MCID: RHN004
MIFTS: 65

Rhinitis malady

Respiratory diseases category
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Summaries for Rhinitis

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Disease Ontology:8 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards based summary: Rhinitis, also known as rhinitis, nos, is related to asthma and vasomotor rhinitis. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs hyoscyamine sulfate and ephedrine and the compounds ltc4 and praziquantel have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:65 Rhinitis /ra??na?t?s/ or coryza is irritation and inflammation of the mucous membrane inside the nose.... more...

Aliases & Classifications for Rhinitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT
See all sources

Rhinitis, Aliases & Descriptions:

Name: Rhinitis 8 10 44 62
 
Rhinitis, Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:4483
MeSH34 D012220
SNOMED-CT57 70076002
NCIt39 C34986

Related Diseases for Rhinitis

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Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.3CCL11, IL13
2vasomotor rhinitis32.2RNASE3, VIP
3chronic rhinitis32.0RNASE3, HRH1
4sinusitis31.2CCL11, RNASE3, IGHE, IL5
5conjunctivitis31.2HRH1, RNASE3, IGHE
6otitis media30.9IGHE, RNASE3, CCL11
7allergic bronchopulmonary aspergillosis30.5IGHE, IL5, IL4
8mastocytosis30.5IL13, IGHE, IL5
9urticaria30.4FCER2, KNG1, HRH1, RNASE3, IGHE
10anisakiasis30.4IGHE, RNASE3
11common cold30.3IL8, ICAM1, RNASE3, CCL11
12giant papillary conjunctivitis30.3RNASE3, CCL11, IL5
13keratoconjunctivitis30.2IL5, IL13, CCL11, RNASE3
14allergic conjunctivitis30.2IGHE, RNASE3, CCL11, IL4, IL5, IL13
15dermatitis30.2IL13, IL5, IL4, CCL11, ICAM1, IGHE
16churg-strauss syndrome30.1IL5, RNASE3, MPO
17intrinsic asthma29.8RNASE3, IL5, IL4, FCER2, IGHE
18food allergy29.8IL5, IL4, CCL11, EPX, RNASE3, IGHE
19atopy29.8IL13, IL4R, IL5, IGHE, MPO, FCER2
20cystic fibrosis29.7IL8, VIP, RNASE3, MPO
21chronic lymphocytic leukemia29.7FCER2, ICAM1, IL4
22bronchiectasis29.6IGHE, IL8, RNASE3, MPO
23graves' disease29.5IL4R, IL4, MPO, IL13, ICAM1
24chronic obstructive pulmonary disease29.5IL8, CCL11, MPO, IL13, RNASE3
25pneumonia29.3HRH1, KNG1, IL13, IL5, CCL11, ICAM1
26allergic rhinitis29.2CCL11, RNASE3, EPX, VIP, ICAM1, HRH1
27eosinophilia29.0IGHE, NGF, MPO, IL13, IL8, IL5
28allergic asthma28.8FCER2, NGF, IGHE, RNASE3, EPX, ICAM1
29leukemia28.7RNASE3, EPX, NGF, MPO, CCL11, IL4
30vernal keratoconjunctivitis28.6IL13, IL8, IL5, IL4, CCL11, ICAM1
31atopic dermatitis28.2IGHE, NGF, FCER2, RNASE3, EPX, VIP
32atrophic rhinitis11.2
33blindness10.6
34folliculitis10.6CCL11
35bronchitis10.6RNASE3
36collagenous colitis10.5RNASE3
37eosinophil peroxidase deficiency10.5EPX
38impotence10.5VIP
39cystitis10.5NGF
40eosinophilic esophagitis10.4CCL11, IL5
41corneal ulcer10.4CCL11, NGF
42mononeuropathy10.4MPO
43paragonimiasis10.4IL5, IGHE
44toxocariasis10.4IGHE, RNASE3
45pulpitis10.4KNG1
46strongyloidiasis10.4IGHE, IL5
47nephrotic syndrome10.4CCL11, IL13, IL4R
48proctitis10.3RNASE3, EPX
49esophagitis10.3CCL11, IL5, IL13
50contact dermatitis10.3IL5, IGHE

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Symptoms for Rhinitis

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Drugs & Therapeutics for Rhinitis

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Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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MalaCards organs/tissues related to Rhinitis:

32
Testes, Eye, T cells, Skin, Bone, Lung, Neutrophil, B cells, Endothelial, Heart, Colon, Liver, Thyroid, Tonsil, Bone marrow, Lymph node, Spleen, Thymus, Salivary gland, Monocytes, Nk cells

Animal Models for Rhinitis or affiliated genes

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MGI Mouse Phenotypes related to Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5VIP, CCL11, IL4, IL5, IL4R, IL13
2MP:00053818.2IL13, IL4R, IL5, IL4, ICAM1, FCER2
3MP:00053787.6HRH1, IL13, IL4R, IL5, FOXJ1, ICAM1
4MP:00107687.1FCER2, VIP, ADH5, ICAM1, FOXJ1, IL4
5MP:00053976.2IGHE, HRH1, EPX, ICAM1, CCL11, MPO
6MP:00053766.0IGHE, NGF, MPO, FCER2, HRH1, KNG1
7MP:00053875.7FCER2, IGHE, EPX, VIP, ADH5, HRH1

Publications for Rhinitis

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Articles related to Rhinitis:

(show top 50)    (show all 2052)
idTitleAuthorsYear
1
Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study. (25363381)
2014
2
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
3
Seroprevalence study of Equine rhinitis B virus (ERBV) in Australian weanling horses using serotype-specific ERBV enzyme-linked immunosorbent assays. (23960171)
2013
4
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
5
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
6
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
7
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
8
Effect of intranasal azelastine on substance P release in perennial nonallergic rhinitis patients. (24274229)
2013
9
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
10
Nasal mucosa temperature as a marker of disease in children with allergic rhinitis. (22801008)
2012
11
Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. (22411430)
2012
12
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
13
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
14
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
15
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
16
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
17
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
18
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
19
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
20
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
21
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
22
How safe are the biologicals in treating asthma and rhinitis? (20016776)
2009
23
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
24
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
25
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
26
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
27
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
28
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
29
Transforming growth factor-alpha and rhinitis. (10401853)
1999
30
Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. (10543283)
1999
31
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
32
Endoscopic sinus surgery and postoperative intravenous aminoglycosides in the treatment of atrophic rhinitis. (9805532)
1998
33
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
34
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
35
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
36
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
37
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993
38
Reopening of the closed nostril in atrophic rhinitis. (3397634)
1988
39
Nasal histamine and heparin in chronic rhinitis. (3408114)
1988
40
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
41
Atrophic rhinitis in swine: correlation of Pasteurella multocida pathogenicity with membrane protein and lipopolysaccharide patterns. (6480114)
1984
42
Cryosurgery on postganglionic fibers (posterior nasal branches) of the pterygopalatine ganglion for vasomotor rhinitis. (6613543)
1983
43
The ozena problem. Clinical analysis of atrophic rhinitis in 100 cases. (7102303)
1982
44
Experimental atrophic rhinitis in gnotobiotic pigs. (7448626)
1980
45
Double-blind comparison of metizoline hydrochloride (Ellsyl) and phenylephrine in allergic and vasomotor rhinitis. (49255)
1975
46
Vidian neurectomy in vasomotor rhinitis. (4771966)
1973
47
Clinical and immunologic studies on fetid atrophic rhinitis (ozena) of the nasopharyngeal cavity treated with a specific vaccine. (4771981)
1973
48
Histopathological and histochemical studies on atrophic rhinitis. (5476397)
1970
49
Vasomotor rhinitis. (14388570)
1955
50
The management of vasomotor rhinitis. (18894292)
1948

Variations for Rhinitis

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Expression for genes affiliated with Rhinitis

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Expression patterns in normal tissues for genes affiliated with Rhinitis

Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

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Pathways related to Rhinitis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL4, IL4R
29.7IL13, IL5, IL4
39.7IL4, IL5, IL13
49.7IL4, IL5, IL4R
59.7IL13, IL8, NGF
69.6ICAM1, MPO
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.6IL8, IL4, CCL11
89.5IL4, IL5, IL4R, IL13
9
Show member pathways
9.5IL4, IL5, IL4R, IL13
10
Show member pathways
Type III interferon signaling37
9.5IL13, IL4R, IL5, IL4
11
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5IL8, IL5, IL4
12
Show member pathways
9.5IL8, CCL11, ICAM1
139.4IL8, IL4, ICAM1
149.4FCER2, IL4, IL5, IL4R
159.3KNG1, ICAM1, MPO
169.3IL4, IL5, IL8, IL13
179.3IL8, IL5, IL4, CCL11
18
Show member pathways
9.2ICAM1, IL4, IL8, IL13
19
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.2IGHE, IL4, IL5, IL13
208.9IL13, IL8, IL5, IL4, ICAM1
21
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
8.9IGHE, FCER2, CCL11, IL4, IL4R
22
Show member pathways
8.9CCL11, IL4, IL5, IL4R, IL8, IL13
23
Show member pathways
8.9CCL11, IL4, IL5, IL4R, IL8, IL13
24
Show member pathways
8.9IL13, IL8, IL4R, IL5, IL4, CCL11
25
Show member pathways
8.9CCL11, IL13, IL8, IL4R, IL5, IL4
268.6IGHE, FCER2, CCL11, IL4, IL5, IL4R
27
Show member pathways
8.5FCER2, CCL11, IL4, IL5, IL4R, IL8
28
Show member pathways
8.4IL13, RNASE3, EPX, ICAM1, CCL11, IL4
29
Show member pathways
7.9NGF, FCER2, VIP, CCL11, IL8, KNG1

Compounds for genes affiliated with Rhinitis

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Compounds related to Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 242)
idCompoundScoreTop Affiliating Genes
1ltc4449.4RNASE3, EPX, VIP, IL13, IL5, CCL11
2praziquantel44 1110.2IL13, IL4, IL5, RNASE3, IGHE
3unicap449.1IGHE, IL5, CCL11, RNASE3
4pgd2449.1RNASE3, IL5, CCL11, IGHE, EPX, IL13
5salmeterol44 50 28 1112.0IL13, IL8, IL5, IL4, CCL11, EPX
6levocetirizine448.9CCL11, IL4, IL8, HRH1
7omalizumab44 119.9IGHE, IL13, IL5, IL4
8rolipram44 61 2810.9IL4, IL5, CCL11, EPX, IL8, KNG1
9n-formylmethionyl-leucylphenylalanine448.8MPO, ICAM1, IL5, RNASE3, CCL11, IL8
10montelukast44 50 28 1111.8IL13, IL8, IL5, IL4, CCL11, RNASE3
11ionomycin448.7KNG1, IL13, IL5, IL4, CCL11, IL4R
12ltd4448.7IL5, IL13, KNG1, HRH1, RNASE3, VIP
13anti-histamine448.6RNASE3, IGHE, HRH1, CCL11, ICAM1
14herbimycin a44 619.5NGF, FCER2, CCL11, IL4, ICAM1, IL5
15sb 20358044 619.5IL13, CCL11, IL4, NGF, FCER2, ICAM1
16loratadine44 24 1110.4RNASE3, ICAM1, IL8, HRH1, IGHE
17tarc448.4IL4, CCL11, ICAM1, IGHE, IL5, IL4R
18fluticasone propionate44 50 61 1111.3MPO, IGHE, RNASE3, IL5, IL4, IL13
19azelastine44 119.3IL5, HRH1, IL4, ICAM1, RNASE3, IGHE
20erythromycin44 2 50 1111.3MPO, IL8, IL13, HRH1, IL5, VIP
21desloratadine44 119.3HRH1, IL13, IL8, IL4, ICAM1, IGHE
22prednisolone44 28 1110.3NGF, MPO, RNASE3, EPX, VIP, CCL11
23salbutamol44 50 28 24 1112.2IL13, IL8, IL5, CCL11, VIP, EPX
24ketotifen44 119.2HRH1, IL5, CCL11, IGHE, RNASE3, EPX
25capsaicin44 289.2NGF, IL5, RNASE3, IGHE, HRH1, KNG1
26leukotriene b444 61 2410.2EPX, CCL11, IL5, IL8, IL13, KNG1
27sodium cromoglycate448.2HRH1, IL5, CCL11, ICAM1, EPX, RNASE3
28fmlp448.1IL13, IL8, IL5, MPO, FCER2, RNASE3
29actinomycin d448.0IL4, IL4R, IL8, CCL11, ICAM1, NGF
30thymidine44 248.9IL4R, NGF, HRH1, IL13, IL5, IL4
31isoproterenol44 118.9HRH1, KNG1, IL13, IL4, VIP, IGHE
32heparin44 28 24 1110.8IL13, IL8, IL5, CCL11, EPX, KNG1
33lactate447.7IL8, IL13, RNASE3, FCER2, ICAM1, VIP
34cycloheximide447.7FCER2, KNG1, IL13, IL5, IL8, IL4R
35budesonide44 50 119.6IL13, IL8, IL5, IL4, CCL11, ICAM1
36rantes447.6HRH1, IL13, RNASE3, VIP, ICAM1, CCL11
37nedocromil sodium447.6HRH1, IL8, IL5, IL4, ICAM1, RNASE3
38allergens447.5IL4R, IL5, IL4, CCL11, EPX, RNASE3
39adenylate447.5KNG1, IL5, IL4, HRH1, NGF, RNASE3
40cetirizine44 28 24 1110.5CCL11, ICAM1, EPX, RNASE3, IGHE, IL5
41retinoic acid44 248.4IGHE, NGF, MPO, RNASE3, ADH5, CCL11
42vegf447.4NGF, MPO, RNASE3, VIP, ICAM1, IL8
43methacholine44 50 119.4IGHE, MPO, RNASE3, VIP, ICAM1, CCL11
44indomethacin44 28 61 1110.3IL4, IL5, IL13, KNG1, HRH1, CCL11
45tyrosine447.3CCL11, IL5, IL4R, IL13, KNG1, IL4
46cyclosporin a44 28 618.9IGHE, NGF, RNASE3, VIP, ICAM1, CCL11
47nitric oxide44 24 118.7RNASE3, KNG1, HRH1, IL13, IL8, CCL11
48pge2446.4VIP, EPX, ICAM1, CCL11, IL4, IL5
49dexamethasone44 50 28 119.2IGHE, NGF, FCER2, RNASE3, VIP, ICAM1
50histamine44 28 247.5VIP, ICAM1, CCL11, IL4, IL5, IL4R

GO Terms for genes affiliated with Rhinitis

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Cellular components related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL13, IL4, ICAM1, FCER2
2extracellular spaceGO:0056157.7IL4R, IL8, IL5, IL4, CCL11, ICAM1
3extracellular regionGO:0055767.5KNG1, IGHE, IL13, IL8, IL5, CCL11

Biological processes related to Rhinitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:04303210.2IL13, IL4R
2regulation of proton transportGO:01015510.2IL4, IL13
3defense response to protozoanGO:04283210.0IL4, IL4R
4positive regulation of B cell proliferationGO:03089010.0IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8IL4, NGF, IL5
6response to ethanolGO:0454719.8ICAM1, IL4, IL13
7eosinophil chemotaxisGO:0482459.7CCL11, HRH1
8hydrogen peroxide catabolic processGO:0427449.6MPO, EPX
9response to lipopolysaccharideGO:0324969.6ADH5, IL13, NGF, MPO
10chemotaxisGO:0069359.6CCL11, IL8, IL4
11negative regulation of apoptotic processGO:0430669.2MPO, VIP, IL4, NGF
12positive regulation of vasoconstrictionGO:0459079.0HRH1, ICAM1
13immune responseGO:0069558.6IL4, CCL11, IGHE, IL5, IL4R, IL8
14inflammatory responseGO:0069548.3IL13, NGF, CCL11, IL5, IL8, KNG1

Molecular functions related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.7IL13, IL5, IL4
2peroxidase activityGO:0046019.6EPX, MPO
3growth factor activityGO:0080839.4IL5, IL4, NGF

Products for genes affiliated with Rhinitis

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  • Antibodies
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Sources for Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet