MCID: SLV002
MIFTS: 52

Salivary Gland Cancer malady

Endocrine diseases, Cancer diseases, Oral diseases, Rare diseases categories

Summaries for Salivary Gland Cancer

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MedlinePlus:34 Your salivary glands make saliva - sometimes called spit - and empty it into your mouth through openings called ducts. saliva makes your food moist, which helps you chew and swallow. it helps you digest your food. it also cleans your mouth and contains antibodies that can kill germs. salivary gland cancer is a type of head and neck cancer. it is rare. it may not cause any symptoms, or you could notice a lump in your ear, cheek, jaw, lip, or inside the mouth fluid draining from your ear trouble swallowing or opening the mouth widely numbness, weakness, or pain in your face doctors diagnose salivary gland cancer using a physical exam, imaging tests, and a biopsy. treatment can include surgery, radiation therapy, and/or chemotherapy. nih: national cancer institute

MalaCards based summary: Salivary Gland Cancer, also known as malignant tumor of the major salivary gland, is related to breast cancer and adenocarcinoma. An important gene associated with Salivary Gland Cancer is MET (met proto-oncogene), and among its related pathways are FGF signaling pathway and Renal cell carcinoma. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and testes, and related mouse phenotypes are tumorigenesis and embryogenesis.

Disease Ontology:10 An oral cavity cancer that is located in the salivary gland.

Wikipedia:65 Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are... more...

Aliases & Classifications for Salivary Gland Cancer

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Salivary Gland Cancer, Aliases & Descriptions:

Name: Salivary Gland Cancer 10 12 45 34
Malignant Tumor of the Major Salivary Gland 10 62
Malignant Neoplasm of Major Salivary Gland 10 62
Malignant Tumor of the Salivary Gland 10 62
 
Malignant Neoplasm of Salivary Gland 10 62
Salivary Gland Carcinoma 10 62
Malignant Neoplasm of Salivary Gland Duct 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Endocrine diseases, Oral diseases


External Ids:

Disease Ontology10 DOID:8850, DOID:0050904
ICD9CM29 142.8
SNOMED-CT57 187648003
MeSH35 D012468

Related Diseases for Salivary Gland Cancer

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Diseases in the Salivary Gland Cancer family:

Salivary Gland Cancer, Adult

Diseases related to Salivary Gland Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.5MET, HGF, SERPINB5, MMP13
2adenocarcinoma30.4SERPINB5, MMP13, MET, HGF
3adenoma30.2MET, SERPINB5, PPARG
4endotheliitis10.4
5brooke-spiegler syndrome10.3
6hidradenoma10.3
7myoepithelioma10.3
8polymorphous low-grade adenocarcinoma10.3
9salivary gland cancer, adult10.3
10salivary gland cancer, childhood10.3
11pleomorphic adenoma10.2
12vaccinia10.2
13salivary gland adenoid cystic carcinoma10.2
14acne10.2
15pharyngitis10.2
16mucoepidermoid carcinoma10.2
17adenoiditis10.2
18brain cancer10.2
19cervicitis10.2
20parotid gland cancer10.2
21sublingual gland cancer10.2
22thyroiditis10.2
23oral cancer10.2
24hypoxia10.2
25benign epithelial tumor of the salivary glands10.2
26malignant epithelial tumor of the salivary glands10.2
27vitreoretinopathy, neovascular inflammatory10.0MET, HGF
28thyroid carcinoma, papillary10.0MET, PPARG
29malignant peripheral nerve sheath tumor10.0MMP13, MET
30microvascular complications of diabetes 110.0MET, HGF
31neurofibroma10.0MET, MMP13
32thyroid cancer, anaplastic10.0MET, PPARG
33kidney cancer10.0MET, HGF
34mesothelioma, somatic10.0HGF, MET
35arteriosclerosis10.0HGF, PPARG
36hepatoblastoma10.0HGF, MET
37mesothelioma10.0HGF, MET
38cholangiocarcinoma10.0HGF, MET
39lung benign neoplasm10.0MET, HGF
40sarcoma, synovial10.0MMP13, HGF, MET
41squamous cell carcinoma, head and neck10.0MET, MMP13, HGF
42chondrosarcoma10.0MMP13, MET
43lung cancer10.0MET, HGF, PPARG
44bone cancer10.0SERPINB5, MMP13
45pulmonary fibrosis10.0HGF, PPARG, MMP13
46glioblastoma10.0HGF, MET, PPARG
47pancreatic cancer10.0MET, HGF, SERPINB5
48stomach cancer10.0MET, HGF, SERPINB5
49thyroid cancer10.0MET, SERPINB5, PPARG
50ovarian cancer, somatic10.0SERPINB5, MET, HGF

Graphical network of the top 20 diseases related to Salivary Gland Cancer:



Diseases related to salivary gland cancer

Symptoms for Salivary Gland Cancer

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Drugs & Therapeutics for Salivary Gland Cancer

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Drug clinical trials:

Search ClinicalTrials for Salivary Gland Cancer

Search NIH Clinical Center for Salivary Gland Cancer

Genetic Tests for Salivary Gland Cancer

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Anatomical Context for Salivary Gland Cancer

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MalaCards organs/tissues related to Salivary Gland Cancer:

33
Salivary gland, Testes, Lymph node, Breast, Brain, Liver, Thyroid, Skin, Testis

FMA organs/tissues related to Salivary Gland Cancer:

16
The salivary gl

Animal Models for Salivary Gland Cancer or affiliated genes

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MGI Mouse Phenotypes related to Salivary Gland Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9CD151, MET, PPARG
2MP:00053808.2HGF, MET, SERPINB5, PPARG
3MP:00053858.0PPARG, MMP13, MET, HGF, CD151
4MP:00053787.9PPARG, MMP13, MET, HGF, CD151
5MP:00107687.3PPARG, SERPINB5, MET, HGF, CD151
6MP:00053847.2CD151, HGF, MET, MMP13, SERPINB5, PPARG

Publications for Salivary Gland Cancer

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Articles related to Salivary Gland Cancer:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Increased risk of salivary gland cancer among women with a previous cancer diagnosis. (25581457)
2015
2
Salivary Gland Cancer in BRCA-Positive Families : A Retrospective Review. (25257187)
2014
3
The Impact of Demographic and Socioeconomic Factors on Major Salivary Gland Cancer Survival. (24647644)
2014
4
Retracted: the oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac. (25610927)
2014
5
Overview of major salivary gland cancer surgery in Ontario (2003A?2010). (25492404)
2014
6
Risk of salivary gland cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. (22836059)
2013
7
Salivary gland cancer stem cells. (23810400)
2013
8
Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer. (23242174)
2013
9
The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. (23608756)
2013
10
Expression and function of CXCR4 in human salivary gland cancers. (22847686)
2013
11
Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells. (23517130)
2013
12
Predictors of cervical lymph node metastasis in salivary gland cancer. (23780687)
2013
13
Predictive index for lymph node management of major salivary gland cancer. (22539053)
2012
14
Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices. (22499505)
2012
15
The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation. (22445095)
2012
16
Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers. (21717524)
2012
17
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. (22240798)
2012
18
Matrix metalloproteinase (MMP)-7 in salivary gland cancer. (19929564)
2010
19
A prognostic index for predicting lymph node metastasis in minor salivary gland cancer. (19386433)
2010
20
Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease. (20191625)
2010
21
Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. (21083600)
2010
22
Base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy. (20070763)
2009
23
Childbearing and salivary gland cancer: a population-based nested case-control study. (19680040)
2009
24
Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. (18355439)
2008
25
Immunohistochemical expression of androgen receptor in salivary gland cancers. (19391487)
2008
26
Late recurrence from salivary gland cancer: when does "cure" mean cure? (18008358)
2008
27
Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. (16652146)
2006
28
Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. (16469527)
2006
29
Salivary gland cancer in Finland 1991--96: an evaluation of 237 cases. (15880955)
2005
30
CD151 forms a functional complex with c-Met in human salivary gland cancer cells. (16139245)
2005
31
Herceptin plus chemotherapy in relapsed and/or metastatic salivary gland cancer. (15598592)
2005
32
TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer. (15379637)
2004
33
An update on the systemic therapy of malignant salivary gland cancers: role of chemotherapy and molecular targeted agents. (15579019)
2004
34
Occupational exposures and salivary gland cancer mortality among African American and white workers in the United States. (15091292)
2004
35
High incidence of lymph node metastasis in major salivary gland cancer. (12874071)
2003
36
Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. (11944908)
2002
37
Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines. (11836575)
2002
38
Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line. (12434298)
2002
39
Nodal metastasis in major salivary gland cancer: predictive factors and effects on survival. (12162768)
2002
40
Predictors of nodal metastasis in salivary gland cancer. (12210032)
2002
41
Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. (11836610)
2002
42
Prognostic factors in major salivary gland cancer. (11568581)
2001
43
Menstrual and reproductive factors for salivary gland cancer risk in women. (10468426)
1999
44
Salivary gland cancer in the United States. (10613342)
1999
45
A case/control study of risk factors for major salivary gland cancer. (9482552)
1998
46
Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell. (9459148)
1998
47
Diet and the risk of salivary gland cancer. (9230779)
1997
48
Salivary gland cancer in Alaskan natives, 1966-1980. (2820863)
1987
49
The association between salivary gland cancer and breast cancer. (5394367)
1969
50
Salivary gland cancer and breast cancer. (5695011)
1968

Variations for Salivary Gland Cancer

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Cosmic variations for Salivary Gland Cancer:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
145604TP53salivary gland,major,carcinoma,mucoepidermoid carcinoma1

Expression for genes affiliated with Salivary Gland Cancer

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Search GEO for disease gene expression data for Salivary Gland Cancer.

Pathways for genes affiliated with Salivary Gland Cancer

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Pathways related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MET, HGF
29.6MET, HGF
39.6HGF, MET
49.6HGF, MET
59.6HGF, MET
69.6MET, HGF
79.6HGF, MET
89.6HGF, MET
99.6MET, HGF
109.5MET, PPARG
11
Show member pathways
9.4CD151, MET
12
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.4PPARG, MMP13
13
Show member pathways
9.3CD151, MMP13
149.1HGF, MET, PPARG
15
Show member pathways
9.1PPARG, MET, HGF
16
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1MET, PPARG, HGF
17
Show member pathways
9.1MMP13, MET, HGF
188.8MET, HGF, SERPINB5

Compounds for genes affiliated with Salivary Gland Cancer

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Compounds related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6110.0MET, HGF
2su 112746110.0MET, HGF
3pha 6657526110.0MET, HGF
4crizotinib61 5111.0HGF, MET
5k252a4510.0MET, HGF
6ag 1478459.9HGF, MET
72-cyano-3,12-dioxoolean-1,9-dien-28-oic acid459.9MMP13, PPARG
8gefitinib45 51 1311.9HGF, MET
9alginate459.8MMP13, HGF
10l-nmma459.8HGF, PPARG
11hydroxyproline45 26 1311.8MMP13, HGF
12ndga459.8MMP13, PPARG
13geldanamycin45 51 61 1312.8HGF, MET
14losartan45 51 30 1312.8PPARG, HGF
15aprotinin45 1310.7HGF, MMP13
16phenobarbital45 30 51 1312.7HGF, PPARG
17suramin45 30 1311.7HGF, MET
18carnitine459.7PPARG, HGF
19ccl445 3010.5MMP13, MET, HGF
20sp 60012545 6110.5MMP13, HGF
21herbimycin a45 6110.5MMP13, MET, HGF
2212-o-tetradecanoylphorbol 13-acetate459.5MMP13, MET, HGF
23vitamin d459.5HGF, MET, PPARG
24pd 98,059459.5HGF, MET, MMP13
25ly294002459.5HGF, MET, PPARG
26glycosaminoglycan459.4MET, MMP13
27actinomycin d459.4HGF, MET, MMP13
28thymidine45 2610.4MMP13, MET, HGF
29heparin45 30 26 1312.4MMP13, MET, HGF
30retinoid459.4PPARG, MMP13, HGF
31indomethacin45 30 61 1312.4HGF, MMP13, PPARG
32sb 20358045 6110.4HGF, MMP13, PPARG
33ornithine45 2610.3HGF, MET
34p002459.1SERPINB5, MMP13, MET
35cisplatin45 51 61 1312.1HGF, MET, SERPINB5
36dexamethasone45 51 30 1312.1HGF, MMP13, PPARG
37phosphatidylinositol459.1HGF, MET, MMP13
38aspirin45 51 30 2612.1HGF, SERPINB5, PPARG
39genistein45 30 61 3 26 1314.0PPARG, MMP13, MET, HGF
40pge2459.0HGF, MET, MMP13, PPARG
41cycloheximide459.0HGF, MET, MMP13, PPARG
42retinoic acid45 2610.0HGF, MET, MMP13, PPARG
43pdtc458.7PPARG, SERPINB5, MET, HGF
44paraffin458.7HGF, MET, MMP13, SERPINB5
45testosterone45 61 26 1311.7HGF, MET, SERPINB5, PPARG
46lipid458.6PPARG, SERPINB5, MET, HGF
47serine458.6HGF, MET, MMP13, SERPINB5
48vegf458.2PPARG, SERPINB5, MMP13, MET, HGF
49estrogen458.2HGF, MET, MMP13, SERPINB5, PPARG
50matrigel458.1CD151, HGF, MET, MMP13, SERPINB5

GO Terms for genes affiliated with Salivary Gland Cancer

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Biological processes related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:019012999.8HGF, MET
2myoblast proliferationGO:00514509.8HGF, MET
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:00606659.8HGF, MET
4placenta developmentGO:00018909.7MET, PPARG
5liver developmentGO:00018899.6HGF, MET
6organ regenerationGO:00311009.6PPARG, HGF
7glucose homeostasisGO:00425939.4MET, PPARG
8activation of MAPK activityGO:00001879.3MET, HGF
9positive regulation of transcription from RNA polymerase II promoterGO:00459449.1HGF, MET, PPARG
10extracellular matrix organizationGO:00301988.7SERPINB5, MMP13, CD151

Products for genes affiliated with Salivary Gland Cancer

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Sources for Salivary Gland Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet