MCID: RTC003
MIFTS: 37

Root Caries malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

Aliases & Descriptions for Root Caries:

Name: Root Caries 12 52 42 14 69
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 35 521.08
MeSH 42 D017213
SNOMED-CT 64 234975001 30512007
ICD10 33 K02.2
UMLS 69 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to periodontitis and viral meningitis. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Dopamine and Methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 periodontitis 10.2
2 viral meningitis 10.2 CD79A LTF
3 growth hormone insensitivity, partial 10.2 DSPP LTF
4 diaphragm disease 10.2 DSPP GPI
5 adenoiditis 10.2 CD79A LTF
6 atopic dermatitis 6 10.2 ALB CD79A
7 colloid adenoma 10.2 ALB CD79A
8 schneiderian carcinoma 10.2 ALB CD79A
9 perinatal necrotizing enterocolitis 10.2 CD79A LTF
10 striatonigral degeneration 10.2 ALB CD79A
11 congenital nystagmus 10.2 ALB CD79A
12 male genital organ stricture 10.2 ALB CD79A
13 tarp syndrome 10.2 ALB CD79A
14 coronary artery dissection, spontaneous 10.2 ALB CD79A
15 acute cervicitis 10.1 ALB CD79A
16 ciliary discoordination, due to random ciliary orientation 10.1 ALB CD79A
17 angiokeratoma 10.1 ALB CD79A
18 venezuelan equine encephalitis 10.1 ALB CD79A
19 dermatomycosis 10.1 ALB CD79A
20 entropion 10.1 CD79A LTF
21 malignant hyperthermia susceptibility 1 10.1 ALB CD79A
22 hemiplegia 10.1 ALB CD79A
23 bronchiolitis 10.1 ALB CD79A
24 autonomic peripheral neuropathy 10.1 ALB CD79A
25 bladder sarcoma 10.1 ALB CD79A
26 early yaws 10.1 ALB CD79A
27 choreatic disease 10.1 ALB CD79A
28 stenosis of lacrimal sac 10.1 CD79A LTF
29 breast apocrine carcinoma in situ 10.1 ALB CD79A
30 paranasal sinus sarcoma 10.1 ALB CD79A
31 mixed germ cell-sex cord neoplasm 10.1 ALB CD79A
32 paragonimiasis 10.1 ALB LTF
33 anterior foramen magnum meningioma 10.1 ALB CD79A
34 vaginitis 10.0 CD79A DSPP LTF
35 uterine ligament serous adenocarcinoma 10.0 ALB CD79A
36 familial nephrotic syndrome 10.0 ALB CD79A
37 nephropathy with pretibial epidermolysis bullosa and deafness 10.0 ALB CD79A
38 mikulicz disease 10.0 ALB CD79A LTF
39 spastic entropion 10.0 ALB CD79A LTF
40 membranoproliferative glomerulonephritis 10.0 ALB CD79A LTF
41 childhood malignant hemangiopericytoma 10.0 ALB CD79A LTF
42 alzheimer's disease 13 10.0 SMARCA2 SMARCA4
43 cone dystrophy 4 10.0 SMARCA2 SMARCA4
44 familial renal papillary carcinoma 10.0 ALB CD79A
45 3p- syndrome 10.0 SMARCA2 SMARCA4
46 periodontal disease 9.9
47 muscular dystrophy, limb-girdle, type 1f 9.9 SMARCA2 SMARCA4
48 uterus interstitial leiomyoma 9.9 ALB CD79A
49 heinz body anemia 9.8 SMARCA2 SMARCA4
50 kluver-bucy syndrome 9.8 GPI SMARCA2 SMARCA4

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

MGI Mouse Phenotypes related to Root Caries:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ALB CD79A GPI LTF SMARCA2 SMARCA4
2 liver/biliary system MP:0005370 9.55 ALB CD79A GPI LTF SMARCA4
3 neoplasm MP:0002006 9.35 SMARCA2 SMARCA4 ALB CD79A LTF
4 renal/urinary system MP:0005367 8.92 ALB CD79A SMARCA2 SMARCA4

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
3 Adrenergic Agents Phase 4
4 Fluorides Phase 4,Phase 2,Phase 3,Phase 1
5 Neurotransmitter Agents Phase 4
6 Neurotransmitter Uptake Inhibitors Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Dopamine Agents Phase 4
9 Dopamine Uptake Inhibitors Phase 4
10 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Autonomic Agents Phase 4
12 Cariostatic Agents Phase 4,Phase 2,Phase 3,Phase 1
13 Central Nervous System Stimulants Phase 4
14
Chlorhexidine Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 55-56-1 9552079 2713
15 Bone Density Conservation Agents Phase 2, Phase 3
16 Calcium, Dietary Phase 2, Phase 3
17
Iodine Phase 2, Phase 3,Phase 1 7553-56-2 807
18
Bismuth Phase 2, Phase 3 7440-69-9 16682734 105143
19 Chlorhexidine gluconate Phase 3,Phase 2,Early Phase 1
20 Dermatologic Agents Phase 3
21 Disinfectants Phase 3
22 Pharmaceutical Solutions Phase 2, Phase 3, Early Phase 1
23 Anti-Bacterial Agents Phase 3
24 Anti-Infective Agents Phase 3,Phase 1
25 Anti-Infective Agents, Local Phase 3,Phase 1
26 Hemostatics Phase 2
27 Tea Nutraceutical Phase 2
28 cadexomer iodine Phase 1
29 Trace Elements Phase 1
30 Micronutrients Phase 1
31
Zinc Approved 7440-66-6 32051 23994
32
Salicylic acid Approved, Vet_approved 69-72-7 338
33
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
34
Zinc oxide Approved 1314-13-2
35
Menthol Approved Early Phase 1 2216-51-5 16666
36
Methylene blue Investigational 61-73-4
37 Adrenergic Agonists
38 Anesthetics
39 Anesthetics, Local
40 Antifungal Agents
41 Keratolytic Agents
42 Central Nervous System Depressants
43 Photosensitizing Agents
44 Coagulants
45 Licorice Nutraceutical
46 Citrate Nutraceutical
47
Citric Acid Nutraceutical, Vet_approved 77-92-9 311
48 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
2 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
3 Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas Completed NCT02742142 Phase 2, Phase 3
4 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed NCT02360124 Phase 2, Phase 3
5 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
6 Xylitol Adult Caries Trial (X-ACT) Completed NCT00393055 Phase 3
7 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3
8 "Clinical Trials to Enhance Elders' Oral Health" ("TEETH") Completed NCT00004640 Phase 3
9 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth Recruiting NCT02492841 Phase 2, Phase 3
10 Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts Recruiting NCT01461239 Phase 3
11 Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial Active, not recruiting NCT02216942 Phase 3
12 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2
13 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed NCT02019563 Phase 2
14 Evaluation of Synergistic Anti-plaque Activity of Salvadora Persica L. and Green Tea: A Clinical Comparative Study Completed NCT02624336 Phase 2
15 Use of Radiographic Contrast to Detect Dental Caries Completed NCT01523509 Phase 1
16 Non-invasive Treatment of Root Caries in Older Adults Active, not recruiting NCT02647203 Phase 1
17 Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers Unknown status NCT01147835
18 Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF Completed NCT01738958
19 The CAP-1 Trial: Stepwise Excavation Versus One Completed Excavation in Deep Caries Completed NCT00187837
20 Radiographic Contrast To Differentiate Cavitated From Non-cavitated Tooth Decay Completed NCT02359279
21 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565
22 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
23 Vital Pulp Therapy to Treat Irreversible Pulpitis Completed NCT00748280
24 Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments Completed NCT01427764
25 Clinical Comparison of Vital Pulp Capping Restorative Protocols Recruiting NCT02635867
26 Pulpotomy vs Pulpectomy Outcome. Recruiting NCT02727088
27 Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy Recruiting NCT02119455
28 The Oral Cavity as a Source of Febrile Neutropenia Recruiting NCT02702583
29 Treatment of Root Caries in an Older Irish Population. Active, not recruiting NCT01866059
30 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Active, not recruiting NCT03119779
31 Evaluation of Antimicrobial Photodynamic Therapy for the Treatment of Deep Carious Lesions in Children: an in Vivo Study Active, not recruiting NCT02908789
32 Oral Hygiene Intervention Pilot Study Active, not recruiting NCT02668809 Early Phase 1
33 Intraoral Imaging at Clinical Crown Lengthening Not yet recruiting NCT03064217
34 Evaluation of Survival of Mature Second Premolar Treated With Regenerative Techniques Not yet recruiting NCT02915419
35 Electrical and Formocresol Pulpotomy in Primary Molars Terminated NCT01622153

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

39
Bone

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 313)
id Title Authors Year
1
Cost-effectiveness of root caries preventive treatments. ( 27984089 )
2017
2
Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly. ( 27957565 )
2016
3
Risk indicators associated with root caries in independently living older adults. ( 27208875 )
2016
4
Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. ( 27208876 )
2016
5
Ecological hypothesis of dentin and root caries. ( 27713451 )
2016
6
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. ( 26687774 )
2016
7
Prevalence of root caries among elders living in residential homes of Bengaluru city, India. ( 27398175 )
2016
8
Actinomyces spp. gene expression in root caries lesions. ( 27640531 )
2016
9
Root caries: Risk indicators associated with root caries in independently living older adults. ( 27608575 )
2016
10
A Predictive Model for Root Caries Incidence. ( 27160516 )
2016
11
Activity assessment of root caries lesions with thermal and near-IR imaging methods. ( 27060450 )
2016
12
Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders. ( 27253146 )
2016
13
Randomized clinical trial on arresting dental root caries through silver diamine fluoride applications in community-dwelling elders. ( 27713457 )
2016
14
INVESTIGATING THE ADDITION OF COLLAGEN AND ITS INTEGRIN BINDING SEQUENCE (RGD) TO GLASS POLYALKENOATE; IN TERMS OF MATERIAL AND CELLULAR PROPERTIES TO EXPLORE A MORE BIOCOMPATIBLE METHOD OF ROOT CARIES RESTORATION. ( 27662793 )
2016
15
Ecological Hypothesis of Dentin and Root Caries. ( 27458979 )
2016
16
Root Caries in Older Adults. ( 26357814 )
2015
17
Extensive description and comparison of human supra-gingival microbiome in root caries and health. ( 25658087 )
2015
18
Effect of over-the-counter fluoridated products regimens on root caries inhibition. ( 26299400 )
2015
19
Root Caries: Causes, Prevention, and Treatment. ( 26775536 )
2015
20
Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078422 )
2015
21
Development of a multifunctional adhesive system for prevention of root caries and secondary caries. ( 26187532 )
2015
22
Response to Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078425 )
2015
23
Effect of flavonoids on remineralization of artificial root caries. ( 26296390 )
2015
24
The Dietary Approaches to Stop Hypertension Diet and New and Recurrent Root Caries Events in Men. ( 26280256 )
2015
25
Topical agents for root caries prevention. ( 25909930 )
2015
26
Cohort study on incidence of coronal and root caries in Japanese adults. ( 25212557 )
2014
27
Root caries among type 2 diabetes mellitus patients visiting a hospital. ( 24612224 )
2014
28
Systematic Review on Noninvasive Treatment of Root Caries Lesions. ( 25398366 )
2014
29
Root caries, root surface restorations and lifestyle factors in adult Danes. ( 25467782 )
2014
30
Failure rates of class V restorations in the management of root caries in adults - a systematic review. ( 25395000 )
2014
31
Synergistic effect of Proanthocyanidin and CPP-ACFP on remineralization of artificial root caries. ( 25363724 )
2014
32
Association of root caries with oral habits in older individuals attending a rural health centre of a dental hospital in India. ( 25584324 )
2014
33
Some beneficial effect on root caries from use of higher concentration fluoride toothpaste (5000 ppm F). ( 24763166 )
2014
34
Role of fluoridated dentifrices in root caries formation in vitro. ( 24902401 )
2014
35
Risk indicators for root caries in institutionalized elders. ( 24750310 )
2014
36
Prevalence of root caries among ambulant older adults living in central Chile. ( 23802708 )
2013
37
A randomized clinical trial of the anti-caries efficacy of 5,000 compared to 1,450 ppm fluoridated toothpaste on root caries lesions in elderly disabled nursing home residents. ( 23594784 )
2013
38
Use of chlorhexidine varnish to prevent root caries may benefit some patients. ( 23989843 )
2013
39
Fluoride dentifrice containing xylitol: in vitro root caries formation. ( 23724551 )
2013
40
Root caries: a survey of Queensland dentists. ( 23433394 )
2013
41
The role of fluoride in the preventive management of dentin hypersensitivity and root caries. ( 23271217 )
2013
42
The efficacy of fluoride on root caries progression may be dose-dependent. ( 24237745 )
2013
43
The use of bur and laser for root caries treatment: a comparative study. ( 23088186 )
2013
44
Atraumatic restorative treatment and Carisolv use for root caries in the elderly: 2-year follow-up randomized clinical trial. ( 23974801 )
2013
45
Middle-aged (45 to 64 years) persons may have different factors associated with root caries than older adults (a8Y 65). ( 24237748 )
2013
46
Prevention of root caries: a literature review of primary and secondary preventive agents. ( 23600985 )
2013
47
Preventing root caries development under oral biofilm challenge in an artificial mouth. ( 23524434 )
2013
48
Effect of CO(2) laser on root caries inhibition around composite restorations: an in vitro study. ( 23291879 )
2013
49
Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries. ( 23985437 )
2013
50
Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. ( 23392087 )
2013

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

Pathways related to Root Caries according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.16 SMARCA2 SMARCA4
2 humoral immune response GO:0006959 8.96 GPI LTF
3 retina homeostasis GO:0001895 8.62 ALB LTF

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription coactivator activity GO:0001105 9.16 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
3 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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