MCID: SGT001
MIFTS: 45

Sagittal Sinus Thrombosis malady

Blood diseases category

Summaries for Sagittal Sinus Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cerebral venous sinus thrombosis (CVST) is the presence of thrombosis (a blood clot) in the dural venous... more...

MalaCards: Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to intracranial thrombosis and protein s deficiency. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Platelet degranulation and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds heparin and hirugen have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are cardiovascular system and embryogenesis.

Aliases & Classifications for Sagittal Sinus Thrombosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

sagittal sinus thrombosis 8 10 44 60
thrombosis of superior longitudinal sinus 8
thrombosis of superior sagittal sinus 8
thrombosis superior sagittal sinus 44


External Ids:

Disease Ontology8 DOID:3576
SNOMED-CT56 192760003, 70607008
MeSH34 D020225

Related Diseases for Sagittal Sinus Thrombosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1intracranial thrombosis31.0SERPINC1, F3, F5
2protein s deficiency30.9F5, SERPINC1
3nephrotic syndrome30.9SERPINC1
4homocystinuria30.7SERPINC1, F5
5hypertension30.7PROS1, F5
6thrombocytopenia30.6F5, F3, SERPINC1
7protein c deficiency30.6F5, PROS1, SERPINC1
8antithrombin iii deficiency30.5F5, PROS1, SERPINC1
9pulmonary embolism30.5SERPINC1, F3, PROS1, F5
10antiphospholipid syndrome30.5SERPINC1, F3, PROS1, F5
11lupus erythematosus30.5SERPINC1, F3, PROS1, F5
12purpura30.3SERPINC1
13factor vii deficiency30.2F5, F3, SERPINC1
14intracranial sinus thrombosis10.7
15cerebritis10.5
16intracranial hypertension10.5
17leukemia10.5
18ulcerative colitis10.4
19acute leukemia10.4
20lymphoblastic leukemia10.4
21systemic lupus erythematosus10.3
22cortical blindness10.3
23hyperthyroidism10.3
24thyrotoxicosis10.3
25deficiency anemia10.2
26arteriovenous fistula10.2
27moyamoya disease10.2
28crohn's disease10.2
29evans' syndrome10.2
30pseudotumor cerebri10.2
31cellulitis10.2
32wegener's granulomatosis10.2
33intracranial hypotension10.2
34hemoglobinuria10.2
35bone lymphoma10.2
36iron deficiency anemia10.2
37acquired immunodeficiency syndrome10.2
38tetralogy of fallot10.2
39burkitt's lymphoma10.2
40trichinosis10.2
41adult syndrome10.2
42typhoid fever10.2
43behcet's disease10.2
44down syndrome10.2
45adenocarcinoma10.2
46aplastic anemia10.2
47cervical adenocarcinoma10.2
48cervicitis10.2
49frontal sinusitis10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to sagittal sinus thrombosis

Clinical Features for Sagittal Sinus Thrombosis

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Drugs & Therapeutics for Sagittal Sinus Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sagittal Sinus Thrombosis

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Anatomical Context for Sagittal Sinus Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

32
Brain, Bone marrow, Bone, Myeloid, T cells, B cells

Animal Models for Sagittal Sinus Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.7F3
2MP:00053807.8SERPINC1, F3, PROS1, F5

Publications for Sagittal Sinus Thrombosis

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50PubMed
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Articles related to Sagittal Sinus Thrombosis:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Superior sagittal sinus thrombosis as a treatment complication of nonsyndromic KleeblattschAodel. (24220397)
2013
2
Isolated inferior sagittal sinus thrombosis caused by a rare combination of elevated lipoprotein (a) and iron deficiency anemia. (23022905)
2012
3
An unusual case of transient cortical blindness with sagittal sinus thrombosis in a case of Henoch-Schonlein purpura. (22864046)
2012
4
Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis. (21746724)
2011
5
Pulmonary embolus from acute superior sagittal sinus thrombosis secondary to skull fracture: case report. (21389895)
2011
6
Sagittal sinus thrombosis due to L-asparaginase. (21042505)
2010
7
A case of superior sagittal sinus thrombosis in pregnancy despite prophylactic antenatal heparin. (21126134)
2010
8
Detection of superior sagittal sinus thrombosis on FDG PET. (19352280)
2009
9
Sagittal sinus thrombosis as a rare cause of postpartum headache: a case report]. (18853684)
2008
10
Superior sagittal sinus thrombosis: subtle signs on neuroimaging. (18536826)
2008
11
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
12
Is heparin treatment the optimal management for cerebral venous thrombosis? Effect of abciximab, recombinant tissue plasminogen activator, and enoxaparin in experimentally induced superior sagittal sinus thrombosis. (15731475)
2005
13
Extensive aplasia cutis congenita and the risk of sagittal sinus thrombosis. (15897375)
2005
14
Sagittal sinus thrombosis in a migraineur: differential diagnosis of headaches. (15255570)
2004
15
Superior sagittal sinus thrombosis in a patient with postdural puncture headache. (12567347)
2003
16
Superior sagittal sinus thrombosis induced by thyrotoxicosis. Case report. (11147882)
2001
17
Superior sagittal sinus thrombosis: a rare complication in a child with nephrotic syndrome. (11685439)
2001
18
Moyamoya disease and sagittal sinus thrombosis in a child with Down's syndrome. (11214682)
2001
19
Sagittal sinus thrombosis associated with thrombocytopenia: a report of two patients. (10465147)
1999
20
Treatment of acute superior sagittal sinus thrombosis by t-PA infusion via venography--direct thrombolytic therapy in the acute phase. (9537662)
1998
21
Sagittal sinus thrombosis following minor head injury treated with continuous urokinase infusion. (9537663)
1998
22
Superior sagittal sinus thrombosis treated with combined local thrombolytic and systemic anticoagulation therapy. (9202773)
1997
23
Successful Treatment of Superior Sagittal Sinus Thrombosis. Direct Thrombolysis with Local Infusion of t-PA via Venography in the Acute Phase. (20678418)
1997
24
Superior sagittal sinus thrombosis complicating maintenance treatment for acute lymphoblastic leukemia. (8735346)
1996
25
Transcranial color-coded real-time sonography of intracranial veins. Normal values of blood flow velocities and findings in superior sagittal sinus thrombosis. (7718947)
1995
26
Superior sagittal sinus thrombosis and thyrotoxicosis. Possible association in two cases. (7886732)
1995
27
Sumatriptan-induced stroke in sagittal sinus thrombosis. (7909130)
1994
28
Sumatriptan-induced [correction of Sumatripan] stroke in sagittal sinus thrombosis. (7910310)
1994
29
Superior sagittal sinus thrombosis in a patient with acquired immunodeficiency syndrome. (8060239)
1994
30
Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered. (1455986)
1992
31
Noninvasive diagnosis of superior sagittal sinus thrombosis in a neonate. (1575843)
1992
32
Superior sagittal sinus thrombosis following L-asparaginase therapy of acute lymphoblastic leukemia]. (1578639)
1992
33
Sagittal sinus thrombosis and leptomeningeal medulloblastoma. (2006021)
1991
34
Thrombolysis for superior sagittal sinus thrombosis. (1799753)
1991
35
Improvement in sagittal sinus thrombosis by MRI. (2012113)
1991
36
Posttraumatic septic superior sagittal sinus thrombosis: report of a case. (1995822)
1991
37
Superior sagittal sinus thrombosis. (1821832)
1991
38
Computed tomography appearances of sagittal sinus thrombosis in a neonate. (1989083)
1991
39
Superior sagittal sinus thrombosis in Wegener's granulomatosis. (2703849)
1989
40
Diagnosis of superior sagittal sinus thrombosis by three-dimensional magnetic resonance flow imaging. (2566040)
1989
41
Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. (3388462)
1988
42
Superior sagittal sinus thrombosis and systemic lupus erythematosus. (3752969)
1986
43
Progressive posttraumatic superior sagittal sinus thrombosis complicated by pulmonary embolism. Case report. (6689714)
1984
44
Superior sagittal sinus thrombosis and essential thrombocythaemia. (6416403)
1983
45
Benign intracranial hypertension, monoclonal gammopathy, and superior sagittal sinus thrombosis. (6844972)
1983
46
Superior sagittal sinus thrombosis followed by subdural hematoma. (7179076)
1982
47
Superior sagittal sinus thrombosis 10 years after surgery for ulcerative colitis. (7394868)
1980
48
Sagittal sinus thrombosis as a complication of regional enteritis. (727725)
1978
49
Superior sagittal sinus thrombosis: an evaluation of the changes demonstrated on computed tomography. (731250)
1978
50
Sagittal sinus thrombosis related to oral contraceptives. Case report. (5488802)
1970

Genetic Variations for Sagittal Sinus Thrombosis

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Expression for genes affiliated with Sagittal Sinus Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for genes affiliated with Sagittal Sinus Thrombosis

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53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Sagittal Sinus Thrombosis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.2PROS1
2hirugen449.8SERPINC1, F5
3nafamostat mesilate449.8SERPINC1, F5
4ancrod449.7SERPINC1, F5
5eltrombopag49 1110.7SERPINC1, F5
6celite449.6SERPINC1, F3
7certoparin449.6F3, SERPINC1
8dabigatran449.6SERPINC1, F3
9reviparin449.6SERPINC1, F3
10efegatran449.6SERPINC1, F3
11polybrene449.5SERPINC1, F3
12nadroparin44 1110.5F3, SERPINC1
13hepaplastin449.5F3, SERPINC1
14tinzaparin44 1110.5F3, SERPINC1
15organon449.5SERPINC1, F3
16rivaroxaban44 1110.4SERPINC1, F3
17kaolin449.4F5, F3
18vitamin k144 2410.3SERPINC1, F3
19Drotrecogin alfa119.3PROS1, F5
20acenocoumarol44 49 1111.2F5, F3
21hydroxyethyl starch449.2SERPINC1, F3
22inogatran449.1SERPINC1, F3, F5
23ecarin449.1F5, F3, SERPINC1
24spectrozyme449.1SERPINC1, F5, F3
25danaparoid449.1SERPINC1, F3, F5
26ximelagatran44 1110.1F5, F3, SERPINC1
27heparinoids449.1SERPINC1, F3, F5
28fondaparinux449.1SERPINC1, F5, F3
29bivalirudin44 1110.1F5, SERPINC1, F3
30argatroban44 1110.1F3, SERPINC1, F5
31protamine sulfate449.1F5, F3, SERPINC1
32ristocetin449.1F3, F5, SERPINC1
33levonorgestrel44 59 28 1112.1SERPINC1, F3, F5
34desmopressin44 59 28 1112.1SERPINC1, F5, F3
35coumarin44 2 49 2412.1F5, F3, SERPINC1
36fluorescein44 1110.1F5, SERPINC1, F3
37hirudin449.1F5, SERPINC1, F3
38protamine449.1F3, F5, SERPINC1
39dermatan sulfate449.1F3, F5, SERPINC1
40dextran sulfate449.1F3, SERPINC1, F5
41warfarin44 49 11 2412.1F5, F3, SERPINC1
42kininogen449.0SERPINC1, F3, F5
43aprotinin44 1110.0F3, SERPINC1, F5
44homocysteine44 2410.0F3, F5, SERPINC1
45gamma-carboxyglutamic acid448.9PROS1, F5, F3
46phenprocoumon44 49 1110.9SERPINC1, F3
47citrate448.8SERPINC1, F3, F5
48creatinine448.4F5, SERPINC1, F3, PROS1
49prostacyclin448.0F5, PROS1, F3, SERPINC1, ASRGL1
50vegf448.0F3, PROS1, F5, SERPINC1

GO Terms for genes affiliated with Sagittal Sinus Thrombosis

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16Gene Ontology
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Cellular components related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3PROS1, F5

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.3PROS1, F5
2negative regulation of endopeptidase activityGO:0109519.1SERPINC1, PROS1
3blood coagulationGO:0075968.0SERPINC1, F3, PROS1, F5

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2SERPINC1, F3

Products for genes affiliated with Sagittal Sinus Thrombosis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Sagittal Sinus Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet