MCID: RHM014
MIFTS: 49

Rheumatoid Vasculitis malady

Rare diseases, Bone diseases, Cardiovascular diseases categories
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Summaries for Rheumatoid Vasculitis

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Wikipedia:65 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

MalaCards based summary: Rheumatoid Vasculitis is related to vasculitis and glomerulonephritis. An important gene associated with Rheumatoid Vasculitis is SELE (selectin E), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cellular roles of Anthrax toxin. The compounds 8 methoxypsoralen and sele have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related mouse phenotypes are growth/size/body and cellular.

Aliases & Classifications for Rheumatoid Vasculitis

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS, 25ICD10
See all sources

Rheumatoid Vasculitis, Aliases & Descriptions:

Name: Rheumatoid Vasculitis 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Cardiovascular diseases


External Ids:

ICD1025 M05.2

Related Diseases for Rheumatoid Vasculitis

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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.9TNF, SELE, VCAM1, ICAM1, IL1RAPL2, LTF
2glomerulonephritis30.5MIF, ICAM1, VCAM1
3myositis30.3VCAM1, ICAM1, IL1RAPL2
4hypertension30.1SELE, VCAM1, REN, ICAM1
5ankylosing spondylitis30.0IL1RAPL2, SRF, TNF
6arthritis29.4HLA-DRB1, TNF, SELE, ICAM1, SRF, MIF
7rheumatoid arthritis28.9ICAM1, SRF, MIF, IL1RAPL2, LTF, CX3CL1
8polyarteritis nodosa10.5LTF
9acute chest syndrome10.5VCAM1
10hepatorenal syndrome10.4REN
11peripheral vascular disease10.4SELE, VCAM1
12plummer's disease10.4SELE, ICAM1
13arteriosclerosis obliterans10.4VCAM1, ICAM1
14immunoglobulin a vasculitis10.4VCAM1, ICAM1
15inclusion body myositis10.4ICAM1, VCAM1
16allergic contact dermatitis10.4SELE, ICAM1
17oral lichen planus10.3VCAM1, ICAM1
18thyroiditis10.3HLA-DRB1
19leprosy10.3HLA-DRB1
20vernal keratoconjunctivitis10.3VCAM1, ICAM1
21antiphospholipid syndrome10.3SELE, VCAM1
22blau syndrome10.3TNF
23endotheliitis10.3
24skin disease10.3HLA-DRB1
25arteriosclerosis10.3VCAM1, ICAM1
26gastrointestinal system disease10.3LTF, MIF
27leukostasis10.3SELE, VCAM1, ICAM1
28diabetic retinopathy10.2VCAM1, ICAM1, SRF
29polymyositis10.2ICAM1, VCAM1, SELE
30dermatitis10.2SELE, VCAM1, ICAM1
31allergic rhinitis10.2ICAM1, VCAM1, SELE
32rhinitis10.2ICAM1, VCAM1
33allergic asthma10.2SELE, VCAM1, ICAM1
34vascular disease10.2ICAM1, VCAM1, SELE
35acute myocardial infarction10.2SELE, SRF, MIF
36sickle cell disease10.2SELE, VCAM1
37myocardial infarction10.2
38crescentic glomerulonephritis10.2
39cerebritis10.2
40myopathy10.2
41nodular regenerative hyperplasia10.2
42foot drop10.2
43lupus nephritis10.2VCAM1, ICAM1
44coronary artery anomaly10.2SELE, VCAM1, ICAM1
45urticaria10.2SELE, IL1RAPL2
46proliferative diabetic retinopathy10.2MIF, ICAM1, VCAM1
47polymyalgia rheumatica10.2HLA-DRB1, IL1RAPL2
48hyperhomocysteinemia10.2SELE, VCAM1
49adult respiratory distress syndrome10.2TNF, SELE
50dermatomyositis10.1VCAM1, ICAM1, IL1RAPL2

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to rheumatoid vasculitis

Symptoms for Rheumatoid Vasculitis

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Drugs & Therapeutics for Rheumatoid Vasculitis

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Drug clinical trials:

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Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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MalaCards organs/tissues related to Rheumatoid Vasculitis:

32
Skin, Liver, Endothelial, Salivary gland, Bone, Retina, Neutrophil

Animal Models for Rheumatoid Vasculitis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0SRF, ICAM1, REN, VCAM1, SELE, TNF
2MP:00053847.2TNF, SELE, CX3CL1, ICAM1, SRF, MIF
3MP:00053857.1TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
4MP:00053976.6LTF, TNF, SELE, VCAM1, CX3CL1, REN
5MP:00053876.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
6MP:00053766.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1

Publications for Rheumatoid Vasculitis

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Articles related to Rheumatoid Vasculitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Rheumatoid vasculitis: an update. (25405822)
2014
2
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. (24533557)
2014
3
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. (23557520)
2013
4
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. (21385558)
2011
5
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. (19639318)
2010
6
Rheumatoid vasculitis: vanishing menace or target for new treatments? (20842467)
2010
7
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (19714622)
2009
8
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. (19648728)
2009
9
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. (17318275)
2007
10
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. (17075825)
2006
11
Successful treatment of rheumatoid vasculitis-associated foot-drop with infliximab. (15801041)
2005
12
Decrease over time in the incidence of systemic rheumatoid vasculitis: Comment on the article by Turesson et al. (15880813)
2005
13
Testicular involvement in rheumatoid vasculitis. (15675137)
2004
14
Rheumatoid vasculitis: becoming extinct? (15126674)
2004
15
Pyothorax caused by Nocardia otitidiscaviarum in a patient with rheumatoid vasculitis. (15335193)
2004
16
Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. (15529352)
2004
17
Successful treatment of severe rheumatoid vasculitis by infliximab. (12759302)
2003
18
What is your diagnosis? Bywaters lesions of rheumatoid vasculitis. (12839252)
2003
19
Myocardial infarction caused by rheumatoid vasculitis: histological evidence of the involvement of T lymphocytes. (14634788)
2003
20
Rheumatoid vasculitis associated with anticardiolipin antibodies. (10599393)
1999
21
The diagnostic value of perivascular infiltrates in muscle biopsy specimens for the assessment of rheumatoid vasculitis. (9613342)
1998
22
Rheumatoid vasculitis presenting as appendicitis. (9844770)
1998
23
Breathlessness in a patient with rheumatoid vasculitis. (9713616)
1998
24
Reduced red blood cell deformability in patients with rheumatoid vasculitis. Improvement after in vitro treatment with dipyridamole. (7848316)
1995
25
Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endothelial leucocyte adhesion molecule are increased in patients with rheumatoid vasculitis. (7540479)
1995
26
Fatal pulmonary hypertension and rheumatoid vasculitis. (7758572)
1995
27
Rheumatoid vasculitis manifesting as intra-abdominal hemorrhage. (7776717)
1995
28
Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. (7966057)
1994
29
Gout masquerading as rheumatoid vasculitis. (8182655)
1994
30
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
31
Unusual DQA-DR haplotypes in rheumatoid vasculitis. (8428242)
1993
32
Muscular involvement in systemic rheumatoid vasculitis. (8348289)
1993
33
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy. (1556686)
1992
34
Muscular involvement in systemic rheumatoid vasculitis. (1581780)
1992
35
Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis. (2259841)
1990
36
Rheumatoid vasculitis with worsening nodulosis. (2313667)
1990
37
Anti-endothelial cell antibodies in patients with rheumatoid vasculitis. (2789049)
1989
38
Acute febrile neutrophilic dermatosis (Sweet's syndrome). Association with rheumatoid vasculitis. (2757408)
1989
39
Granulomatous cutaneous rheumatoid vasculitis. (3418621)
1988
40
Rheumatoid vasculitis with intrarenal aneurysm formation. (3172098)
1988
41
Platelet releasing activity in sera of patients with rheumatoid vasculitis. (3485407)
1986
42
Rheumatoid vasculitis: survival and associated risk factors. (3784899)
1986
43
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
44
Rheumatoid vasculitis. (6678191)
1983
45
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982
46
Plasma exchange in rheumatoid vasculitis. (7288759)
1981
47
Plasma exchange in rheumatoid vasculitis. (6976658)
1981
48
Myocardial infarction caused by rheumatoid vasculitis. (7406936)
1980
49
Ankylosing spondylitis with subsequent development of rheumatoid arthritis, SjAPgren's syndrome, and rheumatoid vasculitis. (646836)
1978
50
Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. (169295)
1975

Variations for Rheumatoid Vasculitis

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Expression for genes affiliated with Rheumatoid Vasculitis

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Expression patterns in normal tissues for genes affiliated with Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for genes affiliated with Rheumatoid Vasculitis

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Pathways related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7VCAM1, TNF
39.6ICAM1, TNF
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.5ICAM1, VCAM1, SELE
59.5SELE, VCAM1, ICAM1
69.5HLA-DRB1, TNF
7
Show member pathways
9.4HLA-DRB1, VCAM1, ICAM1
8
Show member pathways
9.3SRF, TNF
99.3TNF, VCAM1, ICAM1
109.3ICAM1, VCAM1, TNF
119.2MIF, ICAM1, TNF
12
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
13
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
149.2HLA-DRB1, TNF, ICAM1
159.1HLA-DRB1, SELE, VCAM1, ICAM1
169.0ICAM1, VCAM1, SELE, TNF
179.0TNF, SELE, VCAM1, ICAM1
188.9TNF, VCAM1, ICAM1, MIF
19
Show member pathways
8.4VCAM1, CX3CL1, ICAM1, SRF
208.2HLA-DRB1, TNF, VCAM1, ICAM1, SRF
218.2ICAM1, CX3CL1, VCAM1, SELE, TNF
22
Show member pathways
8.1MIF, SRF, CX3CL1, TNF

Compounds for genes affiliated with Rheumatoid Vasculitis

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Compounds related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
18 methoxypsoralen449.8SELE, VCAM1, ICAM1
2sele449.8ICAM1, VCAM1, SELE
3metronidazole44 1110.8LTF, VCAM1, SELE
4ro 31-7549449.7VCAM1, SELE, TNF
5gliclazide44 50 1111.7ICAM1, VCAM1, SELE
6celastrol44 6110.7TNF, VCAM1, SELE
7gold sodium thiomalate449.4HLA-DRB1, SELE, TNF
8mycophenolic acid44 50 1111.4ICAM1, IL1RAPL2, VCAM1, SELE
9apocynin44 6110.4SELE, ICAM1, VCAM1, TNF
10groalpha449.4TNF, SELE, VCAM1, ICAM1
118-isoprostane449.4ICAM1, TNF, SELE, VCAM1
12budesonide44 50 1111.4VCAM1, LTF, ICAM1, TNF
13fenofibrate44 50 1111.3ICAM1, SELE, VCAM1, TNF
14pdtc449.3ICAM1, VCAM1, TNF, SELE
15sulfasalazine28 44 50 1112.2IL1RAPL2, TNF, SELE, ICAM1
16polymyxin b449.1LTF, ICAM1, VCAM1, SELE, TNF
17cytochalasin d44 6110.1SELE, LTF, VCAM1, IL1RAPL2, ICAM1
18cyclophosphamide44 50 1111.0LTF, IL1RAPL2, MIF, VCAM1, SELE
19herbimycin a44 6110.0MIF, TNF, SELE, VCAM1, ICAM1
20atorvastatin44 50 28 24 1113.0TNF, ICAM1, VCAM1, SELE
21troglitazone44 28 61 1112.0TNF, VCAM1, ICAM1, SELE
22homocysteine44 2410.0VCAM1, MIF, SRF, SELE
23n acetylcysteine449.0LTF, ICAM1, SELE, TNF, VCAM1
24sb 20358044 619.9SELE, TNF, ICAM1, MIF, VCAM1
25isoproterenol44 119.9LTF, SRF, SELE, VCAM1, REN
26pentoxifylline44 119.9VCAM1, ICAM1, IL1RAPL2, LTF, TNF
27simvastatin44 50 61 28 24 1113.9IL1RAPL2, ICAM1, VCAM1, SELE, TNF
28okt3448.8TNF, SELE, VCAM1, ICAM1, SRF
29fmlp448.8IL1RAPL2, LTF, ICAM1, VCAM1, TNF
30hydrocortisone44 2 61 1111.8REN, TNF, MIF, LTF
31prostacyclin448.7REN, ICAM1, TNF, LTF, VCAM1, SELE
32actinomycin d448.7SELE, ICAM1, IL1RAPL2, LTF, TNF
33neopterin448.6IL1RAPL2, SRF, ICAM1, LTF, TNF
34rosiglitazone28 44 50 24 1112.5IL1RAPL2, VCAM1, SELE, TNF
35rantes448.5SELE, IL1RAPL2, MIF, ICAM1, TNF, VCAM1
36genistein44 28 61 2 24 1113.4ICAM1, SELE, TNF, MIF, SRF, VCAM1
37methotrexate50 44 1110.4SRF, SELE, TNF, HLA-DRB1, IL1RAPL2
38creatinine448.3SELE, IL1RAPL2, REN, SRF, MIF, LTF
39alanine448.2HLA-DRB1, SELE, VCAM1, SRF, MIF, LTF
40norepinephrine44 24 1110.1MIF, LTF, IL1RAPL2, SRF, REN, VCAM1
41fibrinogen448.0SELE, IL1RAPL2, TNF, VCAM1, ICAM1, SRF
42histamine44 28 2410.0IL1RAPL2, TNF, SELE, VCAM1, ICAM1, SRF
43lactate447.9MIF, TNF, SELE, VCAM1, IL1RAPL2, ICAM1
44retinoic acid44 248.8ICAM1, TNF, VCAM1, MIF, SRF, IL1RAPL2
45endotoxin447.6VCAM1, ICAM1, SRF, MIF, IL1RAPL2, LTF
46nitric oxide44 24 119.5SELE, MIF, IL1RAPL2, TNF, SRF, ICAM1
47dexamethasone44 50 28 1110.5IL1RAPL2, REN, LTF, MIF, SRF, TNF
48pge2447.2VCAM1, TNF, SELE, REN, ICAM1, SRF
49vegf447.2VCAM1, SELE, ICAM1, LTF, SRF, MIF
50serine447.1SRF, IL1RAPL2, CX3CL1, LTF, MIF, VCAM1

GO Terms for genes affiliated with Rheumatoid Vasculitis

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Cellular components related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF, HLA-DRB1
2cell surfaceGO:0099868.4TNF, VCAM1, CX3CL1, MIF
3extracellular regionGO:0055768.0LTF, MIF, REN, CX3CL1, TNF
4extracellular spaceGO:0056157.2LTF, TNF, SELE, VCAM1, CX3CL1, REN
5plasma membraneGO:0058867.0HLA-DRB1, TNF, SELE, VCAM1, CX3CL1, REN

Biological processes related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1ICAM1, VCAM1
2cell agingGO:00756910.0ICAM1, MIF
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.9MIF, TNF
4leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1, SELE
5heterophilic cell-cell adhesionGO:0071579.9SELE, VCAM1, ICAM1
6positive regulation of cytokine secretionGO:0507159.8TNF, MIF
7positive regulation of nitric oxide biosynthetic processGO:0454299.8ICAM1, TNF
8calcium-mediated signalingGO:0197229.8SELE, TNF
9response to lipopolysaccharideGO:0324969.8SELE, VCAM1, REN
10response to ionizing radiationGO:0102129.7VCAM1, ICAM1
11leukocyte tethering or rollingGO:0509019.7TNF, SELE, VCAM1
12interferon-gamma-mediated signaling pathwayGO:0603339.7HLA-DRB1, VCAM1, ICAM1
13positive regulation of MAP kinase activityGO:0434069.6MIF, TNF
14positive regulation of NF-kappaB transcription factor activityGO:0510929.5LTF, ICAM1, TNF
15cellular response to glucose stimulusGO:0713339.5SRF, ICAM1, VCAM1
16regulation of cell adhesionGO:0301559.5ICAM1, SRF
17inflammatory responseGO:0069549.4MIF, SELE, TNF
18angiogenesis involved in wound healingGO:0600559.3SRF, CX3CL1
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3TNF, CX3CL1
20response to hypoxiaGO:0016669.3SRF, VCAM1, TNF
21extracellular matrix organizationGO:0301989.0ICAM1, VCAM1, TNF
22cytokine-mediated signaling pathwayGO:0192218.4IL1RAPL2, ICAM1, CX3CL1, VCAM1, HLA-DRB1

Molecular functions related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.9MIF, REN, CX3CL1

Products for genes affiliated with Rheumatoid Vasculitis

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  • Antibodies
  • Proteins
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Sources for Rheumatoid Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet