
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. ( 21385558 )
2011
36
Case of severe liver damage after the induction of tocilizumab therapy for rheumatoid vasculitis. ( 21435128 )
2011
37
Are anti-cyclic citrullinated peptide autoantibodies seromarkers for rheumatoid vasculitis in a cohort of patients with systemic vasculitis? ( 20107034 )
2010
38
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. ( 19639318 )
2010
39
Rheumatoid vasculitis: vanishing menace or target for new treatments? ( 20842467 )
2010
40
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. ( 19714622 )
2009
41
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. ( 19648728 )
2009
42
Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody. ( 18711097 )
2008
43
Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in two patients with rheumatoid arthritis. ( 18411212 )
2008
44
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. ( 17318275 )
2007
45
A case of rheumatoid vasculitis involving the gastrointestinal tract in early disease. ( 17908700 )
2007
46
Successful treatment of rheumatoid vasculitis-associated foot drop with rituximab. ( 16936329 )
2006
47
Systemic rheumatoid vasculitis: a review. ( 17023257 )
2006
48
Should anti-tumor necrosis factor-alpha be the first therapy for rheumatoid vasculitis? ( 16465676 )
2006
49
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. ( 17075825 )
2006
50
Rheumatoid vasculitis treated with infliximab. ( 16078342 )
2005

Variations for Rheumatoid Vasculitis

Expression for Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for Rheumatoid Vasculitis

Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 CD44 HLA-DRB1 ICAM1 VCAM1
2
Show member pathways
12.18 CD44 ICAM1 SELE VCAM1
3 12.17 HLA-DRB1 ICAM1 SRF TNF VCAM1
4 12.1 CD44 HLA-DRB1 ICAM1
5
Show member pathways
12.03 CD44 MIF SELE
6
Show member pathways
11.94 CD44 ICAM1 VCAM1
7 11.92 HLA-DRB1 ICAM1 SELE VCAM1
8 11.88 ICAM1 SELE TNF VCAM1
9 11.84 CD44 ICAM1 VCAM1
10 11.83 ICAM1 MIF TNF
11 11.8 ICAM1 TNF VCAM1
12 11.72 CD44 HLA-DRB1 TNF
13 11.7 ICAM1 TNF VCAM1
14 11.7 ICAM1 SELE TNF VCAM1
15 11.65 HLA-DRB1 ICAM1 TNF
16 11.51 ICAM1 TNF VCAM1
17 11.39 CX3CL1 ICAM1 SELE TNF VCAM1
18 11.31 ICAM1 SELE VCAM1
19 11.25 ICAM1 SELE TNF VCAM1
20 11.09 HLA-DRB1 TNF
21 11 ICAM1 SELE TNF VCAM1
22 10.94 TNF VCAM1
23
Show member pathways
10.82 ICAM1 MIF SELE TNF VCAM1
24 10.7 ICAM1 TNF VCAM1

GO Terms for Rheumatoid Vasculitis

Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CX3CL1 ICAM1 LTF MIF REN SELE
2 external side of plasma membrane GO:0009897 9.46 HLA-DRB1 ICAM1 TNF VCAM1
3 cell surface GO:0009986 9.23 CD44 CX3CL1 HLA-DRB1 ICAM1 LTF MIF

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.92 CD44 CX3CL1 ICAM1 SELE VCAM1
2 response to hypoxia GO:0001666 9.79 ICAM1 SRF VCAM1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 ICAM1 LTF TNF
4 cellular response to tumor necrosis factor GO:0071356 9.78 CX3CL1 ICAM1 VCAM1
5 extracellular matrix organization GO:0030198 9.76 CD44 ICAM1 TNF VCAM1
6 cell-matrix adhesion GO:0007160 9.74 CD44 SRF VCAM1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CD44 ICAM1 MIF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.71 CD44 MIF TNF
9 response to lipopolysaccharide GO:0032496 9.71 ICAM1 REN SELE VCAM1
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.63 CX3CL1 TNF
11 cell aging GO:0007569 9.63 ICAM1 MIF
12 positive regulation of cytokine secretion GO:0050715 9.62 MIF TNF
13 cell-cell adhesion GO:0098609 9.62 CD44 ICAM1 SRF VCAM1
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.61 ICAM1 SELE VCAM1
15 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.6 CD44 MIF
16 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.59 CD44 MIF
17 angiogenesis involved in wound healing GO:0060055 9.58 CX3CL1 SRF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 CD44 TNF
19 leukocyte migration involved in inflammatory response GO:0002523 9.56 CX3CL1 SELE
20 leukocyte cell-cell adhesion GO:0007159 9.54 ICAM1 SELE VCAM1
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.51 ICAM1 TNF
22 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.49 MIF TNF
23 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
24 interferon-gamma-mediated signaling pathway GO:0060333 9.46 CD44 HLA-DRB1 ICAM1 VCAM1
25 leukocyte tethering or rolling GO:0050901 9.43 SELE TNF VCAM1
26 leukocyte migration GO:0050900 9.35 CD44 ICAM1 MIF SELE TNF
27 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.02 CD44 CX3CL1 ICAM1 MIF TNF

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 CX3CL1 MIF TNF
2 integrin binding GO:0005178 8.8 CX3CL1 ICAM1 VCAM1

Sources for Rheumatoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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