MCID: SRC013
MIFTS: 75

Sarcoidosis malady

Rare diseases, Immune diseases, Neuronal diseases, Eye diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Endocrine diseases categories
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Summaries for Sarcoidosis

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NIH Rare Diseases:42 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. the granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. the course of the disease varies from person to person. it often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. for those who need treatment, anti-inflammatory medications can help. last updated: 3/30/2010

MalaCards based summary: Sarcoidosis, also known as lymphogranulomatosis, is related to thyroiditis and leprosy. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Canonical NF-kappaB pathway and Immune response MIF mediated glucocorticoid regulation. The drugs carmustine and chlorambucil and the compounds mycophenolate sodium and 5 aminosalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

MedlinePlus:33 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

Wikipedia:65 Sarcoidosis, also called sarcoid, is a disease involving abnormal collections of inflammatory cells... more...

Aliases & Classifications for Sarcoidosis

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Sarcoidosis, Aliases & Descriptions:

Name: Sarcoidosis 8 42 10 44 33 62
Lymphogranulomatosis 8 62
Boeck Sarcoid, Any Site 8
 
Schaumann's Disease 42
Sarcoid of Boeck 42


Classifications:



External Ids:

Disease Ontology8 DOID:11335
ICD9CM27 135
NCIt39 C34995
SNOMED-CT57 31541009, 154425004
MeSH34 D012507
ICD1025 D86, D86.9

Related Diseases for Sarcoidosis

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Diseases in the Sarcoidosis family:

Sarcoidosis 2 Sarcoidosis 1
Sarcoidosis 3

Diseases related to Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 504)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3HLA-DRB1
2leprosy31.2HLA-DRB1
3blau syndrome31.2TNF, NOD2
4asthma31.0TNF, IL12B
5spondylitis30.8NOD2
6lepromatous leprosy30.7LTA, IFNG
7pleurisy30.7IL2RA, TRB
8leishmaniasis30.7IFNG
9tuberculoid leprosy30.6IL2RA, IFNG
10pneumonia30.6SFTPD, CXCL5, TNF, CR1
11hepatitis30.5LTA, CR1, IL18
12familial mediterranean fever30.4NOD2, TNF
13diabetes mellitus30.4ACE, HLA-DRB1, TNF
14aspergillosis30.4IFNG, SFTPD
15extrinsic allergic alveolitis30.4IL2RA, SFTPD, CXCR3
16pars planitis30.3IL2RA, CXCR3
17psoriatic arthritis30.3NOD2, LTA
18connective tissue disease30.3HLA-DRB1, TNF, IL2RA
19nephritis30.2LTA, ACE, IL18, CR1, CXCR3
20visceral leishmaniasis30.2LTA, IFNG
21lymphopenia30.2IFNG, IL18, IL2RA
22skin disease30.2HLA-DRB1, IL2RA
23autoimmune thyroiditis30.1IL12B, IL2RA, CXCR3, IFNG
24interstitial lung disease30.1SFTPD, TNF
25hodgkin's lymphoma30.0IL9, TRB, IL2RA, CR1, LTA
26dermatitis30.0NOD2, CXCR3, IFNG, IL18
27hepatitis c30.0IL12B, IL18, IFNG, CXCR3, HLA-DRB1, CR1
28juvenile rheumatoid arthritis29.9IL2RA, TRB, LTA, HLA-DRB1, TNF
29chronic lymphocytic leukemia29.8CXCR3, CR1, IL2RA
30cystic fibrosis29.8CR1, IL9, SFTPD, TRB
31reticulosarcoma29.8TRB, CXCR3, IL9
32lung cancer29.8CR1, IL9, TRB, SFTPD, CXCR3
33uveitis29.8IFNG, CXCR3, TNF, ACE, IL2RA, IL9
34mycosis fungoides29.8IL2RA, CXCR3, TRB
35colitis29.8TNF, NOD2, IL12B, IFNG, IL18
36b-cell lymphomas29.8CXCR3, CR1, TRB
37tetanus29.8LTA, IL9, IL2RA, IFNG
38eosinophilia29.7IFNG, IL2RA, IL9, IL18
39hairy cell leukemia29.7CXCR3, IL2RA
40sjogren's syndrome29.7TRB, IL2RA, CXCR3, CR1
41idiopathic pulmonary fibrosis29.7IFNG, IL18, CXCL5, CXCR3, IL9, CR1
42pulmonary tuberculosis29.7HLA-DRB1, IFNG, IL2RA, IL12RB1, IL12B, IL18
43non-hodgkin lymphoma29.5IL9, TRB, IL12B, IL2RA, HLA-DRB1
44behcet's disease29.5LTA, IL2RA, IL18, TNF
45chronic obstructive pulmonary disease29.4IL9, CXCR3, TNF, SFTPD
46influenza29.2CR1, LTA, SFTPD, CXCR3, TRB, IFNG
47pulmonary sarcoidosis29.2TRB, LTA, IL9, IL12B, IL12RB1, IL2RA
48leukemia29.2LTA, CR1, HLA-DRB1, CXCR3, IL2RA, IL9
49graves' disease29.1IFNG, IL2RA, IL12B, CXCR3, TRB, LTA
50type 1 diabetes mellitus29.1CR1, TRB, LTA, IL12B, ACE, HLA-DRB1

Graphical network of the top 20 diseases related to Sarcoidosis:



Diseases related to sarcoidosis

Symptoms for Sarcoidosis

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Drugs & Therapeutics for Sarcoidosis

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Genetic Tests for Sarcoidosis

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Anatomical Context for Sarcoidosis

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MalaCards organs/tissues related to Sarcoidosis:

32
Lung, Lymph node, Testes, Skin, Heart, T cells, Liver, Eye, Monocytes, Thyroid, Breast, Neutrophil, Endothelial, Bone, Kidney, Spinal cord, Myeloid, B cells, Spleen, Brain, Pancreas, Tonsil, Bone marrow, Skeletal muscle, Colon, Prostate, Testis, Nk cells, Pineal, Pituitary

Animal Models for Sarcoidosis or affiliated genes

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MGI Mouse Phenotypes related to Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9IFNG, ACE, LTA, TRB, TNF
2MP:00020068.3TRB, ACE, CXCR3, TNF, IL12B, IFNG
3MP:00053887.9TNF, TRB, LTA, IL12B, IFNG, CXCR3
4MP:00053817.8TRB, NOD2, IL9, IL12B, IL2RA, IL18
5MP:00053857.5CXCR3, LTA, TNF, IFNG, ACE, IL18
6MP:00053787.2NOD2, LTA, TRB, ACE, IL2RA, IFNG
7MP:00053766.7ACE, IFNG, LTA, NOD2, IL9, IL12B
8MP:00107686.6TRB, LTA, NOD2, IL12B, IL2RA, IL18
9MP:00053975.9TNF, TRB, SFTPD, LTA, NOD2, IL9
10MP:00053875.9IL12RB1, IL12B, NOD2, LTA, TRB, IL2RA

Publications for Sarcoidosis

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Articles related to Sarcoidosis:

(show top 50)    (show all 2297)
idTitleAuthorsYear
1
Granulomatous dysimmune reactions (sarcoidosis, granuloma annulare, and others) on differently injured skin areas. (25160106)
2014
2
Cardiac sarcoidosis. (24969032)
2014
3
Dermoscopic features of sarcoidosis. (25404971)
2014
4
Sarcoidosis in a chronic dialysis patient diagnosed by sarcoidosis-related hypercalcemia with no common systemic clinical manifestations: a case report and review of the literature. (24292755)
2013
5
Granuloma Formation in Pulmonary Sarcoidosis. (24339826)
2013
6
Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)
2013
7
Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis. (23668840)
2013
8
Development of cutaneous sarcoidosis during treatment with tumour necrosis alpha factor antagonists. (23157794)
2012
9
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)
2012
10
Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. (22150367)
2012
11
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)
2012
12
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
13
Hypercalcemia and soft tissue calcification owing to sarcoidosis: the sunlight-cola connection. (20200968)
2010
14
Targeting the TNF-alpha pathway in sarcoidosis. (20001207)
2010
15
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
16
Clinical challenges and images in GI. Early peripancreatic and pulmonary sarcoidosis. (19013164)
2008
17
18F-FDG PET in sarcoidosis: an observational study in 12 patients treated with infliximab. (19382534)
2008
18
Inhibitors of tumor necrosis factor (TNF) in sarcoidosis: who, what, and how to use them. (19382527)
2008
19
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
20
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
21
Tumor necrosis factor inhibition in the treatment of refractory sarcoidosis: slaying the dragon? (17985412)
2007
22
CD14 genetics in sarcoidosis patients; who's in control? (18496988)
2007
23
Genetics of sarcoidosis: candidate genes and genome scans. (17202299)
2007
24
Complementary appearance of glucose and lipid metabolism in cardiac sarcoidosis. (16872698)
2007
25
Images in cardiology. Biventricular involvement in cardiac sarcoidosis. (16230435)
2005
26
Tumor necrosis factor inhibition as a novel treatment for refractory sarcoidosis. (16208666)
2005
27
Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)
2005
28
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. (15653992)
2005
29
Association between IFNA genotype and the risk of sarcoidosis. (15004750)
2004
30
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
31
Single-cell analysis: a novel approach to tumour necrosis factor-alpha synthesis and secretion in sarcoidosis. (12449172)
2002
32
Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis. (11790645)
2002
33
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)
2001
34
Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis. (10957763)
2000
35
Hyperbaric chamber-related decompression illness in a patient with asymptomatic pulmonary sarcoidosis. (10373052)
1999
36
The angiotensin-converting enzyme DD gene is associated with poor prognosis in Finnish sarcoidosis patients. (10362030)
1999
37
The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population. (10351956)
1999
38
Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. (10390413)
1999
39
Sarcoidosis in a patient with linear IgA disease. (10233655)
1999
40
Selection of T lymphocytes bearing limited TCR-Vbeta regions in the lung of hypersensitivity pneumonitis and sarcoidosis. (9032199)
1997
41
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
42
Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? (9305302)
1997
43
Glucocorticosteroids and pulmonary sarcoidosis. (8779121)
1996
44
Elevation of plasma-soluble tumour necrosis factor receptors (TNF-R) in sarcoidosis. (8625527)
1996
45
Endothelial cell damage in sarcoidosis and neurosarcoidosis: autoantibodies to endothelial cells. (7796836)
1995
46
Angiotensin-converting enzyme (ACE) polymorphism and serum ACE activities in sarcoidosis]. (8046841)
1994
47
Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. (8325116)
1993
48
Why perform high resolution computed tomography in pulmonary sarcoidosis? (8140309)
1993
49
Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)
1989
50
Nephrocalcinosis, hypercalcemia, sarcoidosis or primary hyperparathyroidism? (3983783)
1985

Variations for Sarcoidosis

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Expression for genes affiliated with Sarcoidosis

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Expression patterns in normal tissues for genes affiliated with Sarcoidosis

Search GEO for disease gene expression data for Sarcoidosis.

Pathways for genes affiliated with Sarcoidosis

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Pathways related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOD2, TNF
29.9IFNG, TNF
3
Show member pathways
9.7TNF, LTA, IL12B
49.7IL18, IFNG
5
Show member pathways
9.7TNF, LTA, IFNG
6
Show member pathways
9.7TNF, IFNG, LTA
79.7IL18, TNF
89.6TNF, IL12B, IFNG
99.6IL9, IFNG, LTA
109.6IL12B, CXCL5, TNF
11
Show member pathways
9.5IL12B, IFNG, IL12RB1
12
Show member pathways
9.5IFNG, TNF, IL2RA
13
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.5TNF, IL2RA, IFNG
14
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5IL2RA, TNF, IFNG
15
Show member pathways
9.4IFNG, IL18, NOD2
16
Show member pathways
9.4NOD2, TNF, IL18
179.4NOD2, CXCL5, LTA, TNF
18
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4IFNG, TNF, IL12B, ACE
19
Show member pathways
9.4NOD2, IL18, IL2RA
209.3CR1, IL2RA, TNF, HLA-DRB1
219.3TNF, LTA, HLA-DRB1, IL2RA
22
Show member pathways
9.3TNF, HLA-DRB1, IFNG, IL2RA
23
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.2LTA, TNF, IL9, IL2RA
249.2CR1, TNF, IL18, IL12B
259.2IL18, TNF, IFNG, CR1
269.2IL12B, IL12RB1, IL2RA, IFNG
279.1IFNG, TNF, IL12B, IL18
289.1IL18, IFNG, IL12B, TNF
299.0HLA-DRB1, IL18, IL2RA, IFNG
30
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0TNF, IFNG, IL9, TRB
318.8TRB, IL12B, IFNG, TNF, HLA-DRB1
32
Show member pathways
Type III interferon signaling37
8.8IFNG, IL12B, IL9, IL2RA, IL12RB1
33
Show member pathways
8.8HLA-DRB1, IL2RA, IFNG, IL18, NOD2
348.8CXCL5, TNF, IFNG, IL18, HLA-DRB1
35
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.7IL12B, IL12RB1, IL18, IFNG, TNF
36
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7LTA, TNF, SFTPD, TRB, IFNG
37
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6IL12RB1, TRB, HLA-DRB1, IL2RA, IL12B
388.6IL12B, IFNG, TNF, LTA, IL9, IL18
39
Show member pathways
IL27-mediated signaling events37
8.5TNF, LTA, IL12B, IL12RB1, IL18, IFNG
408.4IL18, HLA-DRB1, TNF, IFNG, IL12B, CR1
41
Show member pathways
8.3HLA-DRB1, LTA, IFNG, IL18, IL2RA, IL12B
42
Show member pathways
8.0HLA-DRB1, TNF, IFNG, IL12RB1, IL12B, IL18
43
Show member pathways
Immune response IL 12 induced IFN gamma production60
7.8IL12RB1, IL18, HLA-DRB1, TRB, IL2RA, IL12B
44
Show member pathways
7.8TNF, IL18, IFNG, LTA, IL9, IL12B
45
Show member pathways
7.5IL9, IFNG, IL18, IL2RA, IL12RB1, IL12B
46
Show member pathways
7.1LTA, IL2RA, IL18, CXCL5, CXCR3, IL12B
47
Show member pathways
7.1LTA, TNF, CXCR3, CXCL5, IL18, IL12RB1
48
Show member pathways
7.1CXCR3, CXCL5, IL9, IL12RB1, IL18, IL2RA
49
Show member pathways
6.8LTA, IL9, IL12RB1, IL2RA, IL18, IFNG

Compounds for genes affiliated with Sarcoidosis

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Compounds related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1mycophenolate sodium4410.0IL2RA, CR1
25 aminosalicylic acid449.8TNF, IL2RA, IL12B
3polymyxin b449.8CR1, TNF, IFNG
4okt3449.7IFNG, LTA, TNF, IL2RA
5gold sodium thiomalate449.7IL2RA, TNF, HLA-DRB1, IFNG
6ivig449.6LTA, IL2RA, IFNG, TNF
7tuberculin449.6IL2RA, IFNG, IL18
8indoleamine449.6IFNG, TNF, IL18
9lipoteichoic acid449.5TNF, LTA, IL12B, IL18
10imiquimod44 61 28 1112.5TNF, IFNG, IL18, IL12B
11polyinosinic-polycytidylic acid449.5IL12B, IFNG, IL18, TNF
12poly(i-c)449.5IL12B, IL18, TNF, IFNG
13natalizumab44 1110.4TNF, IL2RA, IL18, IFNG
14con a449.3IFNG, IL2RA, IL18
15thalidomide44 50 61 1112.3IL18, TNF, IL2RA, IFNG
16atorvastatin44 50 28 24 1113.2IL18, IL2RA, ACE, TNF
17herbimycin a44 6110.2IL2RA, TNF, IFNG, LTA
18mycophenolate mofetil44 50 1111.2IL18, LTA, IL2RA, TNF, IFNG
19neopterin449.2IFNG, LTA, IL2RA, IL18, TNF
20fmlp449.1LTA, CXCL5, TNF, CXCR3, CR1
21il-12449.1IFNG, IL18, IL12B, IL12RB1, TNF
22groalpha449.1TNF, IL18, CXCL5, CXCR3
23gm-csf44 2810.1IL18, IFNG, TNF
24indomethacin44 28 61 1112.0TNF, IL2RA, LTA, IFNG, IL18
25ifn-alpha449.0IFNG, IL18, IL2RA, CXCR3
26cycloheximide449.0LTA, TNF, IFNG, IL12B, IL18, CR1
27pentoxifylline44 1110.0LTA, IL12B, IL2RA, IL18, IFNG, TNF
28etanercept44 50 1110.9LTA, CXCR3, IFNG, IL18, TNF
29ccl344 289.8TNF, CXCR3, CXCL5, IFNG, IL18
30tacrolimus44 50 1110.5IFNG, CXCR3, IL2RA, TNF, IL18, NOD2
31tarc448.5IFNG, IL18, CXCL5, CXCR3, IL9, TNF
32oligonucleotide448.5SFTPD, HLA-DRB1, IL9, LTA, TRB, CXCL5
33ionomycin448.5LTA, IL9, IL12RB1, IL2RA, IFNG, IL18
34cyclosporin a44 28 6110.4TNF, TRB, LTA, CR1, IL2RA, IL18
35allergens448.4IL9, HLA-DRB1, SFTPD, IL18, CXCR3, IFNG
36infliximab44 50 1110.4LTA, NOD2, IFNG, TNF, IL18, IL2RA
37prednisolone44 28 1110.3IL2RA, TNF, SFTPD, IFNG, IL18, CR1
38rantes448.2CXCR3, IFNG, IL2RA, IL12B, IL9, IL18
39oxygen44 249.2CXCR3, TNF, IL18, SFTPD, CR1, NOD2
40vegf448.1TNF, LTA, CXCR3, CXCL5, IL2RA, IL18
41lipid448.1TNF, SFTPD, IL18, IL12B, ACE, LTA
42il 10448.1NOD2, IL12B, IL2RA, IL18, IFNG, LTA
43pge2448.0IL2RA, IL12B, LTA, IFNG, CXCL5, CXCR3
44histamine44 28 2410.0IL18, IL9, IL2RA, IFNG, CXCR3, TNF
45thymidine44 249.0CXCR3, IFNG, IL18, IL9, SFTPD, TNF
46endotoxin447.5TNF, SFTPD, LTA, NOD2, CXCR3, CXCL5
47dexamethasone44 50 28 1110.4IL2RA, IL12RB1, LTA, CXCR3, IL18, IFNG
48calcium44 50 24 1110.2CXCL5, SFTPD, CXCR3, CR1, ACE, IL18
49tyrosine447.1IL2RA, IL12RB1, IL9, TRB, CR1, LTA
50nitric oxide44 24 118.9IL18, CXCR3, TNF, IL12B, SFTPD, IL9

GO Terms for genes affiliated with Sarcoidosis

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Cellular components related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7ACE, IFNG, CXCL5, SFTPD, IL18
2external side of plasma membraneGO:0098977.9HLA-DRB1, IL12RB1, IL2RA, ACE, IFNG, CXCR3
3extracellular spaceGO:0056157.2SFTPD, TNF, CXCL5, IFNG, ACE, IL18

Biological processes related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.4LTA, TNF
2negative regulation of inflammatory response to antigenic stimulusGO:00286210.4IL12B, NOD2
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.3HLA-DRB1, NOD2
4positive regulation of vitamin D biosynthetic processGO:06055710.3IFNG, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, TNF
6positive regulation of smooth muscle cell apoptotic processGO:03439310.3IFNG, IL12B
7negative regulation of interleukin-17 productionGO:03270010.3IL12B, IFNG
8detection of bacteriumGO:01604510.3HLA-DRB1, NOD2
9positive regulation of chemokine biosynthetic processGO:04508010.2IFNG, TNF
10positive regulation of T-helper 17 cell lineage commitmentGO:200033010.2IL12B, IL12RB1
11positive regulation of T-helper 17 type immune responseGO:200031810.2IL12B, IL12RB1
12positive regulation of memory T cell differentiationGO:04338210.2IL12B, IL12RB1
13positive regulation of membrane protein ectodomain proteolysisGO:05104410.2TNF, IFNG
14defense response to protozoanGO:04283210.2IL12B, IFNG
15positive regulation of interleukin-10 productionGO:03273310.2IL12B, NOD2
16positive regulation of interleukin-1 beta secretionGO:05071810.2NOD2, IFNG
17positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.2TNF, NOD2, LTA
18positive regulation of interleukin-12 productionGO:03273510.1IL12B, IFNG, NOD2
19defense response to Gram-positive bacteriumGO:05083010.1NOD2, TNF, LTA
20positive regulation of T-helper 1 type immune responseGO:00282710.1IL12RB1, IL12B
21interferon-gamma biosynthetic processGO:04209510.1IL12B, IL18
22positive regulation of tumor necrosis factor productionGO:03276010.1IFNG, IL12B, NOD2
23inflammatory response to antigenic stimulusGO:00243710.1IL2RA, HLA-DRB1
24positive regulation of NK T cell proliferationGO:05114210.1IL12B, IL18
25positive regulation of tissue remodelingGO:03410510.1IL18, IL12B
26positive regulation of defense response to virus by hostGO:00223010.1IL12B, IL12RB1
27positive regulation of natural killer cell proliferationGO:03281910.1IL18, IL12B
28positive regulation of osteoclast differentiationGO:04567210.1IFNG, IL12B, TNF
29positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.1IL18, IL12B
30humoral immune responseGO:00695910.1LTA, TNF, IFNG
31protein import into nucleus, translocationGO:00006010.0IFNG, TNF
32positive regulation of T cell mediated cytotoxicityGO:00191610.0IL12B, IL12RB1
33natural killer cell activationGO:0301019.9IL12B, IL18
34negative regulation of smooth muscle cell proliferationGO:0486629.9IFNG, IL12B
35positive regulation of interleukin-17 productionGO:0327409.9IL18, NOD2, IL12B
36negative regulation of interferon-gamma productionGO:0326899.9NOD2, HLA-DRB1
37T-helper 1 type immune responseGO:0420889.9IL18, IL12B, HLA-DRB1
38positive regulation of phagocytosisGO:0507669.9NOD2, SFTPD
39positive regulation of NF-kappaB import into nucleusGO:0423469.8IL12B, IL18, TNF
40defense response to bacteriumGO:0427429.8NOD2, SFTPD, IFNG
41cellular response to interferon-gammaGO:0713469.8IL12B, IL12RB1
42negative regulation of T cell proliferationGO:0421309.8IL2RA, HLA-DRB1, SFTPD
43negative regulation of growth of symbiont in hostGO:0441309.6LTA, NOD2, IL12B, IFNG, TNF
44positive regulation of activated T cell proliferationGO:0421049.4IL12B, IL2RA, IL12RB1, IL18
45lipopolysaccharide-mediated signaling pathwayGO:0316639.4TNF, IL18
46cell surface receptor signaling pathwayGO:0071669.3CXCR3, IL2RA, IFNG
47positive regulation of interferon-gamma productionGO:0327299.2TNF, LTA, IL12B, IL12RB1, IL18
48immune responseGO:0069559.1CXCL5, HLA-DRB1, IL9, IL2RA, IL18
49apoptotic processGO:0069159.0CXCR3, IFNG, IL2RA, LTA, TNF
50inflammatory responseGO:0069549.0IL9, IL18, CXCR3, TNF

Molecular functions related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00516410.0LTA, TNF
2interleukin-12 receptor bindingGO:0051439.7IL12RB1, IL12B
3cytokine receptor activityGO:0048969.5IL12B, IL12RB1
4cytokine activityGO:0051258.6IFNG, LTA, IL9, IL12B, IL18, TNF

Products for genes affiliated with Sarcoidosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet