MCID: RTR008
MIFTS: 43

Root Resorption malady

Summaries for Root Resorption

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63Wikipedia, 32MalaCards
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Wikipedia:63 In dentistry, root resorption is the breakdown or destruction, and subsequent loss, of the root... more...

MalaCards: Root Resorption is related to periodontitis and gingivitis. An important gene associated with Root Resorption is AMELY (amelogenin, Y-linked), and among its related pathways are BAFF in B-Cell Signaling and Osteoclast Signaling. The compounds benzalkonium chloride and fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Classifications for Root Resorption

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH
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Aliases & Descriptions:

root resorption 8 10 60


External Ids:

Disease Ontology8 DOID:14550
MeSH34 D012391

Related Diseases for Root Resorption

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Root Resorption via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis30.9IL1A
2gingivitis30.6IL1A, DSPP, TNFSF11
3periodontal disease30.3TNFRSF11A, TNFSF11, DSPP, IL1A
4gingival recession30.0DSPP
5ankylosis30.0GDF7, GDF5, HEBP1
6dental pulp necrosis30.0AMELX, AMELY
7amelogenesis imperfecta30.0AMELY, AMELX, DSPP
8tooth resorption10.9
9cervicitis10.7
10atopic dermatitis10.2
11root caries10.2
12dermatitis10.2
13marfan syndrome10.1
14external pathological resorption10.1
15osteoblastoma10.1
16hereditary hemorrhagic telangiectasia10.1
17hypercementosis10.1
18cleft lip10.1
19neuronitis10.1
20cleft palate10.1
21adenomatoid tumor10.1
22fibrous dysplasia10.1
23ehlers-danlos syndrome10.1
24scleroderma10.1
25thyroiditis10.1
26turner syndrome10.0AMELX, AMELY
27dermatomyositis10.0IL1A
28hepatitis10.0CASP8
29dental fluorosis10.0AMELX, AMELY
30giant cell reparative granuloma10.0SH3BP2
31dental caries10.0DSPP
32multiple myeloma10.0TNFSF11
33osteomyelitis10.0TNFSF11, CTSK
34dentinogenesis imperfecta 110.0DSPP, DMP1
35chondrosarcoma10.0CTSK
36osteosclerosis10.0CTSK, TNFSF11
37dentinogenesis imperfecta10.0DMP1, DSPP
38polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11
39pulpitis10.0IL1A, DSPP
40hepatitis b10.0CASP8
41osteomalacia10.0DMP1, CALCA
42osteopetrosis10.0CTSK, TNFSF11, TNFRSF11A
43x-linked hypophosphatemia10.0CLCN5, DSPP, DMP1
44paget's disease of bone10.0TNFRSF11A, CALCA
45paget disease, juvenile10.0TNFSF11, TNFRSF11A, CALCA
46dental enamel hypoplasia10.0DSPP, HEBP1
47giant cell tumor10.0CALCA, TNFSF11, CTSK
48periapical granuloma10.0TNFSF11
49rickets10.0CLCN5, DSPP, DMP1, HEBP1
50cherubism10.0CALCA, TNFSF11, SH3BP2

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to root resorption

Clinical Features for Root Resorption

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Drugs & Therapeutics for Root Resorption

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Root Resorption

Drug clinical trials:

Search ClinicalTrials for Root Resorption

Search NIH Clinical Center for Root Resorption

Search CenterWatch for Root Resorption

Genetic Tests for Root Resorption

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Anatomical Context for Root Resorption

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32MalaCards
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MalaCards organs/tissues related to Root Resorption:

32
Bone, Thyroid

Animal Models for Root Resorption or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Root Resorption:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.4CASP8, TNFRSF11A, CTNNBIP1, CTSK, SH3BP2, CALCA
2MP:00053828.9CLCN5, AMELX, TNFRSF11A, TNFSF11, CTNNBIP1, CTSK
3MP:00053908.8AMELX, TNFRSF11A, TNFSF11, CTNNBIP1, CTSK, DMP1

Publications for Root Resorption

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50PubMed
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Articles related to Root Resorption:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. (24396427)
2014
2
The effect of celecoxib on orthodontic tooth movement and root resorption in rat. (24396349)
2013
3
Long-term evaluation of apical root resorption after orthodontic treatment using periapical radiography and cone beam computed tomography. (24262423)
2013
4
Multiple idiopathic apical root resorption. (23616336)
2013
5
Prediction of maxillary lateral-incisor root resorption using sector analysis of potentially impacted canines. (24121399)
2013
6
Icariin enhances the healing of rapid palatal expansion induced root resorption in rats. (22818561)
2012
7
Localized idiopathic apical root resorption: a report of five cases with emphasis on differential diagnosis. (22479784)
2012
8
Treatment of perforating internal root resorption with MTA: a case report. (22466897)
2012
9
Nonsurgical endodontic retreatment of advanced inflammatory external root resorption using mineral trioxide aggregate obturation. (23304567)
2012
10
Pre-treatment radiographic features predict root resorption of treated impacted maxillary central incisors. (22812442)
2012
11
Comparison of root resorption between self-ligating and conventional preadjusted brackets using cone beam computed tomography. (22409394)
2012
12
In vitro comparison of cone beam computed tomography with different voxel sizes for detection of simulated external root resorption. (23047032)
2012
13
Ultrasound enhances the healing of orthodontically induced root resorption in rats. (21787199)
2012
14
Apical root resorption during orthodontic treatment. A prospective study using cone beam CT. (21919826)
2012
15
Association between root resorption incident to orthodontic treatment and treatment factors. (21811005)
2012
16
Apical root resorption in maxillary incisors when employing micro-implant and J-hook headgear anchorage: a 4-month radiographic study. (23073811)
2012
17
Severe root resorption and orthodontic treatment: clinical implications after 25 years of follow-up. (21435537)
2011
18
Root resorption associated with ectopically erupting maxillary permanent canines: a computed tomography study. (21127168)
2011
19
Treatment of severe inflammatory root resorption in a young permanent incisor with mineral trioxide aggregate. (21846458)
2011
20
Physical properties of root cementum: part 20. Effect of fluoride on orthodontically induced root resorption with light and heavy orthodontic forces for 4 weeks: a microcomputed tomography study. (22051498)
2011
21
Comparisons of the effects of systemic administration of L-thyroxine and doxycycline on orthodontically induced root resorption in rats. (20100785)
2010
22
Accuracy of an electronic apex locator in primary teeth with root resorption. (19134039)
2009
23
Analysis of orthodontically induced root resorption using micro-computed tomography (Micro-CT). (19123716)
2009
24
Identification of orthodontic patients at risk of severe apical root resorption. (19361730)
2009
25
Physical properties of root cementum: part 12. The incidence of physiologic root resorption on unerupted third molars and its comparison with orthodontically treated premolars: a microcomputed-tomography study. (19651333)
2009
26
Ectopic maxillary canines and root resorption of adjacent incisors. Does computed tomography (CT) influence decision-making by orthodontists? (19172919)
2008
27
External apical root resorption in patients treated with conventional and self-ligating brackets. (18984396)
2008
28
Simulated root resorption: a new study model. (24265639)
2008
29
Histological analysis of orthodontic root resorption in rats treated with the cyclooxygenase-2 (COX-2) inhibitor celecoxib. (18713152)
2008
30
Cellular and extracellular factors in early root resorption repair in the rat. (18632841)
2008
31
Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption. (18456142)
2008
32
Diagnostic accuracy of digitized periapical radiographs validated against micro-computed tomography scanning in evaluating orthodontically induced apical root resorption. (18821990)
2008
33
Root resorption of a maxillary permanent first molar by an impacted second premolar. (17351585)
2007
34
Traumatic injury to permanent tooth resulting in complete root resorption: a case report. (18195520)
2007
35
Influence of steroid drugs on orthodontically induced root resorption. (16420276)
2006
36
Severe external root resorption arrested by conventional endodontic treatment. (15938342)
2005
37
External cervical root resorption involving multiple maxillary teeth in a patient with hereditary hemorrhagic telangiectasia. (16243244)
2005
38
GENETIC FACTORS IN EXTERNAL APICAL ROOT RESORPTION AND ORTHODONTIC TREATMENT. (15059946)
2004
39
Characteristics of patients with severe root resorption. (15180089)
2004
40
Root resorption in human mandibular first premolars after rotation as detected by scanning electron microscopy. (15316472)
2004
41
Two cases of molar root resorption. (12830697)
2003
42
Cervical external root resorption in vital teeth. (12296786)
2002
43
Electronic determination of root canal length in primary teeth with and without root resorption. (12059916)
2002
44
Predicting and preventing root resorption: Part I. Diagnostic factors. (11343022)
2001
45
Root resorption after orthodontic treatment in high- and low-risk patients: analysis of allergy as a possible predisposing factor. (11212601)
2000
46
A radiographic comparison of apical root resorption after orthodontic treatment with a standard edgewise and a straight-wire edgewise technique. (11212602)
2000
47
Evaluation of apical root resorption following extraction therapy in subjects with Class I and Class II malocclusions. (10565089)
1999
48
Root resorption of first permanent molar by a supernumerary premolar. (10765756)
1999
49
Continuous vs. discontinuous force application and root resorption. (10227557)
1999
50
External root resorption in orthodontics: avoiding high risk teeth. A case report. (9722412)
1998

Genetic Variations for Root Resorption

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Expression for genes affiliated with Root Resorption

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for genes affiliated with Root Resorption

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Root Resorption

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Root Resorption according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1benzalkonium chloride4410.5DSPP, IL1A
2fluorides4410.5DSPP, CALCA
3laccer4410.5TNFRSF11A, TNFSF11
4silver nitrate4410.4CALCA, DSPP
5ibandronate44 1111.4CALCA, TNFSF11
6polyethylene4410.4TNFRSF11A, TNFSF11, CTSK
7calcium carbonate4410.4CALCA, DSPP
8e 64d44 5911.4CTSK, IL1A
9strontium ranelate4410.4CALCA, TNFSF11, CTSK
10teriparatide44 1111.4CTSK, TNFSF11, CALCA
11denosumab44 1111.4CALCA, TNFRSF11A, TNFSF11
12pmma4410.4CALCA, TNFSF11, DSPP
13zoledronic acid4410.4CALCA, TNFSF11, CTSK
14raloxifene44 28 49 1113.3TNFSF11, TNFRSF11A, CALCA
15alendronate44 49 1112.3CALCA, TNFSF11, DSPP
16vitamin k24410.2TNFSF11, CALCA
17tetracycline44 1111.2IL1A, DSPP, CASP8
18wiki45910.2PARP16, PARP6
19tartrate4410.2DSPP, CTSK, TNFSF11, CALCA
20nu 10255910.2PARP16, PARP6
21jw 555910.2PARP16, PARP6
22sodium fluoride4410.2CALCA, DSPP
23pj 34 hydrochloride5910.2PARP16, PARP6
241,25 dihydroxy vitamin d34410.2IL1A, TNFSF11, TNFRSF11A, CALCA
25xav 9395910.2PARP16, PARP6
26hydroxyapatite4410.1TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP
27pamidronate44 49 1112.1TNFSF11, CALCA
28epinephrine44 11 2412.1CALCA, CASP8, DSPP, IL1A
29calcitriol44 59 11 2413.0IL1A, DSPP, TNFSF11, TNFRSF11A, CALCA
30vitamin d4410.0IL1A, DSPP, DMP1, TNFSF11, CALCA
31h2o2449.9IL1A, CLCN5, DSPP, TNFSF11, CASP8
32risedronate44 59 49 28 1113.8CALCA, TNFSF11
33dexamethasone44 49 28 1112.6IL1A, DSPP, TNFSF11, TNFRSF11A, CASP8
34calcium44 49 11 2412.1CALCA, TNFRSF11A, TNFSF11, CTSK, DMP1, DSPP

GO Terms for genes affiliated with Root Resorption

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16Gene Ontology
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Cellular components related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.6DSPP, DMP1, AMELX, AMELY
2extracellular spaceGO:0056159.5TNFSF11, CTSK, GDF5, GDF7, IL1A, CALCA

Biological processes related to Root Resorption according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.2TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:07184710.2TNFRSF11A, TNFSF11
3mammary gland alveolus developmentGO:06074910.2TNFSF11, TNFRSF11A
4biomineral tissue developmentGO:03121410.1DSPP, DMP1, AMELX, AMELY
5monocyte chemotaxisGO:00254810.1CALCA, TNFRSF11A, TNFSF11
6positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.1TNFRSF11A, TNFSF11
7ossificationGO:00150310.0DSPP, DMP1, TNFSF11, TNFRSF11A
8positive regulation of macrophage differentiationGO:0456519.8CASP8, CALCA

Molecular functions related to Root Resorption according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.2AMELX, AMELY
2cytokine activityGO:0051259.5IL1A, GDF7, GDF5, TNFSF11

Products for genes affiliated with Root Resorption

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Root Resorption

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet