MCID: RHM014
MIFTS: 41

Rheumatoid Vasculitis malady

Rare diseases, Bone diseases, Cardiovascular diseases categories

Aliases & Classifications for Rheumatoid Vasculitis

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS, 25ICD10
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Rheumatoid Vasculitis, Aliases & Descriptions:

Name: Rheumatoid Vasculitis 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Cardiovascular diseases


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ICD1025 M05.2

Summaries for Rheumatoid Vasculitis

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Wikipedia:63 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

MalaCards based summary: Rheumatoid Vasculitis is related to vasculitis and glomerulonephritis. An important gene associated with Rheumatoid Vasculitis is SELE (selectin E), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cellular roles of Anthrax toxin. The compounds 8 methoxypsoralen and sele have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related mouse phenotypes are growth/size/body and cellular.

Related Diseases for Rheumatoid Vasculitis

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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.9TNF, SELE, VCAM1, ICAM1, IL1RAPL2, LTF
2glomerulonephritis30.5MIF, ICAM1, VCAM1
3myositis30.3VCAM1, ICAM1, IL1RAPL2
4arthritis29.4HLA-DRB1, TNF, SELE, ICAM1, SRF, MIF
5rheumatoid arthritis28.9ICAM1, SRF, MIF, IL1RAPL2, LTF, CX3CL1
6polyarteritis nodosa10.5LTF
7acute chest syndrome10.5VCAM1
8hepatorenal syndrome10.4REN
9allergic rhinitis10.4VCAM1, SELE
10peripheral vascular disease10.4SELE, VCAM1
11plummer's disease10.4SELE, ICAM1
12arteriosclerosis obliterans10.4VCAM1, ICAM1
13henoch-schoenlein purpura10.4VCAM1, ICAM1
14inclusion body myositis10.4ICAM1, VCAM1
15allergic contact dermatitis10.3SELE, ICAM1
16oral lichen planus10.3VCAM1, ICAM1
17thyroiditis10.3HLA-DRB1
18leprosy10.3HLA-DRB1
19vernal keratoconjunctivitis10.3VCAM1, ICAM1
20antiphospholipid syndrome10.3SELE, VCAM1
21blau syndrome10.3TNF
22endotheliitis10.3
23skin disease10.3HLA-DRB1
24arteriosclerosis10.3VCAM1, ICAM1
25gastrointestinal system disease10.3LTF, MIF
26leukostasis10.2SELE, VCAM1, ICAM1
27microvascular complications of diabetes 510.2VCAM1, ICAM1, SRF
28polymyositis10.2ICAM1, VCAM1, SELE
29dermatitis10.2SELE, VCAM1, ICAM1
30rhinitis10.2ICAM1, VCAM1
31allergic asthma10.2SELE, VCAM1, ICAM1
32myocardial infarction10.2
33cerebritis10.2
34crescentic glomerulonephritis10.2
35myopathy10.2
36nodular regenerative hyperplasia10.2
37foot drop10.2
38vascular disease10.2ICAM1, VCAM1, SELE
39acute myocardial infarction10.2SELE, SRF, MIF
40sickle cell disease10.2SELE, VCAM1
41lupus nephritis10.2VCAM1, ICAM1
42coronary artery disease10.2SELE, VCAM1, ICAM1
43urticaria10.2SELE, IL1RAPL2
44microvascular complications of diabetes 110.2MIF, ICAM1, VCAM1
45polymyalgia rheumatica10.2HLA-DRB1, IL1RAPL2
46hyperhomocysteinemia10.1SELE, VCAM1
47acute respiratory distress syndrome10.1TNF, SELE
48dermatomyositis10.1VCAM1, ICAM1, IL1RAPL2
49chorioamnionitis10.1TNF, LTF
50chronic kidney failure10.1LTF, SRF, REN

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to rheumatoid vasculitis

Symptoms for Rheumatoid Vasculitis

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Drugs & Therapeutics for Rheumatoid Vasculitis

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Drug clinical trials:

Search ClinicalTrials for Rheumatoid Vasculitis

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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MalaCards organs/tissues related to Rheumatoid Vasculitis:

31
Skin, Liver, Endothelial, Salivary gland, Bone, Retina, Neutrophil

Animal Models for Rheumatoid Vasculitis or affiliated genes

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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0SRF, ICAM1, REN, VCAM1, SELE, TNF
2MP:00053847.2TNF, SELE, CX3CL1, ICAM1, SRF, MIF
3MP:00053857.1TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
4MP:00053976.6LTF, TNF, SELE, VCAM1, CX3CL1, REN
5MP:00053876.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
6MP:00053766.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1

Publications for Rheumatoid Vasculitis

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Articles related to Rheumatoid Vasculitis:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Rheumatoid vasculitis: an update. (25405822)
2014
2
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. (24533557)
2014
3
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. (23557520)
2013
4
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. (21385558)
2011
5
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. (19639318)
2010
6
Rheumatoid vasculitis: vanishing menace or target for new treatments? (20842467)
2010
7
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (19714622)
2009
8
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. (19648728)
2009
9
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. (17318275)
2007
10
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. (17075825)
2006
11
Successful treatment of rheumatoid vasculitis-associated foot-drop with infliximab. (15801041)
2005
12
Decrease over time in the incidence of systemic rheumatoid vasculitis: Comment on the article by Turesson et al. (15880813)
2005
13
Testicular involvement in rheumatoid vasculitis. (15675137)
2004
14
Rheumatoid vasculitis: becoming extinct? (15126674)
2004
15
Pyothorax caused by Nocardia otitidiscaviarum in a patient with rheumatoid vasculitis. (15335193)
2004
16
Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. (15529352)
2004
17
Successful treatment of severe rheumatoid vasculitis by infliximab. (12759302)
2003
18
What is your diagnosis? Bywaters lesions of rheumatoid vasculitis. (12839252)
2003
19
Myocardial infarction caused by rheumatoid vasculitis: histological evidence of the involvement of T lymphocytes. (14634788)
2003
20
Rheumatoid vasculitis associated with anticardiolipin antibodies. (10599393)
1999
21
The diagnostic value of perivascular infiltrates in muscle biopsy specimens for the assessment of rheumatoid vasculitis. (9613342)
1998
22
Rheumatoid vasculitis presenting as appendicitis. (9844770)
1998
23
Breathlessness in a patient with rheumatoid vasculitis. (9713616)
1998
24
Reduced red blood cell deformability in patients with rheumatoid vasculitis. Improvement after in vitro treatment with dipyridamole. (7848316)
1995
25
Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endothelial leucocyte adhesion molecule are increased in patients with rheumatoid vasculitis. (7540479)
1995
26
Fatal pulmonary hypertension and rheumatoid vasculitis. (7758572)
1995
27
Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. (7966057)
1994
28
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
29
Unusual DQA-DR haplotypes in rheumatoid vasculitis. (8428242)
1993
30
Muscular involvement in systemic rheumatoid vasculitis. (8348289)
1993
31
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy. (1556686)
1992
32
Muscular involvement in systemic rheumatoid vasculitis. (1581780)
1992
33
Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis. (2259841)
1990
34
Rheumatoid vasculitis with worsening nodulosis. (2313667)
1990
35
Anti-endothelial cell antibodies in patients with rheumatoid vasculitis. (2789049)
1989
36
Acute febrile neutrophilic dermatosis (Sweet's syndrome). Association with rheumatoid vasculitis. (2757408)
1989
37
Granulomatous cutaneous rheumatoid vasculitis. (3418621)
1988
38
Rheumatoid vasculitis with intrarenal aneurysm formation. (3172098)
1988
39
Platelet releasing activity in sera of patients with rheumatoid vasculitis. (3485407)
1986
40
Rheumatoid vasculitis: survival and associated risk factors. (3784899)
1986
41
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
42
Rheumatoid vasculitis: diagnostic and therapeutic decisions. (6678193)
1983
43
Rheumatoid vasculitis. (6678191)
1983
44
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982
45
Plasma exchange in rheumatoid vasculitis. (7288759)
1981
46
Plasma exchange in rheumatoid vasculitis. (6976658)
1981
47
Rheumatoid vasculitis. (7309308)
1981
48
Myocardial infarction caused by rheumatoid vasculitis. (7406936)
1980
49
Ankylosing spondylitis with subsequent development of rheumatoid arthritis, SjAPgren's syndrome, and rheumatoid vasculitis. (646836)
1978
50
Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. (169295)
1975

Variations for Rheumatoid Vasculitis

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Expression for genes affiliated with Rheumatoid Vasculitis

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Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for genes affiliated with Rheumatoid Vasculitis

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Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7VCAM1, TNF
39.6ICAM1, TNF
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.5ICAM1, VCAM1, SELE
59.5SELE, VCAM1, ICAM1
69.5HLA-DRB1, TNF
7
Show member pathways
9.4HLA-DRB1, VCAM1, ICAM1
8
Show member pathways
9.3SRF, TNF
99.3TNF, VCAM1, ICAM1
109.3ICAM1, VCAM1, TNF
119.2MIF, ICAM1, TNF
12
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
13
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
149.2HLA-DRB1, TNF, ICAM1
159.1HLA-DRB1, SELE, VCAM1, ICAM1
169.0ICAM1, VCAM1, SELE, TNF
179.0TNF, SELE, VCAM1, ICAM1
188.9TNF, VCAM1, ICAM1, MIF
19
Show member pathways
8.4VCAM1, CX3CL1, ICAM1, SRF
208.2HLA-DRB1, TNF, VCAM1, ICAM1, SRF
218.2ICAM1, CX3CL1, VCAM1, SELE, TNF
22
Show member pathways
8.1MIF, SRF, CX3CL1, TNF

Compounds for genes affiliated with Rheumatoid Vasculitis

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Compounds related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
18 methoxypsoralen439.8SELE, VCAM1, ICAM1
2sele439.8ICAM1, VCAM1, SELE
3metronidazole43 1210.8LTF, VCAM1, SELE
4ro 31-7549439.7VCAM1, SELE, TNF
5gliclazide43 49 1211.7ICAM1, VCAM1, SELE
6celastrol43 5910.7TNF, VCAM1, SELE
7gold sodium thiomalate439.4HLA-DRB1, SELE, TNF
8mycophenolic acid43 49 1211.4ICAM1, IL1RAPL2, VCAM1, SELE
9apocynin43 5910.4SELE, ICAM1, VCAM1, TNF
10groalpha439.4TNF, SELE, VCAM1, ICAM1
118-isoprostane439.4ICAM1, TNF, SELE, VCAM1
12budesonide43 49 1211.4VCAM1, LTF, ICAM1, TNF
13fenofibrate43 49 1211.3ICAM1, SELE, VCAM1, TNF
14pdtc439.3ICAM1, VCAM1, TNF, SELE
15sulfasalazine28 43 49 1212.2IL1RAPL2, TNF, SELE, ICAM1
16polymyxin b439.1LTF, ICAM1, VCAM1, SELE, TNF
17cytochalasin d43 5910.1SELE, LTF, VCAM1, IL1RAPL2, ICAM1
18cyclophosphamide43 49 1211.0LTF, IL1RAPL2, MIF, VCAM1, SELE
19herbimycin a43 5910.0MIF, TNF, SELE, VCAM1, ICAM1
20atorvastatin43 49 28 24 1213.0TNF, ICAM1, VCAM1, SELE
21troglitazone43 28 59 1212.0TNF, VCAM1, ICAM1, SELE
22homocysteine43 2410.0VCAM1, MIF, SRF, SELE
23n acetylcysteine439.0LTF, ICAM1, SELE, TNF, VCAM1
24sb 20358043 599.9SELE, TNF, ICAM1, MIF, VCAM1
25isoproterenol43 129.9LTF, SRF, SELE, VCAM1, REN
26pentoxifylline43 129.9VCAM1, ICAM1, IL1RAPL2, LTF, TNF
27simvastatin43 49 59 28 24 1213.9IL1RAPL2, ICAM1, VCAM1, SELE, TNF
28okt3438.8TNF, SELE, VCAM1, ICAM1, SRF
29fmlp438.8IL1RAPL2, LTF, ICAM1, VCAM1, TNF
30hydrocortisone43 2 59 1211.8REN, TNF, MIF, LTF
31prostacyclin438.7REN, ICAM1, TNF, LTF, VCAM1, SELE
32actinomycin d438.7SELE, ICAM1, IL1RAPL2, LTF, TNF
33neopterin438.6IL1RAPL2, SRF, ICAM1, LTF, TNF
34rosiglitazone28 43 49 24 1212.5IL1RAPL2, VCAM1, SELE, TNF
35rantes438.5SELE, IL1RAPL2, MIF, ICAM1, TNF, VCAM1
36genistein43 28 59 2 24 1213.4ICAM1, SELE, TNF, MIF, SRF, VCAM1
37methotrexate49 43 1210.4SRF, SELE, TNF, HLA-DRB1, IL1RAPL2
38creatinine438.3SELE, IL1RAPL2, REN, SRF, MIF, LTF
39alanine438.2HLA-DRB1, SELE, VCAM1, SRF, MIF, LTF
40norepinephrine43 24 1210.1MIF, LTF, IL1RAPL2, SRF, REN, VCAM1
41fibrinogen438.0SELE, IL1RAPL2, TNF, VCAM1, ICAM1, SRF
42histamine43 28 2410.0IL1RAPL2, TNF, SELE, VCAM1, ICAM1, SRF
43lactate437.9MIF, TNF, SELE, VCAM1, IL1RAPL2, ICAM1
44retinoic acid43 248.8ICAM1, TNF, VCAM1, MIF, SRF, IL1RAPL2
45endotoxin437.6VCAM1, ICAM1, SRF, MIF, IL1RAPL2, LTF
46nitric oxide43 24 129.5SELE, MIF, IL1RAPL2, TNF, SRF, ICAM1
47dexamethasone43 49 28 1210.5IL1RAPL2, REN, LTF, MIF, SRF, TNF
48pge2437.2VCAM1, TNF, SELE, REN, ICAM1, SRF
49vegf437.2VCAM1, SELE, ICAM1, LTF, SRF, MIF
50serine437.1SRF, IL1RAPL2, CX3CL1, LTF, MIF, VCAM1

GO Terms for genes affiliated with Rheumatoid Vasculitis

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Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9ICAM1, VCAM1, TNF, HLA-DRB1
2cell surfaceGO:00099868.4TNF, VCAM1, CX3CL1, MIF
3extracellular regionGO:00055768.0LTF, MIF, REN, CX3CL1, TNF
4extracellular spaceGO:00056157.2LTF, TNF, SELE, VCAM1, CX3CL1, REN
5plasma membraneGO:00058867.0HLA-DRB1, TNF, SELE, VCAM1, CX3CL1, REN

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.1ICAM1, VCAM1
2cell agingGO:000756910.0ICAM1, MIF
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:020003439.9MIF, TNF
4leukocyte cell-cell adhesionGO:00071599.9ICAM1, VCAM1, SELE
5heterophilic cell-cell adhesionGO:00071579.9SELE, VCAM1, ICAM1
6positive regulation of cytokine secretionGO:00507159.8TNF, MIF
7positive regulation of nitric oxide biosynthetic processGO:00454299.8ICAM1, TNF
8calcium-mediated signalingGO:00197229.8SELE, TNF
9response to lipopolysaccharideGO:00324969.8SELE, VCAM1, REN
10response to ionizing radiationGO:00102129.7VCAM1, ICAM1
11leukocyte tethering or rollingGO:00509019.7TNF, SELE, VCAM1
12interferon-gamma-mediated signaling pathwayGO:00603339.7HLA-DRB1, VCAM1, ICAM1
13positive regulation of MAP kinase activityGO:00434069.6MIF, TNF
14positive regulation of NF-kappaB transcription factor activityGO:00510929.5LTF, ICAM1, TNF
15cellular response to glucose stimulusGO:00713339.5SRF, ICAM1, VCAM1
16regulation of cell adhesionGO:00301559.5ICAM1, SRF
17inflammatory responseGO:00069549.4MIF, SELE, TNF
18angiogenesis involved in wound healingGO:00600559.3SRF, CX3CL1
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.3TNF, CX3CL1
20response to hypoxiaGO:00016669.3SRF, VCAM1, TNF
21extracellular matrix organizationGO:00301989.0ICAM1, VCAM1, TNF
22cytokine-mediated signaling pathwayGO:00192218.4IL1RAPL2, ICAM1, CX3CL1, VCAM1, HLA-DRB1

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051028.9MIF, REN, CX3CL1

Products for genes affiliated with Rheumatoid Vasculitis

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Sources for Rheumatoid Vasculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet