MCID: RBL001
MIFTS: 55

Rubella malady

Infectious category

Summaries for Rubella

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Rubella is an infection caused by a virus. it is usually mild with fever and a rash. about half of the people who get rubella do not have symptoms. if you do get them, symptoms may include a rash that starts on the face and spreads to the body mild fever aching joints, especially in young women swollen glands rubella is most dangerous for a pregnant woman's baby. it can cause miscarriage or birth defects. rubella spreads when an infected person coughs or sneezes. people without symptoms can still spread it. there is no treatment, but the measles-mumps-rubella (mmr) vaccine can prevent it. centers for disease control and prevention

MalaCards: Rubella, also known as german measles, is related to measles and hepatitis c, and has symptoms including rash on the face which spreads to the trunk, fever and lymphadenopathy. An important gene associated with Rubella is CD40LG (CD40 ligand), and among its related pathways are Regulation of thyroid hormone activity and Immune response IL-22 signaling pathway. The compounds rubella and gliadin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and whole blood.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in rubella virus, which is transmitted by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted by congenital method. the infection has symptom rash on the face which spreads to the trunk and limbs, has symptom fever, has symptom lymphadenopathy, has symptom joint pains, has symptom headache, and has symptom conjunctivitis.

Wikipedia:64 Rubella, also known as German measles or three-day measles, is a disease caused by the rubella virus.... more...

Aliases & Classifications for Rubella

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
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Related Diseases for Rubella

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Rubella:



Diseases related to rubella

Clinical Features for Rubella

Sources:
8Disease Ontology
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Symptoms:

8 (show all 6)
  • rash on the face which spreads to the trunk
  • fever
  • lymphadenopathy
  • joint pains
  • headache
  • conjunctivitis

Drugs & Therapeutics for Rubella

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rubella

Drug clinical trials:

Search ClinicalTrials for Rubella

Search NIH Clinical Center for Rubella

Search CenterWatch for Rubella

Genetic Tests for Rubella

Anatomical Context for Rubella

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Rubella:

33
Skin, Whole blood, Lymph node, Brain, Heart, Liver, Thyroid, Salivary gland, Breast, Placenta, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal thyroid, Pancreatic islet

FMA organs/tissues related to Rubella:

14
Skin

Animal Models for Rubella or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Rubella

Sources:
51PubMed
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Articles related to Rubella:

(show top 50)    (show all 1065)
idTitleAuthorsYear
1
Is the MMR vaccination programme failing to protect women against rubella infection? (23953764)
2013
2
Rubella in Israel after the MMR vaccine: elimination or containment? (23447030)
2013
3
Evaluation of rubella IgG antibodies among women at marriage in kermanshah city, before and after mass vaccination. (24049618)
2013
4
New preventive strategy to eliminate measles, mumps and rubella from Europe based on the serological assessment of herd immunity levels in the population. (23417624)
2013
5
Burden of Congenital Rubella Syndrome (CRS) in India: a systematic review. (22700664)
2012
6
Analysis of subcellular G3BP redistribution during rubella virus infection. (21994324)
2012
7
Targeting rubella for elimination. (23354136)
2012
8
Rubella vaccines: WHO position paper--recommendations. (21930175)
2011
9
Sentinel phenotype for rubella embryopathy: time-space distribution in Brazil. (22031200)
2011
10
Seroprevalence survey of rubella infection in pregnancy at the University of Benin Teaching Hospital, Benin City, Nigeria. (21860127)
2011
11
Immunogenicity and safety of an inactivated hepatitis A vaccine when coadministered with measles-mumps-rubella and varicella vaccines in children less than 2 years of age. (21617573)
2011
12
Concentration and purification of rubella virus using monolithic chromatographic support. (21440513)
2011
13
Rubella vaccination of unknowingly pregnant women during 2006 mass campaign in Argentina. (21954276)
2011
14
Measles, mumps, rubella (MMR) vaccine - a reply (2). (22298222)
2011
15
Assessment of humoral and cell-mediated immune response to measles-mumps-rubella vaccine viruses among patients with asthma. (21708062)
2010
16
Rubella seroepidemiology and catch-up immunization among pregnant women in Taiwan: comparison between women born in Taiwan and immigrants from six countries in Asia. (20064993)
2010
17
Prevalence of rubella IgG antibodies among Syrian females of childbearing age. (20714700)
2010
18
Seroprevalence of rubella in female migrant factory workers in Shenzhen, China. (20937319)
2010
19
Serum levels of rubella-specific antibodies in Swedish women following three decades of vaccination programmes. (19925909)
2010
20
A fatal case of disseminated tuberculosis coincident with measles-rubella vaccination. (21191455)
2010
21
Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. (20202055)
2010
22
Persistence of mumps antibodies after 2 doses of measles-mumps-rubella vaccine. (19113988)
2009
23
Seroprevalence of antibodies to measles, mumps, and rubella among Thai population: evaluation of measles/MMR immunization programme. (19248651)
2009
24
The strategy for prevention of measles and rubella prevalence with measles-rubella (MR) vaccine in Japan. (19366578)
2009
25
Congenital rubella syndrome in infants of women vaccinated during or just before pregnancy with measles-rubella vaccine. (18765873)
2008
26
Factors associated with uptake of measles, mumps, and rubella vaccine (MMR) and use of single antigen vaccines in a contemporary UK cohort: prospective cohort study. (18309964)
2008
27
Seroprevalence of measles, mumps, rubella and varicella among staff of a hospital in Riyadh, Saudi Arabia. (18410713)
2007
28
Frontal-dominant white matter lesions following congenital rubella and cytomegalovirus infection. (16602852)
2006
29
Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (15655774)
2005
30
Rubella outbreak in an unvaccinated religious community in the Netherlands leads to cases of congenital rubella syndrome. (16794286)
2005
31
Preventing congenital rubella infection in the European Region of WHO: 2010 target. (15192255)
2004
32
Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. (12824690)
2003
33
Outbreak of aseptic meningitis associated with mass vaccination with a urabe-containing measles-mumps-rubella vaccine: implications for immunization programs. (10707922)
2000
34
Rubella infection in adult onset Still's disease. (10885978)
2000
35
Idiopathic keratoconus in a patient with congenital rubella syndrome. (9924313)
1998
36
ACIP issues recommendations to eliminate measles, rubella and congenital rubella syndrome and to control mumps. (9824963)
1998
37
Congenital rubella in the Asian community in Britain. (2098023)
1990
38
Sonography of subependymal cysts in congenital rubella syndrome. (3063530)
1988
39
Children at high risk of diabetes mellitus: New York studies of families with diabetes and of children with congenital rubella syndrome. (3074654)
1988
40
Congenital rubella syndrome in the Ryukyu Islands: birth-weight and physical status before two years of age. (3144841)
1987
41
Rubella and congenital rubella syndrome--United States, 1983-1984. (6433171)
1984
42
Epidemiology of prenatal infections: an extension of the congenital rubella model. (6648116)
1983
43
Congenital rubella syndrome: a continuing problem. (6799666)
1982
44
Preventive medicine and public health-epitomes of progress: rubella vaccine and congenital rubella syndrome prevention. (18749001)
1982
45
Dermatoglyphics in congenital rubella syndrome with congenital heart disease. (731832)
1978
46
Rubella 1974 and its aftermath, congenital rubella syndrome. (1253045)
1976
47
Dysgammaglobulinaemia and temporary immune paresis in a case of congenital rubella. (1137527)
1975
48
Letter: Congenital rubella and autistic behavior. (1134536)
1975
49
Viral persistence in congenital rubella. (4608455)
1974
50
New thoughts on infectious diseases. III. Scarlet fever, measles and rubella. (13153603)
1954

Genetic Variations for Rubella

Expression for genes affiliated with Rubella

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rubella

Search GEO for disease gene expression data for Rubella.

Pathways for genes affiliated with Rubella

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN
See all sources

Pathways related to Rubella according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TPO, GAD2
210.4IL12A, HLA-DPB1, HLA-DPA1
3
Hide members
10.4HLA-DPA1, HLA-DPB1, CD40LG, IL12A
410.4TPO, IL3RA, IL12A, IFNA21
510.4IFNA21, HLA-DPA1, HLA-DPB1, IL12A
6
Hide members
10.4TPO, IL3RA, IL12A, CD40LG, IFNA21
7
Hide members
10.4IFNA21, HLA-DPA1, HLA-DPB1, IL3RA
8
Hide members
10.4CALR, IFNA21, HLA-DPA1, HLA-DPB1, CD40LG, IL3RA
9
Hide members
10.3C1QBP, IFNA21, HLA-DPA1, HLA-DPB1, IL12A
10
Hide members
10.3IL12A, CD40LG, HLA-DPB1, HLA-DPA1, GAD2, IFNA21

Compounds for genes affiliated with Rubella

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Rubella according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1rubella4510.7CD40LG, CALR
2gliadin4510.7TPO, CD40LG, GAD2, CALR
3hydrogen45 2411.7CALR, AGA, RNPC3, TPO
4dpa 14510.6HLA-DPB1, HLA-DPA1
5oligonucleotide4510.6CALR, UNG, GAD2, HLA-DPB1, RNPC3, TPO
6iron45 2411.6CALR, CAT, NDUFB4, RNPC3, TPO
7glutamate4510.5CALR, UNG, GAD2, HLA-DPB1, CD40LG, TPO
8guaiacol45 2411.5TPO, CAT
9adenylate4510.5CALR, TRIM22, CD40LG, RNPC3, TPO
10biotin45 11 2412.4RNPC3, CD40LG, C1QBP
11cysteine4510.4CALR, CAT, GAD2, AGA, CD40LG, TPO
12deoxyribose45 2411.3UNG, CAT
13acetylcholine45 50 29 11 2414.1GAD2, TRIM22, CD40LG, TPO

GO Terms for genes affiliated with Rubella

Sources:
16Gene Ontology
See all sources

Cellular components related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579410.4CAT, LST1, TRIM5, TRIM22, CALR
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.3HLA-DPB1, HLA-DPA1, CALR
3MHC class II protein complexGO:04261310.1HLA-DPB1, HLA-DPA1

Biological processes related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:05160710.5ZNF175, TRIM22, TRIM5, IFNA21
2positive regulation of dendritic cell chemotaxisGO:200051010.4C1QBP, CALR
3immune responseGO:00695510.4C1QBP, LST1, HLA-DPA1, TRIM22, IL12A
4modulation by virus of host morphology or physiologyGO:01904810.4TRIM22, TRIM5, UNG, C1QBP
5positive regulation of substrate adhesion-dependent cell spreadingGO:190002610.3CALR, C1QBP
6protein trimerizationGO:07020610.1TRIM22, TRIM5

Molecular functions related to Rubella according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement component C1q bindingGO:00184910.4CALR, C1QBP

Products for genes affiliated with Rubella

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rubella

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet