MCID: RHM014
MIFTS: 48

Rheumatoid Vasculitis malady

Rare diseases, Bone diseases, Cardiovascular diseases categories
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Summaries for Rheumatoid Vasculitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

MalaCards: Rheumatoid Vasculitis is related to vasculitis and arthritis. An important gene associated with Rheumatoid Vasculitis is SELE (selectin E), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Cellular roles of Anthrax toxin. The compounds 8 methoxypsoralen and sele have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related mouse phenotypes are growth/size/body and cellular.

Aliases & Classifications for Rheumatoid Vasculitis

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43NIH Rare Diseases, 45Novoseek, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Cardiovascular diseases


Aliases & Descriptions:

rheumatoid vasculitis 43 45 62


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ICD1025 M05.2

Related Diseases for Rheumatoid Vasculitis

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17GeneCards, 18GeneDecks
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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.4LTF, SELE, VCAM1, ICAM1, IL1RAPL2, TNF
2arthritis30.4TNF, SELE, SRF, MIF, IL1RAPL2, LTF
3rheumatoid arthritis30.3SELE, TNF, HLA-DRB1, LTF, IL1RAPL2, MIF
4glomerulonephritis30.1MIF, ICAM1, VCAM1
5myositis30.1IL1RAPL2, ICAM1, VCAM1
6hypertension30.0ICAM1, REN, VCAM1, SELE
7ankylosing spondylitis30.0SRF, TNF, IL1RAPL2
8endotheliitis10.3
9cerebritis10.2
10myocardial infarction10.2
11myopathy10.2
12nodular regenerative hyperplasia10.2
13foot drop10.2
14polyarteritis nodosa10.1LTF
15acute chest syndrome10.1VCAM1
16hepatorenal syndrome10.1REN
17peripheral vascular disease10.1SELE, VCAM1
18plummer's disease10.1ICAM1, SELE
19arteriosclerosis obliterans10.1ICAM1, VCAM1
20immunoglobulin a vasculitis10.1ICAM1, VCAM1
21inclusion body myositis10.1VCAM1, ICAM1
22allergic contact dermatitis10.1ICAM1, SELE
23oral lichen planus10.1ICAM1, VCAM1
24thyroiditis10.1HLA-DRB1
25leprosy10.1HLA-DRB1
26antiphospholipid syndrome10.1VCAM1, SELE
27vernal keratoconjunctivitis10.1ICAM1, VCAM1
28blau syndrome10.1TNF
29arteriosclerosis10.1ICAM1, VCAM1
30skin disease10.1HLA-DRB1
31gastrointestinal system disease10.1LTF, MIF
32leukostasis10.1SELE, VCAM1, ICAM1
33diabetic retinopathy10.1SRF, ICAM1, VCAM1
34polymyositis10.1SELE, ICAM1, VCAM1
35dermatitis10.1ICAM1, SELE, VCAM1
36allergic rhinitis10.1SELE, ICAM1, VCAM1
37rhinitis10.1ICAM1, VCAM1
38allergic asthma10.1SELE, ICAM1, VCAM1
39vascular disease10.0VCAM1, ICAM1, SELE
40acute myocardial infarction10.0SELE, MIF, SRF
41sickle cell disease10.0VCAM1, SELE
42lupus nephritis10.0VCAM1, ICAM1
43coronary artery disease10.0ICAM1, VCAM1, SELE
44urticaria10.0SELE, IL1RAPL2
45proliferative diabetic retinopathy10.0VCAM1, ICAM1, MIF
46polymyalgia rheumatica10.0IL1RAPL2, HLA-DRB1
47adult respiratory distress syndrome10.0TNF, SELE
48newborn respiratory distress syndrome10.0IL1RAPL2, MIF
49dermatomyositis10.0ICAM1, IL1RAPL2, VCAM1
50mononeuritis multiplex10.0

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to rheumatoid vasculitis

Symptoms for Rheumatoid Vasculitis

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Drugs & Therapeutics for Rheumatoid Vasculitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rheumatoid Vasculitis

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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33MalaCards
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MalaCards organs/tissues related to Rheumatoid Vasculitis:

33
Skin, Liver, Endothelial, Salivary gland, Bone, Retina

Animal Models for Rheumatoid Vasculitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0SRF, ICAM1, REN, VCAM1, SELE, TNF
2MP:00053847.2TNF, SELE, CX3CL1, ICAM1, SRF, MIF
3MP:00053857.1TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
4MP:00053976.6LTF, TNF, SELE, VCAM1, CX3CL1, REN
5MP:00053876.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1
6MP:00053766.5TNF, SELE, VCAM1, CX3CL1, REN, ICAM1

Publications for Rheumatoid Vasculitis

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52PubMed
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Articles related to Rheumatoid Vasculitis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. (23557520)
2013
2
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. (21385558)
2011
3
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. (19639318)
2010
4
Rheumatoid vasculitis: vanishing menace or target for new treatments? (20842467)
2010
5
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. (19714622)
2009
6
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. (19648728)
2009
7
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. (17318275)
2007
8
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. (17075825)
2006
9
Successful treatment of rheumatoid vasculitis-associated foot-drop with infliximab. (15801041)
2005
10
Decrease over time in the incidence of systemic rheumatoid vasculitis: Comment on the article by Turesson et al. (15880813)
2005
11
Testicular involvement in rheumatoid vasculitis. (15675137)
2004
12
Rheumatoid vasculitis: becoming extinct? (15126674)
2004
13
Pyothorax caused by Nocardia otitidiscaviarum in a patient with rheumatoid vasculitis. (15335193)
2004
14
Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. (15529352)
2004
15
Successful treatment of severe rheumatoid vasculitis by infliximab. (12759302)
2003
16
What is your diagnosis? Bywaters lesions of rheumatoid vasculitis. (12839252)
2003
17
Myocardial infarction caused by rheumatoid vasculitis: histological evidence of the involvement of T lymphocytes. (14634788)
2003
18
Rheumatoid vasculitis associated with anticardiolipin antibodies. (10599393)
1999
19
The diagnostic value of perivascular infiltrates in muscle biopsy specimens for the assessment of rheumatoid vasculitis. (9613342)
1998
20
Rheumatoid vasculitis presenting as appendicitis. (9844770)
1998
21
Breathlessness in a patient with rheumatoid vasculitis. (9713616)
1998
22
Reduced red blood cell deformability in patients with rheumatoid vasculitis. Improvement after in vitro treatment with dipyridamole. (7848316)
1995
23
Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endothelial leucocyte adhesion molecule are increased in patients with rheumatoid vasculitis. (7540479)
1995
24
Fatal pulmonary hypertension and rheumatoid vasculitis. (7758572)
1995
25
Rheumatoid vasculitis manifesting as intra-abdominal hemorrhage. (7776717)
1995
26
Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. (7966057)
1994
27
Gout masquerading as rheumatoid vasculitis. (8182655)
1994
28
Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. (8009014)
1993
29
Unusual DQA-DR haplotypes in rheumatoid vasculitis. (8428242)
1993
30
Muscular involvement in systemic rheumatoid vasculitis. (8348289)
1993
31
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy. (1556686)
1992
32
Muscular involvement in systemic rheumatoid vasculitis. (1581780)
1992
33
Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis. (2259841)
1990
34
Rheumatoid vasculitis with worsening nodulosis. (2313667)
1990
35
Anti-endothelial cell antibodies in patients with rheumatoid vasculitis. (2789049)
1989
36
Acute febrile neutrophilic dermatosis (Sweet's syndrome). Association with rheumatoid vasculitis. (2757408)
1989
37
Granulomatous cutaneous rheumatoid vasculitis. (3418621)
1988
38
Rheumatoid vasculitis with intrarenal aneurysm formation. (3172098)
1988
39
Platelet releasing activity in sera of patients with rheumatoid vasculitis. (3485407)
1986
40
Rheumatoid vasculitis: survival and associated risk factors. (3784899)
1986
41
Does joint inflammation improve as rheumatoid vasculitis develops? (4093933)
1985
42
Rheumatoid vasculitis: diagnostic and therapeutic decisions. (6678193)
1983
43
Rheumatoid vasculitis. (6678191)
1983
44
Plasma exchange in two patients with rheumatoid vasculitis. (7063814)
1982
45
Plasma exchange in rheumatoid vasculitis. (6976658)
1981
46
Rheumatoid vasculitis. (7309308)
1981
47
Myocardial infarction caused by rheumatoid vasculitis. (7406936)
1980
48
Ankylosing spondylitis with subsequent development of rheumatoid arthritis, SjAPgren's syndrome, and rheumatoid vasculitis. (646836)
1978
49
Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. (169295)
1975
50
Rheumatoid vasculitis. Report of a second case treated with penicillamine. (5302851)
1968

Variations for Rheumatoid Vasculitis

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Expression for genes affiliated with Rheumatoid Vasculitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for genes affiliated with Rheumatoid Vasculitis

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG
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Pathways related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7VCAM1, TNF
39.6ICAM1, TNF
4
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.5ICAM1, VCAM1, SELE
59.5SELE, VCAM1, ICAM1
69.5HLA-DRB1, TNF
7
Show member pathways
9.4HLA-DRB1, VCAM1, ICAM1
8
Show member pathways
9.3SRF, TNF
99.3TNF, VCAM1, ICAM1
109.3ICAM1, VCAM1, TNF
119.2MIF, ICAM1, TNF
12
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
13
Show member pathways
9.2ICAM1, TNF, HLA-DRB1
149.2HLA-DRB1, TNF, ICAM1
159.1HLA-DRB1, SELE, VCAM1, ICAM1
169.0ICAM1, VCAM1, SELE, TNF
179.0TNF, SELE, VCAM1, ICAM1
188.9TNF, VCAM1, ICAM1, MIF
19
Show member pathways
8.4VCAM1, CX3CL1, ICAM1, SRF
208.2HLA-DRB1, TNF, VCAM1, ICAM1, SRF
218.2ICAM1, CX3CL1, VCAM1, SELE, TNF
22
Show member pathways
8.1MIF, SRF, CX3CL1, TNF

Compounds for genes affiliated with Rheumatoid Vasculitis

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
18 methoxypsoralen459.8SELE, VCAM1, ICAM1
2sele459.8ICAM1, VCAM1, SELE
3metronidazole45 1110.8LTF, VCAM1, SELE
4ro 31-7549459.7VCAM1, SELE, TNF
5gliclazide45 51 1111.7ICAM1, VCAM1, SELE
6celastrol45 6110.7TNF, VCAM1, SELE
7gold sodium thiomalate459.4HLA-DRB1, SELE, TNF
8mycophenolic acid45 51 1111.4ICAM1, IL1RAPL2, VCAM1, SELE
9apocynin45 6110.4SELE, ICAM1, VCAM1, TNF
10groalpha459.4TNF, SELE, VCAM1, ICAM1
118-isoprostane459.4ICAM1, TNF, SELE, VCAM1
12budesonide45 51 1111.4VCAM1, LTF, ICAM1, TNF
13fenofibrate45 51 1111.3ICAM1, SELE, VCAM1, TNF
14pdtc459.3ICAM1, VCAM1, TNF, SELE
15sulfasalazine29 45 51 1112.2IL1RAPL2, TNF, SELE, ICAM1
16polymyxin b459.1LTF, ICAM1, VCAM1, SELE, TNF
17cytochalasin d45 6110.1SELE, LTF, VCAM1, IL1RAPL2, ICAM1
18cyclophosphamide45 51 1111.0LTF, IL1RAPL2, MIF, VCAM1, SELE
19herbimycin a45 6110.0MIF, TNF, SELE, VCAM1, ICAM1
20atorvastatin45 51 29 24 1113.0TNF, ICAM1, VCAM1, SELE
21troglitazone45 29 61 1112.0TNF, VCAM1, ICAM1, SELE
22homocysteine45 2410.0VCAM1, MIF, SRF, SELE
23n acetylcysteine459.0LTF, ICAM1, SELE, TNF, VCAM1
24sb 20358045 619.9SELE, TNF, ICAM1, MIF, VCAM1
25isoproterenol45 119.9LTF, SRF, SELE, VCAM1, REN
26pentoxifylline45 119.9VCAM1, ICAM1, IL1RAPL2, LTF, TNF
27simvastatin45 51 61 29 24 1113.9IL1RAPL2, ICAM1, VCAM1, SELE, TNF
28okt3458.8TNF, SELE, VCAM1, ICAM1, SRF
29fmlp458.8IL1RAPL2, LTF, ICAM1, VCAM1, TNF
30hydrocortisone45 3 61 1111.8REN, TNF, MIF, LTF
31prostacyclin458.7REN, ICAM1, TNF, LTF, VCAM1, SELE
32actinomycin d458.7SELE, ICAM1, IL1RAPL2, LTF, TNF
33neopterin458.6IL1RAPL2, SRF, ICAM1, LTF, TNF
34rosiglitazone29 45 51 24 1112.5IL1RAPL2, VCAM1, SELE, TNF
35rantes458.5SELE, IL1RAPL2, MIF, ICAM1, TNF, VCAM1
36genistein45 29 61 3 24 1113.4ICAM1, SELE, TNF, MIF, SRF, VCAM1
37methotrexate51 45 1110.4SRF, SELE, TNF, HLA-DRB1, IL1RAPL2
38creatinine458.3SELE, IL1RAPL2, REN, SRF, MIF, LTF
39alanine458.2HLA-DRB1, SELE, VCAM1, SRF, MIF, LTF
40norepinephrine45 24 1110.1MIF, LTF, IL1RAPL2, SRF, REN, VCAM1
41fibrinogen458.0SELE, IL1RAPL2, TNF, VCAM1, ICAM1, SRF
42histamine45 29 2410.0IL1RAPL2, TNF, SELE, VCAM1, ICAM1, SRF
43lactate457.9MIF, TNF, SELE, VCAM1, IL1RAPL2, ICAM1
44retinoic acid45 248.8ICAM1, TNF, VCAM1, MIF, SRF, IL1RAPL2
45endotoxin457.6VCAM1, ICAM1, SRF, MIF, IL1RAPL2, LTF
46nitric oxide45 24 119.5SELE, MIF, IL1RAPL2, TNF, SRF, ICAM1
47dexamethasone45 51 29 1110.5IL1RAPL2, REN, LTF, MIF, SRF, TNF
48pge2457.2VCAM1, TNF, SELE, REN, ICAM1, SRF
49vegf457.2VCAM1, SELE, ICAM1, LTF, SRF, MIF
50serine457.1SRF, IL1RAPL2, CX3CL1, LTF, MIF, VCAM1

GO Terms for genes affiliated with Rheumatoid Vasculitis

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16Gene Ontology
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Cellular components related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF, HLA-DRB1
2cell surfaceGO:0099868.4TNF, VCAM1, CX3CL1, MIF
3extracellular regionGO:0055768.0LTF, MIF, REN, CX3CL1, TNF
4extracellular spaceGO:0056157.2LTF, TNF, SELE, VCAM1, CX3CL1, REN
5plasma membraneGO:0058867.0HLA-DRB1, TNF, SELE, VCAM1, CX3CL1, REN

Biological processes related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.1ICAM1, VCAM1
2cell agingGO:00756910.0ICAM1, MIF
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.9MIF, TNF
4leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1, SELE
5heterophilic cell-cell adhesionGO:0071579.9SELE, VCAM1, ICAM1
6positive regulation of cytokine secretionGO:0507159.8TNF, MIF
7positive regulation of nitric oxide biosynthetic processGO:0454299.8ICAM1, TNF
8calcium-mediated signalingGO:0197229.8SELE, TNF
9response to lipopolysaccharideGO:0324969.8SELE, VCAM1, REN
10response to ionizing radiationGO:0102129.7VCAM1, ICAM1
11leukocyte tethering or rollingGO:0509019.7TNF, SELE, VCAM1
12interferon-gamma-mediated signaling pathwayGO:0603339.7HLA-DRB1, VCAM1, ICAM1
13positive regulation of MAP kinase activityGO:0434069.6MIF, TNF
14positive regulation of NF-kappaB transcription factor activityGO:0510929.5LTF, ICAM1, TNF
15cellular response to glucose stimulusGO:0713339.5SRF, ICAM1, VCAM1
16regulation of cell adhesionGO:0301559.5ICAM1, SRF
17inflammatory responseGO:0069549.4MIF, SELE, TNF
18angiogenesis involved in wound healingGO:0600559.3SRF, CX3CL1
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3TNF, CX3CL1
20response to hypoxiaGO:0016669.3SRF, VCAM1, TNF
21extracellular matrix organizationGO:0301989.0ICAM1, VCAM1, TNF
22cytokine-mediated signaling pathwayGO:0192218.4IL1RAPL2, ICAM1, CX3CL1, VCAM1, HLA-DRB1

Molecular functions related to Rheumatoid Vasculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.9MIF, REN, CX3CL1

Products for genes affiliated with Rheumatoid Vasculitis

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  • Antibodies
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Sources for Rheumatoid Vasculitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet