MCID: RHN004
MIFTS: 58

Rhinitis malady

Summaries for Rhinitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards: Rhinitis, also known as rhinitis, nos, is related to allergic rhinitis and asthma. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are Signaling by GPCR and Allograft rejection. The drugs ephedrine and ephedrine hydrochloride and the compounds histamine and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:64 Rhinitis /raɪˈnaɪtɪs/ is a medical term for irritation and inflammation of the mucous membrane... more...

Aliases & Classifications for Rhinitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

rhinitis 8 10 45 61
rhinitis, nos 8


External Ids:

Disease Ontology8 DOID:4483
NCIt40 C34986
SNOMED-CT57 70076002
MeSH35 D012220

Related Diseases for Rhinitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rhinitis family:

chronic rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1allergic rhinitis32.1FCER2, HRH1, IL8, IL4, IL4R, IL5
2asthma31.5IL13, CCL11
3vasomotor rhinitis31.5RNASE3, VIP
4chronic rhinitis31.5HRH1, RNASE3
5allergic asthma31.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
6atopy30.9FCER2, IL4, IL4R, IL5, IL13, RNASE3
7sinusitis30.8IL5, RNASE3, IGHE, CCL11
8allergic conjunctivitis30.6HRH1, IL4, IL5, IL13, RNASE3, IGHE
9urticaria30.6FCER2, HRH1, RNASE3, IGHE, KNG1
10common cold30.4IL8, RNASE3, ICAM1, CCL11
11atopic dermatitis30.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
12allergic bronchopulmonary aspergillosis30.1IL4, IL5, IGHE
13intrinsic asthma30.0FCER2, IL4, IL5, RNASE3, IGHE
14cystic fibrosis30.0IL8, RNASE3, MPO, VIP
15mastocytosis30.0IL5, IL13, IGHE
16tuberculosis30.0IL4, IL4R, EPX
17chronic fatigue syndrome30.0VIP
18wegener's granulomatosis30.0MPO
19vernal keratoconjunctivitis29.8VCAM1, IL8, IL4, IL5, IL13, RNASE3
20graves' disease29.8VCAM1, IL4, IL4R, IL13, MPO, ICAM1
21pulmonary disease, chronic obstructive29.7IL8, IL13, RNASE3, MPO, CCL11
22bronchiectasis29.7IL8, RNASE3, IGHE, MPO
23churg-strauss syndrome29.7IL5, RNASE3, MPO
24giant papillary conjunctivitis29.7IL5, RNASE3, CCL11
25atrophic rhinitis11.1
26allergic urticaria10.3
27n syndrome10.3
28aspergillosis10.2
29ectodermal dysplasia10.2
30klebsiella10.1
31pleuropneumonia10.1
32autonomic dysfunction10.1
33mucopolysaccharidosis ih10.1
34asthma 210.1
35asthma 110.1
36psoriasis10.0VCAM1, FCER2, IL8, IL4, IL4R, IL5
37eosinophilia10.0VCAM1, FCER2, IL8, IL4, IL5, IL13
38rheumatoid arthritis10.0VCAM1, FCER2, HRH1, IL8, IL4, IL4R
39skin disease10.0FCER2, HRH1, IL8, IL4, IL5, IL13
40leukemia10.0FCER2, HRH1, IL4, IL4R, RNASE3, EPX
41pneumonia10.0HRH1, IL8, IL5, IL13, EPX, KNG1
42ulcerative colitis10.0IL8, IL4, IL13, RNASE3, EPX, MPO
43inflammatory bowel disease10.0VCAM1, IL8, IL4, IL13, EPX, MPO
44bronchiolitis10.0FCER2, IL8, IL4R, IL5, IL13, RNASE3
45arthritis10.0FCER2, IL8, IL4, IL13, KNG1, MPO
46pulmonary eosinophilia10.0IL8, IL4, IL5, IL13, RNASE3, EPX
47multiple sclerosis10.0VCAM1, IL4, IL4R, IL5, IL13, NGF
48hypersensitivity reaction type ii disease10.0VCAM1, IL4, IL4R, IL5, IL13, ICAM1
49melanoma10.0VCAM1, HRH1, IL8, IL4, IL4R, KNG1
50dermatitis10.0VCAM1, IL4, IL5, IL13, IGHE, ICAM1

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Clinical Features for Rhinitis

Drugs & Therapeutics for Rhinitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Rhinitis

Anatomical Context for Rhinitis

Animal Models for Rhinitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Rhinitis

Sources:
51PubMed
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Articles related to Rhinitis:

(show top 50)    (show all 2033)
idTitleAuthorsYear
1
Inconclusive evidence for allergic rhinitis to predict a prolonged or chronic course of acute rhinosinusitis. (24233061)
2014
2
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
3
A cross sectional assessment of allergic rhinitis and asthma control at an Immunoallergology outpatient hospital setting using CARAT10 questionnaire. (23643637)
2013
4
Development and validation of a 5-day-ahead hay fever forecast for patients with grass-pollen-induced allergic rhinitis. (23780494)
2013
5
Ocular safety of fluticasone furoate nasal spray in patients with perennial allergic rhinitis: a 2-year study. (23806459)
2013
6
Multiple grass mixes as opposed to single grasses for allergen immunotherapy in allergic rhinitis. (24152153)
2013
7
Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach. (23573194)
2013
8
The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. (22656186)
2012
9
Allergic rhinitis and vascular endothelial growth factor. (22791116)
2012
10
Prevalence and clinical relevance of local allergic rhinitis. (22913574)
2012
11
Suppression of connexin 26 is related to protease-activated receptor 2-mediated pathway in patients with allergic rhinitis. (22391066)
2012
12
Inflammatory markers in exhaled breath condensate in patients with asthma and rhinitis. (23289461)
2012
13
Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects. (22973903)
2012
14
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis. (21352639)
2011
15
Vasomotor rhinitis. (20425499)
2010
16
The expression of IL-23 in nasal mucosa of allergic rhinitis patients and its significance]. (20873540)
2010
17
Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis. (20422678)
2010
18
Expression of CD23 and CD19 on peripheral blood lymphocytes and its association with serum total IgE in patients with allergic rhinitis]. (20359104)
2009
19
Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis. (18607915)
2009
20
Vascular endothelial growth factor produced in nasal glands of perennial allergic rhinitis. (18702899)
2008
21
Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. (17651373)
2008
22
The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis. (16530440)
2007
23
ACE gene polymorphism might disclose why some Taiwanese children with allergic rhinitis develop asthma symptoms but others do not. (17014625)
2006
24
Survey of the therapeutic reactions of CLONGAMMA in allergic rhinitis]. (15934285)
2005
25
A review of montelukast in the treatment of asthma and allergic rhinitis. (15013935)
2004
26
Safety and tolerability of treatments for allergic rhinitis in children. (15366976)
2004
27
Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation. (15281472)
2004
28
Specific immunotherapy effect on interleukin-18 and CD30 serum levels in monosensitized patients with rhinitis. (12866321)
2003
29
Allergic rhinitis--a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. (11840197)
2001
30
The role of thymidine phosphorylase in the pathogenesis of allergic rhinitis. (11039877)
2000
31
Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. (10543283)
1999
32
Comparison of nasal mucosal responsiveness to neuronal stimulation in non-allergic and allergic rhinitis: effects of capsaicin nasal challenge. (9537786)
1998
33
Effect of slow-release theophylline on nasal antigen challenge in subjects with allergic rhinitis. (9648963)
1998
34
Blood levels of eosinophil cationic protein in patients with allergic rhinitis. Evolution after treatment with corticoids]. (9072139)
1997
35
Specific IgE in the identification of allergens in allergic rhinitis Malaysian patients. (7488340)
1995
36
Heterogeneous eosinophils of allergic rhinitis in chemotactic response. (8155995)
1994
37
Experimental atrophic rhinitis in 2 and 4 month old pigs infected sequentially with Bordetella bronchiseptica and toxigenic type D Pasteurella multocida. (1385667)
1992
38
Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. (1742652)
1991
39
Results obtained with Loderix tablet in chronic rhinitis patients. (2576575)
1989
40
Chronic rhinitis in adults. (3286737)
1988
41
Epizootiological studies on porcine atrophic rhinitis. X. Study of the heat-labile exotoxin (HLT) of Pasteurella multocida in mice. (2953198)
1986
42
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
43
Familial atrophic rhinitis: a scanning electron microscopic study. (7430819)
1980
44
Vasomotor rhinitis and nasal dyspnea. (862543)
1977
45
Data on the aetiology of swine atrophic rhinitis. V. The role of genetic factors. (1020729)
1976
46
Generalized bone and joint changes in three pigs with severe atrophic rhinitis. (4531170)
1972
47
Studies of Ca and P metabolism in atrophic rhinitis of swine. I. Studies on the predisposing role of Ca depletion. (4669284)
1972
48
A placebo-controlled trial of imipramine in nonspecific vasomotor rhinitis. (4561390)
1972
49
Some rhinological syndromes and vasomotor rhinitis. (13311963)
1955
50
Polycythaemia rubra with Chronic Rhinitis. (19977883)
1914

Genetic Variations for Rhinitis

Expression for genes affiliated with Rhinitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rhinitis

Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

Sources:
54Reactome, 30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Rhinitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4VIP, CCL11, ICAM1, KNG1, NGF, IL8
2
Hide members
11.3IL4, CCL11, ICAM1, EPX, RNASE3, IL13
3
Hide members
11.3CCL11, ICAM1, IGHE, IL13, IL5, IL4R
4
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
5
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
6
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
711.1CCL11, IGHE, IL5, IL4R, IL4, FCER2
811.0ICAM1, IL13, IL5, IL4, IL8
9
Hide members
10.9CCL11, IL13, IL5, IL4R
1010.9IL13, IL5, IL4R, IL4
1110.9IL13, IL5, IL4R, IL4
12
Hide members
10.9IL4, IL4R, IL5, IL13
1310.9IL5, IL4R, IL4, FCER2
1410.9IL8, IL4, IL5, IL13
1510.9CCL11, IL5, IL4, IL8
1610.8IL4, IL5, IL13
1710.8IL5, IL4R, IL4
1810.8CCL11, IL4, IL8
1910.8VCAM1, IL4, IL4R
20
Hide members
10.8IL5, IL4, IL8
2110.8ICAM1, MPO, KNG1
22
Hide members
10.8VCAM1, FCER2, ICAM1
2310.8ICAM1, IL8, VCAM1
2410.8VCAM1, IL8, ICAM1
2510.8VCAM1, IL8, ICAM1
2610.8VCAM1, MPO, ICAM1

Compounds for genes affiliated with Rhinitis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2414.6VIP, CCL11, ICAM1, VCAM1, MPO, FCER2
2nitric oxide45 11 2414.2EPX, VIP, HRH1, CCL11, ADH5, ICAM1
3methacholine45 1113.0VIP, CCL11, ICAM1, MPO, KNG1, IGHE
4budesonide45 50 1114.0CCL11, ICAM1, MPO, IGHE, EPX, RNASE3
5allergens4511.9IGHE, EPX, RNASE3, IL13, IL5, IL4R
6fmlp4511.9CCL11, ICAM1, MPO, EPX, RNASE3, IL13
7salbutamol45 50 29 11 2415.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
8dexamethasone45 50 29 1114.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
9leukotriene b445 60 2413.8CCL11, MPO, KNG1, EPX, RNASE3, IL13
10fluticasone propionate45 50 60 1114.8MPO, IGHE, RNASE3, IL13, IL5, IL4
11prednisolone45 29 1113.8IL13, IL5, RNASE3, EPX, NGF, VIP
12cetirizine45 29 11 2414.8HRH1, CCL11, ICAM1, KNG1, IGHE, EPX
13lactate4511.8VCAM1, FCER2, IL8, RNASE3, ICAM1, IL13
14tyrosine4511.8IL5, EPX, RNASE3, IL13, VCAM1, IL4R
15adenylate4511.7RNASE3, VIP, IGHE, NGF, IL13, IL5
16vegf4511.7VCAM1, RNASE3, NGF, MPO, CCL11, VIP
17nedocromil sodium4511.7FCER2, HRH1, ICAM1, IGHE, RNASE3, IL5
18sb 20358045 6012.7ICAM1, IL4, IL8, FCER2, VCAM1, IL13
19sodium cromoglycate4511.7IGHE, RNASE3, IL5, HRH1, VCAM1, ICAM1
20tarc4511.7CCL11, ICAM1, IGHE, IL13, IL5, IL4R
21cyclosporin a45 29 6013.7CCL11, NGF, ICAM1, IGHE, RNASE3, IL4R
22retinoic acid45 2412.6CCL11, ICAM1, IGHE, MPO, NGF, RNASE3
23actinomycin d4511.6NGF, KNG1, ICAM1, CCL11, IGHE, IL8
24herbimycin a45 6012.6IL8, CCL11, NGF, IL5, IL4, FCER2
25ketotifen45 1112.6CCL11, ICAM1, IGHE, EPX, RNASE3, IL5
26salmeterol45 50 29 1114.6IL13, IL5, IL4, IL8, RNASE3, EPX
27montelukast45 50 29 1114.6CCL11, IGHE, RNASE3, IL13, IL5, IL4
28heparin45 29 11 2414.6VCAM1, IL8, MPO, KNG1, EPX, RNASE3
29capsaicin45 2912.5VIP, KNG1, IGHE, NGF, RNASE3, IL5
30rantes4511.5HRH1, IL4, IL4R, CCL11, ICAM1, RNASE3
31desloratadine45 1112.5HRH1, IL8, IL13, ICAM1, IL4, IGHE
32loratadine45 11 2413.4RNASE3, HRH1, IL8, VCAM1, IGHE, ICAM1
33azelastine45 1112.4IL5, ICAM1, IL4, HRH1, RNASE3, IGHE
34ltd44511.4RNASE3, IL13, VIP, KNG1, IL5, HRH1
35n acetylcysteine4511.4CCL11, ICAM1, MPO, IL4, IGHE, IL8
36ltc44511.4CCL11, RNASE3, IL13, IL5, EPX, VIP
37indomethacin45 60 29 1114.4IL5, HRH1, NGF, VIP, KNG1
38pgd24511.3CCL11, IL5, IL13, RNASE3, EPX, IGHE
39anti-histamine4511.3HRH1, CCL11, ICAM1, RNASE3, IGHE
40thymidine45 2412.3NGF, FCER2, HRH1, IL4R, IL5, IL13
41n-formylmethionyl-leucylphenylalanine4511.3ICAM1, CCL11, MPO, IL8, IL5, RNASE3
42pentoxifylline45 1112.2IL13, ICAM1, MPO, IL4, VCAM1, IL8
43praziquantel45 1112.2IL4, RNASE3, IL13, IL5, IGHE
44isoproterenol45 1112.2KNG1, IL5, VCAM1, HRH1
45erythromycin45 50 2 1114.1HRH1, VIP, VCAM1
46pge24511.1EPX, CCL11
47levocetirizine4511.1CCL11, HRH1, IL8, IL4
48rolipram45 60 2913.0KNG1, EPX
49omalizumab45 1111.9IGHE, IL4, IL5, IL13
50unicap4510.6IL5, IGHE, RNASE3, CCL11

GO Terms for genes affiliated with Rhinitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5VCAM1, CCL11, ICAM1, MPO, KNG1, NGF
2extracellular regionGO:00557611.2IGHE, KNG1, CCL11, VIP, NGF, RNASE3
3external side of plasma membraneGO:00989711.0IL13, IL4, FCER2, VCAM1, ICAM1

Biological processes related to Rhinitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4HRH1, CCL11, KNG1, NGF, IL13, IL5
2immune responseGO:00695511.4CCL11, IGHE, IL13, IL5, IL4R, IL4
3positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
4membrane to membrane dockingGO:02261410.9ICAM1, VCAM1
5regulation of proton transportGO:01015510.8IL13, IL4
6chronic inflammatory responseGO:00254410.8VCAM1, CCL11
7positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.8NGF, IL5, IL4
8regulation of immune responseGO:05077610.8VCAM1, IL4, ICAM1
9eosinophil chemotaxisGO:04824510.7HRH1, CCL11
10response to ethanolGO:04547110.7IL4, IL13, ICAM1
11positive regulation of macrophage activationGO:04303210.4IL4R, IL13

Molecular functions related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.8VCAM1, FCER2, ICAM1

Products for genes affiliated with Rhinitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rhinitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet