Sacrococcygeal Teratoma malady

NIH Rare Diseases: A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  It occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  Though it is usually benign, there is a possibility that the teratoma could become malignant.  As such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  If not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  Studies have found that sacrococcygeal teratomas recur in up to 22% of cases.³⁰

MalaCards: Sacrococcygeal Teratoma is related to teratoma and polyembryoma. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are Oct4 in Mammalian ESC Pluripotency and Human Early Embryo Development. The compounds eosin and agar have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Wikipedia: Sacrococcygeal teratoma (SCT) is a teratoma (a kind of tumor) located at the base of the coccyx...⁴⁴ more...

sacrococcygeal teratoma 30 43

Diseases related to sacrococcygeal teratoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 131)

id	Related Disease	Score	Top Affiliating Genes
1	teratoma	28.0	AFP, CGA, NANOG, GDNF, JUN, MNX1
2	polyembryoma	13.3	AFP, CGA
3	ovarian mixed germ cell neoplasm	13.2	CGA, AFP
4	cutis marmorata telangiectatica congenita	13.2	AFP, CGA
5	ectopic pregnancy	13.2	CGA, CGB7
6	mature teratoma	13.2	CGA, AFP
7	urachal adenocarcinoma	13.1	PCNA, AFP
8	hydrocele	13.1	AFP, CGA
9	anencephaly	13.1	CGA, AFP
10	gestational trophoblastic neoplasm	13.1	CGA, AFP
11	endodermal sinus tumor	13.1	AFP, MUC16
12	trophoblastic neoplasm	13.0	CGA, PCNA
13	edwards syndrome	13.0	AFP, CGA
14	myoepithelial carcinoma	13.0	PCNA, GFAP
15	gestational trophoblastic tumor	13.0	PCNA, CGA
16	ovarian cyst	13.0	CGA, MUC16
17	nonseminomatous germ cell tumor	13.0	CGB7, AFP, CGA
18	epithelial-myoepithelial carcinoma	13.0	GFAP, PCNA
19	medullary sponge kidney	13.0	GDNF, RET
20	cerebellar medulloblastoma	13.0	GFAP, PCNA
21	neural tube defect	13.0	AFP, CGB7, CGA
22	anaplastic plasmacytoma	13.0	GFAP, PCNA
23	mesenchymal cell neoplasm	12.9	GFAP, PCNA
24	ovarian mucinous cystadenocarcinoma	12.9	MUC16, PCNA
25	dysgerminoma	12.9	CGA, AFP, POU5F1
26	congenital central hypoventilation syndrome	12.9	GDNF, RET
27	central hypoventilation syndrome	12.9	GDNF, RET
28	multiple endocrine neoplasia type 2a	12.9	RET, GDNF
29	pituitary carcinoma	12.8	GFAP, PCNA
30	pineoblastoma	12.8	CGA, POU5F1, GFAP
31	central neurocytoma	12.8	GFAP, PCNA
32	struma ovarii	12.8	MUC16, RET
33	myoepithelioma	12.8	GFAP, PCNA
34	fragile x-associated primary ovarian insufficiency	12.8	MUC16, CGA
35	ovarian sex cord tumors	12.8	AFP, MUC16
36	retinal ischemia	12.8	GFAP, PCNA
37	mucinous cystadenocarcinoma	12.8	MUC16, PCNA
38	sycp3-related pregnancy loss, susceptibility to	12.8	CGA, CGB7
39	germ cell cancer	12.7	AFP, CGA, PCNA
40	leydig cell tumor	12.7	AFP, MUC16, CGA
41	abrikosov's tumor	12.7	AFP, CGA, MUC16
42	germinoma	12.7	CGA, POU5F1, AFP, CGB7
43	intestinal obstruction	12.6	RET, GDNF
44	rectal cloacogenic carcinoma	12.6	CGB7, PCNA, MUC16
45	craniopharyngioma	12.6	GFAP, CGA, PCNA
46	spontaneous abortion	12.6	CGA, MUC16, AFP
47	neuroendocrine carcinoma	12.5	MUC16, AFP, PCNA
48	achalasia	12.5	RET, PCNA, GDNF
49	vaginitis	12.4	AFP, CGB7, MUC16, CGA
50	virilization	12.4	AFP, CGA, JUN

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to sacrococcygeal teratoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.5	RET, MNX1, AFP
2	behavior/neurological phenotype	MP:0005386	8.2	GFAP, MNX1, JUN, POU5F1, GDNF
3	mortality/aging	MP:0010768	7.9	RET, GDNF, AFP, POU5F1, GFAP, MNX1
4	reproductive system phenotype	MP:0005389	7.7	GDNF, AFP, CGA, PCNA, RET, POU5F1

Articles related to sacrococcygeal teratoma:

id	Title	Authors	Year	Affiliating Genes
1	Tumor markers AFP, CA 125, and CA 19-9 in the long-te rm follow-up of sacrococcygeal teratomas in infancy and childhood. (20361286)	Pauniaho S.L.... Heikinheimo M.	2010	MUC16
2	Isolation of three stem cell lines from human sacrococcygeal teratomas. (19142973)	Busch C.... Drews U.	2009	AFP
3	Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. (18439155)	Busch C.... Drews U.	2008	POU5F1, NANOG
4	Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. (14663834)	Le Caignec C.... Rival J.M.	2003	MNX1
5	DNA ploidy analysis and cell proliferation in congeni tal sacrococcygeal teratomas. (10951360)	Kruslin B.... Seiwerth S.	2000	PCNA
6	Congenital sacrococcygeal teratomas: effect of gestational age on size, morphologic pattern, ploidy, p53, and ret expression. (10742411)	Herrmann M.E.... Husain A.N.	2000	RET, GDNF
7	Oncoproteins and tumor suppressor proteins in congenital sacrococcygeal teratomas. (9050059)	Kruslin B.... PaveliA8 K.	1997	JUN
8	Maternal serum alpha-fetoprotein and epithelial tumour marker concentrations are not increased by fetal sacrococcygeal teratoma. (9021828)	Kirkinen P.... RyynAonen M.	1997	CGA, AFP, CGB7
9	Cell differentiation in sacrococcygeal teratomas. An immunohistochemical and follow-up study. (1696006)	Lahdenne P.... Miettinen M.	1990	GFAP

Genes related to sacrococcygeal teratoma according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	MNX1	motor neuron and pancreas homeobox 1	11.0	Publications
2	NANOG	Nanog homeobox	11.0	Publications
3	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
4	POU5F1	POU class 5 homeobox 1	11.0	Publications
5	AFP	alpha-fetoprotein	11.0	Publications
6	GDNF	glial cell derived neurotrophic factor	11.0	Publications
7	RET	ret proto-oncogene	11.0	Publications
8	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
9	GFAP	glial fibrillary acidic protein	11.0	Publications
10	MUC16	mucin 16, cell surface associated	11.0	Publications
11	PCNA	proliferating cell nuclear antigen	11.0	Publications
12	JUN	jun proto-oncogene	11.0	Publications

Pathways related to sacrococcygeal teratoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Oct4 in Mammalian ESC Pluripotency36	9.9	POU5F1, NANOG
2	Human Early Embryo Development36	9.8	POU5F1, NANOG
3	Development_Role of Activin A in cell differentiation and proliferation41	9.6	POU5F1, CGA, NANOG
4	Selected targets of Oct-3/410	9.6	POU5F1, NANOG, CGB7
5	Development Role of Activin A in cell differentiation and proliferation10	9.6	POU5F1, CGA, NANOG
6	Development GDNF family signaling10	9.3	RET, JUN, GDNF
7	Development_GDNF family signaling41	9.2	RET, JUN, GDNF
8	Wnt / Hedgehog / Notch3	9.2	NANOG, AFP, POU5F1

Compounds related to sacrococcygeal teratoma according to GeneDecks:

(show top 50)    (show all 62)

id	Compound	Score	Top Affiliating Genes
1	eosin32	10.3	GFAP
2	agar32	10.1	AFP, RET
3	threonine32	9.9	AFP, RET
4	oestriol32	9.8	AFP, CGB7, CGA
5	tachyplesin i32	9.7	PCNA, AFP
6	bleomycin32 9 9	11.7	CGA, CGB7, AFP
7	butyrate32	9.6	RET, JUN, AFP
8	ganciclovir32 9 9	11.6	GFAP, RET, AFP
9	vinblastine32 9 9	11.5	JUN, AFP, CGA
10	dbc-amp32	9.4	CGA, GFAP, GDNF
11	alpha-amanitin32	9.4	GFAP, JUN
12	h2o232	9.4	GDNF, CGA, MUC16
13	8-bromo-cyclic amp32	9.4	GFAP, CGA
14	mifepristone32 42 9 9	12.4	JUN, AFP, CGA
15	carboplatin32 34 9 9	12.4	CGA, MUC16, AFP
16	kainate32	9.3	GFAP, GDNF, JUN
17	glutamate32	9.2	PCNA, GFAP
18	reticulin32	9.1	PCNA, GFAP
19	cysteine32	9.1	GFAP, PCNA, GDNF
20	b 72332	9.1	PCNA, AFP, MUC16
21	silver32	9.1	AFP, GFAP, PCNA
22	polyethylene glycol32	9.1	AFP, PCNA, GFAP
23	actinomycin d32	9.0	GDNF, CGA, AFP, JUN
24	thyroxine32 18	9.9	CGB7, AFP, PCNA, CGA
25	methotrexate32 34 42 9 9	12.9	CGA, AFP, CGB7, PCNA
26	pd 98,05932	8.9	GFAP, GDNF, JUN, RET
27	cetrorelix32 9 9	10.9	CGA, PCNA
28	hematoxylin32	8.9	PCNA, MUC16, GFAP
29	cytarabine32 34 9 9	11.8	PCNA, JUN, GFAP
30	forskolin32 42 9 9	11.7	GDNF, CGA, GFAP, JUN
31	cyclic amp32 18	9.6	RET, CGA, JUN, GFAP, GDNF
32	paclitaxel32 34 9 9	11.5	GFAP, AFP, MUC16, PCNA
33	estradiol32 9 18 9	11.5	CGA, AFP, CGB7, GFAP, PCNA
34	etoposide32 42 9 9	11.4	AFP, CGB7, PCNA, CGA, JUN
35	aspartate32	8.3	GFAP, GDNF, RET, CGA, PCNA
36	oligonucleotide32	8.3	GDNF, PCNA, JUN, RET, AFP
37	genistein32 9 18 9	11.2	PCNA, RET, GFAP, JUN, GDNF
38	dopamine32 9 18 9	11.0	POU5F1, PCNA, GFAP, GDNF, CGA, RET
39	cisplatin32 34 9 9	10.8	CGB7, GFAP, CGA, PCNA, AFP, MUC16
40	lactate32	7.8	AFP, GFAP, CGB7, CGA, MUC16, PCNA
41	progesterone32 42 9 18 9	11.8	GFAP, CGB7, PCNA, MUC16, CGA, AFP
42	creatinine32	7.8	CGA, AFP, GFAP, GDNF, MUC16, PCNA
43	paraffin32	7.7	GFAP, AFP, PCNA, RET, CGA, MUC16
44	alanine32	7.7	RET, PCNA, CGA, MNX1, AFP, GDNF
45	dexamethasone32 42 34 9 9	11.7	MUC16, AFP, PCNA, JUN, GFAP, GDNF
46	serine32	7.6	CGA, GDNF, GFAP, JUN, RET, MUC16
47	testosterone32 9 18 9	10.4	PCNA, MUC16, CGA, CGB7, GFAP, AFP
48	estrogen32	7.2	GDNF, PCNA, MUC16, CGA, JUN, GFAP
49	retinoic acid32 42 18	9.0	CGB7, PCNA, RET, MNX1, GFAP, POU5F1
50	vegf32	6.5	CGA, MUC16, AFP, GDNF, POU5F1, GFAP

Biological processes related to sacrococcygeal teratoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endodermal cell fate specification	GO:001714	9.9	NANOG, POU5F1
2	neural crest cell migration	GO:001755	9.7	GDNF, RET
3	enteric nervous system development	GO:048484	9.6	RET, GDNF
4	SMAD protein signal transduction	GO:060395	9.3	JUN, AFP
5	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	GDNF, POU5F1, JUN, CGA, NANOG