MCID: SCR024
MIFTS: 46

Sacrococcygeal Teratoma malady

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Summaries for Sacrococcygeal Teratoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  it occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  though it is usually benign, there is a possibility that the teratoma could become malignant.  as such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  if not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  studies have found that sacrococcygeal teratomas recur in up to 22% of cases. last updated: 10/18/2013

MalaCards: Sacrococcygeal Teratoma is related to teratoma and endodermal sinus tumor. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are G protein signaling H RAS regulation pathway and Human Early Embryo Development. The compounds tachyplesin i and oestriol have been mentioned in the context of this disorder. Affiliated tissues include heart, pituitary and eye, and related mouse phenotypes are digestive/alimentary and normal.

Wikipedia:65 Sacrococcygeal teratoma (SCT) is a teratoma (a kind of tumor) located at the base of the coccyx... more...

Aliases & Classifications for Sacrococcygeal Teratoma

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

sacrococcygeal teratoma 43 62


Related Diseases for Sacrococcygeal Teratoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to sacrococcygeal teratoma

Symptoms for Sacrococcygeal Teratoma

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Drugs & Therapeutics for Sacrococcygeal Teratoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sacrococcygeal Teratoma

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Genetic Tests for Sacrococcygeal Teratoma

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Anatomical Context for Sacrococcygeal Teratoma

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33MalaCards
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MalaCards organs/tissues related to Sacrococcygeal Teratoma:

33
Heart, Pituitary, Eye, Bone, Liver, Lung, Placenta

Animal Models for Sacrococcygeal Teratoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sacrococcygeal Teratoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8GDNF, GFAP, MNX1, POU5F1, RET
2MP:00028738.6RET, JUN, POU5F1, MNX1, GFAP
3MP:00053898.4GDNF, AFP, POU5F1, RET, PCNA, CGA
4MP:00053868.2GDNF, GFAP, AFP, MNX1, POU5F1, JUN
5MP:00036318.1GDNF, GFAP, MNX1, POU5F1, JUN, RET
6MP:00053978.1GDNF, MNX1, POU5F1, JUN, RET, PCNA
7MP:00053787.9GDNF, GFAP, MNX1, JUN, RET, PCNA
8MP:00053847.9GDNF, GFAP, MNX1, POU5F1, JUN, NANOG
9MP:00053877.8GDNF, GFAP, MNX1, JUN, RET, PCNA
10MP:00053797.8CGA, GDNF, AFP, MNX1, POU5F1, JUN
11MP:00107687.1GDNF, GFAP, AFP, MNX1, POU5F1, JUN

Publications for Sacrococcygeal Teratoma

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52PubMed
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Articles related to Sacrococcygeal Teratoma:

(show top 50)    (show all 379)
idTitleAuthorsYear
1
The long-term psychosocial outcomes following excision of sacrococcygeal teratoma: a national study. (24277662)
2013
2
Two cases of prenatally diagnosed sacrococcygeal teratoma type I with different clinical features. (23751044)
2013
3
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. (24057924)
2013
4
Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: a 25-year experience at a single institution. (23845611)
2013
5
Large sacrococcygeal teratoma hindering vaginal delivery attempted at home. (22866184)
2012
6
Echocardiographic risk stratification of fetuses with sacrococcygeal teratoma and twin-reversed arterial perfusion. (22086180)
2011
7
Partial trisomy 3q in a child with sacrococcygeal teratoma and Cornelia de Lange syndrome phenotype. (21848013)
2011
8
Foetal sacrococcygeal teratoma: extremes in clinical presentation. (21731981)
2011
9
Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre. (19184053)
2009
10
Sacrococcygeal teratoma in an adult female Nigerian. (19253526)
2008
11
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
12
Prenatal diagnosis of type I sacrococcygeal teratoma and its management. (18581776)
2008
13
Corticotrophin-dependent Cushing syndrome due to Sacrococcygeal Teratoma detected by [18F]fluorodeoxyglucose positron emission tomography. (18772458)
2008
14
Mature sacrococcygeal teratoma: case report. (19357734)
2008
15
Mirror syndrome associated with sacrococcygeal teratoma: a case report. (17465292)
2007
16
Neurogenic bladder dysfunction after sacrococcygeal teratoma resection. (16406929)
2006
17
Factors associated with recurrence and metastasis in sacrococcygeal teratoma. (17058315)
2006
18
Spontaneous rupture of fetal sacrococcygeal teratoma. (16912491)
2006
19
Management of sacrococcygeal teratoma of the fetus. (15321048)
2004
20
Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 cases. (14564114)
2003
21
Prenatal diagnosis of sacrococcygeal teratoma: a review of cases between 1993 and 2000. (12013082)
2002
22
Sacrococcygeal teratoma. (12415361)
2002
23
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
24
Successful intrauterine shunting of a sacrococcygeal teratoma (SCT) causing fetal bladder obstruction. (11746122)
2001
25
Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. (11051157)
2000
26
In utero fetal surgery for sacrococcygeal teratoma. (10848120)
2000
27
DNA ploidy analysis and cell proliferation in congenital sacrococcygeal teratomas. (10951360)
2000
28
Sacrococcygeal teratoma: a series of 19 cases with long-term follow-up. (10427491)
1999
29
Sacrococcygeal teratoma associated with a normal alpha-fetoprotein concentration. (9286870)
1997
30
Sacrococcygeal teratoma in Zaria, Nigeria: report of 47 cases. (8687206)
1995
31
Neonatal sacrococcygeal teratoma: prolonged survival after malignant relapse. (7703049)
1995
32
Lower urinary tract dysfunction in children with benign sacrococcygeal teratoma. (8254808)
1994
33
The association of sacrococcygeal teratoma with high anorectal and genital malformations. (8117204)
1994
34
Sacrococcygeal teratoma in children: a diagnostic challenge. (8291972)
1994
35
Anorectal function in adults operated for a benign sacrococcygeal teratoma. (8308684)
1993
36
Urological aspects of sacrococcygeal teratoma in children. (8345616)
1993
37
Prenatal ultrasonic appearance of the Klippel-Trenaunay-Weber syndrome mimicking sacrococcygeal teratoma with an elevated level of maternal serum hCG. (8177838)
1993
38
Sacrococcygeal teratoma and venous shunting through a tumor: biological evidence. (1734786)
1992
39
Sacrococcygeal teratoma in Sweden: a 10-year national retrospective study. (1282543)
1992
40
The management of prenatally diagnosed sacrococcygeal teratoma. (17587029)
1992
41
Neonatal sacrococcygeal teratoma: multiimaging modality assessment. (2193140)
1990
42
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
43
Sacrococcygeal teratoma: computed tomography evaluation. (3581859)
1987
44
Vaginal delivery impeded by a large fetal sacrococcygeal teratoma: anesthetic considerations. (3688507)
1987
45
Giant sacrococcygeal teratoma in an African child. (3829022)
1986
46
Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey-1973. (4843993)
1974
47
Sacrococcygeal teratoma. (14405262)
1959
48
Sacrococcygeal teratoma. (13533715)
1958
49
A case of congenital sacrococcygeal teratoma. (14886605)
1951
50
Sacrococcygeal teratoma with urinary retention. (15403717)
1950

Variations for Sacrococcygeal Teratoma

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Expression for genes affiliated with Sacrococcygeal Teratoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sacrococcygeal Teratoma

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Pathways for genes affiliated with Sacrococcygeal Teratoma

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50PathCards, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 12EMD Millipore
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Pathways related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7RET, GDNF
29.5POU5F1, NANOG
39.5NANOG, POU5F1
49.5NANOG, POU5F1
59.4CGA, JUN, AFP
6
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3RET, JUN, GDNF
79.3RET, JUN, GDNF
89.2NANOG, POU5F1, AFP
99.2AFP, JUN, PCNA
10
Show member pathways
9.2CGA, NANOG, POU5F1
11
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.1POU5F1, JUN, NANOG
129.0POU5F1, NANOG, CGB7
138.6RET, NANOG, JUN, POU5F1

Compounds for genes affiliated with Sacrococcygeal Teratoma

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1tachyplesin i4510.0PCNA, AFP
2oestriol459.8CGB7, CGA, AFP
3dbc-amp459.8CGA, GFAP, GDNF
4eosin459.8PCNA, GFAP
5vinblastine45 51 1111.8AFP, JUN, CGA
6ganciclovir45 1110.7GFAP, AFP, RET
7bleomycin45 1110.6CGB7, CGA, AFP
8silver459.6GFAP, AFP, PCNA
9mifepristone45 29 61 1112.5CGA, JUN, AFP
10polyethylene glycol459.5PCNA, AFP, GFAP
11kainate45 2910.4GDNF, GFAP, JUN
12actinomycin d459.4CGA, JUN, AFP, GDNF
13agar459.3GFAP, AFP, JUN, RET
14carboplatin45 51 1111.3AFP, MUC16, CGA
15thyroxine45 2410.2CGB7, CGA, PCNA, AFP
16b 723459.2PCNA, MUC16, AFP
17pd 98,059459.2GDNF, GFAP, JUN, RET
18methotrexate51 45 1111.2CGB7, CGA, PCNA, AFP
19forskolin45 51 1111.2GDNF, GFAP, JUN, CGA
20cytarabine45 51 1111.1PCNA, JUN, GFAP
21hematoxylin459.1PCNA, MUC16, GFAP
22cyclic amp45 2410.0GDNF, GFAP, JUN, RET, CGA
23glutamate459.0GDNF, GFAP, AFP, PCNA, CGA
24cyclophosphamide45 51 1110.9AFP, MUC16, PCNA, CGA
25butyrate458.8GFAP, AFP, JUN, RET, PCNA
26oligonucleotide458.8GDNF, AFP, JUN, RET, PCNA
27etoposide45 51 61 1111.8AFP, JUN, PCNA, CGA, CGB7
28paclitaxel45 51 1110.8PCNA, MUC16, AFP, GFAP
29genistein45 29 61 3 24 1113.8GDNF, GFAP, JUN, RET, PCNA
30oxygen45 249.7GDNF, GFAP, AFP, POU5F1, JUN
31aspartate458.7GDNF, GFAP, AFP, RET, PCNA, CGA
32dopamine45 29 24 1111.6GDNF, GFAP, POU5F1, RET, PCNA, CGA
33threonine458.4RET, MUC16, JUN, AFP, GFAP
34alanine458.4GDNF, GFAP, AFP, MNX1, RET, PCNA
35iron45 249.4GDNF, GFAP, AFP, MUC16
36creatinine458.3GDNF, GFAP, AFP, MUC16, PCNA, CGA
37cysteine458.2GDNF, GFAP, JUN, RET, PCNA, CGB7
38paraffin458.2GFAP, AFP, MUC16, RET, PCNA, CGA
39h2o2458.2GDNF, AFP, JUN, MUC16, PCNA, CGA
40dexamethasone45 51 29 1111.1GDNF, GFAP, AFP, JUN, MUC16, PCNA
41estradiol45 24 1110.1GFAP, AFP, MUC16, PCNA, CGA, CGB7
42lactate458.1GFAP, AFP, MUC16, PCNA, CGA, CGB7
43cisplatin45 51 61 1111.1GFAP, AFP, MUC16, PCNA, CGA, CGB7
44progesterone45 29 61 24 1112.1GFAP, AFP, MUC16, PCNA, CGA, CGB7
45serine457.9GDNF, GFAP, AFP, JUN, MUC16, RET
46estrogen457.8GDNF, GFAP, AFP, JUN, MUC16, PCNA
47tyrosine457.7GDNF, GFAP, AFP, JUN, MUC16, RET
48testosterone45 61 24 1110.7GFAP, AFP, MUC16, RET, PCNA, CGA
49retinoic acid45 248.4GDNF, GFAP, AFP, MNX1, POU5F1, JUN
50vegf457.1CGA, GDNF, GFAP, AFP, POU5F1, JUN

GO Terms for genes affiliated with Sacrococcygeal Teratoma

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16Gene Ontology
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Biological processes related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:0603959.8AFP, JUN
2enteric nervous system developmentGO:0484849.7RET, GDNF
3endodermal cell fate specificationGO:0017149.7NANOG, POU5F1
4somatic stem cell maintenanceGO:0350199.5NANOG, POU5F1
5gonad developmentGO:0084069.5CGA, NANOG
6neural crest cell migrationGO:0017559.4RET, GDNF
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5CGA, NANOG, JUN, POU5F1, GDNF

Products for genes affiliated with Sacrococcygeal Teratoma

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Sources for Sacrococcygeal Teratoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet