MCID: SLV012
MIFTS: 42

Salivary Gland Adenoid Cystic Carcinoma malady

Rare diseases, Skin diseases, Endocrine diseases, Cancer diseases categories

Summaries for Salivary Gland Adenoid Cystic Carcinoma

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NIH Rare Diseases:41 Adenoid cystic carcinoma (acc) is a rare form of adenocarcinoma, which is cancer that begins in gladular tissues. acc most commonly arises in the head and neck, in various parts of the major and minor salivary glands including the palate, nasopharynx, lining of the mouth, voice box (larynx) or windpipe (trachea). it can also occur in the breast, uterus, or other locations in the body. early symptoms depend on the tumor's location and may include lumps under the lining of the mouth or facial skin; numbness in the mouth or face; difficulty swallowing; hoarseness; pain; or paralysis of a facial nerve. acc often has long periods with no growth followed by growth spurts; however, it can be aggressive in some people. acc spreads along nerves or through the bloodstream, and only spreads to the lymph nodes in about 5-10% of cases. the cause of acc is currently unknown. treatment depends on many factors and may include surgery, radiation, and/or chemotherapy. last updated: 12/10/2014

MalaCards based summary: Salivary Gland Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma, is related to adenoma and melanoma. An important gene associated with Salivary Gland Adenoid Cystic Carcinoma is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are Notch Signaling Pathways and Leishmaniasis. The compounds retinoid and agarose have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lymph node and breast, and related mouse phenotypes are hearing/vestibular/ear and digestive/alimentary.

Disease Ontology:9 A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. these structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

Aliases & Classifications for Salivary Gland Adenoid Cystic Carcinoma

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Salivary Gland Adenoid Cystic Carcinoma, Aliases & Descriptions:

Name: Salivary Gland Adenoid Cystic Carcinoma 9 43
Adenoid Cystic Carcinoma 9 41 11 60
Cylindroma 9 41
Adenoid Cystic Carcinoma of Salivary Gland 60
Eccrine Dermal Cylindroma 60
Carcinoma Adenoid Cystic 43
 
Adenoid Cystic Cancer 9
Adenocystic Carcinoma 41
Carcinoma, Cribriform 60
Cribriform Carcinoma 41
Cylindroma Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases, Endocrine diseases


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Disease Ontology9 DOID:4866
NCIt38 C2970
MeSH33 D003528

Related Diseases for Salivary Gland Adenoid Cystic Carcinoma

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Diseases related to Salivary Gland Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.2ITGA6, RUNX3, BCL2
2melanoma30.3EZH2, ITGA6, BCL2
3adenocarcinoma30.2ITGA6, BCL2, AQP1, RUNX3
4adenoiditis11.3
5cribriform carcinoma10.9
6pleomorphic adenoma10.8
7lacrimal gland adenoid cystic carcinoma10.8
8laryngeal adenoid cystic carcinoma10.7
9cervical adenoid cystic carcinoma10.7
10maxillary sinus adenoid cystic carcinoma10.6
11mucoepidermoid carcinoma10.6
12trachea adenoid cystic carcinoma10.6
13esophageal adenoid cystic carcinoma10.6
14bartholin's gland adenoid cystic carcinoma10.6
15breast adenoid cystic carcinoma10.6
16laryngitis10.6
17endotheliitis10.6
18cylindromatosis, familial10.6
19ethmoid sinus adenoid cystic carcinoma10.6
20lung adenoid cystic carcinoma10.6
21prostate adenoid cystic carcinoma10.6
22parotid gland adenoid cystic carcinoma10.5
23thyroiditis10.5
24adenoid cystic carcinoma of the corpus uteri10.5
25sublingual gland adenoid cystic carcinoma10.4
26adenoid basal cell carcinoma10.4
27nasopharyngitis10.4
28basal cell carcinoma10.4
29paranasal sinus cancer10.4
30choroiditis10.4
31cervicitis10.4
32polymorphous low-grade adenocarcinoma10.4
33poncet-spiegler's cylindroma10.4
34renal cell carcinoma10.4
35hepatitis10.4
36sinusitis10.4
37oral squamous cell carcinoma10.4
38basaloid squamous cell carcinoma10.4
39spiradenoma10.4
40epithelial-myoepithelial carcinoma10.4
41cerebritis10.4
42small cell carcinoma10.4
43hypoxia10.4
44adnexal spiradenoma/cylindroma of a sweat gland10.3
45prostatitis10.3
46myeloid leukemia10.3BCL2
47asthma10.2
48brooke-spiegler syndrome10.2
49myoepithelioma10.2
50mucosal melanoma10.2

Graphical network of the top 20 diseases related to Salivary Gland Adenoid Cystic Carcinoma:



Diseases related to salivary gland adenoid cystic carcinoma

Symptoms for Salivary Gland Adenoid Cystic Carcinoma

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Drugs & Therapeutics for Salivary Gland Adenoid Cystic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Salivary Gland Adenoid Cystic Carcinoma

Search NIH Clinical Center for Salivary Gland Adenoid Cystic Carcinoma

Genetic Tests for Salivary Gland Adenoid Cystic Carcinoma

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Anatomical Context for Salivary Gland Adenoid Cystic Carcinoma

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MalaCards organs/tissues related to Salivary Gland Adenoid Cystic Carcinoma:

31
Salivary gland, Lymph node, Breast, Skin, Uterus, Trachea, Endothelial

Animal Models for Salivary Gland Adenoid Cystic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Salivary Gland Adenoid Cystic Carcinoma:

35 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1AQP1, ITGA6, BCL2
2MP:00053818.9RUNX3, ITGA6, BCL2
3MP:00053678.9BCL2, ITGA6, AQP1
4MP:00020068.8EZH2, ITGA6, BCL2
5MP:00053698.7BCL2, EZH2, RUNX3
6MP:00053888.6RUNX3, AQP1, ITGA6, BCL2
7MP:00053798.6BCL2, ITGA6, AQP1, RUNX3
8MP:00053918.6BCL2, ITGA6, AQP1
9MP:00107718.4BCL2, ITGA6, EZH2, RUNX3
10MP:00053878.3BCL2, ITGA6, EZH2, RUNX3
11MP:00053858.3BCL2, ITGA6, AQP1, EZH2
12MP:00053868.2RUNX3, EZH2, AQP1, BCL2
13MP:00053848.2RUNX3, EZH2, ITGA6, BCL2
14MP:00053977.8BCL2, ITGA6, AQP1, EZH2, RUNX3
15MP:00036317.8RUNX3, EZH2, AQP1, ITGA6, BCL2
16MP:00053787.8BCL2, ITGA6, AQP1, EZH2, RUNX3
17MP:00107687.8RUNX3, EZH2, AQP1, ITGA6, BCL2

Publications for Salivary Gland Adenoid Cystic Carcinoma

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Articles related to Salivary Gland Adenoid Cystic Carcinoma:

(show all 42)
idTitleAuthorsYear
1
Inhibition of mTOR reduce Stat3 and PAI related angiogenesis in salivary gland adenoid cystic carcinoma. (25520866)
2014
2
Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma. (25551195)
2014
3
Differential expression of vascular endothelial growth factor in high- and low-metastasis cell lines of salivary gland adenoid cystic carcinoma. (24510998)
2014
4
A study on the inhibition of VEGF expression in salivary gland adenoid cystic carcinoma cells via iNOS gene RNAi in vitro. (25065562)
2014
5
High expression of SOX2 is associated with poor prognosis in patients with salivary gland adenoid cystic carcinoma. (24828201)
2014
6
19-year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma. (24170702)
2013
7
Expression of podoplanin in salivary gland adenoid cystic carcinoma and its association with distant metastasis and clinical outcomes. (22580922)
2012
8
Developmental transcription factor EN1--a novel biomarker in human salivary gland adenoid cystic carcinoma. (21800291)
2012
9
Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases. (22647764)
2012
10
High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma. (22712799)
2012
11
Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. (21551254)
2011
12
Critical regions and spreading of runt-related transcription factor-3 C-phosphate-G (CpG) island methylation in human salivary gland adenoid cystic carcinoma. (21658745)
2011
13
Metastatic pleural effusion: a rare presentation of salivary gland adenoid cystic carcinoma. (21545072)
2011
14
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. (21692051)
2011
15
Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. (21567090)
2011
16
Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway. (21279332)
2011
17
Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma. (21550270)
2011
18
RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M]. (21223819)
2010
19
Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma]. (21223798)
2010
20
Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. (19589718)
2009
21
Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma]. (19575999)
2009
22
Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. (18844240)
2009
23
Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. (19688981)
2009
24
Survival from salivary glands adenoid cystic carcinoma in European populations. (19095489)
2009
25
NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. (19317804)
2009
26
High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. (18326020)
2008
27
Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. (18254353)
2008
28
Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases. (18347813)
2008
29
Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma. (18657296)
2008
30
Fine-needle aspiration biopsy as an auxiliary diagnostic tool on intraoral minor salivary gland adenoid cystic carcinoma. (18644520)
2008
31
DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. (17545515)
2007
32
In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma. (17543095)
2007
33
SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway. (17591960)
2007
34
Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. (17113340)
2007
35
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. (17520682)
2007
36
Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. (16757203)
2006
37
Laminin-1 and SIKVAV a laminin-1-derived peptide, regulate the morphology and protease activity of a human salivary gland adenoid cystic carcinoma cell line. (15006619)
2004
38
Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma. (15028021)
2004
39
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma. (15292943)
2004
40
C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. (12118104)
2002
41
Apoptosis-induced and -suppressed cells in salivary gland adenoid cystic carcinoma: correlation with histological growth patterns. (10522207)
1999
42
Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma. (8521108)
1995

Variations for Salivary Gland Adenoid Cystic Carcinoma

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Cosmic variations for Salivary Gland Adenoid Cystic Carcinoma:

7 (show all 67)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110905TP53salivary gland,NS,carcinoma,adenoid cystic carcinoma4
210648TP53salivary gland,NS,carcinoma,adenocarcinoma3
343828TP53salivary gland,major,carcinoma,adenoid cystic carcinoma3
444035TP53salivary gland,major,carcinoma,adenoid cystic carcinoma3
510817TP53salivary gland,major,carcinoma,adenoid cystic carcinoma3
643878TP53salivary gland,major,carcinoma,adenoid cystic carcinoma3
7763PIK3CAsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
812591PIK3CAsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
9757PIK3CAsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
10754PIK3CAsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
11481HRASsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
12498HRASsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
13486HRASsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
14496HRASsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
1588749CREBBPsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
161644509CREBBPsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
171644511CREBBPsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
181577253PTENsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
195070PTENsalivary gland,NS,carcinoma,adenocarcinoma3
205132PTENsalivary gland,NS,carcinoma,adenocarcinoma3
211645004SMARCA2salivary gland,NS,carcinoma,adenoid cystic carcinoma4
221645006SMARCA2salivary gland,NS,carcinoma,adenoid cystic carcinoma4
23561NRASsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
24569NRASsalivary gland,NS,carcinoma,adenocarcinoma3
25467BRAFsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
2651383BRAFsalivary gland,mouth floor,carcinoma,adenoid cystic carcinoma3
271644949RIT1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
281644950RIT1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
291644432BRCA1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
301644434BRCA1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
3122965FBXW7salivary gland,NS,carcinoma,adenoid cystic carcinoma4
3228746IDH1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
331644700KDM6Asalivary gland,NS,carcinoma,adenoid cystic carcinoma4
341644611FIGFsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
3513168CTNNB1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
36143827AXIN1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
3721323ATMsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
38143850APCsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
391644362ACVR1Bsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
401644393ANKRD17salivary gland,NS,carcinoma,adenoid cystic carcinoma4
411644438BTAF1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
421644441BUB1Bsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
431644539DDX42salivary gland,NS,carcinoma,adenoid cystic carcinoma4
441658925DIRAS3salivary gland,NS,carcinoma,adenoid cystic carcinoma4
4551381KITsalivary gland,face,carcinoma,adenoid cystic carcinoma3
461658935CHEK2salivary gland,mouth floor,carcinoma,adenoid cystic carcinoma3
471644472CAMK4salivary gland,NS,carcinoma,adenoid cystic carcinoma4
481644565EGFsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
491658963MAP3K9salivary gland,NS,carcinoma,adenoid cystic carcinoma4
501645068TNPO2salivary gland,NS,carcinoma,adenoid cystic carcinoma4
511658909TFAP2Dsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
521645052TFAP2Asalivary gland,NS,carcinoma,adenoid cystic carcinoma4
531659031TRPV5salivary gland,mouth floor,carcinoma,adenoid cystic carcinoma3
541645040TANC1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
551645001SLC9A7salivary gland,NS,carcinoma,adenoid cystic carcinoma4
561644828NPC1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
571645110USP1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
581644758MAGI2salivary gland,NS,carcinoma,adenoid cystic carcinoma4
591644734LHFPL4salivary gland,NS,carcinoma,adenoid cystic carcinoma4
601644738LIX1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
611644892PIK3CGsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
621644911PRKCIsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
631644939RB1salivary gland,NS,carcinoma,adenoid cystic carcinoma4
641644936RAP1Bsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
651644934RALAsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
661644929RAB40Bsalivary gland,NS,carcinoma,adenoid cystic carcinoma4
6751382KRASsalivary gland,mouth floor,carcinoma,adenoid cystic carcinoma3

Expression for genes affiliated with Salivary Gland Adenoid Cystic Carcinoma

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Search GEO for disease gene expression data for Salivary Gland Adenoid Cystic Carcinoma.

Pathways for genes affiliated with Salivary Gland Adenoid Cystic Carcinoma

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Pathways related to Salivary Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5RUNX3, BCL2
2
Show member pathways
9.5BCL2, ITGA6
39.5BCL2, ITGA6
49.5BCL2, ITGA6
59.2BCL2, EZH2

Compounds for genes affiliated with Salivary Gland Adenoid Cystic Carcinoma

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Sources:
43Novoseek, 24HMDB
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Compounds related to Salivary Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1retinoid439.5BCL2, ITGA6
2agarose439.2BCL2, ITGA6
3oligonucleotide438.4RUNX3, AQP1, ITGA6, BCL2
4retinoic acid43 249.1RUNX3, EZH2, ITGA6, BCL2
5vegf437.6BCL2, ITGA6, AQP1, EZH2, RUNX3

GO Terms for genes affiliated with Salivary Gland Adenoid Cystic Carcinoma

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Cellular components related to Salivary Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear membraneGO:00319659.4BCL2, AQP1
2basal plasma membraneGO:00099259.0ITGA6, AQP1

Biological processes related to Salivary Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adhesionGO:00163379.5BCL2, ITGA6
2hair follicle morphogenesisGO:00310699.4BCL2, RUNX3
3negative regulation of G1/S transition of mitotic cell cycleGO:020001349.2BCL2, EZH2
4cellular response to hypoxiaGO:00714569.1BCL2, AQP1

Molecular functions related to Salivary Gland Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.5BCL2, ITGA6, AQP1, EZH2, RUNX3

Products for genes affiliated with Salivary Gland Adenoid Cystic Carcinoma

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Sources for Salivary Gland Adenoid Cystic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet