SSSS
MCID: RTT001
MIFTS: 45

Ritter's Disease (SSSS) malady

Skin diseases, Infectious diseases categories

Summaries for Ritter's Disease

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus staphylococcus (s. aureus). the infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards: Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to exfoliation syndrome and pemphigus, and has symptoms including fluid-filled blister formation, fever and irritability. An important gene associated with Ritter's Disease is HSF4 (heat shock transcription factor 4), and among its related pathways are Endothelins and Endothelin. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Ritter's Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
staphylococcal scalded skin syndrome:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

ritter's disease 8
staphylococcal scalded skin syndrome 8 44 48 60
pemphigus neonatorum 8 60
toxic epidermal necrolysis, subcorneal type 8
dermatitis exfoliativa neonatorum 8
generalized exfoliative disease 48
scalded skin syndrome 8
sick sinus syndrome 60
ritters disease 10
ssss 48


External Ids:

Disease Ontology8 DOID:9063
MeSH34 D013206
NCIt39 C85077
ICD9CM27 695.81
SNOMED-CT via Orphanet57 200946001
ICD10 via Orphanet26 L00
ICD1025 L00

Related Diseases for Ritter's Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to ritter's disease

Clinical Features for Ritter's Disease

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Sources:
8Disease Ontology
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Symptoms:

8
  • fluid-filled blister formation
  • fever
  • irritability

Drugs & Therapeutics for Ritter's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ritter's Disease

Drug clinical trials:

Search ClinicalTrials for Ritter's Disease

Search NIH Clinical Center for Ritter's Disease

Search CenterWatch for Ritter's Disease

Genetic Tests for Ritter's Disease

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Anatomical Context for Ritter's Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Ritter's Disease:

32
Skin

Animal Models for Ritter's Disease or affiliated genes

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Publications for Ritter's Disease

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50PubMed
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Articles related to Ritter's Disease:

(show all 28)
idTitleAuthorsYear
1
Picture of the month. Ritter's disease (neonatal staphylococcal scalded skin syndrome). (1558075)
1992
2
Nosocomial scalded skin syndrome. Ritter's disease caused by phage group 3 Staphylococcus aureus. (6449146)
1980
3
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. (147160)
1978
4
Toxic epidermal necrolysis (TEN; Ritter's disease) and staphylococcal scalded skin syndrome (SSSS). A description and review. (780034)
1976
5
Total and specific IgE levels as a means of differentiating Ritter's disease from atopic dermatitis. (127536)
1975
6
New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease. (4139120)
1974
7
Epidemic boric acid poisoning simulating staphylococcal toxic epidermal necrolysis of the newborn infant: Ritter's disease. (4251286)
1970
8
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
9
Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. (4222069)
1966
10
RITTER'S DISEASE. (14291657)
1965
11
Epidemic staphylococcal pyoderma associated with Ritter's disease and the appearance of phage type 3B/71. (13975789)
1963
12
An outbreak of exfoliative dermatitis of the newborn (Ritter's disease) due to Staphylococcus aureus, phage-type 55/71. (13867356)
1962
13
Ritter's disease: exfoliative dermatitis of the newborn. (13869919)
1962
14
An outbreak of Ritter's disease. (13763310)
1961
15
Some interesting but rare disorders seen in pediatric practice with case report of Ritter's disease with recovery. (13502281)
1958
16
Ritter's disease (dermatitis exfoliativa neonatorum) with recovery. (13464996)
1957
17
Dermatitis exfoliativa neonatorum; Ritter's disease. (13468377)
1957
18
Ritter's disease with recovery. (13166184)
1954
19
Impetigo and acute infectious exfoliative dermatitis of the newborn infant (Ritter's disease). (14955740)
1952
20
Ritter's disease and sclerema; report on two rare cases in infants. (14921951)
1952
21
Ritter's disease. (18120097)
1949
22
Ritter's disease. (18920581)
1948
23
Ritter's disease; report of a case treated with vitamins and penicillin with recovery. (18101843)
1948
24
Topical and parenteral penicillin therapy in Ritter's disease; report of four cases with recovery. (18101064)
1948
25
Ritter's disease in fraternal twins, with special reference to the pathogenesis. (20255863)
1947
26
Ritter's disease (dermatitis exfoliativa neonatorum); report of a case. (20275913)
1946
27
A case of exfoliative dermatitis of the newborn (Ritter's disease). (21032230)
1942
28
A CASE OF RITTER'S DISEASE. (20770997)
1923

Genetic Variations for Ritter's Disease

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Expression for genes affiliated with Ritter's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ritter's Disease

Search GEO for disease gene expression data for Ritter's Disease.

Pathways for genes affiliated with Ritter's Disease

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Sources:
37NCBI BioSystems Database, 53Reactome
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Pathways related to Ritter's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EDNRA, EDNRB
29.6EDNRB, EDNRA
39.6EDNRA, EDNRB
4
Hide members
9.6DSG1, DSG3
59.6DSG1, DSG3

Compounds for genes affiliated with Ritter's Disease

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Ritter's Disease according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1[125i]et-12810.0EDNRA, EDNRB
2pd 1450654410.0EDNRB, EDNRA
3sitaxsentan44 2811.0EDNRB, EDNRA
4pd 142893449.9EDNRB, EDNRA
5bq610449.9EDNRB, EDNRA
6bq 302044 2810.9EDNRB, EDNRA
7ambrisentan44 2810.9EDNRB, EDNRA
8irl 162044 2810.9EDNRA, EDNRB
9tezosentan449.9EDNRA, EDNRB
10Sitaxentan119.9EDNRA, EDNRB
11fr13931744 2810.9EDNRB, EDNRA
12darusentan44 2810.9EDNRA, EDNRB
13atrasentan449.9EDNRA, EDNRB
14sarafotoxin449.8EDNRA, EDNRB
15bq78844 2810.8EDNRA, EDNRB
16bq12344 2810.8EDNRA, EDNRB
17bosentan44 1110.7EDNRA, EDNRB
18sulfonamide449.5EDNRB, EDNRA
19agarose449.3IBSP, EDNRB, EDNRA
20phosphoramidon44 1110.3EDNRA, EDNRB
21toxin a449.1DSG1, DSG3, EDNRA, EDNRB
22acetylcholine44 49 28 11 2412.9EDNRB, EDNRA, DSG3, DSG1
23serine448.4DSG1, DSG3, EDNRA, EDNRB, IBSP
24calcium44 49 11 2411.0DSG1, DSG3, DSG4, EDNRA, EDNRB, IBSP

GO Terms for genes affiliated with Ritter's Disease

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Sources:
16Gene Ontology
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Cellular components related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.3DSG1, DSG3, DSG4

Biological processes related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.7EDNRA, EDNRB
2vasoconstrictionGO:0423109.6EDNRB, EDNRA
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.6DSG1, DSG3
4enteric nervous system developmentGO:0484849.5EDNRA, EDNRB
5homophilic cell adhesionGO:0071569.3DSG1, DSG3, DSG4
6sensory perception of painGO:0192339.3EDNRA, EDNRB

Molecular functions related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.6EDNRA, EDNRB

Products for genes affiliated with Ritter's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ritter's Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet