MCID: SCR024
MIFTS: 30

Sacrococcygeal Teratoma malady

Summaries for Sacrococcygeal Teratoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  it occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  though it is usually benign, there is a possibility that the teratoma could become malignant.  as such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  if not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  studies have found that sacrococcygeal teratomas recur in up to 22% of cases. last updated: 10/18/2013

MalaCards: Sacrococcygeal Teratoma is related to endodermal sinus tumor and adenocarcinoma. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are Human Early Embryo Development and Oct4 in Mammalian ESC Pluripotency. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and digestive/alimentary.

Wikipedia:63 Sacrococcygeal teratoma (SCT) is a teratoma (a kind of tumor) located at the base of the coccyx... more...

Aliases & Classifications for Sacrococcygeal Teratoma

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

sacrococcygeal teratoma 42 60


Related Diseases for Sacrococcygeal Teratoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to sacrococcygeal teratoma

Clinical Features for Sacrococcygeal Teratoma

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Drugs & Therapeutics for Sacrococcygeal Teratoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sacrococcygeal Teratoma

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Anatomical Context for Sacrococcygeal Teratoma

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Animal Models for Sacrococcygeal Teratoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sacrococcygeal Teratoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.4CGA, AFP, PCNA, GDNF, RET
2MP:00053818.3POU5F1, MNX1, GDNF, RET, GFAP
3MP:00053868.0JUN, AFP, POU5F1, MNX1, GDNF, RET
4MP:00036317.7JUN, CGA, POU5F1, MNX1, GDNF, RET
5MP:00053787.6GFAP, RET, GDNF, PCNA, MNX1, CGA
6MP:00053797.6RET, JUN, CGA, AFP, POU5F1, MNX1
7MP:00053847.3JUN, POU5F1, MNX1, PCNA, GDNF, RET
8MP:00107687.0JUN, AFP, POU5F1, MNX1, PCNA, GDNF

Publications for Sacrococcygeal Teratoma

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Genetic Variations for Sacrococcygeal Teratoma

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Expression for genes affiliated with Sacrococcygeal Teratoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sacrococcygeal Teratoma

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Pathways for genes affiliated with Sacrococcygeal Teratoma

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51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Sacrococcygeal Teratoma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GFAP
2butyrate4410.5GFAP
3tachyplesin i4410.0PCNA, AFP
4ganciclovir44 1110.9AFP, RET
5eosin449.9GFAP, PCNA
6forskolin44 49 1111.8GDNF, GFAP
7oestriol449.8CGA, CGB7, AFP
88-bromo-cyclic amp449.8GFAP, CGA
9dbc-amp449.7CGA, GFAP, GDNF
10vinblastine44 49 1111.7CGA, AFP, JUN
11etoposide44 49 59 1112.7JUN, CGB7, AFP
12dopamine44 28 11 2412.7PCNA, GDNF, GFAP
13bleomycin44 1110.6CGA, CGB7, AFP
14mifepristone44 59 28 1112.6AFP, CGA, JUN
15silver449.6AFP, GFAP, PCNA
16polyethylene glycol449.6PCNA, AFP, GFAP
17glutamate449.5GFAP, GDNF, CGA
18kainate44 2810.5JUN, GFAP, GDNF
19alpha-amanitin449.4GFAP, JUN
20paclitaxel44 49 1111.3GFAP, AFP, MUC16
21actinomycin d449.3CGA, AFP, GDNF, JUN
22carboplatin44 49 1111.3AFP, MUC16, CGA
23cytarabine44 49 1111.3GFAP, JUN, PCNA
24thyroxine44 2410.2CGB7, AFP, PCNA, CGA
25b 723449.2AFP, MUC16, PCNA
26methotrexate44 49 1111.2CGB7, CGA, PCNA, AFP
27agar449.2RET, GFAP, AFP, JUN
28hematoxylin449.1GFAP, MUC16, PCNA
29pd 98,059449.0GDNF, RET, GFAP, JUN
30cyclophosphamide44 49 1110.9PCNA, CGA, AFP, MUC16
31cyclic amp44 249.8CGA, JUN, GFAP, RET, GDNF
32genistein44 28 59 2 11 2413.7PCNA, JUN, GFAP, GDNF, RET
33oligonucleotide448.6PCNA, RET, GDNF, AFP, JUN
34iron44 249.6GDNF, GFAP, MUC16, AFP
35aspartate448.4PCNA, RET, AFP, CGA, GFAP, GDNF
36creatinine448.2GFAP, PCNA, GDNF, MUC16, AFP, CGA
37cysteine448.2JUN, CGB7, PCNA, GDNF, GFAP, RET
38dexamethasone44 49 28 1111.2AFP, PCNA, JUN, GDNF, GFAP, MUC16
39alanine448.2AFP, GFAP, PCNA, GDNF, MNX1, CGA
40threonine448.2GFAP, AFP, JUN, RET, MUC16
41h2o2448.1GDNF, MUC16, PCNA, AFP, CGA, JUN
42estradiol44 11 2410.1PCNA, GFAP, AFP, CGB7, CGA, MUC16
43lactate448.1CGB7, CGA, MUC16, AFP, GFAP, PCNA
44cisplatin44 49 59 1111.1AFP, CGB7, MUC16, PCNA, CGA, GFAP
45progesterone44 59 28 11 2412.1CGA, PCNA, GFAP, AFP, MUC16, CGB7
46paraffin447.9PCNA, RET, AFP, GFAP, MUC16, CGA
47serine447.7AFP, JUN, MUC16, RET, GDNF, GFAP
48testosterone44 59 11 2410.5AFP, GFAP, CGB7, CGA, RET, PCNA
49retinoic acid44 248.4GDNF, JUN, CGB7, AFP, POU5F1, MNX1
50vegf446.9GFAP, GDNF, RET, PCNA, MUC16, POU5F1

GO Terms for genes affiliated with Sacrococcygeal Teratoma

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16Gene Ontology
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Biological processes related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:0017149.7NANOG, POU5F1
2SMAD protein signal transductionGO:0603959.7AFP, JUN
3gonad developmentGO:0084069.6NANOG, CGA
4enteric nervous system developmentGO:0484849.2RET, GDNF
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.6JUN, CGA, POU5F1, GDNF, NANOG

Products for genes affiliated with Sacrococcygeal Teratoma

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Sources for Sacrococcygeal Teratoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet