MCID: RSC001
MIFTS: 57

Rosacea malady

Skin diseases category

Summaries for Rosacea

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it most often affects middle-aged and older adults. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin, and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. there is no cure, but treatments can help. they include medicines and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rosacea, also known as acne, erythematosa, is related to dermatitis and psoriasis. An important gene associated with Rosacea is CAMP (cathelicidin antimicrobial peptide), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Aflatoxin B1 metabolism. The drugs benzoyl peroxide and metronidazole and the compounds bpde and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and small intestine.

Wikipedia:63 Rosacea /roʊˈzeɪʃiə/ is a chronic condition characterized by facial erythema (redness) and... more...

Aliases & Classifications for Rosacea

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

rosacea 8 10 33 60
acne, erythematosa 8
acne rosacea 8
rosacea nos 8
acne roscea 8


External Ids:

Disease Ontology8 DOID:8881
MeSH34 D012393
ICD9CM27 695.3
ICD1025 L71, L71.9

Related Diseases for Rosacea

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rosacea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.7IL18
2psoriasis30.3CAMP, S100A8, IL18, KDR, ADSL
3leukemia30.1S100A8, KDR, GSTM1, GSTT1, GSTP1
4atopic dermatitis30.0ADSL, KLK5
5lupus erythematosus29.8IL18
6migraine29.8GSTM1
7pneumonia29.8GSTM1, MMP8, S100A8
8basal cell carcinoma29.8GSTT1, GSTM1, MMP3
9inflammatory bowel disease29.8S100A8, IL18, MMP3, ALPI
10stomach cancer29.8S100A8, MMP3, KDR, GSTM1, GSTT1, GSTP1
11acne10.8
12granulomatous rosacea10.5
13skin disease10.3
14rosacea conjunctivitis10.2
15contact dermatitis10.2
16blepharitis10.2
17granulomatous dermatitis10.1
18eye disease10.1
19keratitis10.1
20keratoconjunctivitis10.1
21crohn's disease10.0
22keratoconjunctivitis sicca10.0
23occupational dermatitis10.0
24wegener's granulomatosis10.0
25ulcerative colitis10.0
26sporotrichosis10.0
27allergic contact dermatitis10.0
28conjunctivitis10.0
29pyoderma10.0
30nephrotic syndrome10.0CETP
31periodontitis10.0MMP8
32peritonitis10.0MMP8
33duodenitis10.0S100A8
34gingivitis10.0MMP8
35myeloma10.0MMP8
36periodontal disease10.0MMP3
37sarcoidosis10.0IL18
38pulmonary emphysema10.0MMP8
39hellp syndrome10.0GSTP1
40liver cirrhosis10.0ALPI, CETP
41glaucoma10.0GSTP1
42kawasaki disease10.0MMP3
43pancreatitis10.0GSTP1
44deficiency anemia10.0GSTM1
45acute pancreatitis10.0IL18
46gastritis10.0S100A8
47funisitis10.0MMP8
48myocardial infarction10.0GSTT1, CETP
49malignant mesothelioma10.0KDR
50cleft palate10.0GSTM1

Graphical network of the top 20 diseases related to Rosacea:



Diseases related to rosacea

Clinical Features for Rosacea

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Drugs & Therapeutics for Rosacea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Rosacea

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Anatomical Context for Rosacea

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rosacea:

32
Skin, Eye, Small intestine, B cells, Endothelial, Salivary gland, Testes, Myeloid

Animal Models for Rosacea or affiliated genes

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Publications for Rosacea

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Sources:
50PubMed
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Articles related to Rosacea:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Antihypertensive drugs and the risk of incident rosacea. (24428524)
2014
2
Long-term safety and efficacy of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1-year open-label study. (24385120)
2014
3
Management of facial erythema of rosacea: what is the role of topical I+-adrenergic receptor agonist therapy? (24229637)
2013
4
The association between psychiatric diseases, psychotropic drugs and the risk of incident rosacea. (24236423)
2013
5
Toll-like receptors and vascular markers in ocular rosacea. (23839635)
2013
6
Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. (23602178)
2013
7
The evolving view of rosacea. (24229631)
2013
8
Characterization of novel O-glycans isolated from tear and saliva of ocular rosacea patients. (23294139)
2013
9
Rosacea. (22727268)
2012
10
Crowdsourcing for research data collection in rosacea. (22483526)
2012
11
Blushing in rosacea sufferers. (22281458)
2012
12
The study of prevalence of Helicobacter pylori in patients with acne rosacea. (23575053)
2012
13
Neurogenic rosacea treated with endoscopic thoracic sympathectomy. (22351842)
2012
14
Evaluation of the efficacy and tolerance of a topical gel with 4% quassia extract in the treatment of rosacea. (21343346)
2012
15
Endothelial and axon reflex vasodilatation to acetylcholine in rosacea-affected skin. (21968600)
2012
16
Facial redness and rosacea... (22183094)
2011
17
Epidermal proteases in the pathogenesis of rosacea. (22076323)
2011
18
Transmission of rosacea from the graft in facial allotransplantation. (21443678)
2011
19
Rosacea (erythematotelangiectatic type) effectively improved by topical xylometazoline. (21352348)
2011
20
Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3. (21980800)
2011
21
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. (21107351)
2011
22
Prevalence analysis of smoking in rosacea. (21812830)
2011
23
A Guide to the Ingredients and Potential Benefits of Over-the-Counter Cleansers and Moisturizers for Rosacea Patients. (21909456)
2011
24
Fibrosing blepharo-conjunctivitis following pyogenic granuloma in ocular acne rosacea. (20735292)
2010
25
A pilot study in discrepancies in quality of life among three cutaneous types of rosacea. (20466185)
2010
26
Rosacea and its topical management. (19330270)
2009
27
The molecular pathology of rosacea. (19481425)
2009
28
Quality of life and rosacea: pulsed dye laser impact. (19462330)
2009
29
Anti-inflamatory dose doxycycline in the treatment of rosacea. (19588643)
2009
30
Rosacea: a review. (19562004)
2009
31
Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea. (18561584)
2008
32
Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial. (18363758)
2008
33
Comprehensive medical management of rosacea: an interim study report and literature review. (21103305)
2008
34
Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results. (18565174)
2008
35
Recalcitrant papulopustular rosacea in an immunocompetent patient responding to combination therapy with oral ivermectin and topical permethrin. (17944176)
2007
36
Recalcitrant rosacea successfully treated with multiplexed pulsed dye laser. (17763618)
2007
37
Living with rosacea. (17626507)
2007
38
Expression of vascular endothelial growth factor and its receptors in rosacea. (17244661)
2007
39
GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea. (16869871)
2006
40
An oedematous lesion in the nasolabial fold. Diagnosis: phymatous lesion with underlying rosacea. (16901327)
2006
41
Group IIA phospholipase A(2) concentration of tears in patients with ocular rosacea. (16029275)
2005
42
Adjunctive skin care in the management of rosacea: cleansers, moisturizers, and photoprotectants. (15810806)
2005
43
A basal cell carcinoma mimicking a sign of rosacea. (16015077)
2005
44
A topical azithromycin preparation for the treatment of acne vulgaris and rosacea. (15370397)
2004
45
Noxious sensory perceptions in patients with mild to moderate rosacea treated with azelaic acid 15% gel. (15551720)
2004
46
Laser treatment of rosacea: a pathoetiological study. (15545543)
2004
47
Pulsed dye laser treatment of rosacea improves erythema, symptomatology, and quality of life. (15389196)
2004
48
Rosacea-like demodicidosis in an immunocompromised child. (12558842)
2003
49
Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole. (11692067)
2001
50
Perioral dermatitis with histopathologic features of granulomatous rosacea: successful treatment with isotretinoin. (2148143)
1990

Genetic Variations for Rosacea

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Expression for genes affiliated with Rosacea

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for genes affiliated with Rosacea

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Rosacea

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Rosacea according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1bpde4410.7GSTP1
2butyrate4410.5ALPI, CAMP
3(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1110.4GSTM1, GSTP1
4dcnb4410.4GSTP1, GSTM1
5n-(2-hydroxyethyl)valine4410.4GSTM1, GSTT1
6methylchloride4410.4GSTT1, GSTM1, GSTP1
7drugs for treatment of tuberculosis4910.4GSTM1, GSTT1
8s-phenylmercapturic acid4410.4GSTP1, GSTM1, GSTT1
91,3-butadiene4410.4GSTM1, GSTT1, GSTP1
10cumene hydroperoxide4410.4GSTP1, GSTM1, GSTT1
111-hydroxypyrene4410.4GSTP1, GSTT1, GSTM1
12styrene4410.4GSTM1, GSTT1, GSTP1
13trichloroethylene4410.3GSTP1, GSTT1, GSTM1
14noradrenochrome44 2411.3GSTP1, GSTM1, GSTT1
15marimastat44 59 1112.3MMP3, MMP8, KDR
16hydrochloric acid44 2411.3GSTP1, GSTT1, GSTM1
17adrenochrome44 2411.3GSTP1, GSTT1, GSTM1
18alendronate44 49 1112.2MMP8, MMP3, IL18
19acetone4410.2GSTP1, GSTT1, GSTM1
20hydrocarbons4410.2GSTP1, GSTT1, GSTM1
211-chloro-24-dinitrobenzene4410.2IL18, GSTP1, GSTT1, GSTM1
228-oxo-dg4410.2GSTM1, S100A8, GSTT1
23mspi4410.2CETP, GSTT1, GSTM1
24cyclophosphamide44 49 1112.2GSTT1, GSTP1, GSTM1, KDR
25carboplatin44 49 1112.1GSTM1, KDR, GSTT1, GSTP1
26chi 24410.1GSTM1, GSTT1, IL18, S100A8
27allergens4410.1SCP2, IL18, CETP, S100A8
282,4,6-trinitrotoluene4410.1GSTM1, GSTP1
29p0024410.1MMP3, MMP8, IL18, GSTT1, GSTM1
30gsts4410.0GSTT1, GSTP1, GSTM1
31urea44 11 2412.0ADSL, MMP8, MMP3, S100A8
32trans,trans-muconic acid4410.0GSTT1, GSTM1
33simvastatin44 49 59 28 11 2415.0CETP, IL18, MMP3, KDR
34folate4410.0GSTT1, KDR, IL18, GSTP1, GSTM1
35ifosfamide44 1111.0GSTT1, GSTM1, GSTP1
36ascorbic acid44 2411.0GSTT1, GSTP1, GSTM1, CETP, MMP3
37valine4410.0GSTT1, GSTM1, GSTP1, CETP, ILVBL
38Glutathione11 2410.9GSTP1, GSTT1, GSTM1
39methotrexate44 49 1111.9S100A8, IL18, MMP3, GSTM1, GSTP1
40lactate449.8GSTM1, GSTP1, MMP8, IL18, KDR, MMP3
41doxorubicin44 49 1111.8GSTT1, GSTP1, IL18, GSTM1, KDR
42arginine449.7KDR, NISCH, GSTT1, IL18, GSTM1, GSTP1
43serine449.6KLK5, CAMP, S100A8, IL18, MMP3, CETP
44estrogen449.6CAMP, IL18, MMP3, KDR, CETP, GSTM1
45cholesterol44 28 11 2412.6SCP2, IL18, MMP3, CETP, S100A8, CAMP
46retinoic acid44 2410.5IL18, S100A8, CAMP, MMP3, MMP8, KDR
47cysteine449.4GSTM1, GSTP1, KDR, MMP8, MMP3, CETP
48creatinine449.4GSTT1, S100A8, ADSL, IL18, MMP3, ALPI
49genistein44 28 59 2 11 2414.4GSTP1, KDR, MMP3, MMP8, CAMP
50lipid449.2MMP3, IL18, CETP, MMP8, GSTT1, ALPI

GO Terms for genes affiliated with Rosacea

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16Gene Ontology
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Cellular components related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4CETP, MMP8, MMP3, IL18, S100A8, KLK5
2extracellular regionGO:0055768.8CETP, KLK5, CAMP, S100A8, IL18, MMP3

Biological processes related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid transportGO:01591410.2CETP, SCP2
2glutathione derivative biosynthetic processGO:19016879.9GSTP1, GSTT1, GSTM1
3glutathione metabolic processGO:0067499.8GSTM1, GSTT1, GSTP1
4positive regulation of superoxide anion generationGO:0329309.8GSTP1, IL18

Molecular functions related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.9GSTP1, GSTT1, GSTM1

Products for genes affiliated with Rosacea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rosacea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet