MCID: RGH001
MIFTS: 34

Right Bundle Branch Block malady

Summaries for Right Bundle Branch Block

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63Wikipedia, 32MalaCards
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Wikipedia:63 A right bundle branch block (RBBB) is a defect in the heart\'s electrical conduction system. more...

MalaCards: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome and congenital heart block. An important gene associated with Right Bundle Branch Block is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are SIDS Susceptibility Pathways and Sodium channels and transporters: inward current. The compounds verapamil and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Aliases & Classifications for Right Bundle Branch Block

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

right bundle branch block 8 10 44 60
right bundle branch block with left posterior fascicular block 8


External Ids:

Disease Ontology8 DOID:13209
SNOMED-CT56 46319007
ICD9CM27 426.51

Related Diseases for Right Bundle Branch Block

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Clinical Features for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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32MalaCards
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MalaCards organs/tissues related to Right Bundle Branch Block:

32
Heart, Testes, Spinal cord, Atrioventricular node

Animal Models for Right Bundle Branch Block or affiliated genes

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Publications for Right Bundle Branch Block

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50PubMed
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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Ventricular fibrillation associated with complete right bundle branch block. (23499623)
2013
2
Usefulness of multimodality imaging on detecting plaque rupture in septal myocardial infarction associated with right bundle branch block. (24411916)
2013
3
Verrucous epidermal naevus and naevus spilus associated with lower limb asymmetry and right bundle-branch block: a case of phacomatosis pigmentokeratotica? (21790731)
2012
4
Right bundle branch block as a marker for interatrial septal abnormalities. (21729501)
2012
5
New electrocardiographic criteria for discriminating between Brugada types 2 and 3 patterns and incomplete right bundle branch block. (22093505)
2011
6
Cardiac resynchronization therapy in patients with left ventricular systolic dysfunction and right bundle branch block: a systematic review. (21300176)
2011
7
Second-degree 2:1 atrioventricular block with right bundle-branch block: what is the mechanism? (20969976)
2011
8
A new criteria differentiating type 2 and 3 Brugada patterns from ordinary incomplete right bundle branch block. (21646738)
2011
9
Prolongation of QRS duration and axis deviation in the right bundle branch block are not markers for left ventricular systolic dysfunction. (22477595)
2010
10
Septal branch aneurysm during coronary computed tomography angiography: a cause of right bundle branch block? (18820323)
2009
11
Clinical and angiographic importance of right bundle branch block in the setting of acute anterior myocardial infarction. (18400632)
2008
12
Alternating left bundle branch block and right bundle branch block during tachycardia: what is the mechanism? (17467642)
2007
13
Acute right bundle branch block as a presenting sign of acute pulmonary embolism. (16931712)
2006
14
Can ST-segment changes be evaluated for acute myocardial injury in a patient with right bundle branch block? (15785170)
2005
15
True right bundle branch block masking the typical ECG in Brugada syndrome. (15733192)
2005
16
The successful treatment of end stage of heart failure associated with complete right bundle branch block with biventricular pacemaker placement. (15216920)
2004
17
Pulmonary hypertension due to spontaneous premature ductal constriction in fetal life: association with right bundle branch block. (12636008)
2002
18
Appearance of right bundle branch block in electrocardiograms of patients with pulmonary embolism as a marker for obstruction of the main pulmonary trunk. (11455507)
2001
19
Right bundle branch block, right precordial st-segment elevation, and sudden death in young people. (11156883)
2001
20
Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V(1)to V(3)and sudden death. (10653680)
2000
21
Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block. (9555768)
1998
22
Right bundle branch block, persistent ST-segment elevation in V1-V3 and sudden cardiac death: always a distinct syndrome? (8529854)
1995
23
Incidence and electrocardiographic localization of safe right bundle branch block configurations during permanent ventricular pacing. (7572654)
1995
24
ECG of the month. High-grade second-degree AV block and right bundle-branch block in a cat. (7961067)
1994
25
Ventricular tachycardia of right bundle-branch block--left axis deviation morphology and organic heart disease. (1617830)
1992
26
Risk of right bundle-branch block and complete heart block during pulmonary artery catheterization. (2909309)
1989
27
Complete right bundle branch block (CRBBB) with three different mean frontal plane QRS axes--a case report. (3408026)
1988
28
Electrocardiographic standard for the diagnosis of right ventricular hypertrophy in complete right bundle branch block. (2974677)
1987
29
The early signs of right bundle branch block. (3967525)
1985
30
EKG of the month: right bundle branch block associated with cardiac rejection. (3906277)
1985
31
Right bundle branch block in a prospective population study. (6617210)
1983
32
Significance of complete right bundle-branch block when an isolated finding. An echocardiographic study. (7104112)
1982
33
Wolff-Parkinson-White syndrome type B with tachycardia-dependent (phase 3) block in the accessory pathway and in left bundle-branch coexisting with rate-unrelated right bundle-branch block. (7397051)
1980
34
Postoperative right bundle branch block: identification of three levels of block. (7397974)
1980
35
Site of functional right bundle branch block. (7446362)
1980
36
Right bundle branch block with Wenckebach conduction. (252505)
1979
37
Left anterior hemiblock obscuring the diagnosis of right bundle branch block in acute myocardial infarction. (445729)
1979
38
The risk of advanced heart block in surgical patients with right bundle branch block and left axis deviation. (630675)
1978
39
Correlative studies on electrocardiogram and histopathology of the conduction system. (1) Right bundle branch block with left axis deviation and prolonged P-R interval. (886657)
1977
40
Phasic aberrant ventricular conduction manifesting as right bundle branch block with left anterior hemiblock. (1039989)
1975
41
Surgically induced right bundle-branch block with left anterior hemiblock. An ominous sign in postoperative tetralogy of Fallot. (5071742)
1972
42
A-V and trifasicular block: high-grade A-V block, idionodal escape rhythm with right bundle branch block and intermittent left anterior and posterior hemiblocks. (4265569)
1972
43
Right bundle-branch block associated with left superior or inferior intraventricular block. Clinical setting, prognosis, and relation to complete heart block. (5492543)
1970
44
Vectorcardiographic study of QRS loop in patients with left superior axis deviation and right bundle-branch block. (4246191)
1970
45
Right bundle branch block with marked left axis deviation. A variant of bilateral bundle branch block. (5368361)
1969
46
Transient post-traumatic right bundle branch block. Report of two cases. (5785166)
1969
47
Character, cause, and consequence of combined left axis deviation and right bundle branch block in human electrocardiograms. (5773736)
1969
48
Evaluation of the magnitude of the R' in V1 in detecting right ventricular hypertrophy in the presence of complete right bundle-branch block. (4240921)
1969
49
Association of right bundle-branch block with left superior or inferior intraventricular block. Its relation to complete heart block and Adams-Stokes syndrome. (5791121)
1969
50
The form of the electrocardiogram in anteroseptal myocardial infarction complicated by right and left bundle branch block. (20272817)
1947

Genetic Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Right Bundle Branch Block

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Pathways for genes affiliated with Right Bundle Branch Block

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37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 29KEGG
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Pathways related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GPD1L, SCN5A
29.5TRPM4, SCN5A
39.4SCN5A, CACNA1C
49.3TRPM4, CACNA1C

Compounds for genes affiliated with Right Bundle Branch Block

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1verapamil44 49 28 11 2413.1SCN5A, CACNA1C
2calcium44 49 11 2411.4TRPM4, C9orf3, SCN5A, CACNA1C

GO Terms for genes affiliated with Right Bundle Branch Block

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16Gene Ontology
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Biological processes related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell membrane depolarizationGO:0603739.6GPD1L, SCN5A
2regulation of heart rateGO:0020279.6GPD1L, SCN5A
3positive regulation of sodium ion transportGO:0107659.5GPD1L, SCN5A
4regulation of ventricular cardiac muscle cell action potentialGO:0860059.3GPD1L, SCN5A

Molecular functions related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.6GPD1L, SCN5A
2calmodulin bindingGO:0055168.6TRPM4, SCN5A, CACNA1C

Products for genes affiliated with Right Bundle Branch Block

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Sources for Right Bundle Branch Block

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet