MCID: SCR024
MIFTS: 40

Sacrococcygeal Teratoma malady

Rare diseases category

Aliases & Classifications for Sacrococcygeal Teratoma

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Sacrococcygeal Teratoma, Aliases & Descriptions:

Name: Sacrococcygeal Teratoma 30 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Sacrococcygeal Teratoma

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NIH Rare Diseases:41 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  it occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  though it is usually benign, there is a possibility that the teratoma could become malignant.  as such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  if not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  studies have found that sacrococcygeal teratomas recur in up to 22% of cases. last updated: 10/18/2013

MalaCards based summary: Sacrococcygeal Teratoma is related to teratoma and endodermal sinus tumor. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are G protein signaling H RAS regulation pathway and Oct4 in Mammalian ESC Pluripotency. The compounds tachyplesin i and oestriol have been mentioned in the context of this disorder. Affiliated tissues include heart, pituitary and eye, and related mouse phenotypes are digestive/alimentary and normal.

Wikipedia:63 Sacrococcygeal teratoma (SCT) is a type of tumor known as a teratoma that develops at the base of the... more...

Related Diseases for Sacrococcygeal Teratoma

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Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.6GFAP, MNX1, POU5F1, NANOG, CGA, CGB7
2endodermal sinus tumor30.7MUC16, AFP
3down syndrome30.6CGB7, CGA, AFP
4adenocarcinoma29.9MUC16, PCNA, CGB7, AFP
5omphalocele10.5AFP
6oligohydramnios10.5AFP
7central hypoventilation syndrome, congenital10.5GDNF
8leydig cell tumor10.4CGA
9hydrops fetalis10.4
10testicular teratoma10.4CGA, AFP
11ovarian mixed germ cell neoplasm10.4AFP, CGA
12edwards syndrome10.4AFP, CGA
13ectopic pregnancy10.4CGA, CGB7
14anencephaly10.4AFP, CGA
15germ cell cancer10.4CGA, AFP
16neuroblastoma10.3
17urethritis10.3
18vaginitis10.3
19ring chromosome 2110.3
20schinzel giedion syndrome10.3
21struma ovarii10.3MUC16
22pineoblastoma10.3POU5F1, GFAP
23trophoblastic neoplasm10.3PCNA, CGA
24ovarian serous cystadenocarcinoma10.3MUC16
25gestational trophoblastic tumor10.3CGA, PCNA
26renal dysplasia10.3RET, GDNF
27neural tube defects10.3CGB7, CGA, AFP
28neuroma10.2RET, GDNF
29multiple endocrine neoplasia iia10.2GDNF, RET
30intestinal obstruction10.2RET, GDNF
31renal hypodysplasia/aplasia 110.2GDNF, RET
32embryonal cancer10.2NANOG, POU5F1, AFP
33multiple endocrine neoplasia10.2RET, GDNF
34hypothyroidism10.2RET, CGA
35germinoma10.2CGA, POU5F1, AFP
36dysgerminoma10.2POU5F1, CGA, AFP
37preeclampsia/eclampsia 110.2AFP, CGB7, CGA
38hirschsprung disease 110.2GDNF, RET
39multiple system atrophy10.2GDNF, GFAP
40ganglioneuroma10.2GFAP, RET
41testicular cancer10.2CGA, AFP
42pleomorphic adenoma10.2GFAP, PCNA
43gestational trophoblastic neoplasm10.2CGB7, CGA, PCNA
44sotos syndrome 110.2
45currarino syndrome10.2
46klippel-trenaunay-weber syndrome10.2
47wilms tumor10.2
48congestive heart failure10.2
49hemangioma10.2
50hemolytic anemia10.2

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to sacrococcygeal teratoma

Symptoms for Sacrococcygeal Teratoma

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Drugs & Therapeutics for Sacrococcygeal Teratoma

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Drug clinical trials:

Search ClinicalTrials for Sacrococcygeal Teratoma

Search NIH Clinical Center for Sacrococcygeal Teratoma

Genetic Tests for Sacrococcygeal Teratoma

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Anatomical Context for Sacrococcygeal Teratoma

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MalaCards organs/tissues related to Sacrococcygeal Teratoma:

31
Heart, Pituitary, Eye, Bone, Liver, Lung, Placenta

Animal Models for Sacrococcygeal Teratoma or affiliated genes

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MGI Mouse Phenotypes related to Sacrococcygeal Teratoma:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8GDNF, GFAP, MNX1, POU5F1, RET
2MP:00028738.6RET, JUN, POU5F1, MNX1, GFAP
3MP:00053898.4GDNF, AFP, POU5F1, RET, PCNA, CGA
4MP:00053868.2GDNF, GFAP, AFP, MNX1, POU5F1, JUN
5MP:00036318.1GDNF, GFAP, MNX1, POU5F1, JUN, RET
6MP:00053978.1GDNF, MNX1, POU5F1, JUN, RET, PCNA
7MP:00053787.9GDNF, GFAP, MNX1, JUN, RET, PCNA
8MP:00053847.9GDNF, GFAP, MNX1, POU5F1, JUN, NANOG
9MP:00053877.8GDNF, GFAP, MNX1, JUN, RET, PCNA
10MP:00053797.8CGA, GDNF, AFP, MNX1, POU5F1, JUN
11MP:00107687.1GDNF, GFAP, AFP, MNX1, POU5F1, JUN

Publications for Sacrococcygeal Teratoma

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Articles related to Sacrococcygeal Teratoma:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Sacrococcygeal teratoma with ectopic immature renal tissue. (25673616)
2015
2
Management of preterm giant sacrococcygeal teratoma (GSCT) with an excellent outcome. (25480837)
2014
3
Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature. (24488859)
2014
4
The long-term psychosocial outcomes following excision of sacrococcygeal teratoma: a national study. (24277662)
2013
5
Two cases of prenatally diagnosed sacrococcygeal teratoma type I with different clinical features. (23751044)
2013
6
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. (24057924)
2013
7
Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: a 25-year experience at a single institution. (23845611)
2013
8
Large sacrococcygeal teratoma hindering vaginal delivery attempted at home. (22866184)
2012
9
Echocardiographic risk stratification of fetuses with sacrococcygeal teratoma and twin-reversed arterial perfusion. (22086180)
2011
10
Partial trisomy 3q in a child with sacrococcygeal teratoma and Cornelia de Lange syndrome phenotype. (21848013)
2011
11
Foetal sacrococcygeal teratoma: extremes in clinical presentation. (21731981)
2011
12
Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre. (19184053)
2009
13
Sacrococcygeal teratoma in an adult female Nigerian. (19253526)
2008
14
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
15
Prenatal diagnosis of type I sacrococcygeal teratoma and its management. (18581776)
2008
16
Corticotrophin-dependent Cushing syndrome due to Sacrococcygeal Teratoma detected by [18F]fluorodeoxyglucose positron emission tomography. (18772458)
2008
17
Mature sacrococcygeal teratoma: case report. (19357734)
2008
18
Mirror syndrome associated with sacrococcygeal teratoma: a case report. (17465292)
2007
19
Neurogenic bladder dysfunction after sacrococcygeal teratoma resection. (16406929)
2006
20
Factors associated with recurrence and metastasis in sacrococcygeal teratoma. (17058315)
2006
21
Spontaneous rupture of fetal sacrococcygeal teratoma. (16912491)
2006
22
Management of sacrococcygeal teratoma of the fetus. (15321048)
2004
23
Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 cases. (14564114)
2003
24
Prenatal diagnosis of sacrococcygeal teratoma: a review of cases between 1993 and 2000. (12013082)
2002
25
Sacrococcygeal teratoma. (12415361)
2002
26
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
27
Successful intrauterine shunting of a sacrococcygeal teratoma (SCT) causing fetal bladder obstruction. (11746122)
2001
28
Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. (11051157)
2000
29
In utero fetal surgery for sacrococcygeal teratoma. (10848120)
2000
30
DNA ploidy analysis and cell proliferation in congenital sacrococcygeal teratomas. (10951360)
2000
31
Sacrococcygeal teratoma associated with a normal alpha-fetoprotein concentration. (9286870)
1997
32
Sacrococcygeal teratoma in Zaria, Nigeria: report of 47 cases. (8687206)
1995
33
Neonatal sacrococcygeal teratoma: prolonged survival after malignant relapse. (7703049)
1995
34
Lower urinary tract dysfunction in children with benign sacrococcygeal teratoma. (8254808)
1994
35
The association of sacrococcygeal teratoma with high anorectal and genital malformations. (8117204)
1994
36
Anorectal function in adults operated for a benign sacrococcygeal teratoma. (8308684)
1993
37
Urological aspects of sacrococcygeal teratoma in children. (8345616)
1993
38
Sacrococcygeal teratoma and venous shunting through a tumor: biological evidence. (1734786)
1992
39
Sacrococcygeal teratoma in Sweden: a 10-year national retrospective study. (1282543)
1992
40
Neonatal sacrococcygeal teratoma: multiimaging modality assessment. (2193140)
1990
41
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
42
Sacrococcygeal teratoma: computed tomography evaluation. (3581859)
1987
43
Vaginal delivery impeded by a large fetal sacrococcygeal teratoma: anesthetic considerations. (3688507)
1987
44
Giant sacrococcygeal teratoma in an African child. (3829022)
1986
45
Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey-1973. (4843993)
1974
46
Sacrococcygeal teratoma. (14405262)
1959
47
Sacrococcygeal teratoma. (13533715)
1958
48
Sacrococcygeal teratoma including case report. (13040721)
1953
49
A case of congenital sacrococcygeal teratoma. (14886605)
1951
50
Sacrococcygeal teratoma with urinary retention. (15403717)
1950

Variations for Sacrococcygeal Teratoma

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Expression for genes affiliated with Sacrococcygeal Teratoma

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Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for genes affiliated with Sacrococcygeal Teratoma

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Pathways related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7RET, GDNF
29.5POU5F1, NANOG
39.5NANOG, POU5F1
49.5NANOG, POU5F1
59.4CGA, AFP, JUN
6
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.3RET, JUN, GDNF
79.3GDNF, JUN, RET
89.2AFP, POU5F1, NANOG
99.2AFP, JUN, PCNA
10
Show member pathways
9.2POU5F1, NANOG, CGA
11
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.1JUN, POU5F1, NANOG
128.6NANOG, RET, JUN, POU5F1

Compounds for genes affiliated with Sacrococcygeal Teratoma

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Compounds related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1tachyplesin i4310.0AFP, PCNA
2oestriol439.8AFP, CGA, CGB7
3dbc-amp439.8GDNF, GFAP, CGA
4eosin439.8PCNA, GFAP
5vinblastine43 49 1211.8AFP, JUN, CGA
6ganciclovir43 1210.7RET, AFP, GFAP
7bleomycin43 1210.6AFP, CGB7, CGA
8silver439.6PCNA, GFAP, AFP
9mifepristone43 28 59 1212.5CGA, JUN, AFP
10polyethylene glycol439.5GFAP, AFP, PCNA
11kainate43 2810.4GFAP, JUN, GDNF
12actinomycin d439.4CGA, JUN, AFP, GDNF
13agar439.3RET, JUN, GFAP, AFP
14carboplatin43 49 1211.3MUC16, CGA, AFP
15thyroxine43 2410.2CGB7, AFP, PCNA, CGA
16b 723439.2PCNA, AFP, MUC16
17pd 98,059439.2GDNF, JUN, RET, GFAP
18methotrexate49 43 1211.2PCNA, CGB7, AFP, CGA
19forskolin43 49 1211.2JUN, CGA, GFAP, GDNF
20cytarabine43 49 1211.1PCNA, JUN, GFAP
21hematoxylin439.1GFAP, PCNA, MUC16
22cyclic amp43 2410.0JUN, GFAP, GDNF, CGA, RET
23glutamate439.0PCNA, CGA, AFP, GFAP, GDNF
24cyclophosphamide43 49 1210.9MUC16, AFP, PCNA, CGA
25butyrate438.8RET, GFAP, AFP, JUN, PCNA
26oligonucleotide438.8JUN, RET, GDNF, AFP, PCNA
27etoposide43 49 59 1211.8JUN, PCNA, AFP, CGA, CGB7
28paclitaxel43 49 1210.8PCNA, MUC16, AFP, GFAP
29genistein43 28 59 2 24 1213.8GDNF, PCNA, GFAP, JUN, RET
30oxygen43 249.7POU5F1, JUN, GFAP, AFP, GDNF
31aspartate438.7AFP, PCNA, GDNF, RET, GFAP, CGA
32dopamine43 28 24 1211.6GDNF, POU5F1, GFAP, RET, PCNA, CGA
33threonine438.4RET, MUC16, JUN, AFP, GFAP
34alanine438.4GDNF, PCNA, GFAP, AFP, MNX1, RET
35iron43 249.4GDNF, GFAP, AFP, MUC16
36creatinine438.3AFP, GDNF, CGA, GFAP, PCNA, MUC16
37cysteine438.2PCNA, CGB7, JUN, GFAP, GDNF, RET
38paraffin438.2GFAP, AFP, MUC16, RET, PCNA, CGA
39h2o2438.2CGA, GDNF, MUC16, PCNA, AFP, JUN
40dexamethasone43 49 28 1211.1GFAP, MUC16, PCNA, GDNF, JUN, AFP
41estradiol43 24 1210.1CGB7, CGA, PCNA, MUC16, AFP, GFAP
42lactate438.1GFAP, AFP, PCNA, CGA, CGB7, MUC16
43cisplatin43 49 59 1211.1GFAP, AFP, PCNA, CGA, MUC16, CGB7
44progesterone43 28 59 24 1212.1GFAP, MUC16, PCNA, CGA, CGB7, AFP
45serine437.9GFAP, MUC16, JUN, AFP, GDNF, RET
46estrogen437.8PCNA, GFAP, AFP, JUN, GDNF, MUC16
47tyrosine437.7GDNF, GFAP, AFP, JUN, MUC16, RET
48testosterone43 59 24 1210.7CGA, PCNA, MUC16, CGB7, AFP, GFAP
49retinoic acid43 248.4AFP, MNX1, JUN, POU5F1, CGB7, PCNA
50vegf437.1CGA, GDNF, GFAP, AFP, POU5F1, JUN

GO Terms for genes affiliated with Sacrococcygeal Teratoma

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Biological processes related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:00603959.8AFP, JUN
2enteric nervous system developmentGO:00484849.7GDNF, RET
3endodermal cell fate specificationGO:00017149.7NANOG, POU5F1
4somatic stem cell maintenanceGO:00350199.5NANOG, POU5F1
5gonad developmentGO:00084069.5NANOG, CGA
6neural crest cell migrationGO:00017559.4RET, GDNF
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.5GDNF, POU5F1, JUN, NANOG, CGA

Products for genes affiliated with Sacrococcygeal Teratoma

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Sources for Sacrococcygeal Teratoma

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
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51QIAGEN
56SNOMED-CT via Orphanet
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61UMLS via Orphanet