MCID: RTC003
MIFTS: 38

Root Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

MalaCards integrated aliases for Root Caries:

Name: Root Caries 12 51 41 14 69
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 34 521.08
MeSH 41 D017213
SNOMED-CT 64 234975001 30512007
ICD10 32 K02.2
UMLS 69 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to gingivitis and dental caries. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Iodine and Cariostatic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 gingivitis 30.1 CD79A LTF
2 dental caries 29.6 CD79A DSPP LTF
3 aging 10.3
4 vaginal disease 10.3 CD79A DSPP
5 periodontitis 10.3
6 aplasia of lacrimal and salivary glands 10.3 DSPP LTF
7 acute diarrhea 10.3 CD79A LTF
8 dentin caries 10.3 DSPP GPI
9 chickenpox 10.2 CD79A LTF
10 cork-handlers' disease 10.2 ALB CD79A
11 ostertagiasis 10.2 ALB CD79A
12 dermatitis, atopic, 3 10.2 ALB CD79A
13 orthostatic proteinuria 10.2 ALB CD79A
14 marasmus 10.2 ALB CD79A
15 yellow nail syndrome 10.2 ALB CD79A
16 chronic graft versus host disease 10.2 ALB CD79A
17 diffuse glomerulonephritis 10.2 ALB CD79A
18 focal dermal hypoplasia 10.2 ALB CD79A
19 non-secretory myeloma 10.2 ALB CD79A
20 shigellosis 10.2 CD79A LTF
21 hypersensitivity reaction type iii disease 10.2 ALB CD79A
22 protein-losing enteropathy 10.2 ALB CD79A
23 ulcerative stomatitis 10.2 ALB CD79A
24 pneumocystosis 10.2 ALB CD79A
25 autoimmune disease of urogenital tract 10.2 ALB CD79A
26 lipoid nephrosis 10.2 ALB CD79A
27 protein-energy malnutrition 10.2 ALB CD79A
28 meningoencephalitis 10.2 ALB CD79A
29 membranoproliferative glomerulonephritis 10.2 ALB CD79A
30 glass syndrome 10.1
31 guillain-barre syndrome 10.1 ALB CD79A
32 extrinsic allergic alveolitis 10.1 ALB CD79A
33 obstructive jaundice 10.1 ALB CD79A
34 primary bacterial infectious disease 10.1 ALB CD79A
35 membranous nephropathy 10.1 ALB CD79A
36 mastitis 10.1 ALB LTF
37 intestinal disease 10.1 ALB CD79A
38 hypersensitivity reaction disease 10.1 ALB CD79A
39 schistosomiasis 10.1 ALB CD79A
40 bronchitis 10.1 ALB CD79A
41 end stage renal failure 10.0 ALB CD79A
42 otitis media 10.0 ALB CD79A
43 respiratory system disease 10.0 ALB CD79A
44 periodontal disease 10.0
45 urinary system disease 10.0 ALB CD79A
46 iga glomerulonephritis 9.9 ALB CD79A
47 diabetes mellitus 9.9
48 cervicitis 9.9
49 parotitis 9.9 ALB CD79A LTF
50 dysentery 9.9 ALB CD79A LTF

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

MGI Mouse Phenotypes related to Root Caries:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 CD79A GPI LTF SMARCA2 SMARCA4 ALB
2 liver/biliary system MP:0005370 9.55 ALB CD79A GPI LTF SMARCA4
3 neoplasm MP:0002006 9.35 ALB CD79A LTF SMARCA2 SMARCA4
4 renal/urinary system MP:0005367 8.92 ALB CD79A SMARCA2 SMARCA4

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 2, Phase 3 7553-56-2 807
2 Cariostatic Agents Phase 2, Phase 3, Phase 1
3 Fluorides Phase 2, Phase 3, Phase 1
4 Protective Agents Phase 2, Phase 3, Phase 1
5 Pharmaceutical Solutions Phase 2, Phase 3
6
Dopamine Approved 51-61-6, 62-31-7 681
7
Methamphetamine Approved, Illicit 537-46-2 10836
8 Anti-Bacterial Agents
9 Anti-Infective Agents
10 Photosensitizing Agents
11 Adrenergic Agents
12 Autonomic Agents
13 Bone Density Conservation Agents
14 Calcium, Dietary
15 Central Nervous System Stimulants
16 Dopamine Agents
17 Dopamine Uptake Inhibitors
18 Neurotransmitter Agents
19 Neurotransmitter Uptake Inhibitors
20 Peripheral Nervous System Agents
21 Acidophilus Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas Completed NCT02742142 Phase 2, Phase 3 silver diammine fluoride
2 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed NCT02360124 Phase 2, Phase 3 silver diammine fluoride
3 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
4 Silver Diamine Fluoride and Gingivitis in Geriatric Patients Not yet recruiting NCT03445286 Phase 2 Chlorhexidine
5 Non-invasive Treatment of Root Caries in Older Adults Unknown status NCT02647203 Phase 1 Self-administered fluoridated dentifrices
6 Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF Completed NCT01738958
7 Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal Recruiting NCT03186352
8 Intraoral Imaging at Clinical Crown Lengthening Recruiting NCT03064217
9 Treatment of Root Caries in an Older Irish Population. Active, not recruiting NCT01866059
10 Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers Active, not recruiting NCT03185104 Silver Diamine Fluoride;Distilled Water

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

38
Bone

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 333)
# Title Authors Year
1
Effect of Green Tea Varnish on Depth of Root Caries. ( 29422461 )
2018
2
A literature review and hypothesis for the etiologies of cervical and root caries. ( 29349909 )
2018
3
Root caries prevention via sodium fluoride, chlorhexidine and silver diamine fluoride in vitro. ( 29387999 )
2018
4
Contextual and Individual Determinants of Root Caries in Older People. ( 29393150 )
2018
5
Remineralization Potential of Mints Containing Bioactive Agents in Artificially Induced Root Caries. ( 29414808 )
2018
6
State-of-the-art cosmetic restorative treatment for combating root caries. ( 28475077 )
2017
7
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
8
Root caries analysis in working population of 35-44 years of age (Spain). ( 28809367 )
2017
9
Conventional Preventive Therapies (Fluoride) on Root Caries Lesions. ( 29050025 )
2017
10
Management of Cavitated Root Caries Lesions: Minimum Intervention and Alternatives. ( 29050028 )
2017
11
Evaluation of the Cariogram for root caries prediction. ( 28456556 )
2017
12
Monitoring of Root Caries Lesions. ( 29050023 )
2017
13
Cost-effectiveness of root caries preventive treatments. ( 27984089 )
2017
14
Assessment of Root Caries Lesion Activity and Its Histopathological Features. ( 29050022 )
2017
15
Root caries experience among Australian adults. ( 28488339 )
2017
16
Four-year incidence rate and predictors of root caries among community-dwelling south Brazilian older adults. ( 28921685 )
2017
17
Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil. ( 28492755 )
2017
18
Endogenous Enzymes in Root Caries. ( 29050019 )
2017
19
Status and progress of treatment methods for root caries in the last decade: a literature review. ( 28833210 )
2017
20
Incidence, Prevalence and Global Distribution of Root Caries. ( 29050015 )
2017
21
Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen. ( 28183611 )
2017
22
Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. ( 27208876 )
2016
23
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. ( 26687774 )
2016
24
A Predictive Model for Root Caries Incidence. ( 27160516 )
2016
25
Risk indicators associated with root caries in independently living older adults. ( 27208875 )
2016
26
Ecological Hypothesis of Dentin and Root Caries. ( 27458979 )
2016
27
Root caries: Risk indicators associated with root caries in independently living older adults. ( 27608575 )
2016
28
Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly. ( 27957565 )
2016
29
Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders. ( 27253146 )
2016
30
Randomized clinical trial on arresting dental root caries through silver diamine fluoride applications in community-dwelling elders. ( 27713457 )
2016
31
Prevalence of root caries among elders living in residential homes of Bengaluru city, India. ( 27398175 )
2016
32
INVESTIGATING THE ADDITION OF COLLAGEN AND ITS INTEGRIN BINDING SEQUENCE (RGD) TO GLASS POLYALKENOATE; IN TERMS OF MATERIAL AND CELLULAR PROPERTIES TO EXPLORE A MORE BIOCOMPATIBLE METHOD OF ROOT CARIES RESTORATION. ( 27662793 )
2016
33
Actinomyces spp. gene expression in root caries lesions. ( 27640531 )
2016
34
Activity assessment of root caries lesions with thermal and near-IR imaging methods. ( 27060450 )
2016
35
Ecological hypothesis of dentin and root caries. ( 27713451 )
2016
36
Response to Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078425 )
2015
37
Effect of over-the-counter fluoridated products regimens on root caries inhibition. ( 26299400 )
2015
38
Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078422 )
2015
39
Root Caries: Causes, Prevention, and Treatment. ( 26775536 )
2015
40
Development of a multifunctional adhesive system for prevention of root caries and secondary caries. ( 26187532 )
2015
41
Topical agents for root caries prevention. ( 25909930 )
2015
42
The Dietary Approaches to Stop Hypertension Diet and New and Recurrent Root Caries Events in Men. ( 26280256 )
2015
43
Effect of flavonoids on remineralization of artificial root caries. ( 26296390 )
2015
44
Extensive description and comparison of human supra-gingival microbiome in root caries and health. ( 25658087 )
2015
45
Root Caries in Older Adults. ( 26357814 )
2015
46
Some beneficial effect on root caries from use of higher concentration fluoride toothpaste (5000 ppm F). ( 24763166 )
2014
47
Risk indicators for root caries in institutionalized elders. ( 24750310 )
2014
48
Synergistic effect of Proanthocyanidin and CPP-ACFP on remineralization of artificial root caries. ( 25363724 )
2014
49
Cohort study on incidence of coronal and root caries in Japanese adults. ( 25212557 )
2014
50
Systematic Review on Noninvasive Treatment of Root Caries Lesions. ( 25398366 )
2014

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

Pathways related to Root Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 DSPP LTF
2 chromatin remodeling GO:0006338 9.26 SMARCA2 SMARCA4
3 humoral immune response GO:0006959 9.16 GPI LTF
4 retina homeostasis GO:0001895 8.96 ALB LTF
5 ATP-dependent chromatin remodeling GO:0043044 8.62 SMARCA2 SMARCA4

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription coactivator activity GO:0001105 9.16 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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