MCID: SGT001
MIFTS: 45

Sagittal Sinus Thrombosis malady

Blood diseases category

Summaries for Sagittal Sinus Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cerebral venous sinus thrombosis (CVST) is the presence of thrombosis (a blood clot) in the dural venous... more...

MalaCards: Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to intracranial thrombosis and protein s deficiency. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Platelet degranulation and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds heparin and hirugen have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are cardiovascular system and embryogenesis.

Aliases & Classifications for Sagittal Sinus Thrombosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

sagittal sinus thrombosis 8 10 44 60
thrombosis of superior longitudinal sinus 8
thrombosis of superior sagittal sinus 8
thrombosis superior sagittal sinus 44


External Ids:

Disease Ontology8 DOID:3576
SNOMED-CT56 192760003, 70607008
MeSH34 D020225

Related Diseases for Sagittal Sinus Thrombosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1intracranial thrombosis31.0SERPINC1, F3, F5
2protein s deficiency30.9F5, SERPINC1
3nephrotic syndrome30.9SERPINC1
4homocystinuria30.7SERPINC1, F5
5hypertension30.7PROS1, F5
6thrombocytopenia30.6F5, F3, SERPINC1
7protein c deficiency30.6F5, PROS1, SERPINC1
8antithrombin iii deficiency30.5F5, PROS1, SERPINC1
9pulmonary embolism30.5SERPINC1, F3, PROS1, F5
10antiphospholipid syndrome30.5SERPINC1, F3, PROS1, F5
11lupus erythematosus30.5SERPINC1, F3, PROS1, F5
12purpura30.3SERPINC1
13factor vii deficiency30.2F5, F3, SERPINC1
14intracranial sinus thrombosis10.7
15cerebritis10.5
16intracranial hypertension10.5
17leukemia10.5
18ulcerative colitis10.4
19acute leukemia10.4
20lymphoblastic leukemia10.4
21systemic lupus erythematosus10.3
22cortical blindness10.3
23hyperthyroidism10.3
24thyrotoxicosis10.3
25deficiency anemia10.2
26arteriovenous fistula10.2
27moyamoya disease10.2
28crohn's disease10.2
29evans' syndrome10.2
30pseudotumor cerebri10.2
31cellulitis10.2
32wegener's granulomatosis10.2
33intracranial hypotension10.2
34hemoglobinuria10.2
35bone lymphoma10.2
36iron deficiency anemia10.2
37acquired immunodeficiency syndrome10.2
38tetralogy of fallot10.2
39burkitt's lymphoma10.2
40trichinosis10.2
41adult syndrome10.2
42typhoid fever10.2
43behcet's disease10.2
44down syndrome10.2
45adenocarcinoma10.2
46aplastic anemia10.2
47cervical adenocarcinoma10.2
48cervicitis10.2
49frontal sinusitis10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to sagittal sinus thrombosis

Clinical Features for Sagittal Sinus Thrombosis

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Drugs & Therapeutics for Sagittal Sinus Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sagittal Sinus Thrombosis

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Anatomical Context for Sagittal Sinus Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

32
Brain, Bone, Bone marrow, Myeloid, T cells, B cells

Animal Models for Sagittal Sinus Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.7F3
2MP:00053807.8SERPINC1, F3, PROS1, F5

Publications for Sagittal Sinus Thrombosis

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50PubMed
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Articles related to Sagittal Sinus Thrombosis:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Post-traumatic sagittal sinus thrombosis: case report. (23588984)
2013
2
Acute presentation of sagittal sinus thrombosis following closed head injury without overlying fracture. (23307334)
2013
3
Sagittal sinus thrombosis while on tamoxifen requiring craniectomy. (22720357)
2012
4
Superior sagittal sinus thrombosis complicating typhoid Fever in a teenager. (23227403)
2012
5
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: superior sagittal sinus thrombosis. (21463850)
2011
6
Cortical blindness due to sagittal sinus thrombosis in acute lymphoblastic leukaemia. (19006563)
2009
7
Superior sagittal sinus thrombosis presenting as a continuous headache: a case report and review of the literature. (20062608)
2009
8
Chronic superior sagittal sinus thrombosis with phlebosclerotic changes of the subarachnoid and intracerebral veins. (16961069)
2006
9
Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen. (15989707)
2005
10
Post gravidic superior sagittal sinus thrombosis with elevated levels of homocystinemia. (15702064)
2004
11
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. (12162390)
2002
12
Late puerperal sagittal sinus thrombosis associated with primary antiphospholipid antibody syndrome. (12554264)
2002
13
Postpartum postural headache due to superior sagittal sinus thrombosis mistaken for spontaneous intracranial hypotension. (11305834)
2001
14
Neuroimaging highlight. Superior sagittal sinus thrombosis. (11766779)
2001
15
Ulcerative colitis with sagittal sinus thrombosis with normal coagulation profile. (10812827)
2000
16
Superior sagittal sinus thrombosis secondary to hyperthyroidism. (17895204)
2000
17
Superior sagittal sinus thrombosis occurring at high altitude associated with protein C deficiency. (10529516)
1999
18
Superior sagittal sinus thrombosis and transient ischemic attacks: possible mechanism. (9811193)
1998
19
Superior sagittal sinus thrombosis: a clinical and experimental study. (17171061)
1998
20
Superior sagittal sinus thrombosis in a patient heterozygous for the novel 20210 A allele of the prothrombin gene. (9459354)
1998
21
Myelodysplastic syndrome and sagittal sinus thrombosis. (17895084)
1998
22
Radiological case of the month. Sagittal sinus thrombosis in hypernatremic dehydration. (9811296)
1998
23
Superior sagittal sinus thrombosis in a patient with aplastic anemia treated with anabolic steroids. (9803681)
1998
24
Urokinase treatment of sagittal sinus thrombosis with venous hemorrhagic infarction. (17895121)
1998
25
Direct thrombolysis of superior sagittal sinus thrombosis with coexisting intracranial hemorrhage. (9282848)
1997
26
Superior sagittal sinus thrombosis with high-signal-intensity CSF mimicking subarachnoid hemorrhage on MR FLAIR images. (9308487)
1997
27
Superior sagittal sinus thrombosis in a child with nephrotic syndrome. (8703714)
1996
28
Superior sagittal sinus thrombosis and acquired free protein S deficiency in the elderly. (8571436)
1996
29
Neuroradiology case of the day. Sagittal sinus thrombosis with hemorrhagic venous infarct. (8659396)
1996
30
Homocystinuria presenting with sagittal sinus thrombosis in infancy. (8745393)
1996
31
Superior sagittal sinus thrombosis in the presence of idiopathic bilateral internal jugular vein stenosis. (8136582)
1994
32
Superior sagittal sinus thrombosis after radical neck dissection. (17170925)
1994
33
Fatal superior sagittal sinus thrombosis associated with internal jugular vein catheterization. (8267072)
1993
34
Case report: treatment of superior sagittal sinus thrombosis with urokinase. (1458880)
1992
35
Superior sagittal sinus thrombosis--an unexpected cause of papilloedema. (1295530)
1992
36
CSF hydrodynamics in superior sagittal sinus thrombosis. (1583513)
1992
37
Superior sagittal sinus thrombosis after internal jugular vein cannulation. (1931408)
1991
38
Cerebral venous and sagittal sinus thrombosis after transcallosal removal of a colloid cyst of the third ventricle: case report. (2320225)
1990
39
Direct thrombolytic therapy for superior sagittal sinus thrombosis. (2505559)
1989
40
A case of thrombosed aneurysm of the vein of Galen associated with superior sagittal sinus thrombosis. (2634086)
1989
41
Postoperative sagittal sinus thrombosis after spinal anesthesia. (3963444)
1986
42
Demonstration of superior sagittal sinus thrombosis by indium-111 platelet scintigraphy. (3753267)
1986
43
Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia. (4056835)
1985
44
Superior sagittal sinus thrombosis after closed head injury. (3892357)
1985
45
Sagittal sinus thrombosis and occult malignancy. (6842227)
1983
46
Trichinosis associated with superior sagittal sinus thrombosis. (7073258)
1982
47
Sagittal sinus thrombosis in early pregnancy. (7088432)
1982
48
Puerperal superior sagittal sinus thrombosis. (7162448)
1982
49
Superior Sagittal Sinus Thrombosis. (831684)
1977
50
Septic superior sagittal sinus thrombosis after oral surgery. (4513469)
1973

Genetic Variations for Sagittal Sinus Thrombosis

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Expression for genes affiliated with Sagittal Sinus Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for genes affiliated with Sagittal Sinus Thrombosis

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Sagittal Sinus Thrombosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.2PROS1
2hirugen449.8SERPINC1, F5
3nafamostat mesilate449.8F5, SERPINC1
4ancrod449.8F5, SERPINC1
5eltrombopag49 1110.8SERPINC1, F5
6coumarins449.7F3
7celite449.6F3, SERPINC1
8certoparin449.6F3, SERPINC1
9reviparin449.6F3, SERPINC1
10dabigatran449.6F3, SERPINC1
11efegatran449.6SERPINC1, F3
12nadroparin44 1110.5SERPINC1, F3
13polybrene449.5SERPINC1, F3
14hepaplastin449.5F3, SERPINC1
15organon449.4F3, SERPINC1
16tinzaparin44 1110.4F3, SERPINC1
17Drotrecogin alfa119.4F5, PROS1
18rivaroxaban44 1110.4F3, SERPINC1
19kaolin449.4F3, F5
20vitamin k144 2410.3F3, SERPINC1
21acenocoumarol44 49 1111.1F5, F3
22inogatran449.1F5, F3, SERPINC1
23ecarin449.1SERPINC1, F3, F5
24spectrozyme449.1SERPINC1, F3, F5
25danaparoid449.1F5, F3, SERPINC1
26ximelagatran44 1110.1SERPINC1, F3, F5
27heparinoids449.1SERPINC1, F3, F5
28fondaparinux449.1F5, F3, SERPINC1
29bivalirudin44 1110.1SERPINC1, F3, F5
30argatroban44 1110.1SERPINC1, F3, F5
31protamine sulfate449.1F5, F3, SERPINC1
32ristocetin449.1SERPINC1, F3, F5
33levonorgestrel44 59 28 1112.1SERPINC1, F3, F5
34coumarin44 2 49 2412.1F5, F3, SERPINC1
35desmopressin44 59 28 1112.1F5, F3, SERPINC1
36fluorescein44 1110.1F5, F3, SERPINC1
37hirudin449.1SERPINC1, F3, F5
38protamine449.1SERPINC1, F3, F5
39dermatan sulfate449.1SERPINC1, F3, F5
40dextran sulfate449.1F5, F3, SERPINC1
41warfarin44 49 11 2412.1SERPINC1, F3, F5
42kininogen449.0SERPINC1, F3, F5
43aprotinin44 1110.0F5, F3, SERPINC1
44homocysteine44 2410.0SERPINC1, F3, F5
45gamma-carboxyglutamic acid448.9F5, PROS1, F3
46hydroxyethyl starch448.9SERPINC1, F3
47citrate448.8SERPINC1, F3, F5
48creatinine448.4SERPINC1, F3, PROS1, F5
49prostacyclin448.0ASRGL1, SERPINC1, F3, PROS1, F5
50vegf448.0SERPINC1, F3, PROS1, F5

GO Terms for genes affiliated with Sagittal Sinus Thrombosis

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16Gene Ontology
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Cellular components related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3PROS1, F5

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.3PROS1, F5
2negative regulation of endopeptidase activityGO:0109519.1SERPINC1, PROS1
3blood coagulationGO:0075968.0SERPINC1, F3, PROS1, F5

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2SERPINC1, F3

Products for genes affiliated with Sagittal Sinus Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sagittal Sinus Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet