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Rhinitis malady
13 drugs, 289 genes, 12 tissues, 913 related diseases, 23 phenotypes, 630 articles, clinical trials.

Summaries for Rhinitis

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Disease Ontology: A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.6

MalaCards: Rhinitis, also known as rhinitis (disorder), is related to allergic rhinitis and asthma. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are Immune System and Asthma. The drugs oxymetazoline and ephedrine and the compounds methacholine and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and thymus, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: Rhinitis (pron.: /raɪˈnaɪtɪs/) is a medical term for irritation and inflammation of the mucous...44 more...

Aliases & Descriptions for Rhinitis

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 27NCIt, 24MeSH, 40SNOMED-CT
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Aliases & Descriptions:

rhinitis 6 8 32 43
rhinitis (disorder) 6
rhinitis, nos 6

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SNOMED-CT40 70076002

Related Diseases for Rhinitis

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13GeneCards, 14GeneDecks
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Diseases related to rhinitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 910)
idRelated DiseaseScoreTop Affiliating Genes
1allergic rhinitis42.7SELE, VIP, VCAM1, IL13, IL4, IL5
2asthma38.3SCGB1A1, SCGB3A2, IL12B, IL13, CCL11, HNMT
3allergic asthma37.4SERPINE1, VCAM1, BDNF, BCL2, SCGB1A1, MS4A2
4bronchial asthma36.7KITLG, SFTPD, SELE, SELL, VIP, VEGFA
5atopy35.4RELA, KITLG, VEGFA, CMA1, KDR, SCGB1A1
6atopic dermatitis35.0PDE4A, KITLG, SELE, SELL, VIP, VCAM1
7eosinophilia34.7PDE4A, SFTPA1, SFTPA2, SFTPD, SELL, VCAM1
8chronic rhinitis34.6MPO, CALCA, HRH1, RNASE3, EDN1, ECE1
9vasomotor rhinitis34.6VIP, IL10, IL13, IL16, IFT122, CALCA
10urticaria33.5KITLG, SELE, SERPINB1, VEGFA, VCAM1, CMA1
11dermatitis33.1PDE4A, RELA, KITLG, SFTPD, BTK, SELE
12blindness31.9PIK3CG, PDE4A, SELE, SERPINF1, SERPINE1, VIP
13eczema31.6BTK, SELE, VIP, CMA1, MS4A2, MPO
14otitis media31.0SFTPA1, SFTPA2, SELL, SERPINE1, VCAM1, MUC1
15chronic fatigue syndrome30.4VIP, CD4, IL10, IL1R1, IL4, IL6
16sinusitis30.4RELA, SFTPD, BTK, SELL, SERPINE1, VEGFA
17vernal keratoconjunctivitis30.3VCAM1, CMA1, MMP9, IL13, IL3, IL4
18keratoconjunctivitis29.9RELA, VIPR1, VEGFA, VCAM1, CMA1, MUC5AC
19polyposis29.8PIK3CG, RELA, KITLG, SELE, SERPINE1, VIP
20intrinsic asthma29.8FCER2, IL3, IL4, IL5, CCL7, CCL5
21allergic conjunctivitis29.6IL13, IL4, IL5, CCL11, IGHE, HRH1
22common cold29.5CHIA, IL1R1, IL5, IL8, CCL11, ICAM1
23allergic bronchopulmonary aspergillosis29.3SFTPD, IL4, IL5, MBL2, IGES, IGHE
24fibromyalgia28.9SELL, SERPINE1, BGLAP, BDNF, CHKB, IL10
25conjunctivitis28.8KITLG, BTK, VEGFA, BCL2, LACTB, MS4A2
26pulmonary function28.8LEP, CHIA, MPO, CD14, IL10, IL13
27aspergillosis28.4SFTPA1, SFTPA2, SFTPD, CD79A, CD4, IL10
28graves' disease28.1RETN, KITLG, SELE, SELL, VCAM1, BGLAP
29leukemia27.8PIK3CD, PIK3CG, PDE4A, RELA, RETN, KITLG
30adenoiditis27.8RELA, VEGFA, VCAM1, KDR, BCL2, MUC1
31was-related disorders27.7BDNF, LEP, CHKB, MPO, IL2RA, IL6
32cystic fibrosis27.2PIK3CG, PDE4A, SFTPA1, SFTPD, SELL, SERPINB1
33fibrosis26.3PIK3CG, PDE4A, RELA, RETN, KITLG, SFTPA1
34carcinoma25.6PIP, PIK3CD, PIK3CG, PDE4A, RELA, RETN
35neuronitis25.5PIK3CD, PIK3CG, PDE4A, RELA, RETN, KITLG
36squamous cell carcinoma25.2PIP, RELA, SELL, SERPINF1, VEGFA, CMA1
37nasopharyngitis24.6PIK3CG, RELA, KITLG, SEPT3, VEGFA, VCAM1
38hypoxia24.0PIK3CD, PIK3CG, PDE4A, RELA, KITLG, SFTPA1
39wheat allergic reaction16.5KITLG, SFTPD, SELE, SELL, VCAM1, BDNF
40gonococcal synovitis15.7PIK3CG, PDE4A, RELA, RETN, KITLG, SFTPD
41bronchiolitis15.7KITLG, SFTPA1, SFTPD, SELE, SELL, VIP
42pulmonary eosinophilia15.5PDE4A, SFTPD, IL13, IL3, IL4, IL5
43viral infectious disease15.2PIK3CG, PDE4A, RELA, KITLG, BTK, VIPR1
44churg-strauss syndrome15.1CHIA, MPO, IL10, IL13, IL2RA, IL4
45eosinophilic esophagitis15.0VCAM1, MUC5AC, FLG, IL10, IL13, IL5
46crohn's disease15.0BDKRB2, MUC2, T, MPO, FOXP3, IL10
47food allergy15.0FOXP3, IL13, IL4, IL5, CCL11, IGES
48cholangitis15.0KITLG, MUC2, MPO, CD28, CD79A, CD86
49onchocerciasis15.0IL10, IL13, IL4, IL5, CCL11, CCL5
50systemic lupus erythematosus14.9SELE, SERPINB1, VIP, VCAM1, BDNF, MPO

Graphical network of the top 20 diseases related to rhinitis:



Graphical network of diseases related to rhinitis

Clinical Features for Rhinitis

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Drugs & Therapeutics for Rhinitis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, naphazoline, naphazoline hydrochloride, oxymetazoline, oxymetazoline hydrochloride, phenylpropanolamine

Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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22MalaCards
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MalaCards organs/tissues related to rhinitis:

22
Bone marrow, Spleen, Thymus, Small intestine, Liver, Adrenal gland, Skin, Nk cells, T cells, B cells, Endothelial, Bronchial epithelium

Phenotypes for genes affiliated with Rhinitis

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25MGI
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MGI Mouse Phenotypes related to rhinitis:

25 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539711.7BTK, SERPINB1, BDKRB2, BCL2, UCHL1, CD28
2respiratory system phenotypeMP:000538811.0SFTPD, SELL, SERPINB1, BDNF, SCGB1A1, LGR5
3normal phenotypeMP:000287310.7RELA, SELE, SEPT3, VIP, VEGFA, BDKRB2
4immune system phenotypeMP:000538710.3PIK3CD, PDE4A, BTK, SELL, SERPINB1, VIPR2
5endocrine/exocrine gland phenotypeMP:000537910.2SELL, VIPR1, BDKRB2, LGR5, YBX2, CD40LG
6integument phenotypeMP:001077110.0PIK3CG, RELA, KITLG, BTK, BDNF, BCL2
7behavior/neurological phenotypeMP:00053869.9SELE, VIP, VIPR1, VIPR2, CLCN3, BDKRB2
8liver/biliary system phenotypeMP:00053709.9RETN, VEGFA, CLCN3, IL12RB2, IL1R1, IL6
9no phenotypic analysisMP:00030129.8PIK3CD, VEGFA, VCAM1, BDNF, LGR5, MUC1
10renal/urinary system phenotypeMP:00053679.8PDC, RENBP, CLCN3, BDKRB2, BCL2, SCGB1A1
11nervous system phenotypeMP:00036319.3PDC, PDE4A, RELA, KITLG, SEPT3, SERPINF1
12mortality/agingMP:00107689.2RELA, KITLG, SFTPD, BTK, SELE, SERPINE1
13adipose tissue phenotypeMP:00053759.2RETN, SERPINE1, VIPR2, CLCN3, BDKRB2, BCL2
14homeostasis/metabolism phenotypeMP:00053769.0PIK3CD, PIK3CG, PDC, RELA, RENBP, RETN
15reproductive system phenotypeMP:00053899.0SERPINF1, VIP, VIPR2, VEGFA, CLCN3, BDKRB2
16tumorigenesisMP:00020068.8KITLG, BTK, SELL, SERPINE1, BCL2, SCGB1A1
17growth/size phenotypeMP:00053788.7PIK3CG, RELA, KITLG, SFTPD, BTK, SELE
18digestive/alimentary phenotypeMP:00053818.7KITLG, BTK, SERPINF1, VIPR1, VEGFA, CLCN3
19skeleton phenotypeMP:00053908.4PIK3CD, PIK3CG, RELA, KITLG, VEGFA, CLCN3
20cellular phenotypeMP:00053847.8PIK3CD, PIK3CG, RELA, KITLG, BTK, SELE
21cardiovascular system phenotypeMP:00053857.6PIK3CD, PIK3CG, PDC, PDE4A, RELA, KITLG
22vision/eye phenotypeMP:00053917.5PDC, RELA, KITLG, SELE, SERPINF1, VEGFA
23muscle phenotypeMP:00053696.5PIK3CG, PDC, RELA, VEGFA, KDR, BCL2

Publications for genes affiliated with Rhinitis

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35PubMed
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Articles related to rhinitis:

(show top 50)    (show all 630)
idTitleAuthorsYearAffiliating Genes
1Forkhead box P3+ T cells express interleukin-17 in na sal mucosa of patients with both allergic rhinitis and polyposis. (21091665)Liu T.... Yang P.C.2011FOXP3, IL17A
2Peripheral Th-17 cells in allergic rhinitis: New evid ence. (19925886)Ciprandi G.... Fenoglio D.2010IL17A
3Local allergic rhinitis: a new entity, characterizati on and further studies. (20010094)RondA^n C.... Blanca M.2010RNASE3
4Expression and DNA binding activity of NF-kappaB p50 in nasal mucosal tissue of seasonal allergic rhinitis]. (20737960)Xue J.... Wei R.2010NFKB1
5Serum adiponectin levels in patients with seasonal al lergic rhinitis. (20188864)Ciprandi G.... Marseglia G.2010ADIPOQ
6FcI/RI levels and frequencies of peripheral blood dend ritic cell populations in allergic rhinitis. (20650300)Lundberg K.... Lindstedt M.2010FCGR1A
7Re-treatment with omalizumab at one year interval for Japanese cedar pollen-induced seasonal allergic rhinitis is effective and well tolerated. (19218816)Ogino S.... Ishikawa T.2009IGHE
8Futura study: evaluation of efficacy and safety of ru patadine fumarate in the treatment of persistent allergic rhinitis. (19893935)Mion O.d.e. .G.... Chavarria M.L.2009HRH1
9Vascular endothelial growth factor produced in nasal glands of perennial allergic rhinitis. (18702899)Matsune S.... Kurono Y.2008VEGFA
10Nasal mucosal expression of nitric oxide synthases in patients with allergic rhinitis and its relation to asthma. (18254476)Yuksel H.... Ozbilgin K.2008NOS2
11Specific IgE serum concentration is associated with symptom severity in children with seasonal allergic rhinitis. (18782113)Rolinck-Werninghaus C.... Hamelmann E.2008IGHE
12Significance of the examination of path between eosinophils in peripheral blood and marrow stem cells for evaluating the effect of hormone therapy in patients with allergic rhinitis (18826114)Zhang H.... Guo C.H.2008IL5
13Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. (18266897)Raap U.... Braunstahl G.J.2008NGF
14The Allergic Rhinitis and its Impact on Asthma system: a new classification of allergic rhinitis and nasal responsiveness. (17498329)Sheahan P.... Costello R.W.2008KNG1
15Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis (18260253)Gawlik R.... Jawor B.2007EDN1
16STAT1 is involved in the pathogenesis of murine allergic rhinitis. (17424888)Hattori H.... Satoskar A.R.2007STAT1
17Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. (17337294)RondA^n C.... Blanca M.2007IGHE
18Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma. (18047813)Erel F.... Karaayvaz M.2007LEP, LSL
19The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis (18254318)Chen J.... Tan H.2007IL10, IL13, IL16
20Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. (18219831)Vanhinsbergh L.J.... Jones N.S.2007TLR2, DEFA1, DEFB4A
21Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. (17298427)Benson M.... Cardell L.O.2007SCGB1A1
22Effects of topical formoterol alone and in combinatio n with budesonide in a pollen season model of allergic rhinitis. (17215115)AhlstrAPm Emanuelsson C.... Greiff L.2007RNASE3
23Neuronal markers in allergic rhinitis: expression and correlation with sensory testing. (17667132)O'Hanlon S.... Anand P.2007NGF
24The role of allergic rhinitis in nasal responses to sudden temperature changes. (17088139)Graudenz G.S.... Kalil J.2006RNASE3
25The expression of transforming growth factor beta1, interleukin-6, 11 and 17 in nasal mucosa of allergic rhinitis patients (17017182)Liu Z.... You X.2006TGFB1
26Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. (16008061)WedbAock A.... Malcus I.2005IGHE
27The expression of intercellular adhesion molecule-1 and interleukin-6 in nasal and bronchial mocosa in allergic rhinitis (15311501)Zhang Q.... Ji G.2004ICAM1
28Steroid-sensitive indices of airway inflammation in children with seasonal allergic rhinitis. (12603713)Meyer P.... Greiff L.2003CCL11, RNASE3
29Discriminant analysis in allergic rhinitis and asthma: methacholine dose-response slope allows a good differentiation between mild asthma and rhinitis. (12556008)Alvarez-Puebla M.J.... Olaguibel-Rivera J.M.2003IGHE
30Increased eosinophil transmigration after nasal allergen challenge in children with allergic asthma and rhinitis. (12464051)LAPnnkvist K.... Lundahl J.2002CCL11, IL5
31Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis. (14561202)Bochenek G.... Szczeklik A.2002PTGS1, LTC4S
32Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters. (11167349)Ventura M.T.... Tursi A.2001RNASE3
33Intranasal capsaicin is lacking therapeutic effect in perennial allergic rhinitis to house dust mite. A placebo-controlled study. (11122219)Gerth van Wijk R.... Popering S.2000ALB
34Phleum pratense-specific T cells of allergic rhinitis patients display a broader recognition pattern than phleum pratense-specific serum immunoglobulin E. (10651777)van Neerven R.J.... Ipsen H.2000IFNG, IL5, IGHE
35Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. (10768732)Benson M.... StrannegAYrd O.2000IFNG, IL5, RNASE3
36Eosinophil cationic protein (ECP) and tryptase in the nasal lavage fluid (NLF) of children with grass pollen rhinitis: levocabastine effect. (9578915)Bernardini R.... Vierucci A.1998RNASE3
37Rhinitis alone or rhinitis plus asthma: what makes the difference? (9863999)Magnan A.... Charpin D.1998IGHE, IGES
38Inflammatory mediators in naturally occurring rhinitis. (9515596)Wilson S.J.... Howarth P.H.1998ALB, RNASE3
39Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor. (9809497)Frieri M.... Sansone G.1998IL8, ALOX5
40A comparison of cytokine release from epithelial cells cultured from nasal biopsy specimens of atopic patients with and without rhinitis and nonatopic subjects without rhinitis. (9003213)CalderA^n M.A.... Davies R.J.1997TNF, IL1B, IL8
41Rhinitis and asthma: nasal provocation test in the diagnosis of asthma. (9416559)OlivAc PAcrez A.1997RNASE3
42Pathogenesis of allergic rhinitis. (9042069)Baraniuk J.N.1997IL3, IL4, CCL11
43The pharmacological basis for the treatment of perenn ial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. (9212861)Meltzer E.O.1997IL6, NR3C1, IFNG
44Determination of intercellular adhesion molecule-1 (ICAM-1) in nasal secretions of patients with rhinitis (9131919)BujA-a J.... Rasp G.1997ICAM1
45Increase in expression of IL-4 and IL-5 mRNA in the nasal mucosa of patients with perennial allergic rhinitis during natural allergen exposure. (9078933)Lee C.H.... Lee M.S.1997IL4, IL5
46Exudative hyperresponsiveness of the airway microcirc ulation in seasonal allergic rhinitis. (8556565)Svensson C.... Persson C.G.1995ALB
47The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis. (1382478)Montefort S.... Howarth P.H.1992ICAM1, SELE, VCAM1
48Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. (1741538)Sedgwick J.B.... Busse W.W.1991IL5
49Acrivastine. A review of its pharmacological properti es and therapeutic efficacy in allergic rhinitis, urticaria and related disorde rs. (1715267)Brogden R.N.... McTavish D.1991HRH1
50New perspectives on the pathogenesis of rhinitis (1688254)Cavallo G.P.... Cavallo R.1991IL4

Expression for genes affiliated with Rhinitis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Rhinitis

Pathways for genes affiliated with Rhinitis

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38Reactome, 20KEGG, 37R&D Systems, 36QIAGEN, 41Thomson Reuters, 10EMD Millipore
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Pathways related to rhinitis according to GeneDecks:

(show top 50)    (show all 193)
idPathwayScoreTop Affiliating Genes
1Immune System3811.5VCAM1, CD79A, CD40, FCGR1A, FCGR3A, IL18
2Asthma2011.3MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
3Jak-STAT signaling pathway2011.2PIK3CD, PIK3CG, LEP, IL10, IL12A, IL12B
4Th1 Differentiation3711.1JUN, CD28, CD86, CD4, IL10, IL12A
5Intestinal immune network for IgA production2011.1CD28, CD86, CD40LG, CD40, IL10, IL15
6THC Differentiation Pathway3611.0CD28, CD86, IL10, IL12A, IL12B, IL12RB1
7African trypanosomiasis2011.0SELE, VCAM1, IL10, IL12A, IL12B, IL18
8Cytokine Network3610.9IL10, IL12A, IL12B, IL13, IL15, IL16
9Transendothelial Migration of Leukocytes3610.9BTK, VCAM1, ITGAL, ITK, MMP9, IL8
10Measles2010.9PIK3CD, PIK3CG, RELA, CD28, CD3D, IRAK4
11Fc epsilon RI signaling pathway2010.8PIK3CD, PIK3CG, BTK, MS4A2, FCER1A, IL4
12JNK Pathway3610.8KITLG, BTK, KDR, BCL2, JUN, CD4
13Th17 Differentiation3710.8CD28, CD86, CD4, IL12B, IL12RB1, IL17A
14Tuberculosis2010.8RELA, BCL2, CD14, IRAK4, FCGR1A, FCGR2A
15Bacterial infections in CF airways4110.7RELA, SFTPA1, SFTPD, MUC1, IRAK4, IL1R1
16T cell receptor signaling pathway2010.7PIK3CD, PIK3CG, RELA, JUN, CD28, CD3D
17Graft-versus-host disease2010.7CD28, CD86, IL1A, HLA-A, HLA-B, HLA-C
18Akt Signaling3610.7PIP, PIK3CG, BTK, CD28, CD4, ITGAL
19Immune response MIF-mediated glucocorticoid regulation1010.6RELA, VCAM1, JUN, IL6, IL8, MAPK1
20Cytokine production by Th17 cells in CF (Mouse model)4110.6RELA, CD14, FOXP3, IL12B, IL12RB1, IL17A
21Allograft rejection2010.5CD28, CD86, CD40LG, CD40, IL10, IL12A
22Glucocorticoid Receptor Signaling3610.5BTK, BCL2, JUN, CD4, IL10, IL12A
23Leishmaniasis2010.5RELA, JUN, IRAK4, FCGR1A, FCGR2A, FCGR3A
24Endothelin-1 Signaling Pathway3610.5PIP, BTK, IL10, IL12A, IL12B, IL13
25IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.5IL12B, IL17A, IL1B, IL23A, IL4, IL4R
26Chemokine signaling pathway2010.5PIK3CD, PIK3CG, RELA, ITK, IL8, MAPK1
27Immune response IL-22 signaling pathway1010.4BCL2, JUN, CD28, CD86, CD4, IL12A
28Immune response_IL-22 signaling pathway4110.4BCL2, JUN, CD28, CD86, CD4, IL12A
29ERK Signaling3610.4PIP, KITLG, BTK, CD3D, ITGAL, IL10
30Type I diabetes mellitus2010.3CD28, CD86, IL12A, IL12B, IL1A, IL1B
31STAT3 Pathway3610.2PIP, BTK, BCL2, CD28, CD4, IL10
32Immune response IL-1 signaling pathway1010.2RELA, SERPINE1, JUN, IRAK4, IL1A, IL1B
33Immune response_IL-1 signaling pathway4110.2RELA, SERPINE1, JUN, IRAK4, IL1A, IL1B
34NFAT in Immune Response3610.2KITLG, BTK, BDNF, KDR, JUN, CD28
35RAR-Gamma-RXR-Alpha Degradation3610.2PIP, BTK, IL12A, IL15, IL16, IL23A
36NF-KappaB (p50-p65) Pathway3610.1RELA, KITLG, BDNF, KDR, IRAK4, IL1A
37Chemokine Signaling3610.1JUN, IL8, MAPK14, MAPK1, CCL8, CCL4
38NF-KappaB Family Pathway3610.0RELA, KITLG, BDNF, KDR, IRAK4, IL1A
39Toll-like receptor signaling pathway2010.0PIK3CD, PIK3CG, RELA, JUN, CD86, CD14
40Rheumatoid arthritis209.9VEGFA, JUN, CD28, CD86, ITGAL, IL15
41TGF-Beta Pathway369.9KITLG, BTK, BDNF, KDR, BCL2, JUN
42Osteoclast differentiation209.9PIK3CD, PIK3CG, RELA, BTK, JUN, FCGR1A
43IL-6 Pathway369.8PIP, BTK, IL10, IL12A, IL12B, IL16
44MIF Mediated Glucocorticoid Regulation369.7PIP, BTK, BCL2, CD14, IL10, IL12A
45Hematopoietic cell lineage209.7KITLG, CD3D, CD14, CD4, MME, FCER2
46PEDF Induced Signaling369.6PIP, RELA, BTK, SERPINF1, BDNF, BCL2
47all-trans-Retinoic Acid Signaling in Brain369.6PIP, BTK, BCL2, IL10, IL12A, IL12B
48Influenza A209.5PIK3CD, PIK3CG, RELA, JUN, IRAK4, IL12A
49Antioxidant Action of Vitamin-C369.2PIP, KITLG, BTK, BDNF, KDR, BCL2
50Rho Family GTPases369.1PIP, KITLG, BTK, BDNF, KDR, BCL2

Compounds for genes affiliated with Rhinitis

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
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Compounds related to rhinitis according to GeneDecks:

(show top 50)    (show all 481)
idCompoundScoreTop Affiliating Genes
1methacholine32 9 9 14.6VIP, MPO, CD79A, CD14, MME, IL13
2calcium32 9 18 9 15.3PIK3CD, PDC, PDE4A, RELA, RETN, KITLG
3ltc432 11.9VIP, IL13, IL3, IL5, CCL11, ALOX5
4cyclic amp32 18 12.8PDC, PDE4A, SFTPD, BDKRB2, BDNF, SCG2
5salbutamol32 34 9 18 9 15.6PDE4A, KITLG, VIP, VCAM1, CHKB, CD79A
6forskolin32 42 9 9 14.3PDE4A, RETN, VIP, VIPR1, BDKRB2, BDNF
7hyaluronic acid32 18 12.2SCGB1A1, MUC1, LCN1, ITGAL, IL13, PTGS1
8nitric oxide32 9 18 9 14.1PDE4A, RETN, KITLG, SFTPD, SELE, SERPINF1
9ng-nitro-l-arginine32 11.1PDE4A, VIP, BDKRB2, BDNF, CALCA, NOS1
10pentoxifylline32 9 9 13.1PDE4A, SELL, VCAM1, MPO, CD14, IL10
11pranlukast32 9 9 13.1MUC2, IL4, IL5, CCL11, CCL5, ALOX5
12apocynin32 11.0SELE, VCAM1, MPO, JUN, ICAM1, DYT10
13glucose32 10.9PDE4A, SERPINF1, VIPR1, SCG2, CFD, MME
14aprotinin32 9 9 12.9VIP, BDKRB2, MMP9, IL1A, IGHE, PPBP
15sp 60012532 42 11.9PIK3CG, VCAM1, CD40, IL13, IL17A, AKT1
16agarose32 10.8KITLG, SFTPD, BCL2, CHKB, MUC1, MUC2
17histamine32 18 11.8PDE4A, KITLG, SFTPD, BTK, SELE, SELL
185-hydroxytryptamine32 10.7BTK, SERPINE1, VIP, SCG2, MME, IL1A
19leflunomide32 9 9 12.6BTK, IL13, IL15, IL18R1, IL1R1, IL1RN
20atp32 10.6PDE4A, RENBP, BTK, CLCA1, BDKRB2, BDNF
21oxygen32 18 11.6KITLG, SFTPD, SERPINF1, BDNF, BCL2, SCGB1A1
22mannose32 10.5SFTPD, CLC, PAPPA, CHIT1, CD79A, CD86
23adenylate32 10.4PIK3CG, PDC, PDE4A, KITLG, SELE, SERPINE1
24rituximab32 34 9 9 13.4BCL2, CD79A, CD40LG, CD40, FCGR1A, FCGR2A
25infliximab32 9 9 12.4SELE, VEGFA, BGLAP, FLG, IL10, IL15
26nmda32 42 11.3PDE4A, BDNF, LEP, IL18R1, IL1A, IL1R1
27arginine32 10.3PDC, PDE4A, BTK, VIP, BGLAP, BDKRB2
28pertussis32 10.2PIK3CG, VIP, JUN, ITGAL, MAPK1, CCL22
29cholesterol32 9 18 9 13.2RETN, KITLG, SFTPD, SELE, SERPINE1, VCAM1
30ivig32 10.2BTK, FCGR1A, FCGR3A, IL18R1, IL1RAPL2, IL3
31anaphylatoxin32 10.2VIP, MPO, IL1B, IL3, IL4, IL6
32fenofibrate32 9 9 12.1RETN, SELE, SERPINE1, VCAM1, LEP, CD40LG
33calcitriol32 42 9 18 9 14.1KITLG, BGLAP, JUN, CD14, ITGAL, FLG
34endotoxin32 10.0RETN, SFTPD, SELL, SCGB1A1, CHKB, CD86
35ag 147832 9.9PIK3CG, SERPINE1, MUC5AC, JUN, MMP9, IL8
36cyclosporin a32 42 10.8PIK3CG, PDE4A, KITLG, VIP, BGLAP, LEP
37tacrolimus32 34 9 9 12.7SERPINE1, CHKB, CD28, CD79A, CD86, CD40
38ns 39832 42 10.7PIK3CG, BGLAP, IL17A, IL1A, IL1B, IL8
39sb 20358032 42 10.6BTK, SELE, VEGFA, VCAM1, BGLAP, BCL2
40curcumin32 9.6PIK3CG, VEGFA, VCAM1, BCL2, JUN, MMP9
41prostacyclin32 9.5PDE4A, SELE, SERPINE1, VIP, VEGFA, VCAM1
42phorbol32 9.4SELL, JUN, CD4, CD40, ITGAL, MMP9
43sulfasalazine32 9 9 11.2SELE, MPO, CD79A, CD40LG, IL12B, IL1A
44candesartan32 9 9 11.2SERPINE1, VEGFA, BDKRB2, CCL2, ALB, PTGS1
45matrigel32 9.1PIK3CG, SELE, SERPINF1, SERPINE1, VEGFA, VCAM1
46gm-csf32 9.1KITLG, VEGFA, CD14, IL10, IL13, IL15
47celecoxib32 42 34 9 18 9 13.9PIK3CG, VEGFA, KDR, BCL2, MMP9, IL1B
48cysteine32 8.7RENBP, SFTPD, BTK, SERPINF1, CMA1, BGLAP
49doxorubicin32 34 9 9 11.5PIK3CG, KITLG, SELE, BDNF, KDR, CD40LG
50cisplatin32 34 9 9 11.1KITLG, VEGFA, BGLAP, BDNF, KDR, BCL2

GO Terms for genes affiliated with Rhinitis

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Sources:
12Gene Ontology
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Cellular components related to rhinitis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.6TLR4, ADRB2, TGFBR3, TACR1, CX3CR1, CXCR2
2external side of plasma membraneGO:00989711.3KDR, MS4A2, CD28, CD79A, CD86, CD4
3plasma membraneGO:00588610.4HMOX2, PTGS1, TBXA2R, DMPK, CYSLTR2, CYSLTR1
4ER to Golgi transport vesicle membraneGO:01250710.4HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
5integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
6cell surfaceGO:00998610.1TLR3, TLR2, ELANE, NGFR, TGFA, TGFB1
7platelet alpha granule lumenGO:03109310.1KNG1, TGFB1, TIMP1, PF4, PPBP, ALB
8extracellular regionGO:00557610.0APOA4, ALB, CALCA, HLA-C, PTGDS, SPP1
9extracellular spaceGO:0056159.5PMCH, NPY, CP, WNT2B, KNG1, ADM

Biological processes related to rhinitis according to GeneDecks:

(show top 50)    (show all 90)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695512.0VIPR1, CHIT1, CHIA, CD86, CD4, FCGR1A
2elevation of cytosolic calcium ion concentrationGO:00720411.5CCR3, F2RL1, CALCA, TBXA2R, CYSLTR1, EDN1
3inflammatory responseGO:00695411.5IL6, CCR3, CCL24, CCL13, CCL5, F2RL1
4positive regulation of tumor necrosis factor productionGO:03276011.4TLR9, TLR4, TLR3, TLR2, PF4, NOD2
5eosinophil chemotaxisGO:04824511.2CCL11, CCL5, CCL24, CCL13, SCG2, CCL7
6defense response to bacteriumGO:04274211.1TLR4, CCL20, NOS2, RNASE3, LTF, TLR3
7positive regulation of vasoconstrictionGO:04590711.1PTGS2, PTGS1, TBXA2R, CYSLTR1, PDE5A, ALOX5
8positive regulation of T cell proliferationGO:04210211.1IFNG, ITGAL, CCL5, IL6, IL4, IL23A
9positive regulation of interleukin-12 productionGO:03273511.0CD40LG, TLR3, TLR9, IL12B, IL23A, IFNG
10positive regulation of NF-kappaB transcription factor activityGO:05109211.0CD40, BTK, RELA, TLR3, TLR2, AGT
11cell-cell signalingGO:00726711.0IL10, IL13, IL15, IL17A, IL18, IL1B
12interferon-gamma-mediated signaling pathwayGO:06033311.0HLA-DRB1, STAT1, HLA-DQA1, HLA-B, HLA-C, VCAM1
13positive regulation of interleukin-8 productionGO:03275710.9CALCA, ADIPOQ, TLR9, TLR4, TLR3, TLR2
14positive regulation of nitric oxide biosynthetic processGO:04542910.9TLR2, IL1B, IFNG, ICAM1, HRH1, AKT1
15positive regulation of inflammatory responseGO:05072910.9AGT, EDNRA, PLA2G2A, PLA2G7, CCL24, IL33
16response to lipopolysaccharideGO:03249610.8PDE5A, ELANE, TAC1, EDN1, TLR4, ADM
17positive regulation of interferon-gamma productionGO:03272910.8IL1B, IL12RB1, TLR4, TNF, IL23A, IL18
18chemotaxisGO:00693510.8CCL22, CCL2, PLAU, RNASE2, TYMP, CCL26
19positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5VEGFA, IL6, IL5, IL3, FCER1A, CD4
20cellular calcium ion homeostasisGO:00687410.5CCL2, CCL7, CCL8, CD40, CCL13, CCL1
21positive regulation of interleukin-6 productionGO:03275510.4IL6, TNF, NOD1, NOD2, TLR2, TLR3
22cell surface receptor signaling pathwayGO:00716610.4EDN1, TRPV1, BDKRB2, EGFR, CXCR1, CXCR2
23cellular response to lipopolysaccharideGO:07122210.3NOS2, TLR4, CX3CR1, SERPINE1, IL12B, CD14
24Toll signaling pathwayGO:00806310.3CD14, IRAK4, MAPK1, MAPK14, NOD2, TLR3
25response to ethanolGO:04547110.2SOD1, GATA3, PRKCA, ADIPOQ, BGLAP, BCL2
26response to drugGO:04249310.2CCL2, IFNG, ICAM1, TRPA1, TNF, PTGS2
27G-protein coupled receptor signaling pathwayGO:00718610.2EDNRA, VIPR1, PDC, AGT, DEFB4A, CX3CR1
28toll-like receptor 4 signaling pathwayGO:03414210.1CD14, TLR3, IRAK4, TLR2, NFKB1, NOD2
29lipopolysaccharide-mediated signaling pathwayGO:03166310.1TLR4, STAT1, TGFB1, CCL2, IL18, IL1B
30innate immune responseGO:04508710.1PIK3CD, MBL2, MAPK14, MAPK1, F2RL1, NOD1
31agingGO:00756810.1IL15, IL1B, ADM, PRKCA, TIMP1, AGT
32platelet activationGO:03016810.0TIMP1, VEGFA, CFD, CD40LG, TF, SYK
33cytokine-mediated signaling pathwayGO:01922110.0VCAM1, IRAK4, FCGR1A, IL12RB1, IL12RB2, IL13RA2
34neutrophil chemotaxisGO:03059310.0IFNG, IL8, IL1B, SYK, C5AR1, CXCR2
35positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0TLR4, TLR2, NOD2, CCL2, FCER2, KDR
36response to glucocorticoid stimulusGO:05138410.0ADM, IL1B, SERPINF1, ADIPOQ, IL10, SERPINE1
37humoral immune responseGO:0069599.9LTF, TNF, IFNG, CCL2, IL6, IL7
38response to heatGO:0094089.9CCL2, CALCA, AKT1, SOD1, OSM, NOS1
39signal transductionGO:0071659.8FCGR1A, CCL2, CCL11, CCL20, CCL1, CCL24
40blood coagulationGO:0075969.8NOS2, SERPINE1, PIK3CG, VEGFA, CFD, ITGAL
41positive regulation of transcription from RNA polymerase II promoterGO:0459449.8FOXP3, FOXJ1, IL1B, RELA, SERPINE1, VEGFA
42negative regulation of apoptotic processGO:0430669.8PIK3CG, EDNRA, SERPINE1, CSF2, CX3CR1, CX3CL1
43positive regulation of cell proliferationGO:0082849.7VIP, VIPR1, VEGFA, KDR, LEP, TGFBR2
44positive regulation of smooth muscle cell proliferationGO:0486619.7EDN1, JUN, IRAK4, IL13, IL6, CCL5
45positive regulation of chemokine productionGO:0327229.7TLR3, TLR9, TLR4, TLR2, HIF1A, IL18
46anti-apoptosisGO:0069169.6AKT1, IL10, CCL2, NGF, IL1A, NGFR
47cellular response to interleukin-1GO:0713479.5EDN1, NFKB1, ICAM1, CCL5, CCL2, IL8
48positive regulation of angiogenesisGO:0457669.5CCL11, IL1B, IL1A, MMP9, KDR, VEGFA
49angiogenesisGO:0015258.8KDR, MAPK14, IL8, IL18, PIK3CG, JUN
50response to hypoxiaGO:0016668.7VCAM1, VEGFA, BCL2, LEP, MMP9, HMOX2

Molecular functions related to rhinitis according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.5EGFR, TLR2, TLR3, TLR4, SLAMF1, NGFR
2chemokine activityGO:00800910.4CX3CL1, PF4, PPBP, CCL5, CCL14, CCL13
3heparin bindingGO:00820110.1LTF, ABP1, ELANE, TGFBR3, PRG2, KNG1
4protein homodimerization activityGO:04280310.0NOD1, NOS2, NFKB1, ABP1, TGFB1, TAP1
5receptor bindingGO:0051029.7HLA-G, NTF3, NOS2, PFN1, CX3CL1, NPY
6cytokine activityGO:0051259.4KITLG, IL33, IL31, IL3, IL23A, IL1B
7growth factor activityGO:0080839.1CSF1, OSM, TGFB1, TGFA, TYMP, AGT
8protein bindingGO:0055157.7NGFR, NLRP3, NOS2, NOS1, NOD2, NFKB1

Sources for Rhinitis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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