MCID: RGH001
MIFTS: 34

Right Bundle Branch Block malady

Summaries for Right Bundle Branch Block

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63Wikipedia, 32MalaCards
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Wikipedia:63 A right bundle branch block (RBBB) is a defect in the heart\'s electrical conduction system. more...

MalaCards: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome and congenital heart block. An important gene associated with Right Bundle Branch Block is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are SIDS Susceptibility Pathways and Sodium channels and transporters: inward current. The compounds verapamil and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Aliases & Classifications for Right Bundle Branch Block

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

right bundle branch block 8 10 44 60
right bundle branch block with left posterior fascicular block 8


External Ids:

Disease Ontology8 DOID:13209
SNOMED-CT56 46319007
ICD9CM27 426.51

Related Diseases for Right Bundle Branch Block

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Clinical Features for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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32MalaCards
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MalaCards organs/tissues related to Right Bundle Branch Block:

32
Heart, Testes, Spinal cord, Atrioventricular node

Animal Models for Right Bundle Branch Block or affiliated genes

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Publications for Right Bundle Branch Block

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50PubMed
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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study. (22947613)
2013
2
The mischievous bundle: a case of varying degrees of right bundle branch block on alternate beats during exercise stress testing. (23714091)
2013
3
Effect on cardiac function of cardiac resynchronization therapy in patients with right bundle branch block (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT] trial). (23725995)
2013
4
Distinguishing incomplete right bundle branch block in patients with arrhythmogenic right ventricular cardiomyopathy from normal variants: a potential role of Fontaine leads and Holter monitoring? (22459394)
2012
5
Incomplete right bundle branch block: a novel electrocardiographic marker for lone atrial fibrillation. (21138928)
2011
6
In-hospital outcome in patients with ST elevation myocardial infarction and right bundle branch block. A sub-study from RENASICA II, a national multicenter registry. (21147580)
2010
7
Atrial septal aneurysm associated with additional cardiovascular comorbidities in two middle age female patients with ECG signs of right bundle branch block: two case reports. (18638415)
2008
8
Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis. (16815572)
2007
9
Usefulness of either or both left and right bundle branch block at baseline or during follow-up for predicting death in patients following acute myocardial infarction. (17317365)
2007
10
Right bundle branch block: a new parameter revealing the progression rate of mitral stenosis. (16508261)
2006
11
ECG of the month. Reality check. Complicated right bundle branch block. (11394324)
2001
12
Brugada syndrome: the syndrome of right bundle branch block, ST segment elevation in V1 to V3 and sudden death. (17006566)
2001
13
Facilitation of atrioventricular reentrant tachycardia by iatrogenic right bundle branch block. (11453585)
2001
14
A young man with recurrent syncopes, right bundle branch block and ST segment elevation. (10530545)
1999
15
Adenosine-induced right bundle branch block in a patient with recurrent tachycardia. (9272542)
1997
16
Electrocardiographic abnormalities in right ventricular infarction associated with right bundle branch block. (9215235)
1997
17
Familial cardiomyopathy associated with right bundle branch block, ST segment elevation and sudden death. (8800140)
1996
18
Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. (8557918)
1996
19
Integral curves and the variational principle of intermittent normal conduction in the tachycardia-dependent right bundle branch block. (9088128)
1996
20
Diagnosis of right ventricular overload by body surface QRST isointegral maps in children with postoperative right bundle branch block. (7595123)
1995
21
Sudden collapse with new right bundle branch block. (8132725)
1994
22
Diagnostic and prognostic accuracy of the exercise electrocardiogram in patients with preexisting right bundle branch block. (8197978)
1994
23
Frequency and significance of right bundle branch block after cardiac transplantation. (8184837)
1994
24
Impaired subsidiary pacemaker function in patients with a right bundle branch block created prior to complete catheter ablation of the AV junction. (8472717)
1993
25
Radiofrequency catheter ablation of idiopathic recurrent ventricular tachycardia with right bundle branch block, left axis morphology. (7680462)
1993
26
Ventricular standstill complicating left heart catheterization in the presence of uncomplicated right bundle branch block. (1306060)
1992
27
Evolution of right bundle branch block and other intraventricular conduction abnormalities in the transplanted human heart. (2266575)
1990
28
Intraventricular conduction disturbances in flying personnel: incomplete right bundle branch block. (3190624)
1988
29
Characteristics and prognosis of incomplete right bundle branch block: an epidemiologic study. (3950228)
1986
30
Right ventricular papillary muscle electrography. Analysis of the site of surgically induced right bundle branch block using a temporary ventricular pacing electrode. (6471390)
1984
31
Left atrial abnormality as an electrocardiographic criterion for the diagnosis of left ventricular hypertrophy in the presence of right bundle branch block. (6223523)
1983
32
Right bundle branch block: long-term prognosis in apparently healthy men. (6826977)
1983
33
Right bundle branch block reflecting balloon inflation of Swan-Ganz catheter. (7056113)
1982
34
Experimental appraisal for diagnosis of right bundle branch block using the body surface isopotential maps. (7218503)
1981
35
Is right bundle branch block aviodable in surgical correction of tetralogy of Fallot? (7408157)
1980
36
Body surface map patterns of altered depolarization and repolarization in right bundle branch block. (7353254)
1980
37
Transient right bundle branch block during His bundle electrogram in a case with ventricular parasystole. (432503)
1979
38
Avoidance of right-bundle-branch block in correction of tetralogy of Fallot. (692621)
1978
39
Right bundle branch block with periods of alternating left anterior and left posterior hemiblock. Clinical evidence of incomplete fascicular block. (727567)
1978
40
Transient unifascicular, bifasicular and trifascicular block: electrophysiologic correlations in a patient with rate-dependent left bundle branch block and transient right bundle branch block. (137668)
1977
41
About the significance of right bundle branch block in chest wall deformity patients. (835426)
1977
42
Genesis of body surface potential distribution in right bundle branch block. (881606)
1977
43
Right bundle branch block. (1141692)
1975
44
Complete right bundle branch block with left axis deviations: significance of vectorcardiographic morphology. (4268305)
1973
45
Electrocardiogram and vectorcardiogram in isolated complete right bundle branch block. I. Clinical studies. (4800824)
1973
46
Postsurgical left anterior hemiblock and right bundle-branch block. (5015022)
1972
47
Left anterior hemiblock and right bundle branch block before and after surgical repair of tetralogy of Fallot. (4263484)
1972
48
Study of right bundle-branch block in association with either left anterior hemiblock or left posterior hemiblock using His bundle electrograms. (5070111)
1972
49
Stokes-Adams attacks due to Mobitz II block in a patient with left axis deviation and right bundle branch block. (4991243)
1970
50
Right bundle branch block after nonpenetrating injury to the chest wall. (5818310)
1969

Genetic Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Right Bundle Branch Block

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Pathways for genes affiliated with Right Bundle Branch Block

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37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 29KEGG
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Pathways related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GPD1L, SCN5A
29.5TRPM4, SCN5A
39.4SCN5A, CACNA1C
49.3TRPM4, CACNA1C

Compounds for genes affiliated with Right Bundle Branch Block

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1verapamil44 49 28 11 2413.1SCN5A, CACNA1C
2calcium44 49 11 2411.4TRPM4, C9orf3, SCN5A, CACNA1C

GO Terms for genes affiliated with Right Bundle Branch Block

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16Gene Ontology
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Biological processes related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell membrane depolarizationGO:0603739.6GPD1L, SCN5A
2regulation of heart rateGO:0020279.6GPD1L, SCN5A
3positive regulation of sodium ion transportGO:0107659.5GPD1L, SCN5A
4regulation of ventricular cardiac muscle cell action potentialGO:0860059.3GPD1L, SCN5A

Molecular functions related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.6GPD1L, SCN5A
2calmodulin bindingGO:0055168.6TRPM4, SCN5A, CACNA1C

Products for genes affiliated with Right Bundle Branch Block

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Sources for Right Bundle Branch Block

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet