MCID: SCR024
MIFTS: 42

Sacrococcygeal Teratoma malady

Summaries for Sacrococcygeal Teratoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A sacrococcygeal teratoma is a tumor that grows at the base of the spine in a developing fetus.  it occurs in one in 40,000 newborns and girls are four times more likely to be affected than boys.  though it is usually benign, there is a possibility that the teratoma could become malignant.  as such, the recommended treatment of a teratoma is complete removal of the tumor by surgery, performed soon after the birth.  if not all of the tumor is removed during the initial surgery, the teratoma may grow back (recur) and additional surgeries may be needed.  studies have found that sacrococcygeal teratomas recur in up to 22% of cases. last updated: 10/18/2013

MalaCards: Sacrococcygeal Teratoma is related to teratoma and adenocarcinoma. An important gene associated with Sacrococcygeal Teratoma is MNX1 (motor neuron and pancreas homeobox 1), and among its related pathways are Human Early Embryo Development and Oct4 in Mammalian ESC Pluripotency. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and liver, and related mouse phenotypes are reproductive system and digestive/alimentary.

Wikipedia:64 Sacrococcygeal teratoma (SCT) is a teratoma (a kind of tumor) located at the base of the coccyx... more...

Aliases & Classifications for Sacrococcygeal Teratoma

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

sacrococcygeal teratoma 43 61


Related Diseases for Sacrococcygeal Teratoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sacrococcygeal Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma32.1POU5F1, CGA, CGB7, AFP, GFAP, NANOG
2adenocarcinoma30.4PCNA, MUC16, AFP, CGB7
3wilms tumor30.2GDNF
4adult teratoma10.7
5hydrops fetalis10.4
6schinzel giedion syndrome10.4
7klippel-trenaunay syndrome10.1
8neuroendocrine carcinoma10.1
9sotos syndrome10.1
10proteus syndrome10.1
11hydronephrosis10.1
12cushing's syndrome10.1
13gastroschisis10.1
14neurogenic bladder10.1
15pseudomyxoma peritonei10.1
16plexiform neurofibroma10.1
17meningocele10.1
18congenital fibrosarcoma10.1
19autoimmune hemolytic anemia10.1
20cauda equina syndrome10.1
21congenital diaphragmatic hernia10.1
22spina bifida10.1
23squamous cell carcinoma10.1
24ring chromosome 210.1
25ring chromosome 2010.1
26currarino triad10.1
27lipomyelomeningocele10.1
28weber syndrome10.1
29sotos syndrome 110.1
30hypogonadism, hypergonadotropic10.1
31epignathus10.1
32fibular dimelia - diplopodia10.1
33myelocystocele10.1
34pituitary tumors10.0CGB7
35hepatitis10.0AFP
36meningitis10.0GDNF
37herpes simplex10.0GDNF
38familial medullary thyroid carcinoma10.0GDNF
39medulloblastoma10.0GFAP
40thyroiditis10.0CGA
41central hypoventilation syndrome10.0GDNF
42leydig cell tumor10.0CGA
43sertoli-leydig cell tumor10.0AFP
44myoepithelioma10.0GFAP
45oligohydramnios10.0AFP
46thyroid cancer10.0RET
47phaeochromocytoma10.0RET
48portal vein thrombosis10.0AFP
49omphalocele10.0AFP
50peritonitis10.0MUC16

Graphical network of the top 20 diseases related to Sacrococcygeal Teratoma:



Diseases related to sacrococcygeal teratoma

Clinical Features for Sacrococcygeal Teratoma

Drugs & Therapeutics for Sacrococcygeal Teratoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sacrococcygeal Teratoma

Drug clinical trials:

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Search NIH Clinical Center for Sacrococcygeal Teratoma

Search CenterWatch for Sacrococcygeal Teratoma

Genetic Tests for Sacrococcygeal Teratoma

Anatomical Context for Sacrococcygeal Teratoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Sacrococcygeal Teratoma:

33
Spinal cord, Heart, Liver, Lung, Thyroid, Placenta, Fetal liver, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Sacrococcygeal Teratoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Sacrococcygeal Teratoma

Sources:
51PubMed
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Articles related to Sacrococcygeal Teratoma:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. (24057924)
2013
2
Ultrasound and magnetic resonance imaging in prenatal diagnosis of sacrococcygeal teratoma--case report. (23888736)
2013
3
Ring chromosome 21 presenting with sacrococcygeal teratoma: prenatal diagnosis, molecular cytogenetic characterization and literature review. (23545316)
2013
4
Urogenital anomalies in girls with sacrococcygeal teratoma: a commonly missed association. (22325393)
2012
5
Postoperative bladder and rectal function in children with sacrococcygeal teratoma. (21061314)
2011
6
Type 2 sacrococcygeal teratoma endodermal sinus tumor. (22124518)
2011
7
Prenatal assessment and management of sacrococcygeal teratoma. (21656530)
2011
8
Enhancing safety of laparoscopic vascular control for neonatal sacrococcygeal teratoma. (21616227)
2011
9
Prenatal diagnosis and follow-up of giant sacrococcygeal teratoma. (21791320)
2011
10
Antenatal diagnosis of a sacrococcygeal teratoma. (21381532)
2010
11
Isolation of three stem cell lines from human sacrococcygeal teratomas. (19142973)
2009
12
A sacrococcygeal teratoma or conjoint parasitic twin: a diagnostic dilemma. (18604745)
2008
13
Sacrococcygeal teratoma in a fetus with prenatally diagnosed partial trisomy 10q (10q24.3-->qter) and partial monosomy 17p (p13.3-->pter). (17295347)
2007
14
Management of sacrococcygeal teratoma of the fetus. (15321048)
2004
15
Mature sacrococcygeal teratoma: a case report and literature review. (15287301)
2004
16
Intra-pelvic sacrococcygeal teratoma. (12892177)
2003
17
Sacrococcygeal teratoma: 25 year experience. (11336088)
2001
18
Three-dimensional prenatal ultrasound study of a large sacrococcygeal teratoma. (11336723)
2001
19
Ultrafast fetal MR images of sacrococcygeal teratoma: a case report. (10739323)
2000
20
Picture of the month. Sacrococcygeal teratoma. (10710034)
2000
21
Congenital sacrococcygeal teratomas: effect of gestational age on size, morphologic pattern, ploidy, p53, and ret expression. (10742411)
2000
22
Sonographic prognostic factors in fetuses with sacrococcygeal teratoma. (10693688)
2000
23
Huge fetal sacrococcygeal teratoma with a completely formed eye and intratumoral DNA ploidy heterogeneity. (9841706)
1999
24
Fetal sacrococcygeal teratoma visualized by ultra-fast T2 weighted magnetic resonance imaging. (10405065)
1999
25
Prenatal diagnosis and perinatal management of fetal sacrococcygeal teratoma. (10355916)
1999
26
Prenatal diagnosis and perinatal management of fetal sacrococcygeal teratoma. (9788651)
1998
27
Sacrococcygeal teratoma associated with a normal alpha-fetoprotein concentration. (9286870)
1997
28
Maternal serum alpha-fetoprotein and epithelial tumour marker concentrations are not increased by fetal sacrococcygeal teratoma. (9021828)
1997
29
Amplitude-based color Doppler sonography of fetus with sacrococcygeal teratoma. (8908590)
1996
30
Proteus syndrome associated with a sacrococcygeal teratoma; a rare combination. (8877364)
1996
31
Yolk sac tumor identified at autopsy after surgical excision of immature sacrococcygeal teratoma. (7666328)
1995
32
The newborn with hydrops and sacrococcygeal teratoma. (1765933)
1991
33
Giant adult malignant sacrococcygeal teratoma. Successful treatment by combined abdominosacral resection. (2058849)
1991
34
Antenatal diagnosis of sacrococcygeal teratoma facilitated by combined use of Doppler sonography and MR imaging. (2017947)
1991
35
Prenatal sonographic diagnosis of congenital sacrococcygeal teratoma and management. (2681670)
1989
36
Sacrococcygeal teratoma in children: case report and review. (2691592)
1989
37
Prenatal diagnosis of sacrococcygeal teratoma: sonographic-pathologic correlation. (3047782)
1988
38
Ruptured sacrococcygeal teratoma in a newborn: a case report. (3440046)
1987
39
Sacrococcygeal teratoma. (4038215)
1985
40
Embryonal adenocarcinoma in sacrococcygeal teratoma. (6282977)
1981
41
Prenatal diagnosis of sacrococcygeal teratoma. (377967)
1979
42
Malignant sacrococcygeal teratoma. A case report. (4664504)
1972
43
Sacrococcygeal teratoma of the fetus complicating pregnancy. (4914441)
1970
44
BENIGN FETAL SACROCOCCYGEAL TERATOMA ASSOCIATED WITH HYDRAMNIOS AND PREMATURE LABOR: REPORT OF A CASE. (14168256)
1964
45
A case of sacrococcygeal teratoma with review of the literature. (13893559)
1961
46
Sacrococcygeal teratoma in the adult. A case report. (13768789)
1960
47
Sacrococcygeal teratoma in the newborn: report of a case. (13668667)
1959
48
A case of malignant sacrococcygeal teratoma. (13576405)
1958
49
Sacrococcygeal teratoma with urinary retention. (15403717)
1950
50
Sacrococcygeal teratoma. (18902813)
1948

Genetic Variations for Sacrococcygeal Teratoma

Expression for genes affiliated with Sacrococcygeal Teratoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sacrococcygeal Teratoma

Search GEO for disease gene expression data for Sacrococcygeal Teratoma.

Pathways for genes affiliated with Sacrococcygeal Teratoma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome, 12EMD Millipore
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Compounds for genes affiliated with Sacrococcygeal Teratoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6GFAP
2butyrate4510.5GFAP
3tachyplesin i4510.0PCNA, AFP
4ganciclovir45 1110.9AFP, RET
5eosin459.9GFAP, PCNA
6forskolin45 50 1111.8GDNF, GFAP
7oestriol459.8CGA, CGB7, AFP
88-bromo-cyclic amp459.8GFAP, CGA
9dbc-amp459.7CGA, GFAP, GDNF
10vinblastine45 50 1111.7CGA, AFP, JUN
11etoposide45 50 60 1112.7JUN, CGB7, AFP
12dopamine45 29 11 2412.7PCNA, GDNF, GFAP
13bleomycin45 1110.6CGA, CGB7, AFP
14mifepristone45 60 29 1112.6AFP, CGA, JUN
15silver459.6AFP, GFAP, PCNA
16polyethylene glycol459.6PCNA, AFP, GFAP
17glutamate459.5GFAP, GDNF, CGA
18kainate45 2910.5JUN, GFAP, GDNF
19alpha-amanitin459.4GFAP, JUN
20paclitaxel45 50 1111.3GFAP, AFP, MUC16
21actinomycin d459.3CGA, AFP, GDNF, JUN
22carboplatin45 50 1111.3AFP, MUC16, CGA
23cytarabine45 50 1111.3GFAP, JUN, PCNA
24thyroxine45 2410.2CGB7, AFP, PCNA, CGA
25b 723459.2AFP, MUC16, PCNA
26methotrexate45 50 1111.2CGB7, CGA, PCNA, AFP
27agar459.2RET, GFAP, AFP, JUN
28hematoxylin459.1GFAP, MUC16, PCNA
29pd 98,059459.0GDNF, RET, GFAP, JUN
30cyclophosphamide45 50 1110.9PCNA, CGA, AFP, MUC16
31cyclic amp45 249.8CGA, JUN, GFAP, RET, GDNF
32genistein45 29 60 2 11 2413.7PCNA, JUN, GFAP, GDNF, RET
33oligonucleotide458.6PCNA, RET, GDNF, AFP, JUN
34iron45 249.6GDNF, GFAP, MUC16, AFP
35aspartate458.4PCNA, RET, AFP, CGA, GFAP, GDNF
36creatinine458.2GFAP, PCNA, GDNF, MUC16, AFP, CGA
37cysteine458.2JUN, CGB7, PCNA, GDNF, GFAP, RET
38dexamethasone45 50 29 1111.2AFP, PCNA, JUN, GDNF, GFAP, MUC16
39alanine458.2AFP, GFAP, PCNA, GDNF, MNX1, CGA
40threonine458.2GFAP, AFP, JUN, RET, MUC16
41h2o2458.1GDNF, MUC16, PCNA, AFP, CGA, JUN
42estradiol45 11 2410.1PCNA, GFAP, AFP, CGB7, CGA, MUC16
43lactate458.1CGB7, CGA, MUC16, AFP, GFAP, PCNA
44cisplatin45 50 60 1111.1AFP, CGB7, MUC16, PCNA, CGA, GFAP
45progesterone45 60 29 11 2412.1CGA, PCNA, GFAP, AFP, MUC16, CGB7
46paraffin457.9PCNA, RET, AFP, GFAP, MUC16, CGA
47serine457.7AFP, JUN, MUC16, RET, GDNF, GFAP
48testosterone45 60 11 2410.5AFP, GFAP, CGB7, CGA, RET, PCNA
49retinoic acid45 248.4GDNF, JUN, CGB7, AFP, POU5F1, MNX1
50vegf456.9GFAP, GDNF, RET, PCNA, MUC16, POU5F1

GO Terms for genes affiliated with Sacrococcygeal Teratoma

Sources:
16Gene Ontology
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Biological processes related to Sacrococcygeal Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endodermal cell fate specificationGO:0017149.7NANOG, POU5F1
2SMAD protein signal transductionGO:0603959.7AFP, JUN
3gonad developmentGO:0084069.6NANOG, CGA
4enteric nervous system developmentGO:0484849.2RET, GDNF
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.6JUN, CGA, POU5F1, GDNF, NANOG

Products for genes affiliated with Sacrococcygeal Teratoma

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Sources for Sacrococcygeal Teratoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet