MCID: SGT001
MIFTS: 49

Sagittal Sinus Thrombosis malady

Cardiovascular diseases, Blood diseases categories
Download this MalaCard

Summaries for Sagittal Sinus Thrombosis

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Cerebral venous sinus thrombosis (CVST) is the presence of thrombosis (a blood clot) in the dural venous... more...

MalaCards: Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to protein s deficiency and homocystinuria. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hemostasis. The compounds hirugen and nafamostat mesilate have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Sagittal Sinus Thrombosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

sagittal sinus thrombosis 8 10 45 62
thrombosis of superior longitudinal sinus 8
thrombosis of superior sagittal sinus 8
thrombosis superior sagittal sinus 45


External Ids:

Disease Ontology8 DOID:3576
SNOMED-CT58 70607008, 192760003
MeSH35 D020225

Related Diseases for Sagittal Sinus Thrombosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1protein s deficiency31.0SERPINC1, F5
2homocystinuria30.8F5, SERPINC1
3hypertension30.8PROS1, F5
4thrombocytopenia30.6F5, F3, SERPINC1
5protein c deficiency30.5F5, PROS1, SERPINC1
6purpura30.5SERPINC1
7pulmonary embolism30.4PROS1, F3, F5, SERPINC1
8lupus erythematosus30.4SERPINC1, PROS1, F3, F5
9antithrombin iii deficiency30.3F5, PROS1, SERPINC1
10thromboembolism30.3F5, F3, SERPINC1
11antiphospholipid syndrome30.2F3, F5, PROS1, SERPINC1
12venous thrombosis30.2F5, PROS1, SERPINC1, F3
13nephrotic syndrome10.7
14head injury10.6
15cerebritis10.6
16headache10.6
17intracranial hypertension10.5
18leukemia10.5
19ulcerative colitis10.5
20lymphoblastic leukemia10.5
21cortical blindness10.4
22systemic lupus erythematosus10.4
23hyperthyroidism10.4
24thyrotoxicosis10.4
25heparin-induced thrombocytopenia10.4
26blindness10.4
27deficiency anemia10.2
28arteriovenous fistula10.2
29crohn's disease10.2
30evans' syndrome10.2
31hemoglobinuria10.2
32iron deficiency anemia10.2
33acquired immunodeficiency syndrome10.2
34tetralogy of fallot10.2
35burkitt's lymphoma10.2
36trichinosis10.2
37pseudotumor cerebri10.2
38wegener's granulomatosis10.2
39intracranial hypotension10.2
40down syndrome10.2
41behcet's disease10.2
42typhoid fever10.2
43moyamoya disease10.2
44adenocarcinoma10.2
45aplastic anemia10.2
46cellulitis10.2
47cervical adenocarcinoma10.2
48cervicitis10.2
49frontal sinusitis10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to sagittal sinus thrombosis

Symptoms for Sagittal Sinus Thrombosis

About this section

Drugs & Therapeutics for Sagittal Sinus Thrombosis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Sagittal Sinus Thrombosis

Search NIH Clinical Center for Sagittal Sinus Thrombosis

Genetic Tests for Sagittal Sinus Thrombosis

About this section

Anatomical Context for Sagittal Sinus Thrombosis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

33
Brain, Bone, Bone marrow, Myeloid, T cells, B cells

Animal Models for Sagittal Sinus Thrombosis or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7F5, PROS1, SERPINC1
2MP:00107718.5F5, F3, PROS1
3MP:00053808.1F5, F3, PROS1, SERPINC1
4MP:00053858.1SERPINC1, PROS1, F3, F5
5MP:00036318.1F5, F3, PROS1, SERPINC1
6MP:00053768.0SERPINC1, PROS1, F3, F5
7MP:00107687.7SERPINC1, PROS1, F3, F5

Publications for Sagittal Sinus Thrombosis

About this section
Sources:
52PubMed
See all sources

Articles related to Sagittal Sinus Thrombosis:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Right Atrial Thrombosis associated with Sagittal Sinus Thrombosis caused by Protein C-S Deficiency. (24362664)
2013
2
Acquired Pial and Dural Arteriovenous Fistulae following Superior Sagittal Sinus Thrombosis in Patients with Protein S Deficiency: A Report of Two Cases. (24162240)
2013
3
Sagittal sinus thrombosis while on tamoxifen requiring craniectomy. (22720357)
2012
4
Periorbital cellulitis, subgaleal abscess and superior sagittal sinus thrombosis: a rare combination of complications arising from unilateral frontal sinusitis. (23020898)
2012
5
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: superior sagittal sinus thrombosis. (21463850)
2011
6
Cortical blindness due to sagittal sinus thrombosis in acute lymphoblastic leukaemia. (19006563)
2009
7
Detection of superior sagittal sinus thrombosis on FDG PET. (19352280)
2009
8
Sagittal sinus thrombosis as a rare cause of postpartum headache: a case report]. (18853684)
2008
9
Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case. (18373834)
2008
10
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
11
Corpus callosum hematoma secondary to isolated inferior sagittal sinus thrombosis. (17135013)
2006
12
Recurrent sagittal sinus thrombosis occurring at high altitude during expeditions to Cho Oyu. (16805150)
2006
13
Superior sagittal sinus thrombosis in steroid-resistant nephrotic syndrome. (15797188)
2005
14
Superior sagittal sinus thrombosis, an unusual presentation of acute myeloid leukaemia: a case report. (16046766)
2005
15
Is heparin treatment the optimal management for cerebral venous thrombosis? Effect of abciximab, recombinant tissue plasminogen activator, and enoxaparin in experimentally induced superior sagittal sinus thrombosis. (15731475)
2005
16
Sagittal sinus thrombosis in a migraineur: differential diagnosis of headaches. (15255570)
2004
17
Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: case report. (14585890)
2003
18
Superior sagittal sinus thrombosis in a patient with postdural puncture headache. (12567347)
2003
19
Post-traumatic superior sagittal sinus thrombosis. Case report and analysis of the international literature. (14743123)
2003
20
Superior sagittal sinus thrombosis in a child with Down syndrome. (12654149)
2003
21
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. (12162390)
2002
22
Superior sagittal sinus thrombosis and HIV. (12204043)
2002
23
Postpartum postural headache due to superior sagittal sinus thrombosis mistaken for spontaneous intracranial hypotension. (11305834)
2001
24
Superior sagittal sinus thrombosis induced by thyrotoxicosis. Case report. (11147882)
2001
25
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature. (10717401)
2000
26
Neuroradiology case of the day. Superior sagittal sinus thrombosis and infarcts. (10464815)
1999
27
Expansion of a haematoma after urokinase thrombolysis of superior sagittal sinus thrombosis. (20678374)
1997
28
Sagittal sinus thrombosis in adult minimal change nephrotic syndrome. (8846526)
1996
29
Superior sagittal sinus thrombosis in a child with nephrotic syndrome. (8703714)
1996
30
Superior sagittal sinus thrombosis and acquired free protein S deficiency in the elderly. (8571436)
1996
31
Neuroradiology case of the day. Sagittal sinus thrombosis with hemorrhagic venous infarct. (8659396)
1996
32
Sumatriptan-induced stroke in sagittal sinus thrombosis. (7909130)
1994
33
Sumatriptan-induced [correction of Sumatripan] stroke in sagittal sinus thrombosis. (7910310)
1994
34
Fatal superior sagittal sinus thrombosis associated with internal jugular vein catheterization. (8267072)
1993
35
Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered. (1455986)
1992
36
Noninvasive diagnosis of superior sagittal sinus thrombosis in a neonate. (1575843)
1992
37
Sagittal sinus thrombosis and leptomeningeal medulloblastoma. (2006021)
1991
38
Superior sagittal sinus thrombosis in blastic crisis of chronic myelogenous leukemia--a case report of a complete recovery. (1865591)
1991
39
Superior sagittal sinus thrombosis after internal jugular vein cannulation. (1931408)
1991
40
Thrombolysis for superior sagittal sinus thrombosis. (1799753)
1991
41
Cerebral venous and sagittal sinus thrombosis after transcallosal removal of a colloid cyst of the third ventricle: case report. (2320225)
1990
42
Direct thrombolytic therapy for superior sagittal sinus thrombosis. (2505559)
1989
43
Superior sagittal sinus thrombosis in Wegener's granulomatosis. (2703849)
1989
44
A case of thrombosed aneurysm of the vein of Galen associated with superior sagittal sinus thrombosis. (2634086)
1989
45
Superior sagittal sinus thrombosis: neuroradiological evaluation and clinical findings. (3772409)
1986
46
Experimental production of superior sagittal sinus thrombosis in the dog. (3918416)
1985
47
Superior sagittal sinus thrombosis and essential thrombocythaemia. (6416403)
1983
48
Superior sagittal sinus thrombosis followed by subdural hematoma. (7179076)
1982
49
Nonmetastatic superior sagittal sinus thrombosis complicating systemic cancer. (285338)
1979
50
Superior Sagittal Sinus Thrombosis. (831684)
1977

Variations for Sagittal Sinus Thrombosis

About this section

Expression for genes affiliated with Sagittal Sinus Thrombosis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for genes affiliated with Sagittal Sinus Thrombosis

About this section
Sources:
50PathCards, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems
See all sources

Compounds for genes affiliated with Sagittal Sinus Thrombosis

About this section
Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
See all sources

Compounds related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1hirugen459.7F5, SERPINC1
2nafamostat mesilate459.6SERPINC1, F5
3ancrod459.6F5, SERPINC1
4celite459.5SERPINC1, F3
5certoparin459.5SERPINC1, F3
6reviparin459.5F3, SERPINC1
7dabigatran51 4510.5F3, SERPINC1
8efegatran459.5SERPINC1, F3
9polybrene459.4SERPINC1, F3
10nadroparin45 1110.4SERPINC1, F3
11hepaplastin459.4F3, SERPINC1
12organon459.4SERPINC1, F3
13tinzaparin45 1110.3SERPINC1, F3
14rivaroxaban45 1110.3F3, SERPINC1
15vitamin k145 2410.2SERPINC1, F3
16kaolin459.2F3, F5
17hydroxyethyl starch459.1SERPINC1, F3
18acenocoumarol45 51 1111.0F5, F3
19desogestrel45 1110.0SERPINC1, F5
20inogatran459.0SERPINC1, F5, F3
21ecarin459.0SERPINC1, F3, F5
22spectrozyme459.0F3, SERPINC1, F5
23danaparoid459.0F5, F3, SERPINC1
24ximelagatran45 1110.0F3, SERPINC1, F5
25heparinoids459.0F3, F5, SERPINC1
26fondaparinux458.9F5, SERPINC1, F3
27bivalirudin45 119.9F3, F5, SERPINC1
28argatroban45 119.9F3, F5, SERPINC1
29protamine sulfate458.9F3, SERPINC1, F5
30ristocetin458.9F5, F3, SERPINC1
31coumarins458.9F5, F3
32gamma-carboxyglutamic acid458.9F3, PROS1, F5
33levonorgestrel45 61 29 1111.9F5, F3, SERPINC1
34coumarin45 3 51 2411.9SERPINC1, F3, F5
35desmopressin45 61 29 1111.9F5, F3, SERPINC1
36fluorescein45 119.9F5, F3, SERPINC1
37hirudin458.9F5, F3, SERPINC1
38protamine458.9F5, SERPINC1, F3
39dermatan sulfate458.9SERPINC1, F3, F5
40dextran sulfate458.9SERPINC1, F3, F5
41warfarin45 51 24 1111.9F5, F3, SERPINC1
42kininogen458.9F5, SERPINC1, F3
43aprotinin45 119.9F5, F3, SERPINC1
44homocysteine45 249.8F3, SERPINC1, F5
45citrate458.8SERPINC1, F5, F3
46aspirin45 51 29 2411.6F5, SERPINC1, F3
47prostacyclin458.4F5, SERPINC1, F3, PROS1
48creatinine458.4F3, F5, PROS1, SERPINC1
49heparin45 29 24 1111.4F3, SERPINC1, F5, PROS1
50vegf458.3F3, F5, SERPINC1, PROS1

GO Terms for genes affiliated with Sagittal Sinus Thrombosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3PROS1, F5
2blood microparticleGO:0725629.3SERPINC1, PROS1
3extracellular regionGO:0055768.8SERPINC1, PROS1, F5
4extracellular spaceGO:0056158.2SERPINC1, F3, F5

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3F5, PROS1
2platelet degranulationGO:0025769.2F5, PROS1
3negative regulation of endopeptidase activityGO:0109519.1PROS1, SERPINC1
4blood coagulationGO:0075968.0SERPINC1, F5, F3, PROS1

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1F3, SERPINC1

Products for genes affiliated with Sagittal Sinus Thrombosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sagittal Sinus Thrombosis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet