MCID: SLV002
MIFTS: 52

Salivary Gland Cancer malady

Cancer diseases, Endocrine diseases, Rare diseases categories

Summaries for Salivary Gland Cancer

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your salivary glands make saliva - sometimes called spit - and empty it into your mouth through openings called ducts. saliva makes your food moist, which helps you chew and swallow. it helps you digest your food. it also cleans your mouth and contains antibodies that can kill germs. salivary gland cancer is a type of head and neck cancer. it is rare. it may not cause any symptoms, or you could notice a lump in your ear, cheek, jaw, lip, or inside the mouth fluid draining from your ear trouble swallowing or opening the mouth widely numbness, weakness, or pain in your face doctors diagnose salivary gland cancer using a physical exam, imaging tests, and a biopsy. treatment can include surgery, radiation therapy, and/or chemotherapy. nih: national cancer institute

MalaCards: Salivary Gland Cancer, also known as malignant neoplasm of salivary gland, is related to breast cancer and salivary gland cancer, adult. An important gene associated with Salivary Gland Cancer is MET (met proto-oncogene), and among its related pathways are FGF signaling pathway and Renal cell carcinoma. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and lymph node, and related mouse phenotypes are tumorigenesis and embryogenesis.

Wikipedia:66 Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are... more...

Aliases & Classifications for Salivary Gland Cancer

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

salivary gland cancer 9 11 46 35
malignant neoplasm of salivary gland 9 63
malignant neoplasm of other major salivary glands 9
malignant neoplasm of salivary gland, unspecified 9
malignant neoplasm of major salivary gland, nos 9
malignant neoplasm of major salivary gland nos 9
malignant tumor of the major salivary gland 9
malignant neoplasm of major salivary gland 9
malignant neoplasm of salivary gland duct 9
malignant neoplasm of salivary gland nos 9
malignant tumor of major salivary gland 9
malignant tumor of the salivary gland 9
malignant tumor of salivary gland 9


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Disease Ontology9 DOID:8850
MeSH36 D012468
SNOMED-CT59 187648003
ICD9CM28 142.8
ICD1026 C08

Related Diseases for Salivary Gland Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Salivary Gland Cancer family:

Salivary Gland Cancer, Adult

Diseases related to Salivary Gland Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.4SERPINB5, MMP13, MET, HGF
2salivary gland cancer, adult10.3
3salivary gland cancer, childhood10.3
4pharyngitis10.1
5mucoepidermoid carcinoma10.1
6adenoiditis10.1
7adenoid cystic carcinoma10.1
8acne10.1
9brain cancer10.1
10cervicitis10.1
11thyroiditis10.1
12oral cancer10.1
13hypoxia10.1
14proliferative vitreoretinopathy10.1MET, HGF
15papillary thyroid carcinoma10.0MET, PPARG
16malignant peripheral nerve sheath tumor10.0MMP13, MET
17proliferative diabetic retinopathy10.0MET, HGF
18neurofibroma10.0MET, MMP13
19thyroid cancer, anaplastic10.0PPARG, MET
20kidney rhabdoid cancer10.0MET, HGF
21malignant mesothelioma10.0HGF, MET
22arteriosclerosis10.0HGF, PPARG
23hepatoblastoma10.0HGF, MET
24benign mesothelioma10.0HGF, MET
25cholangiocarcinoma10.0MET, HGF
26lung benign neoplasm10.0MET, HGF
27synovial sarcoma10.0HGF, MET, MMP13
28non-small cell lung carcinoma10.0HGF, MET, PPARG
29squamous cell carcinoma of the head and neck10.0MMP13, MET, HGF
30chondrosarcoma10.0MMP13, MET
31bone carcinoma10.0SERPINB5, MMP13
32lung cancer10.0PPARG, MET, HGF
33pulmonary fibrosis10.0HGF, MMP13, PPARG
34glioblastoma multiforme10.0HGF, MET, PPARG
35pancreatic cancer10.0HGF, MET, SERPINB5
36stomach cancer10.0SERPINB5, MET, HGF
37thyroid cancer10.0MET, SERPINB5, PPARG
38adenoma9.9PPARG, SERPINB5, MET
39ovarian cancer9.9HGF, MET, SERPINB5
40follicular adenoma9.9PPARG, SERPINB5, MET, HGF
41papillary carcinoma9.9HGF, MET, SERPINB5, PPARG
42gastric adenocarcinoma9.9HGF, MET, MMP13, SERPINB5
43adenocarcinoma9.9HGF, MET, MMP13, SERPINB5
44colorectal cancer9.9PPARG, SERPINB5, MMP13, MET
45hepatocellular carcinoma9.9HGF, MET, SERPINB5
46colon cancer9.9PPARG, SERPINB5, MMP13, MET, HGF
47tongue squamous cell carcinoma9.9SERPINB5, MMP13, MET, HGF, CD151
48melanoma9.9SERPINB5, MMP13, MET, HGF, CD151
49prostate cancer9.8PPARG, SERPINB5, MMP13, MET, HGF, CD151

Graphical network of the top 20 diseases related to Salivary Gland Cancer:



Diseases related to salivary gland cancer

Symptoms for Salivary Gland Cancer

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Drugs & Therapeutics for Salivary Gland Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Salivary Gland Cancer

Drug clinical trials:

Search ClinicalTrials for Salivary Gland Cancer

Search NIH Clinical Center for Salivary Gland Cancer

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Genetic Tests for Salivary Gland Cancer

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Anatomical Context for Salivary Gland Cancer

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34MalaCards
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MalaCards organs/tissues related to Salivary Gland Cancer:

34
Salivary gland, Testes, Lymph node, Breast, Brain, Liver, Thyroid, Skin, Testis

Animal Models for Salivary Gland Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Salivary Gland Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9CD151, MET, PPARG
2MP:00053808.2HGF, MET, SERPINB5, PPARG
3MP:00053858.0PPARG, MMP13, MET, HGF, CD151
4MP:00053787.9PPARG, MMP13, MET, HGF, CD151
5MP:00107687.3PPARG, SERPINB5, MET, HGF, CD151
6MP:00053847.2CD151, HGF, MET, MMP13, SERPINB5, PPARG

Publications for Salivary Gland Cancer

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Sources:
53PubMed
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Articles related to Salivary Gland Cancer:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Risk of salivary gland cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. (22836059)
2013
2
Salivary gland cancer stem cells. (23810400)
2013
3
Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer. (23242174)
2013
4
The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. (23608756)
2013
5
Expression and function of CXCR4 in human salivary gland cancers. (22847686)
2013
6
Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells. (23517130)
2013
7
Predictors of cervical lymph node metastasis in salivary gland cancer. (23780687)
2013
8
Predictive index for lymph node management of major salivary gland cancer. (22539053)
2012
9
Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices. (22499505)
2012
10
The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation. (22445095)
2012
11
Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers. (21717524)
2012
12
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. (22240798)
2012
13
Matrix metalloproteinase (MMP)-7 in salivary gland cancer. (19929564)
2010
14
A prognostic index for predicting lymph node metastasis in minor salivary gland cancer. (19386433)
2010
15
Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease. (20191625)
2010
16
Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. (21083600)
2010
17
Treatment Results of Major Salivary Gland Cancer by Surgery with or without Postoperative Radiation Therapy. (20607079)
2010
18
Base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy. (20070763)
2009
19
Childbearing and salivary gland cancer: a population-based nested case-control study. (19680040)
2009
20
Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. (18355439)
2008
21
Immunohistochemical expression of androgen receptor in salivary gland cancers. (19391487)
2008
22
Late recurrence from salivary gland cancer: when does "cure" mean cure? (18008358)
2008
23
Brain cancers in siblings of salivary gland cancer patients suggest viral etiology? (17957796)
2008
24
Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. (16652146)
2006
25
Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. (16469527)
2006
26
Salivary gland cancer in Finland 1991--96: an evaluation of 237 cases. (15880955)
2005
27
CD151 forms a functional complex with c-Met in human salivary gland cancer cells. (16139245)
2005
28
Herceptin plus chemotherapy in relapsed and/or metastatic salivary gland cancer. (15598592)
2005
29
TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer. (15379637)
2004
30
An update on the systemic therapy of malignant salivary gland cancers: role of chemotherapy and molecular targeted agents. (15579019)
2004
31
Occupational exposures and salivary gland cancer mortality among African American and white workers in the United States. (15091292)
2004
32
High incidence of lymph node metastasis in major salivary gland cancer. (12874071)
2003
33
Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. (11944908)
2002
34
Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines. (11836575)
2002
35
Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line. (12434298)
2002
36
Nodal metastasis in major salivary gland cancer: predictive factors and effects on survival. (12162768)
2002
37
Predictors of nodal metastasis in salivary gland cancer. (12210032)
2002
38
Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. (11836610)
2002
39
Prognostic factors in major salivary gland cancer. (11568581)
2001
40
Menstrual and reproductive factors for salivary gland cancer risk in women. (10468426)
1999
41
Salivary gland cancer in the United States. (10613342)
1999
42
Exposure to nitrosamines and mortality from salivary gland cancer among rubber workers. (10535801)
1999
43
A case/control study of risk factors for major salivary gland cancer. (9482552)
1998
44
Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell. (9459148)
1998
45
Combination gene therapy for salivary gland cancer. (9599306)
1998
46
Diet and the risk of salivary gland cancer. (9230779)
1997
47
Salivary gland cancer in Alaskan natives, 1966-1980. (2820863)
1987
48
Screening for radiation-associated thyroid and salivary gland cancer. (723840)
1978
49
The association between salivary gland cancer and breast cancer. (5394367)
1969
50
Salivary gland cancer and breast cancer. (5695011)
1968

Variations for Salivary Gland Cancer

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Expression for genes affiliated with Salivary Gland Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Salivary Gland Cancer

Search GEO for disease gene expression data for Salivary Gland Cancer.

Pathways for genes affiliated with Salivary Gland Cancer

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 56Reactome, 61Thomson Reuters
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Pathways related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HGF, MET
29.6HGF, MET
39.6HGF, MET
49.6HGF, MET
59.6MET, HGF
69.6MET, HGF
79.6HGF, MET
89.6HGF, MET
99.6HGF, MET
109.5MET, PPARG
11
Show member pathways
9.4MET, CD151
12
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.4PPARG, MMP13
13
Show member pathways
9.3CD151, MMP13
149.1PPARG, MET, HGF
15
Show member pathways
9.1PPARG, MET, HGF
16
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.1HGF, MET, PPARG
17
Show member pathways
9.1HGF, MET, MMP13
188.8HGF, MET, SERPINB5

Compounds for genes affiliated with Salivary Gland Cancer

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Sources:
62Tocris Bioscience, 52PharmGKB, 46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6210.0MET, HGF
2su 112746210.0MET, HGF
3pha 6657526210.0MET, HGF
4crizotinib62 5211.0HGF, MET
5k252a4610.0MET, HGF
6ag 1478469.9HGF, MET
72-cyano-3,12-dioxoolean-1,9-dien-28-oic acid469.9MMP13, PPARG
8gefitinib46 52 1211.9HGF, MET
9alginate469.8MMP13, HGF
10l-nmma469.8HGF, PPARG
11hydroxyproline46 25 1211.8MMP13, HGF
12ndga469.8MMP13, PPARG
13geldanamycin46 52 62 1212.8HGF, MET
14losartan46 52 30 1212.8PPARG, HGF
15aprotinin46 1210.7HGF, MMP13
16phenobarbital46 30 52 1212.7HGF, PPARG
17suramin46 30 1211.7HGF, MET
18carnitine469.7PPARG, HGF
19ccl446 3010.5MMP13, MET, HGF
20sp 60012546 6210.5MMP13, HGF
21herbimycin a46 6210.5MMP13, MET, HGF
2212-o-tetradecanoylphorbol 13-acetate469.5MMP13, MET, HGF
23vitamin d469.5HGF, MET, PPARG
24pd 98,059469.5HGF, MET, MMP13
25ly294002469.5HGF, MET, PPARG
26glycosaminoglycan469.4MET, MMP13
27actinomycin d469.4HGF, MET, MMP13
28thymidine46 2510.4MMP13, MET, HGF
29heparin46 30 25 1212.4MMP13, MET, HGF
30retinoid469.4PPARG, MMP13, HGF
31indomethacin46 30 62 1212.4HGF, MMP13, PPARG
32sb 20358046 6210.4HGF, MMP13, PPARG
33ornithine46 2510.3HGF, MET
34p002469.1SERPINB5, MMP13, MET
35cisplatin46 52 62 1212.1HGF, MET, SERPINB5
36dexamethasone46 52 30 1212.1HGF, MMP13, PPARG
37phosphatidylinositol469.1HGF, MET, MMP13
38aspirin46 52 30 2512.1HGF, SERPINB5, PPARG
39genistein46 30 62 3 25 1214.0PPARG, MMP13, MET, HGF
40pge2469.0HGF, MET, MMP13, PPARG
41cycloheximide469.0HGF, MET, MMP13, PPARG
42retinoic acid46 2510.0HGF, MET, MMP13, PPARG
43pdtc468.7PPARG, SERPINB5, MET, HGF
44paraffin468.7HGF, MET, MMP13, SERPINB5
45testosterone46 62 25 1211.7HGF, MET, SERPINB5, PPARG
46lipid468.6PPARG, SERPINB5, MET, HGF
47serine468.6HGF, MET, MMP13, SERPINB5
48vegf468.2PPARG, SERPINB5, MMP13, MET, HGF
49estrogen468.2HGF, MET, MMP13, SERPINB5, PPARG
50matrigel468.1CD151, HGF, MET, MMP13, SERPINB5

GO Terms for genes affiliated with Salivary Gland Cancer

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17Gene Ontology
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Biological processes related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:19012999.8HGF, MET
2myoblast proliferationGO:0514509.8HGF, MET
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8HGF, MET
4placenta developmentGO:0018909.7MET, PPARG
5liver developmentGO:0018899.6HGF, MET
6organ regenerationGO:0311009.6PPARG, HGF
7glucose homeostasisGO:0425939.4MET, PPARG
8activation of MAPK activityGO:0001879.3MET, HGF
9positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, MET, PPARG
10extracellular matrix organizationGO:0301988.7SERPINB5, MMP13, CD151

Products for genes affiliated with Salivary Gland Cancer

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  • Antibodies
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Sources for Salivary Gland Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet