MCID: SCR024
MIFTS: 47

Sacrococcygeal Teratoma malady

Rare diseases category
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Summaries for Sacrococcygeal Teratoma

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NIH Rare Diseases:42 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  it occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  though it is usually benign, there is a possibility that the teratoma could become malignant.  as such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  if not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  studies have found that sacrococcygeal teratomas recur in up to 22% of cases. last updated: 10/18/2013

MalaCards based summary: Sacrococcygeal Teratoma is related to teratoma and endodermal sinus tumor. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are G protein signaling H RAS regulation pathway and Human Early Embryo Development. The compounds tachyplesin i and oestriol have been mentioned in the context of this disorder. Affiliated tissues include heart, pituitary and eye, and related mouse phenotypes are digestive/alimentary and normal.

Wikipedia:65 Sacrococcygeal teratoma (SCT) is a teratoma (a kind of tumor) located at the base of the coccyx... more...

Aliases & Classifications for Sacrococcygeal Teratoma

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Sacrococcygeal Teratoma, Aliases & Descriptions:

Name: Sacrococcygeal Teratoma 30 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Sacrococcygeal Teratoma

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Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.6GFAP, MNX1, POU5F1, NANOG, CGA, CGB7
2endodermal sinus tumor30.7MUC16, AFP
3down syndrome30.6CGB7, CGA, AFP
4adenocarcinoma30.0MUC16, PCNA, CGB7, AFP
5omphalocele10.5AFP
6familial medullary thyroid carcinoma10.5GDNF
7oligohydramnios10.5AFP
8central hypoventilation syndrome10.5GDNF
9leydig cell tumor10.4CGA
10hydrops fetalis10.4
11schinzel giedion syndrome10.4
12male germ cell tumor, somatic10.4CGA, AFP
13ectopic pregnancy10.4CGA, CGB7
14edwards syndrome10.4AFP, CGA
15anencephaly10.4AFP, CGA
16germ cell cancer10.4CGA, AFP
17pregnancy loss10.3CGA, CGB7
18urethritis10.3
19neuroblastoma10.3
20vaginitis10.3
21ring chromosome 2110.3
22struma ovarii10.3MUC16
23pineoblastoma10.3POU5F1, GFAP
24trophoblastic neoplasm10.3PCNA, CGA
25ovarian serous cystadenocarcinoma10.3MUC16
26gestational trophoblastic tumor10.3CGA, PCNA
27renal dysplasia10.3RET, GDNF
28neural tube defects10.3CGB7, CGA, AFP
29neuroma10.3RET, GDNF
30multiple endocrine neoplasia type 2a10.2GDNF, RET
31intestinal obstruction10.2RET, GDNF
32renal agenesis10.2GDNF, RET
33embryonal cancer10.2NANOG, POU5F1, AFP
34multiple endocrine neoplasia10.2RET, GDNF
35hypothyroidism10.2RET, CGA
36germinoma10.2CGA, POU5F1, AFP
37pre-eclampsia10.2AFP, CGB7, CGA
38dysgerminoma10.2POU5F1, CGA, AFP
39hirschsprung's disease10.2GDNF, RET
40multiple system atrophy10.2GDNF, GFAP
41ganglioneuroma10.2GFAP, RET
42testicular cancer10.2CGA, AFP
43pleomorphic adenoma10.2GFAP, PCNA
44gestational trophoblastic neoplasm10.2CGB7, CGA, PCNA
45congestive heart failure10.2
46hemangioma10.2
47hemolytic anemia10.2
48spina bifida10.2
49wilms tumor10.2
50sotos syndrome10.2

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to sacrococcygeal teratoma

Symptoms for Sacrococcygeal Teratoma

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Drugs & Therapeutics for Sacrococcygeal Teratoma

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Drug clinical trials:

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Genetic Tests for Sacrococcygeal Teratoma

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Anatomical Context for Sacrococcygeal Teratoma

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MalaCards organs/tissues related to Sacrococcygeal Teratoma:

32
Heart, Pituitary, Eye, Bone, Liver, Lung, Placenta

Animal Models for Sacrococcygeal Teratoma or affiliated genes

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MGI Mouse Phenotypes related to Sacrococcygeal Teratoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8GDNF, GFAP, MNX1, POU5F1, RET
2MP:00028738.6RET, JUN, POU5F1, MNX1, GFAP
3MP:00053898.4GDNF, AFP, POU5F1, RET, PCNA, CGA
4MP:00053868.2GDNF, GFAP, AFP, MNX1, POU5F1, JUN
5MP:00036318.1GDNF, GFAP, MNX1, POU5F1, JUN, RET
6MP:00053978.1GDNF, MNX1, POU5F1, JUN, RET, PCNA
7MP:00053787.9GDNF, GFAP, MNX1, JUN, RET, PCNA
8MP:00053847.9GDNF, GFAP, MNX1, POU5F1, JUN, NANOG
9MP:00053877.8GDNF, GFAP, MNX1, JUN, RET, PCNA
10MP:00053797.8CGA, GDNF, AFP, MNX1, POU5F1, JUN
11MP:00107687.1GDNF, GFAP, AFP, MNX1, POU5F1, JUN

Publications for Sacrococcygeal Teratoma

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Articles related to Sacrococcygeal Teratoma:

(show top 50)    (show all 386)
idTitleAuthorsYear
1
Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature. (24488859)
2014
2
The long-term psychosocial outcomes following excision of sacrococcygeal teratoma: a national study. (24277662)
2013
3
Two cases of prenatally diagnosed sacrococcygeal teratoma type I with different clinical features. (23751044)
2013
4
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. (24057924)
2013
5
Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: a 25-year experience at a single institution. (23845611)
2013
6
Large sacrococcygeal teratoma hindering vaginal delivery attempted at home. (22866184)
2012
7
Echocardiographic risk stratification of fetuses with sacrococcygeal teratoma and twin-reversed arterial perfusion. (22086180)
2011
8
Partial trisomy 3q in a child with sacrococcygeal teratoma and Cornelia de Lange syndrome phenotype. (21848013)
2011
9
Foetal sacrococcygeal teratoma: extremes in clinical presentation. (21731981)
2011
10
Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre. (19184053)
2009
11
Sacrococcygeal teratoma in an adult female Nigerian. (19253526)
2008
12
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
13
Prenatal diagnosis of type I sacrococcygeal teratoma and its management. (18581776)
2008
14
Corticotrophin-dependent Cushing syndrome due to Sacrococcygeal Teratoma detected by [18F]fluorodeoxyglucose positron emission tomography. (18772458)
2008
15
Mature sacrococcygeal teratoma: case report. (19357734)
2008
16
Mirror syndrome associated with sacrococcygeal teratoma: a case report. (17465292)
2007
17
Neurogenic bladder dysfunction after sacrococcygeal teratoma resection. (16406929)
2006
18
Factors associated with recurrence and metastasis in sacrococcygeal teratoma. (17058315)
2006
19
Spontaneous rupture of fetal sacrococcygeal teratoma. (16912491)
2006
20
Management of sacrococcygeal teratoma of the fetus. (15321048)
2004
21
Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 cases. (14564114)
2003
22
Prenatal diagnosis of sacrococcygeal teratoma: a review of cases between 1993 and 2000. (12013082)
2002
23
Sacrococcygeal teratoma. (12415361)
2002
24
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
25
Successful intrauterine shunting of a sacrococcygeal teratoma (SCT) causing fetal bladder obstruction. (11746122)
2001
26
Successful fetal sacrococcygeal teratoma resection in a hydropic fetus. (11051157)
2000
27
In utero fetal surgery for sacrococcygeal teratoma. (10848120)
2000
28
DNA ploidy analysis and cell proliferation in congenital sacrococcygeal teratomas. (10951360)
2000
29
Sacrococcygeal teratoma associated with a normal alpha-fetoprotein concentration. (9286870)
1997
30
Sacrococcygeal teratoma in Zaria, Nigeria: report of 47 cases. (8687206)
1995
31
Neonatal sacrococcygeal teratoma: prolonged survival after malignant relapse. (7703049)
1995
32
Lower urinary tract dysfunction in children with benign sacrococcygeal teratoma. (8254808)
1994
33
The association of sacrococcygeal teratoma with high anorectal and genital malformations. (8117204)
1994
34
Sacrococcygeal teratoma in children: a diagnostic challenge. (8291972)
1994
35
Anorectal function in adults operated for a benign sacrococcygeal teratoma. (8308684)
1993
36
Urological aspects of sacrococcygeal teratoma in children. (8345616)
1993
37
Sacrococcygeal teratoma and venous shunting through a tumor: biological evidence. (1734786)
1992
38
Sacrococcygeal teratoma in Sweden: a 10-year national retrospective study. (1282543)
1992
39
The management of prenatally diagnosed sacrococcygeal teratoma. (17587029)
1992
40
Neonatal sacrococcygeal teratoma: multiimaging modality assessment. (2193140)
1990
41
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
42
Sacrococcygeal teratoma: computed tomography evaluation. (3581859)
1987
43
Vaginal delivery impeded by a large fetal sacrococcygeal teratoma: anesthetic considerations. (3688507)
1987
44
Giant sacrococcygeal teratoma in an African child. (3829022)
1986
45
Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey-1973. (4843993)
1974
46
Sacrococcygeal teratoma. (14405262)
1959
47
Sacrococcygeal teratoma. (13533715)
1958
48
Sacrococcygeal teratoma including case report. (13040721)
1953
49
A case of congenital sacrococcygeal teratoma. (14886605)
1951
50
Sacrococcygeal teratoma with urinary retention. (15403717)
1950

Variations for Sacrococcygeal Teratoma

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Expression for genes affiliated with Sacrococcygeal Teratoma

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Expression patterns in normal tissues for genes affiliated with Sacrococcygeal Teratoma

Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for genes affiliated with Sacrococcygeal Teratoma

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Pathways related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7RET, GDNF
29.5POU5F1, NANOG
39.5NANOG, POU5F1
49.5NANOG, POU5F1
59.4CGA, JUN, AFP
6
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3RET, JUN, GDNF
79.3RET, JUN, GDNF
89.2NANOG, POU5F1, AFP
99.2AFP, JUN, PCNA
10
Show member pathways
9.2CGA, NANOG, POU5F1
11
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.1POU5F1, JUN, NANOG
129.0POU5F1, NANOG, CGB7
138.6RET, NANOG, JUN, POU5F1

Compounds for genes affiliated with Sacrococcygeal Teratoma

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Compounds related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1tachyplesin i4410.0AFP, PCNA
2oestriol449.8AFP, CGA, CGB7
3dbc-amp449.8GDNF, GFAP, CGA
4eosin449.8PCNA, GFAP
5vinblastine44 50 1111.8AFP, JUN, CGA
6ganciclovir44 1110.7RET, AFP, GFAP
7bleomycin44 1110.6AFP, CGB7, CGA
8silver449.6PCNA, GFAP, AFP
9mifepristone44 28 61 1112.5CGA, JUN, AFP
10polyethylene glycol449.5GFAP, AFP, PCNA
11kainate44 2810.4GFAP, JUN, GDNF
12actinomycin d449.4CGA, JUN, AFP, GDNF
13agar449.3RET, JUN, GFAP, AFP
14carboplatin44 50 1111.3MUC16, CGA, AFP
15thyroxine44 2410.2CGB7, AFP, PCNA, CGA
16b 723449.2PCNA, AFP, MUC16
17pd 98,059449.2GDNF, JUN, RET, GFAP
18methotrexate50 44 1111.2PCNA, CGB7, AFP, CGA
19forskolin44 50 1111.2JUN, CGA, GFAP, GDNF
20cytarabine44 50 1111.1PCNA, JUN, GFAP
21hematoxylin449.1GFAP, PCNA, MUC16
22cyclic amp44 2410.0JUN, GFAP, GDNF, CGA, RET
23glutamate449.0PCNA, CGA, AFP, GFAP, GDNF
24cyclophosphamide44 50 1110.9MUC16, AFP, PCNA, CGA
25butyrate448.8RET, GFAP, AFP, JUN, PCNA
26oligonucleotide448.8JUN, RET, GDNF, AFP, PCNA
27etoposide44 50 61 1111.8JUN, PCNA, AFP, CGA, CGB7
28paclitaxel44 50 1110.8PCNA, MUC16, AFP, GFAP
29genistein44 28 61 2 24 1113.8GDNF, PCNA, GFAP, JUN, RET
30oxygen44 249.7POU5F1, JUN, GFAP, AFP, GDNF
31aspartate448.7AFP, PCNA, GDNF, RET, GFAP, CGA
32dopamine44 28 24 1111.6GDNF, POU5F1, GFAP, RET, PCNA, CGA
33threonine448.4RET, MUC16, JUN, AFP, GFAP
34alanine448.4GDNF, PCNA, GFAP, AFP, MNX1, RET
35iron44 249.4GDNF, GFAP, AFP, MUC16
36creatinine448.3AFP, GDNF, CGA, GFAP, PCNA, MUC16
37cysteine448.2PCNA, CGB7, JUN, GFAP, GDNF, RET
38paraffin448.2GFAP, AFP, MUC16, RET, PCNA, CGA
39h2o2448.2CGA, GDNF, MUC16, PCNA, AFP, JUN
40dexamethasone44 50 28 1111.1GFAP, MUC16, PCNA, GDNF, JUN, AFP
41estradiol44 24 1110.1CGB7, CGA, PCNA, MUC16, AFP, GFAP
42lactate448.1GFAP, AFP, PCNA, CGA, CGB7, MUC16
43cisplatin44 50 61 1111.1GFAP, AFP, PCNA, CGA, MUC16, CGB7
44progesterone44 28 61 24 1112.1GFAP, MUC16, PCNA, CGA, CGB7, AFP
45serine447.9GFAP, MUC16, JUN, AFP, GDNF, RET
46estrogen447.8PCNA, GFAP, AFP, JUN, GDNF, MUC16
47tyrosine447.7GDNF, GFAP, AFP, JUN, MUC16, RET
48testosterone44 61 24 1110.7CGA, PCNA, MUC16, CGB7, AFP, GFAP
49retinoic acid44 248.4AFP, MNX1, JUN, POU5F1, CGB7, PCNA
50vegf447.1CGA, GDNF, GFAP, AFP, POU5F1, JUN

GO Terms for genes affiliated with Sacrococcygeal Teratoma

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Biological processes related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:0603959.8AFP, JUN
2enteric nervous system developmentGO:0484849.7RET, GDNF
3endodermal cell fate specificationGO:0017149.7NANOG, POU5F1
4somatic stem cell maintenanceGO:0350199.5NANOG, POU5F1
5gonad developmentGO:0084069.5CGA, NANOG
6neural crest cell migrationGO:0017559.4RET, GDNF
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5CGA, NANOG, JUN, POU5F1, GDNF

Products for genes affiliated with Sacrococcygeal Teratoma

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Sources for Sacrococcygeal Teratoma

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
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40NDF-RT
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