MCID: RTR008
MIFTS: 42

Root Resorption malady

Categories: Oral diseases

Aliases & Classifications for Root Resorption

Aliases & Descriptions for Root Resorption:

Name: Root Resorption 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14550
MeSH 42 D012391
UMLS 69 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to singleton-merten syndrome 1 and cervicitis. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Alendronate and Diphosphonates have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 singleton-merten syndrome 1 10.9
2 cervicitis 10.3
3 periodontitis 10.3
4 pseudoainhum 10.3 IL1B TNFRSF11B
5 cortical blindness 10.3 TNFRSF11B TNFSF11
6 extrahepatic bile duct leiomyosarcoma 10.3 TNFRSF11A TNFSF11
7 peripheral scars of retina 10.3 TNFRSF11B TNFSF11
8 hepatocellular carcinoma 10.2 IL1B IL1RN
9 stickler syndrome 10.2 CALCA TNFRSF11B
10 egg allergy 10.2 IL1B IL1RN
11 warthin tumor 10.2 IL1B IL1RN
12 atrial heart septal defect 10.2 CALCA TNFRSF11A
13 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11A TNFRSF11B TNFSF11
14 hepatic fibrosis renal cysts mental retardation 10.2 TNFRSF11A TNFRSF11B TNFSF11
15 epilepsy, idiopathic generalized 14 10.2 TNFRSF11A TNFRSF11B TNFSF11
16 polyomavirus allograft nephropathy 10.2 TNFRSF11A TNFRSF11B TNFSF11
17 keratoconus 10.2 IL1B IL1RN TNFSF11
18 hypophosphatasia, adult 10.2 CALCA SPP1
19 cocaine dependence 10.2 IL1RN TNFRSF11A TNFRSF11B
20 toxic optic neuropathy 10.1 IL1A IL1B
21 celiac disease 10.1 IL1RN TNFRSF11B TNFSF11
22 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.1 SPP1 TNFRSF11B TNFSF11
23 chromosome 16q22 deletion syndrome 10.1 CALCA TNFRSF11A TNFSF11
24 senile reticular retinal degeneration 10.1 CALCA IL1B IL1RN
25 porokeratosis 3, disseminated superficial actinic 10.1 IL1B IL1RN
26 bazex syndrome 10.1 CALCA IL1RN
27 exudative vitreoretinopathy 4 10.1 CTSK TNFRSF11B TNFSF11
28 anal paget's disease 10.1 IL1A IL1B
29 pancreatic ductal adenocarcinoma 10.1 CTSK TNFRSF11A TNFSF11
30 osteonecrosis 10.1 IL1B TNFRSF11B TNFSF11
31 oral cavity carcinoma in situ 10.1 IL1B IL1RN P2RX7
32 synovium cancer 10.1 IL1B IL1RN TNFRSF11B TNFSF11
33 myofascial pain syndrome 10.0 CALCA CTSK SPP1
34 mental retardation hypotonia skin hyperpigmentation 10.0 IL1A IL1B IL1RN
35 vascular dementia 10.0 IL1A TNFRSF11B TNFSF11
36 testicular leydig cell tumor 10.0 IL1A IL1B IL1RN
37 immunoglobulin g deficiency 10.0 IL1A IL1B IL1RN
38 phka2-related phosphorylase kinase deficiency 10.0 CALCA TNFRSF11A TNFRSF11B TNFSF11
39 birk-barel mental retardation dysmorphism syndrome 10.0 CALCA TNFRSF11A TNFRSF11B TNFSF11
40 skin conditions 10.0 IL1A IL1B IL1RN
41 adermatoglyphia 10.0 DSPP SPP1
42 bare lymphocyte syndrome, type i 10.0 IL1A IL1B IL1RN
43 bladder papillary transitional cell neoplasm 10.0 CALCA TNFRSF11A TNFRSF11B TNFSF11
44 intracranial hemorrhage in brain cerebrovascular malformations 10.0 IL1A IL1B IL1RN
45 granuloma annulare 10.0 DSPP IL1B
46 microcephaly 10, primary, autosomal recessive 10.0 CTSK TNFRSF11A TNFRSF11B TNFSF11
47 gingivitis 10.0
48 chromosomal disease 10.0 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
49 adenosquamous breast carcinoma 10.0 DSPP SPP1
50 molybdenum cofactor deficiency a 10.0 IL1A IL1B TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
2 homeostasis/metabolism MP:0005376 10.02 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
3 immune system MP:0005387 10.02 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
4 cardiovascular system MP:0005385 10 IL1A IL1B IL1RN P2RX7 RUNX2 SPP1
5 craniofacial MP:0005382 9.91 CTSK RUNX2 SPP1 TNFRSF11A TNFRSF11B TNFSF11
6 integument MP:0010771 9.86 TNFRSF11A TNFSF11 IL1A IL1B IL1RN P2RX7
7 limbs/digits/tail MP:0005371 9.63 CTSK P2RX7 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
8 neoplasm MP:0002006 9.35 IL1A IL1B SPP1 TNFRSF11A TNFSF11
9 skeleton MP:0005390 9.28 TNFRSF11A TNFRSF11B TNFSF11 CTSK IL1B IL1RN

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
2 Diphosphonates Phase 4
3 Bone Density Conservation Agents Phase 4
4 Rosuvastatin Calcium Phase 2, Phase 3 147098-20-2
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2, Phase 3
6 Hypolipidemic Agents Phase 2, Phase 3
7 Anticholesteremic Agents Phase 2, Phase 3
8 Lipid Regulating Agents Phase 2, Phase 3
9 Antimetabolites Phase 2, Phase 3
10 Calcium, Dietary Phase 2, Phase 3
11 Mitogens Phase 1
12
Epinephrine Approved, Vet_approved 51-43-4 5816
13
Acetaminophen Approved 103-90-2 1983
14
Salicylic acid Approved, Vet_approved 69-72-7 338
15
Copper Approved 15158-11-9, 7440-50-8 27099
16
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
17
Lidocaine Approved, Vet_approved 137-58-6 3676
18
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
19
Menthol Approved 2216-51-5 16666
20
Glycine Approved, Nutraceutical, Vet_approved 56-40-6 750
21
Methylene blue Investigational 61-73-4
22 Anesthetics
23 Anesthetics, Local
24
Nickel 7440-02-0 934
25 Chlorhexidine gluconate
26 Analgesics
27
Alginic acid 9005-32-7
28 Dermatologic Agents
29 Epinephryl borate
30 Pharmaceutical Solutions
31 Anti-Bacterial Agents
32 Anti-Infective Agents
33 Anti-Inflammatory Agents
34 Antifungal Agents
35 Keratolytic Agents
36 Racepinephrine
37 Antibiotics, Antitubercular
38 Central Nervous System Depressants
39 Photosensitizing Agents
40 Soy Bean Nutraceutical
41 Goji Nutraceutical
42 Orange Nutraceutical
43 Angelica Nutraceutical
44 Eleuthero Nutraceutical
45 Lycium Nutraceutical

Interventional clinical trials:

(show all 46)
id Name Status NCT ID Phase
1 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4
2 Efficacy of Socket Grafting for Alveolar Ridge Preservation Completed NCT01794806 Phase 4
3 A Comparision of Collagen Matrix and Connective Tissue Graft With Modified Coronally Advanced Tunnel for Root Coverage Recruiting NCT02876562 Phase 4
4 Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium Terminated NCT01806974 Phase 4
5 Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis Completed NCT02283515 Phase 2, Phase 3
6 The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis Completed NCT03178526 Phase 2, Phase 3
7 Interest of Bone Substitute Material in Immediate Complete Denture Recruiting NCT02120053 Phase 2, Phase 3
8 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound Unknown status NCT00423956 Phase 1, Phase 2
9 Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling Unknown status NCT00228280 Phase 1, Phase 2
10 Histological Change of The Dentinal-Pulp Complex and Root Resorption Completed NCT01642693 Phase 1, Phase 2
11 Evaluation of SilOss® in Periodontal Surgery Completed NCT02639572 Phase 2
12 Periodontal Ligament Stress Level and Tooth Movement Completed NCT00099814 Phase 1
13 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
14 Treatment of Crowding Without Extraction Using Self Ligating Brackets Recruiting NCT02996292 Phase 1
15 Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206
16 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Unknown status NCT02359760
17 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
18 Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) - Based Planning and Creation of Orthodontic Appliances Unknown status NCT00871026
19 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment Completed NCT02745626
20 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs Completed NCT02822040
21 Micro-osteoperforations and Tooth Movement Completed NCT02473471
22 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
23 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565
24 The Effect of Ultrasound on Orthodontic Tooth Movement Completed NCT01828164
25 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291
26 Intermittent Vibrational Force and Orthodontic Tooth Movement Completed NCT02314975
27 Efficiency of Piezocision-assisted Orthodontic Treatment in Adult Patients Completed NCT02590835
28 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229
29 Titanium Prepared Platelet Rich Fibrin for Multiple Gingival Recessions Completed NCT03121872
30 Disc Resorption in Lumbar and Cervical Disc Herniation Patients Receiving Integrative Korean Medicine Treatment Completed NCT02841163
31 Labial Alveolar Bone Thickness and Apical Root Resorption Changes Associated With Self-ligating Versus Conventional Brackets Recruiting NCT02816489
32 Orthodontic Archwire Comparison Trial Recruiting NCT02983084
33 The Impact of Surgical Technique on PDC Recruiting NCT02186548
34 Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy Recruiting NCT02119455
35 The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Treatment Recruiting NCT02954133
36 The Effect of Different Force Magnitudes on Maxillary Posterior Segment Intrusion Recruiting NCT02901678
37 The Use of Corticotomy for Upper Incisors Retraction Recruiting NCT03149016
38 Closed Window vs. Open Window Technique in Management of Palatally Impacted Canines Recruiting NCT02582645
39 Analysis of Soluble TREM (Triggering Receptor Expressed on Myeloid Cells)-1 and -2 in Crevicular Fluid and Associated Bacterial Flora in Patients Affected by Periodontitis Recruiting NCT02873949
40 Treatment of Post-Extraction Dehisced Socket - A Case Series Study Recruiting NCT02980211
41 Crossbow Versus Forsus Springs in Mild to Moderate Class II Malocclusion Cases Active, not recruiting NCT01530516
42 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Active, not recruiting NCT03119779
43 Evaluation of Antimicrobial Photodynamic Therapy for the Treatment of Deep Carious Lesions in Children: an in Vivo Study Active, not recruiting NCT02908789
44 Orthodontic Archwire Effectiveness Trial Not yet recruiting NCT02659813
45 Effect of Enamel Matrix Proteins on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients Not yet recruiting NCT02972788
46 Randomized, Blinded, Controlled Clinical Trial of Surgically Facilitated Orthodontic Treatment Withdrawn NCT01866345

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

39
Bone, Thyroid

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 618)
id Title Authors Year
1
Management of root resorption with mineral trioxide aggregate complicated by a luxation injury: report of a case with six-year follow-up. ( 28065972 )
2017
2
Meloxicam medication reduces orthodontically induced dental root resorption and tooth movement velocity: a combined in vivo and in vitro study of dental-periodontal cells and tissue. ( 28044198 )
2017
3
Effect of piezocision on root resorption associated with orthodontic force: A microcomputed tomography study. ( 28024782 )
2017
4
Three consecutive days of application of LED therapy is necessary to inhibit experimentally induced root resorption in rats: a microtomographic study. ( 27796672 )
2017
5
Cellular and Molecular Pathways Leading to External Root Resorption. ( 27811065 )
2017
6
Asymptomatic, nonexpansile radiopacity of the jaw associated with external root resorption: a diagnostic dilemma. ( 26742164 )
2016
7
Association of genetic polymorphism and external apical root resorption: A systematic review. ( 27148771 )
2016
8
Osteoprotegerin-Knockout Mice Developed Early Onset Root Resorption. ( 27663616 )
2016
9
Expression of Inflammatory Cytokines and Chemokines in Replanted Permanent Teeth with External Root Resorption. ( 28024757 )
2016
10
BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption. ( 27021457 )
2016
11
Orthodontic Treatment of Maxillary Incisors with Severe Root Resorption Caused by Bilateral Canine Impaction in a Class II Division 1 Patient. ( 26950820 )
2016
12
Cone-beam computed tomography versus periapical radiograph for diagnosing external root resorption: A systematic review and meta-analysis. ( 27813424 )
2016
13
Diagnostic Accuracy of Cone-Beam Computed Tomography and Periapical Radiography in Internal Root Resorption. ( 26843878 )
2016
14
Quantitive evaluation of dentin sialoprotein (DSP) using microbeads - a potential early marker of root resorption. ( 28042441 )
2016
15
Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model. ( 27647761 )
2016
16
A radiographic study of external apical root resorption in patients treated with single-phase fixed orthodontic therapy. ( 28050063 )
2016
17
Management of progressive apical root resorption 13 years after dental trauma and primary endodontic treatment. ( 27367638 )
2016
18
Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners. ( 27504821 )
2016
19
Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model. ( 27838559 )
2016
20
IRAK1 variant is protective for orthodontic-induced external apical root resorption. ( 27250598 )
2016
21
Genetic determinants and postorthodontic external apical root resorption in Czech children. ( 27493142 )
2016
22
External root resorption of the second molar associated with mesially and horizontally impacted mandibular third molar: evidence from cone beam computed tomography. ( 27316639 )
2016
23
Regenerative Endodontic Procedures for Traumatized Teeth after Horizontal Root Fracture, Avulsion, and Perforating Root Resorption. ( 27576211 )
2016
24
Effects of Low-Intensity Pulsed Ultrasound on Orthodontic Tooth Movement and Orthodontically Induced Inflammatory Root Resorption in Ovariectomized Osteoporotic Rats. ( 26742893 )
2016
25
A posteriori registration and subtraction of periapical radiographs for the evaluation of external apical root resorption after orthodontic treatment. ( 27051635 )
2016
26
Scanning electron microscopy reveals severe external root resorption in the large periapical lesion. ( 26957368 )
2016
27
TGF-I^ and Physiological Root Resorption of Deciduous Teeth. ( 28035998 )
2016
28
Interdisciplinary Approach for Management of Iatrogenic Internal Root Resorption: A Case Report. ( 26843882 )
2016
29
Comparison of anterior and posterior mini-implant-assisted maxillary incisor intrusion: Root resorption and treatment efficiency. ( 26741306 )
2016
30
The Effect of An Angiogenic Cytokine on Orthodontically Induced Inflammatory Root Resorption. ( 27551674 )
2016
31
External root resorption with the self-ligating Damon system-a retrospective study. ( 27365168 )
2016
32
Cone-beam computed tomography evaluation of the association of cortical plate proximity and apical root resorption after orthodontic treatment. ( 27349544 )
2016
33
Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats. ( 26790630 )
2016
34
Evaluation of cone beam computed tomography and periapical radiography in the diagnosis of root resorption. ( 26780040 )
2016
35
Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events. ( 27119080 )
2016
36
Effect of Voxel Size on Detection of External Root Resorption Defects Using Cone Beam Computed Tomography. ( 27853499 )
2016
37
Conservative Management of Class 4 Invasive Cervical Root Resorption Using Calcium-enriched Mixture Cement. ( 27316319 )
2016
38
Effect of bisphosphonates on root resorption after tooth replantation - a systematic review. ( 27960049 )
2016
39
RANKL and OPG expression: Jiggling force affects root resorption in rats. ( 27341651 )
2016
40
Management of Root Resorption Using Chemical Agents: A Review. ( 26843869 )
2016
41
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial. ( 26950808 )
2016
42
Multidisciplinary Treatment of Severe Upper Incisor Root Resorption Secondary to Transposed Canine. ( 27491509 )
2016
43
The effect of canine disimpaction performed with temporary anchorage devices (TADs) before comprehensive orthodontic treatment to avoid root resorption of adjacent teeth. ( 27275617 )
2016
44
Clinical Management of Two Root Resorption Cases in Endodontic Practice. ( 27648314 )
2016
45
Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: A multicenter randomized clinical trial. ( 27894540 )
2016
46
Impacted maxillary canines and root resorption of adjacent teeth: A retrospective observational study. ( 27694788 )
2016
47
Genetic and clinical risk factors of root resorption associated with orthodontic treatment. ( 27476361 )
2016
48
Conservative management of external root resorption after tooth reimplantation: a 3-year follow-up. ( 27367632 )
2016
49
Canine-lateral incisor transposition: Controlling root resorption with a bone-anchored T-loop retraction. ( 27894525 )
2016
50
Comparative evaluation of the accuracy of two electronic apex locators in determining the working length in teeth with simulated apical root resorption: An in vitro study. ( 27656055 )
2016

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.56 IL1B TNFRSF11A TNFRSF11B TNFSF11
3 12.33 IL1B IL1RN TNFRSF11A TNFSF11
4
Show member pathways
12.3 IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
12.25 IL1B IL1RN TNFRSF11A TNFSF11
6
Show member pathways
12.13 CTSK TNFRSF11A TNFRSF11B TNFSF11
7
Show member pathways
12.08 IL1A IL1B IL1RN
8 11.96 IL1A IL1B IL1RN
9 11.74 CTSK IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
10 11.68 IL1B TNFRSF11A TNFSF11
11
Show member pathways
11.62 TNFRSF11A TNFRSF11B TNFSF11
12 11.61 CTSK IL1A IL1B TNFRSF11A TNFSF11
13 11.43 CALCA IL1B SPP1
14 11.27 IL1A IL1B IL1RN
15 11.16 IL1A IL1B
16 11.15 IL1A IL1B
17 11.09 RUNX2 SPP1 TNFSF11
18 11.07 IL1A IL1B
19 10.99 IL1A IL1B TNFSF11
20 10.88 CALCA IL1A IL1B RUNX2 SPP1 TNFRSF11A
21 10.7 TNFRSF11B TNFSF11
22 10.56 CTSK SPP1 TNFRSF11A TNFRSF11B TNFSF11
23 10.32 IL1A IL1B

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CTSK DSPP IL1A IL1B IL1RN
2 vesicle GO:0031982 9.33 IL1B IL1RN SPP1
3 extracellular space GO:0005615 9.23 CALCA CTSK IL1A IL1B IL1RN SPP1

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 IL1A IL1B IL1RN TNFRSF11B TNFSF11
2 positive regulation of gene expression GO:0010628 9.89 IL1A IL1B P2RX7 RUNX2
3 extracellular matrix organization GO:0030198 9.85 DSPP SPP1 TNFRSF11B
4 cytokine-mediated signaling pathway GO:0019221 9.81 IL1A IL1B TNFSF11
5 skeletal system development GO:0001501 9.8 DSPP RUNX2 TNFRSF11B
6 response to lipopolysaccharide GO:0032496 9.8 IL1B P2RX7 TNFRSF11A TNFRSF11B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 IL1B TNFRSF11A TNFSF11
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.78 TNFRSF11A TNFRSF11B TNFSF11
9 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.75 IL1B TNFRSF11A TNFSF11
10 apoptotic signaling pathway GO:0097190 9.71 P2RX7 TNFRSF11A TNFRSF11B
11 biomineral tissue development GO:0031214 9.67 DSPP SPP1
12 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.66 IL1A IL1B
13 positive regulation of cytokine secretion GO:0050715 9.66 IL1A P2RX7
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.65 IL1A IL1B
15 positive regulation of mitotic nuclear division GO:0045840 9.65 IL1A IL1B
16 positive regulation of interleukin-8 production GO:0032757 9.65 CALCA IL1B
17 osteoclast differentiation GO:0030316 9.64 TNFRSF11A TNFSF11
18 bone resorption GO:0045453 9.64 CTSK TNFSF11
19 embryo implantation GO:0007566 9.63 CALCA IL1B SPP1
20 response to ATP GO:0033198 9.62 IL1B P2RX7
21 mammary gland alveolus development GO:0060749 9.61 TNFRSF11A TNFSF11
22 positive regulation of interleukin-6 production GO:0032755 9.61 IL1A IL1B P2RX7
23 positive regulation of ossification GO:0045778 9.6 CALCA P2RX7
24 positive regulation of bone resorption GO:0045780 9.58 SPP1 TNFSF11
25 monocyte chemotaxis GO:0002548 9.58 CALCA TNFRSF11A TNFSF11
26 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.57 IL1A IL1B
27 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.56 IL1A IL1B
28 ectopic germ cell programmed cell death GO:0035234 9.55 IL1A IL1B
29 positive regulation of prostaglandin secretion GO:0032308 9.52 IL1B P2RX7
30 TNFSF11-mediated signaling pathway GO:0071847 9.48 TNFRSF11A TNFSF11
31 ossification GO:0001503 9.46 DSPP RUNX2 TNFRSF11A TNFSF11
32 fever generation GO:0001660 9.37 IL1A IL1B
33 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.32 TNFRSF11A TNFSF11
34 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.26 TNFRSF11A TNFSF11
35 inflammatory response GO:0006954 9.23 CALCA IL1A IL1B IL1RN P2RX7 SPP1
36 negative regulation of bone resorption GO:0045779 9.13 CALCA P2RX7 TNFRSF11B

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF11A TNFRSF11B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 cytokine activity GO:0005125 9.1 IL1A IL1B IL1RN SPP1 TNFRSF11B TNFSF11

Sources for Root Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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