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MCID: SLV003
MIFTS: 47

Salivary Gland Disease malady

Categories: Oral diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Salivary Gland Disease

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Aliases & Descriptions for Salivary Gland Disease:

Name: Salivary Gland Disease 12 51 29 14
Salivary Gland Diseases 52 69
Non-Neoplastic Salivary Gland Disorder 69
Non-Neoplastic Salivary Gland Disease 12
Salivary Gland Disorders 41

Classifications:

MalaCards categories:
Anatomical: Oral diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10854
ICD9CM 35 527.8
UMLS 69 C0029773
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Summaries for Salivary Gland Disease

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MedlinePlus : 41 your salivary glands are in your mouth. you have three pairs of major salivary glands and hundreds of small (minor) glands. they make saliva (spit) and empty it into your mouth through openings called ducts. saliva makes your food moist, which helps you chew and swallow. it helps you digest your food. it also cleans your mouth and contains antibodies that can kill germs. problems with salivary glands can cause them to become irritated and swollen. you may have symptoms such as a bad taste in your mouth difficulty opening your mouth dry mouth pain in your face or mouth swelling of your face or neck causes of salivary gland problems include infections, obstruction, or cancer. problems can also be due to other disorders, such as mumps or sjogren's syndrome.

MalaCards based summary : Salivary Gland Disease, also known as salivary gland diseases, is related to igg4-related disease and jaw cancer, and has symptoms including halitosis, oral manifestations and snoring. An important gene associated with Salivary Gland Disease is CDSN (Corneodesmosin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Calcium carbonate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include salivary gland and lymph node, and related phenotypes are hematopoietic system and immune system

NINDS : 51 Cytomegalovirus (CMV) is a virus found throughout the world that infects between 50 to 80 percent of all adults in the United States by the age of 40.  CMV is in the same family of viruses that causes cold sores (herpes simplex virus), infectious mononucleosis (Epstein-Barr virus), and chickenpox/shingles (varicella zoster virus).    Most people who acquire CVM as children or adults display no signs of illness or have mild symptoms such as fever, fatigue, or tender lymph nodes.  People with a compromised immune system may have more severe forms of infection involving the nervous system.

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Related Diseases for Salivary Gland Disease

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Diseases related to Salivary Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 igg4-related disease 10.8
2 jaw cancer 10.3 CD40LG CDSN
3 toxocariasis 10.3 CD79A TRIM21
4 facial nerve neoplasm 10.3 CD40LG TRIM21
5 alcoholic neuropathy 10.3 CD40LG CD79A
6 camptodactyly vertebral fusion 10.3 CD40LG CD79A
7 cannabis dependence 10.3 CD40LG CDSN
8 spinal polio 10.3 CD40LG CD79A
9 rabies 10.3 CD40LG CD79A
10 unilateral retinoblastoma 10.3 CD40LG CD79A
11 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
12 delta chain disease 10.3 CD40LG CD79A
13 discitis 10.3 CD40LG CD79A
14 vitamin k deficiency hemorrhagic disease 10.3 CD79A TRIM21
15 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
16 trichostrongyloidiasis 10.3 CD40LG CD79A
17 nerve compression syndrome 10.3 CD40LG CDSN
18 spastic ataxia 7, autosomal dominant 10.3 CD40LG TRIM21
19 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
20 adamantinoma of long bones 10.3 CDSN TRIM21
21 pediatric meningioma 10.3 CD40LG CD79A
22 tonsil cancer 10.3 CD40LG CD79A
23 indomethacin antenatal infection 10.3 CD40LG CD79A
24 beach ear 10.3 CD40LG CD79A
25 acute kidney tubular necrosis 10.3 CD40LG CD79A
26 atheroembolism of kidney 10.3 CD40LG CD79A
27 ritscher-schinzel syndrome 1 10.3 CD40LG CD79A
28 diabetic angiopathy 10.3 CD40LG CD79A
29 hyperparathyroidism, primary, caused by water clear cell hyperplasia 10.3 CD40LG TNFSF13B
30 muscular dystrophy 10.3 CD40LG CD79A
31 dumping syndrome 10.3 CD40LG CD79A
32 striatonigral degeneration 10.3 CD40LG CD79A
33 ciliary body spindle cell melanoma 10.3 CD40LG CD79A
34 purulent endophthalmitis 10.3 CD40LG CD79A
35 mu chain disease 10.3 CD40LG CD79A
36 homocystinuria 10.3 CD40LG CD79A
37 mental retardation, autosomal dominant 19 10.2 CD40LG CD79A
38 hemangioma of orbit 10.2 CD40LG CD79A
39 leiomyosarcoma 10.2 CD40LG CD79A
40 prostate carcinoma in situ 10.2 CD4 CD40LG
41 gestational diabetes 10.2 CD40LG CD79A
42 heart septal defect 10.2 CD40LG CD79A CDSN
43 chronic duodenal ileus 10.2 CD4 CD40LG
44 cysticercosis 10.2 CD4 CD40LG
45 asthenopia 10.2 CDSN HSPG2 TRIM21
46 atypical breast papilloma 10.2 CD4 CD40LG
47 angiolipoma 10.2 CD4 CD40LG
48 odontogenic myxoma 10.2 CD40LG CD79A
49 lymph node adenoid cystic carcinoma 10.2 CD40LG CD79A TRIM21
50 46 xy gonadal dysgenesis 10.2 CD4 CD79A

Graphical network of the top 20 diseases related to Salivary Gland Disease:



Diseases related to Salivary Gland Disease
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Symptoms & Phenotypes for Salivary Gland Disease

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UMLS symptoms related to Salivary Gland Disease:


halitosis, oral manifestations, snoring

MGI Mouse Phenotypes related to Salivary Gland Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD4 CD40LG CD79A CD8A HSPG2 RAG1
2 immune system MP:0005387 9.23 CD8A HSPG2 RAG1 TNFSF13B TRIM21 CD4
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Drugs & Therapeutics for Salivary Gland Disease

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Drugs for Salivary Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 417)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium carbonate Approved Phase 4 471-34-1
2
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
3
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
5
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
6
Docosanol Approved, Investigational Phase 4 30303-65-2, 661-19-8 12620
7
Cosyntropin Approved Phase 4 16960-16-0 16129617
8
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 51-43-4 5816
9
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
10
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
11
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
12
Cevimeline Approved Phase 4 107233-08-9 83898 25137844
13
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
14
Glycerol Approved, Experimental Phase 4,Phase 2 56-81-5 753
15
Pilocarpine Approved Phase 4,Phase 3,Phase 2 54-71-7, 92-13-7 5910
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
17
Oxybutynin Approved, Investigational Phase 4,Phase 2 5633-20-5 4634
18
Dehydroepiandrosterone Approved, Nutraceutical Phase 4,Phase 2 53-43-0 9860744
19
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
20
Butyric Acid Experimental Phase 4,Phase 1,Phase 2 107-92-6 264
21 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
22 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
23 Antacids Phase 4,Phase 2
24 Antifungal Agents Phase 4,Phase 2,Phase 1
25 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
28 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Anti-Ulcer Agents Phase 4,Phase 2
30 Calcineurin Inhibitors Phase 4,Phase 2
31 Calcium, Dietary Phase 4
32 Dermatologic Agents Phase 4,Phase 2
33 Gallopamil Phase 4
34 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
35 glucocorticoids Phase 4,Phase 3,Phase 2
36 Hormone Antagonists Phase 4,Phase 3,Phase 2
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
39 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Acyclovir Phase 4
41 Antiviral Agents Phase 4,Phase 2,Phase 1
42 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1
43 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1
44 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1
45 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1
46 Racepinephrine Phase 4,Phase 2,Phase 3,Phase 1
47 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Cholinergic Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 487)
id Name Status NCT ID Phase
1 Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue Unknown status NCT00543166 Phase 4
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4
4 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4
5 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4
6 Effects of Mucoprotective Product on Xerostomia Completed NCT01316393 Phase 4
7 Effect of Korean Red Ginseng (KRG) on Dry Mouth Completed NCT00911768 Phase 4
8 Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia Completed NCT00466388 Phase 4
9 Evaluation of an Electro-stimulator for the Treatment of Xerostomia Completed NCT00509808 Phase 4
10 Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops Completed NCT01850979 Phase 4
11 A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study Completed NCT02049112 Phase 4
12 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease Completed NCT02004067 Phase 4
13 Immunogenicity and Safety of Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00126997 Phase 4
14 A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment Completed NCT00438048 Phase 4
15 Immunogenicity and Safety of Hepatitis A Vaccine Given at the Same Time of Measles, Mumps, Rubella Combined Vaccine Completed NCT00313950 Phase 4
16 Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention Completed NCT00631358 Phase 4
17 Comparative Study of the Immunogenicity of MMR (Measles, Mumps and Rubella) Single Dose and Multidose Presentations Completed NCT01777529 Phase 4
18 Measles, Mumps, and Rubella (MMR) Immunity in College Students Completed NCT00962819 Phase 4
19 Effect of Pilocarpine in Patients With Xerostomia Recruiting NCT02982577 Phase 4
20 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Recruiting NCT02880865 Phase 4
21 A Research About Nutrition Impact for Local Advanced Nasopharyngeal Carcinoma Patients Recruiting NCT02948699 Phase 4
22 Stereotactic Body Radiotherapy for Head and Neck Tumors Active, not recruiting NCT01344356 Phase 4
23 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4
24 Use of Biotene Moisturizing Mouth Spray for Xerostomia Associated With Oral Oxybutynin Use Not yet recruiting NCT02522936 Phase 4
25 Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia Unknown status NCT00081029 Phase 3
26 Application of Botulinum Toxin Type A in Salivary Glands in the Treatment of Drooling in Patients With Cerebral Palsy Unknown status NCT01489904 Phase 2, Phase 3
27 Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation Unknown status NCT01174329 Phase 2, Phase 3
28 Platelet -Rich Plasma (PRP) Injection for the Treatment of Severe Dry Eye Unknown status NCT02257957 Phase 3
29 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
30 Efficacy of Tocilizumab in Primary Sjögren's Syndrome. Unknown status NCT01782235 Phase 2, Phase 3
31 Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer Unknown status NCT00022373 Phase 3
32 Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases Completed NCT02425176 Phase 2, Phase 3
33 Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects Completed NCT01994109 Phase 3
34 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity Completed NCT01652001 Phase 2, Phase 3
35 Metoclopramide as Treatment of Clozapine-induced Hypersalivation Completed NCT02222220 Phase 3
36 Benzamide Derivates as Treatment of Clozapine-induced Hypersalivation Completed NCT00534573 Phase 3
37 OGT Spray in the Management of Xerostomia in the Elderly Completed NCT00350350 Phase 3
38 Tolerance and Efficacy of Rituximab in Sjogren's Disease Completed NCT00740948 Phase 2, Phase 3
39 Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients Completed NCT00168181 Phase 3
40 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00656513 Phase 2, Phase 3
41 Intravenous Versus Subcutaneous Amifostine in Prevention of Xerostomia After RT for Head and Neck Carcinomas Completed NCT00158691 Phase 3
42 A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer Completed NCT02941276 Phase 3
43 Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS) Completed NCT00125203 Phase 2, Phase 3
44 Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions Completed NCT02091739 Phase 3
45 Hydroxychloroquine Versus Placebo in Primary Sjögren's Syndrome Completed NCT00632866 Phase 3
46 Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions Completed NCT00491894 Phase 3
47 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
48 Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren's Syndrome Completed NCT01601028 Phase 3
49 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127023 Phase 3
50 Immunogenicity and Safety of a Combined Vaccine to Prevent Measles, Mumps, Rubella and Chickenpox Diseases Completed NCT00127010 Phase 3

Search NIH Clinical Center for Salivary Gland Disease

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Genetic Tests for Salivary Gland Disease

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Genetic tests related to Salivary Gland Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Salivary Glands 29
Sources

Anatomical Context for Salivary Gland Disease

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MalaCards organs/tissues related to Salivary Gland Disease:

39
Salivary Gland, Lymph Node
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Publications for Salivary Gland Disease

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Articles related to Salivary Gland Disease:

(show top 50) (show all 71)
id Title Authors Year
1
Distinct BK polyomavirus non-coding control region (NCCR) variants in oral fluids of HIV- associated Salivary Gland Disease patients. ( 27085139 )
2016
2
HIV-associated salivary gland disease - clinical or imaging diagnosis? ( 25187268 )
2014
3
Human prominin-1 (CD133) is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form. ( 24911657 )
2014
4
Focused review of investigation, management and outcomes of salivary gland disease in specialty-specific journals. ( 24792858 )
2014
5
Salivary gland disease in SjAPgren's syndrome: sialoadenitis to lymphoma. ( 24287195 )
2014
6
Salivary gland diseases: infections, sialolithiasis and mucoceles. ( 24862601 )
2014
7
Oral mucocele/ranula: Another human immunodeficiency virus-related salivary gland disease? ( 25446909 )
2014
8
Is sialendoscopy an effective treatment for obstructive salivary gland disease? ( 23404254 )
2013
9
Sialendoscopy for the management of obstructive salivary gland disease: a systematic review and meta-analysis. ( 22710505 )
2012
10
Natural killer cells regulate murine cytomegalovirus-induced sialadenitis and salivary gland disease. ( 22156514 )
2012
11
Viruses and salivary gland disease (SGD): lessons from HIV SGD. ( 21441486 )
2011
12
Salivary gland disease. ( 20428015 )
2010
13
Diagnostic discussion. HIV-associated salivary gland disease (HIVSGD)-HIV related parotid cysts. ( 20443533 )
2010
14
HIV-associated salivary gland disease. ( 19608050 )
2009
15
Recent advances in the management of salivary gland disease. ( 19651463 )
2009
16
Clinical implications of the neck in salivary gland disease. ( 18603202 )
2008
17
Advances in the treatment of salivary gland disease. ( 17194041 )
2006
18
A revolution in the management of obstructive salivary gland disease. ( 16512096 )
2006
19
Salivary gland disease in pediatric HIV patients: an update. ( 15272653 )
2004
20
Clinical conditions and lesions mimicking salivary gland disease: Part 2. ( 15633830 )
2004
21
Modern management of obstructive salivary gland disease. ( 16479855 )
2004
22
Clinical conditions and lesions mimicking salivary gland disease, part 1. ( 15622887 )
2004
23
Salivary gland disease in HIV/AIDS and primary SjAPgren's syndrome: analysis of collagen I distribution and histopathology in American and African patients. ( 12969229 )
2003
24
The genu of the submandibular duct--is the angle significant in salivary gland disease? ( 11803383 )
2002
25
The role of MRI in facial swelling due to presumed salivary gland disease. ( 11718383 )
2001
26
Benign salivary gland disease. ( 11480124 )
2001
27
Diagnosing salivary gland disease. ( 11462349 )
2001
28
Imaging of salivary gland disease. ( 10670049 )
2000
29
Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study. Women's Interagency HIV Study. ( 10846124 )
2000
30
The surgical management of salivary gland disease of the sublingual gland and floor of mouth. ( 11905350 )
1998
31
Bilateral and multicystic major salivary gland disease: a rare presentation of primary SjAPgren's syndrome. ( 10209623 )
1998
32
Lupus erythematosus profundus around the salivary glands: a case resembling submandibular salivary gland disease. ( 9229369 )
1997
33
An association between salivary gland disease and serological abnormalities in SjAPgren's syndrome. ( 9385581 )
1997
34
Ultrasonography in the investigation of salivary gland disease. ( 8299828 )
1993
35
Ultrasound in salivary gland disease. ( 8397364 )
1993
36
Salivary autoantibodies in HIV-associated salivary gland disease. ( 8315599 )
1993
37
HIV-salivary gland disease. Salivary scintiscanning with technetium pertechnetate. ( 8394560 )
1993
38
Spectrum of salivary gland disease in HIV-infected patients: characterization with Ga-67 citrate imaging. ( 1509064 )
1992
39
Natural history of HIV-associated salivary gland disease. ( 1407995 )
1992
40
HIV-associated salivary gland disease: a review. ( 1549310 )
1992
41
Salivary gland disease in infancy and childhood: non-malignant lesions. ( 1494185 )
1992
42
Serum anti-SS-B/La and IgA rheumatoid factor are markers of salivary gland disease activity in primary SjAPgren's syndrome. ( 1445455 )
1992
43
Sialochemistry in human immunodeficiency virus associated salivary gland disease. ( 1556696 )
1992
44
Salivary gland disease in dogs and cats: 245 cases (1985-1988). ( 2010345 )
1991
45
Oral medicine in practice: salivary gland disease. ( 2182095 )
1990
46
Does HIV cause salivary gland disease? ( 2517203 )
1989
47
Investigation of salivary gland disease. ( 2656237 )
1989
48
An approach to the diagnosis and management of salivary gland disease. ( 2721417 )
1989
49
Technetium-99m pertechnetate and gallium-67 imaging in salivary gland disease. ( 2548796 )
1989
50
Clinical assessment and diagnosis of immunologically mediated salivary gland disease in SjAPgren's syndrome. ( 2789655 )
1989
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Variations for Salivary Gland Disease

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Expression for Salivary Gland Disease

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Search GEO for disease gene expression data for Salivary Gland Disease.
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Pathways for Salivary Gland Disease

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Pathways related to Salivary Gland Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Class I MHC mediated antigen processing and presentation 62
Show member pathways
 13.02 CD4 CD40LG CD79A CD8A SIGLEC12 TRIM21
2
NF-kappaB Signaling 4
11.85 CD40LG CD79A CD8A RAG1 TNFSF13B
3
Cell adhesion molecules (CAMs) 37
11.66 CD4 CD40LG CD8A
4
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 62
11.56 CD40LG CD8A SIGLEC12
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 61
11.4 CD4 CD79A CD8A
6
Primary immunodeficiency 37
10.59 CD4 CD40LG CD79A CD8A RAG1
Sources

GO Terms for Salivary Gland Disease

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Cellular components related to Salivary Gland Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 T cell receptor complex GO:0042101 8.96 CD4 CD8A
2 external side of plasma membrane GO:0009897 8.92 CD4 CD40LG CD79A CD8A

Biological processes related to Salivary Gland Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.73 CD4 CD79A CD8A TNFSF13B
2 T cell costimulation GO:0031295 9.5 CD4 CD40LG TNFSF13B
3 B cell differentiation GO:0030183 9.43 CD40LG CD79A RAG1
4 positive regulation of calcium-mediated signaling GO:0050850 9.4 CD4 CD8A
5 positive regulation of viral entry into host cell GO:0046598 9.37 CD4 TRIM21
6 immune response GO:0006955 9.35 CD4 CD40LG CD8A RAG1 TNFSF13B
7 positive regulation of T cell proliferation GO:0042102 9.33 CD4 CD40LG TNFSF13B
8 immunoglobulin secretion GO:0048305 8.62 CD40LG TNFSF13B

Molecular functions related to Salivary Gland Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.02 CD4 CD79A CD8A CDSN RAG1
Sources

Sources for Salivary Gland Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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