MCID: SRC013
MIFTS: 60

Sarcoidosis malady

Immune category

Summaries for Sarcoidosis

Sources:
43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. the granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. the course of the disease varies from person to person. it often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. for those who need treatment, anti-inflammatory medications can help. last updated: 3/30/2010

MalaCards: Sarcoidosis, also known as boeck sarcoid, any site, is related to pulmonary sarcoidosis and tuberculosis. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Akt Signaling and PAK Pathway. The compounds nitric oxide and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

MedlinePlus:34 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

Wikipedia:64 Sarcoidosis (from sarc meaning \"flesh\", -oid, \"like\", and -osis, \"diseased or abnormal... more...

Aliases & Classifications for Sarcoidosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

sarcoidosis 8 43 10 45 34 61
boeck sarcoid, any site 8
lymphogranulomatosis 8
schaumann's disease 43
sarcoid of boeck 43


External Ids:

Disease Ontology8 DOID:11335
NCIt40 C34995
MeSH35 D012507
SNOMED-CT57 31541009, 154425004
ICD9CM27 135
ICD1025 D86, D86.9

Related Diseases for Sarcoidosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the sarcoidosis 1 family:

sarcoidosis sarcoidosis 2
sarcoidosis 3

Diseases related to Sarcoidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 487)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary sarcoidosis31.7ACE, IL12RB1, IL9, IL12B, IL18, IL2RA
2tuberculosis30.9NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL9
3idiopathic pulmonary fibrosis30.7IL9, IL18, CXCL9, CXCL5, CXCR3, CR1
4hypercalcemia30.6LTA, CCL3
5pulmonary tuberculosis30.5IL12RB1, IL12B, IL18, IL2RA, CD80, HLA-DRB1
6hepatitis c30.5IL12B, IL18, CXCR3, CR1, HLA-DRB1, TNF
7nephritis30.5ACE, IL18, CXCR3, LTA, CR1, PDGFB
8uveitis30.5ACE, NOD2, IL9, IL2RA, CXCL9, CXCR3
9asthma30.4IL12B, TNF
10systemic lupus erythematosus30.3NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCR3
11vasculitis30.3CD80, TNF
12arthritis30.3NOD2, IL18, CXCL9, CXCL5, CXCR3, CD80
13aspergillosis30.1IFNG, SFTPD, CCL3
14crohn's disease30.1NOD2, TNF
15bronchiolitis obliterans30.1CXCR3, PDGFB
16bronchiolitis30.1CCL3
17tuberculoid leprosy30.1IL2RA, IFNG
18lepromatous leprosy30.1LTA, IFNG
19ulcerative colitis30.0NOD2, IL12RB1, IL12B, IL18, IL2RA, CXCL5
20adenocarcinoma30.0CD80, PDGFB, SFTPD
21arthropathy30.0NOD2, TNF
22ankylosing spondylitis30.0TNF
23spondylitis30.0NOD2
24acute leukemia30.0IL9, CD80
25thyroiditis30.0HLA-DRB1
26atopy29.8NOD2, IL9, IL12B, IL18, CXCR3, LTA
27autoimmune thyroiditis29.8IL12B, IL2RA, CXCR3, CD80, IFNG
28cystic fibrosis29.8IL9, CD80, CR1, SFTPD
29juvenile rheumatoid arthritis29.8IL2RA, LTA, HLA-DRB1, TNF
30polymyositis29.8CD80, SFTPD, CCL3
31familial mediterranean fever29.8NOD2, TNF
32colorectal cancer29.8NOD2, CD80
33lichen planus29.8CXCL9, CXCR3
34tonsillitis29.8LTA
35graves' disease29.6IL12B, IL2RA, CXCR3, CD80, LTA, HLA-DRB1
36sjogren's syndrome29.6IL2RA, CXCL9, CXCR3, CD80, CR1, CCL3
37hepatitis b29.6IL12B, IL18, IL2RA, CR1, HLA-DRB1, IFNG
38pulmonary disease, chronic obstructive29.6IL9, CXCR3, CD80, TNF, SFTPD, CCL3
39tetanus29.6IL9, IL2RA, CD80, LTA, IFNG
40behcet's disease29.6IL18, IL2RA, LTA, TNF, CCL3
41coronary heart disease29.6ACE, IL18, LTA
42mycosis fungoides29.6IL2RA, CXCL9, CXCR3
43wegener's granulomatosis29.6CD80
44synovitis29.6IL18, TNF
45polymyalgia rheumatica29.6HLA-DRB1
46psoriatic arthritis29.6NOD2, LTA
47common variable immune deficiency29.6IL2RA
48paracoccidioidomycosis29.6CXCL9
49inclusion body myositis29.6CXCL9, CXCR3
50pancytopenia29.6IL2RA

Graphical network of the top 20 diseases related to Sarcoidosis:



Diseases related to sarcoidosis

Clinical Features for Sarcoidosis

Drugs & Therapeutics for Sarcoidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sarcoidosis

Drug clinical trials:

Search ClinicalTrials for Sarcoidosis

Search NIH Clinical Center for Sarcoidosis

Search CenterWatch for Sarcoidosis

Genetic Tests for Sarcoidosis

Anatomical Context for Sarcoidosis

Animal Models for Sarcoidosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Sarcoidosis

Sources:
51PubMed
See all sources

Articles related to Sarcoidosis:

(show top 50)    (show all 2238)
idTitleAuthorsYear
1
A patient with sarcoidosis who developed heterochronic involvements in different organs from initial organs during 7 years. (24388374)
2014
2
Pulmonary fibrosis in sarcoidosis. Clinical features and outcomes. (23952859)
2013
3
Human chitotriosidase: a sensitive biomarker of sarcoidosis. (22878841)
2013
4
Sulfasalazine induced lung toxicity masquerading as sarcoidosis - case report and review of the literature. (24284297)
2013
5
The Dark Lymph Node Sign on Magnetic Resonance Imaging: A Novel Finding in Patients With Sarcoidosis. (24157619)
2013
6
Anxiety, its relation to symptoms severity and anxiety sensitivity in sarcoidosis. (24351619)
2013
7
Diagnosis and monitoring of cardiac sarcoidosis with delayed-enhanced MRI and 18F-FDG PET-CT. (22466988)
2012
8
Sarcoidosis in a 65-year-old woman presenting with a lung mass and pericardial effusion: a case report. (22937889)
2012
9
Sarcoidosis and pain caused by small-fiber neuropathy. (23304492)
2012
10
Bone marrow involvement in sarcoidosis. (23405500)
2012
11
Concomitant Castleman's disease and sarcoidosis. (21326077)
2011
12
Ventricular tachycardia as the first manifestation of cardiac sarcoidosis. (21686620)
2009
13
Chitotriosidase activity in sarcoidosis and some other pulmonary diseases. (19347743)
2009
14
Sarcoidosis: a rare cause of Kleine-Levine-Critchley syndrome. (19070262)
2008
15
Ankylosing spondylitis and pulmonary sarcoidosis--a case report and discussion of the literature. (18812429)
2008
16
Sarcoidosis in patients with mixed connective tissue disease: clinical, genetic, serological and histological observations. (18196245)
2008
17
Progressive multifocal leukoencephalopathy as first manifestation of sarcoidosis. (17981390)
2008
18
Cardiac sarcoidosis. (18539240)
2008
19
Elevated alpha-defensin levels in plasma of patients with pulmonary sarcoidosis. (17539836)
2007
20
Usefulness of late gadolinium enhancement combined with MRI and 67-Ga scintigraphy in the diagnosis of cardiac sarcoidosis and disease activity evaluation. (16868855)
2007
21
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. (18092383)
2007
22
Role of CD4+ T cells in sarcoidosis. (17684290)
2007
23
Enhanced proliferation and decreased apoptosis in lung lavage cells of sarcoidosis patients. (18038918)
2006
24
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. (15653992)
2005
25
Sarcoidosis is associated with a truncating splice site mutation in BTNL2. (15735647)
2005
26
Study of C-C chemokine receptor 2 alleles in sarcoidosis, with emphasis on family-based analysis. (15750046)
2005
27
No association between interleukin-18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients. (15140035)
2004
28
Evaluation of bronchoalveolar lavage fluid phospholipids and cytokine release by alveolar macrophages as prognostic markers in sarcoidosis. (14512673)
2003
29
Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline]. (12921647)
2003
30
Exaggerated TNFalpha release of alveolar macrophages in corticosteroid resistant sarcoidosis. (12405487)
2002
31
Clinical bronchiectasis complicating pulmonary sarcoidosis: case series of seven patients. (12102612)
2002
32
Analysis of gene polymorphisms in interleukin-10 and transforming growth factor-beta 1 in sarcoidosis. (11436536)
2001
33
Immune restoration syndrome manifested by pulmonary sarcoidosis. (11717100)
2001
34
Cytokines TNF-alpha and GM-CSF in BAL from two different segments of lungs defined by high resolution computerized tomography (HRCT) in patients with sarcoidosis]. (11200748)
2000
35
Clinical aspects of pulmonary sarcoidosis. (10670174)
2000
36
Detection of TNF-alpha and NCF in the serum and BALF of patients with sarcoidosis and evaluate their clinical significance]. (11812354)
1999
37
Immunohistochemical localization of B7 costimulating molecules and major histocompatibility complex class II antigen in pulmonary sarcoidosis. (10461083)
1999
38
Pentoxifylline in treatment of sarcoidosis. (9154873)
1997
39
Elevation of plasma-soluble tumour necrosis factor receptors (TNF-R) in sarcoidosis. (8625527)
1996
40
Cross-reactive and species specific Mycobacterium tuberculosis antigens in the immunoprofile of Schaumann bodies: a major clue to the etiology of sarcoidosis. (8720456)
1996
41
Aspecific bronchial hyperreactivity in pulmonary sarcoidosis. (7809495)
1994
42
Elevated negative predictive value of angiotensin converting enzyme in the diagnosis of active sarcoidosis]. (8256006)
1993
43
Serum angiotensin-converting enzyme as a marker for the chronic fatigue-immune dysfunction syndrome: a comparison to serum angiotensin-converting enzyme in sarcoidosis. (8213873)
1993
44
Massive splenomegaly in sarcoidosis. (1631702)
1992
45
Adverse effect of chronic tonsillitis on clinical course of sarcoidosis. (1669976)
1991
46
Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis. (2299255)
1990
47
Pulmonary sarcoidosis: evaluation with high-resolution CT. (2748828)
1989
48
Sarcoidosis and malakoplakia. (167490)
1975
49
Letter: Secondary syphilis and sarcoidosis. (1115517)
1975
50
Sarcoidosis with skin lesions simulating necrobiosis lipoidica. (13453416)
1957

Genetic Variations for Sarcoidosis

Expression for genes affiliated with Sarcoidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sarcoidosis

Search GEO for disease gene expression data for Sarcoidosis.

Pathways for genes affiliated with Sarcoidosis

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Sarcoidosis according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6TNF, LTA, CD80, CXCR3, CXCL5, CXCL9
2
Hide members
11.4IL12RB1, IL9, CCL3, PDGFB, LTA, CD80
3
Hide members
11.4IFNG, IL12RB1, TNF, HLA-DRB1, LTA, CD80
4
Hide members
11.4CCL3, PDGFB, LTA, CD80, CXCR3, CXCL5
5
Hide members
11.3CCL3, PDGFB, CD80, CXCR3, CXCL5, CXCL9
6
Hide members
11.2IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
711.1IFNG, TNF, HLA-DRB1, CR1, IL18, IL12B
8
Hide members
11.1IFNG, TNF, HLA-DRB1, LTA, IL2RA, IL18
9
Hide members
11.1IFNG, TNF, LTA, CD80, IL18, IL12B
10
Hide members
11.1IFNG, PDGFB, HLA-DRB1, CR1, CD80, IL2RA
11
Hide members
11.1CCL3, IFNG, HLA-DRB1, IL2RA, IL18, IL12B
12
Hide members
11.1CCL3, IFNG, TNF, CD80, CXCL9, IL12B
13
Development PDGF signaling via STATs and NF-kB
Hide members
11.1IFNG, PDGFB, TNF, CXCL9, IL18, IL12B
14
Hide members
11.1PDGFB, LTA, CD80, IL2RA, IL12B, IL9
1511.0IFNG, TNF, LTA, IL18, IL12B, IL9
16
Hide members
10.9NOD2, IL18, IL2RA, HLA-DRB1, IFNG
1710.9IFNG, IL2RA, IL12B, IL9, IL12RB1
1810.8IL2RA, CR1, HLA-DRB1, TNF
1910.8IL12B, IL18, CR1, TNF
2010.8TNF, LTA, CXCL5, NOD2
2110.8IL12B, IL18, TNF, IFNG
2210.8IFNG, TNF, IL18, IL12B
2310.8IFNG, HLA-DRB1, IL2RA, IL18
24
Hide members
10.8TNF, LTA, IL2RA, IL9
25
Hide members
10.8IFNG, PDGFB, TNF, LTA
2610.8IFNG, IL2RA, IL12B, IL12RB1
2710.8HLA-DRB1, IL2RA, IL12B, IL12RB1
28
Hide members
10.8IFNG, TNF, HLA-DRB1, CD80
29
Hide members
10.8IL9, LTA, TNF, PDGFB
30
Hide members
10.8IL2RA, TNF, IFNG, CCL3
31
Hide members
10.8CCL3, CXCR3, CXCL5, CXCL9
3210.8CCL3, CXCR3, CXCL5, CXCL9
33
Hide members
10.7LTA, TNF, IFNG
34
Hide members
10.7NOD2, IL18, TNF
3510.7IFNG, LTA, IL9
3610.7IFNG, TNF, IL2RA
37
Hide members
10.7IL2RA, TNF, IFNG
38
Immune response Bacterial infections in normal airways
10.7SFTPD, IFNG, TNF
3910.7IL12B, CXCL5, TNF
4010.7IL2RA, CD80, IFNG
4110.7IL18, IFNG, CCL3
4210.7HLA-DRB1, IL12B
4310.7IL18, CR1
4410.7IL2RA, PDGFB
4510.7IL18, CD80
4610.6IL12RB1, CD80

Compounds for genes affiliated with Sarcoidosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1nitric oxide45 11 2414.3ACE, NOD2, IL9, CCL3, SFTPD, IFNG
2tyrosine4511.9CXCL9, IL9, IL12RB1, IL2RA, IL18, CXCL5
3calcium45 50 11 2414.8CXCL9, CXCL5, CR1, CCL3, SFTPD, CD80
4il 104511.8NOD2, IL12B, IL18, IL2RA, CXCL9, CXCR3
5ionomycin4511.8CXCL9, IFNG, CCL3, TNF, LTA, CD80
6vegf4511.8IFNG, CCL3, PDGFB, TNF, CXCR3, CXCL5
7rantes4511.7CXCL5, CXCR3, LTA, TNF, IFNG, CCL3
8cyclosporin a45 29 6013.7PDGFB, IL2RA, CCL3, IFNG, TNF, CR1
9histamine45 29 2413.7IL9, CCL3, SFTPD, IFNG, CXCL9, CXCR3
10thymidine45 2412.7PDGFB, SFTPD, IL18, CCL3, TNF, IL9
11tarc4511.6CXCR3, CXCL5, CXCL9, IL18, IL9, CCL3
12infliximab45 50 1113.5CXCR3, IFNG, TNF, LTA, IL2RA, IL18
13ccl345 2912.5IL18, CXCL9, CXCL5, CXCR3, TNF, IFNG
14allergens4511.5IL9, IL18, SFTPD, HLA-DRB1, IFNG, CD80
15groalpha4511.4CXCL9, CXCL5, CXCR3, IL18, TNF, CCL3
16neopterin4511.4CCL3, TNF, LTA, IL2RA, IL18, IFNG
17prednisolone45 29 1113.4SFTPD, LTA, IL2RA, NOD2, CR1
18dexamethasone45 50 29 1114.4SFTPD, PDGFB, CXCL9, CD80, LTA
19il-124511.3IL18, TNF, IL12RB1, IFNG, IL12B
20tacrolimus45 50 1113.3IL2RA, CCL3, IFNG, PDGFB, CXCR3
21lipoteichoic acid4511.3TNF, LTA, IL12B, IL18, CCL3
22polyinosinic-polycytidylic acid4511.3IFNG, CCL3, IL12B, TNF, IL18
23oxygen45 2412.3CCL3, CR1, TNF, CD80, SFTPD
24etanercept45 50 1113.3IFNG, TNF, LTA, CXCR3, IL18
25poly(i-c)4511.3IL18, TNF, IFNG, IL12B, CCL3
26pd 98,0594511.3IL18, CXCR3, TNF, PDGFB, CCL3, IL12B
27ccl445 2912.3IL12B, CXCR3, CXCL5, CCL3, CXCL9
28ifn-alpha4511.3IL18, IL2RA, CXCL9, CXCR3, IFNG
29cycloheximide4511.2IL18, PDGFB, CR1, LTA
30tgf beta14511.2TNF, LTA, PDGFB, CCL3, IL18
31gold sodium thiomalate4511.2TNF, IFNG, HLA-DRB1, IL2RA
32serine4511.2IL18, LTA, CCL3, NOD2, TNF, IL9
33mannose4511.2NOD2, CD80, CR1, LTA, SFTPD
34natalizumab45 1112.2IFNG, TNF, IL18, IL2RA
35pentoxifylline45 1112.2LTA, IL18, IL12B
36fmlp4511.2CCL3, CXCL5, CXCR3, CR1
37imiquimod45 29 60 1114.2TNF, IFNG, IL18, IL12B
38okt34511.1LTA, TNF, IFNG, IL2RA
39endotoxin4511.1CXCL5, CXCR3
40peptidoglycan45 2912.1NOD2, IL12B, TNF, CCL3
41ribavirin45 50 1113.0CCL3, IFNG, IL18, CXCR3
42phosphatidylinositol4511.0CXCR3, IL2RA, SFTPD, IL12B, CD80, CR1
43gm-csf45 2911.9IFNG, TNF
44toxin-14510.9LTA, CCL3, TNF
45thalidomide45 50 60 1113.9IFNG, IL18, IL2RA, TNF
46tuberculin4510.9IL2RA, IL18, IFNG
47leukotriene b445 60 2412.8CXCL5, CR1, TNF, CCL3
48ivig4510.8IFNG
49pdtc4510.7IL18
505 aminosalicylic acid4510.4TNF, IL2RA, IL12B

GO Terms for genes affiliated with Sarcoidosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3IL18, CXCL9, CXCL5, TNF, PDGFB, IFNG
2extracellular spaceGO:00561511.2TNF, PDGFB, IFNG, SFTPD, CCL3, LTA
3external side of plasma membraneGO:00989711.2IFNG, ACE, IL12RB1, IL2RA, CXCL9, CXCR3

Biological processes related to Sarcoidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.4CCL3, IL18, CXCL9, CXCL5, LTA, CD80
2inflammatory responseGO:00695411.4CCL3, CXCL9, IL18, TNF, CXCR3, IL9
3immune responseGO:00695511.4CXCL5, IL2RA, CXCL9, IL9, HLA-DRB1, IL18
4negative regulation of growth of symbiont in hostGO:04413011.4NOD2, IL12B, TNF, LTA, IFNG
5positive regulation of tumor necrosis factor productionGO:03276011.4CCL3, IFNG, IL18, IL12B, NOD2
6positive regulation of interferon-gamma productionGO:03272911.4TNF, IL12B, LTA, IL18, IL12RB1
7positive regulation of activated T cell proliferationGO:04210411.3IL12B, IL18, IL2RA, IL12RB1
8cellular response to interferon-gammaGO:07134611.3IL18, IL12B, IL12RB1, CCL3
9positive regulation of ERK1 and ERK2 cascadeGO:07037411.2PDGFB, CCL3, TNF, NOD2
10chemotaxisGO:00693511.2CCL3, CXCR3, CXCL5, CXCL9
11response to hypoxiaGO:00166611.2IL18, TNF, PDGFB, LTA
12positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292511.2LTA, TNF, NOD2
13positive regulation of interleukin-17 productionGO:03274011.2NOD2, IL18, IL12B
14T-helper 1 type immune responseGO:04208811.2IL12B, HLA-DRB1, IL18
15positive regulation of osteoclast differentiationGO:04567211.2IFNG, IL12B, TNF
16positive regulation of interleukin-1 beta secretionGO:05071811.2CCL3, NOD2, IFNG
17positive regulation of NF-kappaB import into nucleusGO:04234611.2TNF, IL12B, IL18
18positive regulation of interleukin-12 productionGO:03273511.2IFNG, IL12B, NOD2
19lipopolysaccharide-mediated signaling pathwayGO:03166311.1IL18, TNF, CCL3
20negative regulation of T cell proliferationGO:04213011.1HLA-DRB1, SFTPD, IL2RA
21cellular response to organic cyclic compoundGO:07140711.1TNF, CCL3, IL18
22defense response to Gram-positive bacteriumGO:05083011.1TNF, NOD2, LTA
23humoral immune responseGO:00695911.1TNF, LTA, IFNG
24calcium-mediated signalingGO:01972211.1CXCR3, TNF, CCL3
25positive regulation of neuron apoptotic processGO:04352511.1IL18, TNF, CCL3
26positive regulation of inflammatory responseGO:05072911.1IL18, IL12B, CCL3
27positive regulation of vitamin D biosynthetic processGO:06055711.1TNF, IFNG
28positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.1LTA, TNF
29interferon-gamma biosynthetic processGO:04209511.1IL12B, IL18
30positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
31positive regulation of NK T cell proliferationGO:05114211.0IL18, IL12B
32positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL12RB1, IL12B
33MAPK cascadeGO:00016511.0CCL3, TNF, IL18
34T cell chemotaxisGO:01081811.0CCL3, CXCR3
35positive regulation of memory T cell differentiationGO:04338211.0IL12RB1, IL12B
36positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272511.0IL12B, IL18
37positive regulation of T-helper 17 type immune responseGO:200031810.9IL12B, IL12RB1
38positive regulation of natural killer cell proliferationGO:03281910.9IL18, IL12B
39positive regulation of tissue remodelingGO:03410510.9IL12B, IL18
40immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.9HLA-DRB1, NOD2
41positive regulation of smooth muscle cell apoptotic processGO:03439310.9IL12B, IFNG
42cell activationGO:00177510.9CCL3, TNF
43positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9NOD2, CD80, PDGFB
44response to drugGO:04249310.8TNF, IFNG, PDGFB, LTA
45epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.8PDGFB, TNF
46negative regulation of inflammatory response to antigenic stimulusGO:00286210.8NOD2, IL12B
47positive regulation of chemokine biosynthetic processGO:04508010.7IFNG, TNF
48negative regulation of interleukin-17 productionGO:03270010.7IL12B, IFNG
49positive regulation of interleukin-1 beta productionGO:03273110.6NOD2, IL18
50positive regulation of T-helper 1 type immune responseGO:00282710.4IL12B, IL12RB1

Molecular functions related to Sarcoidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0IL9, IFNG, TNF, LTA, CXCL9, IL18
2interleukin-12 receptor bindingGO:00514310.7IL12RB1, IL12B
3chemokine activityGO:00800910.4CXCL9, CXCL5, CCL3

Products for genes affiliated with Sarcoidosis

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  • Proteins
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  • Antibodies

Sources for Sarcoidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet