MCID: SRC013
MIFTS: 68

Sarcoidosis malady

Rare diseases, Immune diseases, Neuronal diseases, Eye diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Endocrine diseases categories
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Summaries for Sarcoidosis

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43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. the granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. the course of the disease varies from person to person. it often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. for those who need treatment, anti-inflammatory medications can help. last updated: 3/30/2010

MalaCards: Sarcoidosis, also known as boeck sarcoid, any site, is related to pulmonary sarcoidosis and blau syndrome. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Canonical NF-kappaB pathway and Immune response MIF mediated glucocorticoid regulation. The compounds mycophenolate sodium and 5 aminosalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

MedlinePlus:34 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

Wikipedia:65 Sarcoidosis, also called sarcoid, is a disease involving abnormal collections of inflammatory cells... more...

Aliases & Classifications for Sarcoidosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

sarcoidosis 8 43 10 45 34 62
boeck sarcoid, any site 8
lymphogranulomatosis 8
schaumann's disease 43
sarcoid of boeck 43


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Disease Ontology8 DOID:11335
MeSH35 D012507
NCIt40 C34995
SNOMED-CT58 154425004, 31541009
ICD9CM27 135
ICD1025 D86, D86.9

Related Diseases for Sarcoidosis

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17GeneCards, 18GeneDecks
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Diseases in the Sarcoidosis 1 family:

sarcoidosis Sarcoidosis 2
Sarcoidosis 3

Diseases related to Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary sarcoidosis31.1TRB, LTA, IL9, IL12B, IL12RB1, IL2RA
2blau syndrome30.7TNF, NOD2
3hepatitis30.6LTA, CR1, IL18
4thyroiditis30.6HLA-DRB1
5leprosy30.6HLA-DRB1
6asthma30.6TNF, IL12B
7pneumonia30.5SFTPD, CXCL5, TNF, CR1
8idiopathic pulmonary fibrosis30.5IFNG, IL18, CXCL5, CXCR3, IL9, CR1
9nephritis30.5LTA, ACE, IL18, CR1, CXCR3
10tuberculosis30.4IL2RA, IL18, IFNG, CXCR3, TNF, SFTPD
11extrinsic allergic alveolitis30.3IL2RA, SFTPD, CXCR3
12uveitis30.3IFNG, CXCR3, TNF, ACE, IL2RA, IL9
13hepatitis c30.3IL12B, IL18, IFNG, CXCR3, HLA-DRB1, CR1
14pleurisy30.3IL2RA, TRB
15lepromatous leprosy30.2LTA, IFNG
16lymphopenia30.2IFNG, IL18, IL2RA
17tuberculoid leprosy30.2IL2RA, IFNG
18spondylitis30.2NOD2
19pulmonary tuberculosis30.2HLA-DRB1, IFNG, IL2RA, IL12RB1, IL12B, IL18
20aspergillosis30.2IFNG, SFTPD
21lung cancer30.1CR1, IL9, TRB, SFTPD, CXCR3
22autoimmune thyroiditis30.1IL12B, IL2RA, CXCR3, IFNG
23diabetes mellitus30.1ACE, HLA-DRB1, TNF
24intermediate uveitis30.1IL2RA, CXCR3
25connective tissue disease30.1HLA-DRB1, TNF, IL2RA
26leishmaniasis30.1IFNG
27dermatitis30.0NOD2, CXCR3, IFNG, IL18
28leukemia30.0LTA, CR1, HLA-DRB1, CXCR3, IL2RA, IL9
29familial mediterranean fever30.0NOD2, TNF
30hodgkin's lymphoma30.0IL9, TRB, IL2RA, CR1, LTA
31arthritis30.0IL18, CR1, NOD2, LTA, TRB, IFNG
32eosinophilia29.9IFNG, IL2RA, IL9, IL18
33interstitial lung disease29.9SFTPD, TNF
34systemic lupus erythematosus29.9TRB, LTA, HLA-DRB1, TNF, CXCR3, IFNG
35juvenile rheumatoid arthritis29.9IL2RA, TRB, LTA, HLA-DRB1, TNF
36cystic fibrosis29.8CR1, IL9, SFTPD, TRB
37psoriatic arthritis29.8NOD2, LTA
38visceral leishmaniasis29.8LTA, IFNG
39skin disease29.8HLA-DRB1, IL2RA
40multiple sclerosis29.7HLA-DRB1, TNF, CXCR3, IFNG, IL18, IL2RA
41atopy29.7IFNG, IL18, LTA, CXCR3, NOD2, IL12B
42reticulosarcoma29.7TRB, CXCR3, IL9
43mycosis fungoides29.7IL2RA, CXCR3, TRB
44tetanus29.7LTA, IL9, IL2RA, IFNG
45hairy cell leukemia29.7CXCR3, IL2RA
46coronary artery disease29.6ACE, IL18, LTA
47sjogren's syndrome29.6TRB, IL2RA, CXCR3, CR1
48chronic lymphocytic leukemia29.6CR1, LTA, TRB, CXCR3, IL2RA
49non-hodgkin lymphoma29.6IL9, TRB, IL12B, IL2RA, HLA-DRB1
50behcet's disease29.6LTA, IL2RA, IL18, TNF

Graphical network of the top 20 diseases related to Sarcoidosis:



Diseases related to sarcoidosis

Symptoms for Sarcoidosis

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Drugs & Therapeutics for Sarcoidosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sarcoidosis

Search NIH Clinical Center for Sarcoidosis

Genetic Tests for Sarcoidosis

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Anatomical Context for Sarcoidosis

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33MalaCards
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MalaCards organs/tissues related to Sarcoidosis:

33
Lung, Lymph node, Testes, Skin, Heart, T cells, Liver, Eye, Monocytes, Thyroid, Breast, Bone, Endothelial, Kidney, Spinal cord, Myeloid, B cells, Spleen, Pancreas, Tonsil, Brain, Pineal, Nk cells, Testis, Prostate, Bone marrow, Colon, Skeletal muscle, Pituitary

Animal Models for Sarcoidosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sarcoidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9TRB, LTA, ACE, IFNG, TNF
2MP:00020068.3TNF, CXCR3, IFNG, ACE, IL12B, TRB
3MP:00053887.9SFTPD, TNF, CXCR3, IFNG, IL12B, LTA
4MP:00053817.8TNF, IFNG, IL18, IL2RA, IL12B, IL9
5MP:00053857.5TNF, CXCR3, IFNG, ACE, IL18, LTA
6MP:00053787.2SFTPD, TNF, IFNG, ACE, IL18, IL2RA
7MP:00053766.7SFTPD, TNF, CXCR3, IFNG, ACE, IL18
8MP:00107686.6IFNG, CXCR3, TNF, SFTPD, ACE, IL18
9MP:00053975.9TRB, SFTPD, TNF, CXCR3, IFNG, ACE
10MP:00053875.9ACE, IFNG, CXCR3, TNF, SFTPD, IL18

Publications for Sarcoidosis

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52PubMed
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Articles related to Sarcoidosis:

(show top 50)    (show all 2215)
idTitleAuthorsYear
1
Sarcoidosis in a chronic dialysis patient diagnosed by sarcoidosis-related hypercalcemia with no common systemic clinical manifestations: a case report and review of the literature. (24292755)
2013
2
Granuloma Formation in Pulmonary Sarcoidosis. (24339826)
2013
3
Cardiac Sarcoidosis: Electrophysiological Outcomes on Long-Term Follow-Up and the Role of the Implantable Cardioverter-Defibrillator. (24433308)
2013
4
Response to steroid therapy in cardiac sarcoidosis: insights from myocardial strain. (21990278)
2012
5
Development of cutaneous sarcoidosis during treatment with tumour necrosis alpha factor antagonists. (23157794)
2012
6
Cardiac sarcoidosis mimicking arrhythmogenic right ventricular dysplasia with high defibrillation threshold requiring subcutaneous shocking coil implantation. (21982156)
2012
7
Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. (22150367)
2012
8
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (22944174)
2012
9
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
10
Hypercalcemia and soft tissue calcification owing to sarcoidosis: the sunlight-cola connection. (20200968)
2010
11
Targeting the TNF-alpha pathway in sarcoidosis. (20001207)
2010
12
Cardiac sarcoidosis: recurrent disease in a heart transplant patient following pulmonary tuberculosis infection. (20847976)
2010
13
Hypothesis: sarcoidosis is a STAT1-mediated disease. (19464956)
2009
14
Clinical challenges and images in GI. Early peripancreatic and pulmonary sarcoidosis. (19013164)
2008
15
18F-FDG PET in sarcoidosis: an observational study in 12 patients treated with infliximab. (19382534)
2008
16
Inhibitors of tumor necrosis factor (TNF) in sarcoidosis: who, what, and how to use them. (19382527)
2008
17
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
18
CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)
2007
19
Tumor necrosis factor inhibition in the treatment of refractory sarcoidosis: slaying the dragon? (17985412)
2007
20
CD14 genetics in sarcoidosis patients; who's in control? (18496988)
2007
21
Genetics of sarcoidosis: candidate genes and genome scans. (17202299)
2007
22
Complementary appearance of glucose and lipid metabolism in cardiac sarcoidosis. (16872698)
2007
23
Images in cardiology. Biventricular involvement in cardiac sarcoidosis. (16230435)
2005
24
Tumor necrosis factor inhibition as a novel treatment for refractory sarcoidosis. (16208666)
2005
25
Relationship between basal thinning of the interventricular septum and atrioventricular block in patients with cardiac sarcoidosis. (15881282)
2005
26
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. (15653992)
2005
27
Association between IFNA genotype and the risk of sarcoidosis. (15004750)
2004
28
Large coalescent parenchymal nodules in pulmonary sarcoidosis: "sarcoid galaxy" sign. (12034602)
2002
29
Single-cell analysis: a novel approach to tumour necrosis factor-alpha synthesis and secretion in sarcoidosis. (12449172)
2002
30
Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis. (11790645)
2002
31
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. (11577764)
2001
32
Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis. (10957763)
2000
33
Hyperbaric chamber-related decompression illness in a patient with asymptomatic pulmonary sarcoidosis. (10373052)
1999
34
The angiotensin-converting enzyme DD gene is associated with poor prognosis in Finnish sarcoidosis patients. (10362030)
1999
35
The role of the C-C chemokine receptor 2 gene polymorphism V64I (CCR2-64I) in sarcoidosis in a Japanese population. (10351956)
1999
36
Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. (10390413)
1999
37
Sarcoidosis in a patient with linear IgA disease. (10233655)
1999
38
Selection of T lymphocytes bearing limited TCR-Vbeta regions in the lung of hypersensitivity pneumonitis and sarcoidosis. (9032199)
1997
39
Coccidioidomycosis and sarcoidosis. Multiple recurrences. (9217443)
1997
40
Is there an anatomic explanation for chest pain in patients with pulmonary sarcoidosis? (9305302)
1997
41
Glucocorticosteroids and pulmonary sarcoidosis. (8779121)
1996
42
Elevation of plasma-soluble tumour necrosis factor receptors (TNF-R) in sarcoidosis. (8625527)
1996
43
Endothelial cell damage in sarcoidosis and neurosarcoidosis: autoantibodies to endothelial cells. (7796836)
1995
44
Angiotensin-converting enzyme (ACE) polymorphism and serum ACE activities in sarcoidosis]. (8046841)
1994
45
Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. (8325116)
1993
46
Why perform high resolution computed tomography in pulmonary sarcoidosis? (8140309)
1993
47
Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations. (2180656)
1990
48
Two dimensional echocardiography and left ventriculography in cardiac sarcoidosis. (2631668)
1989
49
Nephrocalcinosis, hypercalcemia, sarcoidosis or primary hyperparathyroidism? (3983783)
1985
50
MYOCARDIAL DEGENERATION IN CARDIAC SARCOIDOSIS: HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES. (14256691)
1965

Variations for Sarcoidosis

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Expression for genes affiliated with Sarcoidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sarcoidosis

Search GEO for disease gene expression data for Sarcoidosis.

Pathways for genes affiliated with Sarcoidosis

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 30KEGG, 54R&D Systems, 55Reactome
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Pathways related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NOD2, TNF
29.9IFNG, TNF
3
Show member pathways
9.7TNF, IL12B, LTA
49.7IL18, IFNG
5
Show member pathways
9.7LTA, IFNG, TNF
6
Show member pathways
9.7LTA, IFNG, TNF
79.7TNF, IL18
89.6TNF, IFNG, IL12B
99.6LTA, IL9, IFNG
109.6IL12B, CXCL5, TNF
11
Show member pathways
9.5IFNG, IL12RB1, IL12B
12
Show member pathways
9.5TNF, IFNG, IL2RA
13
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.5TNF, IFNG, IL2RA
14
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.5IL2RA, IFNG, TNF
15
Show member pathways
9.4NOD2, IL18, IFNG
16
Show member pathways
9.4TNF, IL18, NOD2
179.4TNF, CXCL5, NOD2, LTA
18
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.4IL12B, ACE, IFNG, TNF
19
Show member pathways
9.4NOD2, IL2RA, IL18
209.3CR1, IL2RA, TNF, HLA-DRB1
219.3HLA-DRB1, TNF, IL2RA, LTA
22
Show member pathways
9.3IL2RA, IFNG, TNF, HLA-DRB1
23
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2TNF, IL2RA, IL9, LTA
249.2TNF, IL18, IL12B, CR1
259.2CR1, IL18, IFNG, TNF
269.2IFNG, IL2RA, IL12RB1, IL12B
279.1TNF, IFNG, IL18, IL12B
289.1TNF, IFNG, IL18, IL12B
299.0IL2RA, IL18, IFNG, HLA-DRB1
30
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0TRB, IL9, IFNG, TNF
318.8HLA-DRB1, TNF, IFNG, IL12B, TRB
32
Show member pathways
Type III interferon signaling38
8.8IFNG, IL2RA, IL12RB1, IL12B, IL9
33
Show member pathways
8.8HLA-DRB1, IFNG, IL18, IL2RA, NOD2
348.8IL18, IFNG, CXCL5, TNF, HLA-DRB1
35
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.7IL12B, IL12RB1, IL18, IFNG, TNF
36
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7SFTPD, TNF, IFNG, LTA, TRB
37
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6HLA-DRB1, IL2RA, IL12RB1, IL12B, TRB
388.6TNF, IFNG, IL18, IL12B, IL9, LTA
39
Show member pathways
IL27-mediated signaling events38
8.5TNF, IFNG, IL18, IL12RB1, IL12B, LTA
408.4HLA-DRB1, TNF, IFNG, IL18, IL12B, CR1
41
Show member pathways
8.3HLA-DRB1, TNF, IFNG, IL18, IL2RA, IL12B
42
Show member pathways
8.0HLA-DRB1, TNF, IFNG, IL18, IL12RB1, IL12B
43
Show member pathways
Immune response IL 12 induced IFN gamma production60
7.8HLA-DRB1, IFNG, IL18, IL2RA, IL12RB1, IL12B
44
Show member pathways
7.8TNF, IFNG, IL18, IL2RA, IL12RB1, IL12B
45
Show member pathways
7.5LTA, HLA-DRB1, TNF, IFNG, IL18, IL2RA
46
Show member pathways
7.1TNF, LTA, IL9, IL12B, IL12RB1, IL2RA
47
Show member pathways
7.1IL9, IL12B, IL12RB1, IL2RA, IL18, CXCL5
48
Show member pathways
7.1TNF, CXCR3, CXCL5, IL18, IL2RA, IL12RB1
49
Show member pathways
6.8TNF, CXCR3, CXCL5, IFNG, IL18, IL2RA

Compounds for genes affiliated with Sarcoidosis

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
See all sources

Compounds related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1mycophenolate sodium4510.0IL2RA, CR1
25 aminosalicylic acid459.8TNF, IL2RA, IL12B
3polymyxin b459.8CR1, TNF, IFNG
4okt3459.7IFNG, LTA, TNF, IL2RA
5gold sodium thiomalate459.7IL2RA, TNF, HLA-DRB1, IFNG
6ivig459.6LTA, IL2RA, IFNG, TNF
7tuberculin459.6IL2RA, IFNG, IL18
8indoleamine459.6IFNG, TNF, IL18
9lipoteichoic acid459.5TNF, LTA, IL12B, IL18
10imiquimod45 61 29 1112.5TNF, IFNG, IL18, IL12B
11polyinosinic-polycytidylic acid459.5IL12B, IFNG, IL18, TNF
12poly(i-c)459.5IL12B, IL18, TNF, IFNG
13natalizumab45 1110.4TNF, IL2RA, IL18, IFNG
14con a459.3IFNG, IL2RA, IL18
15thalidomide45 51 61 1112.3IL18, TNF, IL2RA, IFNG
16atorvastatin45 51 29 24 1113.2IL18, IL2RA, ACE, TNF
17herbimycin a45 6110.2IL2RA, TNF, IFNG, LTA
18mycophenolate mofetil45 51 1111.2IL18, LTA, IL2RA, TNF, IFNG
19neopterin459.2IFNG, LTA, IL2RA, IL18, TNF
20fmlp459.1LTA, CXCL5, TNF, CXCR3, CR1
21il-12459.1IFNG, IL18, IL12B, IL12RB1, TNF
22groalpha459.1TNF, IL18, CXCL5, CXCR3
23gm-csf45 2910.1IL18, IFNG, TNF
24indomethacin45 29 61 1112.0TNF, IL2RA, LTA, IFNG, IL18
25ifn-alpha459.0IFNG, IL18, IL2RA, CXCR3
26cycloheximide459.0LTA, TNF, IFNG, IL12B, IL18, CR1
27pentoxifylline45 1110.0LTA, IL12B, IL2RA, IL18, IFNG, TNF
28etanercept45 51 1110.9LTA, CXCR3, IFNG, IL18, TNF
29ccl345 299.8TNF, CXCR3, CXCL5, IFNG, IL18
30tacrolimus45 51 1110.5IFNG, CXCR3, IL2RA, TNF, IL18, NOD2
31tarc458.5IFNG, IL18, CXCL5, CXCR3, IL9, TNF
32oligonucleotide458.5SFTPD, HLA-DRB1, IL9, LTA, TRB, CXCL5
33ionomycin458.5LTA, IL9, IL12RB1, IL2RA, IFNG, IL18
34cyclosporin a45 29 6110.4TNF, TRB, LTA, CR1, IL2RA, IL18
35allergens458.4IL9, HLA-DRB1, SFTPD, IL18, CXCR3, IFNG
36infliximab45 51 1110.4LTA, NOD2, IFNG, TNF, IL18, IL2RA
37prednisolone45 29 1110.3IL2RA, TNF, SFTPD, IFNG, IL18, CR1
38rantes458.2CXCR3, IFNG, IL2RA, IL12B, IL9, IL18
39oxygen45 249.2CXCR3, TNF, IL18, SFTPD, CR1, NOD2
40vegf458.1TNF, LTA, CXCR3, CXCL5, IL2RA, IL18
41lipid458.1TNF, SFTPD, IL18, IL12B, ACE, LTA
42il 10458.1NOD2, IL12B, IL2RA, IL18, IFNG, LTA
43pge2458.0IL2RA, IL12B, LTA, IFNG, CXCL5, CXCR3
44histamine45 29 2410.0IL18, IL9, IL2RA, IFNG, CXCR3, TNF
45thymidine45 249.0CXCR3, IFNG, IL18, IL9, SFTPD, TNF
46endotoxin457.5TNF, SFTPD, LTA, NOD2, CXCR3, CXCL5
47dexamethasone45 51 29 1110.4IL2RA, IL12RB1, LTA, CXCR3, IL18, IFNG
48calcium45 51 24 1110.2CXCL5, SFTPD, CXCR3, CR1, ACE, IL18
49tyrosine457.1IL2RA, IL12RB1, IL9, TRB, CR1, LTA
50nitric oxide45 24 118.9IL18, CXCR3, TNF, IL12B, SFTPD, IL9

GO Terms for genes affiliated with Sarcoidosis

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16Gene Ontology
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Cellular components related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7IL18, ACE, IFNG, CXCL5, SFTPD
2external side of plasma membraneGO:0098977.9IL12RB1, HLA-DRB1, TNF, CXCR3, IFNG, ACE
3extracellular spaceGO:0056157.2SFTPD, TNF, CXCL5, IFNG, ACE, IL18

Biological processes related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.4TNF, LTA
2negative regulation of inflammatory response to antigenic stimulusGO:00286210.4IL12B, NOD2
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.3HLA-DRB1, NOD2
4positive regulation of vitamin D biosynthetic processGO:06055710.3TNF, IFNG
5positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3IFNG, TNF
6positive regulation of smooth muscle cell apoptotic processGO:03439310.3IL12B, IFNG
7negative regulation of interleukin-17 productionGO:03270010.3IFNG, IL12B
8detection of bacteriumGO:01604510.3HLA-DRB1, NOD2
9positive regulation of chemokine biosynthetic processGO:04508010.2TNF, IFNG
10positive regulation of T-helper 17 cell lineage commitmentGO:200033010.2IL12B, IL12RB1
11positive regulation of T-helper 17 type immune responseGO:200031810.2IL12RB1, IL12B
12positive regulation of interleukin-1 beta secretionGO:05071810.2IFNG, NOD2
13positive regulation of memory T cell differentiationGO:04338210.2IL12RB1, IL12B
14positive regulation of membrane protein ectodomain proteolysisGO:05104410.2IFNG, TNF
15defense response to protozoanGO:04283210.2IL12B, IFNG
16positive regulation of interleukin-10 productionGO:03273310.2NOD2, IL12B
17positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.2LTA, NOD2, TNF
18positive regulation of interleukin-12 productionGO:03273510.1NOD2, IL12B, IFNG
19defense response to Gram-positive bacteriumGO:05083010.1LTA, NOD2, TNF
20positive regulation of T-helper 1 type immune responseGO:00282710.1IL12RB1, IL12B
21interferon-gamma biosynthetic processGO:04209510.1IL18, IL12B
22positive regulation of tumor necrosis factor productionGO:03276010.1IFNG, IL12B, NOD2
23inflammatory response to antigenic stimulusGO:00243710.1HLA-DRB1, IL2RA
24positive regulation of NK T cell proliferationGO:05114210.1IL12B, IL18
25positive regulation of tissue remodelingGO:03410510.1IL18, IL12B
26positive regulation of defense response to virus by hostGO:00223010.1IL12B, IL12RB1
27positive regulation of natural killer cell proliferationGO:03281910.1IL18, IL12B
28positive regulation of osteoclast differentiationGO:04567210.1TNF, IFNG, IL12B
29positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.1IL18, IL12B
30humoral immune responseGO:00695910.1TNF, IFNG, LTA
31protein import into nucleus, translocationGO:00006010.0IFNG, TNF
32positive regulation of T cell mediated cytotoxicityGO:00191610.0IL12B, IL12RB1
33negative regulation of smooth muscle cell proliferationGO:0486629.9IL12B, IFNG
34natural killer cell activationGO:0301019.9IL18, IL12B
35positive regulation of interleukin-17 productionGO:0327409.9IL18, IL12B, NOD2
36negative regulation of interferon-gamma productionGO:0326899.9NOD2, HLA-DRB1
37T-helper 1 type immune responseGO:0420889.9IL12B, IL18, HLA-DRB1
38positive regulation of phagocytosisGO:0507669.9NOD2, SFTPD
39positive regulation of NF-kappaB import into nucleusGO:0423469.8TNF, IL18, IL12B
40defense response to bacteriumGO:0427429.8NOD2, IFNG, SFTPD
41cellular response to interferon-gammaGO:0713469.8IL12RB1, IL12B
42negative regulation of T cell proliferationGO:0421309.8IL2RA, SFTPD, HLA-DRB1
43negative regulation of growth of symbiont in hostGO:0441309.6LTA, NOD2, IL12B, IFNG, TNF
44positive regulation of activated T cell proliferationGO:0421049.4IL18, IL2RA, IL12RB1, IL12B
45lipopolysaccharide-mediated signaling pathwayGO:0316639.4IL18, TNF
46cell surface receptor signaling pathwayGO:0071669.3CXCR3, IFNG, IL2RA
47positive regulation of interferon-gamma productionGO:0327299.2TNF, IL18, IL12RB1, IL12B, LTA
48immune responseGO:0069559.1HLA-DRB1, CXCL5, IL18, IL2RA, IL9
49apoptotic processGO:0069159.0TNF, CXCR3, IFNG, IL2RA, LTA
50inflammatory responseGO:0069549.0IL9, IL18, CXCR3, TNF

Molecular functions related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00516410.0LTA, TNF
2interleukin-12 receptor bindingGO:0051439.7IL12RB1, IL12B
3cytokine receptor activityGO:0048969.5IL12B, IL12RB1
4cytokine activityGO:0051258.6LTA, IL9, IL12B, IL18, IFNG, TNF

Products for genes affiliated with Sarcoidosis

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  • Antibodies
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  • Antibodies

Sources for Sarcoidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet