MCID: SRC013
MIFTS: 69

Sarcoidosis malady

Immune diseases category

Summaries for Sarcoidosis

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42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. the granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. the course of the disease varies from person to person. it often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. for those who need treatment, anti-inflammatory medications can help. last updated: 3/30/2010

MalaCards: Sarcoidosis, also known as boeck sarcoid, any site, is related to pulmonary sarcoidosis and tuberculosis. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Akt Signaling and PAK Pathway. The compounds nitric oxide and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are immune system and hematopoietic system.

MedlinePlus:33 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

Wikipedia:63 Sarcoidosis (from sarc meaning \"flesh\", -oid, \"like\", and -osis, \"diseased or abnormal... more...

Aliases & Classifications for Sarcoidosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

sarcoidosis 8 42 10 44 33 60
boeck sarcoid, any site 8
lymphogranulomatosis 8
schaumann's disease 42
sarcoid of boeck 42


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Disease Ontology8 DOID:11335
NCIt39 C34995
MeSH34 D012507
SNOMED-CT56 31541009, 154425004
ICD9CM27 135
ICD1025 D86, D86.9

Related Diseases for Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases in the Sarcoidosis 1 family:

sarcoidosis Sarcoidosis 2
Sarcoidosis 3

Diseases related to Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 493)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary sarcoidosis31.7ACE, IL12RB1, IL9, IL12B, IL18, IL2RA
2tuberculosis30.8NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL9
3pulmonary fibrosis30.7CXCR3, PDGFB, SFTPD, CCL3
4idiopathic pulmonary fibrosis30.7IL9, IL18, CXCL9, CXCL5, CXCR3, CR1
5hepatitis30.6CR1, HLA-DRB1, PDGFB
6hypercalcemia30.6LTA, CCL3
7hypertension30.5ACE
8pulmonary tuberculosis30.5IL12RB1, IL12B, IL18, IL2RA, CD80, HLA-DRB1
9uveitis30.4ACE, NOD2, IL9, IL2RA, CXCL9, CXCR3
10pneumonia30.4CXCL5, CR1, TNF, SFTPD, CCL3
11lupus erythematosus30.4IL18
12hepatitis c30.4IL12B, IL18, CXCR3, CR1, HLA-DRB1, TNF
13thyroiditis30.4HLA-DRB1
14asthma30.3IL12B, TNF
15systemic lupus erythematosus30.3NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCR3
16extrinsic allergic alveolitis30.3IL2RA, CXCR3, SFTPD, CCL3
17glomerulonephritis30.3CXCL9, CR1, PDGFB
18vasculitis30.3CD80, TNF
19leprosy30.3HLA-DRB1
20arthritis30.2NOD2, IL18, CXCL9, CXCL5, CXCR3, CD80
21leukemia30.2IL9, IL12B, IL2RA, CXCR3, CD80, LTA
22myocarditis30.2IL12RB1
23breast cancer30.2NOD2, CXCL9, CXCR3, CD80, CCL3
24lymphopenia30.2IL18, IL2RA, IFNG
25rheumatoid arthritis30.1NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL9
26pleurisy30.1IL2RA
27multiple sclerosis30.0IL9, IL12B, IL18, IL2RA, CXCL9, CXCR3
28dermatitis30.0NOD2, IL18, CXCL9, CXCR3, IFNG
29autoimmune thyroiditis30.0IL12B, IL2RA, CXCR3, CD80, IFNG
30aspergillosis30.0IFNG, SFTPD, CCL3
31gastritis30.0CXCL5, SFTPD, CCL3
32crohn's disease30.0NOD2, TNF
33bronchiolitis obliterans30.0CXCR3, PDGFB
34peritonitis30.0CR1, TNF
35respiratory failure30.0TNF, SFTPD
36bronchiolitis30.0CCL3
37tuberculoid leprosy30.0IL2RA, IFNG
38lepromatous leprosy30.0LTA, IFNG
39ulcerative colitis29.9NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL5
40hodgkin's lymphoma29.9IL9, IL2RA, CD80, LTA, CR1
41eosinophilia29.9IL9, IL18, IL2RA, IFNG
42diabetes mellitus29.9ACE, HLA-DRB1, TNF
43adenocarcinoma29.9CD80, PDGFB, SFTPD
44connective tissue disease29.9IL2RA, HLA-DRB1, TNF
45arthropathy29.9NOD2, TNF
46dilated cardiomyopathy29.9ACE, HLA-DRB1
47ankylosing spondylitis29.9TNF
48spondylitis29.9NOD2
49acute leukemia29.9IL9, CD80
50keratitis29.9CXCL9

Graphical network of the top 20 diseases related to Sarcoidosis:



Diseases related to sarcoidosis

Clinical Features for Sarcoidosis

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Drugs & Therapeutics for Sarcoidosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Sarcoidosis

Search NIH Clinical Center for Sarcoidosis

Search CenterWatch for Sarcoidosis

Genetic Tests for Sarcoidosis

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Anatomical Context for Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Sarcoidosis:

32
Lung, Lymph node, Testes, Skin, Heart, T cells, Liver, Eye, Monocytes, Thyroid, Breast, Endothelial, Bone, Kidney, Spinal cord, Myeloid, B cells, Spleen, Tonsil, Pancreas, Brain, Nk cells, Pineal, Testis, Prostate, Bone marrow, Colon, Skeletal muscle, Pituitary

Animal Models for Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1ACE, CCL3, SFTPD, IFNG, PDGFB, TNF
2MP:000539711.9LTA, TNF, PDGFB, IFNG, SFTPD, CCL3
3MP:000537611.7CCL3, SFTPD, IFNG, PDGFB, TNF, LTA
4MP:001076811.7TNF, PDGFB, IFNG, SFTPD, CCL3, LTA
5MP:000537811.4SFTPD, IFNG, PDGFB, TNF, LTA, IL2RA
6MP:000538411.4CCL3, IFNG, TNF, LTA, CD80, CXCR3
7MP:000538111.2CCL3, IFNG, TNF, IL2RA, IL18, IL12B
8MP:000538810.5SFTPD, LTA, CXCR3, IL12B

Publications for Sarcoidosis

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50PubMed
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Articles related to Sarcoidosis:

(show top 50)    (show all 2237)
idTitleAuthorsYear
1
Sarcoidosis in a chronic dialysis patient diagnosed by sarcoidosis-related hypercalcemia with no common systemic clinical manifestations: a case report and review of the literature. (24292755)
2013
2
Bronchial arterial embolisation for massive haemoptysis in cavitary sarcoidosis. (23355590)
2013
3
Cryptococcosis in sarcoidosis: cryptOsarc, a comparative study of 18 cases. (23515400)
2013
4
Response to Dr. Michael Hodgson's letter "Shortfalls in imputing sarcoidosis to occupational exposures". (23280609)
2013
5
sTREM-1 in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis, effect of smoking and inflammation. (24329508)
2013
6
An unusual case of sarcoidosis in an adult patient with sickle cell disease: management with methotrexate and low dose of steroid. (23335434)
2013
7
Nonsteroidal therapy of sarcoidosis. (23884295)
2013
8
Differential expression of microRNA and predicted targets in pulmonary sarcoidosis. (22209793)
2012
9
Chronic meningitis as the first presentation of sarcoidosis: an uncommon finding. (24250841)
2011
10
Atrial fibrillation as the initial clinical manifestation of cardiac sarcoidosis: a case report and review of the literature. (21252695)
2011
11
CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis. (19679608)
2010
12
Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literature. (19797887)
2010
13
Spontaneous recovery from progressive multifocal leukoencephalopathy in a patient with non-active sarcoidosis. (20599411)
2010
14
Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland. (20558894)
2010
15
Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2. (19910611)
2010
16
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
17
Practical issues and challenges in the diagnosis and treatment of pulmonary sarcoidosis. (17209662)
2007
18
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
19
Tumor necrosis factor receptors (TNFRs) on T lymphocytes and soluble TNFRs in different clinical courses of sarcoidosis. (16889950)
2007
20
Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis. (17975675)
2007
21
Comparative analysis of DR and DQ alleles occurrence in sarcoidosis and tuberculosis in the same ethnic group: preliminary study. (18038917)
2006
22
Role for CXCR6 and its ligand CXCL16 in the pathogenesis of T-cell alveolitis in sarcoidosis. (16100013)
2005
23
Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. (15459013)
2005
24
CD4+CD28-T cells are expanded in sarcoidosis. (15881275)
2005
25
Cardiac involvement in patients with pulmonary sarcoidosis assessed at two university medical centers in the Netherlands. (16002912)
2005
26
Cardiac sarcoidosis: two cases with autopsy findings. (16196153)
2004
27
Etanercept ameliorates sarcoidosis arthritis and skin disease. (12913948)
2003
28
Ventricular assist surprise: giant cell myocarditis or sarcoidosis? (14688728)
2003
29
Interleukin-18 expression in BAL cells of sarcoidosis patients is decreased in vivo but protein secretion is not impaired in vitro. (12735669)
2003
30
CC chemokine receptor 5 (CCR5) mRNA expression in pulmonary sarcoidosis. (11803051)
2002
31
Corticosteroid therapy increases HDL-cholesterol concentrations in patients with active sarcoidosis and hypoalphalipoproteinemia. (11983201)
2002
32
Transesophageal echocardiographic abnormalities in a case of cardiac sarcoidosis. (11337687)
2001
33
Granulomatous interstitial nephritis, hypercalcemia and rapidly progressive kidney failure secondary to sarcoidosis with exclusive renal involvement. (11799273)
2001
34
Increased levels of interleukin-18 in patients with pulmonary sarcoidosis. (11069843)
2000
35
Influence of serum amyloid A on the decrease of high density lipoprotein-cholesterol in active sarcoidosis. (10998479)
2000
36
Ketoconazole for the treatment of refractory hypercalcemic sarcoidosis. (11033844)
2000
37
Pulmonary sarcoidosis: calcified micronodular pattern simulating pulmonary alveolar microlithiasis. (10404510)
1999
38
Histologic diagnostic rate of cardiac sarcoidosis: evaluation of endomyocardial biopsies. (10426842)
1999
39
Bronchial responsiveness and angiotensin-converting enzyme gene polymorphism in sarcoidosis patients. (9726736)
1998
40
Pulmonary sarcoidosis: morphologic associations of airflow obstruction at thin-section CT. (9844661)
1998
41
Serum soluble adhesion molecules in patients with sarcoidosis]. (9493444)
1997
42
Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis. (7695007)
1995
43
Pulmonary sarcoidosis and corticosteroids. (8503575)
1993
44
Serum soluble IL-2 receptor level in patients with sarcoidosis]. (2067152)
1991
45
Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis. (2110187)
1990
46
Evaluation of the prognosis in sarcoidosis: remission as an issue of biological criteria and current cellular activities (ACE and alveolar lymphocytosis)]. (2157267)
1990
47
An autopsy case of cardiac sarcoidosis with refractory ventricular tachycardia. (2093706)
1990
48
Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)
1989
49
Sarcoidosis of the tentorium with cortical blindness. (2947914)
1985
50
Sarcoidosis presenting with pseudotumor cerebri and the nephrotic syndrome. (6533230)
1984

Genetic Variations for Sarcoidosis

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Expression for genes affiliated with Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sarcoidosis

Search GEO for disease gene expression data for Sarcoidosis.

Pathways for genes affiliated with Sarcoidosis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 12EMD Millipore
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Pathways related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.6TNF, LTA, CD80, CXCR3, CXCL5, CXCL9
2
Hide members
11.4IL12RB1, IL9, CCL3, PDGFB, LTA, CD80
3
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11.4IFNG, IL12RB1, TNF, HLA-DRB1, LTA, CD80
4
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11.4CCL3, PDGFB, LTA, CD80, CXCR3, CXCL5
5
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11.3CCL3, PDGFB, CD80, CXCR3, CXCL5, CXCL9
6
Hide members
11.2IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
711.1IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
8
Hide members
11.1IFNG, TNF, HLA-DRB1, LTA, IL2RA, IL18
9
Hide members
11.1IFNG, TNF, LTA, CD80, IL18, IL12B
10
Hide members
11.1IFNG, PDGFB, HLA-DRB1, CR1, CD80, IL2RA
11
Hide members
11.1CCL3, IFNG, HLA-DRB1, IL2RA, IL18, IL12B
12
Hide members
11.1CCL3, IFNG, TNF, CD80, CXCL9, IL12B
13
Development PDGF signaling via STATs and NF-kB
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11.1IFNG, PDGFB, TNF, CXCL9, IL18, IL12B
14
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11.1PDGFB, LTA, CD80, IL2RA, IL12B, IL9
1511.0IFNG, TNF, LTA, IL18, IL12B, IL9
16
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10.9NOD2, IL18, IL2RA, HLA-DRB1, IFNG
1710.9IFNG, IL2RA, IL12B, IL9, IL12RB1
1810.8IL2RA, CR1, HLA-DRB1, TNF
1910.8IL12B, IL18, CR1, TNF
2010.8TNF, LTA, CXCL5, NOD2
2110.8IL12B, IL18, TNF, IFNG
2210.8IFNG, TNF, IL18, IL12B
2310.8IFNG, HLA-DRB1, IL2RA, IL18
24
Hide members
10.8TNF, LTA, IL2RA, IL9
25
Hide members
10.8IFNG, PDGFB, TNF, LTA
2610.8IFNG, IL2RA, IL12B, IL12RB1
2710.8HLA-DRB1, IL2RA, IL12B, IL12RB1
28
Hide members
10.8IFNG, TNF, HLA-DRB1, CD80
29
Hide members
10.8IL9, LTA, TNF, PDGFB
30
Hide members
10.8IL2RA, TNF, IFNG, CCL3
31
Hide members
10.8CCL3, CXCR3, CXCL5, CXCL9
3210.8CCL3, CXCR3, CXCL5, CXCL9
33
Hide members
10.7LTA, TNF, IFNG
34
Hide members
10.7NOD2, IL18, TNF
3510.7IFNG, LTA, IL9
3610.7IFNG, TNF, IL2RA
37
Hide members
10.7IL2RA, TNF, IFNG
38
Immune response Bacterial infections in normal airways
10.7SFTPD, IFNG, TNF
3910.7IL12B, CXCL5, TNF
4010.7IL2RA, CD80, IFNG
4110.7IL18, IFNG, CCL3
4210.7HLA-DRB1, IL12B
4310.7IL18, CR1
4410.7IL2RA, PDGFB
4510.7IL18, CD80
4610.6IL12RB1, CD80

Compounds for genes affiliated with Sarcoidosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1nitric oxide44 11 2414.3ACE, NOD2, IL9, CCL3, SFTPD, IFNG
2tyrosine4411.9CXCL9, IL9, IL12RB1, IL2RA, IL18, CXCL5
3calcium44 49 11 2414.8CXCL9, CXCL5, CR1, CCL3, SFTPD, CD80
4il 104411.8NOD2, IL12B, IL18, IL2RA, CXCL9, CXCR3
5ionomycin4411.8CXCL9, IFNG, CCL3, TNF, LTA, CD80
6vegf4411.8IFNG, CCL3, PDGFB, TNF, CXCR3, CXCL5
7rantes4411.7CXCL5, CXCR3, LTA, TNF, IFNG, CCL3
8cyclosporin a44 28 5913.7PDGFB, IL2RA, CCL3, IFNG, TNF, CR1
9histamine44 28 2413.7IL9, CCL3, SFTPD, IFNG, CXCL9, CXCR3
10thymidine44 2412.7PDGFB, SFTPD, IL18, CCL3, TNF, IL9
11tarc4411.6CXCR3, CXCL5, CXCL9, IL18, IL9, CCL3
12infliximab44 49 1113.5CXCR3, IFNG, TNF, LTA, IL2RA, IL18
13ccl344 2812.5IL18, CXCL9, CXCL5, CXCR3, TNF, IFNG
14allergens4411.5IL9, IL18, SFTPD, HLA-DRB1, IFNG, CD80
15groalpha4411.4CXCL9, CXCL5, CXCR3, IL18, TNF, CCL3
16neopterin4411.4CCL3, TNF, LTA, IL2RA, IL18, IFNG
17prednisolone44 28 1113.4SFTPD, LTA, IL2RA, NOD2, CR1
18dexamethasone44 49 28 1114.4SFTPD, PDGFB, CXCL9, CD80, LTA
19il-124411.3IL18, TNF, IL12RB1, IFNG, IL12B
20tacrolimus44 49 1113.3IL2RA, CCL3, IFNG, PDGFB, CXCR3
21lipoteichoic acid4411.3TNF, LTA, IL12B, IL18, CCL3
22polyinosinic-polycytidylic acid4411.3IFNG, CCL3, IL12B, TNF, IL18
23oxygen44 2412.3CCL3, CR1, TNF, CD80, SFTPD
24etanercept44 49 1113.3IFNG, TNF, LTA, CXCR3, IL18
25poly(i-c)4411.3IL18, TNF, IFNG, IL12B, CCL3
26pd 98,0594411.3IL18, CXCR3, TNF, PDGFB, CCL3, IL12B
27ccl444 2812.3IL12B, CXCR3, CXCL5, CCL3, CXCL9
28ifn-alpha4411.3IL18, IL2RA, CXCL9, CXCR3, IFNG
29cycloheximide4411.2IL18, PDGFB, CR1, LTA
30tgf beta14411.2TNF, LTA, PDGFB, CCL3, IL18
31gold sodium thiomalate4411.2TNF, IFNG, HLA-DRB1, IL2RA
32serine4411.2IL18, LTA, CCL3, NOD2, TNF, IL9
33mannose4411.2NOD2, CD80, CR1, LTA, SFTPD
34natalizumab44 1112.2IFNG, TNF, IL18, IL2RA
35pentoxifylline44 1112.2LTA, IL18, IL12B
36fmlp4411.2CCL3, CXCL5, CXCR3, CR1
37imiquimod44 28 59 1114.2TNF, IFNG, IL18, IL12B
38okt34411.1LTA, TNF, IFNG, IL2RA
39endotoxin4411.1CXCL5, CXCR3
40peptidoglycan44 2812.1NOD2, IL12B, TNF, CCL3
41ribavirin44 49 1113.0CCL3, IFNG, IL18, CXCR3
42phosphatidylinositol4411.0CXCR3, IL2RA, SFTPD, IL12B, CD80, CR1
43gm-csf44 2811.9IFNG, TNF
44toxin-14410.9LTA, CCL3, TNF
45thalidomide44 49 59 1113.9IFNG, IL18, IL2RA, TNF
46tuberculin4410.9IL2RA, IL18, IFNG
47leukotriene b444 59 2412.8CXCL5, CR1, TNF, CCL3
48ivig4410.8IFNG
49pdtc4410.7IL18
505 aminosalicylic acid4410.4TNF, IL2RA, IL12B

GO Terms for genes affiliated with Sarcoidosis

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16Gene Ontology
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Cellular components related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3SFTPD, IFNG, PDGFB, TNF, CXCL5, CXCL9
2extracellular spaceGO:00561511.2TNF, PDGFB, IFNG, SFTPD, CCL3, LTA
3external side of plasma membraneGO:00989711.2ACE, IFNG, TNF, HLA-DRB1, CD80, CXCR3

Biological processes related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.4CCL3, IL18, CXCL9, CXCL5, LTA, CD80
2inflammatory responseGO:00695411.4CCL3, CXCL9, IL18, TNF, CXCR3, IL9
3immune responseGO:00695511.4CXCL5, IL2RA, CXCL9, IL9, HLA-DRB1, IL18
4negative regulation of growth of symbiont in hostGO:04413011.4NOD2, IL12B, TNF, LTA, IFNG
5positive regulation of tumor necrosis factor productionGO:03276011.4CCL3, IFNG, IL18, IL12B, NOD2
6positive regulation of interferon-gamma productionGO:03272911.4TNF, IL12B, LTA, IL18, IL12RB1
7positive regulation of activated T cell proliferationGO:04210411.3IL12B, IL18, IL2RA, IL12RB1
8cellular response to interferon-gammaGO:07134611.3IL18, IL12B, IL12RB1, CCL3
9positive regulation of ERK1 and ERK2 cascadeGO:07037411.2PDGFB, CCL3, TNF, NOD2
10chemotaxisGO:00693511.2CCL3, CXCR3, CXCL5, CXCL9
11response to hypoxiaGO:00166611.2IL18, TNF, PDGFB, LTA
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292511.2LTA, TNF, NOD2
13positive regulation of interleukin-17 productionGO:03274011.2NOD2, IL18, IL12B
14T-helper 1 type immune responseGO:04208811.2IL12B, HLA-DRB1, IL18
15positive regulation of osteoclast differentiationGO:04567211.2IFNG, IL12B, TNF
16positive regulation of interleukin-1 beta secretionGO:05071811.2CCL3, NOD2, IFNG
17positive regulation of NF-kappaB import into nucleusGO:04234611.2TNF, IL12B, IL18
18positive regulation of interleukin-12 productionGO:03273511.2IFNG, IL12B, NOD2
19lipopolysaccharide-mediated signaling pathwayGO:03166311.1IL18, TNF, CCL3
20negative regulation of T cell proliferationGO:04213011.1HLA-DRB1, SFTPD, IL2RA
21cellular response to organic cyclic compoundGO:07140711.1TNF, CCL3, IL18
22defense response to Gram-positive bacteriumGO:05083011.1TNF, NOD2, LTA
23humoral immune responseGO:00695911.1TNF, LTA, IFNG
24calcium-mediated signalingGO:01972211.1CXCR3, TNF, CCL3
25positive regulation of neuron apoptotic processGO:04352511.1IL18, TNF, CCL3
26positive regulation of inflammatory responseGO:05072911.1IL18, IL12B, CCL3
27positive regulation of vitamin D biosynthetic processGO:06055711.1TNF, IFNG
28positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.1LTA, TNF
29interferon-gamma biosynthetic processGO:04209511.1IL12B, IL18
30positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
31positive regulation of NK T cell proliferationGO:05114211.0IL18, IL12B
32positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL12RB1, IL12B
33MAPK cascadeGO:00016511.0CCL3, TNF, IL18
34T cell chemotaxisGO:01081811.0CCL3, CXCR3
35positive regulation of memory T cell differentiationGO:04338211.0IL12RB1, IL12B
36positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272511.0IL12B, IL18
37positive regulation of T-helper 17 type immune responseGO:200031810.9IL12B, IL12RB1
38positive regulation of natural killer cell proliferationGO:03281910.9IL18, IL12B
39positive regulation of tissue remodelingGO:03410510.9IL12B, IL18
40immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.9HLA-DRB1, NOD2
41positive regulation of smooth muscle cell apoptotic processGO:03439310.9IL12B, IFNG
42cell activationGO:00177510.9CCL3, TNF
43positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9NOD2, CD80, PDGFB
44response to drugGO:04249310.8TNF, IFNG, PDGFB, LTA
45epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.8PDGFB, TNF
46negative regulation of inflammatory response to antigenic stimulusGO:00286210.8NOD2, IL12B
47positive regulation of chemokine biosynthetic processGO:04508010.7IFNG, TNF
48negative regulation of interleukin-17 productionGO:03270010.7IL12B, IFNG
49positive regulation of interleukin-1 beta productionGO:03273110.6NOD2, IL18
50positive regulation of T-helper 1 type immune responseGO:00282710.4IL12B, IL12RB1

Molecular functions related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0IL9, IFNG, TNF, LTA, CXCL9, IL18
2interleukin-12 receptor bindingGO:00514310.7IL12RB1, IL12B
3chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3

Products for genes affiliated with Sarcoidosis

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Sources for Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet