MCID: SCR024
MIFTS: 32

Sacrococcygeal Teratoma

Categories: Rare diseases

Aliases & Classifications for Sacrococcygeal Teratoma

MalaCards integrated aliases for Sacrococcygeal Teratoma:

Name: Sacrococcygeal Teratoma 37 49 55 28 69

Classifications:



External Ids:

Orphanet 55 ORPHA494421
UMLS 69 C0559459

Summaries for Sacrococcygeal Teratoma

NIH Rare Diseases : 49 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  It occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  Though it is usually benign, there is a possibility that the teratoma could become malignant.  As such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  If not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  Studies have found that sacrococcygeal teratomas recur in up to 22% of cases. Last updated: 10/18/2013

MalaCards based summary : Sacrococcygeal Teratoma is related to teratoma and down syndrome. An important gene associated with Sacrococcygeal Teratoma is MNX1 (Motor Neuron And Pancreas Homeobox 1), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. Affiliated tissues include Primitive Streak, heart and pituitary.

Wikipedia : 72 Sacrococcygeal teratoma (SCT) is a type of tumor known as a teratoma that develops at the base of the... more...

Related Diseases for Sacrococcygeal Teratoma

Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.7 AFP CGA MNX1
2 down syndrome 29.0 AFP CGB7
3 neural tube defects 28.7 AFP MNX1
4 alpha-fetoprotein deficiency 10.1
5 hydrops fetalis, nonimmune, and/or atrial septal defect 10.0
6 vaginitis 10.0
7 hydrops fetalis 10.0
8 neuroblastoma 10.0
9 wilms tumor 6 10.0
10 cardiac arrest 10.0
11 cornelia de lange syndrome 10.0
12 urethritis 10.0
13 endodermal sinus tumor 10.0
14 adenocarcinoma 10.0
15 fibrosarcoma 10.0
16 ring chromosome 21 10.0
17 schinzel giedion syndrome 10.0
18 nonseminomatous germ cell tumor 9.8 AFP CGB7
19 prune belly syndrome 9.8
20 sotos syndrome 1 9.8
21 diaphragmatic hernia, congenital 9.8
22 klippel-trenaunay-weber syndrome 9.8
23 currarino syndrome 9.8
24 pelvic organ prolapse 9.8
25 proteus syndrome 9.8
26 renal hypodysplasia/aplasia 1 9.8
27 vater/vacterl association 9.8
28 anemia, autoimmune hemolytic 9.8
29 chordoma 9.8
30 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
31 gastroschisis 9.8
32 aicardi syndrome 9.8
33 aging 9.8
34 wilms tumor 5 9.8
35 lipomyelomeningocele 9.8
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
37 episodic pain syndrome, familial, 1 9.8
38 congestive heart failure 9.8
39 hemangioma 9.8
40 hemolytic anemia 9.8
41 hydrocephalus 9.8
42 scoliosis 9.8
43 thrombosis 9.8
44 meningocele 9.8
45 hydronephrosis 9.8
46 cauda equina syndrome 9.8
47 conn's syndrome 9.8
48 neurogenic bladder 9.8
49 vacterl association 9.8
50 neuroendocrine tumor 9.8

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to Sacrococcygeal Teratoma

Symptoms & Phenotypes for Sacrococcygeal Teratoma

Drugs & Therapeutics for Sacrococcygeal Teratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Characterization of At-risk Population for Pre-sacral Tumor in CURRARINO Syndrome Completed NCT00780117

Search NIH Clinical Center for Sacrococcygeal Teratoma

Genetic Tests for Sacrococcygeal Teratoma

Genetic tests related to Sacrococcygeal Teratoma:

# Genetic test Affiliating Genes
1 Sacrococcygeal Teratoma 28

Anatomical Context for Sacrococcygeal Teratoma

MalaCards organs/tissues related to Sacrococcygeal Teratoma:

38
Heart, Pituitary, Uterus, Placenta, Adrenal Gland, Liver, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Sacrococcygeal Teratoma:
# Tissue Anatomical CompartmentCell Relevance
1 Primitive Streak Primitive Streak Affected by disease

Publications for Sacrococcygeal Teratoma

Articles related to Sacrococcygeal Teratoma:

(show top 50) (show all 447)
# Title Authors Year
1
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma. ( 29420371 )
2018
2
Antenatal Prediction of Neonatal Survival in Sacrococcygeal Teratoma. ( 29399854 )
2018
3
Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient. ( 29138922 )
2018
4
Surgical treatment of a type IV cystic sacrococcygeal teratoma with intraspinal extension utilizing a posterior-anterior-posterior approach: a case report. ( 29368306 )
2018
5
Early Delivery of Sacrococcygeal Teratoma with Intraspinal Extension. ( 28463844 )
2017
6
Risk factors for perioperative mortality and transfusion in sacrococcygeal teratoma resections. ( 28321971 )
2017
7
Mucinous tumor arising in a giant sacrococcygeal teratoma: A rare case report. ( 29381973 )
2017
8
Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma. ( 29152267 )
2017
9
Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. ( 28894920 )
2017
10
Giant sacrococcygeal teratoma: Management concerns with reporting of a rare occurrence of venous air embolism. ( 28217075 )
2017
11
Fetus in Fetu in Lieu of a Sacrococcygeal Teratoma: A Case Illuminating the Utility of Serial Prenatal Sonographic Examinations in Diagnosis. ( 28026891 )
2017
12
Unilateral renal agenesis with subseptate uterus and sacrococcygeal teratoma: A unique triad. ( 29089677 )
2017
13
Analysis of Recurrent Sacrococcygeal Teratoma in Children: Clinical Features, Relapse Risks, and Anorectal Functional Sequelae. ( 28042962 )
2017
14
Prune Belly Syndrome with Sacrococcygeal Teratoma. ( 28593491 )
2017
15
Adult sacrococcygeal teratoma with coccygectomy: A case report with a review of the literature. ( 29184711 )
2017
16
Sacrococcygeal teratoma presenting with vaginal discharge and polyp in an infant. ( 29269272 )
2017
17
Pediatric Intraocular Immature Teratoma Associated With Sacrococcygeal Teratoma. ( 28521629 )
2017
18
Successful Postnatal Management of Ruptured Giant Sacrococcygeal Teratoma. ( 28770134 )
2017
19
Sacrococcygeal Teratoma in a Seven-Day-Old Child with Pulmonary Differentiation. ( 28969230 )
2017
20
Use of intraoperative lateral pelvic X-ray to localize and ensure coccyx removal during sacrococcygeal teratoma resection. ( 27858188 )
2016
21
Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma: A case report and literature review. ( 27787388 )
2016
22
Sacrococcygeal Teratoma: Mistreated With Repeated Aspirations. ( 27398327 )
2016
23
Prenatal diagnosis of tethered spinal cord associated with sacrococcygeal teratoma. ( 26892808 )
2016
24
Acardiac twin pregnancies part II: Fetal risk of chorangioma and sacrococcygeal teratoma predicted by pump/acardiac umbilical vein diameters. ( 27273226 )
2016
25
Type IV Sacrococcygeal Teratoma Displacing the Urinary Bladder: Unique Magnetic Resonance Imaging. ( 27413571 )
2016
26
Pediatric intraocular immature teratoma associated with sacrococcygeal teratoma: case report and review of the literature. ( 27385488 )
2016
27
Hemorrhage is the most common cause of neonatal mortality in patients with sacrococcygeal teratoma. ( 27502009 )
2016
28
Benign sacrococcygeal teratoma incidentally found on routine scoliosis radiographs in a 12-year-old female: a case report. ( 27069263 )
2016
29
Patient-Reported Defecation and Micturition Problems Among Adults Treated for Sacrococcygeal Teratoma During Childhood-The Need for New Surveillance Strategies. ( 26739142 )
2016
30
Anaesthestic management of sacrococcygeal teratoma in infants. ( 27212735 )
2016
31
Sacrococcygeal Teratoma associated with Trisomy 13. ( 27398323 )
2016
32
Evaluation of chemotherapeutic sequelae and quality of life in survivors of malignant sacrococcygeal teratoma. ( 26667016 )
2016
33
VACTERL Association with Sacrococcygeal Teratoma. ( 27567656 )
2016
34
Adult Sacrococcygeal Teratoma: The third leg: A rare case report in a 25 year old man. ( 26275739 )
2015
35
Benign and Infected Sacrococcygeal Teratoma in a 13-year-old Girl. ( 26064810 )
2015
36
Sacrococcygeal teratoma: A population-based study of incidence and prenatal prognostic factors. ( 26454470 )
2015
37
Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review. ( 25783370 )
2015
38
Sacrococcygeal teratoma in a female newborn with clinical features of trisomy 13: a case report from Central Africa. ( 26715863 )
2015
39
Cornelia de Lange syndrome due to mosaic NIPBL mutation: antenatal presentation with sacrococcygeal teratoma. ( 26276849 )
2015
40
Sacrococcygeal Teratoma with Yolk Sac Component in a Neonate. ( 26290815 )
2015
41
Sacrococcygeal teratoma with complete adrenal gland. ( 26881658 )
2015
42
Laparoscopic Approach to Type IV Sacrococcygeal Teratoma in an Adult. ( 25972646 )
2015
43
Sacrococcygeal teratoma with ectopic immature renal tissue. ( 25673616 )
2015
44
Sacrococcygeal teratoma: case report. ( 26079985 )
2015
45
A Huge Fetal Sacrococcygeal Teratoma with a Vascular Disruption Sequence. ( 26029981 )
2015
46
Multi-stage resection and repair for the treatment of adult giant sacrococcygeal teratoma: A case report and literature review. ( 26171044 )
2015
47
Quality of life in adulthood after resection of a sacrococcygeal teratoma in childhood: a Dutch multicentre study. ( 25634960 )
2015
48
Sexual function after treatment for sacrococcygeal teratoma during childhood. ( 26460155 )
2015
49
The first description of metyrapone use in severe Cushing Syndrome due to ectopic ACTH secretion in an infant with immature sacrococcygeal teratoma. Case Report. ( 26859587 )
2015
50
Sonographic features of congenital infantile fibrosarcoma that appeared as a sacrococcygeal teratoma during pregnancy. ( 26013636 )
2015

Variations for Sacrococcygeal Teratoma

Expression for Sacrococcygeal Teratoma

Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for Sacrococcygeal Teratoma

Pathways related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 AFP CGA

GO Terms for Sacrococcygeal Teratoma

Biological processes related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 8.62 CGA CGB7

Molecular functions related to Sacrococcygeal Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CGA CGB7

Sources for Sacrococcygeal Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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