MCID: RTR008
MIFTS: 36

Root Resorption malady

Oral diseases category
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Summaries for Root Resorption

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 In dentistry, root resorption is the breakdown or destruction, and subsequent loss, of the root... more...

MalaCards: Root Resorption is related to cervicitis and periodontitis. An important gene associated with Root Resorption is AMELX (amelogenin, X-linked), and among its related pathways is Degradation of the extracellular matrix. The compounds hydrogen and hydroxyapatite have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Root Resorption

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8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

root resorption 8 10 62


External Ids:

Disease Ontology8 DOID:14550
MeSH35 D012391

Related Diseases for Root Resorption

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Root Resorption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis10.7
2periodontitis10.7
3gingivitis10.4
4atopic dermatitis10.2
5dermatitis10.2
6periodontal disease10.2
7ankylosis10.1
8hereditary hemorrhagic telangiectasia10.1
9osteoblastoma10.1
10gingival recession10.1
11fibroma10.1
12amelogenesis imperfecta10.1
13neuronitis10.1
14hypercementosis10.1
15fibrous dysplasia10.1
16marfan syndrome10.1
17ehlers-danlos syndrome10.1
18scleroderma10.1
19thyroiditis10.1
20ehlers-danlos syndrome, type viii10.1
21x-linked hypophosphatemia10.0DMP1, CLCN5
22hypophosphatemia10.0DMP1, CLCN5
23rickets10.0CLCN5, DMP1
24arthritis10.0CTSK, GDF5
25short stature9.9GDF5, CTSK
26osteoarthritis9.9GDF5, CTSK

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to root resorption

Symptoms for Root Resorption

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Drugs & Therapeutics for Root Resorption

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Root Resorption

Search NIH Clinical Center for Root Resorption

Genetic Tests for Root Resorption

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Anatomical Context for Root Resorption

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33MalaCards
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MalaCards organs/tissues related to Root Resorption:

33
Bone, Thyroid

Animal Models for Root Resorption or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Root Resorption:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5CTSK, DMP1, GDF5
2MP:00053828.1DMP1, AMELX, CLCN5, CTSK
3MP:00053907.4CTSK, CLCN5, AMELX, DMP1, GDF5

Publications for Root Resorption

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52PubMed
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Articles related to Root Resorption:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
A comparison of apical root resorption after orthodontic treatment with surgical exposure and traction of maxillary impacted canines versus that without impactions. (24406478)
2014
2
Comparison between electrochemical ELISA and spectrophotometric ELISA for the detection of dentine sialophosphoprotein for root resorption. (24373653)
2014
3
The effect of ovalbumin on orthodontic induced root resorption. (24348621)
2013
4
Treatment of maxillary central incisor with external root resorption using mineral trioxide aggregate: 18 months follow-up. (23843419)
2013
5
The effect of celecoxib on orthodontic tooth movement and root resorption in rat. (24396349)
2013
6
Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. (24118270)
2013
7
Radiographic comparison of the extent of orthodontically induced external apical root resorption in vital and root-filled teeth: a systematic review. (23321851)
2013
8
Association between root resorption incident to orthodontic treatment and treatment factors. (23142948)
2013
9
Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog. (22051114)
2012
10
Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. (22035161)
2012
11
Icariin enhances the healing of rapid palatal expansion induced root resorption in rats. (22818561)
2012
12
Aggressive external root resorption of the entire dentition accompanied by osteolysis: a case report. (22930767)
2012
13
Effects of intrusion combined with anterior retraction on apical root resorption. (21389075)
2012
14
Localized idiopathic apical root resorption: a report of five cases with emphasis on differential diagnosis. (22479784)
2012
15
Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. (22621214)
2012
16
Primary teeth show less protecting factors against root resorption. (21481035)
2011
17
Physical properties of root cementum: Part 16. Comparisons of root resorption and resorption craters after the application of light and heavy continuous and controlled orthodontic forces for 4, 8, and 12 weeks. (21392672)
2011
18
Tooth movement and root resorption; the effect of ovariectomy on orthodontic force application in rats. (21361777)
2011
19
Root resorption caused by a maxillary sinus mucocele: a case report. (21444223)
2011
20
Root resorption in the furcation area: a differential diagnostic consideration. (20629542)
2010
21
Repair of root resorption 4 and 8 weeks after application of continuous light and heavy forces on premolars for 4 weeks: a histology study. (21130331)
2010
22
Case report: A cautionary tale of impacted palatal premolars and molar root resorption. (20099607)
2009
23
Interleukin-1 polymorphisms in relation to external apical root resorption (EARR). (19194673)
2009
24
Detection of root resorption using dentin and bone markers. (19627525)
2009
25
Treatment of aggressive external root resorption with calcium hydroxide medicaments: a case report. (19519861)
2009
26
Ectopic maxillary canines and root resorption of adjacent incisors. Does computed tomography (CT) influence decision-making by orthodontists? (19172919)
2008
27
Three-dimensional mechanical environment of orthodontic tooth movement and root resorption. (18538239)
2008
28
Radiographic evaluation of the prevalence of root resorption in a Middle Eastern population. (18560639)
2008
29
The effect of intracanal anti-inflammatory medicaments on external root resorption of replanted dog teeth after extended extra-oral dry time. (18173671)
2008
30
Tooth movement characteristics in relation to root resorption in young and adult rats. (18028051)
2007
31
The flaws in tooth root resorption assessment algorithms: the role of source position. (17699700)
2007
32
Lateral incisor root resorption and active orthodontic treatment in the early mixed dentition. (18163854)
2007
33
Root resorption after orthodontic treatment. (17203580)
2006
34
Inflammatory external root resorption following surgical treatment for intra-bony defects: a report of two cases involving Emdogain and a review of the literature. (16677335)
2006
35
Labially impacted maxillary canines causing severe root resorption of maxillary central incisors. (16448288)
2006
36
Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa beta ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars. (16214633)
2005
37
Can the severity of root resorption be accurately judged by means of radiographs? A case report with histology. (16027634)
2005
38
Pulp-dentine complex changes and root resorption during intrusive orthodontic tooth movement in patients prescribed nabumetone. (15614010)
2005
39
Severe external root resorption arrested by conventional endodontic treatment. (15938342)
2005
40
Root resorption in dental trauma: 45 cases followed for 5 years. (14708650)
2003
41
Prevalence of different periapical lesions associated with human teeth and their correlation with the presence and extension of apical external root resorption. (12196225)
2002
42
Combined therapy of mineral trioxide aggregate and guided tissue regeneration in the treatment of external root resorption and an associated osseous defect. (12546103)
2002
43
In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption. (12067130)
2002
44
Deciduous canine and permanent lateral incisor differential root resorption. (11606957)
2001
45
Root resorption. (11270379)
2001
46
Root resorption in elderly patients. (15208929)
2001
47
Apical root resorption of upper first molars as related to anchorage system. (11140541)
2000
48
Evaluation of apical root resorption following extraction therapy in subjects with Class I and Class II malocclusions. (10565089)
1999
49
Radiographic assessment of simulated external root resorption cavities in maxillary incisors. (9863423)
1998
50
Ultrastructural and cytochemical study of the odontoclasts in physiologic root resorption of human deciduous teeth. (1328451)
1992

Variations for Root Resorption

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Expression for genes affiliated with Root Resorption

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Root Resorption

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Pathways for genes affiliated with Root Resorption

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50PathCards, 55Reactome
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Pathways related to Root Resorption according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.5CTSK, DMP1, GDF5

Compounds for genes affiliated with Root Resorption

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45Novoseek, 24HMDB
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Compounds related to Root Resorption according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydrogen45 2410.3CTSK, CLCN5
2hydroxyapatite459.2CTSK, DMP1
3chloride459.0CTSK, CLCN5

GO Terms for genes affiliated with Root Resorption

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16Gene Ontology
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Cellular components related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.2AMELX, DMP1
2extracellular regionGO:0055768.5CTSK, DMP1, GDF5

Biological processes related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:0312149.4AMELX, DMP1
2chondrocyte differentiationGO:0020629.2AMELX, GDF5
3extracellular matrix organizationGO:0301988.2CTSK, DMP1, GDF5

Molecular functions related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2AMELX, GDF5

Products for genes affiliated with Root Resorption

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Root Resorption

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet