SSSS
MCID: RTT001
MIFTS: 40

Ritter's Disease (SSSS) malady

Skin, Infectious categories

Summaries for Ritter's Disease

Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus staphylococcus (s. aureus). the infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards: Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to bullous impetigo and pemphigus foliaceus, and has symptoms including fluid-filled blister formation, fever and irritability. An important gene associated with Ritter's Disease is HSF4 (heat shock transcription factor 4), and among its related pathways are Endothelins and Endothelin. The compounds [125i]et-1 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Ritter's Disease

Sources:
8Disease Ontology, 61UMLS, 45Novoseek, 49Orphanet, 10DISEASES, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
staphylococcal scalded skin syndrome:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

ritter's disease 8
staphylococcal scalded skin syndrome 8 45 49 61
pemphigus neonatorum 8 61
toxic epidermal necrolysis, subcorneal type 8
dermatitis exfoliativa neonatorum 8
generalized exfoliative disease 49
scalded skin syndrome 8
sick sinus syndrome 61
ritters disease 10
ssss 49


External Ids:

Disease Ontology8 DOID:9063
MeSH35 D013206
NCIt40 C85077
ICD9CM27 695.81
ICD10 via Orphanet26 L00
ICD1025 L00

Related Diseases for Ritter's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to ritter's disease

Clinical Features for Ritter's Disease

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • fluid-filled blister formation
  • fever
  • irritability

Drugs & Therapeutics for Ritter's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ritter's Disease

Drug clinical trials:

Search ClinicalTrials for Ritter's Disease

Search NIH Clinical Center for Ritter's Disease

Search CenterWatch for Ritter's Disease

Genetic Tests for Ritter's Disease

Anatomical Context for Ritter's Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Ritter's Disease:

33
Skin

Animal Models for Ritter's Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Ritter's Disease

Sources:
51PubMed
See all sources

Articles related to Ritter's Disease:

(show all 13)
idTitleAuthorsYear
1
Picture of the month. Ritter's disease (neonatal staphylococcal scalded skin syndrome). (1558075)
1992
2
Nosocomial scalded skin syndrome. Ritter's disease caused by phage group 3 Staphylococcus aureus. (6449146)
1980
3
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. (147160)
1978
4
Toxic epidermal necrolysis (TEN; Ritter's disease) and staphylococcal scalded skin syndrome (SSSS). A description and review. (780034)
1976
5
Total and specific IgE levels as a means of differentiating Ritter's disease from atopic dermatitis. (127536)
1975
6
New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease. (4139120)
1974
7
Epidemic boric acid poisoning simulating staphylococcal toxic epidermal necrolysis of the newborn infant: Ritter's disease. (4251286)
1970
8
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
9
Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. (4222069)
1966
10
Epidemic staphylococcal pyoderma associated with Ritter's disease and the appearance of phage type 3B/71. (13975789)
1963
11
An outbreak of exfoliative dermatitis of the newborn (Ritter's disease) due to Staphylococcus aureus, phage-type 55/71. (13867356)
1962
12
Ritter's disease and sclerema; report on two rare cases in infants. (14921951)
1952
13
Ritter's disease in fraternal twins, with special reference to the pathogenesis. (20255863)
1947

Genetic Variations for Ritter's Disease

Expression for genes affiliated with Ritter's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ritter's Disease

Search GEO for disease gene expression data for Ritter's Disease.

Pathways for genes affiliated with Ritter's Disease

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Ritter's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EDNRA, EDNRB
29.6EDNRB, EDNRA
39.6EDNRA, EDNRB
4
Hide members
9.6DSG1, DSG3
59.6DSG1, DSG3

Compounds for genes affiliated with Ritter's Disease

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Ritter's Disease according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1[125i]et-12910.0EDNRA, EDNRB
2pd 1450654510.0EDNRB, EDNRA
3sitaxsentan45 2911.0EDNRB, EDNRA
4pd 142893459.9EDNRB, EDNRA
5bq610459.9EDNRB, EDNRA
6bq 302045 2910.9EDNRB, EDNRA
7ambrisentan45 2910.9EDNRB, EDNRA
8irl 162045 2910.9EDNRA, EDNRB
9tezosentan459.9EDNRA, EDNRB
10Sitaxentan119.9EDNRA, EDNRB
11fr13931745 2910.9EDNRB, EDNRA
12darusentan45 2910.9EDNRA, EDNRB
13atrasentan459.9EDNRA, EDNRB
14sarafotoxin459.8EDNRA, EDNRB
15bq78845 2910.8EDNRA, EDNRB
16bq12345 2910.8EDNRA, EDNRB
17bosentan45 1110.7EDNRA, EDNRB
18sulfonamide459.5EDNRB, EDNRA
19agarose459.3IBSP, EDNRB, EDNRA
20phosphoramidon45 1110.3EDNRA, EDNRB
21toxin a459.1DSG1, DSG3, EDNRA, EDNRB
22acetylcholine45 50 29 11 2412.9EDNRB, EDNRA, DSG3, DSG1
23serine458.4DSG1, DSG3, EDNRA, EDNRB, IBSP
24calcium45 50 11 2411.0DSG1, DSG3, DSG4, EDNRA, EDNRB, IBSP

GO Terms for genes affiliated with Ritter's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300579.3DSG1, DSG3, DSG4

Biological processes related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epithelial cell proliferationGO:0506789.7EDNRA, EDNRB
2vasoconstrictionGO:0423109.6EDNRB, EDNRA
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.6DSG1, DSG3
4enteric nervous system developmentGO:0484849.5EDNRA, EDNRB
5homophilic cell adhesionGO:0071569.3DSG1, DSG3, DSG4
6sensory perception of painGO:0192339.3EDNRA, EDNRB

Molecular functions related to Ritter's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endothelin receptor activityGO:0049629.6EDNRA, EDNRB

Products for genes affiliated with Ritter's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ritter's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet