MCID: RBL001
MIFTS: 59

Rubella malady

Infectious diseases category

Summaries for Rubella

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Rubella is an infection caused by a virus. it is usually mild with fever and a rash. about half of the people who get rubella do not have symptoms. if you do get them, symptoms may include a rash that starts on the face and spreads to the body mild fever aching joints, especially in young women swollen glands rubella is most dangerous for a pregnant woman's baby. it can cause miscarriage or birth defects. rubella spreads when an infected person coughs or sneezes. people without symptoms can still spread it. there is no treatment, but the measles-mumps-rubella (mmr) vaccine can prevent it. centers for disease control and prevention

MalaCards: Rubella, also known as german measles, is related to measles and hepatitis, and has symptoms including rash on the face which spreads to the trunk, lymphadenopathy and joint pains. An important gene associated with Rubella is CD40LG (CD40 ligand), and among its related pathways are Regulation of thyroid hormone activity and Immune response IL-22 signaling pathway. The compounds rubella and gliadin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in rubella virus, which is transmitted by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted by congenital method. the infection has symptom rash on the face which spreads to the trunk and limbs, has symptom fever, has symptom lymphadenopathy, has symptom joint pains, has symptom headache, and has symptom conjunctivitis.

CDC:3 Turns out that this pipsqueak has a much more sinister goal than just making big people a little bit sick—it's after babies…

Wikipedia:63 Rubella, also known as German measles or three-day measles, is a disease caused by the rubella virus.... more...

Aliases & Classifications for Rubella

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Related Diseases for Rubella

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17GeneCards, 18GeneDecks
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Diseases in the Rubella family:

Congenital Rubella

Diseases related to Rubella via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1measles31.6RNPC3, CD40LG
2hepatitis30.6CD40LG, CAT
3influenza30.5CALR, RNPC3
4hepatitis b30.5IFNA21, TRIM22, RNPC3
5encephalitis30.5ZNF175, GAD2, CAT
6diabetes mellitus30.4CD40LG, GAD2, CAT, CALR
7toxoplasmosis30.4CD40LG
8uveitis30.3RNPC3
9thyroiditis30.3TPO, GAD2
10herpes simplex30.2UNG
11leukemia30.1IL3RA, CD40LG, TRIM5, CAT
12hepatitis c29.9C1QBP, IFNA21, TRIM22, CD40LG, RNPC3
13vasculitis29.9CD40LG
14tuberculosis29.7TPO, CALR
15schizophrenia29.7GAD2
16mumps11.0
17congenital rubella10.4
18aseptic meningitis10.3
19meningitis10.3
20tetanus10.3
21cataract10.3
22diphtheria10.2
23hepatitis a10.2
24exanthem10.2
25pertussis10.2
26myelitis10.2
27arthritis10.2
28multiple sclerosis10.2
29poliomyelitis10.2
30purpura10.2
31chickenpox10.1
32autism spectrum disorder10.1
33iridocyclitis10.1
34syphilis10.1
35subacute sclerosing panencephalitis10.1
36acute leukemia10.1
37hemolytic anemia10.1
38hypothyroidism10.1
39lymphoblastic leukemia10.1
40autoimmune thyroiditis10.0TPO
41lupus erythematosus10.0CD40LG, CALR
42graves' disease10.0TPO, GAD2
43celiac disease10.0TPO, HLA-DPA1, CALR
44sarcoma10.0TPO
45hypersensitivity reaction type ii disease10.0GAD2
46mixed connective tissue disease10.0RNPC3
47sjogren's syndrome10.0RNPC3, CD40LG, CALR
48rheumatoid arthritis10.0CALR, HLA-DPB1, CD40LG, RNPC3
49myasthenia gravis10.0HLA-DPB1
50endocarditis10.0C1QBP

Graphical network of the top 20 diseases related to Rubella:



Diseases related to rubella

Clinical Features for Rubella

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Sources:
8Disease Ontology
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Symptoms:

8
  • rash on the face which spreads to the trunk
  • lymphadenopathy
  • joint pains
  • headache
  • conjunctivitis
  • fever

Drugs & Therapeutics for Rubella

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rubella

Drug clinical trials:

Search ClinicalTrials for Rubella

Search NIH Clinical Center for Rubella

Search CenterWatch for Rubella

Genetic Tests for Rubella

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Anatomical Context for Rubella

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Rubella:

32
Skin, Testes, T cells, Thyroid, Eye, Brain, Endothelial, Breast, Heart, Whole blood, Salivary gland, Lymph node, Placenta, Liver, Bone

FMA organs/tissues related to Rubella:

14
Skin

Animal Models for Rubella or affiliated genes

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Publications for Rubella

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Sources:
50PubMed
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Articles related to Rubella:

(show top 50)    (show all 1065)
idTitleAuthorsYear
1
High-throughput Assay Optimization and Statistical Interpolation of Rubella-Specific Neutralizing Antibody Titers. (24391140)
2014
2
Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts. (24375276)
2014
3
Ongoing outbreak of rubella among young male adults in Poland: increased risk of congenital rubella infections. (23725976)
2013
4
Seropositivity rates for measles, mumps, and rubella IgG and costs associated with testing and revaccination. (23345583)
2013
5
Moving forward with strengthening routine immunization delivery as part of measles and rubella elimination activities. (23598472)
2013
6
Total blood mercury and rubella antibody concentrations in US children aged 6-11 years, NHANES 2003-2004. (23178763)
2013
7
Comparison of hemagglutination inhibition assay and enzyme immunoassay for determination of mumps and rubella immune status in health care personnel. (24038230)
2013
8
The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case-control study in Asia. (22521285)
2012
9
Viral molecular characterization of the first congenital rubella syndrome case in Vietnam. (21755831)
2011
10
Attitudinal and demographic predictors of measles, mumps and rubella (MMR) vaccine acceptance: development and validation of an evidence-based measurement instrument. (21185850)
2011
11
Blood-borne transmission of the measles, mumps, and rubella vaccine virus. (21388395)
2011
12
Congenital rubella syndrome with autistic disorder. (20171592)
2010
13
The rubella virus capsid protein inhibits mitochondrial import. (19846524)
2010
14
Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan. (19732080)
2010
15
Prevalence of toxoplasmosis, HIV, syphilis and rubella in a population of puerperal women using Whatman 903 filter paper. (20428650)
2010
16
Thrombocytopenic purpura after measles-mumps-rubella vaccination: a systematic review of the literature and guidance for management. (20097358)
2010
17
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. (19007835)
2009
18
Prevention of congenital rubella and congenital varicella in Europe. (19317971)
2009
19
Skin peptides from anurans of the Litoria rubella Group: sequence determination using electrospray mass spectrometry. Opioid activity of two major peptides. (19291693)
2009
20
Seroprevalence of rubella among Turkish women and children in Afyonkarahisar, Turkey. (20196385)
2009
21
Serologic survey of specific rubella virus IgM in the sera of pregnant women in Makurdi, Benue State, Nigeria. (20690250)
2009
22
Safety and immunogenicity of early vaccination with two doses of tetravalent measles-mumps-rubella-varicella (MMRV) vaccine in healthy children from 9 months of age. (17710370)
2007
23
Congenital rubella syndrome: the end is in sight. (17947261)
2007
24
Rubella infection with autoimmune hemolytic anemia. (17526964)
2007
25
Evaluation of a commercial rubella IgM assay for use on oral fluid samples for diagnosis and surveillance of congenital rubella syndrome and postnatal rubella. (17049919)
2006
26
Costs of congenital rubella syndrome (CRS) in Oman: evidence based on long-term follow-up of 43 children. (16814433)
2006
27
Severe aortic regurgitation: an exceptional cardiac manifestation of congenital rubella syndrome. (16904771)
2006
28
Reducing the global burden of congenital rubella syndrome: report of the World Health Organization Steering Committee On Research Related To Measles and Rubella Vaccines and Vaccination, June 2004. (16267759)
2005
29
Congenital rubella syndrome - Time to act on missed prevention opportunities. (20019928)
2003
30
Investigation of a rubella outbreak in Kyrgyzstan in 2001: implications for an integrated approach to measles elimination and prevention of congenital rubella syndrome. (12721919)
2003
31
Congenital rubella: down but not out. (12241853)
2002
32
Congenital rubella infection control problem. (11731673)
2001
33
Congenital rubella syndrome: The need for standing orders for vaccination of susceptible women. (20084201)
2001
34
Rubella and congenital rubella syndrome. (10063703)
1998
35
Resurgence of congenital rubella syndrome in the 1990s. Report on missed opportunities and failed prevention policies among women of childbearing age. (1573748)
1992
36
Increase in rubella and congenital rubella syndrome--United States, 1988-1990. (1899464)
1991
37
Development of a highly specific and sensitive rubella immunoglobulin M antibody capture enzyme immunoassay that uses enzyme-labeled antigen. (2185260)
1990
38
Subacute sclerosing panencephalitis, progressive rubella panencephalitis, and multifocal leukoencephalopathy. (2183315)
1990
39
Calculation of the frequency of congenital rubella syndrome in Poland. (2902771)
1988
40
International symposium on prevention of congenital rubella infection. Washington, D.C., March 13-15, 1984. (4001717)
1985
41
Retrospective diagnosis of congenital rubella. (6439320)
1984
42
Economic evaluation of different vaccination programmes to prevent congenital rubella. (6820478)
1982
43
Rubella virus reinfection during pregnancy leading to late-onset congenital rubella syndrome. (7062206)
1982
44
Adult-onset Still's disease: an unusual presentation of rubella infection. (7388725)
1980
45
Impaired cell-mediated immune response in patients with congenital rubella: correlation with gestational age at time of infection. (386238)
1979
46
Comparison of immunofluorescence and radioimmunoassay for detecting IgM antibody in infants with the congenital rubella syndrome. (229160)
1979
47
Progressive rubella panencephalitis: clinical course and response to 'isoprinosine'. (92431)
1979
48
Prenatal diagnosis of congenital rubella. (843835)
1977
49
Progressive rubella panencephalitis. (973810)
1976
50
Letter: Diabetes, HL-A antigens, and congenital rubella. (4140412)
1974

Genetic Variations for Rubella

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Expression for genes affiliated with Rubella

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rubella

Search GEO for disease gene expression data for Rubella.

Pathways for genes affiliated with Rubella

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TPO, GAD2
210.4IL12A, HLA-DPB1, HLA-DPA1
3
Hide members
10.4HLA-DPA1, HLA-DPB1, CD40LG, IL12A
410.4TPO, IL3RA, IL12A, IFNA21
510.4IFNA21, HLA-DPA1, HLA-DPB1, IL12A
6
Hide members
10.4TPO, IL3RA, IL12A, CD40LG, IFNA21
7
Hide members
10.4IFNA21, HLA-DPA1, HLA-DPB1, IL3RA
8
Hide members
10.4CALR, IFNA21, HLA-DPA1, HLA-DPB1, CD40LG, IL3RA
9
Hide members
10.3C1QBP, IFNA21, HLA-DPA1, HLA-DPB1, IL12A
10
Hide members
10.3IL12A, CD40LG, HLA-DPB1, HLA-DPA1, GAD2, IFNA21

Compounds for genes affiliated with Rubella

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Rubella according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1rubella4410.7CD40LG, CALR
2gliadin4410.7TPO, CD40LG, GAD2, CALR
3hydrogen44 2411.7CALR, AGA, RNPC3, TPO
4dpa 14410.6HLA-DPB1, HLA-DPA1
5oligonucleotide4410.6CALR, UNG, GAD2, HLA-DPB1, RNPC3, TPO
6iron44 2411.6CALR, CAT, NDUFB4, RNPC3, TPO
7glutamate4410.5CALR, UNG, GAD2, HLA-DPB1, CD40LG, TPO
8guaiacol44 2411.5TPO, CAT
9adenylate4410.5CALR, TRIM22, CD40LG, RNPC3, TPO
10biotin44 11 2412.4RNPC3, CD40LG, C1QBP
11cysteine4410.4CALR, CAT, GAD2, AGA, CD40LG, TPO
12deoxyribose44 2411.3UNG, CAT
13acetylcholine44 49 28 11 2414.1GAD2, TRIM22, CD40LG, TPO

GO Terms for genes affiliated with Rubella

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16Gene Ontology
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Cellular components related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579410.4CAT, LST1, TRIM5, TRIM22, CALR
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-DPB1, HLA-DPA1, CALR
3MHC class II protein complexGO:04261310.1HLA-DPB1, HLA-DPA1

Biological processes related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160710.5ZNF175, TRIM22, TRIM5, IFNA21
2positive regulation of dendritic cell chemotaxisGO:200051010.4C1QBP, CALR
3immune responseGO:00695510.4C1QBP, LST1, HLA-DPA1, TRIM22, IL12A
4modulation by virus of host morphology or physiologyGO:01904810.4TRIM22, TRIM5, UNG, C1QBP
5positive regulation of substrate adhesion-dependent cell spreadingGO:190002610.3CALR, C1QBP
6protein trimerizationGO:07020610.1TRIM22, TRIM5

Molecular functions related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1q bindingGO:00184910.4CALR, C1QBP

Products for genes affiliated with Rubella

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rubella

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet