MCID: RGH001
MIFTS: 38

Right Bundle Branch Block malady

Category: Cardiovascular diseases

Aliases & Classifications for Right Bundle Branch Block

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Aliases & Descriptions for Right Bundle Branch Block:

Name: Right Bundle Branch Block 10 47 12 65
 
Right Bundle Branch Block with Left Posterior Fascicular Block 10

Classifications:



External Ids:

Disease Ontology10 DOID:13209
SNOMED-CT59 46319007
ICD9CM29 426.51
UMLS65 C0155704, C0085615

Summaries for Right Bundle Branch Block

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Wikipedia:68 A right bundle branch block (RBBB) is a heart block in the electrical conduction system. more...

MalaCards based summary: Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome 2 and brugada syndrome 3. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways are SIDS Susceptibility Pathways and Netrin Signaling. Affiliated tissues include heart, breast and kidney, and related mouse phenotype cardiovascular system.

Related Diseases for Right Bundle Branch Block

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Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to right bundle branch block

Symptoms for Right Bundle Branch Block

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Drugs & Therapeutics for Right Bundle Branch Block

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Drugs for Right Bundle Branch Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TolvaptanapprovedPhase 384150683-30-0216237, 443894
Synonyms:
( -)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide
150683-30-0
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
AC1L50C9
C116664
CHEBI:327437
CHEMBL344159
CID216237
 
L001628
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
OPC 41061
OPC-41061
PDSP1_001738
PDSP2_001721
Samsca
Tolvaptan
UNII-21G72T1950
benzazepine derivative, 32
2VasopressinsPhase 3260
3Natriuretic AgentsPhase 31403
4HormonesPhase 311748
5Arginine VasopressinPhase 3264

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) IndicationRecruitingNCT01415024Phase 4
2Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic PatientsCompletedNCT00550459Phase 3
3MADIT ASIA Cardiac Resynchronization TrialTerminatedNCT01872234Phase 3
4Right Bundle Branch Block After Surgical Closure of Ventricular Septal DefectCompletedNCT01480908
5Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)CompletedNCT01169493
6The Effect of Right Ventricular Pacing on Myocardial Oxidative Metabolism and EfficiencyCompletedNCT00704093
7Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular CharacterizationRecruitingNCT00173342
8Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney DiseaseRecruitingNCT02315300
9Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on ElectrocardiogramRecruitingNCT00453700
10QT Interval in Patients With Pacemaker DependencyRecruitingNCT01694550
11Efficacy and Safety of Multisite Cardiac Resynchronization TherapyRecruitingNCT01966016
12Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency DepartmentRecruitingNCT02781207
13Left Ventricular Function and Remodelling During Permanent PacingActive, not recruitingNCT00228241
14Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial)Enrolling by invitationNCT02441101
15Selective Coronary Vein Sampling in Left Bundle Branch Block and CRTNot yet recruitingNCT02396875
16High Septal Pacing for Cardiac Resynchronization TherapyTerminatedNCT01325480Phase 0
17MIRACLE EF Clinical StudyTerminatedNCT01735916

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Genetic Tests for Right Bundle Branch Block

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Anatomical Context for Right Bundle Branch Block

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MalaCards organs/tissues related to Right Bundle Branch Block:

33
Heart, Breast, Kidney, Bone, Liver, Skin, Lung

Animal Models for Right Bundle Branch Block or affiliated genes

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MGI Mouse Phenotypes related to Right Bundle Branch Block:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053856.9CACNA1C, CACNB2, HCN4, KCND3, SCN3B, SCN5A

Publications for Right Bundle Branch Block

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Articles related to Right Bundle Branch Block:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Behavioral and cognitive outcomes for clinical trials in children with neurofibromatosis type 1. (27164720)
2016
2
Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells. (25849377)
2015
3
Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis. (25172542)
2015
4
Effect of induced peritoneal endometriosis on oocyte and embryo quality in a mouse model. (25399065)
2014
5
Is gestational diabetes mellitus an independent risk factor for macrosomia: a meta-analysis? (25388922)
2014
6
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
7
Prophylactic Central Neck Dissection Increases the Cost of Thyroid Cancer Care. (24100961)
2013
8
Tinea nigra and dermoscopy. (22309345)
2012
9
Sialolithiasis in a 10 year old child. (23257494)
2012
10
Relapsed lymphoma preceded by cold agglutinin disease. (22611566)
2012
11
The cadherin-catenin complex in laryngeal squamous cell carcinoma. (22197995)
2012
12
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease. (19897004)
2010
13
Retroperitoneal extragonadal endodermal sinus tumor with bilateral diffuse classic testicular microlithiasis. (21098858)
2010
14
A case of high-grade leiomyosarcoma of the bladder with delayed onset and very poor prognosis. (20302611)
2010
15
Successful outcome of accidental ethylene glycol poisoning despite delayed presentation. (22767560)
2010
16
Adiponectin in chronic kidney disease: Dr Jekyll and Mr Hyde. (19092822)
2009
17
Swallowing disorders in the first year after radiation and chemoradiation. (17786992)
2008
18
Idiopathic normal pressure hydrocephalus: increased supplementary motor activity accounts for improvement after CSF drainage. (18931387)
2008
19
Bradykinin B1 receptor antagonists as novel analgesics: a retrospective of selected medicinal chemistry developments. (18991728)
2008
20
Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations. (18032122)
2007
21
Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. (17908689)
2007
22
Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. (16368133)
2006
23
Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes. (16824933)
2006
24
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer. (15170665)
2004
25
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. (15039704)
2004
26
Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method. (15601584)
2004
27
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. (12653650)
2003
28
Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. (11754077)
2002
29
QUASIMODO1 encodes a putative membrane-bound glycosyltransferase required for normal pectin synthesis and cell adhesion in Arabidopsis. (12368506)
2002
30
Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor beta. (12372420)
2002
31
Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis. (11567663)
2001
32
Lack of PMS2 gene-truncating mutations in patients with hereditary colorectal cancer. (9683794)
1998
33
Epitope and mimotope for an antibody to the Na, K-ATPase. (9232655)
1997
34
The relationship between the gene mutation of p53 and the protein expression of p53 and Ki-67 in non-Hodgkin's lymphomas. (10846560)
1996
35
Are growth factors leukemogenic? (8558925)
1996
36
Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. (8964400)
1996
37
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
38
Desmopressin acetate does not reduce blood loss during total hip replacement in patients receiving dextran. (7572006)
1995
39
Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. (8537914)
1995
40
Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. (7798535)
1994
41
Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (8439553)
1993
42
Therapeutic effects of simultaneous use of glucose and insulin in ketotic dairy cows. (8436669)
1993
43
Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. (8099450)
1993
44
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
45
Rapid one-step sandwich enzyme immunoassay for tissue inhibitor of metalloproteinases. An application for rheumatoid arthritis serum and plasma. (2181021)
1990
46
Indomethacin-responsive pancreatic cholera. (197410)
1977
47
Free full thickness skin graft urethroplasty for urethral stricture: experience with 66 patients. (781311)
1976
48
Correction of the skeletal anomalies of oto-mandibular dysostosis. (4533024)
1974
49
The Lesch-Nyhan syndrome: report of three cases. (4502719)
1972
50
Balanitis due to fixed drug eruption associated with tetracycline therapy. (4251608)
1971

Variations for Right Bundle Branch Block

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Expression for genes affiliated with Right Bundle Branch Block

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Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for genes affiliated with Right Bundle Branch Block

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Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.3GPD1L, SCN3B, SCN5A
29.2CACNA1C, CACNB2
39.2CACNA1C, CACNB2
49.2CACNA1C, CACNB2
5
Show member pathways
8.9SCN1B, SCN2B, SCN3B, SCN5A
6
Show member pathways
8.9SCN1B, SCN2B, SCN3B, SCN5A
78.9SCN1B, SCN2B, SCN3B, SCN5A
88.6CACNA1C, CACNB2, KCND3
9
Show member pathways
8.5CACNA1C, CACNB2, SCN1B, SCN5A
10
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
11
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
12
Show member pathways
7.6CACNA1C, CACNB2, SCN1B, SCN2B, SCN3B, SCN5A
13
Show member pathways
7.0CACNA1C, CACNB2, KCND3, SCN1B, SCN2B, SCN3B
14
Show member pathways
7.0CACNA1C, CACNB2, KCND3, SCN1B, SCN2B, SCN3B
156.4CACNA1C, CACNB2, HCN4, KCND3, SCN1B, SCN2B

GO Terms for genes affiliated with Right Bundle Branch Block

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Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.8SCN1B, SCN5A

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1membrane depolarization during Purkinje myocyte cell action potentialGO:008604710.4SCN1B, SCN5A
2positive regulation of sodium ion transportGO:001076510.4GPD1L, SCN5A
3regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.4SCN1B, SCN5A
4cardiac muscle cell action potential involved in contractionGO:008600210.3SCN3B, SCN5A
5regulation of postsynaptic membrane potentialGO:006007810.3SCN2B, SCN5A
6regulation of ion transmembrane transportGO:003476510.2CACNA1C, SCN5A
7regulation of atrial cardiac muscle cell membrane depolarizationGO:006037110.1SCN2B, SCN3B
8sodium ion transmembrane transportGO:003572510.0HCN4, TRPM4
9membrane depolarizationGO:00518999.9SCN3B, SCN5A
10ventricular cardiac muscle cell action potentialGO:00860059.9GPD1L, SCN3B, SCN5A
11SA node cell action potentialGO:00860159.7HCN4, SCN3B, SCN5A
12positive regulation of heart rateGO:00104609.6SCN3B, TRPM4
13regulation of sodium ion transmembrane transporter activityGO:20006499.3GPD1L, SCN1B, SCN2B, SCN3B
14calcium ion transmembrane transportGO:00705889.1CACNA1C, CACNB2, TRPM4
15membrane depolarization during cardiac muscle cell action potentialGO:00860129.0CACNA1C, SCN1B, SCN2B, SCN3B, SCN5A
16ion transportGO:00068118.9CACNA1C, HCN4, SCN5A, TRPM4
17cardiac conductionGO:00613378.6CACNA1C, CACNB2, SCN1B, SCN3B
18synaptic transmissionGO:00072688.6CACNB2, SCN1B, SCN2B
19axon guidanceGO:00074118.5CACNA1C, CACNB2, SCN1B, SCN5A
20regulation of heart rate by cardiac conductionGO:00860918.2CACNA1C, HCN4, SCN1B, SCN2B, SCN3B, SCN5A

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:00052489.9HCN4, SCN5A
2protein domain specific bindingGO:00199049.4CACNB2, SCN5A
3voltage-gated calcium channel activity involved in AV node cell action potentialGO:00860569.1CACNA1C, CACNB2

Sources for Right Bundle Branch Block

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet