MCID: RGH001
MIFTS: 36

Right Bundle Branch Block malady

Cardiovascular diseases category

Summaries for Right Bundle Branch Block

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66Wikipedia, 34MalaCards
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Wikipedia:66 A right bundle branch block (RBBB) is a defect in the heart\'s electrical conduction system. more...

MalaCards: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome and long qt syndrome. An important gene associated with Right Bundle Branch Block is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are SIDS Susceptibility Pathways and Sodium channels and transporters inward current. The compounds verapamil and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Aliases & Classifications for Right Bundle Branch Block

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

right bundle branch block 9 11 46 63
right bundle branch block with left posterior fascicular block 9


External Ids:

Disease Ontology9 DOID:13209
SNOMED-CT59 46319007
ICD9CM28 426.51

Related Diseases for Right Bundle Branch Block

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Symptoms for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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34MalaCards
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MalaCards organs/tissues related to Right Bundle Branch Block:

34
Heart, Testes, Spinal cord, Atrioventricular node

Animal Models for Right Bundle Branch Block or affiliated genes

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Publications for Right Bundle Branch Block

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53PubMed
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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Ventricular fibrillation associated with complete right bundle branch block. (23499623)
2013
2
Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block. (23739544)
2013
3
Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study. (22947613)
2013
4
Storms of ventricular fibrillation responsive to isoproterenol in an idiopathic ventricular fibrillation patient demonstrating complete right bundle branch block. (23924939)
2013
5
Right bundle branch block with changing axis at the end of atrial fibrillation. (20961632)
2012
6
Verrucous epidermal naevus and naevus spilus associated with lower limb asymmetry and right bundle-branch block: a case of phacomatosis pigmentokeratotica? (21790731)
2012
7
Special features of right bundle branch block in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. (22036093)
2012
8
Biventricular pacing worsened dyssynchrony in heart failure patient with right-bundle branch block. (18706707)
2010
9
Characteristics of bundle branch reentrant ventricular tachycardia with a right bundle branch block configuration: feasibility of atrial pacing. (19661115)
2009
10
Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects. (18390536)
2008
11
Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis. (16815572)
2007
12
Right bundle branch block pattern during right ventricular permanent pacing: Is it safe or not? (17684578)
2007
13
Prevalence of right bundle-branch block and right precordial ST-segment elevation (Brugada-type electrocardiogram) in Japanese children. (15056820)
2004
14
Prediction of mortality in patients with right bundle branch block referred for pharmacologic stress echocardiography. (14675579)
2003
15
Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. (11772879)
2002
16
The syndrome of right bundle branch block, ST segment elevation in V1 to V3 and sudden death. (12085974)
2002
17
Incidence and prognostic significance of right bundle branch block complicating acute myocardial infarction. (12587758)
2002
18
Posterior myocardial infarction and complete right bundle- branch block. (12426296)
2002
19
ECG of the month. Reality check. Complicated right bundle branch block. (11394324)
2001
20
Brugada syndrome: the syndrome of right bundle branch block, ST segment elevation in V1 to V3 and sudden death. (17006566)
2001
21
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. (10662748)
2000
22
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. (11076825)
2000
23
Right bundle-branch block, ST-segment elevation, and sudden death. (10779476)
2000
24
The significance of a new right bundle branch block in a patient with acute chest pain. (10569395)
1999
25
Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block. (9555768)
1998
26
Adenosine-induced right bundle branch block in a patient with recurrent tachycardia. (9272542)
1997
27
Incidence and prognostic significance of right bundle branch block in patients with acute myocardial infarction receiving thrombolytic therapy. (9314206)
1997
28
Right bundle branch block, persistent ST-segment elevation in V1-V3 and sudden cardiac death: always a distinct syndrome? (8529854)
1995
29
Right bundle branch block of unknown age in the setting of acute anterior myocardial infarction: an attempt to define who should be paced prophylactically. (7479171)
1995
30
Electrocardiographic diagnosis of left ventricular hypertrophy in the presence of right bundle branch block in cases with essential hypertension. (8129183)
1994
31
Loss of late potentials after radiofrequency catheter ablation of recurrent ventricular tachycardia in a patient with right bundle branch block. (7511238)
1994
32
Reversible thallium-201 perfusion defects in right bundle branch block and normal coronary angiogram. (8315507)
1993
33
Ventricular standstill complicating left heart catheterization in the presence of uncomplicated right bundle branch block. (1306060)
1992
34
Electrocardiographic standard for the diagnosis of right ventricular hypertrophy in complete right bundle branch block. (2974677)
1987
35
Left anterior hemiblock masking the diagnosis of right bundle branch block. (3805961)
1986
36
Emergency evaluation of the EKG right bundle branch block. (4086779)
1985
37
Right ventricular papillary muscle electrography. Analysis of the site of surgically induced right bundle branch block using a temporary ventricular pacing electrode. (6471390)
1984
38
Right bundle branch block in complete transposition. (6229498)
1984
39
Newly acquired right bundle-branch block. (7427128)
1980
40
Newly acquired right bundle-branch block: The Framingham Study. (7350871)
1980
41
Resolution of surgically induced right bundle-branch block. (836102)
1977
42
Right bundle branch block and tonometric studies in practically healthy youngsters. (835425)
1977
43
Vectorcardiographic study of right bundle branch block and its associations with the left hemiblocks. (1274756)
1976
44
Right bundle branch block-its clinical significance. (1151182)
1975
45
The site of functional right bundle branch block in the intact canine heart. (1136874)
1975
46
Ballistocardiographic aid in thyrotoxic complete right bundle branch block (TRBBB). (4802407)
1973
47
An electrocardiographic study on the electrical axis of right bundle branch block in the aged. (4545778)
1973
48
Cycle length-dependent left and right bundle branch block and left anterior hemiblock. (5020259)
1972
49
Right bundle-branch block associated with left superior or inferior intraventricular block associated with acute myocardial infarction. (5492544)
1970
50
Right bundle branch block with marked left axis deviation. A variant of bilateral bundle branch block. (5368361)
1969

Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Right Bundle Branch Block

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Pathways for genes affiliated with Right Bundle Branch Block

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51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome, 31KEGG, 52PharmGKB, 54QIAGEN
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Compounds for genes affiliated with Right Bundle Branch Block

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46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1verapamil46 30 52 25 1213.4CACNA1C, SCN5A
2calcium46 52 25 1211.1TRPM4, CACNA1C, C9orf3, SCN5A

GO Terms for genes affiliated with Right Bundle Branch Block

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17Gene Ontology
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Cellular components related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.5TRPM4, CACNA1C, SCN5A, GPD1L

Biological processes related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell membrane depolarizationGO:0603739.6SCN5A, GPD1L
2regulation of heart rateGO:0020279.6SCN5A, GPD1L
3positive regulation of sodium ion transportGO:0107659.5SCN5A, GPD1L
4ventricular cardiac muscle cell action potentialGO:0860059.3SCN5A, GPD1L

Molecular functions related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.6SCN5A, GPD1L
2calmodulin bindingGO:0055168.6TRPM4, CACNA1C, SCN5A

Products for genes affiliated with Right Bundle Branch Block

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Sources for Right Bundle Branch Block

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet