Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14550
MeSH 41 D012391
UMLS 69 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to chronic apical periodontitis and periodontitis. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Mitogens and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 30.3 TNFRSF11B TNFSF11
2 periodontitis 29.9 CTSK IL1A IL1B TNFRSF11B TNFSF11
3 pulpitis 29.6 DSPP IL1B
4 hypercementosis 29.5 CTSK DSPP SPP1
5 periodontal disease 28.9 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
6 singleton-merten syndrome 1 11.0
7 prosthetic joint infection 10.5 IL1B TNFRSF11B
8 multicentric reticulohistiocytosis 10.4 TNFRSF11B TNFSF11
9 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
10 kummell's disease 10.4 TNFRSF11B TNFSF11
11 vulvar vestibulitis syndrome 10.4 IL1B IL1RN
12 cervicitis 10.4
13 gastric cancer, hereditary diffuse 10.4 IL1B IL1RN
14 schnitzler syndrome 10.4 IL1B IL1RN
15 cerebral artery occlusion 10.4 IL1B IL1RN
16 osteosclerotic myeloma 10.4 IL1B IL1RN
17 fibrogenesis imperfecta ossium 10.4 CALCA TNFRSF11B
18 mevalonic aciduria 10.3 IL1B IL1RN
19 giant cell reparative granuloma 10.3 CALCA TNFRSF11A
20 periodontitis, chronic 10.3 IL1B TNFRSF11B TNFSF11
21 adamantinoma of long bones 10.3 SPP1 TNFSF11
22 polyarticular onset juvenile idiopathic arthritis 10.3 TNFRSF11A TNFRSF11B TNFSF11
23 hemophilic arthropathy 10.3 TNFRSF11A TNFRSF11B TNFSF11
24 familial expansile osteolysis 10.3 TNFRSF11A TNFRSF11B TNFSF11
25 cohen-gibson syndrome 10.3 TNFRSF11A TNFRSF11B TNFSF11
26 hydrarthrosis 10.3 IL1B IL1RN
27 joint disorders 10.3 IL1B IL1RN TNFSF11
28 hypophosphatasia, adult 10.3 CALCA SPP1
29 dental pulp disease 10.2 DSPP IL1B
30 amyloid tumor 10.2 CALCA IL1RN
31 chronic follicular conjunctivitis 10.2 IL1A IL1B
32 vaginal disease 10.2 DSPP IL1B
33 periostitis 10.2 IL1RN TNFRSF11A TNFRSF11B
34 dentin dysplasia, type ii 10.2 DSPP SPP1
35 spondyloarthropathy 1 10.2 IL1RN TNFRSF11B TNFSF11
36 osteoarthritis 10.2 IL1B TNFRSF11B TNFSF11
37 dental pulp calcification 10.2 DSPP SPP1
38 irritant dermatitis 10.2 IL1A IL1B
39 aneurysmal bone cysts 10.2 CALCA TNFRSF11A TNFSF11
40 cinca syndrome 10.2 IL1B IL1RN
41 endometrial disease 10.2 DSPP IL1B
42 aseptic meningitis 10.2 CALCA IL1B IL1RN
43 jaw cancer 10.2 IL1A TNFSF11
44 stachybotrys chartarum 10.2 IL1A IL1B
45 endosteal hyperostosis, autosomal dominant 10.1 CTSK TNFRSF11B TNFSF11
46 gingivitis 10.1
47 limbal stem cell deficiency 10.1 IL1A IL1B
48 osteopetrosis 10.1 CTSK TNFRSF11A TNFSF11
49 dentin dysplasia 10.1 DSPP SPP1
50 bone cancer 10.1 P2RX7 TNFRSF11A TNFSF11

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 TNFRSF11A TNFRSF11B TNFSF11 IL1B SPP1 IL1RN
2 growth/size/body region MP:0005378 10.09 TNFSF11 TNFRSF11A TNFRSF11B RUNX2 IL1B SPP1
3 cardiovascular system MP:0005385 10.02 TNFRSF11B RUNX2 IL1B SPP1 IL1RN P2RX7
4 homeostasis/metabolism MP:0005376 10.02 TNFSF11 TNFRSF11A RUNX2 IL1B SPP1 IL1RN
5 immune system MP:0005387 10.02 TNFRSF11A TNFRSF11B TNFSF11 IL1B SPP1 IL1RN
6 craniofacial MP:0005382 10 TNFRSF11A TNFRSF11B TNFSF11 IL1B SPP1 CTSK
7 integument MP:0010771 9.86 TNFRSF11A TNFSF11 RUNX2 IL1B SPP1 IL1RN
8 limbs/digits/tail MP:0005371 9.63 TNFSF11 TNFRSF11A TNFRSF11B RUNX2 CTSK P2RX7
9 neoplasm MP:0002006 9.35 TNFSF11 TNFRSF11A IL1B SPP1 IL1A
10 skeleton MP:0005390 9.28 TNFRSF11B TNFSF11 IL1B SPP1 IL1RN TNFRSF11A

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 1
2
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
3
Epinephrine Approved, Vet_approved 51-43-4 5816
4
Lidocaine Approved, Vet_approved 137-58-6 3676
5 Racepinephrine Approved 329-65-7
6
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
7
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
8
Alginic acid Approved, Experimental, Investigational 9005-32-7
9
Copper Approved, Investigational 7440-50-8 27099
10
Menthol Approved 2216-51-5 16666
11 Orange Approved, Nutraceutical
12 Anesthetics
13 Anesthetics, Local
14 Calcium, Dietary
15 Chlorhexidine gluconate
16 Epinephryl borate
17 Antifungal Agents
18 Anti-Infective Agents
19 Central Nervous System Depressants
20 Dermatologic Agents
21 Keratolytic Agents
22 Anti-Bacterial Agents
23 Antibiotics, Antitubercular
24 Analgesics
25 Anti-Inflammatory Agents
26
Nickel 7440-02-0 934
27 Bone Density Conservation Agents

Interventional clinical trials:

(show all 37)

# Name Status NCT ID Phase Drugs
1 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound Unknown status NCT00423956 Phase 1, Phase 2
2 Histological Change of The Dentinal-Pulp Complex and Root Resorption Completed NCT01642693 Phase 1, Phase 2
3 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
4 Periodontal Ligament Stress Level and Tooth Movement Completed NCT00099814 Phase 1
5 Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206
6 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
7 Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) - Based Planning and Creation of Orthodontic Appliances Unknown status NCT00871026
8 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment Completed NCT02745626
9 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs Completed NCT02822040
10 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Completed NCT03119779 MTA-Anglus;TheraCal
11 Micro-osteoperforations and Tooth Movement Completed NCT02473471
12 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
13 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565
14 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Completed NCT02359760
15 The Effect of Ultrasound on Orthodontic Tooth Movement Completed NCT01828164
16 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291
17 Intermittent Vibrational Force and Orthodontic Tooth Movement Completed NCT02314975
18 Efficiency of Piezocision-assisted Orthodontic Treatment in Adult Patients Completed NCT02590835
19 Effect of Micro-osteoperforation on the Rate of Canine Retraction Completed NCT03450278
20 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229
21 Labial Alveolar Bone Thickness and Apical Root Resorption Changes Associated With Self-ligating Versus Conventional Brackets Recruiting NCT02816489
22 Orthodontic Archwire Comparison Trial Recruiting NCT02983084
23 Efficacy of Injectable Platelet Rich Fibrin (i-PRF) in Enhancing Bone Quality Recruiting NCT03399760
24 The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances Recruiting NCT03202355
25 The Effect of Different Force Magnitudes on Maxillary Posterior Segment Intrusion Recruiting NCT02901678
26 Closed Window vs. Open Window Technique in Management of Palatally Impacted Canines Recruiting NCT02582645
27 Crossbow Versus Forsus Springs in Mild to Moderate Class II Malocclusion Cases Active, not recruiting NCT01530516
28 Application of Different Biomaterials in the Preservation of Vital Pulp in Carious Deciduous Teeth Active, not recruiting NCT03220360
29 The Impact of Surgical Technique on PDC Active, not recruiting NCT02186548
30 Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy Active, not recruiting NCT02119455
31 Acceleration of Lower Anterior Teeth Leveling and Alignment Using Corticision Active, not recruiting NCT03310086
32 The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Treatment Active, not recruiting NCT02954133
33 The Use of Corticotomy for Upper Incisors Retraction Active, not recruiting NCT03149016
34 Treatment of Crowding Without Extraction Using Self Ligating Brackets Active, not recruiting NCT02996292
35 Evaluation of the Effects of Osteoperforation and Piezocorticision on Canine Retraction Not yet recruiting NCT03308851
36 Orthodontic Archwire Effectiveness Trial Not yet recruiting NCT02659813
37 Randomized, Blinded, Controlled Clinical Trial of Surgically Facilitated Orthodontic Treatment Withdrawn NCT01866345

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

38
Bone, Thyroid

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 656)
# Title Authors Year
1
External apical root resorption. ( 29287651 )
2018
2
Physical properties of root cementum: Part 26. Effects of micro-osteoperforations on orthodontic root resorption: A microcomputed tomography study. ( 29407497 )
2018
3
A comparative study of the effect of the intrusion arch and straight wire mechanics on incisor root resorption: A randomized, controlled trial. ( 28985106 )
2018
4
A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption. ( 29291387 )
2018
5
Effect of EMD on the orthodontically induced root resorption repair process in rats. ( 29396597 )
2018
6
Effects of corticopuncture (CP) and low-level laser therapy (LLLT) on the rate of tooth movement and root resorption in rats using micro-CT evaluation. ( 29282560 )
2017
7
Relationship between root resorption and individual variation in the calcium/phosphorous ratio of cementum. ( 28962729 )
2017
8
Piezocision and root resorption: AA biased conclusion? ( 28554442 )
2017
9
Cellular and Molecular Pathways Leading to External Root Resorption. ( 27811065 )
2017
10
Comparative study of root resorption of maxillary incisors in patients treated with lingual and buccal orthodontics. ( 28737425 )
2017
11
Decoronation: An Alternative Treatment for Replacement Root Resorption. ( 28573052 )
2017
12
Effect of piezocision on root resorption associated with orthodontic force: A microcomputed tomography study. ( 28024782 )
2017
13
Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate-Part 2: Relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone. ( 28906140 )
2017
14
The relationships between the arrangement of teeth, root resorption, and dental maturity in bovine mandibular incisors. ( 29090124 )
2017
15
Management of extensive external apical root resorption leading to root perforation. ( 28978578 )
2017
16
Comparison of 4 and 6A weeks of rest period for repair of root resorption. ( 28670661 )
2017
17
Accessory branch of canalis sinuosus mimicking external root resorption: A diagnostic dilemma. ( 29430105 )
2017
18
Tooth root and alveolar bone grey values derived from cone-beam CT imaging in maxillary incisor tooth with and without apical root resorption. ( 29280412 )
2017
19
The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. ( 28662875 )
2017
20
Multidisciplinary approach for replacement a8"root resorption following severe intrusive luxation: a8"A case report of decoronation. ( 28555199 )
2017
21
Orthodontic-surgical retreatment of facial asymmetry with occlusal cant and severe root resorption: A 3-year follow-up. ( 28760289 )
2017
22
The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial. ( 29016741 )
2017
23
Analysis of the association of clinical factors and IL4 gene polymorphisms with root resorption in avulsed teeth after 1A year of replantation. ( 28617966 )
2017
24
Effects of calcitonin on orthodontic tooth movement and associated root resorption in rats. ( 28814141 )
2017
25
Meloxicam medication reduces orthodontically induced dental root resorption and tooth movement velocity: a combined in vivo and in vitro study of dental-periodontal cells and tissue. ( 28044198 )
2017
26
Management of Ankylotic Root Resorption Following Dental Trauma: A Short Review and Proposal of a Treatment Protocol. ( 28761940 )
2017
27
Assessment of Root Resorption and Root Shape by Periapical and Panoramic Radiographs: A Comparative Study. ( 28621278 )
2017
28
A preliminary investigation of short-termA cytokineA expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study. ( 28762151 )
2017
29
Diagnostic accuracy of phosphor plate systems and conventional radiography in the detection of simulated internal root resorption. ( 28754080 )
2017
30
Impact of cone-beam computed tomography scan mode on the diagnostic yield of chemically simulated external root resorption. ( 28554453 )
2017
31
Severe root resorption of the upper central incisors as a consequence of playing the flute. ( 28602035 )
2017
32
Types of External Root Resorption of Replanted Teeth: Analysis of the Clinical Aspects and of Interleukin-4 Gene Polymorphisms Involvement. ( 28818443 )
2017
33
Atypical root resorption following root fractures in primary teeth. ( 28990014 )
2017
34
Dimensional Evaluation of Root Resorption Areas in Differing Severity of Chronic Periodontitis: A Scanning Electron Microscopic Study. ( 29042731 )
2017
35
Markers in blood and saliva for prediction of orthodontically induced inflammatory root resorption: a retrospective case controlled-study. ( 28782095 )
2017
36
Effects of short-term in-vivo studies on orthodontic root resorption paradigms. ( 28651756 )
2017
37
Management of root resorption with mineral trioxide aggregate complicated by a luxation injury: report of a case with six-year follow-up. ( 28065972 )
2017
38
Comparison between anterior segmental osteotomy versus conventional orthodontic treatment in root resorption: a radiographic study using cone-beam computed tomography. ( 29204418 )
2017
39
Three consecutive days of application of LED therapy is necessary to inhibit experimentally induced root resorption in rats: a microtomographic study. ( 27796672 )
2017
40
Incisor root resorption in class II division 2 patients in relation to orthodontic treatment. ( 29161376 )
2017
41
Management of Invasive Cervical Root Resorption in a Mandibular Canine Using Biodentine as a Restorative Material: A Case Report. ( 28808471 )
2017
42
Some historical musings on tooth/root resorption. ( 29354305 )
2017
43
Correlation of Vitamin D status and orthodontic-induced external apical root resorption. ( 29238379 )
2017
44
Comparative evaluation of the accuracy of two electronic apex locators in determining the working length in teeth with simulated apical root resorption: An in vitro study. ( 27656055 )
2016
45
A radiographic study of external apical root resorption in patients treated with single-phase fixed orthodontic therapy. ( 28050063 )
2016
46
IRAK1 variant is protective for orthodontic-induced external apical root resorption. ( 27250598 )
2016
47
TGF-I^ and Physiological Root Resorption of Deciduous Teeth. ( 28035998 )
2016
48
Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model. ( 26930605 )
2016
49
Multidisciplinary Treatment of Severe Upper Incisor Root Resorption Secondary to Transposed Canine. ( 27491509 )
2016
50
Effect of bisphosphonates on root resorption after tooth replantation - a systematic review. ( 27960049 )
2016

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.45 IL1B TNFRSF11A TNFRSF11B TNFSF11
3 12.35 IL1B IL1RN TNFRSF11A TNFSF11
4
Show member pathways
12.3 IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
12.26 IL1B IL1RN TNFRSF11A TNFSF11
6
Show member pathways
12.13 CTSK TNFRSF11A TNFRSF11B TNFSF11
7
Show member pathways
12.09 IL1A IL1B IL1RN
8 11.96 IL1A IL1B IL1RN
9 11.74 CTSK IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
10 11.68 IL1B TNFRSF11A TNFSF11
11 11.61 CTSK IL1A IL1B TNFRSF11A TNFSF11
12
Show member pathways
11.58 TNFRSF11A TNFRSF11B TNFSF11
13 11.43 CALCA IL1B SPP1
14 11.27 IL1A IL1B IL1RN
15 11.16 IL1A IL1B
16 11.16 IL1A IL1B
17 11.09 RUNX2 SPP1 TNFSF11
18 11.07 IL1A IL1B
19 10.99 IL1A IL1B TNFSF11
20 10.88 CALCA IL1A IL1B RUNX2 SPP1 TNFRSF11A
21 10.8 IL1A IL1B SPP1 TNFSF11
22 10.7 TNFRSF11B TNFSF11
23 10.56 CTSK SPP1 TNFRSF11A TNFRSF11B TNFSF11
24 10.32 IL1A IL1B

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CALCA CTSK IL1A IL1B IL1RN SPP1
2 vesicle GO:0031982 9.33 IL1B IL1RN SPP1
3 extracellular region GO:0005576 9.28 CALCA CTSK DSPP IL1A IL1B IL1RN

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 IL1A IL1B IL1RN TNFRSF11B TNFSF11
2 positive regulation of gene expression GO:0010628 9.91 IL1A IL1B P2RX7 RUNX2
3 extracellular matrix organization GO:0030198 9.85 DSPP SPP1 TNFRSF11B
4 cytokine-mediated signaling pathway GO:0019221 9.81 IL1A IL1B TNFSF11
5 skeletal system development GO:0001501 9.81 DSPP RUNX2 TNFRSF11B
6 response to lipopolysaccharide GO:0032496 9.81 IL1B P2RX7 TNFRSF11A TNFRSF11B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B TNFRSF11A TNFSF11
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.79 TNFRSF11A TNFRSF11B TNFSF11
9 positive regulation of DNA binding transcription factor activity GO:0051091 9.76 IL1B TNFRSF11A TNFSF11
10 apoptotic signaling pathway GO:0097190 9.73 P2RX7 TNFRSF11A TNFRSF11B
11 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1A IL1B
12 biomineral tissue development GO:0031214 9.67 DSPP SPP1
13 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.67 IL1A IL1B
14 positive regulation of cytokine secretion GO:0050715 9.66 IL1A P2RX7
15 positive regulation of interleukin-8 production GO:0032757 9.66 CALCA IL1B
16 positive regulation of vascular endothelial growth factor production GO:0010575 9.65 IL1A IL1B
17 positive regulation of mitotic nuclear division GO:0045840 9.65 IL1A IL1B
18 osteoclast differentiation GO:0030316 9.65 TNFRSF11A TNFSF11
19 positive regulation of interleukin-6 production GO:0032755 9.65 IL1A IL1B P2RX7
20 bone resorption GO:0045453 9.64 CTSK TNFSF11
21 monocyte chemotaxis GO:0002548 9.63 CALCA TNFRSF11A TNFSF11
22 response to ATP GO:0033198 9.62 IL1B P2RX7
23 mammary gland alveolus development GO:0060749 9.62 TNFRSF11A TNFSF11
24 ossification GO:0001503 9.62 DSPP RUNX2 TNFRSF11A TNFSF11
25 embryo implantation GO:0007566 9.61 CALCA IL1B SPP1
26 positive regulation of bone resorption GO:0045780 9.6 SPP1 TNFSF11
27 positive regulation of ossification GO:0045778 9.59 CALCA P2RX7
28 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.58 IL1A IL1B
29 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.57 IL1A IL1B
30 positive regulation of prostaglandin secretion GO:0032308 9.55 IL1B P2RX7
31 ectopic germ cell programmed cell death GO:0035234 9.54 IL1A IL1B
32 regulation of receptor activity GO:0010469 9.5 CALCA IL1A IL1B IL1RN SPP1 TNFRSF11B
33 TNFSF11-mediated signaling pathway GO:0071847 9.49 TNFRSF11A TNFSF11
34 negative regulation of bone resorption GO:0045779 9.43 CALCA P2RX7 TNFRSF11B
35 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFRSF11A TNFSF11
36 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.37 TNFRSF11A TNFSF11
37 fever generation GO:0001660 9.33 IL1A IL1B IL1RN
38 inflammatory response GO:0006954 9.23 CALCA IL1A IL1B IL1RN P2RX7 SPP1

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF11A TNFRSF11B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 cytokine activity GO:0005125 9.1 IL1A IL1B IL1RN SPP1 TNFRSF11B TNFSF11

Sources for Root Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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