MCID: SGT001
MIFTS: 43

Sagittal Sinus Thrombosis malady

Blood category

Summaries for Sagittal Sinus Thrombosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cerebral venous sinus thrombosis (CVST) is the presence of thrombosis (a blood clot) in the dural venous... more...

MalaCards: Sagittal Sinus Thrombosis, also known as thrombosis of superior longitudinal sinus, is related to protein s deficiency and protein c deficiency. An important gene associated with Sagittal Sinus Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Platelet degranulation and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds heparin and hirugen have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and myeloid, and related mouse phenotypes are cardiovascular system and embryogenesis.

Aliases & Classifications for Sagittal Sinus Thrombosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

sagittal sinus thrombosis 8 10 45 61
thrombosis of superior longitudinal sinus 8
thrombosis of superior sagittal sinus 8
thrombosis superior sagittal sinus 45


External Ids:

Disease Ontology8 DOID:3576
SNOMED-CT57 192760003, 70607008
MeSH35 D020225

Related Diseases for Sagittal Sinus Thrombosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sagittal Sinus Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1protein s deficiency31.0F5, SERPINC1
2protein c deficiency30.9F5, PROS1, SERPINC1
3homocystinuria30.7SERPINC1, F5
4venous thrombosis30.7SERPINC1, F3, PROS1, F5
5thrombocytopenia30.6F5, F3, SERPINC1
6antiphospholipid syndrome30.5SERPINC1, F3, PROS1, F5
7thromboembolism30.3SERPINC1, F3, F5
8n syndrome10.7
9head injury10.6
10headache10.6
11ulcerative colitis10.5
12acute leukemia10.5
13systemic lupus erythematosus10.4
14cortical blindness10.4
15thyrotoxicosis10.4
16heparin-induced thrombocytopenia10.4
17protein r deficiency10.4
18blindness10.4
19deficiency anemia10.2
20moyamoya disease10.2
21crohn's disease10.2
22evans' syndrome10.2
23pseudotumor cerebri10.2
24cellulitis10.2
25wegener's granulomatosis10.2
26intracranial hypotension10.2
27hemoglobinuria10.2
28bone lymphoma10.2
29iron deficiency anemia10.2
30acquired immunodeficiency syndrome10.2
31burkitt's lymphoma10.2
32trichinosis10.2
33adult syndrome10.2
34typhoid fever10.2
35behcet's disease10.2
36down syndrome10.2
37adenocarcinoma10.2
38aplastic anemia10.2
39tuberculosis10.2
40aplasia cutis congenita10.2
41lymphoblastic lymphoma10.2
42macrocephaly-capillary malformation10.2
43paroxysmal nocturnal hemoglobinuria10.2
44pediatric hypertension10.2
45sinus cancer10.2
46steroid-resistant nephrotic syndrome10.2
47hereditary antithrombin deficiency10.2
48postural hypotension10.2
49sinusitis10.2
50intravascular large b-cell lymphoma10.2

Graphical network of the top 20 diseases related to Sagittal Sinus Thrombosis:



Diseases related to sagittal sinus thrombosis

Clinical Features for Sagittal Sinus Thrombosis

Drugs & Therapeutics for Sagittal Sinus Thrombosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sagittal Sinus Thrombosis

Drug clinical trials:

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Search CenterWatch for Sagittal Sinus Thrombosis

Genetic Tests for Sagittal Sinus Thrombosis

Anatomical Context for Sagittal Sinus Thrombosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Sagittal Sinus Thrombosis:

33
Brain, Bone marrow, Myeloid, T cells, B lymphoblasts, B cells

Animal Models for Sagittal Sinus Thrombosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sagittal Sinus Thrombosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.7F3
2MP:00053807.8SERPINC1, F3, PROS1, F5

Publications for Sagittal Sinus Thrombosis

Sources:
51PubMed
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Articles related to Sagittal Sinus Thrombosis:

(show top 50)    (show all 191)
idTitleAuthorsYear
1
Post-traumatic sagittal sinus thrombosis: case report. (23588984)
2013
2
Acute presentation of sagittal sinus thrombosis following closed head injury without overlying fracture. (23307334)
2013
3
Sagittal sinus thrombosis while on tamoxifen requiring craniectomy. (22720357)
2012
4
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: superior sagittal sinus thrombosis. (21463850)
2011
5
Cortical blindness due to sagittal sinus thrombosis in acute lymphoblastic leukaemia. (19006563)
2009
6
Superior sagittal sinus thrombosis presenting as a continuous headache: a case report and review of the literature. (20062608)
2009
7
Anesthesia for cesarean delivery in the term pregnant following acute onset severe intracranial superior sagittal sinus thrombosis. (19961118)
2009
8
Chronic superior sagittal sinus thrombosis with phlebosclerotic changes of the subarachnoid and intracerebral veins. (16961069)
2006
9
Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen. (15989707)
2005
10
Hydrocephalus due to superior sagittal sinus thrombosis. (15666188)
2005
11
Post gravidic superior sagittal sinus thrombosis with elevated levels of homocystinemia. (15702064)
2004
12
Sagittal sinus thrombosis in a teenager: homocystinuria associated with reversible antithrombin deficiency. (12162390)
2002
13
Diffusion-weighted magnetic resonance imaging in superior sagittal sinus thrombosis. (12116746)
2002
14
Late puerperal sagittal sinus thrombosis associated with primary antiphospholipid antibody syndrome. (12554264)
2002
15
Postpartum postural headache due to superior sagittal sinus thrombosis mistaken for spontaneous intracranial hypotension. (11305834)
2001
16
Ulcerative colitis with sagittal sinus thrombosis with normal coagulation profile. (10812827)
2000
17
Superior sagittal sinus thrombosis secondary to hyperthyroidism. (17895204)
2000
18
Superior sagittal sinus and cerebral cortical venous thrombosis caused by congenital protein C deficiency--case report. (11153197)
2000
19
Superior sagittal sinus thrombosis and transient ischemic attacks: possible mechanism. (9811193)
1998
20
Superior sagittal sinus thrombosis: a clinical and experimental study. (17171061)
1998
21
Superior sagittal sinus thrombosis in a patient heterozygous for the novel 20210 A allele of the prothrombin gene. (9459354)
1998
22
Radiological case of the month. Sagittal sinus thrombosis in hypernatremic dehydration. (9811296)
1998
23
Urokinase treatment of sagittal sinus thrombosis with venous hemorrhagic infarction. (17895121)
1998
24
Direct thrombolysis of superior sagittal sinus thrombosis with coexisting intracranial hemorrhage. (9282848)
1997
25
Superior sagittal sinus thrombosis in a child with nephrotic syndrome. (8703714)
1996
26
Superior sagittal sinus thrombosis and acquired free protein S deficiency in the elderly. (8571436)
1996
27
Neuroradiology case of the day. Sagittal sinus thrombosis with hemorrhagic venous infarct. (8659396)
1996
28
Homocystinuria presenting with sagittal sinus thrombosis in infancy. (8745393)
1996
29
Nonmetastatic superior sagittal sinus thrombosis complicating Burkitt's lymphoma: a case report. (7607873)
1995
30
Superior sagittal sinus thrombosis in the presence of idiopathic bilateral internal jugular vein stenosis. (8136582)
1994
31
Superior sagittal sinus thrombosis after radical neck dissection. (17170925)
1994
32
Fatal superior sagittal sinus thrombosis associated with internal jugular vein catheterization. (8267072)
1993
33
Case report: treatment of superior sagittal sinus thrombosis with urokinase. (1458880)
1992
34
Superior sagittal sinus thrombosis--an unexpected cause of papilloedema. (1295530)
1992
35
CSF hydrodynamics in superior sagittal sinus thrombosis. (1583513)
1992
36
Superior sagittal sinus thrombosis after internal jugular vein cannulation. (1931408)
1991
37
Cerebral venous and sagittal sinus thrombosis after transcallosal removal of a colloid cyst of the third ventricle: case report. (2320225)
1990
38
Direct thrombolytic therapy for superior sagittal sinus thrombosis. (2505559)
1989
39
A case of thrombosed aneurysm of the vein of Galen associated with superior sagittal sinus thrombosis. (2634086)
1989
40
Postoperative sagittal sinus thrombosis after spinal anesthesia. (3963444)
1986
41
Demonstration of superior sagittal sinus thrombosis by indium-111 platelet scintigraphy. (3753267)
1986
42
Superior sagittal sinus thrombosis associated with Evans' syndrome of haemolytic anaemia. (4056835)
1985
43
Superior sagittal sinus thrombosis after closed head injury. (3892357)
1985
44
Sagittal sinus thrombosis and occult malignancy. (6842227)
1983
45
Trichinosis associated with superior sagittal sinus thrombosis. (7073258)
1982
46
Sagittal sinus thrombosis in early pregnancy. (7088432)
1982
47
Puerperal superior sagittal sinus thrombosis. (7162448)
1982
48
Computer tomography in superior sagittal sinus thrombosis. (7435218)
1980
49
Superior Sagittal Sinus Thrombosis. (831684)
1977
50
Septic superior sagittal sinus thrombosis after oral surgery. (4513469)
1973

Genetic Variations for Sagittal Sinus Thrombosis

Expression for genes affiliated with Sagittal Sinus Thrombosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sagittal Sinus Thrombosis

Search GEO for disease gene expression data for Sagittal Sinus Thrombosis.

Pathways for genes affiliated with Sagittal Sinus Thrombosis

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
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Compounds for genes affiliated with Sagittal Sinus Thrombosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1heparin45 29 11 2413.2PROS1
2hirugen459.8SERPINC1, F5
3nafamostat mesilate459.8F5, SERPINC1
4ancrod459.8F5, SERPINC1
5eltrombopag50 1110.8SERPINC1, F5
6coumarins459.7F3
7celite459.6F3, SERPINC1
8certoparin459.6F3, SERPINC1
9reviparin459.6F3, SERPINC1
10dabigatran459.6F3, SERPINC1
11efegatran459.6SERPINC1, F3
12nadroparin45 1110.5SERPINC1, F3
13polybrene459.5SERPINC1, F3
14hepaplastin459.5F3, SERPINC1
15organon459.4F3, SERPINC1
16tinzaparin45 1110.4F3, SERPINC1
17Drotrecogin alfa119.4F5, PROS1
18rivaroxaban45 1110.4F3, SERPINC1
19kaolin459.4F3, F5
20vitamin k145 2410.3F3, SERPINC1
21acenocoumarol45 50 1111.1F5, F3
22inogatran459.1F5, F3, SERPINC1
23ecarin459.1SERPINC1, F3, F5
24spectrozyme459.1SERPINC1, F3, F5
25danaparoid459.1F5, F3, SERPINC1
26ximelagatran45 1110.1SERPINC1, F3, F5
27heparinoids459.1SERPINC1, F3, F5
28fondaparinux459.1F5, F3, SERPINC1
29bivalirudin45 1110.1SERPINC1, F3, F5
30argatroban45 1110.1SERPINC1, F3, F5
31protamine sulfate459.1F5, F3, SERPINC1
32ristocetin459.1SERPINC1, F3, F5
33levonorgestrel45 60 29 1112.1SERPINC1, F3, F5
34coumarin45 2 50 2412.1F5, F3, SERPINC1
35desmopressin45 60 29 1112.1F5, F3, SERPINC1
36fluorescein45 1110.1F5, F3, SERPINC1
37hirudin459.1SERPINC1, F3, F5
38protamine459.1SERPINC1, F3, F5
39dermatan sulfate459.1SERPINC1, F3, F5
40dextran sulfate459.1F5, F3, SERPINC1
41warfarin45 50 11 2412.1SERPINC1, F3, F5
42kininogen459.0SERPINC1, F3, F5
43aprotinin45 1110.0F5, F3, SERPINC1
44homocysteine45 2410.0SERPINC1, F3, F5
45gamma-carboxyglutamic acid458.9F5, PROS1, F3
46hydroxyethyl starch458.9SERPINC1, F3
47citrate458.8SERPINC1, F3, F5
48creatinine458.4SERPINC1, F3, PROS1, F5
49prostacyclin458.0ASRGL1, SERPINC1, F3, PROS1, F5
50vegf458.0SERPINC1, F3, PROS1, F5

GO Terms for genes affiliated with Sagittal Sinus Thrombosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3PROS1, F5

Biological processes related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.3PROS1, F5
2negative regulation of endopeptidase activityGO:0109519.1SERPINC1, PROS1
3blood coagulationGO:0075968.0SERPINC1, F3, PROS1, F5

Molecular functions related to Sagittal Sinus Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2SERPINC1, F3

Products for genes affiliated with Sagittal Sinus Thrombosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sagittal Sinus Thrombosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet