Ritter's Disease malady

Disease Ontology: A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus staphylococcus (s. aureus). the infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.⁶

MalaCards: Ritter's Disease, also known as pemphigus neonatorum, is related to toxic epidermal necrolysis and netherton syndrome, and has symptoms including fluid-filled blister formation, fever and irritability. An important gene associated with Ritter's Disease is AGR3 (anterior gradient 3 homolog (Xenopus laevis)). The compounds pd 145065 and sitaxsentan have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Descriptions:

ritter's disease 6 pemphigus neonatorum 6 43 toxic epidermal necrolysis, subcorneal type (disorder) 6 staphylococcal scalded skin syndrome (disorder) 6 staphylococcal scalded skin syndrome 43

dermatitis exfoliativa neonatorum 6 toxic epidermal necrolysis 43 scalded skin syndrome 6 ritters disease 8

Diseases related to ritter's disease by text searches and GeneDecks gene sharing:

(show all 37)

id	Related Disease	Score	Top Affiliating Genes
1	toxic epidermal necrolysis	29.8	DSG1, EDNRB, EDNRA
2	netherton syndrome	29.5	EDNRA, DSG1
3	pemphigus	28.8	DSG1, DSG3, DSG4
4	impetigo	26.7	DSG4, DSG3, DSG1, AGR3, EDNRB, EDNRA
5	subcorneal pustular dermatosis	12.7	DSG1, DSG3
6	bullous skin disease	12.7	DSG3, DSG1
7	multiple self healing squamous epithelioma	12.7	DSG3, DSG1
8	follicular dendritic cell sarcoma	12.7	DSG1, DSG3
9	hailey-hailey disease	12.6	DSG3, DSG1
10	epidermolysis bullosa acquisita	12.6	DSG3, DSG1
11	dendritic cell sarcoma	12.6	DSG1, DSG3
12	bullous pemphigoid	12.5	DSG1, DSG3
13	exfoliation syndrome	12.5	EDNRA, EDNRB
14	cystic kidney	12.5	EDNRB, EDNRA
15	impotence	12.4	EDNRB, EDNRA
16	vulvar cancer	12.4	EDNRA, EDNRB
17	migraine with aura	12.4	EDNRB, EDNRA
18	keratoacanthoma	12.3	DSG3, DSG1
19	mixed connective tissue disease	12.3	DSG1, EDNRA
20	polycystic kidney disease, autosomal dominant	12.3	EDNRB, EDNRA
21	pemphigus foliaceus	12.3	DSG1, DSG3, DSG4
22	pemphigus vulgaris	12.3	DSG1, DSG3, DSG4
23	connective tissue disease	12.3	IBSP, EDNRA, DSG1
24	varicocele	12.1	EDNRA, EDNRB
25	tonsillitis	11.8	DSG3, DSG1, EDNRA, HSF4
26	toxic shock syndrome	11.8	EDNRB, EDNRA, SUMF2, GML
27	prostate colloid adenocarcinoma	11.8	IBSP, EDNRA, EDNRB
28	skin disease	11.6	DSG1, DSG3, DSG4
29	stevens-johnson syndrome	11.5
30	lung carcinoma	11.4	IBSP, EDNRA, EDNRB, DSG1
31	squamous cell carcinoma	11.1	IBSP, EDNRB, DSG1, DSG3
32	erythema multiforme	9.0
33	graft versus host disease	7.6
34	pancytopenia	7.6
35	anemia	7.6
36	aplastic anemia	7.6
37	molluscum contagiosum	6.9

Symptoms: fluid-filled blister formation, fever, irritability.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ritter's disease:

²²

Genes related to ritter's disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	AGR3	anterior gradient 3 homolog (Xenopus laevis)	11.0	Disorders
2	SUMF2	sulfatase modifying factor 2	11.0	Disorders
3	HSF4	heat shock transcription factor 4	11.0
4	GML	glycosylphosphatidylinositol anchored molecule like protein	11.0	Disorders
5	DSG4	desmoglein 4	11.0
6	IBSP	integrin-binding sialoprotein	11.0
7	DSG3	desmoglein 3	11.0
8	DSG1	desmoglein 1	11.0
9	EDNRB	endothelin receptor type B	11.0
10	EDNRA	endothelin receptor type A	11.0

Compounds related to ritter's disease according to GeneDecks:

(show all 22)

id	Compound	Score	Top Affiliating Genes
1	pd 14506532	9.5	EDNRB, EDNRA
2	sitaxsentan32	9.5	EDNRB, EDNRA
3	ambrisentan32	9.5	EDNRB, EDNRA
4	pd 14289332	9.5	EDNRB, EDNRA
5	bq61032	9.4	EDNRB, EDNRA
6	bq 302032	9.4	EDNRB, EDNRA
7	irl 162032	9.4	EDNRA, EDNRB
8	tezosentan32	9.4	EDNRA, EDNRB
9	Sitaxentan9 9	10.4	EDNRA, EDNRB
10	fr13931732	9.4	EDNRB, EDNRA
11	sarafotoxin32	9.4	EDNRB, EDNRA
12	atrasentan32	9.4	EDNRB, EDNRA
13	darusentan32	9.3	EDNRB, EDNRA
14	bq78832	9.3	EDNRB, EDNRA
15	bq12332	9.2	EDNRA, EDNRB
16	bosentan32 9 9	11.2	EDNRB, EDNRA
17	sulfonamide32	9.0	EDNRA, EDNRB
18	phosphoramidon32 9 9	10.8	EDNRB, EDNRA
19	agarose32	8.7	IBSP, EDNRA, EDNRB
20	toxin a32	8.3	EDNRA, EDNRB, DSG1, DSG3
21	acetylcholine32 9 18 9	11.1	EDNRA, EDNRB, DSG1, DSG3
22	calcium32 9 18 9	10.1	IBSP, EDNRA, EDNRB, DSG1, DSG3, DSG4

Cellular components related to ritter's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	desmosome	GO:030057	8.9	DSG1, DSG3, DSG4

Biological processes related to ritter's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular component disassembly involved in apoptotic process	GO:006921	9.3	DSG1, DSG3
2	endothelin receptor signaling pathway	GO:086100	9.1	EDNRA, EDNRB
3	vasoconstriction	GO:042310	9.0	EDNRA, EDNRB
4	homophilic cell adhesion	GO:007156	8.6	DSG1, DSG3, DSG4

Molecular functions related to ritter's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endothelin receptor activity	GO:004962	9.1	EDNRA, EDNRB