MCID: SLV002
MIFTS: 54

Salivary Gland Cancer malady

Cancer diseases, Endocrine diseases, Oral diseases, Rare diseases categories
Download this MalaCard

Summaries for Salivary Gland Cancer

About this section


Fully expand this MalaCard
MedlinePlus:33 Your salivary glands make saliva - sometimes called spit - and empty it into your mouth through openings called ducts. saliva makes your food moist, which helps you chew and swallow. it helps you digest your food. it also cleans your mouth and contains antibodies that can kill germs. salivary gland cancer is a type of head and neck cancer. it is rare. it may not cause any symptoms, or you could notice a lump in your ear, cheek, jaw, lip, or inside the mouth fluid draining from your ear trouble swallowing or opening the mouth widely numbness, weakness, or pain in your face doctors diagnose salivary gland cancer using a physical exam, imaging tests, and a biopsy. treatment can include surgery, radiation therapy, and/or chemotherapy. nih: national cancer institute

MalaCards based summary: Salivary Gland Cancer, also known as malignant tumor of the major salivary gland, is related to breast cancer and adenocarcinoma. An important gene associated with Salivary Gland Cancer is MET (met proto-oncogene), and among its related pathways are FGF signaling pathway and Renal cell carcinoma. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include the salivary gl, salivary gland and testes, and related mouse phenotypes are tumorigenesis and embryogenesis.

Disease Ontology:8 An oral cavity cancer that is located in the salivary gland.

Wikipedia:65 Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are... more...

Aliases & Classifications for Salivary Gland Cancer

About this section

Salivary Gland Cancer, Aliases & Descriptions:

Name: Salivary Gland Cancer 8 10 44 33
Malignant Tumor of the Major Salivary Gland 8 62
Malignant Neoplasm of Major Salivary Gland 8 62
Malignant Tumor of the Salivary Gland 8 62
 
Malignant Neoplasm of Salivary Gland 8 62
Salivary Gland Carcinoma 8 62
Malignant Neoplasm of Salivary Gland Duct 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Endocrine diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:8850, DOID:0050904
MeSH34 D012468
SNOMED-CT57 187648003
ICD9CM27 142.8

Related Diseases for Salivary Gland Cancer

About this section

Diseases in the Salivary Gland Cancer family:

Salivary Gland Cancer, Adult

Diseases related to Salivary Gland Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.1MET, HGF, SERPINB5, MMP13
2adenocarcinoma30.0SERPINB5, MMP13, MET, HGF
3adenoma29.9MET, SERPINB5, PPARG
4endotheliitis10.4
5brooke-spiegler syndrome10.3
6hidradenoma10.3
7myoepithelioma10.3
8polymorphous low-grade adenocarcinoma10.3
9mucoepidermoid salivary gland carcinoma10.3
10salivary gland cancer, adult10.3
11salivary gland cancer, childhood10.3
12salivary gland tumor10.3
13proliferative vitreoretinopathy10.2MET, HGF
14papillary thyroid carcinoma10.2MET, PPARG
15malignant peripheral nerve sheath tumor10.2MMP13, MET
16proliferative diabetic retinopathy10.2MET, HGF
17neurofibroma10.2MET, MMP13
18thyroid cancer, anaplastic10.2MET, PPARG
19kidney rhabdoid cancer10.2MET, HGF
20pleomorphic adenoma10.2
21salivary gland adenoid cystic carcinoma10.2
22vaccinia10.2
23arteriosclerosis10.2HGF, PPARG
24hepatoblastoma10.2HGF, MET
25malignant mesothelioma10.1HGF, MET
26acne10.1
27pharyngitis10.1
28mucoepidermoid carcinoma10.1
29adenoiditis10.1
30brain cancer10.1
31cervicitis10.1
32parotid gland cancer10.1
33sublingual gland cancer10.1
34thyroiditis10.1
35oral cancer10.1
36hypoxia10.1
37benign epithelial tumor of the salivary glands10.1
38malignant epithelial tumor of the salivary glands10.1
39cholangiocarcinoma10.1HGF, MET
40lung benign neoplasm10.1MET, HGF
41synovial sarcoma10.0MMP13, HGF, MET
42non-small cell lung carcinoma10.0PPARG, HGF, MET
43squamous cell carcinoma of the head and neck10.0MET, MMP13, HGF
44chondrosarcoma10.0MMP13, MET
45lung cancer10.0MET, HGF, PPARG
46bone cancer10.0SERPINB5, MMP13
47pulmonary fibrosis10.0HGF, PPARG, MMP13
48glioblastoma10.0HGF, MET, PPARG
49pancreatic cancer9.9MET, HGF, SERPINB5
50stomach cancer9.9MET, HGF, SERPINB5

Graphical network of the top 20 diseases related to Salivary Gland Cancer:



Diseases related to salivary gland cancer

Symptoms for Salivary Gland Cancer

About this section

Drugs & Therapeutics for Salivary Gland Cancer

About this section

Drug clinical trials:

Search ClinicalTrials for Salivary Gland Cancer

Search NIH Clinical Center for Salivary Gland Cancer

Genetic Tests for Salivary Gland Cancer

About this section

Anatomical Context for Salivary Gland Cancer

About this section

MalaCards organs/tissues related to Salivary Gland Cancer:

32
Salivary gland, Testes, Lymph node, Breast, Brain, Liver, Thyroid, Skin, Testis

FMA organs/tissues related to Salivary Gland Cancer:

14
The salivary gl

Animal Models for Salivary Gland Cancer or affiliated genes

About this section

MGI Mouse Phenotypes related to Salivary Gland Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9CD151, MET, PPARG
2MP:00053808.2HGF, MET, SERPINB5, PPARG
3MP:00053858.0PPARG, MMP13, MET, HGF, CD151
4MP:00053787.9PPARG, MMP13, MET, HGF, CD151
5MP:00107687.3PPARG, SERPINB5, MET, HGF, CD151
6MP:00053847.2CD151, HGF, MET, MMP13, SERPINB5, PPARG

Publications for Salivary Gland Cancer

About this section

Articles related to Salivary Gland Cancer:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Salivary Gland Cancer in BRCA-Positive Families : A Retrospective Review. (25257187)
2014
2
The Impact of Demographic and Socioeconomic Factors on Major Salivary Gland Cancer Survival. (24647644)
2014
3
Risk of salivary gland cancer after childhood cancer: a report from the Childhood Cancer Survivor Study. (22836059)
2013
4
Salivary gland cancer stem cells. (23810400)
2013
5
Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer. (23242174)
2013
6
The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. (23608756)
2013
7
Expression and function of CXCR4 in human salivary gland cancers. (22847686)
2013
8
Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells. (23517130)
2013
9
Predictors of cervical lymph node metastasis in salivary gland cancer. (23780687)
2013
10
Predictive index for lymph node management of major salivary gland cancer. (22539053)
2012
11
Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices. (22499505)
2012
12
The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation. (22445095)
2012
13
Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers. (21717524)
2012
14
Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. (22240798)
2012
15
Matrix metalloproteinase (MMP)-7 in salivary gland cancer. (19929564)
2010
16
A prognostic index for predicting lymph node metastasis in minor salivary gland cancer. (19386433)
2010
17
Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease. (20191625)
2010
18
Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. (21083600)
2010
19
Treatment Results of Major Salivary Gland Cancer by Surgery with or without Postoperative Radiation Therapy. (20607079)
2010
20
Base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy. (20070763)
2009
21
Childbearing and salivary gland cancer: a population-based nested case-control study. (19680040)
2009
22
Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. (18355439)
2008
23
Immunohistochemical expression of androgen receptor in salivary gland cancers. (19391487)
2008
24
Brain cancers in siblings of salivary gland cancer patients suggest viral etiology? (17957796)
2008
25
Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. (16652146)
2006
26
Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. (16469527)
2006
27
Salivary gland cancer in Finland 1991--96: an evaluation of 237 cases. (15880955)
2005
28
CD151 forms a functional complex with c-Met in human salivary gland cancer cells. (16139245)
2005
29
Herceptin plus chemotherapy in relapsed and/or metastatic salivary gland cancer. (15598592)
2005
30
TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer. (15379637)
2004
31
An update on the systemic therapy of malignant salivary gland cancers: role of chemotherapy and molecular targeted agents. (15579019)
2004
32
Occupational exposures and salivary gland cancer mortality among African American and white workers in the United States. (15091292)
2004
33
High incidence of lymph node metastasis in major salivary gland cancer. (12874071)
2003
34
Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. (11944908)
2002
35
Expression of peroxisome proliferator-activated receptor gamma and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines. (11836575)
2002
36
Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line. (12434298)
2002
37
Nodal metastasis in major salivary gland cancer: predictive factors and effects on survival. (12162768)
2002
38
Predictors of nodal metastasis in salivary gland cancer. (12210032)
2002
39
Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. (11836610)
2002
40
Prognostic factors in major salivary gland cancer. (11568581)
2001
41
Menstrual and reproductive factors for salivary gland cancer risk in women. (10468426)
1999
42
Salivary gland cancer in the United States. (10613342)
1999
43
Exposure to nitrosamines and mortality from salivary gland cancer among rubber workers. (10535801)
1999
44
A case/control study of risk factors for major salivary gland cancer. (9482552)
1998
45
Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell. (9459148)
1998
46
Diet and the risk of salivary gland cancer. (9230779)
1997
47
Salivary gland cancer in Alaskan natives, 1966-1980. (2820863)
1987
48
Screening for radiation-associated thyroid and salivary gland cancer. (723840)
1978
49
The association between salivary gland cancer and breast cancer. (5394367)
1969
50
Salivary gland cancer and breast cancer. (5695011)
1968

Variations for Salivary Gland Cancer

About this section

Expression for genes affiliated with Salivary Gland Cancer

About this section
Expression patterns in normal tissues for genes affiliated with Salivary Gland Cancer

Search GEO for disease gene expression data for Salivary Gland Cancer.

Pathways for genes affiliated with Salivary Gland Cancer

About this section

Pathways related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HGF, MET
29.6HGF, MET
39.6HGF, MET
49.6HGF, MET
59.6MET, HGF
69.6MET, HGF
79.6HGF, MET
89.6HGF, MET
99.6HGF, MET
109.5MET, PPARG
11
Show member pathways
9.4MET, CD151
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.4PPARG, MMP13
13
Show member pathways
9.3CD151, MMP13
149.1PPARG, MET, HGF
15
Show member pathways
9.1PPARG, MET, HGF
16
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1HGF, MET, PPARG
17
Show member pathways
9.1HGF, MET, MMP13
188.8HGF, MET, SERPINB5

Compounds for genes affiliated with Salivary Gland Cancer

About this section

Compounds related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6110.0MET, HGF
2su 112746110.0MET, HGF
3pha 6657526110.0MET, HGF
4crizotinib61 5011.0HGF, MET
5k252a4410.0MET, HGF
6ag 1478449.9HGF, MET
72-cyano-3,12-dioxoolean-1,9-dien-28-oic acid449.9MMP13, PPARG
8gefitinib44 50 1111.9HGF, MET
9alginate449.8MMP13, HGF
10l-nmma449.8HGF, PPARG
11hydroxyproline44 24 1111.8MMP13, HGF
12ndga449.8MMP13, PPARG
13geldanamycin44 50 61 1112.8HGF, MET
14losartan44 50 28 1112.8PPARG, HGF
15aprotinin44 1110.7HGF, MMP13
16phenobarbital44 28 50 1112.7HGF, PPARG
17suramin44 28 1111.7HGF, MET
18carnitine449.7PPARG, HGF
19ccl444 2810.5MMP13, MET, HGF
20sp 60012544 6110.5MMP13, HGF
21herbimycin a44 6110.5MMP13, MET, HGF
2212-o-tetradecanoylphorbol 13-acetate449.5MMP13, MET, HGF
23vitamin d449.5HGF, MET, PPARG
24pd 98,059449.5HGF, MET, MMP13
25ly294002449.5HGF, MET, PPARG
26glycosaminoglycan449.4MET, MMP13
27actinomycin d449.4HGF, MET, MMP13
28thymidine44 2410.4MMP13, MET, HGF
29heparin44 28 24 1112.4MMP13, MET, HGF
30retinoid449.4PPARG, MMP13, HGF
31indomethacin44 28 61 1112.4HGF, MMP13, PPARG
32sb 20358044 6110.4HGF, MMP13, PPARG
33ornithine44 2410.3HGF, MET
34p002449.1SERPINB5, MMP13, MET
35cisplatin44 50 61 1112.1HGF, MET, SERPINB5
36dexamethasone44 50 28 1112.1HGF, MMP13, PPARG
37phosphatidylinositol449.1HGF, MET, MMP13
38aspirin44 50 28 2412.1HGF, SERPINB5, PPARG
39genistein44 28 61 2 24 1114.0PPARG, MMP13, MET, HGF
40pge2449.0HGF, MET, MMP13, PPARG
41cycloheximide449.0HGF, MET, MMP13, PPARG
42retinoic acid44 2410.0HGF, MET, MMP13, PPARG
43pdtc448.7PPARG, SERPINB5, MET, HGF
44paraffin448.7HGF, MET, MMP13, SERPINB5
45testosterone44 61 24 1111.7HGF, MET, SERPINB5, PPARG
46lipid448.6PPARG, SERPINB5, MET, HGF
47serine448.6HGF, MET, MMP13, SERPINB5
48vegf448.2PPARG, SERPINB5, MMP13, MET, HGF
49estrogen448.2HGF, MET, MMP13, SERPINB5, PPARG
50matrigel448.1CD151, HGF, MET, MMP13, SERPINB5

GO Terms for genes affiliated with Salivary Gland Cancer

About this section

Biological processes related to Salivary Gland Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:19012999.8HGF, MET
2myoblast proliferationGO:0514509.8HGF, MET
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.8HGF, MET
4placenta developmentGO:0018909.7MET, PPARG
5liver developmentGO:0018899.6HGF, MET
6organ regenerationGO:0311009.6PPARG, HGF
7glucose homeostasisGO:0425939.4MET, PPARG
8activation of MAPK activityGO:0001879.3MET, HGF
9positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, MET, PPARG
10extracellular matrix organizationGO:0301988.7SERPINB5, MMP13, CD151

Products for genes affiliated with Salivary Gland Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Salivary Gland Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet