Rosacea malady

MedlinePlus: Rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it usually starts between age 30 and 60. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. it can be treated with medications and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Rosacea, also known as acne rosacea (disorder), is related to polycystic ovary syndrome and periodontitis. An important gene associated with Rosacea is SMNDC1 (survival motor neuron domain containing 1), and among its related pathways are Development VEGF-family signaling and MSP-RON Signaling. The drugs benzoyl peroxide and metronidazole hydrochloride and the compounds egcg and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotype immune system.

Wikipedia: Rosacea /roʊˈzeɪʃiə/ is a chronic condition characterized by facial erythema (redness) and...⁴⁴ more...

Aliases & Descriptions:

rosacea 6 8 23 43 acne rosacea (disorder) 6 rosacea nos (disorder) 6 rosacea (disorder) 6

acne, erythematosa 6 acne roscea 6 acne 43

Diseases related to rosacea by text searches and GeneDecks gene sharing:

(show top 50)    (show all 396)

id	Related Disease	Score	Top Affiliating Genes
1	polycystic ovary syndrome	26.7	VEGFA, VDR, CGA, CETP, FLT1, IL18
2	periodontitis	26.2	VDR, MMP8, IL8, TLR2
3	squamous cell carcinoma	25.4	VEGFA, KDR, S100A8, GSTM1, GSTP1, GSTT1
4	acne	25.4	IL18, IL8, CAMP, EGF, TLR2, SOD1
5	squamous cell carcinoma of the head and neck	24.4	VEGFA, KDR, FLT1, GSTM1, GSTP1, GSTT1
6	homocysteine	23.9	VEGFA, CETP, GSTM1, GSTP1, GSTT1, IL18
7	sinusitis	23.7	VEGFA, CGA, GSTP1, IL8, CAMP, TLR2
8	blindness	23.6	VEGFA, VDR, KDR, CGA, CETP, IL18
9	insulin resistance	21.7	VEGFA, VDR, KDR, SCP2, CGA, CETP
10	sarcoidosis	21.7	VEGFA, VDR, KDR, S100A8, MMP8, FLT1
11	arthritis	21.4	VEGFA, VDR, KDR, S100A8, MMP8, FLT1
12	dermatitis	21.1	VEGFA, S100A8, GSTM1, GSTP1, GSTT1, IL18
13	obesity	20.3	VEGFA, VDR, S100A8, CGA, CETP, MMP8
14	carcinoma	19.7	VEGFA, VDR, KDR, SCP2, S100A8, CGA
15	food allergy	13.4	SCP2, S100A8, CETP
16	duodenal disease	13.3	S100A8, TLR2
17	arteriovenous malformation	13.1	KDR, FLT1
18	oral submucous fibrosis	13.0	MMP8, GSTM1, GSTT1
19	diffuse gastric cancer	13.0	GSTM1, GSTP1, GSTT1
20	lepromatous leprosy	13.0	VDR, IL18, TLR2
21	cardia cancer	13.0	GSTM1, GSTP1, GSTT1
22	mycobacterial infection	13.0	IL18, CAMP, TLR2
23	bladder cancer susceptibility	12.9	GSTM1, GSTP1, GSTT1
24	microcystic meningioma	12.9	VEGFA, FLT1
25	asbestosis	12.9	GSTM1, GSTP1, GSTT1
26	skin carcinoma	12.9	GSTM1, GSTP1, GSTT1
27	alcoholic pancreatitis	12.9	GSTM1, GSTP1, GSTT1
28	ulceration of vulva	12.9	S100A8, MMP8, CAMP, EGF
29	esophageal atresia	12.9	GSTM1, GSTP1, GSTT1
30	pulmonary tuberculosis	12.9	VDR, IL18, TLR2
31	pulmonary plasma cell granuloma	12.8	S100A8, IL18, TLR2
32	peripheral vascular disease	12.8	VEGFA, CETP, IL18
33	gastritis	12.8	S100A8, GSTT1, IL8
34	corneal neovascularization	12.8	VEGFA, KDR, FLT1
35	lynch syndrome	12.8	GSTM1, GSTP1, GSTT1
36	placental insufficiency	12.8	CGA, FLT1, IL8
37	bacterial meningitis	12.7	MMP8, IL8, TLR2
38	familial prostate cancer	12.7	VDR, GSTM1, GSTP1, GSTT1
39	hemangioendothelioma	12.7	VEGFA, KDR, FLT1
40	osteomalacia	12.7	VDR, GSTM1, GSTP1, GSTT1
41	intrauterine infections	12.7	MMP8, IL8, EGF
42	periostitis	12.6	VEGFA, KDR, FLT1
43	spondylarthropathy	12.6	S100A8, IL8, TLR2
44	hemangioblastoma	12.6	VEGFA, KDR, FLT1
45	rheumatoid arthritis, association with	12.5	VDR, GSTM1, IL18, IL8
46	albinism	12.5	GSTM1, GSTP1, GSTT1, SLC24A4
47	ectopic pregnancy	12.5	VEGFA, CGA, FLT1, TLR2
48	cholesteatoma	12.5	VEGFA, S100A8, MMP8, EGF
49	bacterial vaginosis	12.5	MMP8, FLT1, IL8, TLR2
50	reactive arthritis	12.5	MMP8, IL18, IL8, TLR2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 azelaic acid, benzoyl peroxide, loteprednol, loteprednol etabonate, metronidazole, metronidazole hydrochloride, metronidazole pwdr [va product], resorcinol, resorcinol pwdr [va product], sulfur, sulfur pwdr [va product], sulfur,colloidal, sulfur,precipitated

MalaCards organs/tissues related to rosacea:

²²

MGI Mouse Phenotypes related to rosacea:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.9	VDR, KDR, SCP2, MMP8, FLT1, CAMP

Articles related to rosacea:

(show all 17)

id	Title	Authors	Year	Affiliating Genes
1	TLR2 expression is increased in rosacea and stimulate s enhanced serine protease production by keratinocytes. (21107351)	Yamasaki K.... Gallo R.L.	2011	TLR2
2	Intestinal alkaline phosphatase: the molecular link b etween rosacea and gastrointestinal disease? (19573995)	Whitehead J.	2009	ALPI
3	Concentration of selected cytokines in serum of patients with acne rosacea (19140384)	Salamon M.... Wozniacka A.	2008	IL18
4	Rosacea fulminans in the early course of a pregnancy by in vitro fertilization with embryo transfer (18929918)	Cisse M.... Machet L.	2008	CGA
5	Expression of vascular endothelial growth factor and its receptors in rosacea. (17244661)	Smith J.R.... Rosenbaum J.T.	2007	FLT1, KDR, VEGFA
6	Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. (17676051)	Yamasaki K.... Gallo R.L.	2007	CAMP
7	GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea. (16869871)	Yazici A.C.... Adiguzel A.	2006	GSTP1, GSTT1, GSTM1
8	Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline. (16411105)	Maatta M.... Sorsa T.	2006	MMP8
9	BsmI polymorphism of the vitamin D receptor gene in patients with the fulminant course of rosacea conglobata (rosacea fulminans). (15187348)	Jansen T.... Messer G.	2004	VDR
10	Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. (14989398)	Asero R.... Amato S.	2004	CETP
11	The role of free oxygen radicals in the aetiopathogenesis of rosacea. (12653711)	Oztas M.O.... Ozer N.	2003	SOD1
12	Allergy to nonspecific lipid transfer proteins in Rosaceae: a comparative study of different in vivo diagnostic methods. (11476467)	Asero R.... Falagiani P.	2001	SCP2, CETP
13	Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. (10998016)	DA-az-Perales A.... Salcedo G.	2000	CETP
14	Helicobacter pylori and its eradication in rosacea. (10695558)	Szlachcic A.... Konturek S.J.	1999	IL8, S100A8
15	Detection and clinical characterization of patients w ith oral allergy syndrome caused by stable allergens in Rosaceae and nuts. (10582717)	Asero R.	1999	CETP
16	Rilmenidine in rosacea: a double-blind study versus placebo (9740864)	Grosshans E.... Cribier B.	1997	NISCH
17	Inflammatory cytokines in the tears of patients with ocular rosacea. (9373119)	Barton K.... Pflugfelder S.C.	1997	EGF

Genes related to rosacea according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	SMNDC1	survival motor neuron domain containing 1	11.0
2	ILVBL	ilvB (bacterial acetolactate synthase)-like	11.0
3	ALPI	alkaline phosphatase, intestinal	11.0	Publications
4	OR6C2	olfactory receptor, family 6, subfamily C, member 2	11.0	Disorders
5	NISCH	nischarin	11.0	Publications
6	KLK5	kallikrein-related peptidase 5	11.0
7	ADSL	adenylosuccinate lyase	11.0
8	CAMP	cathelicidin antimicrobial peptide	11.0	Publications
9	MPHOSPH9	M-phase phosphoprotein 9	11.0
10	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
11	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
12	SCP2	sterol carrier protein 2	11.0	Publications
13	LRWD1	leucine-rich repeats and WD repeat domain containing 1	11.0	Disorders
14	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	11.0
15	S100A8	S100 calcium binding protein A8	11.0	Publications
16	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
17	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
18	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
19	GSTM1	glutathione S-transferase mu 1	11.0	Publications
20	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
21	TLR2	toll-like receptor 2	11.0	Publications
22	GSTP1	glutathione S-transferase pi 1	11.0	Publications
23	GSTT1	glutathione S-transferase theta 1	11.0	Publications
24	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
25	IL8	interleukin 8	11.0	Publications
26	SOD1	superoxide dismutase 1, soluble	11.0	Publications
27	EGF	epidermal growth factor	11.0	Publications
28	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to rosacea according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Development VEGF-family signaling10	9.8	KDR, FLT1
2	MSP-RON Signaling36	9.8	TLR2, KLK5, IL18
3	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.7	VDR, GSTP1, GSTT1
4	Naphthalene metabolism41	9.6	GSTT1, GSTP1, GSTM1
5	Naphthalene metabolism10	9.6	GSTT1, GSTP1, GSTM1
6	Glutathione metabolism10	9.6	GSTM1, GSTP1, GSTT1
7	Neurophilin interactions with VEGF and VEGFR38	9.5	VEGFA, KDR, FLT1
8	Glutathione metabolism20	9.4	GSTM1, GSTP1, GSTT1
9	Development_VEGF-family signaling41	9.3	VEGFA, KDR, FLT1
10	Malaria20	9.2	IL18, IL8, TLR2
11	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.1	GSTM1, GSTP1, GSTT1, SOD1
12	Transcription_P53 signaling pathway41	8.9	FLT1, KDR, VEGFA
13	Rheumatoid arthritis20	8.8	TLR2, IL8, IL18, FLT1, VEGFA
14	Bladder cancer20	8.8	EGF, IL8, VEGFA
15	TGF-Beta Pathway36	8.3	EGF, IL8, IL18, FLT1, KDR
16	MAPK Family Pathway36	8.1	KDR, FLT1, IL18, IL8, EGF
17	Cytokine-cytokine receptor interaction20	7.8	EGF, IL8, IL18, FLT1, KDR, VEGFA

Compounds related to rosacea according to GeneDecks:

(show top 50)    (show all 140)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.3	SOD1
2	h2o232	10.2	CGA, MMP8, IL18
3	hcec32	10.1	TLR2, KDR
4	methylchloride32	9.8	GSTP1, GSTM1, GSTT1
5	s-phenylmercapturic acid32	9.7	GSTT1, GSTM1, GSTP1
6	chi 232	9.7	GSTM1, S100A8, GSTT1, IL18
7	cumene hydroperoxide32	9.6	GSTT1, GSTM1, GSTP1
8	1,3-butadiene32	9.6	GSTT1, GSTM1, GSTP1
9	axitinib32 42	10.5	VEGFA, FLT1, KDR
10	1-chloro-24-dinitrobenzene32	9.5	GSTM1, GSTP1, IL18, GSTT1
11	su 541642	9.5	FLT1, KDR, VEGFA
12	ptk78732	9.5	FLT1, VEGFA, KDR
13	n acetylcysteine32	9.5	IL18, KDR
14	flagellin32	9.4	IL18, S100A8, TLR2, IL8
15	lipoteichoic acid32	9.4	TLR2, CAMP, IL8, IL18
16	ifosfamide32 9 9	11.3	GSTT1, GSTP1, CGA, GSTM1
17	8-oxo-dg32	9.3	GSTT1, S100A8, GSTM1, SOD1
18	ascorbic acid32 18	10.2	VDR, GSTM1, GSTT1, CGA, GSTP1
19	adrenochrome32 18	10.1	SOD1, GSTT1, GSTP1, GSTM1
20	vegf32	9.1	KDR, CAMP, GSTP1, FLT1, MMP8, CGA
21	p00232	9.1	FLT1, MMP8, GSTM1, GSTT1, IL18
22	vitamin a32 9 18 9	12.1	SOD1, ALPI, GSTM1, CETP, VDR, CGA
23	glutathion32	9.1	GSTP1, SOD1, GSTM1
24	pge232	9.1	CAMP, MMP8, CGA, EGF, TLR2
25	heparin32 9 18 9	12.0	CETP, FLT1, CAMP, EGF, CGA
26	zd647432	8.8	FLT1, EGF, VEGFA, KDR
27	folate32	8.6	IL18, VDR, GSTT1, GSTP1, CGA, KDR
28	simvastatin32 34 42 9 18 9	13.5	IL8, IL18, KDR, CETP, VEGFA, TLR2
29	prostacyclin32	8.4	VEGFA, SOD1, CAMP, FLT1, CGA, KDR
30	arginine32	8.4	NISCH, SOD1, IL18, GSTT1, CETP, CGA
31	cyclosporin a32 42	9.3	CGA, CETP, VDR, TLR2, MMP8, KDR
32	cysteine32	8.3	S100A8, KDR, GSTP1, VDR, MMP8, EGF
33	butyrate32	8.3	VDR, GSTP1, IL18, IL8, ALPI, CAMP
34	5fluorouracil32	7.9	VDR, EGF, KDR, GSTP1, IL18, VEGFA
35	alanine32	7.8	CETP, S100A8, CGA, VDR, MMP8, IL18
36	lactate32	7.8	SOD1, IL18, IL8, GSTM1, GSTP1, MMP8
37	sb 20358032 42	8.8	FLT1, EGF, IL8, IL18, VEGFA, VDR
38	testosterone32 9 18 9	10.8	VDR, IL18, CETP, EGF, GSTP1, GSTM1
39	matrigel32	7.6	FLT1, IL18, IL8, EGF, KDR, VEGFA
40	actinomycin d32	7.6	GSTP1, CAMP, EGF, TLR2, CGA, VEGFA
41	lipid32	7.6	IL18, CETP, S100A8, SOD1, TLR2, MMP8
42	nitric oxide32 9 18 9	10.5	TLR2, KDR, S100A8, MMP8, FLT1, CAMP
43	creatinine32	7.5	CGA, ALPI, IL18, GSTT1, GSTP1, GSTM1
44	cisplatin32 34 9 9	10.4	VEGFA, KDR, CGA, FLT1, IL18, EGF
45	retinoic acid32 42 18	9.4	TLR2, CAMP, GSTP1, IL18, EGF, S100A8
46	genistein32 9 18 9	10.3	MMP8, CAMP, EGF, VEGFA, GSTP1, VDR
47	dexamethasone32 42 34 9 9	11.2	TLR2, EGF, VEGFA, VDR, KDR, S100A8
48	doxorubicin32 34 9 9	10.2	CGA, KDR, VEGFA, FLT1, GSTM1, GSTP1
49	estrogen32	6.5	VEGFA, KDR, VDR, GSTM1, CGA, IL18
50	serine32	6.3	KDR, IL18, EGF, VDR, S100A8, CGA

Cellular components related to rosacea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.3	VEGFA, SOD1, EGF, KLK5, IL8, IL18
2	extracellular region	GO:005576	6.2	EGF, KLK5, CAMP, IL8, IL18, MMP8

Biological processes related to rosacea according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of superoxide anion generation	GO:032930	9.9	GSTP1, IL18
2	positive regulation of vascular permeability	GO:043117	9.7	VEGFA, IL18
3	cellular response to vascular endothelial growth factor stimulus	GO:035924	9.4	VEGFA, KDR, FLT1
4	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.4	FLT1, KDR, VEGFA
5	positive regulation of leukocyte migration	GO:002687	9.3	VEGFA, TLR2
6	glutathione metabolic process	GO:006749	9.2	SOD1, GSTT1, GSTP1
7	response to hypoxia	GO:001666	9.2	VEGFA, FLT1, IL18, ADSL
8	positive regulation of cell migration	GO:030335	9.1	VEGFA, KDR, CGA, FLT1
9	positive regulation of MAP kinase activity	GO:043406	8.9	VEGFA, FLT1, EGF
10	peptidyl-tyrosine phosphorylation	GO:018108	8.8	EGF, FLT1, KDR
11	angiogenesis	GO:001525	8.1	VEGFA, KDR, IL18, IL8, EGF

Molecular functions related to rosacea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione transferase activity	GO:004364	9.4	GSTM1, GSTP1, GSTT1