MCID: RGH001
MIFTS: 22

Right Bundle Branch Block malady

Summaries for Right Bundle Branch Block

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64Wikipedia, 33MalaCards
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Wikipedia:64 A right bundle branch block (RBBB) is a defect in the heart\'s electrical conduction system. more...

MalaCards: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome and congenital heart block. An important gene associated with Right Bundle Branch Block is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are SIDS Susceptibility Pathways and Sodium channels and transporters: inward current. The compounds verapamil and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart.

Aliases & Classifications for Right Bundle Branch Block

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
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Aliases & Descriptions:

right bundle branch block 8 10 45 61
right bundle branch block with left posterior fascicular block 8


External Ids:

Disease Ontology8 DOID:13209
SNOMED-CT57 46319007
ICD9CM27 426.51

Related Diseases for Right Bundle Branch Block

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Clinical Features for Right Bundle Branch Block

Drugs & Therapeutics for Right Bundle Branch Block

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Right Bundle Branch Block

Anatomical Context for Right Bundle Branch Block

Sources:
33MalaCards
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MalaCards organs/tissues related to Right Bundle Branch Block:

33
Heart

Animal Models for Right Bundle Branch Block or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Right Bundle Branch Block

Genetic Variations for Right Bundle Branch Block

Expression for genes affiliated with Right Bundle Branch Block

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Right Bundle Branch Block

Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for genes affiliated with Right Bundle Branch Block

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 30KEGG
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Pathways related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GPD1L, SCN5A
29.5TRPM4, SCN5A
39.4SCN5A, CACNA1C
49.3TRPM4, CACNA1C

Compounds for genes affiliated with Right Bundle Branch Block

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1verapamil45 50 29 11 2413.1SCN5A, CACNA1C
2calcium45 50 11 2411.4TRPM4, C9orf3, SCN5A, CACNA1C

GO Terms for genes affiliated with Right Bundle Branch Block

Sources:
16Gene Ontology
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Biological processes related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell membrane depolarizationGO:0603739.6GPD1L, SCN5A
2regulation of heart rateGO:0020279.6GPD1L, SCN5A
3positive regulation of sodium ion transportGO:0107659.5GPD1L, SCN5A
4regulation of ventricular cardiac muscle cell action potentialGO:0860059.3GPD1L, SCN5A

Molecular functions related to Right Bundle Branch Block according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.6GPD1L, SCN5A
2calmodulin bindingGO:0055168.6TRPM4, SCN5A, CACNA1C

Products for genes affiliated with Right Bundle Branch Block

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Right Bundle Branch Block

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet