MCID: RBL001
MIFTS: 59

Rubella malady

Infectious diseases category

Summaries for Rubella

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Rubella is an infection caused by a virus. it is usually mild with fever and a rash. about half of the people who get rubella do not have symptoms. if you do get them, symptoms may include a rash that starts on the face and spreads to the body mild fever aching joints, especially in young women swollen glands rubella is most dangerous for a pregnant woman's baby. it can cause miscarriage or birth defects. rubella spreads when an infected person coughs or sneezes. people without symptoms can still spread it. there is no treatment, but the measles-mumps-rubella (mmr) vaccine can prevent it. centers for disease control and prevention

MalaCards: Rubella, also known as german measles, is related to measles and hepatitis, and has symptoms including fever, lymphadenopathy and joint pains. An important gene associated with Rubella is CD40LG (CD40 ligand), and among its related pathways are Regulation of thyroid hormone activity and Immune response IL-22 signaling pathway. The compounds rubella and gliadin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in rubella virus, which is transmitted by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted by congenital method. the infection has symptom rash on the face which spreads to the trunk and limbs, has symptom fever, has symptom lymphadenopathy, has symptom joint pains, has symptom headache, and has symptom conjunctivitis.

CDC:3 Turns out that this pipsqueak has a much more sinister goal than just making big people a little bit sick—it's after babies…

Wikipedia:63 Rubella, also known as German measles or three-day measles, is a disease caused by the rubella virus.... more...

Aliases & Classifications for Rubella

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Related Diseases for Rubella

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Rubella via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1measles31.6RNPC3, CD40LG
2hepatitis30.6CD40LG, CAT
3influenza30.5CALR, RNPC3
4hepatitis b30.5IFNA21, TRIM22, RNPC3
5encephalitis30.5ZNF175, GAD2, CAT
6diabetes mellitus30.4CD40LG, GAD2, CAT, CALR
7toxoplasmosis30.4CD40LG
8uveitis30.3RNPC3
9thyroiditis30.3TPO, GAD2
10herpes simplex30.2UNG
11leukemia30.1IL3RA, CD40LG, TRIM5, CAT
12hepatitis c29.9C1QBP, IFNA21, TRIM22, CD40LG, RNPC3
13vasculitis29.9CD40LG
14tuberculosis29.7TPO, CALR
15schizophrenia29.7GAD2
16mumps11.0
17congenital rubella10.4
18aseptic meningitis10.3
19meningitis10.3
20tetanus10.3
21cataract10.3
22diphtheria10.2
23hepatitis a10.2
24exanthem10.2
25pertussis10.2
26myelitis10.2
27arthritis10.2
28multiple sclerosis10.2
29poliomyelitis10.2
30purpura10.2
31chickenpox10.1
32autism spectrum disorder10.1
33iridocyclitis10.1
34syphilis10.1
35subacute sclerosing panencephalitis10.1
36acute leukemia10.1
37hemolytic anemia10.1
38hypothyroidism10.1
39lymphoblastic leukemia10.1
40autoimmune thyroiditis10.0TPO
41lupus erythematosus10.0CD40LG, CALR
42graves' disease10.0TPO, GAD2
43celiac disease10.0TPO, HLA-DPA1, CALR
44sarcoma10.0TPO
45hypersensitivity reaction type ii disease10.0GAD2
46mixed connective tissue disease10.0RNPC3
47sjogren's syndrome10.0RNPC3, CD40LG, CALR
48rheumatoid arthritis10.0CALR, HLA-DPB1, CD40LG, RNPC3
49myasthenia gravis10.0HLA-DPB1
50endocarditis10.0C1QBP

Graphical network of the top 20 diseases related to Rubella:



Diseases related to rubella

Clinical Features for Rubella

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • fever
  • lymphadenopathy
  • joint pains
  • headache
  • conjunctivitis
  • rash on the face which spreads to the trunk

Drugs & Therapeutics for Rubella

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rubella

Drug clinical trials:

Search ClinicalTrials for Rubella

Search NIH Clinical Center for Rubella

Search CenterWatch for Rubella

Genetic Tests for Rubella

About this section

Anatomical Context for Rubella

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Rubella:

32
Skin, Testes, T cells, Thyroid, Eye, Brain, Endothelial, Placenta, Breast, Salivary gland, Liver, Heart, Lymph node, Whole blood, Bone

FMA organs/tissues related to Rubella:

14
Skin

Animal Models for Rubella or affiliated genes

About this section

Publications for Rubella

About this section
Sources:
50PubMed
See all sources

Articles related to Rubella:

(show top 50)    (show all 1065)
idTitleAuthorsYear
1
Causes of a nationwide rubella outbreak in Japan, 2012-2013. (24029626)
2014
2
Progress in the elimination of measles and congenital rubella in Central Italy. (23292174)
2013
3
Antibody persistence and booster vaccination of a fully liquid hexavalent vaccine coadministered with measles/mumps/rubella and varicella vaccines at 15-18 months of age in healthy South African infants. (23538523)
2013
4
Rubella and congenital rubella syndrome control and elimination a89 global progress, 2012. (24367837)
2013
5
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2012. (24304830)
2013
6
Rubella vaccination success in Australia: no time for complacency. (23163678)
2012
7
Rubella associated with hemophagocytic syndrome. First report in a male and review of the literature. (22973494)
2012
8
Molecular analysis of rubella virus in travelers suspected of measles infection in SALo Paulo, Brazil. (23090221)
2012
9
Rubella encephalitis. (22019669)
2011
10
Rubella diagnostic issues in Canada. (21954263)
2011
11
Advocacy and resource mobilization for rubella elimination in Guatemala. (21954253)
2011
12
Immunogenicity and safety of a measles-mumps-rubella-varicella vaccine following a 4-week or a 12-month interval between two doses. (21382484)
2011
13
Do European doctors support measles, mumps, rubella vaccination programmes enough? (21968421)
2011
14
Pregnancy outcomes following rubella vaccination: a prospective study in the state of Rio de Janeiro, Brazil, 2001-2002. (21954273)
2011
15
Elimination of rubella and congenital rubella syndrome in the Americas. (21954249)
2011
16
Development of a novel TaqMan real-time PCR assay for detecting rubella virus RNA. (20580632)
2010
17
Seroprevalence of immunity to rubella in pregnant women. (21197723)
2010
18
Seropositivity rates for toxoplasmosis, rubella, syphilis, cytomegalovirus, hepatitis and HIV among pregnant women receiving care at a public health service, SALo Paulo state, Brazil. (21340301)
2010
19
Hypersensitivity reactions following measles-mumps-rubella vaccine and dextran-specific IgG response. (20605313)
2010
20
Rubella seroprevalence among women aged 15-39 years in Morocco. (19731768)
2009
21
Recent speciation of Capsella rubella from Capsella grandiflora, associated with loss of self-incompatibility and an extreme bottleneck. (19307580)
2009
22
Low immunity to measles and rubella among female guest workers, northern Mariana Islands. (19891896)
2009
23
Safety and immunogenicity of a measles-mumps-rubella-varicella vaccine given as a second dose in children up to six years of age. (19428882)
2009
24
Childhood lichen planus after simultaneous measles-mumps-rubella and diphtheria-tetanus-pertussis-polio vaccinations. (18081897)
2008
25
A new challenge for Europe: introducing a pediatric quadrivalent vaccine for measles, mumps, rubella, and varicella. (18162247)
2007
26
Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus. (17854033)
2007
27
Accelerated control of rubella and prevention of congenital rubella syndrome, WHO Region of the Americas. (12696443)
2003
28
Rubella and congenital rubella syndrome in Japan: epidemiological problems. (12944671)
2003
29
Risk analysis of aseptic meningitis after measles-mumps-rubella vaccination in Korean children by using a case-crossover design. (12522023)
2003
30
Congenital rubella syndrome in Haiti (Short communication). (12431359)
2002
31
An epidemic of congenital rubella in Barbados. (11064778)
2000
32
Improved dysgammaglobulinaemia in congenital rubella syndrome after immunoglobulin therapy: correlation with CD154 expression. (11039132)
2000
33
Gianotti-Crosti syndrome after measles, mumps and rubella vaccination. (9990393)
1998
34
Congenital rubella reinfection in a mother with anti-cardiolipin and anti-platelet antibodies. (9041611)
1997
35
Galactosemia with rubella infection. (9567560)
1997
36
Surveillance of congenital rubella syndrome and other rubella-associated adverse pregnancy outcomes. (8680371)
1996
37
Neuroimaging findings (ultrasonography, CT, MRI) in 3 infants with congenital rubella syndrome. (1815171)
1991
38
Unusual encephaloclastic lesions with paraventricular calcification in congenital rubella. (2047168)
1991
39
Congenital rubella in babies of south Asian women in England and Wales. (3107714)
1987
40
Congenital rubella syndrome. (3762485)
1986
41
Epidemiology of rubella and congenital rubella infection in Israel, a country with a selective immunization program. (4001732)
1985
42
Preventing the congenital rubella syndrome by vaccinating women at risk. (6861052)
1983
43
Use of the direct haemolysis-in-gel test for rubella antibodies in the Icelandic prevention programme for congenital rubella. (6355196)
1983
44
Congenital rubella following inapparent rubella infection. (7106886)
1982
45
The devastating effects of congenital rubella. (106205)
1979
46
Follow-up report on autism in congenital rubella. (576606)
1977
47
Progressive rubella panencephalitis. Late onset after congenital rubella. (1117960)
1975
48
Epidemiology of congenital rubella syndrome. The role of maternal parity. (1173441)
1975
49
Impaired cellular immunity to rubella virus in congenital rubella. (4808855)
1974
50
Transient arthritis after rubella vaccination. (5794817)
1969

Genetic Variations for Rubella

About this section

Expression for genes affiliated with Rubella

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rubella

Search GEO for disease gene expression data for Rubella.

Pathways for genes affiliated with Rubella

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
See all sources

Pathways related to Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TPO, GAD2
210.4IL12A, HLA-DPB1, HLA-DPA1
3
Hide members
10.4HLA-DPA1, HLA-DPB1, CD40LG, IL12A
410.4TPO, IL3RA, IL12A, IFNA21
510.4IFNA21, HLA-DPA1, HLA-DPB1, IL12A
6
Hide members
10.4TPO, IL3RA, IL12A, CD40LG, IFNA21
7
Hide members
10.4IFNA21, HLA-DPA1, HLA-DPB1, IL3RA
8
Hide members
10.4CALR, IFNA21, HLA-DPA1, HLA-DPB1, CD40LG, IL3RA
9
Hide members
10.3C1QBP, IFNA21, HLA-DPA1, HLA-DPB1, IL12A
10
Hide members
10.3IL12A, CD40LG, HLA-DPB1, HLA-DPA1, GAD2, IFNA21

Compounds for genes affiliated with Rubella

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Rubella according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1rubella4410.7CD40LG, CALR
2gliadin4410.7TPO, CD40LG, GAD2, CALR
3hydrogen44 2411.7CALR, AGA, RNPC3, TPO
4dpa 14410.6HLA-DPB1, HLA-DPA1
5oligonucleotide4410.6CALR, UNG, GAD2, HLA-DPB1, RNPC3, TPO
6iron44 2411.6CALR, CAT, NDUFB4, RNPC3, TPO
7glutamate4410.5CALR, UNG, GAD2, HLA-DPB1, CD40LG, TPO
8guaiacol44 2411.5TPO, CAT
9adenylate4410.5CALR, TRIM22, CD40LG, RNPC3, TPO
10biotin44 11 2412.4RNPC3, CD40LG, C1QBP
11cysteine4410.4CALR, CAT, GAD2, AGA, CD40LG, TPO
12deoxyribose44 2411.3UNG, CAT
13acetylcholine44 49 28 11 2414.1GAD2, TRIM22, CD40LG, TPO

GO Terms for genes affiliated with Rubella

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579410.4CAT, LST1, TRIM5, TRIM22, CALR
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-DPB1, HLA-DPA1, CALR
3MHC class II protein complexGO:04261310.1HLA-DPB1, HLA-DPA1

Biological processes related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160710.5ZNF175, TRIM22, TRIM5, IFNA21
2positive regulation of dendritic cell chemotaxisGO:200051010.4C1QBP, CALR
3immune responseGO:00695510.4C1QBP, LST1, HLA-DPA1, TRIM22, IL12A
4modulation by virus of host morphology or physiologyGO:01904810.4TRIM22, TRIM5, UNG, C1QBP
5positive regulation of substrate adhesion-dependent cell spreadingGO:190002610.3CALR, C1QBP
6protein trimerizationGO:07020610.1TRIM22, TRIM5

Molecular functions related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1q bindingGO:00184910.4CALR, C1QBP

Products for genes affiliated with Rubella

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rubella

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet