MCID: RHN004
MIFTS: 65

Rhinitis malady

Summaries for Rhinitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards: Rhinitis, also known as rhinitis, nos, is related to allergic rhinitis and asthma. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are Signaling by GPCR and Allograft rejection. The drugs hyoscyamine sulfate and ephedrine and the compounds histamine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:63 Rhinitis /raɪˈnaɪtɪs/ or coryza is irritation and inflammation of the mucous membrane inside the... more...

Aliases & Classifications for Rhinitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

rhinitis 8 10 44 60
rhinitis, nos 8


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Disease Ontology8 DOID:4483
NCIt39 C34986
SNOMED-CT56 70076002
MeSH34 D012220

Related Diseases for Rhinitis

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17GeneCards, 18GeneDecks
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Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1allergic rhinitis32.0FCER2, HRH1, IL8, IL4, IL4R, IL5
2asthma31.5IL13, CCL11
3vasomotor rhinitis31.5RNASE3, VIP
4chronic rhinitis31.4HRH1, RNASE3
5allergic asthma31.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
6pneumonia30.7HRH1, IL8, IL5, IL13, EPX, KNG1
7eosinophilia30.7VCAM1, FCER2, IL8, IL4, IL5, IL13
8conjunctivitis30.6HRH1, RNASE3, IGHE
9allergic conjunctivitis30.6HRH1, IL4, IL5, IL13, RNASE3, IGHE
10urticaria30.5FCER2, HRH1, RNASE3, IGHE, KNG1
11dermatitis30.4VCAM1, IL4, IL5, IL13, IGHE, ICAM1
12common cold30.4IL8, RNASE3, ICAM1, CCL11
13atopic dermatitis30.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
14otitis media30.3RNASE3, IGHE, CCL11
15allergic bronchopulmonary aspergillosis30.1IL4, IL5, IGHE
16migraine30.1VIP
17leukemia29.9FCER2, HRH1, IL4, IL4R, RNASE3, EPX
18food allergy29.9IL4, IL5, IL13, RNASE3, EPX, IGHE
19intrinsic asthma29.9FCER2, IL4, IL5, RNASE3, IGHE
20cystic fibrosis29.9IL8, RNASE3, MPO, VIP
21tuberculosis29.9IL4, IL4R, EPX
22chronic fatigue syndrome29.9VIP
23wegener's granulomatosis29.9MPO
24skin disease29.7FCER2, HRH1, IL8, IL4, IL5, IL13
25graves' disease29.7VCAM1, IL4, IL4R, IL13, MPO, ICAM1
26keratoconjunctivitis29.7IL5, IL13, RNASE3, CCL11
27bronchiectasis29.7IL8, RNASE3, IGHE, MPO
28churg-strauss syndrome29.7IL5, RNASE3, MPO
29mastocytosis29.7IL5, IL13, IGHE
30giant papillary conjunctivitis29.7IL5, RNASE3, CCL11
31hypertension29.7VCAM1, KNG1, ICAM1
32obesity29.7KNG1, CCL11
33influenza29.7KNG1, CCL11
34atrophic rhinitis11.1
35allergic urticaria10.3
36nasopharyngitis10.3
37neuronitis10.2
38aspergillosis10.2
39adenoiditis10.1
40laryngitis10.1
41pleuropneumonia10.1
42pharyngitis10.1
43mucopolysaccharidosis ih10.1
44psoriasis10.0VCAM1, FCER2, IL8, IL4, IL4R, IL5
45rheumatoid arthritis10.0VCAM1, FCER2, HRH1, IL8, IL4, IL4R
46atopy10.0FCER2, IL4, IL4R, IL5, IL13, RNASE3
47vernal keratoconjunctivitis10.0VCAM1, IL8, IL4, IL5, IL13, RNASE3
48ulcerative colitis10.0IL8, IL4, IL13, RNASE3, EPX, MPO
49inflammatory bowel disease10.0VCAM1, IL8, IL4, IL13, EPX, MPO
50bronchiolitis10.0FCER2, IL8, IL4R, IL5, IL13, RNASE3

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Clinical Features for Rhinitis

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Drugs & Therapeutics for Rhinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rhinitis:

32
Testes, Eye, T cells, Skin, Lung, Bone, B cells, Endothelial, Colon, Tonsil, Heart, Thyroid, Liver, Monocytes, Thymus, Bone marrow, Spleen, Lymph node, Nk cells

Animal Models for Rhinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1ADH5, VIP, CCL11, ICAM1, MPO, IGHE
2MP:000537611.9NGF, IGHE, KNG1, MPO, ICAM1, VIP
3MP:000539711.8CCL11, ICAM1, MPO, IGHE, EPX, IL13
4MP:001076811.6ICAM1, FOXJ1, MPO, NGF, IL13, IL4R
5MP:000538110.9ICAM1, FOXJ1, IL13, IL5, IL4R, IL4
6MP:000538810.8VIP, CCL11, FOXJ1, IL4R

Publications for Rhinitis

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50PubMed
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Articles related to Rhinitis:

(show top 50)    (show all 2032)
idTitleAuthorsYear
1
MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis. (24408538)
2014
2
Treatment of Allergic Rhinitis with Probiotics: An Alternative Approach. (24083221)
2013
3
The effects of mometasone furoate and desloratadine in obstructive sleep apnea syndrome patients with allergic rhinitis. (23883803)
2013
4
Asthma and allergic rhinitis. (23763103)
2013
5
Prevalence and classification of rhinitis in preschool children in Portugal: a nationwide study. (24053488)
2013
6
A hospital-based survey on the prevalence of bronchial asthma in patients with allergic rhinitis in southern China. (24274226)
2013
7
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
8
Efficacy of prophylactic treatment with montelukast and montelukast plus add-on loratadine for seasonal allergic rhinitis. (22525385)
2012
9
Impact of asthma and comorbid allergic rhinitis on quality of life and control in patients of Italian general practitioners. (22957769)
2012
10
Complete right lung agenesis presenting with bronchial asthma and allergic rhinitis. (23001088)
2012
11
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. (22289536)
2011
12
Study on the relationship between SNP of CD14 gene and allergic rhinitis in Xinjiang Uygurs and Hans]. (22384567)
2011
13
Correlation between FOXP3 gene polymorphisms and allergic rhinitis]. (20654176)
2010
14
The expression and significance of interleukin-17 and the infiltrating eosinophils in nasal polyps and nasal mucous of allergic rhinitis]. (20306850)
2010
15
Quality of life in patients with chronic rhinitis after radiofrequency inferior turbinate reduction. (20718172)
2010
16
Consensus Review and Definition of Nonallergic Rhinitis With a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy Part 1. Introduction. (24229340)
2009
17
Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis. (19690661)
2009
18
Does pregnancy-associated plasma protein A have a role in allergic rhinitis? (18588751)
2008
19
A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. (18946234)
2008
20
The urokinase system in patients with intermittent and persistent allergic rhinitis. (18832910)
2008
21
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. (18778489)
2008
22
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
23
Allergen immunotherapy in intermittent allergic rhinitis reduces the intracellular expression of IL-4 by CD8+ T cells. (18054415)
2007
24
Evaluation of a novel immunotherapy for treatment of chronic rhinitis in cats. (16857403)
2006
25
Altered levels of the soluble IL-1, IL-4 and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis. (15178892)
2004
26
Prevalence and differential diagnosis of chronic rhinitis. (11892037)
2001
27
Aspirin-induced rhinitis and asthma. (11964666)
2001
28
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
29
Chronic rhinitis: a manifestation of chronic lymphocytic leukemia. (10512144)
1999
30
Inflammatory mediators in naturally occurring rhinitis. (9515596)
1998
31
Distribution and quantity of neuroendocrine markers in allergic rhinitis. (9655216)
1998
32
Kinetics of eosinophil cationic protein release in mite-allergic rhinitis after specific nasal provocation. (9631691)
1998
33
A comparison of cytokine release from epithelial cells cultured from nasal biopsy specimens of atopic patients with and without rhinitis and nonatopic subjects without rhinitis. (9003213)
1997
34
A case of toxoplasmatic rhinitis and laryngitis. (8758322)
1996
35
Mast cells, eosinophils and IgE-positive cells in the nasal mucosa of patients with vasomotor rhinitis. An immunohistochemical study. (7537565)
1995
36
The role of H2 antagonists in perennial allergic rhinitis. (8361304)
1993
37
The value of electrocautery to the inferior turbinates in the treatment of chronic rhinitis. (2763365)
1989
38
Epizootiological studies on porcine atrophic rhinitis. VII. Study of the aetiology and the local immune response. (2933903)
1985
39
Porcine atrophic rhinitis: a model for studying nasal physiology and pathophysiology. (635368)
1978
40
Atrophic rhinitis in swine fattener herds. A field study of the spread of the disease with infected pigs bought at market. (600693)
1977
41
An antihistamine-sympathomimetic amine combination in vasomotor rhinitis. (4147011)
1973
42
Cryosurgery in chronic rhinitis. (5452511)
1970
43
Studies on the atrophic rhinitis of swine. (5501615)
1970
44
Laryngotracheitis virus in chickens. A model for study of acute nonfatal desquamating rhinitis. (4289294)
1967
45
Interrelation of asthma and vasomotor rhinitis, occurring in patients with housedust atopy. III. In respect to the localization of the symptoms. (13926727)
1962
46
Satisfactory management of vasomotor rhinitis. (13233144)
1955
47
Vasomotor rhinitis and bronchial asthma due to Locust Bean Gum dust. (13148984)
1954
48
Chronic vasomotor rhinitis in pregnancy. (20291340)
1947
49
The syndrome of physical or intrinsic allergy of the head; vasomotor rhinitis and the vasodilating pain syndrome, their relationship to myalgia and endolymphatic hydrops (MAcniA"re's disease) and the reasons for including all four as the syndrome of physical allergy of the head. (21012897)
1946
50
AN OPERATION FOR ATROPHIC RHINITIS (OZAENA): (Preliminary Note.). (20771185)
1923

Genetic Variations for Rhinitis

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Expression for genes affiliated with Rhinitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhinitis

Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

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Sources:
53Reactome, 29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Rhinitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4VIP, CCL11, ICAM1, KNG1, NGF, IL8
2
Hide members
11.3IL4, CCL11, ICAM1, EPX, RNASE3, IL13
3
Hide members
11.3CCL11, ICAM1, IGHE, IL13, IL5, IL4R
4
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
5
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
6
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
711.1CCL11, IGHE, IL5, IL4R, IL4, FCER2
811.0ICAM1, IL13, IL5, IL4, IL8
9
Hide members
10.9CCL11, IL13, IL5, IL4R
1010.9IL13, IL5, IL4R, IL4
1110.9IL13, IL5, IL4R, IL4
12
Hide members
10.9IL4, IL4R, IL5, IL13
1310.9IL5, IL4R, IL4, FCER2
1410.9IL8, IL4, IL5, IL13
1510.9CCL11, IL5, IL4, IL8
1610.8IL4, IL5, IL13
1710.8IL5, IL4R, IL4
1810.8CCL11, IL4, IL8
1910.8VCAM1, IL4, IL4R
20
Hide members
10.8IL5, IL4, IL8
2110.8ICAM1, MPO, KNG1
22
Hide members
10.8VCAM1, FCER2, ICAM1
2310.8ICAM1, IL8, VCAM1
2410.8VCAM1, IL8, ICAM1
2510.8VCAM1, IL8, ICAM1
2610.8VCAM1, MPO, ICAM1

Compounds for genes affiliated with Rhinitis

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44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.6VIP, CCL11, ICAM1, VCAM1, MPO, FCER2
2nitric oxide44 11 2414.2EPX, VIP, HRH1, CCL11, ADH5, ICAM1
3methacholine44 1113.0VIP, CCL11, ICAM1, MPO, KNG1, IGHE
4budesonide44 49 1114.0CCL11, ICAM1, MPO, IGHE, EPX, RNASE3
5allergens4411.9IGHE, EPX, RNASE3, IL13, IL5, IL4R
6fmlp4411.9CCL11, ICAM1, MPO, EPX, RNASE3, IL13
7salbutamol44 49 28 11 2415.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
8dexamethasone44 49 28 1114.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
9leukotriene b444 59 2413.8CCL11, MPO, KNG1, EPX, RNASE3, IL13
10fluticasone propionate44 49 59 1114.8MPO, IGHE, RNASE3, IL13, IL5, IL4
11prednisolone44 28 1113.8IL13, IL5, RNASE3, EPX, NGF, VIP
12cetirizine44 28 11 2414.8HRH1, CCL11, ICAM1, KNG1, IGHE, EPX
13lactate4411.8VCAM1, FCER2, IL8, RNASE3, ICAM1, IL13
14tyrosine4411.8IL5, EPX, RNASE3, IL13, VCAM1, IL4R
15adenylate4411.7RNASE3, VIP, IGHE, NGF, IL13, IL5
16vegf4411.7VCAM1, RNASE3, NGF, MPO, CCL11, VIP
17nedocromil sodium4411.7FCER2, HRH1, ICAM1, IGHE, RNASE3, IL5
18sb 20358044 5912.7ICAM1, IL4, IL8, FCER2, VCAM1, IL13
19sodium cromoglycate4411.7IGHE, RNASE3, IL5, HRH1, VCAM1, ICAM1
20tarc4411.7CCL11, ICAM1, IGHE, IL13, IL5, IL4R
21cyclosporin a44 28 5913.7CCL11, NGF, ICAM1, IGHE, RNASE3, IL4R
22retinoic acid44 2412.6CCL11, ICAM1, IGHE, MPO, NGF, RNASE3
23actinomycin d4411.6NGF, KNG1, ICAM1, CCL11, IGHE, IL8
24herbimycin a44 5912.6IL8, CCL11, NGF, IL5, IL4, FCER2
25ketotifen44 1112.6CCL11, ICAM1, IGHE, EPX, RNASE3, IL5
26salmeterol44 49 28 1114.6IL13, IL5, IL4, IL8, RNASE3, EPX
27montelukast44 49 28 1114.6CCL11, IGHE, RNASE3, IL13, IL5, IL4
28heparin44 28 11 2414.6VCAM1, IL8, MPO, KNG1, EPX, RNASE3
29capsaicin44 2812.5VIP, KNG1, IGHE, NGF, RNASE3, IL5
30rantes4411.5HRH1, IL4, IL4R, CCL11, ICAM1, RNASE3
31desloratadine44 1112.5HRH1, IL8, IL13, ICAM1, IL4, IGHE
32loratadine44 11 2413.4RNASE3, HRH1, IL8, VCAM1, IGHE, ICAM1
33azelastine44 1112.4IL5, ICAM1, IL4, HRH1, RNASE3, IGHE
34ltd44411.4RNASE3, IL13, VIP, KNG1, IL5, HRH1
35n acetylcysteine4411.4CCL11, ICAM1, MPO, IL4, IGHE, IL8
36ltc44411.4CCL11, RNASE3, IL13, IL5, EPX, VIP
37indomethacin44 59 28 1114.4IL5, HRH1, NGF, VIP, KNG1
38pgd24411.3CCL11, IL5, IL13, RNASE3, EPX, IGHE
39anti-histamine4411.3HRH1, CCL11, ICAM1, RNASE3, IGHE
40thymidine44 2412.3NGF, FCER2, HRH1, IL4R, IL5, IL13
41n-formylmethionyl-leucylphenylalanine4411.3ICAM1, CCL11, MPO, IL8, IL5, RNASE3
42pentoxifylline44 1112.2IL13, ICAM1, MPO, IL4, VCAM1, IL8
43praziquantel44 1112.2IL4, RNASE3, IL13, IL5, IGHE
44isoproterenol44 1112.2KNG1, IL5, VCAM1, HRH1
45erythromycin44 49 2 1114.1HRH1, VIP, VCAM1
46pge24411.1EPX, CCL11
47levocetirizine4411.1CCL11, HRH1, IL8, IL4
48rolipram44 59 2813.0KNG1, EPX
49omalizumab44 1111.9IGHE, IL4, IL5, IL13
50unicap4410.6IL5, IGHE, RNASE3, CCL11

GO Terms for genes affiliated with Rhinitis

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16Gene Ontology
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Cellular components related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5VCAM1, CCL11, ICAM1, MPO, KNG1, NGF
2extracellular regionGO:00557611.2IGHE, KNG1, CCL11, VIP, NGF, RNASE3
3external side of plasma membraneGO:00989711.0IL13, IL4, FCER2, VCAM1, ICAM1

Biological processes related to Rhinitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4HRH1, CCL11, KNG1, NGF, IL13, IL5
2immune responseGO:00695511.4CCL11, IGHE, IL13, IL5, IL4R, IL4
3positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
4membrane to membrane dockingGO:02261410.9ICAM1, VCAM1
5regulation of proton transportGO:01015510.8IL13, IL4
6chronic inflammatory responseGO:00254410.8VCAM1, CCL11
7positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.8NGF, IL5, IL4
8regulation of immune responseGO:05077610.8VCAM1, IL4, ICAM1
9eosinophil chemotaxisGO:04824510.7HRH1, CCL11
10response to ethanolGO:04547110.7IL4, IL13, ICAM1
11positive regulation of macrophage activationGO:04303210.4IL4R, IL13

Molecular functions related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.8VCAM1, FCER2, ICAM1

Products for genes affiliated with Rhinitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet