Aliases & Classifications for Rhinitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT
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Rhinitis, Aliases & Descriptions:

Name: Rhinitis 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:4483
NCIt38 C34986
SNOMED-CT55 70076002
MeSH33 D012220

Summaries for Rhinitis

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Disease Ontology:9 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards based summary: Rhinitis is related to asthma and vasomotor rhinitis. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs hyoscyamine sulfate and ephedrine and the compounds ltc4 and praziquantel have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:63 Rhinitis /ra??na?t?s/ or coryza is irritation and inflammation of the mucous membrane inside the nose.... more...

Related Diseases for Rhinitis

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Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.3CCL11, IL13
2vasomotor rhinitis32.1RNASE3, VIP
3chronic rhinitis32.0RNASE3, HRH1
4sinusitis31.2IL5, CCL11, RNASE3, IGHE
5conjunctivitis31.2HRH1, RNASE3, IGHE
6otitis media30.9CCL11, RNASE3, IGHE
7bronchitis30.9RNASE3
8allergic bronchopulmonary aspergillosis30.5IGHE, IL4, IL5
9urticaria30.4IGHE, FCER2, RNASE3, KNG1, HRH1
10dermatitis30.2IGHE, FCER2, RNASE3, IL4, IL4R, IL13
11mastocytosis30.2IGHE, IL5, IL13
12common cold30.2RNASE3, ICAM1, CCL11, IL8
13keratoconjunctivitis30.2IL13, IL5, CCL11, RNASE3
14allergic conjunctivitis30.1IL13, IL5, IL4, CCL11, RNASE3, IGHE
15churg-strauss syndrome30.0IL5, RNASE3, MPO
16intrinsic asthma29.8IGHE, FCER2, RNASE3, IL4, IL5
17food allergy29.8IL13, IL5, IL4, CCL11, EPX, RNASE3
18atopy29.7IL13, IL4R, IL5, IL4, CCL11, EPX
19cystic fibrosis29.7MPO, RNASE3, VIP, IL8
20chronic lymphocytic leukemia29.6IL4, ICAM1, FCER2
21bronchiectasis29.5IGHE, MPO, RNASE3, IL8
22graves' disease29.5MPO, ICAM1, IL4, IL4R, IL13
23pneumonia29.3IL13, IL8, IL5, CCL11, ICAM1, EPX
24allergic rhinitis29.2HRH1, KNG1, IL13, IL8, IL4R, IL5
25eosinophilia29.0IL13, IL8, IL5, IL4, CCL11, EPX
26allergic asthma28.7HRH1, IL13, IL8, IGHE, NGF, IL4R
27leukemia28.7NGF, MPO, FCER2, RNASE3, EPX, ICAM1
28vernal keratoconjunctivitis28.6IL13, IL8, IL5, IL4, CCL11, ICAM1
29atopic dermatitis28.1HRH1, IL13, NGF, IGHE, FCER2, RNASE3
30atrophic rhinitis11.2
31blindness10.6
32folliculitis10.6CCL11
33collagenous colitis10.5RNASE3
34eosinophil peroxidase deficiency10.5EPX
35impotence10.5VIP
36cystitis10.5NGF
37esophagitis, eosinophilic, 110.4IL5, CCL11
38corneal ulcer10.4NGF, CCL11
39schistosomiasis10.4IL13, IL5
40mononeuropathy10.4MPO
41anisakiasis10.4IGHE, RNASE3
42paragonimiasis10.4IL5, IGHE
43toxocariasis10.4IGHE, RNASE3
44pulpitis10.4KNG1
45strongyloidiasis10.4IGHE, IL5
46nephrotic syndrome10.4CCL11, IL4R, IL13
47esophagitis10.3CCL11, IL5, IL13
48proctitis10.3RNASE3, EPX
49contact dermatitis10.3IGHE, IL5
50chronic eosinophilic pneumonia10.3RNASE3, CCL11, IL5

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Symptoms for Rhinitis

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Drugs & Therapeutics for Rhinitis

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Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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MalaCards organs/tissues related to Rhinitis:

31
Testes, Eye, T cells, Skin, Bone, Lung, Neutrophil, B cells, Endothelial, Heart, Colon, Liver, Thyroid, Tonsil, Bone marrow, Lymph node, Spleen, Thymus, Salivary gland, Monocytes, Nk cells

Animal Models for Rhinitis or affiliated genes

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MGI Mouse Phenotypes related to Rhinitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5VIP, FOXJ1, CCL11, IL4, IL5, IL4R
2MP:00053818.2FCER2, ICAM1, FOXJ1, IL4, IL5, IL4R
3MP:00053787.6ICAM1, FOXJ1, IL4, IL5, IL4R, IL13
4MP:00107687.1NGF, MPO, FCER2, VIP, ADH5, ICAM1
5MP:00053976.2ICAM1, EPX, FCER2, MPO, IGHE, CCL11
6MP:00053766.0VIP, FCER2, MPO, NGF, IGHE, ADH5
7MP:00053875.7HRH1, IGHE, MPO, FCER2, EPX, VIP

Publications for Rhinitis

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Articles related to Rhinitis:

(show top 50)    (show all 2079)
idTitleAuthorsYear
1
The impact of co-existing seasonal allergic rhinitis caused by Japanese Cedar Pollinosis (SAR-JCP) upon asthma control status. (25838090)
2015
2
Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study. (25363381)
2014
3
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
4
Seroprevalence study of Equine rhinitis B virus (ERBV) in Australian weanling horses using serotype-specific ERBV enzyme-linked immunosorbent assays. (23960171)
2013
5
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
6
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
7
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
8
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
9
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. (24274229)
2013
10
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
11
Nasal mucosa temperature as a marker of disease in children with allergic rhinitis. (22801008)
2012
12
Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. (22411430)
2012
13
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
14
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
15
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
16
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
17
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
18
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
19
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
20
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
21
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
22
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
23
How safe are the biologicals in treating asthma and rhinitis? (20016776)
2009
24
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
25
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
26
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
27
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
28
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
29
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
30
Transforming growth factor-alpha and rhinitis. (10401853)
1999
31
Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. (10543283)
1999
32
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
33
Endoscopic sinus surgery and postoperative intravenous aminoglycosides in the treatment of atrophic rhinitis. (9805532)
1998
34
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
35
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
36
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
37
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
38
Reopening of the closed nostril in atrophic rhinitis. (3397634)
1988
39
Nasal histamine and heparin in chronic rhinitis. (3408114)
1988
40
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
41
Atrophic rhinitis in swine: correlation of Pasteurella multocida pathogenicity with membrane protein and lipopolysaccharide patterns. (6480114)
1984
42
Cryosurgery on postganglionic fibers (posterior nasal branches) of the pterygopalatine ganglion for vasomotor rhinitis. (6613543)
1983
43
The ozena problem. Clinical analysis of atrophic rhinitis in 100 cases. (7102303)
1982
44
Experimental atrophic rhinitis in gnotobiotic pigs. (7448626)
1980
45
Double-blind comparison of metizoline hydrochloride (Ellsyl) and phenylephrine in allergic and vasomotor rhinitis. (49255)
1975
46
Vidian neurectomy in vasomotor rhinitis. (4771966)
1973
47
Clinical and immunologic studies on fetid atrophic rhinitis (ozena) of the nasopharyngeal cavity treated with a specific vaccine. (4771981)
1973
48
Histopathological and histochemical studies on atrophic rhinitis. (5476397)
1970
49
Vasomotor rhinitis. (14388570)
1955
50
The management of vasomotor rhinitis. (18894292)
1948

Variations for Rhinitis

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Expression for genes affiliated with Rhinitis

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Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

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Pathways related to Rhinitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL4, IL4R
29.7IL13, IL5, IL4
39.7IL4, IL5, IL13
49.7IL4, IL5, IL4R
59.7IL13, IL8, NGF
69.6ICAM1, MPO
7
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.6IL8, IL4, CCL11
89.5IL4, IL5, IL4R, IL13
9
Show member pathways
9.5IL4, IL5, IL4R, IL13
10
Show member pathways
Type III interferon signaling36
9.5IL13, IL4R, IL5, IL4
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.5IL8, IL5, IL4
12
Show member pathways
9.5IL8, CCL11, ICAM1
139.4IL8, IL4, ICAM1
149.4FCER2, IL4, IL5, IL4R
159.3KNG1, ICAM1, MPO
169.3IL4, IL5, IL8, IL13
17
Show member pathways
9.2ICAM1, IL4, IL8, IL13
18
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.2IGHE, IL4, IL5, IL13
198.9IL13, IL8, IL5, IL4, ICAM1
20
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
8.9IGHE, FCER2, CCL11, IL4, IL4R
21
Show member pathways
8.9CCL11, IL4, IL5, IL4R, IL8, IL13
22
Show member pathways
8.9CCL11, IL4, IL5, IL4R, IL8, IL13
23
Show member pathways
8.9IL13, IL8, IL4R, IL5, IL4, CCL11
24
Show member pathways
8.9CCL11, IL13, IL8, IL4R, IL5, IL4
258.6IGHE, FCER2, CCL11, IL4, IL5, IL4R
26
Show member pathways
8.5FCER2, CCL11, IL4, IL5, IL4R, IL8
27
Show member pathways
8.4IL13, RNASE3, EPX, ICAM1, CCL11, IL4
28
Show member pathways
7.9NGF, FCER2, VIP, CCL11, IL8, KNG1

Compounds for genes affiliated with Rhinitis

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Compounds related to Rhinitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 242)
idCompoundScoreTop Affiliating Genes
1ltc4439.4RNASE3, EPX, VIP, IL13, IL5, CCL11
2praziquantel43 1210.2IL13, IL4, IL5, RNASE3, IGHE
3unicap439.1IGHE, IL5, CCL11, RNASE3
4pgd2439.1RNASE3, IL5, CCL11, IGHE, EPX, IL13
5salmeterol43 49 28 1212.0IL13, IL8, IL5, IL4, CCL11, EPX
6levocetirizine438.9CCL11, IL4, IL8, HRH1
7omalizumab43 129.9IGHE, IL13, IL5, IL4
8rolipram43 59 2810.9IL4, IL5, CCL11, EPX, IL8, KNG1
9n-formylmethionyl-leucylphenylalanine438.8MPO, ICAM1, IL5, RNASE3, CCL11, IL8
10montelukast43 49 28 1211.8IL13, IL8, IL5, IL4, CCL11, RNASE3
11ionomycin438.7KNG1, IL13, IL5, IL4, CCL11, IL4R
12ltd4438.7IL5, IL13, KNG1, HRH1, RNASE3, VIP
13anti-histamine438.6RNASE3, IGHE, HRH1, CCL11, ICAM1
14herbimycin a43 599.5NGF, FCER2, CCL11, IL4, ICAM1, IL5
15sb 20358043 599.5IL13, CCL11, IL4, NGF, FCER2, ICAM1
16loratadine43 24 1210.4RNASE3, ICAM1, IL8, HRH1, IGHE
17tarc438.4IL4, CCL11, ICAM1, IGHE, IL5, IL4R
18fluticasone propionate43 49 59 1211.3MPO, IGHE, RNASE3, IL5, IL4, IL13
19azelastine43 129.3IL5, HRH1, IL4, ICAM1, RNASE3, IGHE
20erythromycin43 2 49 1211.3MPO, IL8, IL13, HRH1, IL5, VIP
21desloratadine43 129.3HRH1, IL13, IL8, IL4, ICAM1, IGHE
22prednisolone43 28 1210.3NGF, MPO, RNASE3, EPX, VIP, CCL11
23salbutamol43 49 28 24 1212.2IL13, IL8, IL5, CCL11, VIP, EPX
24ketotifen43 129.2HRH1, IL5, CCL11, IGHE, RNASE3, EPX
25capsaicin43 289.2NGF, IL5, RNASE3, IGHE, HRH1, KNG1
26leukotriene b443 59 2410.2EPX, CCL11, IL5, IL8, IL13, KNG1
27sodium cromoglycate438.2HRH1, IL5, CCL11, ICAM1, EPX, RNASE3
28fmlp438.1IL13, IL8, IL5, MPO, FCER2, RNASE3
29actinomycin d438.0IL4, IL4R, IL8, CCL11, ICAM1, NGF
30thymidine43 248.9IL4R, NGF, HRH1, IL13, IL5, IL4
31isoproterenol43 128.9HRH1, KNG1, IL13, IL4, VIP, IGHE
32heparin43 28 24 1210.8IL13, IL8, IL5, CCL11, EPX, KNG1
33lactate437.7IL8, IL13, RNASE3, FCER2, ICAM1, VIP
34cycloheximide437.7FCER2, KNG1, IL13, IL5, IL8, IL4R
35budesonide43 49 129.6IL13, IL8, IL5, IL4, CCL11, ICAM1
36rantes437.6HRH1, IL13, RNASE3, VIP, ICAM1, CCL11
37nedocromil sodium437.6HRH1, IL8, IL5, IL4, ICAM1, RNASE3
38allergens437.5IL4R, IL5, IL4, CCL11, EPX, RNASE3
39adenylate437.5KNG1, IL5, IL4, HRH1, NGF, RNASE3
40cetirizine43 28 24 1210.5CCL11, ICAM1, EPX, RNASE3, IGHE, IL5
41retinoic acid43 248.4IGHE, NGF, MPO, RNASE3, ADH5, CCL11
42vegf437.4NGF, MPO, RNASE3, VIP, ICAM1, IL8
43methacholine43 49 129.4IGHE, MPO, RNASE3, VIP, ICAM1, CCL11
44indomethacin43 28 59 1210.3IL4, IL5, IL13, KNG1, HRH1, CCL11
45tyrosine437.3CCL11, IL5, IL4R, IL13, KNG1, IL4
46cyclosporin a43 28 598.9IGHE, NGF, RNASE3, VIP, ICAM1, CCL11
47nitric oxide43 24 128.7RNASE3, KNG1, HRH1, IL13, IL8, CCL11
48pge2436.4VIP, EPX, ICAM1, CCL11, IL4, IL5
49dexamethasone43 49 28 129.2IGHE, NGF, FCER2, RNASE3, VIP, ICAM1
50histamine43 28 247.5VIP, ICAM1, CCL11, IL4, IL5, IL4R

GO Terms for genes affiliated with Rhinitis

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Cellular components related to Rhinitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3IL13, IL4, ICAM1, FCER2
2extracellular spaceGO:00056157.7IL13, NGF, MPO, ICAM1, CCL11, IL4
3extracellular regionGO:00055767.5IGHE, NGF, RNASE3, VIP, CCL11, IL5

Biological processes related to Rhinitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:004303210.2IL4R, IL13
2regulation of proton transportGO:001015510.2IL13, IL4
3defense response to protozoanGO:004283210.0IL4R, IL4
4positive regulation of B cell proliferationGO:003089010.0IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.8IL5, IL4, NGF
6response to ethanolGO:00454719.8IL13, IL4, ICAM1
7eosinophil chemotaxisGO:00482459.7CCL11, HRH1
8hydrogen peroxide catabolic processGO:00427449.6EPX, MPO
9response to lipopolysaccharideGO:00324969.6NGF, MPO, ADH5, IL13
10chemotaxisGO:00069359.6CCL11, IL4, IL8
11negative regulation of apoptotic processGO:00430669.2IL4, VIP, MPO, NGF
12positive regulation of vasoconstrictionGO:00459079.0ICAM1, HRH1
13immune responseGO:00069558.6IGHE, CCL11, IL4, IL5, IL4R, IL8
14inflammatory responseGO:00069548.3HRH1, NGF, CCL11, IL5, IL8, IL13

Molecular functions related to Rhinitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.7IL13, IL5, IL4
2peroxidase activityGO:00046019.6EPX, MPO
3growth factor activityGO:00080839.4IL5, IL4, NGF

Products for genes affiliated with Rhinitis

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Sources for Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet