MCID: RHN004
MIFTS: 65

Rhinitis malady

Respiratory diseases category

Summaries for Rhinitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards: Rhinitis, also known as rhinitis, nos, is related to asthma and vasomotor rhinitis. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs hyoscyamine sulfate and ephedrine and the compounds ltc4 and praziquantel have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:66 Rhinitis /ra??na?t?s/ or coryza is irritation and inflammation of the mucous membrane inside the nose.... more...

Aliases & Classifications for Rhinitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

rhinitis 9 11 46 63
rhinitis, nos 9


External Ids:

Disease Ontology9 DOID:4483
NCIt41 C34986
SNOMED-CT59 70076002
MeSH36 D012220

Related Diseases for Rhinitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.7CCL11, IL13
2vasomotor rhinitis31.7RNASE3, VIP
3chronic rhinitis31.5RNASE3, HRH1
4allergic rhinitis31.4CCL11, RNASE3, EPX, VIP, ICAM1, HRH1
5sinusitis30.9CCL11, RNASE3, IGHE, IL5
6conjunctivitis30.8HRH1, RNASE3, IGHE
7atopy30.6IL13, IL4R, IL5, IGHE, MPO, FCER2
8urticaria30.5FCER2, KNG1, HRH1, RNASE3, IGHE
9otitis media30.5IGHE, RNASE3, CCL11
10pneumonia30.4HRH1, KNG1, IL13, IL5, CCL11, ICAM1
11common cold30.4IL8, ICAM1, RNASE3, CCL11
12dermatitis30.4IL13, IL5, IL4, CCL11, ICAM1, IGHE
13allergic conjunctivitis30.3IGHE, RNASE3, CCL11, IL4, IL5, IL13
14allergic asthma30.3FCER2, NGF, IGHE, RNASE3, EPX, ICAM1
15eosinophilia30.3IGHE, NGF, MPO, IL13, IL8, IL5
16allergic bronchopulmonary aspergillosis30.2IGHE, IL5, IL4
17mastocytosis30.1IL13, IGHE, IL5
18intrinsic asthma30.0RNASE3, IL5, IL4, FCER2, IGHE
19cystic fibrosis29.9IL8, VIP, RNASE3, MPO
20food allergy29.9IL5, IL4, CCL11, EPX, RNASE3, IGHE
21anisakiasis29.9IGHE, RNASE3
22giant papillary conjunctivitis29.9RNASE3, CCL11, IL5
23atopic dermatitis29.9IGHE, NGF, FCER2, RNASE3, EPX, VIP
24keratoconjunctivitis29.9IL5, IL13, CCL11, RNASE3
25churg-strauss syndrome29.8IL5, RNASE3, MPO
26bronchiectasis29.7IGHE, IL8, RNASE3, MPO
27graves' disease29.7IL4R, IL4, MPO, IL13, ICAM1
28leukemia29.7RNASE3, EPX, NGF, MPO, CCL11, IL4
29vernal keratoconjunctivitis29.5IL13, IL8, IL5, IL4, CCL11, ICAM1
30atrophic rhinitis11.1
31blindness10.6
32nasopharyngitis10.3
33neuronitis10.2
34aspergillosis10.2
35ectodermal dysplasia10.2
36endotheliitis10.2
37adenoiditis10.2
38laryngitis10.2
39klebsiella10.2
40folliculitis10.1CCL11
41bronchitis10.1RNASE3
42collagenous colitis10.1RNASE3
43eosinophil peroxidase deficiency10.1EPX
44cystitis10.1NGF
45impotence10.1VIP
46eosinophilic esophagitis10.1CCL11, IL5
47corneal ulcer10.1CCL11, NGF
48mononeuropathy10.1MPO
49pharyngitis10.1
50pleuropneumonia10.1

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Symptoms for Rhinitis

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Drugs & Therapeutics for Rhinitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Rhinitis:

34
Testes, Eye, T cells, Skin, Lung, Bone, B cells, Endothelial, Liver, Tonsil, Heart, Thyroid, Colon, Thymus, Monocytes, Nk cells, Spleen, Lymph node, Bone marrow

Animal Models for Rhinitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Rhinitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5VIP, CCL11, IL4, IL5, IL4R, IL13
2MP:00053818.2IL13, IL4R, IL5, IL4, ICAM1, FCER2
3MP:00053787.6HRH1, IL13, IL4R, IL5, FOXJ1, ICAM1
4MP:00107687.1FCER2, VIP, ADH5, ICAM1, FOXJ1, IL4
5MP:00053976.2IGHE, HRH1, EPX, ICAM1, CCL11, MPO
6MP:00053766.0IGHE, NGF, MPO, FCER2, HRH1, KNG1
7MP:00053875.7FCER2, IGHE, EPX, VIP, ADH5, HRH1

Publications for Rhinitis

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Sources:
53PubMed
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Articles related to Rhinitis:

(show top 50)    (show all 2013)
idTitleAuthorsYear
1
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
2
Seroprevalence study of Equine rhinitis B virus (ERBV) in Australian weanling horses using serotype-specific ERBV enzyme-linked immunosorbent assays. (23960171)
2013
3
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
4
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
5
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
6
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
7
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. (24274229)
2013
8
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
9
Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. (22411430)
2012
10
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
11
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
12
The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. (22656186)
2012
13
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
14
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
15
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
16
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
17
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
18
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
19
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
20
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
21
How safe are the biologicals in treating asthma and rhinitis? (20016776)
2009
22
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
23
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
24
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
25
Suppressive effect of fluticasone propionate on MMP expression in the nasal mucosa of allergic rhinitis patients in vivo. (16900772)
2006
26
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
27
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
28
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
29
Transforming growth factor-alpha and rhinitis. (10401853)
1999
30
Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. (10543283)
1999
31
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
32
Endoscopic sinus surgery and postoperative intravenous aminoglycosides in the treatment of atrophic rhinitis. (9805532)
1998
33
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
34
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
35
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
36
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
37
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993
38
Reopening of the closed nostril in atrophic rhinitis. (3397634)
1988
39
Nasal histamine and heparin in chronic rhinitis. (3408114)
1988
40
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
41
Atrophic rhinitis in swine: correlation of Pasteurella multocida pathogenicity with membrane protein and lipopolysaccharide patterns. (6480114)
1984
42
Cryosurgery on postganglionic fibers (posterior nasal branches) of the pterygopalatine ganglion for vasomotor rhinitis. (6613543)
1983
43
The ozena problem. Clinical analysis of atrophic rhinitis in 100 cases. (7102303)
1982
44
Experimental atrophic rhinitis in gnotobiotic pigs. (7448626)
1980
45
Double-blind comparison of metizoline hydrochloride (Ellsyl) and phenylephrine in allergic and vasomotor rhinitis. (49255)
1975
46
Vidian neurectomy in vasomotor rhinitis. (4771966)
1973
47
Clinical and immunologic studies on fetid atrophic rhinitis (ozena) of the nasopharyngeal cavity treated with a specific vaccine. (4771981)
1973
48
Histopathological and histochemical studies on atrophic rhinitis. (5476397)
1970
49
Vasomotor rhinitis. (14388570)
1955
50
The management of vasomotor rhinitis. (18894292)
1948

Variations for Rhinitis

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Expression for genes affiliated with Rhinitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhinitis

Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 31KEGG, 13EMD Millipore, 56Reactome
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Pathways related to Rhinitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL4R, IL4
29.7IL4, IL5, IL13
39.7IL13, IL5, IL4
49.7IL4R, IL5, IL4
59.7IL8, NGF, IL13
69.6ICAM1, MPO
7
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.6IL8, CCL11, IL4
8
Show member pathways
Type III interferon signaling39
9.5IL4, IL4R, IL5, IL13
99.5IL4R, IL4, IL5, IL13
10
Show member pathways
9.5IL4R, IL4, IL13, IL5
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.5IL8, IL4, IL5
12
Show member pathways
9.5CCL11, IL8, ICAM1
139.4ICAM1, IL4, IL8
149.4IL4R, IL5, IL4, FCER2
159.3MPO, KNG1, ICAM1
169.3IL13, IL5, IL4, IL8
179.3CCL11, IL8, IL5, IL4
18
Show member pathways
9.2IL13, IL4, IL8, ICAM1
19
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.2IL5, IL4, IGHE, IL13
208.9IL4, IL5, IL8, IL13, ICAM1
21
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
8.9IL4R, IL4, CCL11, FCER2, IGHE
22
Show member pathways
8.9IL4R, IL5, IL4, CCL11, IL8, IL13
23
Show member pathways
8.9IL4R, IL5, IL4, CCL11, IL8, IL13
24
Show member pathways
8.9IL8, IL4R, IL5, IL4, IL13, CCL11
25
Show member pathways
8.9IL4R, IL8, IL13, IL5, IL4, CCL11
268.6IL4R, IGHE, FCER2, CCL11, IL4, IL5
27
Show member pathways
8.5IL4R, FCER2, CCL11, IL13, IL8, IL4
28
Show member pathways
8.4IL4R, RNASE3, EPX, ICAM1, CCL11, IL4
29
Show member pathways
7.9NGF, FCER2, VIP, CCL11, IL8, HRH1

Compounds for genes affiliated with Rhinitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 242)
idCompoundScoreTop Affiliating Genes
1ltc4469.4RNASE3, EPX, VIP, IL13, IL5, CCL11
2praziquantel46 1210.2IL13, IL4, IL5, RNASE3, IGHE
3unicap469.1IGHE, IL5, CCL11, RNASE3
4pgd2469.1RNASE3, IL5, CCL11, IGHE, EPX, IL13
5salmeterol46 52 30 1212.0IL13, IL8, IL5, IL4, CCL11, EPX
6levocetirizine468.9CCL11, IL4, IL8, HRH1
7omalizumab46 129.9IGHE, IL13, IL5, IL4
8rolipram46 62 3010.9IL4, IL5, CCL11, EPX, IL8, KNG1
9n-formylmethionyl-leucylphenylalanine468.8MPO, ICAM1, IL5, RNASE3, CCL11, IL8
10montelukast46 52 30 1211.8IL13, IL8, IL5, IL4, CCL11, RNASE3
11ionomycin468.7KNG1, IL13, IL5, IL4, CCL11, IL4R
12ltd4468.7IL5, IL13, KNG1, HRH1, RNASE3, VIP
13anti-histamine468.6RNASE3, IGHE, HRH1, CCL11, ICAM1
14herbimycin a46 629.5NGF, FCER2, CCL11, IL4, ICAM1, IL5
15sb 20358046 629.5IL13, CCL11, IL4, NGF, FCER2, ICAM1
16loratadine46 25 1210.4RNASE3, ICAM1, IL8, HRH1, IGHE
17tarc468.4IL4, CCL11, ICAM1, IGHE, IL5, IL4R
18fluticasone propionate46 52 62 1211.3MPO, IGHE, RNASE3, IL5, IL4, IL13
19azelastine46 129.3IL5, HRH1, IL4, ICAM1, RNASE3, IGHE
20erythromycin46 3 52 1211.3MPO, IL8, IL13, HRH1, IL5, VIP
21desloratadine46 129.3HRH1, IL13, IL8, IL4, ICAM1, IGHE
22prednisolone46 30 1210.3NGF, MPO, RNASE3, EPX, VIP, CCL11
23salbutamol46 52 30 25 1212.2IL13, IL8, IL5, CCL11, VIP, EPX
24ketotifen46 129.2HRH1, IL5, CCL11, IGHE, RNASE3, EPX
25capsaicin46 309.2NGF, IL5, RNASE3, IGHE, HRH1, KNG1
26leukotriene b446 62 2510.2EPX, CCL11, IL5, IL8, IL13, KNG1
27sodium cromoglycate468.2HRH1, IL5, CCL11, ICAM1, EPX, RNASE3
28fmlp468.1IL13, IL8, IL5, MPO, FCER2, RNASE3
29actinomycin d468.0IL4, IL4R, IL8, CCL11, ICAM1, NGF
30thymidine46 258.9IL4R, NGF, HRH1, IL13, IL5, IL4
31isoproterenol46 128.9HRH1, KNG1, IL13, IL4, VIP, IGHE
32heparin46 30 25 1210.8IL13, IL8, IL5, CCL11, EPX, KNG1
33lactate467.7IL8, IL13, RNASE3, FCER2, ICAM1, VIP
34cycloheximide467.7FCER2, KNG1, IL13, IL5, IL8, IL4R
35budesonide46 52 129.6IL13, IL8, IL5, IL4, CCL11, ICAM1
36rantes467.6HRH1, IL13, RNASE3, VIP, ICAM1, CCL11
37nedocromil sodium467.6HRH1, IL8, IL5, IL4, ICAM1, RNASE3
38allergens467.5IL4R, IL5, IL4, CCL11, EPX, RNASE3
39adenylate467.5KNG1, IL5, IL4, HRH1, NGF, RNASE3
40cetirizine46 30 25 1210.5CCL11, ICAM1, EPX, RNASE3, IGHE, IL5
41retinoic acid46 258.4IGHE, NGF, MPO, RNASE3, ADH5, CCL11
42vegf467.4NGF, MPO, RNASE3, VIP, ICAM1, IL8
43methacholine46 52 129.4IGHE, MPO, RNASE3, VIP, ICAM1, CCL11
44indomethacin46 30 62 1210.3IL4, IL5, IL13, KNG1, HRH1, CCL11
45tyrosine467.3CCL11, IL5, IL4R, IL13, KNG1, IL4
46cyclosporin a46 30 628.9IGHE, NGF, RNASE3, VIP, ICAM1, CCL11
47nitric oxide46 25 128.7RNASE3, KNG1, HRH1, IL13, IL8, CCL11
48pge2466.4VIP, EPX, ICAM1, CCL11, IL4, IL5
49dexamethasone46 52 30 129.2IGHE, NGF, FCER2, RNASE3, VIP, ICAM1
50histamine46 30 257.5VIP, ICAM1, CCL11, IL4, IL5, IL4R

GO Terms for genes affiliated with Rhinitis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL13, IL4, ICAM1, FCER2
2extracellular spaceGO:0056157.7IL13, NGF, MPO, ICAM1, CCL11, IL4
3extracellular regionGO:0055767.5IGHE, NGF, RNASE3, VIP, CCL11, IL5

Biological processes related to Rhinitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:04303210.2IL4R, IL13
2regulation of proton transportGO:01015510.2IL13, IL4
3defense response to protozoanGO:04283210.0IL4R, IL4
4positive regulation of B cell proliferationGO:03089010.0IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL5, IL4, NGF
6response to ethanolGO:0454719.8IL13, IL4, ICAM1
7eosinophil chemotaxisGO:0482459.7CCL11, HRH1
8hydrogen peroxide catabolic processGO:0427449.6EPX, MPO
9response to lipopolysaccharideGO:0324969.6NGF, MPO, ADH5, IL13
10chemotaxisGO:0069359.6CCL11, IL4, IL8
11negative regulation of apoptotic processGO:0430669.2IL4, VIP, MPO, NGF
12positive regulation of vasoconstrictionGO:0459079.0ICAM1, HRH1
13immune responseGO:0069558.6IGHE, CCL11, IL4, IL5, IL4R, IL8
14inflammatory responseGO:0069548.3HRH1, NGF, CCL11, IL5, IL8, IL13

Molecular functions related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.7IL13, IL5, IL4
2peroxidase activityGO:0046019.6EPX, MPO
3growth factor activityGO:0080839.4IL5, IL4, NGF

Products for genes affiliated with Rhinitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rhinitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet