MCID: RTR008
MIFTS: 43

Root Resorption malady

Summaries for Root Resorption

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63Wikipedia, 32MalaCards
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Wikipedia:63 In dentistry, root resorption is the breakdown or destruction, and subsequent loss, of the root... more...

MalaCards: Root Resorption is related to periodontitis and gingivitis. An important gene associated with Root Resorption is AMELY (amelogenin, Y-linked), and among its related pathways are BAFF in B-Cell Signaling and Osteoclast Signaling. The compounds benzalkonium chloride and fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Root Resorption

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH
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Aliases & Descriptions:

root resorption 8 10 60


External Ids:

Disease Ontology8 DOID:14550
MeSH34 D012391

Related Diseases for Root Resorption

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Root Resorption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis30.9IL1A
2gingivitis30.6IL1A, DSPP, TNFSF11
3periodontal disease30.3TNFRSF11A, TNFSF11, DSPP, IL1A
4gingival recession30.0DSPP
5ankylosis30.0GDF7, GDF5, HEBP1
6dental pulp necrosis30.0AMELX, AMELY
7amelogenesis imperfecta30.0AMELY, AMELX, DSPP
8tooth resorption10.9
9cervicitis10.7
10atopic dermatitis10.2
11root caries10.2
12dermatitis10.2
13marfan syndrome10.1
14external pathological resorption10.1
15osteoblastoma10.1
16hereditary hemorrhagic telangiectasia10.1
17hypercementosis10.1
18cleft lip10.1
19neuronitis10.1
20cleft palate10.1
21adenomatoid tumor10.1
22fibrous dysplasia10.1
23ehlers-danlos syndrome10.1
24scleroderma10.1
25thyroiditis10.1
26turner syndrome10.0AMELX, AMELY
27dermatomyositis10.0IL1A
28hepatitis10.0CASP8
29dental fluorosis10.0AMELX, AMELY
30giant cell reparative granuloma10.0SH3BP2
31dental caries10.0DSPP
32multiple myeloma10.0TNFSF11
33osteomyelitis10.0TNFSF11, CTSK
34dentinogenesis imperfecta 110.0DSPP, DMP1
35chondrosarcoma10.0CTSK
36osteosclerosis10.0CTSK, TNFSF11
37dentinogenesis imperfecta10.0DMP1, DSPP
38polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11
39pulpitis10.0IL1A, DSPP
40hepatitis b10.0CASP8
41osteomalacia10.0DMP1, CALCA
42osteopetrosis10.0CTSK, TNFSF11, TNFRSF11A
43x-linked hypophosphatemia10.0CLCN5, DSPP, DMP1
44paget's disease of bone10.0TNFRSF11A, CALCA
45paget disease, juvenile10.0TNFSF11, TNFRSF11A, CALCA
46dental enamel hypoplasia10.0DSPP, HEBP1
47giant cell tumor10.0CALCA, TNFSF11, CTSK
48periapical granuloma10.0TNFSF11
49rickets10.0CLCN5, DSPP, DMP1, HEBP1
50cherubism10.0CALCA, TNFSF11, SH3BP2

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to root resorption

Clinical Features for Root Resorption

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Drugs & Therapeutics for Root Resorption

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Root Resorption

Drug clinical trials:

Search ClinicalTrials for Root Resorption

Search NIH Clinical Center for Root Resorption

Search CenterWatch for Root Resorption

Genetic Tests for Root Resorption

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Anatomical Context for Root Resorption

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32MalaCards
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MalaCards organs/tissues related to Root Resorption:

32
Bone, Thyroid

Animal Models for Root Resorption or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Root Resorption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.4CASP8, TNFRSF11A, CTNNBIP1, CTSK, SH3BP2, CALCA
2MP:00053828.9CLCN5, AMELX, TNFRSF11A, TNFSF11, CTNNBIP1, CTSK
3MP:00053908.8AMELX, TNFRSF11A, TNFSF11, CTNNBIP1, CTSK, DMP1

Publications for Root Resorption

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Sources:
50PubMed
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Articles related to Root Resorption:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Apical root resorption during orthodontic treatment with aligners? A retrospective radiometric study. (23941626)
2013
2
IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. (22882407)
2013
3
Effect of allergen sensitization on external root resorption. (23648742)
2013
4
Extensive idiopathic external root resorption in first maxillary molar: a case report. (23717334)
2013
5
Failure of treatment of impacted canines associated with invasive cervical root resorption. (23343004)
2013
6
Quantification of external root resorption by low- vs high-resolution cone-beam computed tomography and periapical radiography: A volumetric and linear analysis. (23273363)
2013
7
Apical root resorption: the dark side of the root. (23561410)
2013
8
Apical root resorption due to orthodontic treatment detected by cone beam computed tomography. (22812378)
2013
9
Occurrence of cervical invasive root resorption in first and second molar teeth of orthodontic patients eight years after bracket removal. (23228253)
2013
10
Aggressive external root resorption of the entire dentition accompanied by osteolysis: a case report. (22930767)
2012
11
Root resorption after orthodontic treatment: a review. (22873024)
2012
12
Apical root resorption caused by orthodontic forces: A brief review and a long-term observation. (23077427)
2012
13
Pulp extirpation within 14 days after tooth replantation reduces inflammatory root resorption. (22547721)
2012
14
Physical properties of root cementum: Part 17. Root resorption after the application of 2.5A^ and 15A^ of buccal root torque for 4 weeks: a microcomputed tomography study. (21457842)
2011
15
Apical root resorption: a prospective radiographic study of maxillary incisors. (21769274)
2011
16
Dental root resorption: a review of the literature and a proposed new classification. (23738861)
2011
17
Repair of root resorption 4 and 8 weeks after application of continuous light and heavy forces on premolars for 4 weeks: a histology study. (21130331)
2010
18
Management of inflammatory root resorption using MTA obturation - a four year follow up. (20379243)
2010
19
Single-session use of mineral trioxide aggregate as an apical barrier in a case of external root resorption. (20587960)
2010
20
Causes and treatment of root resorption. (20632619)
2010
21
Experimental orthodontic tooth movement and extensive root resorption: periodontal and pulpal changes. (21083621)
2010
22
Anabolic effect of intermittent PTH(1-34) on the local microenvironment during the late phase of periodontal repair in a rat model of tooth root resorption. (19280233)
2010
23
Oral focal mucinosis associated with cervical external root resorption: a case report. (20674412)
2010
24
Comparison between two tomographic sections in the diagnosis of external root resorption. (20857012)
2010
25
Treatment of aggressive external root resorption with calcium hydroxide medicaments: a case report. (19519861)
2009
26
Double 'pink tooth' associated with extensive internal root resorption after orthodontic treatment: a case report. (19239482)
2009
27
Effect of calcium hydroxide-based materials on periapical tissue healing and orthodontic root resorption of endodontically treated teeth in dogs. (19290903)
2009
28
Orthodontic treatment of a patient with severe class II malocclusion, bony fibrous dysplasia, root resorptions, and missing four premolars. (20349617)
2009
29
Root resorption and irreversible damage to the paradental Structures associated with orthodontic treatment. (19927951)
2009
30
An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice. (19705931)
2009
31
Rapidly progressive internal root resorption: a case report. (18821960)
2008
32
Root resorption following treatment with aligners. (18947291)
2008
33
External apical root resorption: two case reports. (19133089)
2008
34
Evaluation of root resorption associated with orthodontic movement in stressed rats. (19092753)
2008
35
Lateral incisor root resorption and active orthodontic treatment in the early mixed dentition. (18163854)
2007
36
Density value means in the evaluation of external apical root resorption: an in vitro study for early detection in orthodontic case simulations. (17463096)
2007
37
Insulin-like growth factor system components in the periodontium during tooth root resorption and early repair processes in the rat. (16911103)
2006
38
RANKL increase in compressed periodontal ligament cells from root resorption. (16861294)
2006
39
Expression of mRNA for osteoprotegerin and receptor activator of nuclear factor kappa beta ligand (RANKL) during root resorption induced by the application of heavy orthodontic forces on rat molars. (16214633)
2005
40
Apical root resorption of maxillary first molars after intrusion with zygomatic skeletal anchorage. (16283814)
2005
41
Root resorption after orthodontic intrusion and extrusion: an intraindividual study. (16448231)
2005
42
Endodontics: Part 9. Calcium hydroxide, root resorption, endo-perio lesions. (15608732)
2004
43
Repair of orthodontically induced root resorption by ultrasound in humans. (15316473)
2004
44
Cervical root resorption in two patients with unilateral complete cleft of the lip and palate. (12190343)
2002
45
Predicting and preventing root resorption: Part II. Treatment factors. (11343023)
2001
46
Ehlers-Danlos syndrome type VIII with severe periodontitis and apical root resorption after orthodontic treatment. (10721840)
2000
47
Radiographic assessment of simulated external root resorption cavities in maxillary incisors. (9863423)
1998
48
Film and digital radiography for detection of simulated root resorption cavities. (9690255)
1998
49
Effect of systemic tetracycline and amoxicillin on inflammatory root resorption of replanted dogs' teeth. (9855800)
1998
50
Therapeutic delivery of calcitonin to inhibit external inflammatory root resorption. I. Diffusion kinetics of calcitonin through the dental root. (9206373)
1996

Genetic Variations for Root Resorption

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Expression for genes affiliated with Root Resorption

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for genes affiliated with Root Resorption

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Root Resorption

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Root Resorption according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1benzalkonium chloride4410.5DSPP, IL1A
2fluorides4410.5DSPP, CALCA
3laccer4410.5TNFRSF11A, TNFSF11
4silver nitrate4410.4CALCA, DSPP
5ibandronate44 1111.4CALCA, TNFSF11
6polyethylene4410.4TNFRSF11A, TNFSF11, CTSK
7calcium carbonate4410.4CALCA, DSPP
8e 64d44 5911.4CTSK, IL1A
9strontium ranelate4410.4CALCA, TNFSF11, CTSK
10teriparatide44 1111.4CTSK, TNFSF11, CALCA
11denosumab44 1111.4CALCA, TNFRSF11A, TNFSF11
12pmma4410.4CALCA, TNFSF11, DSPP
13zoledronic acid4410.4CALCA, TNFSF11, CTSK
14raloxifene44 28 49 1113.3TNFSF11, TNFRSF11A, CALCA
15alendronate44 49 1112.3CALCA, TNFSF11, DSPP
16vitamin k24410.2TNFSF11, CALCA
17tetracycline44 1111.2IL1A, DSPP, CASP8
18wiki45910.2PARP16, PARP6
19tartrate4410.2DSPP, CTSK, TNFSF11, CALCA
20nu 10255910.2PARP16, PARP6
21jw 555910.2PARP16, PARP6
22sodium fluoride4410.2CALCA, DSPP
23pj 34 hydrochloride5910.2PARP16, PARP6
241,25 dihydroxy vitamin d34410.2IL1A, TNFSF11, TNFRSF11A, CALCA
25xav 9395910.2PARP16, PARP6
26hydroxyapatite4410.1TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP
27pamidronate44 49 1112.1TNFSF11, CALCA
28epinephrine44 11 2412.1CALCA, CASP8, DSPP, IL1A
29calcitriol44 59 11 2413.0IL1A, DSPP, TNFSF11, TNFRSF11A, CALCA
30vitamin d4410.0IL1A, DSPP, DMP1, TNFSF11, CALCA
31h2o2449.9IL1A, CLCN5, DSPP, TNFSF11, CASP8
32risedronate44 59 49 28 1113.8CALCA, TNFSF11
33dexamethasone44 49 28 1112.6IL1A, DSPP, TNFSF11, TNFRSF11A, CASP8
34calcium44 49 11 2412.1CALCA, TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP

GO Terms for genes affiliated with Root Resorption

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16Gene Ontology
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Cellular components related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.6DSPP, DMP1, AMELX, AMELY
2extracellular spaceGO:0056159.5TNFSF11, CTSK, GDF5, GDF7, IL1A, CALCA

Biological processes related to Root Resorption according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.2TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.2TNFRSF11A, TNFSF11
3mammary gland alveolus developmentGO:06074910.2TNFSF11, TNFRSF11A
4biomineral tissue developmentGO:03121410.1DSPP, DMP1, AMELX, AMELY
5monocyte chemotaxisGO:00254810.1CALCA, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.1TNFRSF11A, TNFSF11
7ossificationGO:00150310.0DSPP, DMP1, TNFSF11, TNFRSF11A
8positive regulation of macrophage differentiationGO:0456519.8CASP8, CALCA

Molecular functions related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.2AMELX, AMELY
2cytokine activityGO:0051259.5IL1A, GDF7, GDF5, TNFSF11

Products for genes affiliated with Root Resorption

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Root Resorption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet