MCID: RTC003
MIFTS: 36

Root Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

MalaCards integrated aliases for Root Caries:

Name: Root Caries 12 52 42 14 69
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 35 521.08
MeSH 42 D017213
SNOMED-CT 64 234975001 30512007
ICD10 33 K02.2
UMLS 69 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to bullous retinoschisis and laron dwarfism. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Dopamine and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are liver/biliary system and neoplasm

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 bullous retinoschisis 10.5 CD79A DSPP
2 laron dwarfism 10.4 DSPP LTF
3 sialadenitis 10.4 CD79A LTF
4 asymptomatic dengue 10.4 CD79A LTF
5 diaphragmatic eventration 10.4 DSPP GPI
6 lip carcinoma in situ 10.4 CD79A LTF
7 atopic dermatitis 5 10.4 ALB CD79A
8 microinvasive cervical squamous cell carcinoma 10.4 ALB CD79A
9 ovary transitional cell carcinoma 10.4 ALB CD79A
10 non-congenital cyst of kidney 10.4 ALB CD79A
11 male genital organ stricture 10.4 ALB CD79A
12 adie pupil 10.4 ALB CD79A
13 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.4 ALB CD79A
14 immune-complex glomerulonephritis 10.4 ALB CD79A
15 tarp syndrome 10.4 ALB CD79A
16 adrenal gland disease 10.4 ALB CD79A
17 acute gonococcal cervicitis 10.4 ALB CD79A
18 entropion 10.3 CD79A LTF
19 dermatomycosis 10.3 ALB CD79A
20 pyrimidine metabolic disorder 10.3 ALB CD79A
21 toxic myocarditis 10.3 ALB CD79A
22 bladder diverticulum 10.3 ALB CD79A
23 autoimmune disease of cardiovascular system 10.3 ALB CD79A
24 spastic monoplegia 10.3 ALB CD79A
25 spastic entropion 10.3 ALB CD79A
26 bladder sarcoma 10.3 ALB CD79A
27 germ cell and embryonal cancer 10.3 CD79A LTF
28 aleutian mink disease 10.3 ALB CD79A
29 late yaws 10.3 ALB CD79A
30 choreatic disease 10.3 ALB CD79A
31 carcinoma arising in nasal papillomatosis 10.3 ALB CD79A
32 paranasal sinus sarcoma 10.2 ALB CD79A
33 opportunistic bacterial infectious disease 10.2 ALB CD79A
34 chronic endophthalmitis 10.2 ALB LTF
35 prostate neuroendocrine neoplasm 10.2 ALB CD79A
36 periodontitis 10.2
37 nasopharyngeal carcinoma 2 10.2 ALB CD79A
38 endometrial clear cell adenocarcinoma 10.2 ALB CD79A
39 lymphoma 10.2 ALB CD79A
40 uterus interstitial leiomyoma 10.2 ALB CD79A
41 nasal cavity carcinoma in situ 10.1 ALB CD79A
42 exocrine pancreatic insufficiency 10.1 ALB CD79A
43 vaginitis 10.1 CD79A DSPP LTF
44 premature ovarian failure 12 10.1 ALB CD79A
45 acute chest syndrome 10.0 ALB CD79A
46 calcinosis 10.0 ALB CD79A
47 mikulicz disease 9.9 ALB CD79A LTF
48 tuberculum sellae meningioma 9.9 ALB CD79A LTF
49 acral lentiginous melanoma 9.9 ALB CD79A
50 fg syndrome 5 9.9 ALB CD79A

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

MGI Mouse Phenotypes related to Root Caries:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.55 ALB CD79A GPI LTF SMARCA4
2 neoplasm MP:0002006 9.35 ALB CD79A LTF SMARCA2 SMARCA4
3 renal/urinary system MP:0005367 8.92 ALB CD79A SMARCA2 SMARCA4

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
3 Adrenergic Agents Phase 4
4 Cariostatic Agents Phase 4,Phase 2,Phase 3,Phase 1
5 Fluorides Phase 4,Phase 2,Phase 3,Phase 1
6 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
7 Autonomic Agents Phase 4
8 Central Nervous System Stimulants Phase 4
9 Dopamine Agents Phase 4
10 Dopamine Uptake Inhibitors Phase 4
11 Neurotransmitter Agents Phase 4
12 Neurotransmitter Uptake Inhibitors Phase 4
13 Peripheral Nervous System Agents Phase 4
14
Iodine Investigational Phase 2, Phase 3,Phase 1 7553-56-2 807
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Bone Density Conservation Agents Phase 2, Phase 3
17 Calcium, Dietary Phase 2, Phase 3
18
Bismuth Phase 2, Phase 3 7440-69-9 16682734 105143
19 Hemostatics Phase 2
20 Anti-Infective Agents Phase 1
21 Anti-Infective Agents, Local Phase 1
22 cadexomer iodine Phase 1
23 Micronutrients Phase 1
24 Trace Elements Phase 1
25
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
26
Salicylic acid Approved, Vet_approved 69-72-7 338
27
Zinc Approved 7440-66-6 32051 23994
28
Zinc oxide Approved 1314-13-2
29 Licorice Approved, Nutraceutical
30
Methylene blue Investigational 61-73-4
31 Adrenergic Agonists
32 Anesthetics
33 Antifungal Agents
34 Central Nervous System Depressants
35 Dermatologic Agents
36 Keratolytic Agents
37 Anesthetics, Local
38 Anti-Bacterial Agents
39 Photosensitizing Agents
40 Coagulants
41 Acidophilus Nutraceutical
42 Citrate Nutraceutical
43
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
2 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
3 Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas Completed NCT02742142 Phase 2, Phase 3 silver diammine fluoride
4 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed NCT02360124 Phase 2, Phase 3 silver diammine fluoride
5 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
6 Xylitol Adult Caries Trial (X-ACT) Completed NCT00393055 Phase 3
7 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth Completed NCT02492841 Phase 2, Phase 3 Mineral trioxide aggregate;Calcium hydroxide;Biodentine
8 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
9 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed NCT02019563 Phase 2
10 Use of Radiographic Contrast to Detect Dental Caries Completed NCT01523509 Phase 1
11 Non-invasive Treatment of Root Caries in Older Adults Active, not recruiting NCT02647203 Phase 1 Self-administered fluoridated dentifrices
12 Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers Unknown status NCT01147835
13 Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF Completed NCT01738958
14 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Completed NCT03119779 MTA-Anglus;TheraCal
15 The CAP-1 Trial: Stepwise Excavation Versus One Completed Excavation in Deep Caries Completed NCT00187837
16 Radiographic Contrast To Differentiate Cavitated From Non-cavitated Tooth Decay Completed NCT02359279
17 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565
18 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
19 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280
20 Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal Recruiting NCT03186352
21 Intraoral Imaging at Clinical Crown Lengthening Recruiting NCT03064217
22 Clinical Comparison of Vital Pulp Capping Restorative Protocols Recruiting NCT02635867 Resin-modified calcium silicate - TheraCal LC;Calcium hydroxide - Dycal;Resin-based dentin bonding agent
23 Pulpotomy vs Pulpectomy Outcome. Recruiting NCT02727088
24 Treatment of Root Caries in an Older Irish Population. Active, not recruiting NCT01866059
25 Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers Active, not recruiting NCT03185104 Silver Diamine Fluoride;Distilled Water
26 Evaluation of Antimicrobial Photodynamic Therapy for the Treatment of Deep Carious Lesions in Children: an in Vivo Study Active, not recruiting NCT02908789
27 Electrical and Formocresol Pulpotomy in Primary Molars Terminated NCT01622153

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

39
Bone

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 322)
id Title Authors Year
1
Four-year incidence rate and predictors of root caries among community-dwelling south Brazilian older adults. ( 28921685 )
2017
2
Cost-effectiveness of root caries preventive treatments. ( 27984089 )
2017
3
Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil. ( 28492755 )
2017
4
Status and progress of treatment methods for root caries in the last decade: a literature review. ( 28833210 )
2017
5
Root caries analysis in working population of 35-44 years of age (Spain). ( 28809367 )
2017
6
State-of-the-art cosmetic restorative treatment for combating root caries. ( 28475077 )
2017
7
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
8
Evaluation of the Cariogram for root caries prediction. ( 28456556 )
2017
9
Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen. ( 28183611 )
2017
10
Root caries experience among Australian adults. ( 28488339 )
2017
11
Randomized clinical trial on arresting dental root caries through silver diamine fluoride applications in community-dwelling elders. ( 27713457 )
2016
12
Actinomyces spp. gene expression in root caries lesions. ( 27640531 )
2016
13
Ecological Hypothesis of Dentin and Root Caries. ( 27458979 )
2016
14
Risk indicators associated with root caries in independently living older adults. ( 27208875 )
2016
15
INVESTIGATING THE ADDITION OF COLLAGEN AND ITS INTEGRIN BINDING SEQUENCE (RGD) TO GLASS POLYALKENOATE; IN TERMS OF MATERIAL AND CELLULAR PROPERTIES TO EXPLORE A MORE BIOCOMPATIBLE METHOD OF ROOT CARIES RESTORATION. ( 27662793 )
2016
16
Prevalence of root caries among elders living in residential homes of Bengaluru city, India. ( 27398175 )
2016
17
Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. ( 27208876 )
2016
18
Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly. ( 27957565 )
2016
19
Ecological hypothesis of dentin and root caries. ( 27713451 )
2016
20
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. ( 26687774 )
2016
21
A Predictive Model for Root Caries Incidence. ( 27160516 )
2016
22
Activity assessment of root caries lesions with thermal and near-IR imaging methods. ( 27060450 )
2016
23
Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders. ( 27253146 )
2016
24
Root caries: Risk indicators associated with root caries in independently living older adults. ( 27608575 )
2016
25
Effect of over-the-counter fluoridated products regimens on root caries inhibition. ( 26299400 )
2015
26
Root Caries in Older Adults. ( 26357814 )
2015
27
The Dietary Approaches to Stop Hypertension Diet and New and Recurrent Root Caries Events in Men. ( 26280256 )
2015
28
Topical agents for root caries prevention. ( 25909930 )
2015
29
Effect of flavonoids on remineralization of artificial root caries. ( 26296390 )
2015
30
Root Caries: Causes, Prevention, and Treatment. ( 26775536 )
2015
31
Response to Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078425 )
2015
32
Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078422 )
2015
33
Development of a multifunctional adhesive system for prevention of root caries and secondary caries. ( 26187532 )
2015
34
Extensive description and comparison of human supra-gingival microbiome in root caries and health. ( 25658087 )
2015
35
Some beneficial effect on root caries from use of higher concentration fluoride toothpaste (5000 ppm F). ( 24763166 )
2014
36
Root caries, root surface restorations and lifestyle factors in adult Danes. ( 25467782 )
2014
37
Systematic Review on Noninvasive Treatment of Root Caries Lesions. ( 25398366 )
2014
38
Cohort study on incidence of coronal and root caries in Japanese adults. ( 25212557 )
2014
39
Synergistic effect of Proanthocyanidin and CPP-ACFP on remineralization of artificial root caries. ( 25363724 )
2014
40
Role of fluoridated dentifrices in root caries formation in vitro. ( 24902401 )
2014
41
Failure rates of class V restorations in the management of root caries in adults - a systematic review. ( 25395000 )
2014
42
Association of root caries with oral habits in older individuals attending a rural health centre of a dental hospital in India. ( 25584324 )
2014
43
Risk indicators for root caries in institutionalized elders. ( 24750310 )
2014
44
Root caries among type 2 diabetes mellitus patients visiting a hospital. ( 24612224 )
2014
45
Prevalence of root caries among ambulant older adults living in central Chile. ( 23802708 )
2013
46
Middle-aged (45 to 64 years) persons may have different factors associated with root caries than older adults (a8Y 65). ( 24237748 )
2013
47
Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. ( 23392087 )
2013
48
Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. ( 23985437 )
2013
49
Root caries: a periodontal perspective. ( 23647556 )
2013
50
Atraumatic restorative treatment and Carisolv use for root caries in the elderly: 2-year follow-up randomized clinical trial. ( 23974801 )
2013

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

Pathways related to Root Caries according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.16 SMARCA2 SMARCA4
2 humoral immune response GO:0006959 8.96 GPI LTF
3 retina homeostasis GO:0001895 8.62 ALB LTF

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA-dependent ATPase activity GO:0008094 9.16 SMARCA2 SMARCA4
2 RNA polymerase II transcription coactivator activity GO:0001105 8.96 SMARCA2 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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