MCID: RGH001
MIFTS: 35

Right Bundle Branch Block malady

Cardiovascular diseases category

Aliases & Classifications for Right Bundle Branch Block

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Aliases & Descriptions for Right Bundle Branch Block:

Name: Right Bundle Branch Block 10 47 12 65
Right Bundle Branch Block with Left Posterior Fascicular Block 10
 
Right Bundle Branch Block and Left Posterior Fascicular Block 65


Classifications:



External Ids:

Disease Ontology10 DOID:13209
SNOMED-CT59 46319007
ICD9CM29 426.51

Summaries for Right Bundle Branch Block

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Wikipedia:68 A right bundle branch block (RBBB) is a heart block in the electrical conduction system. more...

MalaCards based summary: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome 2 and brugada syndrome 1. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Channel, Voltage Gated, Type V Alpha Subunit), and among its related pathways are NCAM1 interactions and Celecoxib Pathway, Pharmacodynamics. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotype cardiovascular system.

Related Diseases for Right Bundle Branch Block

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Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1brugada syndrome 231.0GPD1L, SCN5A
2brugada syndrome 130.3CACNA1C, SCN3B, SCN5A
3myocardial infarction11.2
4acute myocardial infarction11.1
5brugada syndrome10.9
6tetralogy of fallot10.9
7cardiomyopathy10.9
8ventricular septal defect10.8
9heart block, progressive, type ia10.8
10atrial fibrillation10.8
11atrioventricular block10.7
12congestive heart failure10.7
13arrhythmogenic right ventricular cardiomyopathy10.7
14congenital heart disease10.7
15pulmonary embolism10.7
16sudden cardiac death10.7
17aneurysm10.7
18wolff-parkinson-white syndrome10.6
19artery disease10.6
20coronary artery disease10.6
21coronary heart disease 310.6
22hypertrophic cardiomyopathy10.6
23inferior myocardial infarction10.6
24anteroseptal myocardial infarction10.6
25atrial septal aneurysm10.6
26coronary heart disease 210.5
27coronary heart disease 510.5
28coronary heart disease 610.5
29coronary heart disease 410.5
30progressive familial heart block, type ib10.5
31congenital heart block10.5
32heart valve disease10.5
33single ventricular heart10.5
34chagas disease10.5
35dextrocardia10.5
36systolic heart failure10.5
37heart conduction disease10.5
38ischemia10.5
39muscular dystrophy10.5
40pulmonary valve disease10.5
41second-degree atrioventricular block10.5
42tricuspid valve disease10.5
43syncope10.5
44rheumatoid arthritis10.3
45brugada syndrome 910.3
46progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 210.3
47hepatocellular carcinoma10.3
48cardiomyopathy, dilated, 1e10.3
49glycogen storage disease xv10.3
50ventricular septal defect 310.3

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Symptoms for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) IndicationRecruitingNCT01415024Phase 4
2Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic PatientsCompletedNCT00550459Phase 3
3MADIT ASIA Cardiac Resynchronization TrialTerminatedNCT01872234Phase 3
4Right Bundle Branch Block After Surgical Closure of Ventricular Septal DefectCompletedNCT01480908
5Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)CompletedNCT01169493
6The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and EfficiencyCompletedNCT00704093
7Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular CharacterizationRecruitingNCT00173342
8Predicting Hypoglycaemia and Arrythmias in the Vulnerable Patient With Diabetes and Chronic Kidney DiseaseRecruitingNCT02315300
9Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on ElectrocardiogramRecruitingNCT00453700
10QT Interval in Patients With Pacemaker DependencyRecruitingNCT01694550
11Efficacy and Safety of Multisite Cardiac Resynchronization TherapyRecruitingNCT01966016
12Left Ventricular Function and Remodelling During Permanent PacingActive, not recruitingNCT00228241
13Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial)Enrolling by invitationNCT02441101
14Selective Coronary Vein Sampling in Left Bundle Branch Block and CRTNot yet recruitingNCT02396875
15High Septal Pacing for Cardiac Resynchronization TherapyTerminatedNCT01325480Phase 0
16MIRACLE EF Clinical StudyTerminatedNCT01735916

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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MalaCards organs/tissues related to Right Bundle Branch Block:

33
Heart, Testes, Atrioventricular node, Spinal cord

Animal Models for Right Bundle Branch Block or affiliated genes

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MGI Mouse Phenotypes related to Right Bundle Branch Block:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.0CACNA1C, CACNB2, HCN4, KCND3, SCN3B, SCN5A

Publications for Right Bundle Branch Block

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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Erratum to: Does Surgically Induced Right Bundle Branch Block Really Effect Ventricular Function in Children After Ventricular Septal Defect Closure? (25795310)
2015
2
Clinical and electrocardiographic characteristics of idiopathic ventricular arrhythmias with right bundle branch block and superior axis: Comparison of apical crux area and posterior septal left ventricle. (25728755)
2015
3
The mechanism of the resolution of chronic right bundle branch block during acute myocardial infarction. (26022426)
2015
4
Cardiac metastasis causing right bundle branch block and recurrent septal ventricular tachycardia. (24612005)
2014
5
Alternating left and right bundle branch block. (25343679)
2014
6
Right Bundle Branch Block Affecting the Morphology of Septal Right Ventricular Outflow Tract Premature Ventricular Beats. (25640296)
2014
7
Does Surgically Induced Right Bundle Branch Block Really Effect Ventricular Function in Children After Ventricular Septal Defect Closure? (25293427)
2014
8
Ventricular fibrillation associated with complete right bundle branch block. (23499623)
2013
9
Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block. (23739544)
2013
10
Right bundle branch block with changing axis at the end of atrial fibrillation. (20961632)
2012
11
Verrucous epidermal naevus and naevus spilus associated with lower limb asymmetry and right bundle-branch block: a case of phacomatosis pigmentokeratotica? (21790731)
2012
12
Special features of right bundle branch block in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. (22036093)
2012
13
Biventricular pacing worsened dyssynchrony in heart failure patient with right-bundle branch block. (18706707)
2010
14
Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects. (18390536)
2008
15
Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis. (16815572)
2007
16
Right bundle branch block pattern during right ventricular permanent pacing: Is it safe or not? (17684578)
2007
17
Prediction of mortality in patients with right bundle branch block referred for pharmacologic stress echocardiography. (14675579)
2003
18
Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. (11772879)
2002
19
The syndrome of right bundle branch block, ST segment elevation in V1 to V3 and sudden death. (12085974)
2002
20
Incidence and prognostic significance of right bundle branch block complicating acute myocardial infarction. (12587758)
2002
21
ECG of the month. Reality check. Complicated right bundle branch block. (11394324)
2001
22
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. (10662748)
2000
23
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. (11076825)
2000
24
Right bundle-branch block, ST-segment elevation, and sudden death. (10779476)
2000
25
The significance of a new right bundle branch block in a patient with acute chest pain. (10569395)
1999
26
Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block. (9555768)
1998
27
Adenosine-induced right bundle branch block in a patient with recurrent tachycardia. (9272542)
1997
28
Incidence and prognostic significance of right bundle branch block in patients with acute myocardial infarction receiving thrombolytic therapy. (9314206)
1997
29
Right bundle branch block of unknown age in the setting of acute anterior myocardial infarction: an attempt to define who should be paced prophylactically. (7479171)
1995
30
Electrocardiographic diagnosis of left ventricular hypertrophy in the presence of right bundle branch block in cases with essential hypertension. (8129183)
1994
31
Loss of late potentials after radiofrequency catheter ablation of recurrent ventricular tachycardia in a patient with right bundle branch block. (7511238)
1994
32
Reversible thallium-201 perfusion defects in right bundle branch block and normal coronary angiogram. (8315507)
1993
33
Ventricular standstill complicating left heart catheterization in the presence of uncomplicated right bundle branch block. (1306060)
1992
34
Electrocardiographic standard for the diagnosis of right ventricular hypertrophy in complete right bundle branch block. (2974677)
1987
35
Left anterior hemiblock masking the diagnosis of right bundle branch block. (3805961)
1986
36
Emergency evaluation of the EKG right bundle branch block. (4086779)
1985
37
Right ventricular papillary muscle electrography. Analysis of the site of surgically induced right bundle branch block using a temporary ventricular pacing electrode. (6471390)
1984
38
Right bundle branch block in complete transposition. (6229498)
1984
39
Newly acquired right bundle-branch block. (7427128)
1980
40
Newly acquired right bundle-branch block: The Framingham Study. (7350871)
1980
41
Resolution of surgically induced right bundle-branch block. (836102)
1977
42
Right bundle branch block and tonometric studies in practically healthy youngsters. (835425)
1977
43
Vectorcardiographic study of right bundle branch block and its associations with the left hemiblocks. (1274756)
1976
44
Right bundle branch block-its clinical significance. (1151182)
1975
45
The site of functional right bundle branch block in the intact canine heart. (1136874)
1975
46
Ballistocardiographic aid in thyrotoxic complete right bundle branch block (TRBBB). (4802407)
1973
47
An electrocardiographic study on the electrical axis of right bundle branch block in the aged. (4545778)
1973
48
Cycle length-dependent left and right bundle branch block and left anterior hemiblock. (5020259)
1972
49
Right bundle-branch block associated with left superior or inferior intraventricular block associated with acute myocardial infarction. (5492544)
1970
50
Right bundle branch block with marked left axis deviation. A variant of bilateral bundle branch block. (5368361)
1969

Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for genes affiliated with Right Bundle Branch Block

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GO Terms for genes affiliated with Right Bundle Branch Block

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Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intercalated discGO:001470410.3SCN1B, SCN5A
2voltage-gated calcium channel complexGO:00058919.8CACNA1C, CACNB2
3T-tubuleGO:00303159.7CACNA1C, SCN1B, SCN5A
4voltage-gated sodium channel complexGO:00015189.4SCN1B, SCN2B, SCN3B, SCN5A
5Z discGO:00300188.7CACNA1C, SCN3B, SCN5A
6sarcolemmaGO:00423838.7CACNA1C, CACNB2, KCND3, SCN5A
7plasma membraneGO:00058867.1CACNA1C, GPD1L, HCN4, KCND3, SCN3B, SCN5A

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.4SCN1B, SCN5A
2membrane depolarization during Purkinje myocyte cell action potentialGO:008604710.4SCN1B, SCN5A
3positive regulation of heart rateGO:001046010.0SCN3B, SCN5A
4regulation of ventricular cardiac muscle cell membrane depolarizationGO:00603739.9GPD1L, SCN3B, SCN5A
5ventricular cardiac muscle cell action potentialGO:00860059.9GPD1L, SCN3B, SCN5A
6cardiac conductionGO:00613379.9SCN1B, SCN3B, TRPM4
7calcium ion importGO:00705099.8CACNA1C, CACNB2
8membrane depolarizationGO:00518999.7SCN1B, SCN3B, SCN5A
9sodium ion transportGO:00068149.7SCN1B, SCN3B, SCN5A
10positive regulation of sodium ion transportGO:00107659.5GPD1L, SCN1B, SCN3B, SCN5A
11membrane depolarization during action potentialGO:00860109.5CACNA1C, SCN3B, SCN5A
12SA node cell action potentialGO:00860159.5HCN4, SCN3B, SCN5A
13regulation of atrial cardiac muscle cell membrane depolarizationGO:00603719.4SCN1B, SCN2B, SCN3B, SCN5A
14cardiac muscle cell action potential involved in contractionGO:00860029.4SCN1B, SCN2B, SCN3B, SCN5A
15regulation of sodium ion transmembrane transporter activityGO:20006499.4GPD1L, SCN1B, SCN2B, SCN3B
16membrane depolarization during cardiac muscle cell action potentialGO:00860129.4SCN1B, SCN2B, SCN3B, SCN5A
17calcium ion transmembrane transportGO:00705889.2CACNA1C, CACNB2, TRPM4
18regulation of ion transmembrane transportGO:00347658.8CACNA1C, HCN4, KCND3, SCN5A
19cardiac muscle contractionGO:00600488.8SCN1B, SCN2B, SCN3B, SCN5A
20regulation of heart rateGO:00020278.7GPD1L, HCN4, SCN5A
21sodium ion transmembrane transportGO:00357258.5HCN4, SCN1B, SCN2B, SCN3B, SCN5A
22axon guidanceGO:00074118.5CACNA1C, CACNB2, SCN1B, SCN5A
23regulation of heart rate by cardiac conductionGO:00860918.5HCN4, SCN1B, SCN2B, SCN3B, SCN5A
24ion transportGO:00068118.4CACNA1C, HCN4, KCND3, SCN5A, TRPM4
25transmembrane transportGO:00550858.3CACNA1C, HCN4, KCND3, SCN5A, TRPM4
26synaptic transmissionGO:00072687.4CACNA1C, CACNB2, HCN4, KCND3, SCN1B, SCN2B

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activity involved in Purkinje myocyte action potentialGO:008606210.3SCN1B, SCN5A
2high voltage-gated calcium channel activityGO:00083319.6CACNA1C, CACNB2
3voltage-gated calcium channel activityGO:00052459.6CACNA1C, CACNB2
4calmodulin bindingGO:00055169.4CACNA1C, SCN5A, TRPM4
5calcium channel activityGO:00052629.3CACNB2, TRPM4
6voltage-gated sodium channel activity involved in cardiac muscle cell action potentialGO:00860069.3SCN1B, SCN2B, SCN3B, SCN5A
7sodium channel regulator activityGO:00170809.3GPD1L, SCN1B, SCN2B, SCN3B
8protein domain specific bindingGO:00199049.0CACNA1C, CACNB2, SCN5A
9ion channel bindingGO:00443259.0GPD1L, KCND3, SCN3B, SCN5A
10voltage-gated sodium channel activityGO:00052488.5HCN4, SCN1B, SCN2B, SCN3B, SCN5A
11ion channel activityGO:00052168.2CACNA1C, HCN4, KCND3, SCN5A, TRPM4

Sources for Right Bundle Branch Block

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet