MCID: RHN002
MIFTS: 39

Rhinoscleroma

Categories: Infectious diseases

Aliases & Classifications for Rhinoscleroma

MalaCards integrated aliases for Rhinoscleroma:

Name: Rhinoscleroma 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11336
ICD9CM 34 040.1
MeSH 41 D012226
SNOMED-CT 64 72409005
UMLS 69 C0035468

Summaries for Rhinoscleroma

Disease Ontology : 12 A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

MalaCards based summary : Rhinoscleroma is related to rhinosporidiosis and chronic rhinitis. An important gene associated with Rhinoscleroma is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways are NF-kappaB Signaling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ciprofloxacin and Gemifloxacin have been mentioned in the context of this disorder. Affiliated tissues include trachea, testes and skin, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and hematopoietic system

Wikipedia : 72 Rhinoscleroma, or simply scleroma, is a chronic granulomatous bacterial disease of the nose that can... more...

Related Diseases for Rhinoscleroma

Diseases related to Rhinoscleroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 rhinosporidiosis 28.3 CD68 CD79A DCXR NCAM1 RHNO1 SERPINA1
2 chronic rhinitis 11.3
3 mastoiditis 10.5 RHNO1 SLC29A3
4 frontal sinusitis 10.4 DCXR RHNO1
5 ethmoid sinusitis 10.4 DCXR RHNO1
6 maxillary sinusitis 10.4 CD79A RHNO1
7 polyclonal hypergammaglobulinemia 10.4 CD79A SLC29A3
8 transient hypogammaglobulinemia of infancy 10.4 CD19 CD79A
9 chronic maxillary sinusitis 10.3 CD79A RHNO1
10 congenital hypogammaglobulinemia 10.3 CD19 CD79A
11 conjunctival disease 10.3 CD79A RHNO1
12 gamma heavy chain disease 10.3 CD19 CD79A
13 small intestine lymphoma 10.3 CD19 CD79A
14 middle ear disease 10.3 CD79A SLC29A3
15 paranasal sinus disease 10.3 CD79A RHNO1
16 geniculate herpes zoster 10.3 CD79A SERPINA1
17 cd3zeta deficiency 10.3 CCR2 NCAM1
18 solitary osseous plasmacytoma 10.2 CD19 NCAM1
19 protein-losing enteropathy 10.2 CD79A SERPINA1
20 rectum squamous cell carcinoma 10.2 DCXR TNFRSF1B
21 nasal cavity disease 10.2 CD79A RHNO1
22 byssinosis 10.2 CD79A SERPINA1
23 multiple cranial nerve palsy 10.2 NCAM1 RHNO1
24 mature b-cell neoplasm 10.2 CD19 CD79A
25 nose disease 10.2 CD79A RHNO1
26 cystadenofibroma 10.1 NCAM1 SERPINA1
27 b cell deficiency 10.1 CD19 CD79A
28 acute salpingitis 10.1 CD79A TNFRSF1B
29 panniculitis 10.1 NCAM1 SERPINA1
30 norwegian scabies 10.1 CD79A TNFRSF1B
31 granulomatous hepatitis 10.1 CD79A TNFRSF1B
32 upper respiratory tract disease 10.1 CD79A RHNO1
33 respiratory system disease 10.1 CD79A RHNO1 SERPINA1
34 chronic salpingitis 10.1 CD79A TNFRSF1B
35 cervicitis 10.1
36 cicatricial pemphigoid 10.1 CD79A TNFRSF1B
37 orbital plasma cell granuloma 10.0 NCAM1 TNFRSF1B
38 plasma protein metabolism disease 10.0 CD19 CD79A SERPINA1
39 hypersensitivity reaction type iv disease 10.0 CD79A TNFRSF1B
40 ocular cicatricial pemphigoid 10.0 CD79A TNFRSF1B
41 exanthem 10.0 CD79A TNFRSF1B
42 laryngitis 10.0
43 rosai-dorfman disease 10.0
44 viral esophagitis 10.0 CD68 CD79A
45 cogan syndrome 10.0 CD79A TNFRSF1B
46 lymphoplasmacyte-rich meningioma 10.0 CD68 CD79A
47 blepharochalasis 10.0 CD68 CD79A
48 monoclonal gammopathy of uncertain significance 10.0 CD19 CD79A NCAM1
49 subcorneal pustular dermatosis 10.0 CD79A TNFRSF1B
50 plasma cell neoplasm 10.0 CD19 CD79A NCAM1

Comorbidity relations with Rhinoscleroma via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Rhinoscleroma:



Diseases related to Rhinoscleroma

Symptoms & Phenotypes for Rhinoscleroma

GenomeRNAi Phenotypes related to Rhinoscleroma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 CD68 CD79A NCAM1 SERPINA1

MGI Mouse Phenotypes related to Rhinoscleroma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCR2 CD19 CD68 CD79A SLC29A3 SPN
2 immune system MP:0005387 9.5 CCR2 CD19 CD68 CD79A SLC29A3 SPN
3 neoplasm MP:0002006 9.1 CCR2 CD19 CD79A SLC29A3 SPN TNFRSF1B

Drugs & Therapeutics for Rhinoscleroma

Drugs for Rhinoscleroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Early Phase 1 85721-33-1 2764
2
Gemifloxacin Approved, Investigational Early Phase 1 175463-14-6 9571107 5464436
3
Rifampin Approved Early Phase 1 13292-46-1 5381226 5458213
4 Anti-Bacterial Agents Early Phase 1
5 Antibiotics, Antitubercular Early Phase 1
6 Anti-Infective Agents Early Phase 1
7 Antitubercular Agents Early Phase 1
8 Cytochrome P-450 CYP1A2 Inhibitors Early Phase 1
9 Cytochrome P-450 CYP3A Inducers Early Phase 1
10 Cytochrome P-450 Enzyme Inhibitors Early Phase 1
11 Fluoroquinolones Early Phase 1
12 Nucleic Acid Synthesis Inhibitors Early Phase 1
13 Topoisomerase Inhibitors Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
2 Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma Not yet recruiting NCT03326050 Early Phase 1 Gemifloxacin;Ciprofloxacin;Rifampicin

Search NIH Clinical Center for Rhinoscleroma

Cochrane evidence based reviews: rhinoscleroma

Genetic Tests for Rhinoscleroma

Anatomical Context for Rhinoscleroma

MalaCards organs/tissues related to Rhinoscleroma:

38
Trachea, Testes, Skin, Lymph Node, Monocytes, Bone

Publications for Rhinoscleroma

Articles related to Rhinoscleroma:

(show top 50) (show all 203)
# Title Authors Year
1
Rhinoscleroma pathogenesis: The type K3 capsule of Klebsiella rhinoscleromatis is a virulence factor not involved in Mikulicz cells formation. ( 29381692 )
2018
2
Rhinoscleroma: a chronic infectious disease of poor areas with characteristic histological features - report of a series of six cases. ( 28420289 )
2017
3
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. ( 28239581 )
2017
4
Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae. ( 27293924 )
2016
5
A case of laryngeal rhinoscleroma. ( 26778445 )
2016
6
Tracheal rhinoscleroma. ( 26769262 )
2016
7
Rhinoscleroma with intracranial extension: A rare case. ( 27147167 )
2016
8
Images in Clinical Medicine. Rhinoscleroma. ( 26083225 )
2015
9
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. ( 26163236 )
2015
10
Rhinoscleroma of nose extruding into oral cavity. ( 25933455 )
2015
11
Laryngeal involvement of rhinoscleroma. ( 26340893 )
2015
12
Rhinoscleroma: a detailed histopathological diagnostic insight. ( 26339415 )
2015
13
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. ( 29021044 )
2015
14
Rhinoscleroma in a 5-year-old Portuguese Child. ( 24445824 )
2014
15
Rhinoscleroma: a case series report and review of the literature. ( 23904142 )
2013
16
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes. ( 23554169 )
2013
17
Emperipolesis is not pathognomonic for Rosai-Dorfman disease: rhinoscleroma mimicking Rosai-Dorfman disease, a clinical series. ( 24238175 )
2013
18
Rhinoscleroma presenting as a nasal-palatal mass with airway obstruction. ( 24358881 )
2013
19
Rhinoscleroma in an urban nonendemic setting. ( 22166959 )
2012
20
Rhinoscleroma: a case series. ( 22337196 )
2012
21
Rhinoscleroma with involvement of the maxillary sinus, orbital floor, and temporomandibular joint: a case report. ( 21549476 )
2012
22
Coexistence of rhinoscleroma with Rosai-Dorfman disease: is rhinoscleroma a cause of this disease? ( 22643208 )
2012
23
Rhinoscleroma in an immigrant from Egypt: a case report. ( 23379711 )
2012
24
Rhinoscleroma: an updated experience through the last 10 years. ( 21198342 )
2011
25
PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. ( 21629720 )
2011
26
Retrospective study of the rhinoscleroma about 14 cases in ENT departments of university hospitals (CA'te d'Ivoire). ( 21256101 )
2011
27
Airway management of an unusual case of recurrent rhinoscleroma. ( 21897516 )
2011
28
Pathology quiz case 1. Rhinoscleroma. ( 22006786 )
2011
29
Rhinoscleroma: a retrospective study of pathologic and clinical features. ( 21453653 )
2011
30
Cytohistological features of rhinoscleroma. ( 22234117 )
2011
31
B lymphocyte subsets in patients with rhinoscleroma. ( 21493362 )
2011
32
Rhinoscleroma: case report. ( 20015775 )
2010
33
Rhinoscleroma: a case report. ( 21225500 )
2010
34
Septal rhinoscleroma. ( 21217987 )
2010
35
Rhinoscleroma causing severe bilateral nasal obstruction. ( 20563449 )
2010
36
Tracheobronchial rhinoscleroma. ( 23168595 )
2009
37
Rhinoscleroma of the sinuses. ( 19146007 )
2008
38
Bilateral nasal vestibular stenosis: a case of rhinoscleroma and review of surgical techniques. ( 23120507 )
2008
39
Rhinoscleroma: a French national retrospective study of epidemiological and clinical features. ( 18947330 )
2008
40
Rhinoscleroma in a young adult with chronic rhinitis and dyspnea. ( 18816882 )
2008
41
Test and teach. Number 39. Diagnosis: Rhinoscleroma. ( 17886103 )
2007
42
Radiology quiz case 2. Rhinoscleroma and cervical emphysema. ( 17576916 )
2007
43
Rhinoscleroma: a clinicopathological study from the Gulf region. ( 17304395 )
2007
44
Rhinoscleroma: eight Peruvian cases. ( 17086321 )
2006
45
Modification of lymphocyte subsets in patients with rhinoscleroma. ( 17084224 )
2006
46
Clinical photographic quiz. Nasal polyposis, inverted papilloma, sino-nasal tumour, rhinoscleroma. ( 16649466 )
2006
47
Rhinoscleroma: case report. ( 17143439 )
2006
48
Simultaneous occurrence of nasal and cervical rhinoscleroma. ( 16930003 )
2006
49
Rhinoscleroma of the larynx. ( 16045790 )
2005
50
Rhinoscleroma causing upper airway obstruction. ( 15776127 )
2005

Variations for Rhinoscleroma

Expression for Rhinoscleroma

Search GEO for disease gene expression data for Rhinoscleroma.

Pathways for Rhinoscleroma

GO Terms for Rhinoscleroma

Cellular components related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CCR2 CD19 CD79A SPN TNFRSF1B
2 external side of plasma membrane GO:0009897 8.92 CCR2 CD19 CD79A NCAM1

Biological processes related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.33 CD19 CD79A TNFRSF1B
2 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.96 CCR2 SPN
3 cellular defense response GO:0006968 8.8 CCR2 CD19 SPN

Sources for Rhinoscleroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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