MCID: RGH001
MIFTS: 41

Right Bundle Branch Block malady

Category: Cardiovascular diseases

Aliases & Classifications for Right Bundle Branch Block

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Aliases & Descriptions for Right Bundle Branch Block:

Name: Right Bundle Branch Block 10 47 12 65
 
Right Bundle Branch Block with Left Posterior Fascicular Block 10

Classifications:



External Ids:

Disease Ontology10 DOID:13209
SNOMED-CT59 46319007
ICD9CM29 426.51
UMLS65 C0155704, C0085615

Summaries for Right Bundle Branch Block

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Wikipedia:68 A right bundle branch block (RBBB) is a heart block in the electrical conduction system. more...

MalaCards based summary: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome 2 and brugada syndrome 3. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways are SIDS Susceptibility Pathways and Netrin Signaling. Affiliated tissues include heart, lung and breast, and related mouse phenotype cardiovascular system.

Related Diseases for Right Bundle Branch Block

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Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1brugada syndrome 230.9GPD1L, SCN5A
2brugada syndrome 329.8CACNA1C, CACNB2
3brugada syndrome 129.8CACNA1C, SCN3B, SCN5A, TRPM4
4progressive familial heart block, type ib11.9
5brugada syndrome11.8
6myocardial infarction10.9
7acute myocardial infarction10.7
8tetralogy of fallot10.5
9cardiomyopathy10.5
10heart block, progressive, type ia10.5
11ventricular septal defect10.4
12atrial fibrillation10.4
13atrial fibrillation, familial, 1310.4SCN1B, SCN5A
14arrhythmogenic right ventricular cardiomyopathy10.4
15atrioventricular block10.4
16pulmonary embolism10.4
17ventricular fibrillation, familial, 110.3CACNA1C, SCN5A
18heart disease10.3
19sudden cardiac death10.3
20aneurysm10.3
21wolff-parkinson-white syndrome10.3
22artery disease10.3
23brugada syndrome 910.3
24brugada syndrome 410.3
25brugada syndrome 610.3
26brugada syndrome 710.3
27brugada syndrome 810.3
28brugada syndrome 510.3
29porokeratotic eccrine ostial and dermal duct nevus10.2HCN4, SCN5A
30coronary artery disease10.2
31congestive heart failure10.2
32second-degree atrioventricular block10.2
33hypertrophic cardiomyopathy10.2
34inferior myocardial infarction10.2
35anteroseptal myocardial infarction10.2
36atrial septal aneurysm10.2
37immunoglobulin a vasculitis10.2CACNA1C, SCN5A
38familial pulmonary arterial hypertension leucopenia and atrial septal defect10.2SCN1B, SCN5A, TRPM4
39endocardium disease10.1HCN4, SCN5A
40chagas disease10.1
41ischemia10.1
42septal myocardial infarction10.1
43dextrocardia10.1
44muscular dystrophy10.1
45syncope10.1
46first-degree atrioventricular block10.0HCN4, SCN5A
47rheumatoid arthritis10.0
48pulmonary hypertension10.0
49arthritis10.0
50spinal cord injury10.0

Comorbidity relations with Right Bundle Branch Block via Phenotypic Disease Network (PDN):

(show all 30)
Atrioventricular BlockBenign Essential Hypertension
Chronic Pulmonary Heart DiseaseCoronary Artery Disease
Deficiency AnemiaFirst-Degree Atrioventricular Block
Hypertension, EssentialIntermediate Coronary Syndrome
Ischemic Heart DiseaseLeft Bundle Branch Hemiblock
Left Ventricular Outflow Tract ObstructionMitral Valve Disease
Mobitz Type Ii Atrioventricular BlockPulmonary Hypertension
Acute CystitisBronchitis
EsophagitisFamilial Atrial Fibrillation
Generalized AtherosclerosisHeart Block, Progressive, Type Ia
Heart Conduction DiseaseHeart Disease
Peripheral Vascular DiseasePostinflammatory Pulmonary Fibrosis
Prostatic HypertrophyRespiratory Failure
Sinoatrial Node DiseaseTransient Cerebral Ischemia
Third-Degree Atrioventricular BlockTricuspid Valve Disease

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Symptoms for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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Drugs for Right Bundle Branch Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TolvaptanapprovedPhase 384150683-30-0216237, 443894
Synonyms:
( -)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide
150683-30-0
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
AC1L50C9
C116664
CHEBI:327437
CHEMBL344159
CID216237
 
L001628
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
OPC 41061
OPC-41061
PDSP1_001738
PDSP2_001721
Samsca
Tolvaptan
UNII-21G72T1950
benzazepine derivative, 32
2VasopressinsPhase 3260
3Natriuretic AgentsPhase 31403
4HormonesPhase 311748
5Arginine VasopressinPhase 3264

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) IndicationRecruitingNCT01415024Phase 4
2Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic PatientsCompletedNCT00550459Phase 3
3MADIT ASIA Cardiac Resynchronization TrialTerminatedNCT01872234Phase 3
4Right Bundle Branch Block After Surgical Closure of Ventricular Septal DefectCompletedNCT01480908
5Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)CompletedNCT01169493
6The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and EfficiencyCompletedNCT00704093
7Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular CharacterizationRecruitingNCT00173342
8Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney DiseaseRecruitingNCT02315300
9Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on ElectrocardiogramRecruitingNCT00453700
10QT Interval in Patients With Pacemaker DependencyRecruitingNCT01694550
11Efficacy and Safety of Multisite Cardiac Resynchronization TherapyRecruitingNCT01966016
12Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency DepartmentRecruitingNCT02781207
13Left Ventricular Function and Remodelling During Permanent PacingActive, not recruitingNCT00228241
14Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial)Enrolling by invitationNCT02441101
15Selective Coronary Vein Sampling in Left Bundle Branch Block and CRTNot yet recruitingNCT02396875
16High Septal Pacing for Cardiac Resynchronization TherapyTerminatedNCT01325480Phase 0
17MIRACLE EF Clinical StudyTerminatedNCT01735916

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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MalaCards organs/tissues related to Right Bundle Branch Block:

33
Heart, Lung, Breast, Bone, Kidney, Prostate, Eye

Animal Models for Right Bundle Branch Block or affiliated genes

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MGI Mouse Phenotypes related to Right Bundle Branch Block:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053856.9CACNA1C, CACNB2, HCN4, KCND3, SCN3B, SCN5A

Publications for Right Bundle Branch Block

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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Exercise left ventricular ejection fraction predicts events in right bundle branch block. (26634337)
2016
2
Comorbidities of Chronic Complete Right Bundle Branch Block and Correlations With Coronary Angiographic Findings. (26802764)
2016
3
Prognostic Significance of Right Bundle Branch Block for Patients with Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. (27017617)
2016
4
Clinical and electrocardiographic characteristics of idiopathic ventricular arrhythmias with right bundle branch block and superior axis: Comparison of apical crux area and posterior septal left ventricle. (25728755)
2015
5
The mechanism of the resolution of chronic right bundle branch block during acute myocardial infarction. (26022426)
2015
6
Cardiac metastasis causing right bundle branch block and recurrent septal ventricular tachycardia. (24612005)
2014
7
Alternating left and right bundle branch block. (25343679)
2014
8
Right Bundle Branch Block Affecting the Morphology of Septal Right Ventricular Outflow Tract Premature Ventricular Beats. (25640296)
2014
9
Does Surgically Induced Right Bundle Branch Block Really Effect Ventricular Function in Children After Ventricular Septal Defect Closure? (25293427)
2014
10
Ventricular fibrillation associated with complete right bundle branch block. (23499623)
2013
11
Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block. (23739544)
2013
12
Right bundle branch block with changing axis at the end of atrial fibrillation. (20961632)
2012
13
Verrucous epidermal naevus and naevus spilus associated with lower limb asymmetry and right bundle-branch block: a case of phacomatosis pigmentokeratotica? (21790731)
2012
14
Special features of right bundle branch block in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. (22036093)
2012
15
Biventricular pacing worsened dyssynchrony in heart failure patient with right-bundle branch block. (18706707)
2010
16
Significance of QRS morphology in determining the prevalence of mechanical dyssynchrony in heart failure patients eligible for cardiac resynchronization: particular focus on patients with right bundle branch block with and without coexistent left-sided conduction defects. (18390536)
2008
17
Right bundle-branch block in anterior acute myocardial infarction in the coronary intervention era: acute angiographic findings and prognosis. (16815572)
2007
18
Right bundle branch block pattern during right ventricular permanent pacing: Is it safe or not? (17684578)
2007
19
Prediction of mortality in patients with right bundle branch block referred for pharmacologic stress echocardiography. (14675579)
2003
20
Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. (11772879)
2002
21
The syndrome of right bundle branch block, ST segment elevation in V1 to V3 and sudden death. (12085974)
2002
22
ECG of the month. Reality check. Complicated right bundle branch block. (11394324)
2001
23
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. (10662748)
2000
24
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. (11076825)
2000
25
Right bundle-branch block, ST-segment elevation, and sudden death. (10779476)
2000
26
The significance of a new right bundle branch block in a patient with acute chest pain. (10569395)
1999
27
Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block. (9555768)
1998
28
Adenosine-induced right bundle branch block in a patient with recurrent tachycardia. (9272542)
1997
29
Incidence and prognostic significance of right bundle branch block in patients with acute myocardial infarction receiving thrombolytic therapy. (9314206)
1997
30
Right bundle branch block, persistent ST-segment elevation in V1-V3 and sudden cardiac death: always a distinct syndrome? (8529854)
1995
31
Right bundle branch block of unknown age in the setting of acute anterior myocardial infarction: an attempt to define who should be paced prophylactically. (7479171)
1995
32
Electrocardiographic diagnosis of left ventricular hypertrophy in the presence of right bundle branch block in cases with essential hypertension. (8129183)
1994
33
Loss of late potentials after radiofrequency catheter ablation of recurrent ventricular tachycardia in a patient with right bundle branch block. (7511238)
1994
34
Reversible thallium-201 perfusion defects in right bundle branch block and normal coronary angiogram. (8315507)
1993
35
Ventricular standstill complicating left heart catheterization in the presence of uncomplicated right bundle branch block. (1306060)
1992
36
Electrocardiographic standard for the diagnosis of right ventricular hypertrophy in complete right bundle branch block. (2974677)
1987
37
Left anterior hemiblock masking the diagnosis of right bundle branch block. (3805961)
1986
38
Emergency evaluation of the EKG right bundle branch block. (4086779)
1985
39
Right ventricular papillary muscle electrography. Analysis of the site of surgically induced right bundle branch block using a temporary ventricular pacing electrode. (6471390)
1984
40
Newly acquired right bundle-branch block. (7427128)
1980
41
Newly acquired right bundle-branch block: The Framingham Study. (7350871)
1980
42
Resolution of surgically induced right bundle-branch block. (836102)
1977
43
Right bundle branch block and tonometric studies in practically healthy youngsters. (835425)
1977
44
Vectorcardiographic study of right bundle branch block and its associations with the left hemiblocks. (1274756)
1976
45
Right bundle branch block-its clinical significance. (1151182)
1975
46
The site of functional right bundle branch block in the intact canine heart. (1136874)
1975
47
Ballistocardiographic aid in thyrotoxic complete right bundle branch block (TRBBB). (4802407)
1973
48
Cycle length-dependent left and right bundle branch block and left anterior hemiblock. (5020259)
1972
49
Right bundle-branch block associated with left superior or inferior intraventricular block associated with acute myocardial infarction. (5492544)
1970
50
Right bundle branch block with marked left axis deviation. A variant of bilateral bundle branch block. (5368361)
1969

Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for genes affiliated with Right Bundle Branch Block

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Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.3GPD1L, SCN3B, SCN5A
29.2CACNA1C, CACNB2
39.2CACNA1C, CACNB2
49.2CACNA1C, CACNB2
5
Show member pathways
8.9SCN1B, SCN2B, SCN3B, SCN5A
6
Show member pathways
8.9SCN1B, SCN2B, SCN3B, SCN5A
78.9SCN1B, SCN2B, SCN3B, SCN5A
88.6CACNA1C, CACNB2, KCND3
9
Show member pathways
8.5CACNA1C, CACNB2, SCN1B, SCN5A
10
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
11
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
12
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
13
Show member pathways
7.0CACNA1C, CACNB2, KCND3, SCN1B, SCN2B, SCN3B
14
Show member pathways
7.0CACNA1C, CACNB2, KCND3, SCN1B, SCN2B, SCN3B
156.4CACNA1C, CACNB2, HCN4, KCND3, SCN1B, SCN2B

GO Terms for genes affiliated with Right Bundle Branch Block

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Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.8SCN1B, SCN5A

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1membrane depolarization during Purkinje myocyte cell action potentialGO:008604710.4SCN1B, SCN5A
2positive regulation of sodium ion transportGO:001076510.4GPD1L, SCN5A
3regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.4SCN1B, SCN5A
4cardiac muscle cell action potential involved in contractionGO:008600210.3SCN3B, SCN5A
5regulation of postsynaptic membrane potentialGO:006007810.3SCN2B, SCN5A
6regulation of ion transmembrane transportGO:003476510.2CACNA1C, SCN5A
7regulation of atrial cardiac muscle cell membrane depolarizationGO:006037110.1SCN2B, SCN3B
8sodium ion transmembrane transportGO:003572510.0HCN4, TRPM4
9membrane depolarizationGO:00518999.9SCN3B, SCN5A
10ventricular cardiac muscle cell action potentialGO:00860059.9GPD1L, SCN3B, SCN5A
11SA node cell action potentialGO:00860159.7HCN4, SCN3B, SCN5A
12positive regulation of heart rateGO:00104609.6SCN3B, TRPM4
13regulation of sodium ion transmembrane transporter activityGO:20006499.3GPD1L, SCN1B, SCN2B, SCN3B
14calcium ion transmembrane transportGO:00705889.1CACNA1C, CACNB2, TRPM4
15membrane depolarization during cardiac muscle cell action potentialGO:00860129.0CACNA1C, SCN1B, SCN2B, SCN3B, SCN5A
16ion transportGO:00068118.9CACNA1C, HCN4, SCN5A, TRPM4
17cardiac conductionGO:00613378.6CACNA1C, CACNB2, SCN1B, SCN3B
18synaptic transmissionGO:00072688.6CACNB2, SCN1B, SCN2B
19axon guidanceGO:00074118.5CACNA1C, CACNB2, SCN1B, SCN5A
20regulation of heart rate by cardiac conductionGO:00860918.2CACNA1C, HCN4, SCN1B, SCN2B, SCN3B, SCN5A

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:00052489.9HCN4, SCN5A
2protein domain specific bindingGO:00199049.4CACNB2, SCN5A
3voltage-gated calcium channel activity involved in AV node cell action potentialGO:00860569.1CACNA1C, CACNB2

Sources for Right Bundle Branch Block

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet