MCID: RBL001
MIFTS: 53

Rubella malady

Rare diseases, Infectious diseases, Bone diseases, Skin diseases, Fetal diseases, Neuronal diseases categories

Summaries for Rubella

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MedlinePlus:32 Rubella is an infection caused by a virus. it is usually mild with fever and a rash. about half of the people who get rubella do not have symptoms. if you do get them, symptoms may include a rash that starts on the face and spreads to the body mild fever aching joints, especially in young women swollen glands rubella is most dangerous for a pregnant woman's baby. it can cause miscarriage or birth defects. rubella spreads when an infected person coughs or sneezes. people without symptoms can still spread it. there is no treatment, but the measles-mumps-rubella (mmr) vaccine can prevent it. centers for disease control and prevention

MalaCards based summary: Rubella, also known as german measles, is related to encephalitis and tetanus, and has symptoms including rash on the face which spreads to the trunk, fever and lymphadenopathy. An important gene associated with Rubella is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Malaria. The compounds rubella and cytidine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes, and related mouse phenotypes are nervous system and immune system.

Disease Ontology:9 A viral infectious disease that results in infection located in skin, has material basis in rubella virus, which is transmitted by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted by congenital method. the infection has symptom rash on the face which spreads to the trunk and limbs, has symptom fever, has symptom lymphadenopathy, has symptom joint pains, has symptom headache, and has symptom conjunctivitis.

CDC:3 Rubella is a contagious disease caused by a virus. It is also called German measles or three-day measles. But don't confuse rubella with measles, which is sometimes called rubeola. The two diseases have similar features, including a red rash, but they are caused by different viruses...

Wikipedia:63 Rubella, also known as German measles or three-day measles, is a disease caused by the rubella virus.... more...

Aliases & Classifications for Rubella

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Related Diseases for Rubella

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Graphical network of the top 20 diseases related to Rubella:



Diseases related to rubella

Symptoms for Rubella

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Symptoms:

 9
  • rash on the face which spreads to the trunk
  • fever
  • lymphadenopathy
  • joint pains
  • headache
  • conjunctivitis

Drugs & Therapeutics for Rubella

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Drug clinical trials:

Search ClinicalTrials for Rubella

Search NIH Clinical Center for Rubella

Genetic Tests for Rubella

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Anatomical Context for Rubella

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MalaCards organs/tissues related to Rubella:

31
Skin, Testes, T cells, Thyroid, Eye, Brain, Lymph node, Endothelial, Bone, Whole blood, Heart, Liver, Salivary gland, Breast, Placenta

FMA organs/tissues related to Rubella:

14
Skin

Animal Models for Rubella or affiliated genes

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MGI Mouse Phenotypes related to Rubella:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4AGA, CD40LG, GAD2, CALR, UNG
2MP:00053878.3UNG, TPO, IL12A, GAD2, CD40LG
3MP:00053848.0UNG, CALR, CAT, CD40LG, AGA
4MP:00053767.0AGA, UNG, TPO, IL12A, CALR, CAT
5MP:00107686.9UNG, TPO, IL12A, CALR, CAT, GAD2

Publications for Rubella

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Articles related to Rubella:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
Seroprevalence of measles, mumps and rubella among young adults, after 20A years of universal two-dose MMR vaccination in Israel. (25891446)
2015
2
Measles-Mumps-Rubella-Varicella Combination Vaccine (ProQuad(Ar)): A Guide to Its Use in Children in the EU. (25732634)
2015
3
Mumps antibody response in young adults after a third dose of measles-mumps-rubella vaccine. (25734162)
2014
4
Decline of varicella vaccination in German surveillance regions after recommendation of separate first-dose vaccination for varicella and measles-mumps-rubella. (24412300)
2014
5
Investigation of an outbreak of hypersensitivity-type reactions during the 2004 national measles-mumps-rubella vaccination campaign in Brazil. (23246259)
2013
6
Influence of Vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan. (24270137)
2013
7
Magnetic resonance imaging findings in a case of congenital rubella encephalitis. (24489572)
2013
8
Rubella in Poland in 2011. (24040714)
2013
9
The importance of fundus eye testing in rubella-induced deafness. (23911114)
2013
10
Congenital rubella syndrome: a review of laboratory data from 2002 to 2011. (24050074)
2013
11
Enabling implementation of the Global Vaccine Action Plan: developing investment cases to achieve targets for measles and rubella prevention. (23598476)
2013
12
Congenital rubella syndrome and left pulmonary artery sling. (22298614)
2012
13
An outbreak of rubella in the Federation of Bosnia and Herzegovina between December 2009 and May 2010 indicates failure to vaccinate during wartime (1992-1995). (21524344)
2012
14
Letter to the editor: commitment needed for the prevention of congenital rubella syndrome in Europe. (22433598)
2012
15
Pityriasis lichenoides et varioliformis acuta: a rare association with the measles, mumps and rubella vaccine. (23157791)
2012
16
Rubella vaccines: WHO position paper--recommendations. (21930175)
2011
17
Development of microsatellite markers in Capsella rubella and Capsella bursa-pastoris (Brassicaceae). (21700797)
2011
18
Congenital rubella syndrome and autism spectrum disorder prevented by rubella vaccination--United States, 2001-2010. (21592401)
2011
19
Application of new assays for rapid confirmation and genotyping of isolates of rubella virus. (21108356)
2011
20
Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses. (21441098)
2011
21
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. (20001730)
2010
22
Surveillance and control of rubella in the republic of Korea from 2001 to 2009: the necessity for enhanced surveillance to monitor congenital rubella syndrome. (24159436)
2010
23
Development of a novel TaqMan real-time PCR assay for detecting rubella virus RNA. (20580632)
2010
24
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
25
Could the United States experience rubella outbreaks as a result of vaccine refusal and disease importation? (21150305)
2010
26
Closer look at autism and the measles-mumps-rubella vaccine. (21071320)
2010
27
A measles and rubella (MR) catch-up vaccination campaign in an Egyptian University: vaccine uptake and knowledge and attitudes of students. (20797454)
2010
28
A relapse of systemic type juvenile idiopathic arthritis after a rubella vaccination in a patient during a long-term remission period. (19576941)
2009
29
Chlamydia trachomatis and rubella antibodies in women with full-term deliveries and women with abortion in Baghdad. (20218131)
2009
30
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. (19007835)
2009
31
Development of the rubella vaccine and vaccination strategy in Japan. (19366581)
2009
32
Humoral immune response to primary rubella virus infection. (16522781)
2006
33
Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)
2005
34
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy. (15717298)
2005
35
The risk of aseptic meningitis associated with the Leningrad-Zagreb mumps vaccine strain following mass vaccination with measles-mumps-rubella vaccine, Rio Grande do Sul, Brazil, 1997. (12435771)
2002
36
Previous exposure to measles, mumps, and rubella--but not vaccination during adolescence--correlates to the prevalence of pancreatic and thyroid autoantibodies. (10390298)
1999
37
Use of PCR for prenatal and postnatal diagnosis of congenital rubella. (8576339)
1995
38
Detection of rubella virus-specific immunoglobulin G (IgG), IgM, and IgA antibodies by immunoblot assays. (1572968)
1992
39
Rubella surveillance to december 1990: a joint report from the PHLS and National Congenital Rubella Surveillance Programme. (1669769)
1991
40
Development of a highly specific and sensitive rubella immunoglobulin M antibody capture enzyme immunoassay that uses enzyme-labeled antigen. (2185260)
1990
41
Congenital rubella syndrome in Malaysia. (3831727)
1985
42
Birth and death of congenital rubella syndrome. (6700106)
1984
43
The HLA system in congenital rubella patients with and without diabetes. (6959935)
1982
44
Congenital rubella syndrome: a continuing problem. (6799666)
1982
45
Congenital rubella, insulitis, and diabetes mellitus in an infant. (6112424)
1981
46
Keratoconus and acute hydrops in mentally retarded patients with congenital rubella syndrome. (7468739)
1981
47
Impaired cell-mediated immune response in patients with congenital rubella: correlation with gestational age at time of infection. (386238)
1979
48
The devastating effects of congenital rubella. (106205)
1979
49
Nuclear and cytoplasmic immunofluorescence in the cerebrospinal fluid cells from a neonate with congenital rubella. (347227)
1977
50
Congenital rubella--an encapsulated review. (960007)
1976

Variations for Rubella

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Expression for genes affiliated with Rubella

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Search GEO for disease gene expression data for Rubella.

Pathways for genes affiliated with Rubella

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Pathways related to Rubella according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD40LG, UNG
29.6CD40LG, IL12A
3
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.1IL12A, HLA-DPB1
4
Show member pathways
8.8HLA-DPB1, IL12A, CD40LG
5
Show member pathways
7.6CD40LG, GAD2, CALR, IL12A, TPO, HLA-DPB1

Compounds for genes affiliated with Rubella

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Rubella according to GeneCards Suite gene sharing:

(show all 36)
idCompoundScoreTop Affiliating Genes
1rubella4310.2CD40LG, CALR
2cytidine43 24 1212.1CD40LG, UNG
3valproate4310.1CD40LG, CALR
4cardiolipin43 1211.0TPO, CD40LG
5deoxyribose43 2411.0CAT, UNG
6maltose43 1211.0GAD2, TPO
7125i4310.0GAD2, TPO
8tert-butylhydroperoxide439.9CALR, CAT
9mycophenolate mofetil43 49 1211.9IL12A, CD40LG
10hypoxanthine43 24 1211.9CAT, UNG
11guaiacol43 2410.9CAT, TPO
12Hydrogen peroxide249.8CAT, TPO
13c-peptide439.8TPO, GAD2
14selenium43 2410.7CAT, TPO
15tetracycline43 1210.7CD40LG, TPO
16polysaccharide439.7CD40LG, CALR, TPO
17acetylcholine43 49 28 24 1213.6TPO, GAD2, CD40LG
18n acetylcysteine439.6CD40LG, CAT, CALR
19levodopa43 1210.5GAD2, CAT
20ascorbic acid43 2410.5TPO, CAT, CD40LG
21lactate439.5CALR, CAT, CD40LG
22adenylate439.4TPO, CALR, CD40LG
23superoxide43 2410.4CAT, CALR, UNG
24uric acid43 2410.4TPO, CAT
25iron43 2410.4CAT, CALR, TPO
26gliadin439.3CD40LG, GAD2, CALR, TPO
27aspartate439.2AGA, CD40LG, TPO
28cycloheximide439.2CAT, TPO, UNG
29n-acetylglucosamine439.2CALR, AGA
30h2o2439.2UNG, TPO, CALR, CAT
31threonine439.1AGA, GAD2, CALR, UNG
32nitric oxide43 24 1211.1TPO, CALR, CAT, GAD2
33hydrogen43 249.7UNG, TPO, CALR, GAD2, AGA
34oligonucleotide438.5HLA-DPB1, UNG, TPO, CALR, GAD2
35cysteine438.2TPO, CALR, CAT, GAD2, CD40LG, AGA
36glutamate438.2HLA-DPB1, UNG, TPO, CALR, GAD2, CD40LG

GO Terms for genes affiliated with Rubella

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Cellular components related to Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.0CALR, HLA-DPB1
2extracellular spaceGO:00056158.8CD40LG, CALR, IL12A, TPO

Biological processes related to Rubella according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:00430669.3CD40LG, CAT, UNG
2hydrogen peroxide catabolic processGO:00427449.2CAT, TPO

Products for genes affiliated with Rubella

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Rubella

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet