Aliases & Classifications for Rosacea

MalaCards integrated aliases for Rosacea:

Name: Rosacea 12 40 41 14 69 59
Acne, Erythematosa 12
Acne Roscea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8881
ICD10 32 L71 L71.9
ICD9CM 34 695.3
MeSH 41 D012393
NCIt 46 C97136
UMLS 69 C0035854

Summaries for Rosacea

MedlinePlus : 40 Rosacea is a long-term disease that affects your skin and sometimes your eyes. It causes redness and pimples. Rosacea is most common in women and people with fair skin. It most often affects middle-aged and older adults. In most cases, rosacea only affects the face. Symptoms can include Frequent redness of the face, or flushing Small, red lines under the skin Acne A swollen nose Thick skin, usually on the forehead, chin, and cheeks Red, dry, itchy eyes and sometimes vision problems No one knows what causes rosacea. You may be more likely to have it if you blush a lot or if rosacea runs in your family. Rosacea is not dangerous. There is no cure, but treatments can help. They include medicines and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Rosacea, also known as acne, erythematosa, is related to dermatitis, atopic and keratitis, hereditary, and has symptoms including pruritus and exanthema. An important gene associated with Rosacea is CAMP (Cathelicidin Antimicrobial Peptide), and among its related pathways/superpathways are Kaposi's sarcoma-associated herpesvirus infection and IL-17 Family Signaling Pathways. The drugs Ivermectin and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are behavior/neurological and cardiovascular system

PubMed Health : 59
About rosacea: Red patches of skin on your face, and tiny visible blood vessels and spots – these can be quite common symptoms. They may be caused by rosacea, a common facial skin inflammation.Skin diseases can be difficult to cope with, and they often affect people’s self-confidence and wellbeing. But if you have rosacea, there is a lot you can do on your own.

Wikipedia : 72 Rosacea is a long-term skin condition that typically affects the face. It results in redness, pimples,... more...

Related Diseases for Rosacea

Diseases related to Rosacea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 29.9 CAMP TLR2 TNF
2 keratitis, hereditary 29.8 MMP9 TLR2 VEGFA
3 psoriasis 29.6 CAMP IL6 TNF VDR
4 chlamydia 29.3 IL6 TLR2 TNF
5 pneumonia 29.3 IL6 TLR2 TNF
6 migraine with or without aura 1 29.0 IER3IP1 TNF TRPV1
7 gastrointestinal system disease 28.7 IL6 TNF TRPV1
8 granulomatous rosacea 12.5
9 rosacea conjunctivitis 12.0
10 adult dermatomyositis 10.4 TNF VDR
11 trench fever 10.4 TLR2 TNF
12 haemophilus influenzae 10.4 TLR2 TNF
13 scleritis 10.3 MMP9 TNF
14 amaurosis fugax 10.3 MMP8 MMP9
15 penicilliosis 10.3 TLR2 TNF
16 nontuberculous mycobacterial lung disease 10.3 TLR2 TNF
17 mycobacterium abscessus 10.3 TLR2 TNF
18 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
19 dermatitis 10.3
20 squamous cell carcinoma of the hypopharynx 10.3 MMP9 VEGFA
21 alveolar echinococcosis 10.3 TLR2 TNF
22 adamantinous craniopharyngioma 10.3 MMP9 VEGFA
23 microcystic meningioma 10.2 MMP9 VEGFA
24 melancholia 10.2 IER3IP1 TNF
25 adenomyosis 10.2 MMP9 VEGFA
26 diverticulitis 10.2 MMP9 TNF
27 primary systemic mycosis 10.2 TLR2 TNF
28 diabetic foot ulcers 10.2 IL6 MMP9
29 radiation proctitis 10.2 TNF VEGFA
30 acute transverse myelitis 10.2 IL6 MMP9
31 lepromatous leprosy 10.2 TLR2 TNF VDR
32 irritant dermatitis 10.2 IER3IP1 TNF
33 scorpion envenomation 10.2 IL6 TNF
34 back pain 10.2 IL6 MMP9
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
36 streptococcal toxic-shock syndrome 10.2 IL6 TNF
37 pulmonary tuberculosis 10.2 TLR2 TNF VDR
38 null-cell leukemia 10.2 IL6 TNF
39 demodicidosis 10.2
40 mycobacterium tuberculosis 1 10.2 TLR2 TNF VDR
41 retinitis pigmentosa 55 10.2 IL6 TNF
42 sebaceous gland disease 10.2 IER3IP1 TLR2
43 glossitis 10.2 IL6 TNF
44 laryngitis 10.2 IL6 TNF
45 soft tissue sarcoma 10.1 TNF VEGFA
46 anterior uveitis 10.1 IL6 TNF
47 acute vascular insufficiency of intestine 10.1 IL6 TNF
48 posterior urethral valves 10.1 IL6 TNF
49 neovascular glaucoma 10.1 IER3IP1 VEGFA
50 odontogenic myxoma 10.1 MMP9 VEGFA

Graphical network of the top 20 diseases related to Rosacea:



Diseases related to Rosacea

Symptoms & Phenotypes for Rosacea

UMLS symptoms related to Rosacea:


pruritus, exanthema

MGI Mouse Phenotypes related to Rosacea:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 TNF VEGFA TRPV1 VDR MMP9 PTGDR
2 cardiovascular system MP:0005385 10.11 VEGFA TRPV1 VDR TNF PTGDR IL6
3 cellular MP:0005384 10.1 TNF VEGFA TRPV1 VDR CAMP MMP9
4 immune system MP:0005387 10.1 TRPV1 VDR VEGFA TNF CAMP IL6
5 homeostasis/metabolism MP:0005376 10.09 TNF VEGFA TRPV1 VDR MMP9 PTGDR
6 hematopoietic system MP:0005397 10.06 TNF VEGFA VDR MMP9 CAMP PTGDR
7 integument MP:0010771 9.97 VEGFA TRPV1 VDR TNF PTGDR IL6
8 digestive/alimentary MP:0005381 9.95 TNF VEGFA VDR MMP9 IL6 TLR2
9 muscle MP:0005369 9.87 VEGFA VDR TNF PTGDR IL6 TLR2
10 neoplasm MP:0002006 9.8 VEGFA TRPV1 TNF IL6 TLR2 MMP8
11 nervous system MP:0003631 9.76 TNF VEGFA TRPV1 VDR MMP9 PTGDR
12 renal/urinary system MP:0005367 9.43 VEGFA TRPV1 VDR IL6 TLR2 MMP9
13 respiratory system MP:0005388 9.1 TNF VEGFA PTGDR IL6 TLR2 MMP9

Drugs & Therapeutics for Rosacea

PubMedHealth treatment related to Rosacea: 59

There are a lot of creams, lotions and gels recommended for the treatment of rosacea. Creams and gels with either azelaic acid or the antibiotic metronidazole in them are used most commonly. Antibiotics can also be taken as tablets, but then the entire body is affected.

Drugs for Rosacea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 70288-86-7 46936176 6474909
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3
Phenylephrine Approved Phase 4,Phase 3 59-42-7 6041
4
Oxymetazoline Approved, Investigational Phase 4,Phase 3 1491-59-4 4636
5
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
8
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
9
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
10
Azelaic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 123-99-9 2266
11
Sulfacetamide Approved Phase 4 144-80-9 5320
12
Timolol Approved Phase 4,Phase 1 26839-75-8 5478 33624
13 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2,Early Phase 1
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Phase 1 70359-46-5
20 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
22 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Phase 1
23 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
24 Mydriatics Phase 4,Phase 3
25 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2
26 Cyclosporins Phase 4
27 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Photosensitizing Agents Phase 4
31 Antifungal Agents Phase 4
32 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Antimalarials Phase 4,Phase 3,Phase 2
34 Immunosuppressive Agents Phase 4,Phase 2
35 Anti-Inflammatory Agents Phase 4,Phase 2
36 Protective Agents Phase 4,Phase 3
37 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
39 Antirheumatic Agents Phase 4,Phase 2,Phase 1
40 Calcineurin Inhibitors Phase 4,Phase 2
41 Adrenergic Antagonists Phase 4,Phase 1
42 Adrenergic beta-Antagonists Phase 4,Phase 1
43 Anti-Arrhythmia Agents Phase 4,Phase 1
44
Minocycline Approved, Investigational Phase 3,Phase 2,Phase 1 10118-90-8 5281021
45
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
46
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
47
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
48 tannic acid Approved, Nutraceutical Phase 3
49
Tretinoin Approved, Investigational, Nutraceutical Phase 2, Phase 3 302-79-4 5538
50 Clindamycin palmitate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 146)

# Name Status NCT ID Phase Drugs
1 Patient Centered Outcomes in Rosacea: An Exploratory Multi-media Analysis of the Patient Experience on Oracea Completed NCT01872715 Phase 4 Oracea
2 MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea. Completed NCT02616250 Phase 4 Brimonidine 0.33% gel (Br);Ivermectin 1% cream (IVM)
3 Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea Completed NCT00855595 Phase 4 Azelaic acid (Finacea, BAY39-6251);Metronidazole (Metrogel);Doxycycline (Oracea)
4 Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Completed NCT01308619 Phase 4 Doxycycline
5 Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study Completed NCT02147691 Phase 4 Azelaic acid 15%;Brimonidine 0.33%
6 Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens Completed NCT00495313 Phase 4 doxycycline;doxycycline
7 ORCA - Oracea® for Rosacea: A Community-based Assessment Completed NCT00892281 Phase 4 doxycycline (Oracea®) 40 mg modified release as monotherapy;doxycycline (Oracea®) 40 mg modified release as add-on therapy
8 Efficacy of Topical Cyclosporin for Ocular Rosacea Completed NCT00348335 Phase 4 Cyclosporine 0.05%;Ocular lubricant
9 A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily Completed NCT00417937 Phase 4 azelaic acid 15% gel;azelaic acid 15% gel
10 Mirvaso in Use Study Completed NCT02249065 Phase 4 Brimonidine
11 Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Completed NCT01426269 Phase 4 Doxycycline;Metronidazole;Placebo
12 Assess the Ability of MetroGel 1% to Deliver Moisture to Facial Skin After a Single Application Completed NCT00436527 Phase 4 Metronidazole gel 1%
13 Topical Brimonidine to Reduce Inflammation After IPL-treatment in Patients With Facial Telangiectasias Completed NCT02761174 Phase 4 Brimonidine
14 Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea Recruiting NCT03418610 Phase 4 Azelaic Acid foam 15%
15 Photodynamic Therapy for Papulopustular Rosacea Recruiting NCT02075671 Phase 4 Aminolevulinic acid topical solution 20%
16 Internet Surveys and Their Impact on Adherence to Brimonidine Topical Gel and QOL in Patients With Rosacea Recruiting NCT02659670 Phase 4 brimonidine topical gel 0.33%
17 Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With Rosacea Recruiting NCT03380390 Phase 4 Oxymetazoline HCL 1.0% Cream
18 Oracea Soolantra Association in Patients With Severe Rosacea Active, not recruiting NCT03075891 Phase 4 Ivermectin 1% cream;Doxycycline 40 mg MR (30 mg Immediate Release & 10 mg Delayed Release beads) capsules
19 Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea Not yet recruiting NCT03053700 Phase 4 Bromonide 0.33% gel
20 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
21 Topical 0.5% Ivermectin Cream for Treatment of Demodicidosis Unknown status NCT02036229 Phase 3 ivermectin cream 0.5%
22 Azelaic Acid on Demodex Counts in Rosacea Completed NCT03035955 Phase 2, Phase 3 Azelaic acid
23 Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01318733 Phase 3 CD07805/47 gel 0.5%
24 Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea Completed NCT01555463 Phase 3 Azelaic acid foam, 15% (BAY39-6251);Vehicle foam
25 Randomized, Double-blind, Multiple-site, Placebo-controlled, Parallel-design Study in Patients With Moderate to Severe Facial Erythema Associated With Rosacea Completed NCT02289352 Phase 3 Brimonidine;placebo
26 A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea Completed NCT02393937 Phase 3 Reference: Metronidazole Gel 1%;Test: Metronidazole Gel 1%;Placebo Gel
27 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01355458 Phase 3 CD07805/47 gel;Placebo
28 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea Completed NCT01355471 Phase 3 CD07805/47 Gel;Placebo
29 A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea Completed NCT02120924 Phase 3 Azelaic acid
30 A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Patients With Rosacea Completed NCT03287791 Phase 3 Azelaic acid (Finacea®) Foam;Generic Azelaic Acid Foam;Vehicle Foam
31 Determine the Effect of Administering Periostat(R) Twice Daily on Patients With Acne Rosacea Completed NCT00041977 Phase 3 doxycycline hyclate 20 mg twice daily
32 Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea Completed NCT00823901 Phase 2, Phase 3 Clindamycin Phosphate 1.2% And Tretinoin 0.025% Gel;Placebo gel
33 Phase 3 Papulopustular Rosacea Study Completed NCT01494467 Phase 3 CD5024;Azelaic acid 15% Gel
34 Phase 3 Papulopustular Rosacea Study Completed NCT01493687 Phase 3 CD5024;Azelaic acid 15% Gel
35 Isotretinoin in Papular-Pustular Rosacea Completed NCT00882531 Phase 3 isotretinoin;placebo
36 CD5024 1% [Ivermectin 1%] Cream Versus Metronidazole 0.75% Cream in Papulopustular Rosacea (PPR) Study Completed NCT01493947 Phase 3 Ivermectin 1% cream;Metronidazole 0.75% cream
37 A Long-Term Safety and Efficacy Study AGN-19920 in Patients With Persistent Erythema Associated With Rosacea Completed NCT02095158 Phase 3 Oxymetazoline HCL Cream 1.0%
38 Study of 0444 Gel in the Treatment of Inflammatory Lesions of Rosacea Completed NCT01016782 Phase 3 0444
39 Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea Completed NCT02132117 Phase 3 Oxymetazoline HCL Cream 1.0%;Vehicle to Oxymetazoline HCL Cream
40 Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea Completed NCT01659853 Phase 3 CD07805/47 gel 0.5%/CD07805/47 Vehicle;azelaic acid gel 15%
41 A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea Completed NCT00126399 Phase 3 doxycycline
42 Clinical Endpoint Study of Ivermectin 1% Cream Completed NCT02840461 Phase 3 Ivermectin Cream, 1%;Placebo/Vehicle cream
43 Bioequivalence Study of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea on the Face Completed NCT02800148 Phase 3 Azelaic acid foam;Azelaic acid foam;Azelaic acid foam - Placebo
44 Comparative Safety and Efficacy of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea Completed NCT02795117 Phase 3 Ivermectin;Ivermectin (reference);Placebo
45 Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema of Rosacea Completed NCT01789775 Phase 3 Drug: CD07805/47 gel;CD07805/47 gel Placebo
46 Comparative Safety and Efficacy of Two Rosacea Products in the Treatment of Facial Erythema of Rosacea Completed NCT02385240 Phase 3 Brimonidine Topical Gel, 0.33 percent (Perrigo);Brimonidine Topical Gel, 0.33 percent (Reference);Placebo gel
47 Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle Completed NCT02576860 Phase 3 CLS001 (Omiganan);Vehicle
48 Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With Rosacea Completed NCT02131636 Phase 3 AGN-199201;Vehicle to AGN-199201
49 Patient-Reported Outcome Of Facial Erythema (PROOF) Completed NCT01885000 Phase 3 once-daily brimonidine tartrate 0.5% gel;once-daily brimonidine tartrate vehicle gel
50 An Evaluation of the Reduction in Erythema in Adult Patients With Moderate to Severe Persistent Facial Erythema Associated With Rosacea Recruiting NCT03352323 Phase 3 Oxymetazoline

Search NIH Clinical Center for Rosacea

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rosacea

Genetic Tests for Rosacea

Anatomical Context for Rosacea

MalaCards organs/tissues related to Rosacea:

38
Skin, Eye, Testes, B Cells, Small Intestine, Endothelial, Neutrophil

Publications for Rosacea

Articles related to Rosacea:

(show top 50) (show all 710)
# Title Authors Year
1
Frontal fibrosing alopecia and cutaneous comorbidities: A potential relationship with rosacea. ( 29447678 )
2018
2
Reply to: "Rosacea and alcohol intake". ( 29241804 )
2018
3
A Phase II, Randomized, Double-Blind Clinical Study Evaluating the Safety, Tolerability, and Efficacy of a Topical Minocycline Foam, FMX103, for the Treatment of Facial Papulopustular Rosacea. ( 29396702 )
2018
4
Efficacy and Safety of Topical Oxymetazoline Cream 1.0% for Treatment of Persistent Facial Erythema Associated With Rosacea: Findings From the Two Phase 3, 29-Day, Randomized, Controlled REVEAL Trials. ( 29409915 )
2018
5
In Vitro Safety Pharmacology Profiling of Topical I+-Adrenergic Agonist Treatments for Erythema of Rosacea. ( 29374829 )
2018
6
Efficacy and Safety of Oxymetazoline Cream 1.0% for Treatment of Persistent Facial Erythema Associated With Rosacea: Findings From the 52-Week Open Label REVEAL Trial. ( 29409914 )
2018
7
Social factors and aromatase gene expression during adult male-to-female sex change in captive leopard grouper Mycteroperca rosacea. ( 29357278 )
2018
8
Prevalence of gastrointestinal comorbidities in rosacea: Comparison of subantimicrobial, modified release doxycycline versus conventional release doxycycline. ( 29332715 )
2018
9
To test or not to test: A study examining the return rates of rosacea patients treated with a pulsed dye laser. ( 29388860 )
2018
10
Demodex and rosacea: Is there a relationship? ( 29283119 )
2018
11
Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice. ( 29256058 )
2018
12
Rosacea and alcohol intake. ( 29126626 )
2018
13
Pivotal Trial of the Efficacy and Safety of Oxymetazoline Cream 1.0% for the Treatment of Persistent Facial Erythema Associated With Rosacea: Findings from the First REVEAL Trial. ( 29320594 )
2018
14
Inate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study. ( 29330632 )
2018
15
Comparison of efficacy between long-pulsed Nd:YAG laser and pulsed dye laser to treat rosacea-associated nasal telangiectasia. ( 29388843 )
2018
16
Rosacea and Helicobacter pylori: links and risks. ( 28848358 )
2017
17
Risk of inflammatory bowel disease in patients with rosacea: Results from a nationwide cohort study in Taiwan. ( 28073582 )
2017
18
Swiss S1 guideline for the treatment of rosacea. ( 28833645 )
2017
19
Oxymetazoline hydrochloride cream for facial erythema associated with rosacea. ( 28837365 )
2017
20
The dermatology life quality index (DLQI) and the hospital anxiety and depression (HADS) in Chinese rosacea patients. ( 28797174 )
2017
21
Comment on "Effects of Helicobacter pylori treatment on rosacea: A single-arm clinical trial study". ( 28791736 )
2017
22
Rosacea treatment schema: an update. ( 28873101 )
2017
23
Treatment of Ocular Rosacea. ( 28782548 )
2017
24
The Role of Skin Care in Optimizing Treatment of Acne and Rosacea. ( 28492949 )
2017
25
Lack of significant anti-inflammatory activity with clindamycin in the treatment of rosacea: results of 2 randomized, vehicle-controlled trials. ( 28873109 )
2017
26
Diet and rosacea: the role of dietary change in the management of rosacea. ( 29214107 )
2017
27
Characterization of the facial microbiome in twins discordant for rosacea. ( 29283459 )
2017
28
Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study. ( 28915286 )
2017
29
Immune deficiency and rosacea. ( 28846159 )
2017
30
The relationship between migraine and rosacea: Systematic review and meta-analysis. ( 28920449 )
2017
31
Otophyma, Rhinophyma and Telangiectatic Rosacea - A Rare Combination in a Female Patient. ( 28785351 )
2017
32
Can Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea? ( 28871930 )
2017
33
A photoconverter gel-assisted blue light therapy for the treatment of rosacea. ( 28884800 )
2017
34
Rosacea and demodicidosis associated with gain-of-function mutation in STAT1. ( 28622416 )
2017
35
An unusual presentation of ocular rosacea. ( 29267579 )
2017
36
An empirically generated responder definition for rosacea treatment. ( 28932125 )
2017
37
Ocular Rosacea Causing Corneal Melt in an African American Patient and a Hispanic Patient. ( 29158934 )
2017
38
Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study. ( 29364439 )
2017
39
Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis. ( 28711190 )
2017
40
Granulomatous rosacea: a case report. ( 28822351 )
2017
41
Comment on "Effects of Helicobacter pylori treatment on rosacea: A single-arm clinical trial study". ( 28791740 )
2017
42
Treatment of erythemato-telangiectatic rosacea with brimonidine alone or combined with vascular laser based on preliminary instrumental evaluation of the vascular component. ( 28889348 )
2017
43
Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma. ( 29071268 )
2017
44
Quality of Life Measurement in Acne. Position Paper of the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS). ( 28898474 )
2017
45
The usefulness of investigating the possible underlying conditions in rosacea. ( 28846817 )
2017
46
Clinical and Histologic Effects of Fractional Microneedling Radiofrequency Treatment on Rosacea. ( 27608206 )
2016
47
Clinical assessment of rosacea severity: oriental score vs. quantitative assessment method with imaging and biomedical tools. ( 27514310 )
2016
48
Rosacea: a Clinical Review. ( 27942368 )
2016
49
Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris. ( 28083023 )
2016
50
The Effect of Recurrent Pulsed Dye Laser Treatments in Rosacea Patients. ( 27922281 )
2016

Variations for Rosacea

Expression for Rosacea

Search GEO for disease gene expression data for Rosacea.

Pathways for Rosacea

Pathways related to Rosacea according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 IL6 MMP9 TLR2 TNF VEGFA
2
Show member pathways
12.14 IL6 MMP9 TLR2 TNF
3
Show member pathways
12.1 IL6 TLR2 TNF
4 12.09 MMP9 TLR2 TNF VEGFA
5
Show member pathways
12.03 IL6 TLR2 TNF
6 12.02 IL6 TNF VEGFA
7 11.93 MMP9 TNF VEGFA
8 11.86 IL6 MMP9 TNF
9 11.8 IL6 MMP9 TNF
10
Show member pathways
11.78 IL6 TLR2 TNF
11 11.75 IL6 TNF VEGFA
12
Show member pathways
11.74 MMP8 MMP9 TNF
13 11.72 IL6 TLR2 TNF
14 11.68 IL6 MMP9 TNF VEGFA
15 11.61 CAMP IL6 TLR2 TNF VDR
16 11.54 IL6 TLR2 TNF
17 11.51 IL6 MMP9 TNF
18 11.51 IL6 TLR2 TNF VEGFA
19 11.46 MMP9 PTGDR VEGFA
20 11.41 IL6 TLR2 TNF
21 11.32 IL6 TLR2 TNF
22 11.29 IL6 MMP9 TNF
23
Show member pathways
11.26 IL6 MMP9 TNF VEGFA
24 11.24 IL6 MMP9 TLR2 TNF VEGFA
25 11.23 IL6 TNF VDR
26 11.04 MMP9 TLR2
27 11.02 MMP9 VEGFA
28 10.97 IL6 TNF
29 10.9 IL6 TNF
30 10.74 TNF VDR

GO Terms for Rosacea

Cellular components related to Rosacea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CAMP IL6 MMP8 MMP9 TNF VEGFA
2 tertiary granule lumen GO:1904724 8.8 CAMP MMP8 MMP9

Biological processes related to Rosacea according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 IL6 TLR2 TNF VDR VEGFA
2 neutrophil degranulation GO:0043312 9.85 CAMP MMP8 MMP9 TLR2
3 positive regulation of apoptotic process GO:0043065 9.73 IL6 MMP9 TNF TRPV1
4 positive regulation of protein phosphorylation GO:0001934 9.71 MMP9 TNF VEGFA
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 IL6 TLR2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.67 CAMP IL6 TNF
7 inflammatory response GO:0006954 9.65 IL6 PTGDR TLR2 TNF TRPV1
8 endodermal cell differentiation GO:0035987 9.6 MMP8 MMP9
9 positive regulation of interleukin-8 production GO:0032757 9.59 TLR2 TNF
10 positive regulation of protein complex assembly GO:0031334 9.58 TNF VEGFA
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.57 TLR2 TNF
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 MMP9 TNF
13 positive regulation of gene expression GO:0010628 9.55 IL6 TLR2 TNF VDR VEGFA
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.54 IL6 TNF VEGFA
15 macrophage differentiation GO:0030225 9.51 MMP9 VEGFA
16 positive regulation of interleukin-6 production GO:0032755 9.5 IL6 TLR2 TNF
17 microglial cell activation GO:0001774 9.48 TLR2 TRPV1
18 negative regulation of growth of symbiont in host GO:0044130 9.46 CAMP TNF
19 negative regulation of lipid storage GO:0010888 9.4 IL6 TNF
20 positive regulation of chemokine production GO:0032722 9.13 IL6 TLR2 TNF
21 defense response to Gram-positive bacterium GO:0050830 8.92 CAMP IL6 TLR2 TNF

Sources for Rosacea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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