MCID: RHM014
MIFTS: 41

Rheumatoid Vasculitis malady

Bone, Cardiovascular categories

Summaries for Rheumatoid Vasculitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

MalaCards: Rheumatoid Vasculitis is related to vasculitis and arthritis. An important gene associated with Rheumatoid Vasculitis is VCAM1 (vascular cell adhesion molecule 1), and among its related pathways are Cytokines and Inflammatory Response and HTLV-I infection. The compounds pge2 and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include retina, skeletal muscle and liver, and related mouse phenotypes are cellular and cardiovascular system.

Aliases & Classifications for Rheumatoid Vasculitis

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone, Cardiovascular


Aliases & Descriptions:

rheumatoid vasculitis 43 45 61


External Ids:

ICD1025 M05.2

Related Diseases for Rheumatoid Vasculitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.5SELE, VCAM1, IL1RAPL2, LTF, TNF, ICAM1
2arthritis30.6ICAM1, TNF, HLA-DRB1, LTF, MIF, IL1RAPL2
3ankylosing spondylitis30.0TNF, IL1RAPL2, SRF
4nodular regenerative hyperplasia10.2
5foot drop10.2
6crescentic glomerulonephritis10.0
7gout10.0
8mononeuritis multiplex10.0
9cerebral amyloid angiopathy10.0
10appendicitis10.0
11herpes zoster10.0
12n syndrome10.0
13spondylitis10.0
14acute febrile neutrophilic dermatosis10.0
15rheumatoid nodulosis10.0
16guillain-barre syndrome10.0SRF
17kawasaki disease10.0SELE
18wegener's granulomatosis10.0SELE
19gingivitis10.0LTF
20inflammatory bowel disease10.0ICAM1
21otitis media10.0LTF
22cystic fibrosis10.0LTF
23severe pre-eclampsia10.0VCAM1
24prostatitis10.0LTF
25miller fisher syndrome10.0SRF
26pouchitis10.0LTF
27lichen planus10.0ICAM1
28bacterial vaginosis10.0LTF
29alopecia areata10.0ICAM1
30gastric ulcer10.0SRF
31influenza10.0LTF
32atopy10.0MIF
33uremia10.0VCAM1
34prostate cancer10.0MIF
35peritonitis10.0TNF
36keratitis10.0MIF
37cervical cancer10.0LTF
38essential hypertension10.0REN
39interstitial lung disease10.0TNF
40perinatal necrotizing enterocolitis10.0LTF
41congestive heart failure10.0REN
42cholesteatoma10.0MIF
43sickle cell disease10.0SELE, VCAM1
44eosinophilia10.0VCAM1, SRF
45thyroiditis10.0HLA-DRB1
46adrenoleukodystrophy10.0REN
47rhinitis10.0VCAM1, ICAM1
48antiphospholipid syndrome10.0VCAM1, SELE
49hyperglycemia10.0SELE, VCAM1
50hypertriglyceridemia10.0SELE, VCAM1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to rheumatoid vasculitis

Clinical Features for Rheumatoid Vasculitis

Drugs & Therapeutics for Rheumatoid Vasculitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rheumatoid Vasculitis

Drug clinical trials:

Search ClinicalTrials for Rheumatoid Vasculitis

Search NIH Clinical Center for Rheumatoid Vasculitis

Search CenterWatch for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

Anatomical Context for Rheumatoid Vasculitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Rheumatoid Vasculitis:

33
Retina, Skeletal muscle, Liver, Lung, Salivary gland, Skin, T cells, Endothelial

Animal Models for Rheumatoid Vasculitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2VCAM1, SRF, CX3CL1, MIF, TNF, ICAM1
2MP:00053856.9VCAM1, SRF, CX3CL1, REN, TNF, ICAM1
3MP:00053976.5REN, MIF, LTF, TNF, ICAM1, SRF
4MP:00053876.5MIF, CX3CL1, TNF, ICAM1, SRF, REN
5MP:00053766.4SELE, VCAM1, SRF, REN, MIF, LTF

Publications for Rheumatoid Vasculitis

Sources:
51PubMed
See all sources

Articles related to Rheumatoid Vasculitis:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Anti-CCP antibody in a patient with generalized discoid lupus erythematosus, vasculitis and acute interstitial lung disease but not rheumatoid arthritis. (24171815)
2013
2
Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab. (23319024)
2013
3
The rapid efficacy of abatacept in a patient with rheumatoid vasculitis. (22124545)
2012
4
Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. (21607712)
2012
5
Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment. (23154729)
2012
6
Cerebral rheumatoid vasculitis: a case report. (22974191)
2012
7
Case of rheumatoid papules: is this a link between vasculitis and rheumatoid nodules? (23181622)
2012
8
Case of severe liver damage after the induction of tocilizumab therapy for rheumatoid vasculitis. (21435128)
2011
9
Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in two patients with rheumatoid arthritis. (18411212)
2008
10
C-ANCA positive systemic vasculitis in a patient with rheumatoid arthritis treated with infliximab. (17712519)
2008
11
Cerebral vasculitis in a patient with rheumatoid arthritis. (17336121)
2007
12
A case of rheumatoid vasculitis involving the gastrointestinal tract in early disease. (17908700)
2007
13
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. (17075825)
2006
14
Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. (16947780)
2006
15
Clinically diagnosed fatal cerebral vasculitis in long-standing juvenile rheumatoid arthritis. (16328354)
2006
16
Rheumatoid arthritis complicated with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: a case report. (17029047)
2005
17
Rheumatoid vasculitis treated with infliximab. (16078342)
2005
18
Testicular involvement in rheumatoid vasculitis. (15675137)
2004
19
Rheumatoid vasculitis: becoming extinct? (15126674)
2004
20
Successful treatment of severe rheumatoid vasculitis by infliximab. (12759302)
2003
21
Diagnostic strategy for the assessment of rheumatoid vasculitis. (12695150)
2003
22
Effect of immune complexes in serum from patients with rheumatoid vasculitis on the expression of cell adhesion molecules on polymorphonuclear cells. (11247327)
2001
23
The diagnostic value of perivascular infiltrates in muscle biopsy specimens for the assessment of rheumatoid vasculitis. (9613342)
1998
24
A case with rheumatoid arthritis complicated with ANCA-associated vasculitis]. (9852752)
1998
25
A 15-year exercise program for rheumatoid vasculitis. (9572643)
1998
26
ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. (9059140)
1997
27
Cutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: a possible manifestation of methotrexate hypersensitivity. (9456017)
1997
28
Circulating intercellular adhesion molecule 1 in rheumatoid arthritis--relationship to systemic vasculitis and microvascular injury in nailfold capillary microscopy. (8853170)
1996
29
Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endothelial leucocyte adhesion molecule are increased in patients with rheumatoid vasculitis. (7540479)
1995
30
Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia. (7574826)
1995
31
Fatal pulmonary hypertension and rheumatoid vasculitis. (7758572)
1995
32
Reactivation of rheumatoid arthritis and development of leukocytoclastic vasculitis in a patient receiving granulocyte colony-stimulating factor for Felty's syndrome. (7539978)
1995
33
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
34
Abnormal plasma fibrinolysis in patients with rheumatoid arthritis and impaired endothelial fibrinolytic response in those complicated by vasculitis. (8239758)
1993
35
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy. (1556686)
1992
36
Retinal vasculitis in rheumatoid arthritis: an angiographic study. (2338009)
1990
37
Retinal vasculitis as a complication of rheumatoid arthritis. (2077456)
1990
38
Acute febrile neutrophilic dermatosis (Sweet's syndrome). Association with rheumatoid vasculitis. (2757408)
1989
39
Patterns of antihistone antibody specificity in systemic rheumatic disease. I Systemic lupus erythematosus, mixed connective tissue disease, primary sicca syndrome, and rheumatoid arthritis with vasculitis. (3872129)
1985
40
Rheumatoid vasculitis. (6678191)
1983
41
Avascular necrosis of bone with rheumatoid vasculitis. (6864680)
1983
42
IgG rheumatoid factors and anti-nuclear antibodies in rheumatoid vasculitis. (6602676)
1983
43
Plasma exchange in rheumatoid vasculitis. (6976658)
1981
44
Rheumatoid vasculitis. (7309308)
1981
45
Smoking and rheumatoid vasculitis. (7346969)
1981
46
Cutaneous rheumatoid vasculitis. (38216)
1979
47
Central nervous system vasculitis in rheumatoid arthritis. (597801)
1977
48
Rheumatoid vasculitis. (9097)
1976
49
Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. (169295)
1975
50
Proceedings: Controlled trial of azathioprine in rheumatoid vasculitis. (4586509)
1973

Genetic Variations for Rheumatoid Vasculitis

Expression for genes affiliated with Rheumatoid Vasculitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for genes affiliated with Rheumatoid Vasculitis

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Rheumatoid Vasculitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1pge24510.5REN
2cyclophosphamide45 50 1112.5MIF
3rosiglitazone45 50 29 11 2414.1VCAM1
48 methoxypsoralen459.8VCAM1, SELE, ICAM1
5sele459.8VCAM1, ICAM1, SELE
6pentoxifylline45 1110.8LTF, VCAM1, IL1RAPL2
7metronidazole45 1110.8LTF, VCAM1, SELE
8ro 31-7549459.8VCAM1, TNF, SELE
9hydrocortisone45 2 60 1112.7LTF, REN
10gliclazide45 50 1111.7SELE, ICAM1, VCAM1
11celastrol45 6010.7TNF, SELE, VCAM1
12rantes459.5TNF, IL1RAPL2, ICAM1
13norepinephrine45 11 2411.4IL1RAPL2, LTF, SRF
14mycophenolic acid45 50 1111.4ICAM1, SELE, IL1RAPL2, VCAM1
15apocynin45 6010.4SELE, ICAM1, TNF, VCAM1
16groalpha459.4ICAM1, TNF, SELE, VCAM1
17gold sodium thiomalate459.4SELE, TNF, HLA-DRB1
188-isoprostane459.4SELE, TNF, VCAM1, ICAM1
19budesonide45 50 1111.4LTF, TNF, ICAM1, VCAM1
20fenofibrate45 50 1111.4SELE, VCAM1, TNF, ICAM1
21fmlp459.4ICAM1, LTF, IL1RAPL2, VCAM1
22pdtc459.3ICAM1, VCAM1, SELE, TNF
23probucol45 1110.3SELE, VCAM1, LTF
24sulfasalazine45 29 50 1112.2ICAM1, SELE, IL1RAPL2, TNF
25polymyxin b459.1SELE, ICAM1, VCAM1, LTF, TNF
26atorvastatin45 50 29 11 2413.1ICAM1, TNF, VCAM1, SELE
27cytochalasin d45 6010.1ICAM1, LTF, IL1RAPL2, VCAM1, SELE
28endotoxin459.1SELE, VCAM1, SRF, LTF, ICAM1
29homocysteine45 2410.0SELE, VCAM1, MIF, SRF
30dexamethasone45 50 29 1112.0LTF, REN, IL1RAPL2, SRF
31troglitazone45 29 60 1112.0TNF, VCAM1, SELE, ICAM1
32herbimycin a45 6010.0SELE, VCAM1, MIF, ICAM1, TNF
33n acetylcysteine459.0SELE, ICAM1, TNF, LTF, VCAM1
34isoproterenol45 119.9VCAM1, SRF, LTF, REN, SELE
35sb 20358045 609.9ICAM1, TNF, MIF, SELE, VCAM1
36simvastatin45 50 60 29 11 2413.9ICAM1, VCAM1, SELE, TNF, IL1RAPL2
37okt3458.8TNF, SRF, SELE, ICAM1, VCAM1
38prostacyclin458.7SELE, ICAM1, TNF, LTF, REN, VCAM1
39neopterin458.6IL1RAPL2, ICAM1, TNF, LTF, SRF
40actinomycin d458.5SELE, LTF, TNF, ICAM1, IL1RAPL2
41genistein45 29 60 2 11 2413.4VCAM1, SELE, SRF, MIF, TNF, ICAM1
42methotrexate45 50 1110.4HLA-DRB1, SELE, TNF, SRF, IL1RAPL2
43creatinine458.3LTF, MIF, IL1RAPL2, SRF, REN, SELE
44serine458.1SELE, TNF, SRF, IL1RAPL2, MIF, LTF
45fibrinogen458.0SRF, TNF, IL1RAPL2, LTF, SELE, ICAM1
46histamine45 29 2410.0ICAM1, IL1RAPL2, SRF, VCAM1, LTF, TNF
47lactate457.9ICAM1, TNF, IL1RAPL2, SRF, VCAM1, SELE
48retinoic acid45 248.8TNF, LTF, MIF, VCAM1, SRF, ICAM1
49nitric oxide45 11 249.5MIF, ICAM1, REN, IL1RAPL2, SRF, VCAM1
50vegf457.2LTF, TNF, ICAM1, VCAM1, MIF, REN

GO Terms for genes affiliated with Rheumatoid Vasculitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6ICAM1, TNF, HLA-DRB1, VCAM1
2cell surfaceGO:0099868.5VCAM1, CX3CL1, MIF, TNF
3extracellular spaceGO:0056157.3SELE, VCAM1, CX3CL1, REN, MIF, TNF

Biological processes related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:0071599.8ICAM1, VCAM1, SELE
3heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1, SELE
4positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.8TNF, MIF
5leukocyte tethering or rollingGO:0509019.6SELE, TNF, VCAM1
6positive regulation of cytokine secretionGO:0507159.6TNF, MIF
7interferon-gamma-mediated signaling pathwayGO:0603339.5ICAM1, HLA-DRB1, VCAM1
8cell agingGO:0075699.5MIF, ICAM1
9positive regulation of NF-kappaB transcription factor activityGO:0510929.3ICAM1, TNF, LTF
10angiogenesis involved in wound healingGO:0600559.1CX3CL1, SRF
11response to hypoxiaGO:0016669.0TNF, SRF, VCAM1
12cytokine-mediated signaling pathwayGO:0192218.8HLA-DRB1, ICAM1, VCAM1, CX3CL1

Products for genes affiliated with Rheumatoid Vasculitis

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Sources for Rheumatoid Vasculitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet