MCID: RHN004
MIFTS: 65

Rhinitis malady

Summaries for Rhinitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. the inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards: Rhinitis, also known as rhinitis, nos, is related to allergic rhinitis and asthma. An important gene associated with Rhinitis is IL13 (interleukin 13), and among its related pathways are Signaling by GPCR and Allograft rejection. The drugs ephedrine and ephedrine hydrochloride and the compounds histamine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and t cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

Wikipedia:63 Rhinitis /raɪˈnaɪtɪs/ or coryza is irritation and inflammation of the mucous membrane inside the... more...

Aliases & Classifications for Rhinitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

rhinitis 8 10 44 60
rhinitis, nos 8


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Disease Ontology8 DOID:4483
NCIt39 C34986
SNOMED-CT56 70076002
MeSH34 D012220

Related Diseases for Rhinitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1allergic rhinitis32.0FCER2, HRH1, IL8, IL4, IL4R, IL5
2asthma31.5IL13, CCL11
3vasomotor rhinitis31.5RNASE3, VIP
4chronic rhinitis31.4HRH1, RNASE3
5allergic asthma31.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
6pneumonia30.7HRH1, IL8, IL5, IL13, EPX, KNG1
7eosinophilia30.7VCAM1, FCER2, IL8, IL4, IL5, IL13
8conjunctivitis30.6HRH1, RNASE3, IGHE
9allergic conjunctivitis30.6HRH1, IL4, IL5, IL13, RNASE3, IGHE
10urticaria30.5FCER2, HRH1, RNASE3, IGHE, KNG1
11dermatitis30.4VCAM1, IL4, IL5, IL13, IGHE, ICAM1
12common cold30.4IL8, RNASE3, ICAM1, CCL11
13atopic dermatitis30.4VCAM1, FCER2, HRH1, IL8, IL4, IL4R
14otitis media30.3RNASE3, IGHE, CCL11
15allergic bronchopulmonary aspergillosis30.1IL4, IL5, IGHE
16migraine30.1VIP
17leukemia29.9FCER2, HRH1, IL4, IL4R, RNASE3, EPX
18food allergy29.9IL4, IL5, IL13, RNASE3, EPX, IGHE
19intrinsic asthma29.9FCER2, IL4, IL5, RNASE3, IGHE
20cystic fibrosis29.9IL8, RNASE3, MPO, VIP
21tuberculosis29.9IL4, IL4R, EPX
22chronic fatigue syndrome29.9VIP
23wegener's granulomatosis29.9MPO
24skin disease29.7FCER2, HRH1, IL8, IL4, IL5, IL13
25graves' disease29.7VCAM1, IL4, IL4R, IL13, MPO, ICAM1
26keratoconjunctivitis29.7IL5, IL13, RNASE3, CCL11
27bronchiectasis29.7IL8, RNASE3, IGHE, MPO
28churg-strauss syndrome29.7IL5, RNASE3, MPO
29mastocytosis29.7IL5, IL13, IGHE
30giant papillary conjunctivitis29.7IL5, RNASE3, CCL11
31hypertension29.7VCAM1, KNG1, ICAM1
32obesity29.7KNG1, CCL11
33influenza29.7KNG1, CCL11
34atrophic rhinitis11.1
35allergic urticaria10.3
36nasopharyngitis10.3
37neuronitis10.2
38aspergillosis10.2
39adenoiditis10.1
40laryngitis10.1
41pleuropneumonia10.1
42pharyngitis10.1
43mucopolysaccharidosis ih10.1
44psoriasis10.0VCAM1, FCER2, IL8, IL4, IL4R, IL5
45rheumatoid arthritis10.0VCAM1, FCER2, HRH1, IL8, IL4, IL4R
46atopy10.0FCER2, IL4, IL4R, IL5, IL13, RNASE3
47vernal keratoconjunctivitis10.0VCAM1, IL8, IL4, IL5, IL13, RNASE3
48ulcerative colitis10.0IL8, IL4, IL13, RNASE3, EPX, MPO
49inflammatory bowel disease10.0VCAM1, IL8, IL4, IL13, EPX, MPO
50bronchiolitis10.0FCER2, IL8, IL4R, IL5, IL13, RNASE3

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to rhinitis

Clinical Features for Rhinitis

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Drugs & Therapeutics for Rhinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Rhinitis

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Anatomical Context for Rhinitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rhinitis:

32
Testes, Eye, T cells, Skin, Lung, Bone, B cells, Endothelial, Liver, Tonsil, Heart, Thyroid, Colon, Thymus, Monocytes, Nk cells, Spleen, Lymph node, Bone marrow

Animal Models for Rhinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1ADH5, VIP, CCL11, ICAM1, MPO, IGHE
2MP:000537611.9NGF, IGHE, KNG1, MPO, ICAM1, VIP
3MP:000539711.8CCL11, ICAM1, MPO, IGHE, EPX, IL13
4MP:001076811.6ICAM1, FOXJ1, MPO, NGF, IL13, IL4R
5MP:000538110.9ICAM1, FOXJ1, IL13, IL5, IL4R, IL4
6MP:000538810.8VIP, CCL11, FOXJ1, IL4R

Publications for Rhinitis

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50PubMed
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Articles related to Rhinitis:

(show top 50)    (show all 2032)
idTitleAuthorsYear
1
Do newly built homes affect rhinitis in children? The ISAAC phase III study in Korea. (24428419)
2014
2
IL-17 producing T cells correlate with polysensitization but not with bronchial hyperresponsiveness in patients with allergic rhinitis. (24428928)
2014
3
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
4
Occupational rhinitis, asthma, and contact urticaria caused by hydrolyzed wheat protein in hairdressers. (24267377)
2013
5
Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice. (24053327)
2013
6
Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. (23672524)
2013
7
Association between allergic rhinitis and nasopharyngeal carcinoma: A population-based study. (24272528)
2013
8
Potential role of Alternaria and Cladosporium species in canine lymphoplasmacytic rhinitis. (23496099)
2013
9
Pollinex Quattro: an innovative four injections immunotherapy in allergic rhinitis. (23584250)
2013
10
Tap water nasal irrigation in adults with seasonal allergic rhinitis: a randomized double-blind study. (24091560)
2013
11
Prevalence of allergic sensitization versus allergic rhinitis symptoms in an unselected population. (23018768)
2013
12
Changing the route of immunotherapy administration: an 18-year survey in pediatric patients with allergic rhinitis and asthma. (24169060)
2013
13
Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells. (23527713)
2013
14
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24169063)
2013
15
Impact of sleep as a specific marker of quality of life in allergic rhinitis. (23247762)
2013
16
Twenty-four-hour duration of effect of intranasal corticosteroids for seasonal allergic rhinitis symptoms: clinical evidence and relevance. (22801016)
2012
17
Localization and upregulation of the nasal histamine H1 receptor in perennial allergic rhinitis. (23132961)
2012
18
Clinical efficacy of sublingual immunotherapy in pediatric patients with allergic rhinitis sensitized to house dust mites: comparison to adult patients. (22582789)
2012
19
Prediction of atopy by skin prick tests in patients with asthma and/or persistent rhinitis. (21489681)
2012
20
Efficacy of mometasone furoate nasal spray for nasal symptoms, quality of life, rhinitis-disturbed sleep, and nasal nitric oxide in patients with perennial allergic rhinitis. (22525384)
2012
21
Grass pollen counts, air pollution levels and allergic rhinitis severity. (22487690)
2012
22
Chronic rhinitis: a manifestation of leprosy. (21938685)
2011
23
Relationship between allergic symptoms and RORC2 and IL-17 in patients with allergic rhinitis]. (21426710)
2011
24
Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge. (21255397)
2011
25
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
26
CLC- a novel susceptibility gene for allergic rhinitis? (19650845)
2010
27
Nonallergic rhinitis, with a focus on vasomotor rhinitis: clinical importance, differential diagnosis, and effective treatment recommendations. (23282951)
2009
28
Investigation of olfactory threshold responses in chronic rhinitis subtypes. (18219841)
2007
29
Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis. (16083804)
2005
30
Monitoring the efficacy of immunotherapy by symptom scores and the skin prick test in patients with allergic rhinitis]. (13679688)
2003
31
Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitis. (12532104)
2003
32
Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects. (12020693)
2002
33
Linkage of allergic rhinitis with HLA-DRB alleles polymorphism]. (12541760)
2001
34
Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. (11416876)
2001
35
Allergen induced mRNA expression of interleukin-5, but not of interleukin-4 and interferon-gamma, in peripheral blood mononuclear cells obtained before the pollen season predicts the clinical efficacy of immunotherapy for seasonal allergic rhinitis. (10652165)
2000
36
Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. (10383595)
1999
37
Eosinophil cationic protein (ECP) and tryptase in the nasal lavage fluid (NLF) of children with grass pollen rhinitis: levocabastine effect. (9578915)
1998
38
The exchange and significance of the glucocorticoid receptor of circum-circulative blood lymphocyte of cases with allergic rhinitis]. (11263226)
1998
39
Suppression of seasonal increase in serum interleukin-5 is linked to the clinical efficacy of immunotherapy for seasonal allergic rhinitis. (9879413)
1998
40
200 cases of chronic rhinitis treated by acupuncture at nei ying xiang. (10437247)
1997
41
Cetirizine treatment of rhinitis in children with pollen allergy: evidence of its antiallergic activity. (9383256)
1997
42
Anticholinergic Therapy for Allergic and Nonallergic Rhinitis and the Common Cold, Symposium proceedings. Aspen, Colorado, August 1994. (7751522)
1995
43
Characterization of Pasteurella multocida from nasal cavities of piglets from farms with or without atrophic rhinitis. (1624554)
1992
44
Epizootiological studies on porcine atrophic rhinitis. XV. Results of local immunization with a live Bordetella bronchiseptica strain in a large-scale pig herd affected by atrophic rhinitis. (2978213)
1988
45
Genetic control of immune response to pseudorabies and atrophic rhinitis vaccines: II. Comparison of additive direct and maternal genetic effects. (3558147)
1987
46
Timolol for vasomotor rhinitis. (7278906)
1981
47
Treatment of allergic and vasomotor rhinitis by the local application of silver nitrate. (7430808)
1980
48
Pathology of experimental Bordetella bronchiseptica infection in swine: atrophic rhinitis. (5335278)
1966
49
The use of a combination of two antihistaminic drugs in the treatment of allergic vasomotor rhinitis. (15419583)
1950
50
Cases and Specimens illustrating Work on Atrophic Rhinitis (Ozaena) and Tuberculosis. (19979732)
1917

Genetic Variations for Rhinitis

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Expression for genes affiliated with Rhinitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhinitis

Search GEO for disease gene expression data for Rhinitis.

Pathways for genes affiliated with Rhinitis

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53Reactome, 29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Rhinitis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4VIP, CCL11, ICAM1, KNG1, NGF, IL8
2
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11.3IL4, CCL11, ICAM1, EPX, RNASE3, IL13
3
Hide members
11.3CCL11, ICAM1, IGHE, IL13, IL5, IL4R
4
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11.1CCL11, IL13, IL5, IL4R, IL4, IL8
5
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11.1CCL11, IL13, IL5, IL4R, IL4, IL8
6
Hide members
11.1CCL11, IL13, IL5, IL4R, IL4, IL8
711.1CCL11, IGHE, IL5, IL4R, IL4, FCER2
811.0ICAM1, IL13, IL5, IL4, IL8
9
Hide members
10.9CCL11, IL13, IL5, IL4R
1010.9IL13, IL5, IL4R, IL4
1110.9IL13, IL5, IL4R, IL4
12
Hide members
10.9IL4, IL4R, IL5, IL13
1310.9IL5, IL4R, IL4, FCER2
1410.9IL8, IL4, IL5, IL13
1510.9CCL11, IL5, IL4, IL8
1610.8IL4, IL5, IL13
1710.8IL5, IL4R, IL4
1810.8CCL11, IL4, IL8
1910.8VCAM1, IL4, IL4R
20
Hide members
10.8IL5, IL4, IL8
2110.8ICAM1, MPO, KNG1
22
Hide members
10.8VCAM1, FCER2, ICAM1
2310.8ICAM1, IL8, VCAM1
2410.8VCAM1, IL8, ICAM1
2510.8VCAM1, IL8, ICAM1
2610.8VCAM1, MPO, ICAM1

Compounds for genes affiliated with Rhinitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.6VIP, CCL11, ICAM1, VCAM1, MPO, FCER2
2nitric oxide44 11 2414.2EPX, VIP, HRH1, CCL11, ADH5, ICAM1
3methacholine44 1113.0VIP, CCL11, ICAM1, MPO, KNG1, IGHE
4budesonide44 49 1114.0CCL11, ICAM1, MPO, IGHE, EPX, RNASE3
5allergens4411.9IGHE, EPX, RNASE3, IL13, IL5, IL4R
6fmlp4411.9CCL11, ICAM1, MPO, EPX, RNASE3, IL13
7salbutamol44 49 28 11 2415.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
8dexamethasone44 49 28 1114.9VIP, CCL11, IGHE, EPX, RNASE3, IL13
9leukotriene b444 59 2413.8CCL11, MPO, KNG1, EPX, RNASE3, IL13
10fluticasone propionate44 49 59 1114.8MPO, IGHE, RNASE3, IL13, IL5, IL4
11prednisolone44 28 1113.8IL13, IL5, RNASE3, EPX, NGF, VIP
12cetirizine44 28 11 2414.8HRH1, CCL11, ICAM1, KNG1, IGHE, EPX
13lactate4411.8VCAM1, FCER2, IL8, RNASE3, ICAM1, IL13
14tyrosine4411.8IL5, EPX, RNASE3, IL13, VCAM1, IL4R
15adenylate4411.7RNASE3, VIP, IGHE, NGF, IL13, IL5
16vegf4411.7VCAM1, RNASE3, NGF, MPO, CCL11, VIP
17nedocromil sodium4411.7FCER2, HRH1, ICAM1, IGHE, RNASE3, IL5
18sb 20358044 5912.7ICAM1, IL4, IL8, FCER2, VCAM1, IL13
19sodium cromoglycate4411.7IGHE, RNASE3, IL5, HRH1, VCAM1, ICAM1
20tarc4411.7CCL11, ICAM1, IGHE, IL13, IL5, IL4R
21cyclosporin a44 28 5913.7CCL11, NGF, ICAM1, IGHE, RNASE3, IL4R
22retinoic acid44 2412.6CCL11, ICAM1, IGHE, MPO, NGF, RNASE3
23actinomycin d4411.6NGF, KNG1, ICAM1, CCL11, IGHE, IL8
24herbimycin a44 5912.6IL8, CCL11, NGF, IL5, IL4, FCER2
25ketotifen44 1112.6CCL11, ICAM1, IGHE, EPX, RNASE3, IL5
26salmeterol44 49 28 1114.6IL13, IL5, IL4, IL8, RNASE3, EPX
27montelukast44 49 28 1114.6CCL11, IGHE, RNASE3, IL13, IL5, IL4
28heparin44 28 11 2414.6VCAM1, IL8, MPO, KNG1, EPX, RNASE3
29capsaicin44 2812.5VIP, KNG1, IGHE, NGF, RNASE3, IL5
30rantes4411.5HRH1, IL4, IL4R, CCL11, ICAM1, RNASE3
31desloratadine44 1112.5HRH1, IL8, IL13, ICAM1, IL4, IGHE
32loratadine44 11 2413.4RNASE3, HRH1, IL8, VCAM1, IGHE, ICAM1
33azelastine44 1112.4IL5, ICAM1, IL4, HRH1, RNASE3, IGHE
34ltd44411.4RNASE3, IL13, VIP, KNG1, IL5, HRH1
35n acetylcysteine4411.4CCL11, ICAM1, MPO, IL4, IGHE, IL8
36ltc44411.4CCL11, RNASE3, IL13, IL5, EPX, VIP
37indomethacin44 59 28 1114.4IL5, HRH1, NGF, VIP, KNG1
38pgd24411.3CCL11, IL5, IL13, RNASE3, EPX, IGHE
39anti-histamine4411.3HRH1, CCL11, ICAM1, RNASE3, IGHE
40thymidine44 2412.3NGF, FCER2, HRH1, IL4R, IL5, IL13
41n-formylmethionyl-leucylphenylalanine4411.3ICAM1, CCL11, MPO, IL8, IL5, RNASE3
42pentoxifylline44 1112.2IL13, ICAM1, MPO, IL4, VCAM1, IL8
43praziquantel44 1112.2IL4, RNASE3, IL13, IL5, IGHE
44isoproterenol44 1112.2KNG1, IL5, VCAM1, HRH1
45erythromycin44 49 2 1114.1HRH1, VIP, VCAM1
46pge24411.1EPX, CCL11
47levocetirizine4411.1CCL11, HRH1, IL8, IL4
48rolipram44 59 2813.0KNG1, EPX
49omalizumab44 1111.9IGHE, IL4, IL5, IL13
50unicap4410.6IL5, IGHE, RNASE3, CCL11

GO Terms for genes affiliated with Rhinitis

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16Gene Ontology
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Cellular components related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5VCAM1, CCL11, ICAM1, MPO, KNG1, NGF
2extracellular regionGO:00557611.2IGHE, KNG1, CCL11, VIP, NGF, RNASE3
3external side of plasma membraneGO:00989711.0IL13, IL4, FCER2, VCAM1, ICAM1

Biological processes related to Rhinitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4HRH1, CCL11, KNG1, NGF, IL13, IL5
2immune responseGO:00695511.4CCL11, IGHE, IL13, IL5, IL4R, IL4
3positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
4membrane to membrane dockingGO:02261410.9ICAM1, VCAM1
5regulation of proton transportGO:01015510.8IL13, IL4
6chronic inflammatory responseGO:00254410.8VCAM1, CCL11
7positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.8NGF, IL5, IL4
8regulation of immune responseGO:05077610.8VCAM1, IL4, ICAM1
9eosinophil chemotaxisGO:04824510.7HRH1, CCL11
10response to ethanolGO:04547110.7IL4, IL13, ICAM1
11positive regulation of macrophage activationGO:04303210.4IL4R, IL13

Molecular functions related to Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:00517810.8VCAM1, FCER2, ICAM1

Products for genes affiliated with Rhinitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet