Aliases & Classifications for Rosacea

Aliases & Descriptions for Rosacea:

Name: Rosacea 12 41 42 14 69
Acne, Erythematosa 12
Acne Roscea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8881
ICD10 33 L71 L71.9
ICD9CM 35 695.3
MeSH 42 D012393
NCIt 47 C97136
UMLS 69 C0035854

Summaries for Rosacea

MedlinePlus : 41 rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it most often affects middle-aged and older adults. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin, and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. there is no cure, but treatments can help. they include medicines and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Rosacea, also known as acne, erythematosa, is related to granulomatous rosacea and rosacea conjunctivitis, and has symptoms including exanthema and pruritus. An important gene associated with Rosacea is CAMP (Cathelicidin Antimicrobial Peptide), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Diseases associated with the TLR signaling cascade. The drugs Doxycycline and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and b cells, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Rosacea is a long-term skin condition characterized by facial redness, small and superficial dilated... more...

Related Diseases for Rosacea

Diseases related to Rosacea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 granulomatous rosacea 12.4
2 rosacea conjunctivitis 11.8
3 acne 10.4
4 aminoaciduria 10.2 MMP8 MMP9
5 dermatitis 10.2
6 kidney osteogenic sarcoma 10.2 MMP9 VEGFA
7 hepatic vascular disease 10.1 MMP9 VEGFA
8 senile atrophy of choroid 10.1 MMP9 VEGFA
9 microcephaly 10.1 TLR2 TNF VDR
10 large cell medulloblastoma 10.1 MMP9 VEGFA
11 spotted fever 10.1 TLR2 TNF
12 neonatal hypoxic and ischemic brain injury 10.1 IL6 MMP9
13 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.1 IL6 TNF
14 craniosynostosis, type 1 10.1 IL6 VEGFA
15 demodicidosis 10.1
16 periarthritis 10.1 TLR2 TNF VDR
17 dyslexia 5 10.1 IL6 TNF
18 aortic atherosclerosis 10.0 IL6 TNF
19 stickler syndrome, type v 10.0 IL6 MMP9 VDR
20 fasciitis 10.0 MMP8 TLR2 TNF
21 ulcerative proctitis 10.0 TLR2 TNF VEGFA
22 unilateral multicystic dysplastic kidney 10.0 IL6 TNF
23 thymic neuroendocrine carcinoma 10.0 IL6 TNF
24 vascular dementia 10.0 MMP8 MMP9 TNF
25 swine influenza 10.0 IL6 TNF
26 drug dependence 10.0 IL6 TNF
27 afibrinogenemia 10.0 IL6 VDR
28 conjugate gaze palsy 10.0 IL6 TLR2 VEGFA
29 cardiac tuberculosis 10.0 IL6 VEGFA
30 labyrinthitis 10.0 IL6 TNF VDR
31 pituitary infarct 10.0 IL6 MMP9 VEGFA
32 aortic coarctation 10.0 IL6 TLR2 TNF
33 mixed ductal-endocrine carcinoma 10.0 IL6 MMP8 MMP9
34 crohn's colitis 10.0 IL6 TLR2 TNF
35 histiocytoid hemangioma 10.0 IL6 MMP9 VEGFA
36 autoimmune disease of central nervous system 10.0 IL6 TLR2 TNF
37 inappropriate adh syndrome 10.0 IL6 TLR2 TNF
38 disease of mental health 10.0 IL6 TLR2 TNF
39 atrophy of prostate 10.0 IL6 TLR2 TNF
40 trichomalacia 10.0 IL6 MMP9 TNF
41 mansonelliasis 10.0 IL6 TLR2 TNF
42 hallucinogen dependence 10.0 IL6 TLR2 TNF
43 asbestosis 10.0 IL6 TLR2 TNF
44 keratomalacia 10.0 IL6 TLR2 TNF
45 chordoid meningioma 9.9 IL6 MMP9 TNF
46 splenic marginal zone lymphoma 9.9 IL6 MMP9 TNF
47 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 IL6 TLR2 TNF
48 autosomal recessive type iv ehlers-danlos syndrome 9.9 IL6 MMP8 TNF
49 sclerosing adenosis of breast 9.9 IL6 TLR2 TNF
50 placenta praevia 9.9 MMP9 TNF VEGFA

Graphical network of the top 20 diseases related to Rosacea:



Diseases related to Rosacea

Symptoms & Phenotypes for Rosacea

UMLS symptoms related to Rosacea:


exanthema, pruritus

MGI Mouse Phenotypes related to Rosacea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 IL6 MMP9 PTGDR TLR2 TNF VDR
2 hematopoietic system MP:0005397 9.97 MMP9 PTGDR TLR2 TNF VDR VEGFA
3 immune system MP:0005387 9.97 VEGFA CAMP IL6 MMP8 MMP9 PTGDR
4 digestive/alimentary MP:0005381 9.88 IL6 MMP9 TLR2 TNF VDR VEGFA
5 integument MP:0010771 9.8 IL6 MMP9 PTGDR TLR2 TNF VDR
6 muscle MP:0005369 9.7 IL6 MMP9 PTGDR TLR2 TNF VDR
7 neoplasm MP:0002006 9.43 IL6 MMP8 MMP9 TLR2 TNF VEGFA
8 respiratory system MP:0005388 9.1 IL6 MMP9 PTGDR TLR2 TNF VEGFA

Drugs & Therapeutics for Rosacea

Drugs for Rosacea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
2
Ivermectin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 70288-86-7 6474909 46936176
3
Azelaic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 123-99-9 2266
4
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
5
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Sulfacetamide Approved Phase 4 144-80-9 5320
8
Aminolevulinic acid Approved Phase 4 106-60-5 137
9
Timolol Approved Phase 4,Phase 1 26839-75-8 33624 5478
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Antimalarials Phase 4,Phase 3,Phase 2
13 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2,Early Phase 1
17 Anti-Inflammatory Agents Phase 4,Phase 2
18 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
20 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
21 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
22 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Phase 1 70359-46-5
24 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Antifungal Agents Phase 4
26 Antirheumatic Agents Phase 4,Phase 2,Phase 1
27 Calcineurin Inhibitors Phase 4,Phase 2
28 Immunosuppressive Agents Phase 4,Phase 2
29 Photosensitizing Agents Phase 4
30 Adrenergic Antagonists Phase 4,Phase 1
31 Adrenergic beta-Antagonists Phase 4,Phase 1
32 Anti-Arrhythmia Agents Phase 4,Phase 1
33
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
34
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
35
Ephedrine Approved Phase 3,Phase 1,Phase 2 299-42-3 9294
36
Oxymetazoline Approved Phase 3 1491-59-4 4636
37
Phenylephrine Approved Phase 3 59-42-7 6041
38
Pseudoephedrine Approved Phase 3,Phase 1,Phase 2 90-82-4 7028
39
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
40
Minocycline Approved, Investigational Phase 3,Phase 2,Phase 1 10118-90-8 5281021
41
Tretinoin Approved, Investigational, Nutraceutical Phase 2, Phase 3 302-79-4 5538
42 tannic acid Approved, Nutraceutical Phase 3
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
44 Respiratory System Agents Phase 3,Phase 1,Phase 2
45 Clindamycin palmitate Phase 2, Phase 3
46 Clindamycin phosphate Phase 2, Phase 3
47 Clindamycin, tretinoin drug combination Phase 2, Phase 3
48 Keratolytic Agents Phase 2, Phase 3
49 Autonomic Agents Phase 3,Phase 1,Phase 2
50 Mydriatics Phase 3

Interventional clinical trials:

(show top 50) (show all 130)
id Name Status NCT ID Phase
1 Patient Centered Outcomes in Rosacea: An Exploratory Multi-media Analysis of the Patient Experience on Oracea Completed NCT01872715 Phase 4
2 MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea. Completed NCT02616250 Phase 4
3 Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea Completed NCT00855595 Phase 4
4 Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Completed NCT01308619 Phase 4
5 Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens Completed NCT00495313 Phase 4
6 Efficacy of Topical Cyclosporin for Ocular Rosacea Completed NCT00348335 Phase 4
7 ORCA - Oracea® for Rosacea: A Community-based Assessment Completed NCT00892281 Phase 4
8 Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study Completed NCT02147691 Phase 4
9 A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily Completed NCT00417937 Phase 4
10 Mirvaso in Use Study Completed NCT02249065 Phase 4
11 Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Completed NCT01426269 Phase 4
12 Assess the Ability of MetroGel 1% to Deliver Moisture to Facial Skin After a Single Application Completed NCT00436527 Phase 4
13 Photodynamic Therapy for Papulopustular Rosacea Recruiting NCT02075671 Phase 4
14 Internet Surveys and Their Impact on Adherence to Brimonidine Topical Gel and QOL in Patients With Rosacea Recruiting NCT02659670 Phase 4
15 Topical Brimonidine to Reduce Inflammation After IPL-treatment in Patients With Facial Telangiectasias Recruiting NCT02761174 Phase 4
16 Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea Not yet recruiting NCT03053700 Phase 4
17 Oracea Soolantra Association in Patients With Severe Rosacea Not yet recruiting NCT03075891 Phase 4
18 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4
19 Topical 0.5% Ivermectin Cream for Treatment of Demodicidosis Unknown status NCT02036229 Phase 3
20 Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01318733 Phase 3
21 Azelaic Acid on Demodex Counts in Rosacea Completed NCT03035955 Phase 2, Phase 3
22 Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea Completed NCT01555463 Phase 3
23 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01355458 Phase 3
24 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01355471 Phase 3
25 Determine the Effect of Administering Periostat(R) Twice Daily on Patients With Acne Rosacea Completed NCT00041977 Phase 3
26 Randomized, Double-blind, Multiple-site, Placebo-controlled, Parallel-design Study in Patients With Moderate to Severe Facial Erythema Associated With Rosacea Completed NCT02289352 Phase 3
27 A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea Completed NCT02120924 Phase 3
28 A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea Completed NCT02393937 Phase 3
29 Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea Completed NCT00823901 Phase 2, Phase 3
30 Isotretinoin in Papular-Pustular Rosacea Completed NCT00882531 Phase 3
31 Phase 3 Papulopustular Rosacea Study Completed NCT01494467 Phase 3
32 Phase 3 Papulopustular Rosacea Study Completed NCT01493687 Phase 3
33 A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea Completed NCT00126399 Phase 3
34 CD5024 1% [Ivermectin 1%] Cream Versus Metronidazole 0.75% Cream in Papulopustular Rosacea (PPR) Study Completed NCT01493947 Phase 3
35 Study of 0444 Gel in the Treatment of Inflammatory Lesions of Rosacea Completed NCT01016782 Phase 3
36 A Long-Term Safety and Efficacy Study AGN-19920 in Patients With Persistent Erythema Associated With Rosacea Completed NCT02095158 Phase 3
37 Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea Completed NCT01659853 Phase 3
38 Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea Completed NCT02132117 Phase 3
39 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema of Rosacea Completed NCT01789775 Phase 3
40 Comparative Safety and Efficacy of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea Completed NCT02795117 Phase 3
41 Comparative Safety and Efficacy of Two Rosacea Products in the Treatment of Facial Erythema of Rosacea Completed NCT02385240 Phase 3
42 Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With Rosacea Completed NCT02131636 Phase 3
43 Patient-Reported Outcome Of Facial Erythema (PROOF) Completed NCT01885000 Phase 3
44 Clinical Endpoint Study of Ivermectin 1% Cream Active, not recruiting NCT02840461 Phase 3
45 Bioequivalence Study of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea on the Face Active, not recruiting NCT02800148 Phase 3
46 Study to Evaluate the Long-term Safety of a Once-Daily Omiganan Topical Gel Active, not recruiting NCT02576847 Phase 3
47 Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle Active, not recruiting NCT02576860 Phase 3
48 Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle Active, not recruiting NCT02547441 Phase 3
49 A Study to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam Compared to Vehicle in the Treatment of Facial Papulopustular Rosacea Not yet recruiting NCT03142451 Phase 3
50 Atralin Gel for the Treatment of Rosacea Terminated NCT01125930 Phase 3

Search NIH Clinical Center for Rosacea

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rosacea

Genetic Tests for Rosacea

Anatomical Context for Rosacea

MalaCards organs/tissues related to Rosacea:

39
Skin, Eye, B Cells, Small Intestine, Testes, Endothelial, Neutrophil

Publications for Rosacea

Articles related to Rosacea:

(show top 50) (show all 667)
id Title Authors Year
1
Risk of inflammatory bowel disease in patients with rosacea: Results from a nationwide cohort study in Taiwan. ( 28073582 )
2017
2
The Role of Skin Care in Optimizing Treatment of Acne and Rosacea. ( 28492949 )
2017
3
Development of Papulopustular Rosacea during Nivolumab Therapy of Metastatic Cancer. ( 27826614 )
2016
4
Clinical assessment of rosacea severity: oriental score vs. quantitative assessment method with imaging and biomedical tools. ( 27514310 )
2016
5
Facial Dermatitis and Rosacea. ( 27537212 )
2016
6
Otophyma: a rare variant of phymatous rosacea. ( 27178518 )
2016
7
A Randomized Controlled Trial of Omega 3 Fatty Acids in Rosacea Patients with Dry Eye Symptoms. ( 27050028 )
2016
8
State of the art: systemic rosacea management. ( 27869374 )
2016
9
Physical modalities for the treatment of rosacea. ( 27869377 )
2016
10
Efficacy and safety of permethrin 5% topical gel vs. placebo for rosacea: a double-blind randomized controlled clinical trial. ( 27600257 )
2016
11
Ocular acne rosacea in tertiary eye center in Saudi Arabia. ( 28039671 )
2016
12
Association between rosacea and gastrointestinal disorders. ( 27603953 )
2016
13
The relation of rosacea to insulin resistance and metabolic syndrome. ( 27026639 )
2016
14
A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options. ( 27087407 )
2016
15
Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris. ( 28083023 )
2016
16
Rosacea Management. ( 27843919 )
2016
17
The role of small intestinal bacterial overgrowth in rosacea: A 3-year follow-up. ( 27543234 )
2016
18
Comparative Efficacy of Radiofrequency and Pulsed Dye Laser in the Treatment of Rosacea. ( 27893539 )
2016
19
Granulomatous rosacea-like facial eruption in an elderly man: leukaemia cutis. ( 27118756 )
2016
20
Rosacea Management: Update on general measures and topical treatment options. ( 27869379 )
2016
21
Recalcitrant steroid-induced rosacea successfully treated with 0.03% tacrolimus and 595-nm pulsed dye laser. ( 27193042 )
2016
22
Monitoring structural changes in Demodex mites under topical Ivermectin in rosacea by means of reflectance confocal microscopy: a case series. ( 27976437 )
2016
23
Rosacea fulminans or acute rosacea? Report of 5 cases and review of the literature. ( 27595202 )
2016
24
Idiopathic Facial Aseptic Granuloma in a 13-Year-Old Boy Dramatically Improved with Oral Doxycycline and Topical Metronidazole: Evidence for a Link with Childhood Rosacea. ( 27920676 )
2016
25
Rosacea and gastrointestinal disorders - a population-based cohort study. ( 27501017 )
2016
26
TRPV4 mediates mast cell activation in cathelicidin-induced rosacea inflammation. ( 27908695 )
2016
27
Rosacea: a Clinical Review. ( 27942368 )
2016
28
Treatment of rosacea with topical ivermectin cream: a series of 34 cases. ( 27617938 )
2016
29
Four Diseases, Two Associations, One Patient: A Case of Frontal Fibrosing Alopecia, Lichen Planus Pigmentosus, Acne Rosacea, and Morbihan Disease. ( 27502265 )
2016
30
New developments in the treatment of rosacea - role of once-daily ivermectin cream. ( 27051311 )
2016
31
Azathioprine-induced rosacea. ( 27997728 )
2016
32
Low-Dose Isotretinoin: An OptionA forA Difficult-to-Treat Papulopustular Rosacea. ( 27212646 )
2016
33
Clinical and Histologic Effects of Fractional Microneedling Radiofrequency Treatment on Rosacea. ( 27608206 )
2016
34
Objective severity does not capture the impact of rosacea, acne scarring and photoaging in patients seeking laser therapy. ( 27640402 )
2016
35
Two Consecutive Standardized Skin Surface Biopsies: An Improved Sampling Method to Evaluate Demodex Density as a Diagnostic Tool for Rosacea and Demodicosis. ( 27573185 )
2016
36
Incidental focal epidermolytic hyperkeratosis in rosacea. ( 27401945 )
2016
37
Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. ( 27649161 )
2016
38
A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea. ( 27151386 )
2016
39
Drug-Induced Rosacea-like Dermatitis. ( 27149131 )
2016
40
EGFRI-induced papulopustular rosacea-like rash successfully treated with topical ivermectin. ( 27988991 )
2016
41
Canadian Clinical Practice Guidelines for Rosacea. ( 27207355 )
2016
42
Sensitization to and allergic contact dermatitis caused by Mirvaso(Ar) (brimonidine tartrate) for treatment of rosacea - 2 cases. ( 27133629 )
2016
43
Development of a core outcome set for clinical trials in rosacea: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. ( 27580586 )
2016
44
Pediatric rosacea. ( 27529708 )
2016
45
Ivermectin 1% Cream (Soolantra) for Inflammatory Lesions of Rosacea. ( 27637130 )
2016
46
Combination treatment of propranolol, minocycline, and tranexamic acid for effective control of rosacea. ( 27891741 )
2016
47
Patient-reported outcomes of azelaic acid foam 15% for patients with papulopustular rosacea: secondary efficacy results from a randomized, controlled, double-blind, phase 3 trial. ( 27874885 )
2016
48
Parkinson disease: New evidence for a pathogenic link between rosacea and Parkinson disease. ( 27063106 )
2016
49
Successful treatment of rosacea fulminans in a 59-year-old woman with macrolide antibiotics and prednisone. ( 27028670 )
2016
50
Pathogenesis and clinical presentation of rosacea as a key for a symptom-oriented therapy. ( 27869372 )
2016

Variations for Rosacea

Expression for Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for Rosacea

Pathways related to Rosacea according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.13 IL6 MMP9 TLR2 TNF
2
Show member pathways
12.1 IL6 TLR2 TNF
3 12.07 MMP9 TLR2 TNF VEGFA
4
Show member pathways
12.02 IL6 TLR2 TNF
5 12.01 IL6 TNF VEGFA
6 11.92 MMP9 TNF VEGFA
7 11.85 IL6 MMP9 TNF
8 11.79 IL6 MMP9 TNF
9
Show member pathways
11.78 IL6 TLR2 TNF
10 11.74 IL6 TNF VEGFA
11
Show member pathways
11.73 MMP8 MMP9 TNF
12 11.71 IL6 TLR2 TNF
13 11.68 IL6 MMP9 TNF VEGFA
14 11.61 CAMP IL6 TLR2 TNF VDR
15 11.56 IL6 TLR2 TNF
16 11.51 IL6 TLR2 TNF VEGFA
17 11.5 IL6 MMP9 TNF
18 11.45 MMP9 PTGDR VEGFA
19 11.39 IL6 TLR2 TNF
20 11.3 IL6 TLR2 TNF
21 11.26 IL6 MMP9 TNF
22
Show member pathways
11.26 IL6 MMP9 TNF VEGFA
23 11.24 IL6 MMP9 TLR2 TNF VEGFA
24 11.2 IL6 TNF VDR
25 11.04 MMP9 TLR2
26 11.01 MMP9 VEGFA
27 10.96 IL6 TNF
28 10.89 IL6 TNF
29 10.74 TNF VDR

GO Terms for Rosacea

Cellular components related to Rosacea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CAMP IL6 MMP8 MMP9 TNF VEGFA
2 tertiary granule lumen GO:1904724 8.8 CAMP MMP8 MMP9

Biological processes related to Rosacea according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.97 IL6 TLR2 TNF VDR VEGFA
2 neutrophil degranulation GO:0043312 9.86 CAMP MMP8 MMP9 TLR2
3 inflammatory response GO:0006954 9.73 IL6 PTGDR TLR2 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.72 MMP9 TNF VEGFA
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 IL6 TLR2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.63 CAMP IL6 TNF
7 endodermal cell differentiation GO:0035987 9.59 MMP8 MMP9
8 positive regulation of interleukin-8 production GO:0032757 9.58 TLR2 TNF
9 positive regulation of protein complex assembly GO:0031334 9.57 TNF VEGFA
10 positive regulation of gene expression GO:0010628 9.55 IL6 TLR2 TNF VDR VEGFA
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 TLR2 TNF
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.54 IL6 TNF VEGFA
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.51 MMP9 TNF
14 macrophage differentiation GO:0030225 9.49 MMP9 VEGFA
15 negative regulation of growth of symbiont in host GO:0044130 9.48 CAMP TNF
16 positive regulation of interleukin-6 production GO:0032755 9.43 IL6 TLR2 TNF
17 negative regulation of lipid storage GO:0010888 9.4 IL6 TNF
18 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.32 IL6 TNF
19 positive regulation of chemokine production GO:0032722 9.13 IL6 TLR2 TNF
20 defense response to Gram-positive bacterium GO:0050830 8.92 CAMP IL6 TLR2 TNF

Sources for Rosacea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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