MCID: SRC013
MIFTS: 69

Sarcoidosis malady

Immune diseases category

Summaries for Sarcoidosis

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42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. the granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. the course of the disease varies from person to person. it often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. for those who need treatment, anti-inflammatory medications can help. last updated: 3/30/2010

MalaCards: Sarcoidosis, also known as boeck sarcoid, any site, is related to pulmonary sarcoidosis and tuberculosis. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Akt Signaling and PAK Pathway. The compounds nitric oxide and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are immune system and hematopoietic system.

MedlinePlus:33 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

Wikipedia:63 Sarcoidosis (from sarc meaning \"flesh\", -oid, \"like\", and -osis, \"diseased or abnormal... more...

Aliases & Classifications for Sarcoidosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

sarcoidosis 8 42 10 44 33 60
boeck sarcoid, any site 8
lymphogranulomatosis 8
schaumann's disease 42
sarcoid of boeck 42


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Disease Ontology8 DOID:11335
NCIt39 C34995
MeSH34 D012507
SNOMED-CT56 31541009, 154425004
ICD9CM27 135
ICD1025 D86, D86.9

Related Diseases for Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases in the Sarcoidosis 1 family:

sarcoidosis Sarcoidosis 2
Sarcoidosis 3

Diseases related to Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 493)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary sarcoidosis31.7ACE, IL12RB1, IL9, IL12B, IL18, IL2RA
2tuberculosis30.8NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL9
3pulmonary fibrosis30.7CXCR3, PDGFB, SFTPD, CCL3
4idiopathic pulmonary fibrosis30.7IL9, IL18, CXCL9, CXCL5, CXCR3, CR1
5hepatitis30.6CR1, HLA-DRB1, PDGFB
6hypercalcemia30.6LTA, CCL3
7hypertension30.5ACE
8pulmonary tuberculosis30.5IL12RB1, IL12B, IL18, IL2RA, CD80, HLA-DRB1
9uveitis30.4ACE, NOD2, IL9, IL2RA, CXCL9, CXCR3
10pneumonia30.4CXCL5, CR1, TNF, SFTPD, CCL3
11lupus erythematosus30.4IL18
12hepatitis c30.4IL12B, IL18, CXCR3, CR1, HLA-DRB1, TNF
13thyroiditis30.4HLA-DRB1
14asthma30.3IL12B, TNF
15systemic lupus erythematosus30.3NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCR3
16extrinsic allergic alveolitis30.3IL2RA, CXCR3, SFTPD, CCL3
17glomerulonephritis30.3CXCL9, CR1, PDGFB
18vasculitis30.3CD80, TNF
19leprosy30.3HLA-DRB1
20arthritis30.2NOD2, IL18, CXCL9, CXCL5, CXCR3, CD80
21leukemia30.2IL9, IL12B, IL2RA, CXCR3, CD80, LTA
22myocarditis30.2IL12RB1
23breast cancer30.2NOD2, CXCL9, CXCR3, CD80, CCL3
24lymphopenia30.2IL18, IL2RA, IFNG
25rheumatoid arthritis30.1NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL9
26pleurisy30.1IL2RA
27multiple sclerosis30.0IL9, IL12B, IL18, IL2RA, CXCL9, CXCR3
28dermatitis30.0NOD2, IL18, CXCL9, CXCR3, IFNG
29autoimmune thyroiditis30.0IL12B, IL2RA, CXCR3, CD80, IFNG
30aspergillosis30.0IFNG, SFTPD, CCL3
31gastritis30.0CXCL5, SFTPD, CCL3
32crohn's disease30.0NOD2, TNF
33bronchiolitis obliterans30.0CXCR3, PDGFB
34peritonitis30.0CR1, TNF
35respiratory failure30.0TNF, SFTPD
36bronchiolitis30.0CCL3
37tuberculoid leprosy30.0IL2RA, IFNG
38lepromatous leprosy30.0LTA, IFNG
39ulcerative colitis29.9NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL5
40hodgkin's lymphoma29.9IL9, IL2RA, CD80, LTA, CR1
41eosinophilia29.9IL9, IL18, IL2RA, IFNG
42diabetes mellitus29.9ACE, HLA-DRB1, TNF
43adenocarcinoma29.9CD80, PDGFB, SFTPD
44connective tissue disease29.9IL2RA, HLA-DRB1, TNF
45arthropathy29.9NOD2, TNF
46dilated cardiomyopathy29.9ACE, HLA-DRB1
47ankylosing spondylitis29.9TNF
48spondylitis29.9NOD2
49acute leukemia29.9IL9, CD80
50keratitis29.9CXCL9

Graphical network of the top 20 diseases related to Sarcoidosis:



Diseases related to sarcoidosis

Clinical Features for Sarcoidosis

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Drugs & Therapeutics for Sarcoidosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Sarcoidosis

Search NIH Clinical Center for Sarcoidosis

Search CenterWatch for Sarcoidosis

Genetic Tests for Sarcoidosis

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Anatomical Context for Sarcoidosis

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32MalaCards
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MalaCards organs/tissues related to Sarcoidosis:

32
Lung, Lymph node, Testes, Skin, Heart, T cells, Liver, Eye, Monocytes, Thyroid, Breast, Endothelial, Bone, Kidney, Spinal cord, Myeloid, B cells, Spleen, Brain, Tonsil, Pancreas, Testis, Nk cells, Prostate, Colon, Pituitary, Bone marrow, Skeletal muscle, Pineal

Animal Models for Sarcoidosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sarcoidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.1ACE, CCL3, SFTPD, IFNG, PDGFB, TNF
2MP:000539711.9LTA, TNF, PDGFB, IFNG, SFTPD, CCL3
3MP:000537611.7CCL3, SFTPD, IFNG, PDGFB, TNF, LTA
4MP:001076811.7TNF, PDGFB, IFNG, SFTPD, CCL3, LTA
5MP:000537811.4SFTPD, IFNG, PDGFB, TNF, LTA, IL2RA
6MP:000538411.4CCL3, IFNG, TNF, LTA, CD80, CXCR3
7MP:000538111.2CCL3, IFNG, TNF, IL2RA, IL18, IL12B
8MP:000538810.5SFTPD, LTA, CXCR3, IL12B

Publications for Sarcoidosis

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50PubMed
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Articles related to Sarcoidosis:

(show top 50)    (show all 2237)
idTitleAuthorsYear
1
Relationship between Parenchymal Involvement and Obstructive Sleep Apnea in Subjects with Sarcoidosis. (24405843)
2014
2
Cutaneous sarcoidosis and infliximab: evidence for efficacy in refractory disease. (23651297)
2013
3
Multinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosis: integrating systematic literature research and expert opinion of sarcoidologists worldwide. (23880702)
2013
4
Is sarcoidosis a thrombophilic disorder? (23604432)
2013
5
Prevalence of Cardiac Sarcoidosis in Patients Presenting with Monomorphic Ventricular Tachycardia. (24102263)
2013
6
Primary peritoneal sarcoidosis causing an omental cake. (23317586)
2013
7
Bloody pleural effusion--a rare manifestation of sarcoidosis. (23728558)
2013
8
Comparison of cutaneous sarcoidosis with systemic sarcoidosis: a retrospective analysis. (24427359)
2013
9
Echoic features of lymph nodes with sarcoidosis determined by endobronchial ultrasound. (23812194)
2013
10
Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy. (21937273)
2012
11
HLA-DRB1 allele frequencies and C4 copy number variation in Finnish sarcoidosis patients and associations with disease prognosis. (22074998)
2012
12
A case of pulmonary sarcoidosis preceding polycythemia vera with literature review. (20229031)
2012
13
Association of interleukin 23 receptor gene with sarcoidosis. (21846945)
2011
14
TNF-alpha and TNF-beta gene polymorphisms in Polish patients with sarcoidosis. Connection with the susceptibility and prognosis. (21319595)
2010
15
Unusual cardiovascular manifestations of sarcoidosis, a report of three cases: coronary artery aneurysm with myocardial infarction, symptomatic mitral valvular disease, and sudden death from ruptured splenic artery. (19502084)
2010
16
Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis. (20461686)
2010
17
Angiotensin II receptor type 1 1166 A/C and angiotensin converting enzyme I/D gene polymorphisms in a Dutch sarcoidosis cohort. (21319597)
2010
18
The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. (19200680)
2010
19
Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome. (18437252)
2008
20
Successful surgical treatment for dilated cardiomyopathy with cardiac sarcoidosis. (17643597)
2007
21
Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients. (16446531)
2006
22
Systemic sclerosis-polymyositis overlap syndrome accompanied by autoimmune hepatitis and sarcoidosis of mediastinal lymphnodes. (16405625)
2006
23
Sarcoidosis and granuloma genes: a family-based study in African-Americans. (15332393)
2004
24
Identification of cardiac sarcoidosis with (13)N-NH(3)/(18)F-FDG PET. (12843216)
2003
25
Heart transplantation for undiagnosed cardiac sarcoidosis. (12062749)
2002
26
Clinical significance of serum KL-6 in pulmonary sarcoidosis]. (11855079)
2001
27
Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population. (11844139)
2001
28
Development of an enzyme-linked immunosorbent assay for Clara cell 10-kDa protein: in pursuit of clinical significance of sera in patients with asthma and sarcoidosis. (11193763)
2000
29
The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population. (10351956)
1999
30
Lung transplantation for end-stage pulmonary sarcoidosis. (10207947)
1999
31
Unusual case of disseminated sarcoidosis with prominent gastrointestinal symptoms]. (9987484)
1999
32
A case of primary SjAPgren's syndrome presenting with aseptic meningoencephalitis associated with sarcoidosis]. (10363271)
1999
33
Hepatopulmonary syndrome associated with sarcoidosis of the liver: case report. (9879271)
1998
34
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
35
Incidence of cardiac sarcoidosis in Japanese patients with high-degree atrioventricular block. (9327691)
1997
36
Doppler echocardiographic detection of left ventricular diastolic dysfunction in patients with pulmonary sarcoidosis. (8549220)
1996
37
Pentoxifylline inhibits secretion of O2- and TNF-alpha by alveolar macrophages in patients with sarcoidosis]. (7615305)
1995
38
Angiotensin-converting enzyme (ACE) in sarcoidosis, tuberculosis, silicosis, and coal mining workers]. (7734665)
1994
39
Soluble and cellular markers of T cell activation in patients with pulmonary sarcoidosis. (8396372)
1993
40
Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. (1541144)
1992
41
The usefulness of serum angiotensin-converting enzyme test in the diagnosis of sarcoidosis. (1668804)
1991
42
Activity of angiotensin I converting enzyme in serum and bronchoalveolar lavage fluid of patients with sarcoidosis and lung neoplasms]. (1668848)
1991
43
Relationship between inflammatory processes and gas exchanges in pulmonary sarcoidosis. (2670466)
1989
44
Cardiac sarcoidosis: two cases with ventricular tachycardia and review of cardiac involvement in sarcoid. (15227374)
1986
45
Nephrocalcinosis, hypercalcemia, sarcoidosis or primary hyperparathyroidism? (3983783)
1985
46
Rapid effect of prednisolone on serum 1,25-dihydroxycholecalciferol levels in hypercalcemic sarcoidosis. (3841460)
1985
47
Granulomas in sympathetic ophthalmia and sarcoidosis. Immunohistochemical study. (2579628)
1985
48
Sarcoidosis and membranous glomerulonephritis: a significant association. (6803947)
1982
49
Probable myeloblastic leukemoid reaction with disseminated sarcoidosis. (270228)
1977
50
Studies in serum electrolytes; the calcium-binding property of the serum proteins (multiple myeloma, lymphogranuloma venereum and sarcoidosis. (18897629)
1948

Genetic Variations for Sarcoidosis

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Expression for genes affiliated with Sarcoidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sarcoidosis

Search GEO for disease gene expression data for Sarcoidosis.

Pathways for genes affiliated with Sarcoidosis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 12EMD Millipore
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Pathways related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6TNF, LTA, CD80, CXCR3, CXCL5, CXCL9
2
Hide members
11.4IL12RB1, IL9, CCL3, PDGFB, LTA, CD80
3
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11.4IFNG, IL12RB1, TNF, HLA-DRB1, LTA, CD80
4
Hide members
11.4CCL3, PDGFB, LTA, CD80, CXCR3, CXCL5
5
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11.3CCL3, PDGFB, CD80, CXCR3, CXCL5, CXCL9
6
Hide members
11.2IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
711.1IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
8
Hide members
11.1IFNG, TNF, HLA-DRB1, LTA, IL2RA, IL18
9
Hide members
11.1IFNG, TNF, LTA, CD80, IL18, IL12B
10
Hide members
11.1IFNG, PDGFB, HLA-DRB1, CR1, CD80, IL2RA
11
Hide members
11.1CCL3, IFNG, HLA-DRB1, IL2RA, IL18, IL12B
12
Hide members
11.1CCL3, IFNG, TNF, CD80, CXCL9, IL12B
13
Development PDGF signaling via STATs and NF-kB
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11.1IFNG, PDGFB, TNF, CXCL9, IL18, IL12B
14
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11.1PDGFB, LTA, CD80, IL2RA, IL12B, IL9
1511.0IFNG, TNF, LTA, IL18, IL12B, IL9
16
Hide members
10.9NOD2, IL18, IL2RA, HLA-DRB1, IFNG
1710.9IFNG, IL2RA, IL12B, IL9, IL12RB1
1810.8IL2RA, CR1, HLA-DRB1, TNF
1910.8IL12B, IL18, CR1, TNF
2010.8TNF, LTA, CXCL5, NOD2
2110.8IL12B, IL18, TNF, IFNG
2210.8IFNG, TNF, IL18, IL12B
2310.8IFNG, HLA-DRB1, IL2RA, IL18
24
Hide members
10.8TNF, LTA, IL2RA, IL9
25
Hide members
10.8IFNG, PDGFB, TNF, LTA
2610.8IFNG, IL2RA, IL12B, IL12RB1
2710.8HLA-DRB1, IL2RA, IL12B, IL12RB1
28
Hide members
10.8IFNG, TNF, HLA-DRB1, CD80
29
Hide members
10.8IL9, LTA, TNF, PDGFB
30
Hide members
10.8IL2RA, TNF, IFNG, CCL3
31
Hide members
10.8CCL3, CXCR3, CXCL5, CXCL9
3210.8CCL3, CXCR3, CXCL5, CXCL9
33
Hide members
10.7LTA, TNF, IFNG
34
Hide members
10.7NOD2, IL18, TNF
3510.7IFNG, LTA, IL9
3610.7IFNG, TNF, IL2RA
37
Hide members
10.7IL2RA, TNF, IFNG
38
Immune response Bacterial infections in normal airways
10.7SFTPD, IFNG, TNF
3910.7IL12B, CXCL5, TNF
4010.7IL2RA, CD80, IFNG
4110.7IL18, IFNG, CCL3
4210.7HLA-DRB1, IL12B
4310.7IL18, CR1
4410.7IL2RA, PDGFB
4510.7IL18, CD80
4610.6IL12RB1, CD80

Compounds for genes affiliated with Sarcoidosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1nitric oxide44 11 2414.3ACE, SFTPD, IFNG, PDGFB, TNF, CR1
2tyrosine4411.9PDGFB, HLA-DRB1, CR1, LTA, CD80, CXCR3
3calcium44 49 11 2414.8CCL3, SFTPD, CR1, LTA, CD80, CXCR3
4il 104411.8CCL3, IFNG, TNF, LTA, CXCR3, CXCL9
5ionomycin4411.8CD80, CXCL9, IL2RA, IL18, IL9, IL12RB1
6vegf4411.8CCL3, IFNG, PDGFB, TNF, LTA, CXCR3
7rantes4411.7CCL3, IFNG, TNF, LTA, CXCR3, CXCL5
8cyclosporin a44 28 5913.7CCL3, IFNG, PDGFB, TNF, CR1, LTA
9histamine44 28 2413.7CCL3, SFTPD, IFNG, TNF, CXCR3, CXCL9
10thymidine44 2412.7CCL3, SFTPD, IFNG, PDGFB, TNF, CXCR3
11tarc4411.6CCL3, IFNG, TNF, CXCR3, CXCL5, CXCL9
12infliximab44 49 1113.5IFNG, TNF, LTA, CXCR3, IL2RA, IL18
13ccl344 2812.5CCL3, IFNG, TNF, CXCR3, CXCL5, CXCL9
14allergens4411.5SFTPD, IFNG, HLA-DRB1, CD80, CXCR3, IL18
15groalpha4411.4CCL3, TNF, CXCR3, CXCL5, CXCL9, IL18
16neopterin4411.4CCL3, IFNG, TNF, LTA, IL2RA, IL18
17prednisolone44 28 1113.4SFTPD, CR1, LTA, IL2RA, NOD2
18dexamethasone44 49 28 1114.4CXCL9, CD80, LTA, PDGFB, SFTPD
19il-124411.3IFNG, TNF, IL18, IL12B, IL12RB1
20tacrolimus44 49 1113.3CCL3, IFNG, PDGFB, CXCR3, IL2RA
21lipoteichoic acid4411.3CCL3, TNF, LTA, IL18, IL12B
22polyinosinic-polycytidylic acid4411.3IL12B, IL18, TNF, IFNG, CCL3
23oxygen44 2412.3CCL3, SFTPD, TNF, CR1, CD80
24etanercept44 49 1113.3IFNG, TNF, LTA, CXCR3, IL18
25poly(i-c)4411.3IL12B, IL18, TNF, IFNG, CCL3
26pd 98,0594411.3CCL3, PDGFB, TNF, CXCR3, IL18, IL12B
27ccl444 2812.3IL12B, CXCL9, CXCL5, CXCR3, CCL3
28ifn-alpha4411.3IFNG, CXCR3, CXCL9, IL2RA, IL18
29cycloheximide4411.2IL18, LTA, CR1, PDGFB
30tgf beta14411.2IL18, LTA, TNF, PDGFB, CCL3
31gold sodium thiomalate4411.2IFNG, TNF, HLA-DRB1, IL2RA
32serine4411.2CCL3, PDGFB, TNF, LTA, CXCR3, IL18
33mannose4411.2SFTPD, CR1, LTA, CD80, NOD2
34natalizumab44 1112.2IL18, IL2RA, TNF, IFNG
35pentoxifylline44 1112.2LTA, IL18, IL12B
36fmlp4411.2CCL3, CR1, CXCR3, CXCL5
37imiquimod44 28 59 1114.2IFNG, TNF, IL18, IL12B
38okt34411.1IL2RA, LTA, TNF, IFNG
39endotoxin4411.1CXCL5, CXCR3
40peptidoglycan44 2812.1NOD2, IL12B, TNF, CCL3
41ribavirin44 49 1113.0CCL3, IFNG, CXCR3, IL18
42phosphatidylinositol4411.0SFTPD, CR1, CD80, CXCR3, CXCL9, IL2RA
43gm-csf44 2811.9IFNG, TNF
44toxin-14410.9LTA, TNF, CCL3
45thalidomide44 49 59 1113.9IL18, IL2RA, TNF, IFNG
46tuberculin4410.9IL18, IL2RA, IFNG
47leukotriene b444 59 2412.8CXCL5, CR1, TNF, CCL3
48ivig4410.8IFNG
49pdtc4410.7IL18
505 aminosalicylic acid4410.4TNF, IL2RA, IL12B

GO Terms for genes affiliated with Sarcoidosis

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16Gene Ontology
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Cellular components related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3SFTPD, IFNG, PDGFB, TNF, CXCL5, CXCL9
2extracellular spaceGO:00561511.2TNF, PDGFB, IFNG, SFTPD, CCL3, LTA
3external side of plasma membraneGO:00989711.2ACE, IFNG, TNF, HLA-DRB1, CD80, CXCR3

Biological processes related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.4IL18, CXCL9, CXCL5, CD80, LTA, CCL3
2inflammatory responseGO:00695411.4IL9, IL18, CXCL9, CXCR3, TNF, CCL3
3immune responseGO:00695511.4HLA-DRB1, CXCL5, CXCL9, IL2RA, IL18, IL9
4negative regulation of growth of symbiont in hostGO:04413011.4NOD2, IL12B, LTA, TNF, IFNG
5positive regulation of tumor necrosis factor productionGO:03276011.4CCL3, IFNG, IL18, IL12B, NOD2
6positive regulation of interferon-gamma productionGO:03272911.4TNF, LTA, IL18, IL12B, IL12RB1
7positive regulation of activated T cell proliferationGO:04210411.3IL12RB1, IL12B, IL18, IL2RA
8cellular response to interferon-gammaGO:07134611.3CCL3, IL18, IL12B, IL12RB1
9positive regulation of ERK1 and ERK2 cascadeGO:07037411.2CCL3, PDGFB, TNF, NOD2
10chemotaxisGO:00693511.2CCL3, CXCR3, CXCL5, CXCL9
11response to hypoxiaGO:00166611.2PDGFB, TNF, LTA, IL18
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292511.2TNF, LTA, NOD2
13positive regulation of interleukin-17 productionGO:03274011.2IL18, IL12B, NOD2
14T-helper 1 type immune responseGO:04208811.2IL12B, IL18, HLA-DRB1
15positive regulation of osteoclast differentiationGO:04567211.2IFNG, TNF, IL12B
16positive regulation of interleukin-1 beta secretionGO:05071811.2NOD2, IFNG, CCL3
17positive regulation of NF-kappaB import into nucleusGO:04234611.2IL12B, IL18, TNF
18positive regulation of interleukin-12 productionGO:03273511.2NOD2, IL12B, IFNG
19lipopolysaccharide-mediated signaling pathwayGO:03166311.1CCL3, TNF, IL18
20cellular response to organic cyclic compoundGO:07140711.1CCL3, TNF, IL18
21negative regulation of T cell proliferationGO:04213011.1SFTPD, HLA-DRB1, IL2RA
22defense response to Gram-positive bacteriumGO:05083011.1TNF, LTA, NOD2
23humoral immune responseGO:00695911.1LTA, TNF, IFNG
24calcium-mediated signalingGO:01972211.1CXCR3, TNF, CCL3
25positive regulation of neuron apoptotic processGO:04352511.1CCL3, TNF, IL18
26positive regulation of inflammatory responseGO:05072911.1IL12B, IL18, CCL3
27positive regulation of vitamin D biosynthetic processGO:06055711.1IFNG, TNF
28interferon-gamma biosynthetic processGO:04209511.1IL18, IL12B
29positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.1TNF, LTA
30positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
31positive regulation of NK T cell proliferationGO:05114211.0IL18, IL12B
32positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL12B, IL12RB1
33MAPK cascadeGO:00016511.0CCL3, TNF, IL18
34T cell chemotaxisGO:01081811.0CCL3, CXCR3
35positive regulation of memory T cell differentiationGO:04338211.0IL12B, IL12RB1
36positive regulation of T-helper 17 type immune responseGO:200031811.0IL12B, IL12RB1
37positive regulation of tissue remodelingGO:03410510.9IL18, IL12B
38positive regulation of natural killer cell proliferationGO:03281910.9IL18, IL12B
39positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.9IL18, IL12B
40immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.9HLA-DRB1, NOD2
41epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.9PDGFB, TNF
42positive regulation of smooth muscle cell apoptotic processGO:03439310.9IFNG, IL12B
43positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9PDGFB, CD80, NOD2
44negative regulation of inflammatory response to antigenic stimulusGO:00286210.8IL12B, NOD2
45response to drugGO:04249310.8LTA, TNF, PDGFB, IFNG
46cell activationGO:00177510.8CCL3, TNF
47positive regulation of chemokine biosynthetic processGO:04508010.7IFNG, TNF
48positive regulation of interleukin-1 beta productionGO:03273110.7IL18, NOD2
49negative regulation of interleukin-17 productionGO:03270010.6IFNG, IL12B
50positive regulation of T-helper 1 type immune responseGO:00282710.4IL12RB1, IL12B

Molecular functions related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0IL9, IFNG, TNF, LTA, CXCL9, IL18
2interleukin-12 receptor bindingGO:00514310.7IL12RB1, IL12B
3chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3

Products for genes affiliated with Sarcoidosis

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Sources for Sarcoidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet