MCID: RTT001
MIFTS: 40

Ritter's Disease

Categories: Skin diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Ritter's Disease

MalaCards integrated aliases for Ritter's Disease:

Name: Ritter's Disease 12 14
Staphylococcal Scalded Skin Syndrome 12 72 55 51 41 69
Pemphigus Neonatorum 12 69
Toxic Epidermal Necrolysis, Subcorneal Type 12
Dermatitis Exfoliativa Neonatorum 12
Generalized Exfoliative Disease 55
Scalded Skin Syndrome 12
Ritter Disease 12
Ssss 55

Characteristics:

Orphanet epidemiological data:

55
staphylococcal scalded skin syndrome
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9063
ICD10 32 L00
ICD9CM 34 695.81
MeSH 41 D013206
NCIt 46 C85077
Orphanet 55 ORPHA36236
MESH via Orphanet 42 D013206
UMLS via Orphanet 70 C0038165
ICD10 via Orphanet 33 L00

Summaries for Ritter's Disease

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards based summary : Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to pemphigus foliaceus and bullous impetigo, and has symptoms including fluid-filled blister formation, fever and irritability. An important gene associated with Ritter's Disease is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Keratinization and Apoptotic cleavage of cellular proteins. The drugs methicillin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related phenotypes are integument and vision/eye

Wikipedia : 72 Staphylococcal scalded skin syndrome, (SSSS), also known as Pemphigus neonatorum or Ritter\'s disease,... more...

Related Diseases for Ritter's Disease

Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to Ritter's Disease

Symptoms & Phenotypes for Ritter's Disease

Symptoms:

12
  • fluid-filled blister formation
  • fever
  • irritability

MGI Mouse Phenotypes related to Ritter's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 DSG1 DSG4 EDNRA EDNRB
2 vision/eye MP:0005391 8.92 DSG1 EDNRA EDNRB HSF4

Drugs & Therapeutics for Ritter's Disease

Drugs for Ritter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 methicillin
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276

Search NIH Clinical Center for Ritter's Disease

Cochrane evidence based reviews: staphylococcal scalded skin syndrome

Genetic Tests for Ritter's Disease

Anatomical Context for Ritter's Disease

MalaCards organs/tissues related to Ritter's Disease:

38
Skin, Colon

Publications for Ritter's Disease

Articles related to Ritter's Disease:

(show all 28)
# Title Authors Year
1
Picture of the month. Ritter's disease (neonatal staphylococcal scalded skin syndrome). ( 1558075 )
1992
2
Nosocomial scalded skin syndrome. Ritter's disease caused by phage group 3 Staphylococcus aureus. ( 6449146 )
1980
3
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. ( 147160 )
1978
4
Toxic epidermal necrolysis (TEN; Ritter's disease) and staphylococcal scalded skin syndrome (SSSS). A description and review. ( 780034 )
1976
5
Total and specific IgE levels as a means of differentiating Ritter's disease from atopic dermatitis. ( 127536 )
1975
6
New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease. ( 4139120 )
1974
7
Epidemic boric acid poisoning simulating staphylococcal toxic epidermal necrolysis of the newborn infant: Ritter's disease. ( 4251286 )
1970
8
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. ( 4252396 )
1969
9
Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. ( 4222069 )
1966
10
RITTER'S DISEASE. ( 14291657 )
1965
11
Epidemic staphylococcal pyoderma associated with Ritter's disease and the appearance of phage type 3B/71. ( 13975789 )
1963
12
Ritter's disease: exfoliative dermatitis of the newborn. ( 13869919 )
1962
13
An outbreak of exfoliative dermatitis of the newborn (Ritter's disease) due to Staphylococcus aureus, phage-type 55/71. ( 13867356 )
1962
14
An outbreak of Ritter's disease. ( 13763310 )
1961
15
Some interesting but rare disorders seen in pediatric practice with case report of Ritter's disease with recovery. ( 13502281 )
1958
16
Dermatitis exfoliativa neonatorum; Ritter's disease. ( 13468377 )
1957
17
Ritter's disease (dermatitis exfoliativa neonatorum) with recovery. ( 13464996 )
1957
18
Ritter's disease with recovery. ( 13166184 )
1954
19
Ritter's disease and sclerema; report on two rare cases in infants. ( 14921951 )
1952
20
Impetigo and acute infectious exfoliative dermatitis of the newborn infant (Ritter's disease). ( 14955740 )
1952
21
Ritter's disease. ( 18120097 )
1949
22
Ritter's disease; report of a case treated with vitamins and penicillin with recovery. ( 18101843 )
1948
23
Topical and parenteral penicillin therapy in Ritter's disease; report of four cases with recovery. ( 18101064 )
1948
24
Ritter's disease. ( 18920581 )
1948
25
Ritter's disease in fraternal twins, with special reference to the pathogenesis. ( 20255863 )
1947
26
Ritter's disease (dermatitis exfoliativa neonatorum); report of a case. ( 20275913 )
1946
27
A case of exfoliative dermatitis of the newborn (Ritter's disease). ( 21032230 )
1942
28
A CASE OF RITTER'S DISEASE. ( 20770997 )
1923

Variations for Ritter's Disease

Expression for Ritter's Disease

Search GEO for disease gene expression data for Ritter's Disease.

Pathways for Ritter's Disease

Pathways related to Ritter's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 DSG1 DSG2 DSG4
2
Show member pathways
11.39 DSG1 DSG2
3 10.98 EDNRA EDNRB
4 10.49 EDNRA EDNRB
5 10.1 EDNRA EDNRB

GO Terms for Ritter's Disease

Cellular components related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.16 DSG1 DSG2
2 cornified envelope GO:0001533 9.13 DSG1 DSG2 DSG4
3 desmosome GO:0030057 8.8 DSG1 DSG2 DSG4

Biological processes related to Ritter's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.65 DSG1 DSG2 DSG4
2 keratinization GO:0031424 9.54 DSG1 DSG2 DSG4
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.51 EDNRA EDNRB
4 cell-cell adhesion GO:0098609 9.49 DSG1 DSG4
5 regulation of blood pressure GO:0008217 9.46 EDNRA EDNRB
6 response to progesterone GO:0032570 9.43 DSG1 DSG2
7 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.43 DSG1 DSG2 DSG4
8 maternal process involved in female pregnancy GO:0060135 9.4 DSG1 DSG2
9 vasoconstriction GO:0042310 9.32 EDNRA EDNRB
10 enteric nervous system development GO:0048484 9.16 EDNRA EDNRB
11 cornification GO:0070268 9.13 DSG1 DSG2 DSG4
12 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.13 DSG1 DSG2 DSG4
2 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Ritter's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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