MCID: RSC001
MIFTS: 57

Rosacea malady

Skin diseases category

Summaries for Rosacea

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it most often affects middle-aged and older adults. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin, and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. there is no cure, but treatments can help. they include medicines and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rosacea, also known as acne, erythematosa, is related to dermatitis and psoriasis. An important gene associated with Rosacea is CAMP (cathelicidin antimicrobial peptide), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The drugs benzoyl peroxide and metronidazole and the compounds bpde and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and small intestine.

Wikipedia:63 Rosacea /roʊˈzeɪʃiə/ is a chronic condition characterized by facial erythema (redness) and... more...

Aliases & Classifications for Rosacea

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

rosacea 8 10 33 60
acne, erythematosa 8
acne rosacea 8
rosacea nos 8
acne roscea 8


External Ids:

Disease Ontology8 DOID:8881
MeSH34 D012393
ICD9CM27 695.3
ICD1025 L71, L71.9

Related Diseases for Rosacea

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rosacea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.7IL18
2psoriasis30.3CAMP, S100A8, IL18, KDR, ADSL
3leukemia30.1S100A8, KDR, GSTM1, GSTT1, GSTP1
4atopic dermatitis30.0ADSL, KLK5
5lupus erythematosus29.8IL18
6migraine29.8GSTM1
7pneumonia29.8GSTM1, MMP8, S100A8
8basal cell carcinoma29.8GSTT1, GSTM1, MMP3
9inflammatory bowel disease29.8S100A8, IL18, MMP3, ALPI
10stomach cancer29.8S100A8, MMP3, KDR, GSTM1, GSTT1, GSTP1
11acne10.8
12granulomatous rosacea10.5
13skin disease10.3
14rosacea conjunctivitis10.2
15contact dermatitis10.2
16blepharitis10.2
17granulomatous dermatitis10.1
18eye disease10.1
19keratitis10.1
20keratoconjunctivitis10.1
21crohn's disease10.0
22keratoconjunctivitis sicca10.0
23occupational dermatitis10.0
24wegener's granulomatosis10.0
25ulcerative colitis10.0
26sporotrichosis10.0
27allergic contact dermatitis10.0
28conjunctivitis10.0
29pyoderma10.0
30nephrotic syndrome10.0CETP
31periodontitis10.0MMP8
32peritonitis10.0MMP8
33duodenitis10.0S100A8
34gingivitis10.0MMP8
35myeloma10.0MMP8
36periodontal disease10.0MMP3
37sarcoidosis10.0IL18
38pulmonary emphysema10.0MMP8
39hellp syndrome10.0GSTP1
40liver cirrhosis10.0ALPI, CETP
41glaucoma10.0GSTP1
42kawasaki disease10.0MMP3
43pancreatitis10.0GSTP1
44deficiency anemia10.0GSTM1
45acute pancreatitis10.0IL18
46gastritis10.0S100A8
47funisitis10.0MMP8
48myocardial infarction10.0GSTT1, CETP
49malignant mesothelioma10.0KDR
50cleft palate10.0GSTM1

Graphical network of the top 20 diseases related to Rosacea:



Diseases related to rosacea

Clinical Features for Rosacea

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Drugs & Therapeutics for Rosacea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Rosacea

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Anatomical Context for Rosacea

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rosacea:

32
Skin, Eye, Small intestine, B cells, Endothelial, Salivary gland, Testes, Myeloid

Animal Models for Rosacea or affiliated genes

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Publications for Rosacea

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Sources:
50PubMed
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Articles related to Rosacea:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Facial verrucous sporotrichosis in an adult during treatment for rosacea. (23557535)
2014
2
Steroid dermatitis resembling rosacea: a clinical evaluation of 75 patients. (23691345)
2013
3
Cutaneous B-cell chronic lymphocytic leukaemia resembling a granulomatous rosacea. (24139373)
2013
4
Symptom severity and psychological sequelae in rosacea: Results of a survey. (24088195)
2013
5
Rosacea fulminans. (23961522)
2013
6
Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases. (22340024)
2013
7
Changes in digestive enzyme activities during larval development of leopard grouper (Mycteroperca rosacea). (24189829)
2013
8
No link between rosacea and Propionibacterium acnes. (23009116)
2012
9
Rosacea: update on management and emerging therapies. (23223767)
2012
10
Central corneal thickness in patients with mild to moderate rosacea. (23217504)
2012
11
Tacrolimus-induced rosacea-like dermatitis: a clinical analysis of 16 cases associated with tacrolimus ointment application. (22626964)
2012
12
Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. (22189789)
2012
13
Contact hypersensitivity in rosacea--a study in 82 patients. (21929553)
2012
14
Management of Papulopustular Rosacea and Perioral Dermatitis with Emphasis on Iatrogenic Causation or Exacerbation of Inflammatory Facial Dermatoses: Use of Doxycycline-modified Release 40mg Capsule Once Daily in Combination with Properly Selected Skin Care as an Effective Therapeutic Approach. (21909455)
2011
15
Efficacy of 1% terbinafine cream in comparison with 0.75% metronidazole gel for the treatment of papulopustular rosacea. (21166608)
2011
16
Intense pulsed light for the treatment of rosacea and telangiectasias. (21848421)
2011
17
Treatment of ocular rosacea with 40 mg doxycycline in a slow release form. (21672164)
2011
18
Use of intense pulsed light to treat refractory granulomatous rosacea. (20402938)
2010
19
Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea. (20079929)
2010
20
Updates on the pathophysiology and management of acne rosacea. (19820288)
2009
21
Results of a national rosacea patient survey: common issues that concern rosacea sufferers. (19213226)
2009
22
Correlation of the severity of cutaneous rosacea with ocular rosacea. (19584472)
2009
23
Efficacy of topical cyclosporine for the treatment of ocular rosacea. (19551353)
2009
24
Concentration of selected cytokines in serum of patients with acne rosacea]. (19140384)
2008
25
Rosacea/acne rosacea: efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment. (18435734)
2008
26
Granulomatous rosacea in infants. Report of three cases and discussion of the differential diagnosis. (18700125)
2008
27
Chronic epiphora secondary to ocular rosacea. (18520861)
2008
28
Rosacea-like demodicidosis. (19022195)
2008
29
Pseudodendritic keratitis in ocular rosacea causing a diagnostic dilemma. (17951915)
2007
30
Information from your family doctor. Rosacea: what you should know. (17375521)
2007
31
Azelaic acid (15% gel) in the treatment of acne rosacea. (17472690)
2007
32
Update on rosacea and anti-inflammatory-dose doxycycline. (17315050)
2007
33
Rosacea in a monozygotic twin. (17535206)
2007
34
An update on the role of topical metronidazole in rosacea. (16598386)
2006
35
Pimecrolimus cream 1% is effective in a case of granulomatous rosacea. (16585999)
2006
36
Rosacea: wonderings of a clinician. (16983894)
2006
37
Rosacea, light, and phototherapy. (15898288)
2005
38
Topical metronidazole combination therapy in the clinical management of rosacea. (16004021)
2005
39
Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study. (16197374)
2005
40
Poikiloderma of civatte and rosacea: variants in the same nosological spectrum? (16286759)
2005
41
Pimecrolimus for treatment of acne rosacea. (15891250)
2005
42
Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. (16209160)
2005
43
BsmI polymorphism of the vitamin D receptor gene in patients with the fulminant course of rosacea conglobata (rosacea fulminans). (15187348)
2004
44
Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. (14989398)
2004
45
Rosacea: a clinicopathological approach. (15459529)
2004
46
The nosology of rosacea. (15499751)
2004
47
Rosacea in the pediatric population. (15379362)
2004
48
Effects of minocycline on the ocular flora of patients with acne rosacea or seborrheic blepharitis. (12883348)
2003
49
Granulomatous rosacea associated with Demodex folliculorum. (1399202)
1992
50
Granulomatous rosacea. (4244176)
1970

Genetic Variations for Rosacea

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Expression for genes affiliated with Rosacea

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for genes affiliated with Rosacea

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Rosacea

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Rosacea according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1bpde4410.7GSTP1
2butyrate4410.5CAMP, ALPI
3dcnb4410.4GSTP1, GSTM1
4(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1110.4GSTP1, GSTM1
5n-(2-hydroxyethyl)valine4410.4GSTT1, GSTM1
6methylchloride4410.4GSTP1, GSTT1, GSTM1
7drugs for treatment of tuberculosis4910.4GSTT1, GSTM1
8s-phenylmercapturic acid4410.4GSTM1, GSTT1, GSTP1
91,3-butadiene4410.4GSTM1, GSTT1, GSTP1
10cumene hydroperoxide4410.4GSTM1, GSTT1, GSTP1
11styrene4410.4GSTM1, GSTT1, GSTP1
121-hydroxypyrene4410.4GSTM1, GSTT1, GSTP1
13trichloroethylene4410.3GSTP1, GSTT1, GSTM1
14noradrenochrome44 2411.3GSTM1, GSTT1, GSTP1
15marimastat44 59 1112.3MMP3, MMP8, KDR
16hydrochloric acid44 2411.3GSTM1, GSTT1, GSTP1
17adrenochrome44 2411.3GSTM1, GSTT1, GSTP1
18alendronate44 49 1112.2IL18, MMP3, MMP8
19acetone4410.2GSTM1, GSTT1, GSTP1
20hydrocarbons4410.2GSTM1, GSTT1, GSTP1
211-chloro-24-dinitrobenzene4410.2GSTP1, GSTT1, GSTM1, IL18
228-oxo-dg4410.2S100A8, GSTM1, GSTT1
23mspi4410.2CETP, GSTM1, GSTT1
24cyclophosphamide44 49 1112.2GSTP1, GSTT1, GSTM1, KDR
25carboplatin44 49 1112.1KDR, GSTM1, GSTT1, GSTP1
26trans,trans-muconic acid4410.1GSTM1, GSTT1
27chi 24410.1S100A8, IL18, GSTM1, GSTT1
28allergens4410.1S100A8, SCP2, IL18, CETP
29p0024410.1IL18, MMP3, MMP8, GSTM1, GSTT1
30gsts4410.0GSTM1, GSTT1, GSTP1
31urea44 11 2412.0S100A8, MMP3, MMP8, ADSL
32simvastatin44 49 59 28 11 2415.0IL18, MMP3, KDR, CETP
33folate4410.0IL18, KDR, GSTM1, GSTT1, GSTP1
34ifosfamide44 1111.0GSTP1, GSTT1, GSTM1
352,4,6-trinitrotoluene4410.0GSTM1, GSTP1
36ascorbic acid44 2411.0GSTP1, GSTT1, GSTM1, CETP, MMP3
37valine4410.0ILVBL, CETP, GSTM1, GSTT1, GSTP1
38Glutathione11 2410.9GSTP1, GSTT1, GSTM1
39methotrexate44 49 1111.9S100A8, IL18, MMP3, GSTM1, GSTP1
40lactate449.8IL18, MMP3, MMP8, KDR, GSTM1, GSTP1
41doxorubicin44 49 1111.8GSTP1, GSTT1, GSTM1, KDR, IL18
42arginine449.7NISCH, IL18, KDR, CETP, GSTM1, GSTT1
43serine449.6KLK5, CAMP, S100A8, IL18, MMP3, MMP8
44estrogen449.6CAMP, IL18, MMP3, KDR, CETP, GSTM1
45cholesterol44 28 11 2412.6CAMP, S100A8, SCP2, IL18, MMP3, CETP
46retinoic acid44 2410.5CAMP, S100A8, IL18, MMP3, MMP8, KDR
47cysteine449.4S100A8, IL18, MMP3, MMP8, KDR, CETP
48creatinine449.4GSTP1, S100A8, IL18, MMP3, ALPI, ADSL
49genistein44 28 59 2 11 2414.4CAMP, MMP3, MMP8, KDR, GSTP1
50lipid449.2NISCH, SCP2, S100A8, CAMP, IL18, MMP3

GO Terms for genes affiliated with Rosacea

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16Gene Ontology
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Cellular components related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4CETP, MMP8, MMP3, IL18, S100A8, KLK5
2extracellular regionGO:0055768.8CETP, KLK5, CAMP, S100A8, IL18, MMP3

Biological processes related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid transportGO:01591410.2CETP, SCP2
2glutathione derivative biosynthetic processGO:19016879.9GSTP1, GSTT1, GSTM1
3glutathione metabolic processGO:0067499.8GSTM1, GSTT1, GSTP1
4positive regulation of superoxide anion generationGO:0329309.8GSTP1, IL18

Molecular functions related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.9GSTP1, GSTT1, GSTM1

Products for genes affiliated with Rosacea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rosacea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet