MCID: RHY001
MIFTS: 40

Rhyns Syndrome

Categories: Rare diseases, Eye diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Rhyns Syndrome

MalaCards integrated aliases for Rhyns Syndrome:

Name: Rhyns Syndrome 54 50 56 69
Retinitis Pigmentosa, Hypopituitarism, Nephronophthisis, and Mild Skeletal Dysplasia 50
Retinitis Pigmentosa-Hypopituitarism-Nephronophthisis-Skeletal Dysplasia Syndrome 56
Retinitis Pigmentosa Syndrome 50

Characteristics:

Orphanet epidemiological data:

56
rhyns syndrome
Inheritance: Autosomal recessive; Prevalence: <1/1000000 (Worldwide);

OMIM:

54
Inheritance:
? autosomal recessive


Classifications:



Summaries for Rhyns Syndrome

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 140976disease definitionrhyns syndrome is characterised by the association of retinitis pigmentosa, hypopituitarism, nephronophthisis, and skeletal dysplasia.epidemiologyso far, it has been described in four males.genetic counselingautosomal recessive transmission is likely but an x-linked mode of inheritance cannot be excluded.visit the orphanet disease page for more resources. last updated: 7/15/2008

MalaCards based summary : Rhyns Syndrome, also known as retinitis pigmentosa, hypopituitarism, nephronophthisis, and mild skeletal dysplasia, is related to osteochondrodysplatic nanism-deafness-retinitis pigmentosa syndrome and hypogonadotropic hypogonadism-retinitis pigmentosa syndrome, and has symptoms including ptosis, osteopenia and hypoplastic ilia. An important gene associated with Rhyns Syndrome is RHO (Rhodopsin), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Phototransduction. Affiliated tissues include liver, eye and bone, and related phenotypes are nervous system and cardiovascular system

Description from OMIM: 602152

Related Diseases for Rhyns Syndrome

Diseases related to Rhyns Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
id Related Disease Score Top Affiliating Genes
1 osteochondrodysplatic nanism-deafness-retinitis pigmentosa syndrome 11.8
2 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 11.8
3 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 11.8
4 neuropathy, ataxia, and retinitis pigmentosa 11.1
5 usher syndrome 10.9
6 actin-accumulation myopathy 10.8 PRPH2 RHO
7 collagen vi-related myopathy 10.8 PDE6B RHO
8 double outlet right ventricle with non-committed subpulmonary ventricular septal defect 10.8 PRPH2 ROM1
9 aldred syndrome 10.8
10 ataxia, posterior column, with retinitis pigmentosa 10.8
11 retinitis pigmentosa with or without skeletal anomalies 10.8
12 retinitis pigmentosa, x-linked, and sinorespiratory infections, with or without deafness 10.8
13 chromosome xp11.3 deletion syndrome 10.8
14 macular dystrophy, patterned, 1 10.8 PRPH2 RHO ROM1
15 blessig's cysts 10.7 PRPH2 ROM1 RPGR
16 leber congenital amaurosis 9 10.7 RDH12 RPE65 TULP1
17 acitretin/etretinate embryopathy 10.7 RHO TULP1
18 urofacial syndrome 1 10.7 RDH12 RPGR
19 asthma-related traits 8 10.6 RHO RPGR USH2A
20 otof-related deafness 10.6 CLRN1 USH2A
21 retinitis pigmentosa 19 10.6 CNGA1 PDE6B
22 lumbosacral plexus lesion 10.6 RHO RPE65
23 ichthyosis, congenital, autosomal recessive 2 10.5 PDE6A RPE65
24 combined oxidative phosphorylation deficiency 3 10.5 PDE6B PRPH2 RHO RPE65
25 stargardt disease 1 10.5 RHO ROM1
26 acute biphenotypic leukemia 10.5 CNGB1 RPE65 RPGR
27 macular degeneration, age-related, 1 10.4 PDE6B PRPH2 RHO RPE65
28 posterior polar cataract 10.4 PDE6B RHO RPE65 RPGR
29 ichthyosis with confetti 10.3 PROM1 PRPH2 RPGR
30 trichohepatoenteric syndrome 1 10.3 CLRN1 PDE6A PDE6B USH2A
31 tendinitis 10.3 PROM1 PRPH2 RDH12 RHO RPE65 RPGR
32 angiolipoma 10.2 PRPH2 RHO RP1 RPE65 RPGR SNRNP200
33 whipple disease 10.0 PDE6B PRPH2 RHO ROM1 RPE65 RPGR
34 brugada syndrome 9.9 CLRN1 RPGR USH2A
35 limbal stem cell deficiency 9.8 PDE6B PRPH2 RDH12 RHO RPE65 RPGR
36 retinitis 9.7
37 growth hormone deficiency 9.7
38 skeletal dysplasias 9.7
39 skeletal dysplasia 9.7
40 retinitis pigmentosa 9.7
41 hereditary breast ovarian cancer 9.7 PDE6B PRPH2 RDH12 RHO ROM1 RPE65
42 impetigo 9.2 BBS10 C2orf71 PROM1 PRPH2 RDH12 RHO
43 osteopoikilosis and dacryocystitis 7.2 BBS10 C2orf71 CLRN1 CNGA1 CNGB1 PDE6A
44 scar contracture 7.2 BBS10 C2orf71 CLRN1 CNGA1 CNGB1 PDE6A

Graphical network of the top 20 diseases related to Rhyns Syndrome:



Diseases related to Rhyns Syndrome

Symptoms & Phenotypes for Rhyns Syndrome

Symptoms via clinical synopsis from OMIM:

54

GU:
renal failure
nephronophthisis

Endocrine:
growth hormone deficiency
hypopituitarism
thyroid stimulating hormone deficiency

Skel:
skeletal dysplasia

Eyes:
retinitis pigmentosa
enophthalmos
eyelid ptosis

GI:
liver fibrosis

Ears:
conduction deafness


Clinical features from OMIM:

602152

Human phenotypes related to Rhyns Syndrome:

56 32 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000508
2 osteopenia 56 32 frequent (33%) Frequent (79-30%) HP:0000938
3 hypoplastic ilia 56 32 frequent (33%) Frequent (79-30%) HP:0000946
4 rod-cone dystrophy 56 32 hallmark (90%) Very frequent (99-80%) HP:0000510
5 nephronophthisis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000090
6 delayed skeletal maturation 56 32 frequent (33%) Frequent (79-30%) HP:0002750
7 hypopituitarism 56 32 hallmark (90%) Very frequent (99-80%) HP:0040075
8 skeletal dysplasia 56 32 frequent (33%) Frequent (79-30%) HP:0002652
9 hearing impairment 56 32 frequent (33%) Frequent (79-30%) HP:0000365
10 small epiphyses 56 32 frequent (33%) Frequent (79-30%) HP:0010585
11 cranial nerve vi palsy 56 32 frequent (33%) Frequent (79-30%) HP:0006897
12 deeply set eye 56 32 frequent (33%) Frequent (79-30%) HP:0000490
13 multicystic kidney dysplasia 56 32 frequent (33%) Frequent (79-30%) HP:0000003
14 abnormality of the liver 56 32 hallmark (90%) Very frequent (99-80%) HP:0001392
15 abnormality of body height 56 32 frequent (33%) Frequent (79-30%) HP:0000002
16 abnormality of the acetabulum 56 32 frequent (33%) Frequent (79-30%) HP:0003170
17 renal insufficiency 32 HP:0000083
18 growth hormone deficiency 32 HP:0000824
19 cranial nerve paralysis 56 Frequent (79-30%)
20 abnormality of the skeletal system 56 Very frequent (99-80%)
21 conductive hearing impairment 32 HP:0000405
22 pituitary hypothyroidism 32 HP:0008245
23 abnormality of long bone morphology 56 Frequent (79-30%)

MGI Mouse Phenotypes related to Rhyns Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.03 BBS10 C2orf71 CLRN1 PDE6A PDE6B PROM1
2 cardiovascular system MP:0005385 9.86 RP1 RPGR TULP1 PDE6B PROM1 PRPH2
3 pigmentation MP:0001186 9.56 C2orf71 PDE6B PROM1 PRPH2 RHO RPE65
4 vision/eye MP:0005391 9.5 BBS10 C2orf71 CLRN1 PDE6A PDE6B PROM1

Drugs & Therapeutics for Rhyns Syndrome

Search Clinical Trials , NIH Clinical Center for Rhyns Syndrome

Genetic Tests for Rhyns Syndrome

Anatomical Context for Rhyns Syndrome

MalaCards organs/tissues related to Rhyns Syndrome:

39
Liver, Eye, Bone, Kidney, Thyroid, Pituitary

Publications for Rhyns Syndrome

Articles related to Rhyns Syndrome:

id Title Authors Year
1
Retinitis pigmentosa, growth hormone deficiency, and acromelic skeletal dysplasia in two brothers: possible familial RHYNS syndrome. ( 11391657 )
2001

Variations for Rhyns Syndrome

ClinVar genetic disease variations for Rhyns Syndrome:

6 (show top 50) (show all 105)
id Gene Variation Type Significance SNP ID Assembly Location
1 BBS10 NM_024685.3(BBS10): c.271dupT (p.Cys91Leufs) duplication Pathogenic rs549625604 GRCh38 Chromosome 12, 76347714: 76347714
2 RDH12 NM_152443.2(RDH12): c.377C> T (p.Ala126Val) single nucleotide variant Pathogenic rs202126574 GRCh37 Chromosome 14, 68192801: 68192801
3 USH2A NM_206933.2(USH2A): c.2299delG (p.Glu767Serfs) deletion Pathogenic rs80338903 GRCh37 Chromosome 1, 216420437: 216420437
4 USH2A NM_206933.2(USH2A): c.11864G> A (p.Trp3955Ter) single nucleotide variant Pathogenic rs111033364 GRCh37 Chromosome 1, 215901574: 215901574
5 USH2A NM_206933.2(USH2A): c.14020A> G (p.Arg4674Gly) single nucleotide variant Pathogenic rs80338904 GRCh37 Chromosome 1, 215844427: 215844427
6 CLRN1 NM_001195794.1(CLRN1): c.189C> A (p.Tyr63Ter) single nucleotide variant Pathogenic rs111033267 GRCh37 Chromosome 3, 150690307: 150690307
7 PROM1 NM_006017.2(PROM1): c.1726C> T (p.Gln576Ter) single nucleotide variant Pathogenic rs137853005 GRCh37 Chromosome 4, 15995651: 15995651
8 RP1 NM_006269.1(RP1): c.2285_2289delTAAAT (p.Leu762Tyrfs) deletion Pathogenic rs869320726 GRCh38 Chromosome 8, 54626167: 54626171
9 TULP1 NM_003322.5(TULP1): c.1145T> C (p.Phe382Ser) single nucleotide variant Pathogenic rs121909076 GRCh37 Chromosome 6, 35471593: 35471593
10 PHYH NM_006214.3(PHYH): c.823C> T (p.Arg275Trp) single nucleotide variant Pathogenic/Likely pathogenic rs104894178 GRCh37 Chromosome 10, 13325695: 13325695
11 SNRNP200 NM_014014.4(SNRNP200): c.3260C> T (p.Ser1087Leu) single nucleotide variant Pathogenic/Likely pathogenic rs267607077 GRCh37 Chromosome 2, 96953706: 96953706
12 GUCA1A NM_000409.4(GUCA1A): c.296A> G (p.Tyr99Cys) single nucleotide variant Pathogenic/Likely pathogenic rs104893967 GRCh37 Chromosome 6, 42146112: 42146112
13 BBS1 NM_024649.4(BBS1): c.1169T> G (p.Met390Arg) single nucleotide variant Pathogenic/Likely pathogenic rs113624356 GRCh37 Chromosome 11, 66293652: 66293652
14 RHO NM_000539.3(RHO): c.1040C> T (p.Pro347Leu) single nucleotide variant Pathogenic/Likely pathogenic rs29001566 GRCh37 Chromosome 3, 129252554: 129252554
15 RHO NM_000539.3(RHO): c.403C> T (p.Arg135Trp) single nucleotide variant Pathogenic rs104893775 GRCh37 Chromosome 3, 129249760: 129249760
16 RHO NM_000539.3(RHO): c.158C> G (p.Pro53Arg) single nucleotide variant Pathogenic/Likely pathogenic rs28933395 GRCh37 Chromosome 3, 129247734: 129247734
17 RHO NM_000539.3(RHO): c.568G> T (p.Asp190Tyr) single nucleotide variant Pathogenic/Likely pathogenic rs104893779 GRCh37 Chromosome 3, 129251131: 129251131
18 RHO NM_000539.3(RHO): c.44A> G (p.Asn15Ser) single nucleotide variant Pathogenic rs104893786 GRCh37 Chromosome 3, 129247620: 129247620
19 RLBP1 NM_000326.4(RLBP1): c.677T> A (p.Met226Lys) single nucleotide variant Pathogenic/Likely pathogenic rs137853291 GRCh37 Chromosome 15, 89754981: 89754981
20 PDE6B NM_000283.3(PDE6B): c.892C> T (p.Gln298Ter) single nucleotide variant Pathogenic rs121918579 GRCh37 Chromosome 4, 647908: 647908
21 PDE6B NM_000283.3(PDE6B): c.1669C> T (p.His557Tyr) single nucleotide variant Pathogenic rs121918581 GRCh37 Chromosome 4, 655977: 655977
22 RPE65 NM_000329.2(RPE65): c.1543C> T (p.Arg515Trp) single nucleotide variant Pathogenic rs121917745 GRCh37 Chromosome 1, 68895518: 68895518
23 ABCA4 NM_000350.2(ABCA4): c.3364G> A (p.Glu1122Lys) single nucleotide variant Pathogenic/Likely pathogenic rs61751399 GRCh37 Chromosome 1, 94506923: 94506923
24 USH2A NM_206933.2(USH2A): c.8559-2A> G single nucleotide variant Pathogenic rs397518039 GRCh37 Chromosome 1, 216051224: 216051224
25 USH2A NM_206933.2(USH2A): c.8981G> A (p.Trp2994Ter) single nucleotide variant Pathogenic rs397518041 GRCh37 Chromosome 1, 216019240: 216019240
26 USH2A NM_206933.2(USH2A): c.920_923dupGCCA (p.His308Glnfs) duplication Pathogenic rs397518043 GRCh37 Chromosome 1, 216498867: 216498870
27 COL18A1 NM_130445.3(COL18A1): c.3514_3515delCT (p.Leu1172Valfs) deletion Pathogenic/Likely pathogenic rs398122391 GRCh37 Chromosome 21, 46930005: 46930006
28 EYS NM_001142800.1(EYS): c.7095T> G (p.Tyr2365Ter) single nucleotide variant Pathogenic rs398123575 GRCh37 Chromosome 6, 64574212: 64574212
29 CNGB1 NM_001297.4(CNGB1): c.952C> T (p.Gln318Ter) single nucleotide variant Pathogenic/Likely pathogenic rs372504780 GRCh37 Chromosome 16, 57984367: 57984367
30 PRPH2 NM_000322.4(PRPH2): c.736T> C (p.Trp246Arg) single nucleotide variant Pathogenic rs61755817 GRCh37 Chromosome 6, 42672195: 42672195
31 RPE65 NM_000329.2(RPE65): c.118G> A (p.Gly40Ser) single nucleotide variant Pathogenic rs61751281 GRCh37 Chromosome 1, 68912520: 68912520
32 ABCA4 NM_000350.2(ABCA4): c.4537dupC (p.Gln1513Profs) duplication Pathogenic/Likely pathogenic rs281865377 GRCh37 Chromosome 1, 94495003: 94495003
33 PDE6B NM_000283.3(PDE6B): c.1467+1G> C single nucleotide variant Pathogenic rs527236089 GRCh37 Chromosome 4, 652807: 652807
34 PDE6B NM_000283.3(PDE6B): c.1604T> A (p.Ile535Asn) single nucleotide variant Pathogenic rs527236088 GRCh37 Chromosome 4, 654392: 654392
35 PRPH2 NM_000322.4(PRPH2): c.410G> A (p.Gly137Asp) single nucleotide variant Pathogenic rs527236097 GRCh37 Chromosome 6, 42689663: 42689663
36 PRPH2 NM_000322.4(PRPH2): c.499G> A (p.Gly167Ser) single nucleotide variant Pathogenic/Likely pathogenic rs527236098 GRCh37 Chromosome 6, 42689574: 42689574
37 ROM1 NM_000327.3(ROM1): c.331dupG (p.Leu114Alafs) duplication Pathogenic rs527236104 GRCh38 Chromosome 11, 62613612: 62613612
38 RHO NM_000539.3(RHO): c.520G> A (p.Gly174Ser) single nucleotide variant Pathogenic rs527236103 GRCh37 Chromosome 3, 129249877: 129249877
39 RHO NM_000539.3(RHO): c.562G> A (p.Gly188Arg) single nucleotide variant Pathogenic rs527236100 GRCh37 Chromosome 3, 129251125: 129251125
40 CRX NM_000554.5(CRX): c.193G> C (p.Asp65His) single nucleotide variant Pathogenic rs527236062 GRCh38 Chromosome 19, 47836335: 47836335
41 PRCD NM_001077620.2(PRCD): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs527236092 GRCh37 Chromosome 17, 74536225: 74536225
42 CNGA1 NM_001142564.1(CNGA1): c.398delG (p.Gly133Valfs) deletion Pathogenic/Likely pathogenic rs527236058 GRCh37 Chromosome 4, 47953415: 47953415
43 EYS NM_001142800.1(EYS): c.4957dupA (p.Ser1653Lysfs) duplication Pathogenic rs527236065 GRCh38 Chromosome 6, 64590910: 64590910
44 EYS NM_001142800.1(EYS): c.6557G> A (p.Gly2186Glu) single nucleotide variant Pathogenic rs527236068 GRCh37 Chromosome 6, 64791763: 64791763
45 EYS NM_001142800.1(EYS): c.7793G> A (p.Gly2598Asp) single nucleotide variant Pathogenic rs527236064 GRCh37 Chromosome 6, 64488004: 64488004
46 EYS NM_001142800.1(EYS): c.7919G> A (p.Trp2640Ter) single nucleotide variant Pathogenic rs527236066 GRCh37 Chromosome 6, 64472506: 64472506
47 EYS NM_001142800.1(EYS): c.8805C> A (p.Tyr2935Ter) single nucleotide variant Pathogenic rs527236067 GRCh37 Chromosome 6, 64431122: 64431122
48 EYS NM_001142800.1(EYS): c.9209T> C (p.Ile3070Thr) single nucleotide variant Pathogenic rs183589498 GRCh37 Chromosome 6, 64430718: 64430718
49 BEST1 NM_004183.3(BEST1): c.763C> T (p.Arg255Trp) single nucleotide variant Pathogenic rs372989281 GRCh38 Chromosome 11, 61958194: 61958194
50 TOPORS NM_005802.4(TOPORS): c.2554_2557delGAGA (p.Glu852Glnfs) deletion Pathogenic rs527236116 GRCh37 Chromosome 9, 32541966: 32541969

Expression for Rhyns Syndrome

Search GEO for disease gene expression data for Rhyns Syndrome.

Pathways for Rhyns Syndrome

GO Terms for Rhyns Syndrome

Cellular components related to Rhyns Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.95 BBS10 C2orf71 PROM1 RP1 RPGR TULP1
2 cilium GO:0005929 9.73 BBS10 C2orf71 PROM1 RP1 RPGR TULP1
3 ciliary basal body GO:0036064 9.63 RPGR TOPORS USH2A
4 photoreceptor connecting cilium GO:0032391 9.61 RP1 TOPORS USH2A
5 photoreceptor disc membrane GO:0097381 9.5 PDE6A PDE6B RHO
6 Golgi-associated vesicle membrane GO:0030660 9.48 CNGB1 RHO
7 photoreceptor outer segment membrane GO:0042622 9.46 CNGA1 PROM1 RHO ROM1
8 photoreceptor inner segment membrane GO:0060342 9.37 RDH12 RHO
9 photoreceptor inner segment GO:0001917 9.35 C2orf71 RHO RP1 TULP1 USH2A
10 photoreceptor outer segment GO:0001750 9.32 C2orf71 CNGA1 CNGB1 PRCD PROM1 PRPH2

Biological processes related to Rhyns Syndrome according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.83 BBS10 C2orf71 CLRN1 CNGA1 CNGB1 PDE6A
2 retina development in camera-type eye GO:0060041 9.8 PDE6B PRPH2 RHO RP1 RPE65 TULP1
3 regulation of rhodopsin mediated signaling pathway GO:0022400 9.77 CNGA1 CNGB1 PDE6A PDE6B RHO
4 retina homeostasis GO:0001895 9.76 BBS10 CNGB1 RPE65 TULP1
5 retinoid metabolic process GO:0001523 9.75 RDH12 RHO RPE65
6 retina morphogenesis in camera-type eye GO:0060042 9.73 PROM1 ROM1 RP1 RPE65
7 regulation of cytosolic calcium ion concentration GO:0051480 9.71 CNGB1 PDE6A PDE6B
8 photoreceptor cell outer segment organization GO:0035845 9.71 C2orf71 CNGB1 RP1 TOPORS
9 detection of light stimulus involved in visual perception GO:0050908 9.69 CNGB1 RPE65 TULP1
10 sensory perception of light stimulus GO:0050953 9.67 CLRN1 RHO USH2A
11 phototransduction, visible light GO:0007603 9.65 PDE6B RHO RP1
12 rhodopsin mediated signaling pathway GO:0016056 9.65 CNGA1 CNGB1 PDE6A PDE6B RHO
13 response to light stimulus GO:0009416 9.61 RHO RPE65
14 retina layer formation GO:0010842 9.61 PROM1 TOPORS
15 GMP metabolic process GO:0046037 9.6 PDE6A PDE6B
16 retinal rod cell development GO:0046548 9.59 RP1 TOPORS
17 retinal cone cell development GO:0046549 9.58 RP1 TOPORS
18 protein localization to photoreceptor outer segment GO:1903546 9.57 C2orf71 TULP1
19 camera-type eye photoreceptor cell differentiation GO:0060219 9.56 PROM1 ROM1
20 cellular response to light stimulus GO:0071482 9.55 RHO RP1
21 detection of light stimulus GO:0009583 9.52 PDE6B RHO
22 photoreceptor cell maintenance GO:0045494 9.28 BBS10 CLRN1 CNGB1 PROM1 RDH12 RHO
23 visual perception GO:0007601 10.09 BBS10 C2orf71 CLRN1 CNGA1 CNGB1 PDE6A

Molecular functions related to Rhyns Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cGMP binding GO:0030553 9.16 CNGA1 CNGB1
2 3,5-cyclic-GMP phosphodiesterase activity GO:0047555 8.96 PDE6A PDE6B
3 intracellular cyclic nucleotide activated cation channel activity GO:0005221 8.62 CNGA1 CNGB1

Sources for Rhyns Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....