MCID: RTR008
MIFTS: 41

Root Resorption malady

Summaries for Root Resorption

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 In dentistry, root resorption is the breakdown or destruction, and subsequent loss, of the root... more...

MalaCards: Root Resorption is related to gingival recession and ankylosis. An important gene associated with Root Resorption is AMELY (amelogenin, Y-linked), and among its related pathways are BAFF in B-Cell Signaling and Osteoclast Signaling. The compounds benzalkonium chloride and fluorides have been mentioned in the context of this disorder. Affiliated tissues include thyroid and b cells, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Root Resorption

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH
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Aliases & Descriptions:

root resorption 8 10 61


External Ids:

Disease Ontology8 DOID:14550
MeSH35 D012391

Related Diseases for Root Resorption

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Root Resorption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1gingival recession30.1DSPP
2ankylosis30.1GDF7, GDF5, HEBP1
3dental pulp necrosis30.1AMELX, AMELY
4amelogenesis imperfecta30.1AMELY, AMELX, DSPP
5tooth resorption11.0
6atopic dermatitis10.2
7root caries10.2
8marfan syndrome10.1
9osteoblastoma10.1
10hereditary hemorrhagic telangiectasia10.1
11type vi ehlers-danlos syndrome10.1
12hypercementosis10.1
13cleft palate10.1
14adenomatoid tumor10.1
15fibrous dysplasia10.1
16adenoma10.1
17asthma10.1
18ehlers–danlos syndrome10.1
19ehlers-danlos syndrome, type vii10.1
20ehlers-danlos syndrome, type viii10.1
21ehlers-danlos syndrome, periodontitis type10.1
22periodontitis10.0IL1A
23turner syndrome10.0AMELX, AMELY
24dermatomyositis10.0IL1A
25hepatitis10.0CASP8
26dental fluorosis10.0AMELX, AMELY
27giant cell reparative granuloma10.0SH3BP2
28dental caries10.0DSPP
29multiple myeloma10.0TNFSF11
30osteomyelitis10.0TNFSF11, CTSK
31dentinogenesis imperfecta 110.0DSPP, DMP1
32chondrosarcoma10.0CTSK
33osteosclerosis10.0CTSK, TNFSF11
34dentinogenesis imperfecta10.0DMP1, DSPP
35polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11
36pulpitis10.0IL1A, DSPP
37hepatitis b10.0CASP8
38osteomalacia10.0DMP1, CALCA
39osteopetrosis10.0CTSK, TNFSF11, TNFRSF11A
40x-linked hypophosphatemia10.0CLCN5, DSPP, DMP1
41paget's disease of bone10.0TNFRSF11A, CALCA
42paget disease, juvenile10.0TNFSF11, TNFRSF11A, CALCA
43dental enamel hypoplasia10.0DSPP, HEBP1
44giant cell tumor10.0CALCA, TNFSF11, CTSK
45periapical granuloma10.0TNFSF11
46rickets10.0CLCN5, DSPP, DMP1, HEBP1
47gingivitis10.0IL1A, DSPP, TNFSF11
48cherubism10.0CALCA, TNFSF11, SH3BP2
49short stature10.0CTSK, DSPP, GDF5
50psoriasis10.0IL1A

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to root resorption

Clinical Features for Root Resorption

Drugs & Therapeutics for Root Resorption

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Root Resorption

Drug clinical trials:

Search ClinicalTrials for Root Resorption

Search NIH Clinical Center for Root Resorption

Search CenterWatch for Root Resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

Sources:
33MalaCards
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MalaCards organs/tissues related to Root Resorption:

33
Thyroid, B cells

Animal Models for Root Resorption or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Root Resorption

Sources:
51PubMed
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Articles related to Root Resorption:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Treatment of maxillary central incisor with external root resorption using mineral trioxide aggregate: 18 months follow-up. (23843419)
2013
2
Management of Internal Root Resorption on Permanent Teeth. (24348560)
2013
3
Volumetric measurement of root resorption following molar mini-screw implant intrusion using cone beam computed tomography. (23585866)
2013
4
Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. (22035161)
2012
5
Effects of intrusion combined with anterior retraction on apical root resorption. (21389075)
2012
6
Effect of ultrasonic activation on pH and calcium released by calcium hydroxide pastes in simulated external root resorption. (22595121)
2012
7
Extensive idiopathic external apical root resorption on a 13 year old child. (22838233)
2012
8
Three-dimensional assessment of impacted canines and root resorption using cone beam computed tomography. (22677744)
2012
9
Inflammatory root resorption in primary molars: prevalence and associated factors. (22790498)
2012
10
Periapical tissue reactions to calcium hydroxide and MTA after external root resorption as a sequela of delayed tooth replantation. (22151580)
2012
11
An evaluation of root resorption after orthodontic treatment. (23951798)
2012
12
Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption. (21300248)
2011
13
External apical root resorption in patients treated by serial extractions followed by mechanotherapy. (21300223)
2011
14
Quantitative digital subtraction radiography in the assessment of external apical root resorption induced by orthodontic therapy: a retrospective study. (22269231)
2011
15
Diagnostic accuracy of small volume cone beam computed tomography and intraoral periapical radiography for the detection of simulated external inflammatory root resorption. (21083575)
2011
16
Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force. (20833686)
2011
17
Severe root resorption in orthodontic patients treated with the edgewise method: prevalence and predictive factors. (20197177)
2010
18
Multiple idiopathic apical root resorption: a case report. (21998791)
2010
19
Retreatment of a patient with Marfan syndrome and severe root resorption. (20122440)
2010
20
Repair of root resorption 2 to 16 weeks after the application of continuous forces on maxillary first molars in rats: a 2- and 3-dimensional quantitative evaluation. (20362906)
2010
21
Case report: A cautionary tale of impacted palatal premolars and molar root resorption. (20099607)
2009
22
Disappearing roots. A case of widespread apical root resorption. (19461617)
2009
23
Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar. (19537869)
2009
24
Management of root resorption in a large orthodontic clinic. (20162928)
2009
25
Identification of factors associated with pathological root resorption in traumatized primary teeth. (18489483)
2008
26
Incisor root resorption due to ectopic maxillary canines: a long-term radiographic follow-up. (18298199)
2008
27
Mineral trioxide aggregate as an alternative treatment for intruded permanent teeth with root resorption and incomplete apex formation. (18821965)
2008
28
A radiographic analysis of external apical root resorption of maxillary incisors during active orthodontic treatment. (17229789)
2007
29
Inhibition of orthodontically induced root resorption with echistatin, an RGD-containing peptide. (16473718)
2006
30
Root resorption associated with an impacted mesiodens: a surgical and endodontic approach to treatment. (16942559)
2006
31
Can the severity of root resorption be accurately judged by means of radiographs? A case report with histology. (16027634)
2005
32
Meta analysis of the treatment-related factors of external apical root resorption. (15180086)
2004
33
Root resorption associated with orthodontic force in IL-1Beta knockout mouse. (15758271)
2004
34
The genetic contribution to orthodontic root resorption: a retrospective twin study. (15233581)
2004
35
Root resorption in dental trauma: 45 cases followed for 5 years. (14708650)
2003
36
Expression and role of RANKL in periodontal ligament cells during physiological root-resorption in human deciduous teeth. (12887401)
2003
37
Transient root resorption after dental trauma: the clinician's dilemma. (12762472)
2003
38
Osteoblastoma of the mandible with root resorption: a case report. (12666863)
2003
39
Idiopathic external root resorption associated to hypercalciuria. (11984501)
2002
40
The effect of intracanal Ledermix on root resorption of delayed-replanted monkey teeth. (12656864)
2002
41
Periodontal 5'-deiodination on forced-induced root resorption--the protective effect of thyroid hormone administration. (12198866)
2002
42
Extracanal invasive root resorption: a perplexing oddity. (12029802)
2002
43
Restoration and retention of maxillary anteriors with severe root resorption. (11811745)
2002
44
Effect of topical alendronate on root resorption of dried replanted dog teeth. (11499761)
2001
45
Assessment of root resorption and root shape: periapical vs panoramic films. (11407770)
2001
46
Long-term follow-up of maxillary incisors with severe apical root resorption. (10721249)
2000
47
Are dental anomalies risk factors for apical root resorption in orthodontic patients? (10434093)
1999
48
Root resorption: why, where, and when? (10223897)
1999
49
Correlation between cortical plate proximity and apical root resorption. (9743137)
1998
50
Anomalous dental morphology and root resorption during orthodontic treatment: a pilot study. (10204425)
1998

Genetic Variations for Root Resorption

Expression for genes affiliated with Root Resorption

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for genes affiliated with Root Resorption

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
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Compounds for genes affiliated with Root Resorption

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Root Resorption according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1benzalkonium chloride4510.5DSPP, IL1A
2fluorides4510.5DSPP, CALCA
3laccer4510.5TNFRSF11A, TNFSF11
4silver nitrate4510.4CALCA, DSPP
5ibandronate45 1111.4CALCA, TNFSF11
6polyethylene4510.4TNFRSF11A, TNFSF11, CTSK
7calcium carbonate4510.4CALCA, DSPP
8e 64d45 6011.4CTSK, IL1A
9strontium ranelate4510.4CALCA, TNFSF11, CTSK
10teriparatide45 1111.4CTSK, TNFSF11, CALCA
11denosumab45 1111.4CALCA, TNFRSF11A, TNFSF11
12pmma4510.4CALCA, TNFSF11, DSPP
13zoledronic acid4510.4CALCA, TNFSF11, CTSK
14raloxifene45 29 50 1113.3TNFSF11, TNFRSF11A, CALCA
15alendronate45 50 1112.3CALCA, TNFSF11, DSPP
16vitamin k24510.2TNFSF11, CALCA
17tetracycline45 1111.2IL1A, DSPP, CASP8
18wiki46010.2PARP16, PARP6
19tartrate4510.2DSPP, CTSK, TNFSF11, CALCA
20nu 10256010.2PARP16, PARP6
21jw 556010.2PARP16, PARP6
22sodium fluoride4510.2CALCA, DSPP
23pj 34 hydrochloride6010.2PARP16, PARP6
241,25 dihydroxy vitamin d34510.2IL1A, TNFSF11, TNFRSF11A, CALCA
25xav 9396010.2PARP16, PARP6
26hydroxyapatite4510.1TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP
27pamidronate45 50 1112.1TNFSF11, CALCA
28epinephrine45 11 2412.1CALCA, CASP8, DSPP, IL1A
29calcitriol45 60 11 2413.0IL1A, DSPP, TNFSF11, TNFRSF11A, CALCA
30vitamin d4510.0IL1A, DSPP, DMP1, TNFSF11, CALCA
31h2o2459.9IL1A, CLCN5, DSPP, TNFSF11, CASP8
32risedronate45 60 50 29 1113.8CALCA, TNFSF11
33dexamethasone45 50 29 1112.6IL1A, DSPP, TNFSF11, TNFRSF11A, CASP8
34calcium45 50 11 2412.1CALCA, TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP

GO Terms for genes affiliated with Root Resorption

Sources:
16Gene Ontology
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Cellular components related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.6DSPP, DMP1, AMELX, AMELY
2extracellular spaceGO:0056159.5TNFSF11, CTSK, GDF5, GDF7, IL1A, CALCA

Biological processes related to Root Resorption according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.2TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.2TNFRSF11A, TNFSF11
3mammary gland alveolus developmentGO:06074910.2TNFSF11, TNFRSF11A
4biomineral tissue developmentGO:03121410.1DSPP, DMP1, AMELX, AMELY
5monocyte chemotaxisGO:00254810.1CALCA, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.1TNFRSF11A, TNFSF11
7ossificationGO:00150310.0DSPP, DMP1, TNFSF11, TNFRSF11A
8positive regulation of macrophage differentiationGO:0456519.8CASP8, CALCA

Molecular functions related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.2AMELX, AMELY
2cytokine activityGO:0051259.5IL1A, GDF7, GDF5, TNFSF11

Products for genes affiliated with Root Resorption

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Root Resorption

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet