MCID: RBL001
MIFTS: 62

Rubella malady

Rare diseases, Infectious diseases, Skin diseases, Fetal diseases, Neuronal diseases categories
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Summaries for Rubella

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Rubella is an infection caused by a virus. it is usually mild with fever and a rash. about half of the people who get rubella do not have symptoms. if you do get them, symptoms may include a rash that starts on the face and spreads to the body mild fever aching joints, especially in young women swollen glands rubella is most dangerous for a pregnant woman's baby. it can cause miscarriage or birth defects. rubella spreads when an infected person coughs or sneezes. people without symptoms can still spread it. there is no treatment, but the measles-mumps-rubella (mmr) vaccine can prevent it. centers for disease control and prevention

MalaCards: Rubella, also known as german measles, is related to encephalitis and tetanus, and has symptoms including conjunctivitis, headache and joint pains. An important gene associated with Rubella is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Malaria. The compounds rubella and cytidine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes, and related mouse phenotypes are nervous system and immune system.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in rubella virus, which is transmitted by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted by congenital method. the infection has symptom rash on the face which spreads to the trunk and limbs, has symptom fever, has symptom lymphadenopathy, has symptom joint pains, has symptom headache, and has symptom conjunctivitis.

CDC:4 Turns out that this pipsqueak has a much more sinister goal than just making big people a little bit sick—it's after babies…

Wikipedia:65 Rubella, also known as German measles or three-day measles, is a disease caused by the rubella virus.... more...

Aliases & Classifications for Rubella

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 40NCIt, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Related Diseases for Rubella

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Rubella:



Diseases related to rubella

Symptoms for Rubella

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8Disease Ontology
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Symptoms:

8
  • conjunctivitis
  • headache
  • joint pains
  • lymphadenopathy
  • fever
  • rash on the face which spreads to the trunk

Drugs & Therapeutics for Rubella

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rubella

Search NIH Clinical Center for Rubella

Genetic Tests for Rubella

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Anatomical Context for Rubella

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Rubella:

33
Skin, Testes, T cells, Thyroid, Eye, Brain, Endothelial, Whole blood, Heart, Breast, Placenta, Salivary gland, Lymph node, Bone

FMA organs/tissues related to Rubella:

14
Skin

Animal Models for Rubella or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Rubella:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4AGA, CD40LG, GAD2, CALR, UNG
2MP:00053878.3UNG, TPO, IL12A, GAD2, CD40LG
3MP:00053848.0UNG, CALR, CAT, CD40LG, AGA
4MP:00053767.0AGA, UNG, TPO, IL12A, CALR, CAT
5MP:00107686.9UNG, TPO, IL12A, CALR, CAT, GAD2

Publications for Rubella

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Sources:
52PubMed
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Articles related to Rubella:

(show top 50)    (show all 1051)
idTitleAuthorsYear
1
Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles-mumps-rubella. (24412300)
2014
2
Investigation of an outbreak of hypersensitivity-type reactions during the 2004 national measles-mumps-rubella vaccination campaign in Brazil. (23246259)
2013
3
Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan. (24270137)
2013
4
Rubella in Poland in 2011. (24040714)
2013
5
The importance of fundus eye testing in rubella-induced deafness. (23911114)
2013
6
Congenital rubella syndrome: a review of laboratory data from 2002 to 2011. (24050074)
2013
7
Enabling implementation of the Global Vaccine Action Plan: developing investment cases to achieve targets for measles and rubella prevention. (23598476)
2013
8
Congenital rubella syndrome and left pulmonary artery sling. (22298614)
2012
9
An outbreak of rubella in the Federation of Bosnia and Herzegovina between December 2009 and May 2010 indicates failure to vaccinate during wartime (1992-1995). (21524344)
2012
10
Letter to the editor: commitment needed for the prevention of congenital rubella syndrome in Europe. (22433598)
2012
11
Pityriasis lichenoides et varioliformis acuta: a rare association with the measles, mumps and rubella vaccine. (23157791)
2012
12
Rubella vaccines: WHO position paper--recommendations. (21930175)
2011
13
Development of microsatellite markers in Capsella rubella and Capsella bursa-pastoris (Brassicaceae). (21700797)
2011
14
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
15
Application of new assays for rapid confirmation and genotyping of isolates of rubella virus. (21108356)
2011
16
Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses. (21441098)
2011
17
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. (20001730)
2010
18
Surveillance and control of rubella in the republic of Korea from 2001 to 2009: the necessity for enhanced surveillance to monitor congenital rubella syndrome. (24159436)
2010
19
Development of a novel TaqMan real-time PCR assay for detecting rubella virus RNA. (20580632)
2010
20
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
21
Could the United States experience rubella outbreaks as a result of vaccine refusal and disease importation? (21150305)
2010
22
Closer look at autism and the measles-mumps-rubella vaccine. (21071320)
2010
23
A measles and rubella (MR) catch-up vaccination campaign in an Egyptian University: vaccine uptake and knowledge and attitudes of students. (20797454)
2010
24
A relapse of systemic type juvenile idiopathic arthritis after a rubella vaccination in a patient during a long-term remission period. (19576941)
2009
25
Chlamydia trachomatis and rubella antibodies in women with full-term deliveries and women with abortion in Baghdad. (20218131)
2009
26
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. (19007835)
2009
27
Development of the rubella vaccine and vaccination strategy in Japan. (19366581)
2009
28
Humoral immune response to primary rubella virus infection. (16522781)
2006
29
Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)
2005
30
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
31
The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997. (12435771)
2002
32
Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies. (10390298)
1999
33
Use of PCR for prenatal and postnatal diagnosis of congenital rubella. (8576339)
1995
34
Identification of calreticulin as a rubella virus RNA binding protein. (7809119)
1994
35
Detection of rubella virus-specific immunoglobulin G (IgG), IgM, and IgA antibodies by immunoblot assays. (1572968)
1992
36
Rubella surveillance to december 1990: a joint report from the PHLS and National Congenital Rubella Surveillance Programme. (1669769)
1991
37
Development of a highly specific and sensitive rubella immunoglobulin M antibody capture enzyme immunoassay that uses enzyme-labeled antigen. (2185260)
1990
38
Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis. (2470776)
1989
39
Congenital rubella syndrome in Malaysia. (3831727)
1985
40
Birth and death of congenital rubella syndrome. (6700106)
1984
41
The HLA system in congenital rubella patients with and without diabetes. (6959935)
1982
42
Congenital rubella syndrome: a continuing problem. (6799666)
1982
43
Congenital rubella, insulitis, and diabetes mellitus in an infant. (6112424)
1981
44
Keratoconus and acute hydrops in mentally retarded patients with congenital rubella syndrome. (7468739)
1981
45
Impaired cell-mediated immune response in patients with congenital rubella: correlation with gestational age at time of infection. (386238)
1979
46
The devastating effects of congenital rubella. (106205)
1979
47
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
48
Congenital rubella: the teenage years. (579450)
1977
49
Congenital rubella--an encapsulated review. (960007)
1976
50
Impaired cellular immunity to rubella virus in congenital rubella. (4808855)
1974

Variations for Rubella

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Expression for genes affiliated with Rubella

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rubella

Search GEO for disease gene expression data for Rubella.

Pathways for genes affiliated with Rubella

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50PathCards, 30KEGG, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database
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Pathways related to Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD40LG, UNG
29.6CD40LG, IL12A
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1IL12A, HLA-DPB1
4
Show member pathways
8.8HLA-DPB1, IL12A, CD40LG
5
Show member pathways
7.6CD40LG, GAD2, CALR, IL12A, TPO, HLA-DPB1

Compounds for genes affiliated with Rubella

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Rubella according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1rubella4510.2CD40LG, CALR
2cytidine45 24 1112.1CD40LG, UNG
3valproate4510.1CD40LG, CALR
4cardiolipin45 1111.0TPO, CD40LG
5deoxyribose45 2411.0CAT, UNG
6maltose45 1111.0GAD2, TPO
7125i4510.0GAD2, TPO
8tert-butylhydroperoxide459.9CALR, CAT
9mycophenolate mofetil45 51 1111.9IL12A, CD40LG
10hypoxanthine45 24 1111.9CAT, UNG
11guaiacol45 2410.9CAT, TPO
12Hydrogen peroxide249.8CAT, TPO
13c-peptide459.8TPO, GAD2
14selenium45 2410.7CAT, TPO
15tetracycline45 1110.7CD40LG, TPO
16polysaccharide459.7CD40LG, CALR, TPO
17acetylcholine45 51 29 24 1113.6TPO, GAD2, CD40LG
18n acetylcysteine459.6CD40LG, CAT, CALR
19levodopa45 1110.5GAD2, CAT
20ascorbic acid45 2410.5TPO, CAT, CD40LG
21lactate459.5CALR, CAT, CD40LG
22adenylate459.4TPO, CALR, CD40LG
23superoxide45 2410.4CAT, CALR, UNG
24uric acid45 2410.4TPO, CAT
25iron45 2410.4CAT, CALR, TPO
26gliadin459.3CD40LG, GAD2, CALR, TPO
27aspartate459.2AGA, CD40LG, TPO
28cycloheximide459.2CAT, TPO, UNG
29n-acetylglucosamine459.2CALR, AGA
30h2o2459.2UNG, TPO, CALR, CAT
31threonine459.1AGA, GAD2, CALR, UNG
32nitric oxide45 24 1111.1TPO, CALR, CAT, GAD2
33hydrogen45 249.7UNG, TPO, CALR, GAD2, AGA
34oligonucleotide458.5HLA-DPB1, UNG, TPO, CALR, GAD2
35cysteine458.2TPO, CALR, CAT, GAD2, CD40LG, AGA
36glutamate458.2HLA-DPB1, UNG, TPO, CALR, GAD2, CD40LG

GO Terms for genes affiliated with Rubella

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16Gene Ontology
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Cellular components related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.0CALR, HLA-DPB1
2extracellular spaceGO:0056158.8CD40LG, CALR, IL12A, TPO

Biological processes related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430669.3CD40LG, CAT, UNG
2hydrogen peroxide catabolic processGO:0427449.2CAT, TPO

Products for genes affiliated with Rubella

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rubella

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet