MCID: RSC001
MIFTS: 53

Rosacea malady

Skin category

Summaries for Rosacea

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it most often affects middle-aged and older adults. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin, and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. there is no cure, but treatments can help. they include medicines and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rosacea, also known as acne, erythematosa, is related to atopic dermatitis and basal cell carcinoma. An important gene associated with Rosacea is CAMP (cathelicidin antimicrobial peptide), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The drugs benzoyl peroxide and metronidazole and the compounds bpde and butyrate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, salivary gland and skin.

Wikipedia:64 Rosacea /roʊˈzeɪʃiə/ is a chronic condition characterized by facial erythema (redness) and... more...

Aliases & Classifications for Rosacea

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

rosacea 8 10 34 61
acne, erythematosa 8
acne rosacea 8
rosacea nos 8
acne roscea 8


External Ids:

Disease Ontology8 DOID:8881
MeSH35 D012393
ICD9CM27 695.3
ICD1025 L71, L71.9

Related Diseases for Rosacea

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Rosacea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis30.1ADSL, KLK5
2basal cell carcinoma29.8GSTT1, GSTM1, MMP3
3stomach cancer29.8S100A8, MMP3, KDR, GSTM1, GSTT1, GSTP1
4acne10.8
5granulomatous rosacea10.8
6demodicidosis10.5
7rosacea conjunctivitis10.3
8blepharitis10.2
9granulomatous dermatitis10.1
10keratoconjunctivitis sicca10.1
11occupational dermatitis10.1
12ulcerative colitis10.1
13sporotrichosis10.1
14allergic contact dermatitis10.1
15polyploidy10.1
16nephrotic syndrome10.0CETP
17periodontitis10.0MMP8
18peritonitis10.0MMP8
19duodenitis10.0S100A8
20gingivitis10.0MMP8
21dermatitis10.0IL18
22myeloma10.0MMP8
23periodontal disease10.0MMP3
24sarcoidosis10.0IL18
25pulmonary emphysema10.0MMP8
26hellp syndrome10.0GSTP1
27liver cirrhosis10.0ALPI, CETP
28glaucoma10.0GSTP1
29kawasaki disease10.0MMP3
30pancreatitis10.0GSTP1
31lupus erythematosus10.0IL18
32deficiency anemia10.0GSTM1
33acute pancreatitis10.0IL18
34gastritis10.0S100A8
35funisitis10.0MMP8
36myocardial infarction10.0GSTT1, CETP
37malignant mesothelioma10.0KDR
38cleft palate10.0GSTM1
39essential hypertension10.0NISCH, CETP
40acute myocardial infarction10.0MMP8, GSTM1
41cleft lip10.0GSTM1
42esophagitis10.0S100A8
43sclerosing cholangitis10.0NISCH
44asbestosis10.0GSTT1, GSTM1
45malignant glioma10.0KDR, GSTP1
46diabetes mellitus10.0CETP, MMP3, NISCH
47migraine10.0GSTM1
48brain cancer10.0GSTM1, GSTT1
49motor neuron disease10.0GSTT1
50abdominal aortic aneurysm10.0MMP3, MMP8, CETP

Graphical network of the top 20 diseases related to Rosacea:



Diseases related to rosacea

Clinical Features for Rosacea

Drugs & Therapeutics for Rosacea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Rosacea

Anatomical Context for Rosacea

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Rosacea:

33
Small intestine, Salivary gland, Skin, Myeloid, T cells, B cells, Endothelial

Animal Models for Rosacea or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Rosacea

Sources:
51PubMed
See all sources

Articles related to Rosacea:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 2: a status report on topical agents. (24416742)
2013
2
Polygonal vessels of rosacea are highlighted by dermoscopy. (23879349)
2013
3
Emerging therapies in rosacea. (24229638)
2013
4
Potential role of Demodex mites and bacteria in the induction of rosacea. (22933353)
2012
5
Is it acne or is it rosacea? An important distinction. (22988645)
2012
6
Re. Inflammation in rosacea and acne: implications for patient care. (22303551)
2012
7
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. (22531699)
2012
8
Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea. (22360333)
2012
9
Optimal management of papulopustular rosacea: rationale for combination therapy. (22777226)
2012
10
Pediatric ocular rosacea: 2 cases. (22267454)
2012
11
Clinical presentations and classification of rosacea. (22183098)
2011
12
Laser and intense pulsed light management of couperose and rosacea. (22183103)
2011
13
Self-reported treatment impressions and satisfaction of papulopustular rosacea patients treated with doxycycline, USP, 40 mg capsules. (22134561)
2011
14
Interventions for rosacea. (21412882)
2011
15
Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. (20586834)
2011
16
A rare case of vulval pustulation in rosacea fulminans. (20456399)
2010
17
Persistent eyelid swelling in a patient with rosacea. (19266745)
2009
18
Granulomatous rosacea in Cornelia de Lange syndrome. (19172039)
2009
19
Current topical and systemic approaches to treatment of rosacea. (19508315)
2009
20
Topical PRK 124 (0.125%) lotion for improving the signs and symptoms of rosacea. (19537369)
2009
21
Intestinal alkaline phosphatase: the molecular link between rosacea and gastrointestinal disease? (19573995)
2009
22
Severe exacerbation of rosacea induced by cinnamon supplements. (18561592)
2008
23
Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea. (18561589)
2008
24
Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. (18254805)
2008
25
Granulomatous rosacea and Crohn's disease in a patient homozygous for the Crohn-associated NOD2/CARD15 polymorphism R702W. (18616576)
2008
26
Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial. (17493072)
2007
27
An open-label pilot study to evaluate the safety and efficacy of topically applied pimecrolimus cream for the treatment of steroid-induced rosacea-like eruption. (17373975)
2007
28
The role of Chlamydia pneumoniae in the etiology of acne rosacea: response to the use of oral azithromycin. (17388221)
2007
29
Rosacea trial comparing twice-daily azelaic acid gel 15% with once-daily metronidazole gel 1%. (17330623)
2007
30
The effect of azithromycin on reactive oxygen species in rosacea. (17244346)
2007
31
Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. (17367893)
2007
32
Wegener's granulomatosis presenting with granulomatous facial erythematous papules and plaques mimicking granulomatous rosacea. (16792787)
2006
33
An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. (17173568)
2006
34
Rosacea fulminans in pregnancy: case report and review of the literature. (16605294)
2006
35
Laser and light therapies for acne rosacea. (16468290)
2006
36
Childhood stye and adult rosacea. (17097390)
2006
37
Dendritic keratopathy in ocular rosacea. (15968176)
2005
38
Drugs for acne, rosacea and psoriasis. (15961971)
2005
39
Granulomatous rosacea mimicking eyelid dermatitis. (16394471)
2005
40
The rigor of trials evaluating Rosacea treatments. (15810805)
2005
41
Has Helicobacter pylori eradication therapy any effect on severity of rosacea symptoms? (15857486)
2005
42
Face up to rosacea. (16151303)
2005
43
Rosacea, acne rosacea, and actinic telangiectasia. (15761448)
2005
44
Rosacea, acne rosacea, and actinic telangiectasia: in reply. (16310093)
2005
45
Rosacea. An overview of diagnosis and management. (15615217)
2004
46
Topical treatment for the inflamed lesion in acne, rosacea, and pseudofolliculitis barbae. (15228127)
2004
47
Ocular rosacea can mimic trachoma: a case of cicatrizing conjunctivitis. (15257004)
2004
48
Kaposi's varicelliform eruption in association with rosacea. (15577762)
2004
49
The role of free oxygen radicals in the aetiopathogenesis of rosacea. (12653711)
2003
50
Cutaneous lymphoplasmacytoid lymphoma (immunocytoma) with WaldenstrAPm's macroglobulinemia mimicking rosacea. (14639408)
2003

Genetic Variations for Rosacea

Expression for genes affiliated with Rosacea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for genes affiliated with Rosacea

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Rosacea

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Rosacea according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1bpde4510.7GSTP1
2butyrate4510.5ALPI, CAMP
3(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1110.4GSTM1, GSTP1
4dcnb4510.4GSTP1, GSTM1
5n-(2-hydroxyethyl)valine4510.4GSTM1, GSTT1
6methylchloride4510.4GSTT1, GSTM1, GSTP1
7drugs for treatment of tuberculosis5010.4GSTM1, GSTT1
8s-phenylmercapturic acid4510.4GSTP1, GSTM1, GSTT1
91,3-butadiene4510.4GSTM1, GSTT1, GSTP1
10cumene hydroperoxide4510.4GSTP1, GSTM1, GSTT1
111-hydroxypyrene4510.4GSTP1, GSTT1, GSTM1
12styrene4510.4GSTM1, GSTT1, GSTP1
13trichloroethylene4510.3GSTP1, GSTT1, GSTM1
14noradrenochrome45 2411.3GSTP1, GSTM1, GSTT1
15marimastat45 60 1112.3MMP3, MMP8, KDR
16hydrochloric acid45 2411.3GSTP1, GSTT1, GSTM1
17adrenochrome45 2411.3GSTP1, GSTT1, GSTM1
18alendronate45 50 1112.2MMP8, MMP3, IL18
19acetone4510.2GSTP1, GSTT1, GSTM1
20hydrocarbons4510.2GSTP1, GSTT1, GSTM1
211-chloro-24-dinitrobenzene4510.2IL18, GSTP1, GSTT1, GSTM1
228-oxo-dg4510.2GSTM1, S100A8, GSTT1
23mspi4510.2CETP, GSTT1, GSTM1
24cyclophosphamide45 50 1112.2GSTT1, GSTP1, GSTM1, KDR
25carboplatin45 50 1112.1GSTM1, KDR, GSTT1, GSTP1
26chi 24510.1GSTM1, GSTT1, IL18, S100A8
27allergens4510.1SCP2, IL18, CETP, S100A8
282,4,6-trinitrotoluene4510.1GSTM1, GSTP1
29p0024510.1MMP3, MMP8, IL18, GSTT1, GSTM1
30gsts4510.0GSTT1, GSTP1, GSTM1
31urea45 11 2412.0ADSL, MMP8, MMP3, S100A8
32trans,trans-muconic acid4510.0GSTT1, GSTM1
33simvastatin45 50 60 29 11 2415.0CETP, IL18, MMP3, KDR
34folate4510.0GSTT1, KDR, IL18, GSTP1, GSTM1
35ifosfamide45 1111.0GSTT1, GSTM1, GSTP1
36ascorbic acid45 2411.0GSTT1, GSTP1, GSTM1, CETP, MMP3
37valine4510.0GSTT1, GSTM1, GSTP1, CETP, ILVBL
38Glutathione11 2410.9GSTP1, GSTT1, GSTM1
39methotrexate45 50 1111.9S100A8, IL18, MMP3, GSTM1, GSTP1
40lactate459.8GSTM1, GSTP1, MMP8, IL18, KDR, MMP3
41doxorubicin45 50 1111.8GSTT1, GSTP1, IL18, GSTM1, KDR
42arginine459.7KDR, NISCH, GSTT1, IL18, GSTM1, GSTP1
43serine459.6KLK5, CAMP, S100A8, IL18, MMP3, CETP
44estrogen459.6CAMP, IL18, MMP3, KDR, CETP, GSTM1
45cholesterol45 29 11 2412.6SCP2, IL18, MMP3, CETP, S100A8, CAMP
46retinoic acid45 2410.5IL18, S100A8, CAMP, MMP3, MMP8, KDR
47cysteine459.4GSTM1, GSTP1, KDR, MMP8, MMP3, CETP
48creatinine459.4GSTT1, S100A8, ADSL, IL18, MMP3, ALPI
49genistein45 29 60 2 11 2414.4GSTP1, KDR, MMP3, MMP8, CAMP
50lipid459.2MMP3, IL18, CETP, MMP8, GSTT1, ALPI

GO Terms for genes affiliated with Rosacea

Sources:
16Gene Ontology
See all sources

Cellular components related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4CETP, MMP8, MMP3, IL18, S100A8, KLK5
2extracellular regionGO:0055768.8CETP, KLK5, CAMP, S100A8, IL18, MMP3

Biological processes related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid transportGO:01591410.2CETP, SCP2
2glutathione derivative biosynthetic processGO:19016879.9GSTP1, GSTT1, GSTM1
3glutathione metabolic processGO:0067499.8GSTM1, GSTT1, GSTP1
4positive regulation of superoxide anion generationGO:0329309.8GSTP1, IL18

Molecular functions related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.9GSTP1, GSTT1, GSTM1

Products for genes affiliated with Rosacea

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rosacea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet