MCID: RSC001
MIFTS: 50

Rosacea malady

Skin diseases category

Summaries for Rosacea

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Rosacea is a long-term disease that affects your skin and sometimes your eyes. it causes redness and pimples. rosacea is most common in women and people with fair skin. it most often affects middle-aged and older adults. in most cases, rosacea only affects the face. symptoms can include frequent redness of the face, or flushing small, red lines under the skin acne a swollen nose thick skin, usually on the forehead, chin, and cheeks red, dry, itchy eyes and sometimes vision problems no one knows what causes rosacea. you may be more likely to have it if you blush a lot or if rosacea runs in your family. rosacea is not dangerous. there is no cure, but treatments can help. they include medicines and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Rosacea, also known as acne, erythematosa, is related to acne and granulomatous rosacea. An important gene associated with Rosacea is CAMP (cathelicidin antimicrobial peptide). The drugs benzoyl peroxide and metronidazole and the compounds xanthine and p002 have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and b cells.

Wikipedia:66 Rosacea /ro??ze??i?/ is a chronic condition characterized by facial erythema (redness) and sometimes... more...

Aliases & Classifications for Rosacea

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Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

rosacea 9 11 35 63
acne, erythematosa 9
acne rosacea 9
rosacea nos 9
acne roscea 9


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Disease Ontology9 DOID:8881
MeSH36 D012393
ICD9CM28 695.3
ICD1026 L71, L71.9

Related Diseases for Rosacea

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Rosacea:



Diseases related to rosacea

Symptoms for Rosacea

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Drugs & Therapeutics for Rosacea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Rosacea

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Anatomical Context for Rosacea

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Sources:
34MalaCards
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MalaCards organs/tissues related to Rosacea:

34
Skin, Eye, B cells, Endothelial, Small intestine, Testes, Myeloid, Salivary gland

Animal Models for Rosacea or affiliated genes

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Publications for Rosacea

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Sources:
53PubMed
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Articles related to Rosacea:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Antinuclear antibodies in rosacea patients. (24278039)
2013
2
Rosacea - S1 guideline. (23647643)
2013
3
Potential role of microorganisms in the pathogenesis of rosacea. (24011460)
2013
4
Vitamin D status in patients with rosacea. (23713748)
2013
5
Management of facial erythema of rosacea: what is the role of topical I+-adrenergic receptor agonist therapy? (24229637)
2013
6
Migraine, triptans, and the risk of developing rosacea: a population-based study within the United Kingdom. (23643255)
2013
7
Steroid dermatitis resembling rosacea: a clinical evaluation of 75 patients. (23691345)
2013
8
Molecular biologic assessment of cutaneous specimens of ocular rosacea. (22617640)
2012
9
Potential role of Demodex mites and bacteria in the induction of rosacea. (22933353)
2012
10
Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea. (22435439)
2012
11
Is it acne or is it rosacea? An important distinction. (22988645)
2012
12
A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. (22395584)
2012
13
Rosacea. (22727268)
2012
14
Re. Inflammation in rosacea and acne: implications for patient care. (22303551)
2012
15
Facial redness and rosacea... (22183094)
2011
16
Rosacea as a disease of cathelicidins and skin innate immunity. (22076322)
2011
17
Epidermal proteases in the pathogenesis of rosacea. (22076323)
2011
18
Management of Papulopustular Rosacea and Perioral Dermatitis with Emphasis on Iatrogenic Causation or Exacerbation of Inflammatory Facial Dermatoses: Use of Doxycycline-modified Release 40mg Capsule Once Daily in Combination with Properly Selected Skin Care as an Effective Therapeutic Approach. (21909455)
2011
19
Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. (22076328)
2011
20
Long-term efficacy and safety of topical PRK 124 (0.125%) lotion (Pyratine-XR) in the treatment of mild-to-moderate rosacea. (20645526)
2010
21
Clinical and laboratory study of rosacea in northern Greece. (19744179)
2010
22
Updates on the pathophysiology and management of acne rosacea. (19820288)
2009
23
The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol. (19563582)
2009
24
Concentration of selected cytokines in serum of patients with acne rosacea]. (19140384)
2008
25
Successful treatment of erythematotelangiectatic rosacea with pulsed light and radiofrequency. (21103309)
2008
26
Rosacea/acne rosacea: efficacy of combination therapy of azithromycin and topical 0.1% tacrolimus ointment. (18435734)
2008
27
Healthcare utilization and costs of patients with rosacea in an insured population. (18246697)
2008
28
Severe exacerbation of rosacea induced by cinnamon supplements. (18561592)
2008
29
A role for vascular pathogenic mechanisms in rosacea: implications for patient care. (18792539)
2008
30
Combined effect of anti-inflammatory dose doxycycline (40-mg doxycycline, usp monohydrate controlled-release capsules) and metronidazole topical gel 1% in the treatment of rosacea. (17668530)
2007
31
Wegener's granulomatosis mimicking facial granulomatous rosacea: a separate subset? (17989900)
2007
32
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. (17676051)
2007
33
Lymphangiogenesis and angiogenesis in non-phymatous rosacea. (17880579)
2007
34
Rosacea. (18183803)
2007
35
Wegener's granulomatosis presenting with granulomatous facial erythematous papules and plaques mimicking granulomatous rosacea. (16792787)
2006
36
Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea. (16284681)
2005
37
Dendritic keratopathy in ocular rosacea. (15968176)
2005
38
Assessment of skin barrier function in rosacea patients with a novel 1% metronidazole gel. (16167413)
2005
39
Could matrix metalloproteinase-9 be a link between Demodex folliculorum and rosacea? (16164733)
2005
40
Group IIA phospholipase A(2) concentration of tears in patients with ocular rosacea. (16029275)
2005
41
Ocular rosacea. (17131004)
2005
42
Rosacea. An overview of diagnosis and management. (15615217)
2004
43
BsmI polymorphism of the vitamin D receptor gene in patients with the fulminant course of rosacea conglobata (rosacea fulminans). (15187348)
2004
44
A topical azithromycin preparation for the treatment of acne vulgaris and rosacea. (15370397)
2004
45
Helicobacter pylori and rosacea. (15562747)
2003
46
Laser treatment of rosacea. (17147538)
2002
47
Resolution of granulomatous rosacea after eradication of Helicobacter pylori with clarithromycin, metronidazole and pantoprazole. (11692067)
2001
48
Granulomatous rosacea in a child infected with the human immunodeficiency virus. (1479080)
1992
49
Demodicidosis mimicking granulomatous rosacea and transient acantholytic dermatosis (Grover's disease). (2958377)
1987
50
ROSACEA-LIKE DEMODICIDOSIS. (18732637)
1963

Variations for Rosacea

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Expression for genes affiliated with Rosacea

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for genes affiliated with Rosacea

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Compounds for genes affiliated with Rosacea

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Rosacea according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1xanthine46 2510.8ADSL, MMP8
2p002469.7GSTT1, MMP8
3urea46 25 1211.7ADSL, MMP8
48-bromo-cyclic amp469.6CGA, CAMP
5(+-)-pgf2-alpha469.6CAMP, CGA
6percoll469.6CGA, CAMP
7clodronate46 52 1211.6CGA, MMP8
8prostaglandin f2alpha469.6CAMP, CGA
9dbc-amp469.6CGA, CAMP
10ifosfamide46 1210.5CGA, GSTT1
11carboplatin46 52 1211.4CGA, GSTT1
12cytochalasin d46 6210.4CAMP, CGA
13ibmx46 62 3011.4CGA, CAMP
14clonidine46 52 30 1212.4CGA, NISCH
15oligonucleotide469.4GSTT1, CAMP, MMP8
16prostaglandin469.2CGA, CAMP
17cyclophosphamide46 52 1211.2CGA, GSTT1
18pge2469.1CGA, CAMP, MMP8
19folate469.1GSTT1, CGA
20progesterone46 30 62 25 1213.1CGA, CAMP, MMP8
21adenylate469.1CGA, CAMP, ADSL
22vegf469.1CGA, CAMP, MMP8
23steroid469.0CAMP, GSTT1, CGA
24creatinine469.0ADSL, GSTT1, CGA
25prostacyclin468.9CGA, CAMP
26glutamate468.9CGA, CAMP, ADSL
27glucose468.9NISCH, CAMP, MMP8
28lipid468.8MMP8, CAMP, GSTT1, NISCH
29estrogen468.8CGA, GSTT1, CAMP
30arginine468.8GSTT1, NISCH, CGA

GO Terms for genes affiliated with Rosacea

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Sources:
17Gene Ontology
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Cellular components related to Rosacea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.4NISCH, GSTT1, CAMP, ADSL

Products for genes affiliated with Rosacea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rosacea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet