Sarcoidosis malady

MedlinePlus: Sarcoidosis is an inflammatory disease. it starts as tiny, grain-like lumps called granulomas, which most often appear in your lungs or lymph nodes. they can clump together and form larger lumps that attack other organs. sarcoidosis often affects your skin, eyes or liver. sarcoidosis may be mild, or it can be severe and do lasting damage. it does not always cause symptoms, so you can have it without knowing it. symptoms vary, depending on which organs are affected. no one is sure what causes sarcoidosis. it affects men and women of all ages and races worldwide. however, it occurs mostly in people ages 20 to 40, african americans, especially women, and people of asian, german, irish, puerto rican and scandinavian origin. nih: national heart, lung, and blood institute²³

MalaCards: Sarcoidosis, also known as boeck sarcoid, any site, is related to pulmonary sarcoidosis and cardiac sarcoidosis. An important gene associated with Sarcoidosis is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Cytokine-cytokine receptor interaction and Chemokine Signaling. The drugs cyclophosphamide and cisplatin pwdr [va product] and the compounds il 10 and tarc have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and spinal cord, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

NIH Rare Diseases: Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. If these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. The granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. Although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system. The course of the disease varies from person to person. It often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. For those who need treatment, anti-inflammatory medications can help.³⁰

Genetics Home Reference: Blau syndrome is an inflammatory disorder that primarily affects the skin, joints, and eyes. Signs and symptoms begin in childhood, usually before age 4.¹⁷

Wikipedia: Sarcoidosis (from sarc meaning \"flesh\", -oid, \"like\", and -osis, \"diseased or abnormal...⁴⁴ more...

Aliases & Descriptions:

sarcoidosis 6 7 30 8 32 23 43 boeck sarcoid, any site 6 lymphogranulomatosis 6

schaumann's disease 30 sarcoid of boeck 30 hodgkin disease 43

Disease types for sarcoidosis family:

sarcoidosis 2	sarcoidosis 3

Diseases related to sarcoidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 968)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary sarcoidosis	41.2	SFTPD, SELL, LBR, CD80, ITGA4, ITGAL
2	cardiac sarcoidosis	34.8	SEMA7A, S100A8, S100A9, AURKC, IL12B, IL15
3	tuberculosis	34.7	VDR, P2RX7, IL10, IL12B, IL1B, IL1RN
4	blau syndrome	33.5	IL10, IL1B, IL1RAPL2, TNF, NOD1, NOD2
5	idiopathic pulmonary fibrosis	33.2	MMP1, MMP7, FN1, IL1B, IL1R1, IL1RN
6	asthma	32.9	SCGB1A1, IL12B, IL13, CCL11, HLA-G, TNF
7	hepatitis	32.6	SELP, CD58, GZMB, IL2RB, FASLG, FAS
8	hepatitis c	32.4	CD28, CD69, MMP1, IL10, IL12B, IL18
9	uveitis	31.5	KIR2DL3, SFTPD, RCVRN, SELE, SELL, VEGFA
10	pulmonary tuberculosis	31.0	VDR, P2RX7, CD14, CD80, IL10, IL12B
11	systemic lupus erythematosus	30.9	VTN, SELE, VCAM1, CLEC12A, CHI3L1, LBR
12	pulmonary fibrosis	30.9	VTN, SFTPD, SELE, SEMA7A, VIM, VEGFA
13	burkitt's lymphoma	30.7	BCL2L1, CD27, CD44, ITGA4, ITGAL, FCER2
14	intermediate uveitis	30.5	CD69, IL10, IL2RA, CCR4, CCR5, IFNG
15	pars planitis	30.4	CD27, IL1RN, HLA-A, HLA-B, HLA-DRB1
16	anaplastic large cell lymphoma	30.4	SERPINA3, BCL2L1, CDKN1A, CD4, CD44, CD68
17	extrinsic allergic alveolitis	30.4	VTN, SFTPD, CD14, CD80, FCER2, IL18
18	non-hodgkin lymphoma	30.0	SELL, VDR, BCL2L1, LBR, B2M, CD28
19	crohn's disease	29.9	CHI3L1, CD80, ITGA1, FOXP3, MIF, IL10
20	b-cell lymphomas	29.8	BCL2L1, CD58, CDKN1A, CD14, CD80, CD44
21	usual interstitial pneumonia	29.7	CLDN5, IL13, IL8, CCL2, IFNG, TNC
22	hodgkin's lymphoma	29.6	SELP, BCL2L1, CD28, CD80, CD68, ITGA4
23	retinal vasculitis	29.6	APOH, CCL4, IFN1@, IFNA2, IFNB1, TNF
24	interstitial lung disease	29.2	VTN, SFTPD, LBR, ITGAM, GRP, IL1A
25	acquired immunodeficiency syndrome	29.0	SFTPD, CLEC12A, LBR, B2M, CD28, CD69
26	immunodeficiency	28.8	SELL, CD28, CD79A, CD69, CD4, CD80
27	respiratory failure	28.4	SFTPD, CMA1, SCGB1A1, CFTR, IL13, CCL11
28	splenomegaly	28.4	VEGFA, CHIT1, GRP, IL10, IL2RA, FASLG
29	bronchial asthma	28.3	SFTPD, SELE, SELL, SELP, VEGFA, VCAM1
30	chronic granulomatous disease	28.3	SELE, S100A8, S100A9, CD79A, CD14, IL1RAPL2
31	bronchitis	28.3	S100A8, S100A9, CFTR, IL5, IL8, IL9
32	lymphoproliferative syndrome	28.2	CD27, IL10, IL2, IL2RA, FASLG, FAS
33	connective tissue disease	28.2	SFTPD, S100A9, APOH, ENO1, TRB@, COL1A1
34	fibrosis	28.1	VTN, SFTPD, SELE, SELL, SELP, SEMA7A
35	autoimmune lymphoproliferative syndrome	27.9	CD4, IL10, IL2RA, FASLG, FAS, IGHE
36	mixed connective tissue disease	27.9	PIK3C2A, S100A8, S100A9, IL6, APOH, HLA-A
37	silicosis	27.6	SFTPD, SCGB1A1, B2M, CDKN1A, GSTP1, IL10
38	histoplasmosis	27.6	CD79A, CD4, CD80, IFNG, HLA-A, HLA-B
39	ataxia telangiectasia	27.5	VIM, LBR, CD28, CD79A, CDKN1A, CD69
40	addison's disease	27.1	VDR, CD79A, FOXP3, FCGR3A, CCR2, CCR5
41	tuberculous meningitis	27.1	IL10, IL1B, IL8, MBL2, CCL3, IFNG
42	thrombocytopenia	27.0	PIK3C2A, SELE, SELL, SELP, CHIT1, CD79A
43	meningoencephalitis	26.9	B2M, CD79A, CD4, IL6, CCL5, ALB
44	hypercalcemia	26.9	VIM, VDR, B2M, IRF4, IL1A, IL1B
45	lupus erythematosus	26.4	PIK3C2A, KIR2DL3, VTN, SFTPD, BTNL2, SELE
46	systemic lupus erythematosus, association with	26.4	ITGAM, GSTP1, FCGR3A, IL10, IL18, IL1A
47	hypoglycemia	26.1	VIM, VEGFA, P2RX7, CD79A, MIF, IL1B
48	pulmonary disease	26.0	SFTPD, SELE, SELL, SELP, SERPINA3, VEGFA
49	testicular cancer	26.0	B2M, CDKN1A, MMP9, GSTP1, IL2RA, IL6
50	pulmonary function	26.0	CFTR, CD14, IL10, IL13, IL18, IL1RAPL2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate, carmustine, chlorambucil, cisplatin, cisplatin pwdr [va product], cyclophosphamide, dacarbazine, ifosfamide, lomustine, mechlorethamine, mechlorethamine hydrochloride, procarbazine, procarbazine hydrochloride, sargramostim, streptozocin, vinblastine, vinblastine sulfate, vincristine, vincristine sulfate, vinorelbine, vinorelbine tartrate

MalaCards organs/tissues related to sarcoidosis:

²²

MGI Mouse Phenotypes related to sarcoidosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.3	BCL2L1, MT2A, P2RX7, UACA, MST1, CD28
2	digestive/alimentary phenotype	MP:0005381	10.8	VEGFA, VDR, LBR, MT2A, B2M, CFTR
3	respiratory system phenotype	MP:0005388	10.8	SFTPD, SELL, SELP, SCGB1A1, MT2A, UACA
4	nervous system phenotype	MP:0003631	10.6	SELP, SEMA7A, BCL2L1, LBR, MT2A, CD28
5	craniofacial phenotype	MP:0005382	10.4	LBR, CFTR, ITGA4, FOXP3, GREM1, IL12B
6	liver/biliary system phenotype	MP:0005370	10.4	VEGFA, MT2A, UACA, CFTR, MST1, IL12RB2
7	endocrine/exocrine gland phenotype	MP:0005379	10.3	SELL, UACA, IL2, IL2RB, FASLG, IFNG
8	immune system phenotype	MP:0005387	10.3	SELL, SELP, VIM, VDR, CMA1, KDR
9	renal/urinary system phenotype	MP:0005367	10.1	SELP, SCGB1A1, MT2A, UACA, CDKN1A, ITGA1
10	mortality/aging	MP:0010768	9.9	PIK3C2A, SFTPD, SELE, SELP, VEGFA, VDR
11	embryogenesis phenotype	MP:0005380	9.9	VIM, MRC1, ITGA4, IL5, ALPP, GLI1
12	other phenotype	MP:0005395	9.7	KDR, FN1, IL13, IL2, CCR2, CASR
13	reproductive system phenotype	MP:0005389	9.7	VEGFA, VDR, MT2A, UACA, B2M, AURKC
14	growth/size phenotype	MP:0005378	9.6	PIK3C2A, SFTPD, SELE, SELP, VDR, VCAM1
15	vision/eye phenotype	MP:0005391	9.6	RCVRN, SELE, SELP, VIM, VEGFA, KDR
16	tumorigenesis	MP:0002006	9.6	SELL, BCL2L1, SCGB1A1, MT2A, UACA, B2M
17	adipose tissue phenotype	MP:0005375	9.6	PIK3C2A, LBR, CDKN1A, CD14, IL18, IL1R1
18	no phenotypic analysis	MP:0003012	9.4	VEGFA, VCAM1, LBR, CD79A, CD69, CD4
19	integument phenotype	MP:0010771	9.3	SELP, BCL2L1, LBR, P2RX7, UACA, CDKN1A
20	behavior/neurological phenotype	MP:0005386	8.9	SELE, SELP, VIM, KDR, LBR, MT2A
21	normal phenotype	MP:0002873	8.8	VTN, SELE, VEGFA, KDR, SCGB1A1, MT2A
22	skeleton phenotype	MP:0005390	8.8	VEGFA, VDR, KDR, MT2A, P2RX7, CDKN1A
23	cellular phenotype	MP:0005384	8.8	SELE, SELL, SELP, SEMA7A, VIM, VEGFA
24	muscle phenotype	MP:0005369	7.7	VIM, VEGFA, KDR, CDKN1A, CD86, CD44
25	cardiovascular system phenotype	MP:0005385	6.9	SELE, SELL, SELP, VIM, VEGFA, VDR
26	homeostasis/metabolism phenotype	MP:0005376	5.7	PIK3C2A, VTN, SFTPD, SELE, SELL, SELP

Articles related to sarcoidosis:

(show top 50)    (show all 615)

id	Title	Authors	Year	Affiliating Genes
1	ApoE-deficient mice on cholate-containing high-fat di et reveal a pathology similar to lung sarcoidosis. (20093498)	Samokhin A.O.... BrAPmme D.	2010	SPP1
2	High extracellular induced sputum haem oxygenase-1 in sarcoidosis and chronic beryllium disease. (19453654)	Kokturk N.... Fireman E.	2009	HMOX1
3	Refractory chronic cutaneous sarcoidosis responsive t o dose escalation of TNF-alpha antagonists. (19468200)	Thielen A.M.... Laffitte E.	2009	TNF
4	M. avium binding to HLA-DR expressed alleles in silic o: a model of phenotypic susceptibility to sarcoidosis. (19382529)	Saltini C.... Amicosante M.	2008	HLA-DRB1
5	Fas promoter polymorphisms: genetic predisposition to sarcoidosis in African-Americans. (18588573)	Wasfi Y.S.... Maier L.A.	2008	FAS
6	Association of the 3050G>C polymorphism in the cyclooxygenase 2 gene with systemic sarcoidosis. (18514098)	Lopez-Campos J.L.... Montes-Worboys A.	2008	PTGS2
7	Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. (18723019)	Franke A.... Schreiber S.	2008	C10orf67
8	Analysis of HLA antigens in Turkish sarcoidosis patients. (17458393)	Bilir M.... Erdogan E.	2007	HLA-A, HLA-DRB1, HLA-B
9	Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis. (17661910)	Spagnolo P.... Welsh K.I.	2007	HLA-DRB1, BTNL2
10	CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. (17550373)	Nishioka Y.... Sone S.	2007	CXCR3, CXCL9
11	Infliximab for the therapy of chronic sarcoidosis, Baughman RP, Drent M, Kavuru M et al.: Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am. J. Respir. Crit. Care Med. (2006) 174(7):795-802. (17461746)	Antoniu S.A.	2007	TNF
12	Effects of FOXP3 gene polymorphism in sarcoidosis patients. (18496979)	Takano Y.... Ueda R.	2007	FOXP3
13	X-linked chronic granulomatous disease (CGD) caused by an intra-exonic splice mutation (CYBB exon 3, c.262G->A) is mimicking juvenile sarcoidosis. (17543165)	Brunner J.... Roesler J.	2007	CYBB
14	HSP70-hom gene single nucleotide (+2763 G/A and +2437 C/T) polymorphisms in sarcoidosis. (16611259)	Bogunia-Kubik K.... Lange A.	2006	HLA-DRB1, HSPA1L
15	Upregulation of Th1 cytokine profile (IL-12, IL-18) in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis. (16734560)	Antoniou K.M.... Siafakas N.M.	2006	IL18
16	Expression of CCX CKR in pulmonary sarcoidosis. (17109071)	Kriegova E.... Petrek M.	2006	CCL25, CCRL1
17	Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy. (16053028)	Voorter C.E.... van den Berg-Loonen E.M.	2005	HLA-A, HLA-DQB1, HLA-DRB1
18	Sarcoidosis is associated with a truncating splice site mutation in BTNL2. (15735647)	Valentonyte R.... Schreiber S.	2005	HLA-DRB1, BTNL2
19	Role for CXCR6 and its ligand CXCL16 in the pathogenesis of T-cell alveolitis in sarcoidosis. (16100013)	Agostini C.... Semenzato G.	2005	CXCR3, CXCL10, CXCR6
20	No association between interleukin-18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients. (15140035)	Janssen R.... van den Bosch J.M.	2004	IL18
21	Infliximab treatment of sarcoidosis. (12659618)	Serio R.N.	2003	TNF
22	Expression of sarcoidosis related genes in lung lavage cells. (12002387)	Thonhofer R.... Popper H.H.	2002	FABP4
23	Increased macrophage inflammatory protein-1alpha and macrophage inflammatory protein-1beta levels in bronchoalveolar lavage fluid of patients affected by different stages of pulmonary sarcoidosis. (11790661)	Capelli A.... Donner C.F.	2002	CCL4, CCL3
24	Manifestation of sarcoidosis during interferon and ribavirin therapy for chronic hepatitis C: a report of two cases. (12172411)	Gitlin N.	2002	ACE
25	KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (11694811)	Kunitake R.... Hara N.	2001	SFTPD
26	Sarcoidosis during the treatment of hepatitis C by interferon-alpha and ribavirin: 2 cases (11794896)	LAcvA-que L.... Besancenot J.F.	2001	IFNA1
27	HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis. (11169267)	Bogunia-Kubik K.... Lange A.	2001	HLA-DRB1, HLA-DRB3
28	Cytokines TNF-alpha and GM-CSF in BAL from two different segments of lungs defined by high resolution computerized tomography (HRCT) in patients with sarcoidosis (11200748)	Ziora D.... Sielska-Pytek E.	2000	TNF
29	Heart failure as a cardiac symptom of sarcoidosis. Successful treatment of heart failure with steroids, digitalis and an angiotensin-1-receptor antagonist in sarcoidosis (10771561)	Oldenburg O.... Weber F.	2000	AGTR1
30	Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients. (11127488)	Niimi T.... Ueda R.	2000	IL1B, IL1RN
31	A probe for evaluating the role of HLA class II antigens coded with the DRB gene in etiopathogenesis of familial sarcoidosis in Poland using the K-nearest neighbor experimental statistical method (11320565)	Goljan A.... Zielinski J.	2000	HLA-DRA, HLA-DRB1
32	Adenosine deaminase activity in bronchoalveolar lavage fluid of sarcoidosis patients (10410539)	Kubota M.... Tomita T.	1999	ADA
33	1,25-dihydroxycholecalciferol stimulates ICAM-1 expression of human alveolar macrophages in healthy controls and patients with sarcoidosis. (10192761)	Braun J.... Dalhoff K.	1999	ICAM1, IFNG
34	Biased T cell receptor Vbeta gene expression in bronchoalveolar lavage fluid from Japanese patients with sarcoidosis. (10612566)	Yoshitomi A.... Koide Y.	1999	TRB@
35	Angiotensin-converting enzyme (ACE) gene polymorphism in patients with sarcoidosis. (9649812)	Garrib A.... Peters T.J.	1998	ACE
36	Molecular studies of bronchial asthma, sarcoidosis and angiotensin converting enzyme inhibitor-induced cough. (9657660)	Kawakami Y.... Matsuda T.	1998	ACE, IGHE
37	A case of sarcoidosis that developed three years after the onset of hard metal asthma. (9513645)	Satoh-Kamachi A.... Kawakami Y.	1998	ACE
38	Fibroblasts as target and effector cells in Japanese patients with sarcoidosis. (9500293)	Tamura R.... Suganuma H.	1998	IL1B, IFNG
39	Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis. (9713444)	Takemoto Y.... Ueda E.	1998	ACE
40	Tumour necrosis factor alpha promoter gene polymorphism in sarcoidosis. (9344512)	Seitzer U.... Gerdes J.	1997	TNF, LTA
41	Cytokine mRNA gene expression in active and nonactive pulmonary sarcoidosis. (9311498)	Minshall E.M.... Hamid Q.	1997	IFNG
42	Serum levels of interleukin-8 as a marker of disease activity in patients with chronic sarcoidosis. (8721898)	Yokoyama T.... Suzuki T.	1995	ACE
43	A case of sarcoidosis with middle lobe atelectasis (7844916)	Amano H.... Matsumoto K.	1994	ACE
44	Adenosine deaminase activity and fibronectin levels in bronchoalveolar lavage fluid in sarcoidosis and tuberculosis. (7907809)	Albera C.... Pozzi E.	1993	ADA, IL2RA, FN1
45	Gastrin-releasing peptide-like immunoreactive substance in bronchoalveolar lavage of idiopathic pulmonary fibrosis and sarcoidosis. (8472833)	Takeyama M.... Izumi T.	1993	GRP
46	Vitronectin in bronchoalveolar lavage--a parameter of disease activity in sarcoidosis (7690172)	Pohl W.R.... KAPhn H.	1993	VTN
47	Serum and urinary neopterin levels in sarcoidosis (8468809)	Terao I.... Horie T.	1993	ACE
48	Evaluation of soluble CD 14 and neopterin as serum parameters of the inflammatory activity of pulmonary sarcoidosis. (1280495)	HOMOLKA J.... Muller-Quernheim J.	1992	CD14
49	A case of sarcoidosis demonstrating spontaneous production of interleukin-1 alpha and beta by alveolar macrophage (2243462)	Sato T.... Kabe J.	1990	IL1A
50	Alpha tumor necrosis factor in the serum of patients with sarcoidosis, tuberculosis or bronchial cancer (2162537)	Theilmann L.... MAPller A.	1990	TNF

Genes related to sarcoidosis according to GeneCards:

(show top 50)    (show all 267)

id	Symbol	Description	Score	GeneCards Section Context
1	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.1	Summaries, Publications
2	SS3	Sarcoidosis, susceptibility to, 3	11.0	Aliases & Descriptions
3	BTNL2	butyrophilin-like 2 (MHC class II associated)	11.0	Publications
4	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
5	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
6	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
7	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
8	IFNG	interferon, gamma	11.0	Publications
9	TNF	tumor necrosis factor	11.0	Publications, Functions
10	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
11	IL9	interleukin 9	11.0	Publications
12	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
13	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
14	IL12RB1	interleukin 12 receptor, beta 1	11.0	Publications
15	SFTPD	surfactant protein D	11.0	Publications
16	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
17	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
18	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
19	CD80	CD80 molecule	11.0	Publications
20	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
21	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
22	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
23	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
24	IL15	interleukin 15	11.0	Publications
25	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
26	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
27	ICAM1	intercellular adhesion molecule 1	11.0	Publications
28	IL1B	interleukin 1, beta	11.0	Publications
29	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
30	TRB@	T cell receptor beta locus	11.0	Publications
31	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
32	HLA-DMA	major histocompatibility complex, class II, DM alpha	11.0	Publications
33	CXCR6	chemokine (C-X-C motif) receptor 6	11.0	Publications
34	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	11.0	Publications
35	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
36	CD27	CD27 molecule	11.0	Publications
37	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
38	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
39	CD69	CD69 molecule	11.0	Publications
40	CD86	CD86 molecule	11.0	Publications
41	DCN	decorin	11.0	Publications
42	IL2RB	interleukin 2 receptor, beta	11.0	Publications
43	CCR4	chemokine (C-C motif) receptor 4	11.0
44	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
45	S100A9	S100 calcium binding protein A9	11.0	Publications
46	ANXA1	annexin A1	11.0	Publications
47	CD14	CD14 molecule	11.0	Publications
48	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
49	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
50	IL1A	interleukin 1, alpha	11.0	Publications

Pathways related to sarcoidosis according to GeneDecks:

(show top 50)    (show all 176)

id	Pathway	Score	Top Affiliating Genes
1	Cytokine-cytokine receptor interaction20	12.6	VEGFA, KDR, CD27, FLT1, IL10, IL12A
2	Chemokine Signaling36	11.7	IL8, MAPK14, CCL4, CCL15, CCR6, CCR2
3	Regulation of eIF4 and p70S6K36	11.7	CD4, CD80, ITGA1, ITGA4, ITGAE, ITGAL
4	Chemokine signaling pathway20	11.6	IL8, CCL4, CCL15, CCR6, CCR2, CCL2
5	Rheumatoid arthritis20	11.6	VEGFA, CD28, CD86, CD80, ITGAL, MMP1
6	Endothelin-1 Signaling Pathway36	11.6	CD80, FLT1, IL10, IL12A, IL12B, IL13
7	PEDF Induced Signaling36	11.5	BCL2L1, CD80, IL10, IL12A, IL12B, IL13
8	Transendothelial Migration of Leukocytes36	11.5	VCAM1, CLDN5, ITGA1, ITGA4, ITGAE, ITGAL
9	Jak-STAT signaling pathway20	11.4	BCL2L1, IL10, IL12A, IL12B, IL12RB1, IL12RB2
10	MIF Mediated Glucocorticoid Regulation36	11.3	CD14, CD80, MIF, IL10, IL12A, IL12B
11	Th1 Differentiation37	11.3	CD28, CD86, CD4, CD80, IL10, IL12A
12	MIF Regulation of Innate Immune Cells36	11.3	CD14, CD80, MIF, IL10, IL12A, IL12B
13	Natural killer cell mediated cytotoxicity20	11.3	KIR2DL3, ITGAL, GZMB, FCGR3A, FASLG, FAS
14	Type I diabetes mellitus20	11.2	CD28, CD86, CD80, GZMB, IL12A, IL12B
15	Glucocorticoid Receptor Signaling36	11.2	CDKN1A, CD4, CD80, IL10, IL12A, IL12B
16	Toll-like receptor signaling pathway20	11.1	CD86, CD14, CD80, IL12A, IL12B, IL1B
17	Cell adhesion molecules (CAMs)20	11.1	SELL, SELP, CLDN5, CD28, CD58, CD86
18	Amoebiasis20	11.1	CD14, ITGAM, FN1, IL12A, IL12B, IL1B
19	Cytokine Network36	11.1	IL10, IL12A, IL12B, IL13, IL15, IL18
20	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.1	GZMA, GZMB, IL15, IL2, IL2RA, IL2RB
21	IL-6 Pathway36	11.1	CD80, IL10, IL12A, IL12B, IL18, IL4
22	JNK Pathway36	11.1	KDR, CD4, CD80, FLT1, IL18R1, IL1R1
23	Viral myocarditis20	11.0	CD28, CD86, CD80, ITGAL, ICAM1, HLA-A
24	Chagas disease (American trypanosomiasis)20	11.0	IL10, IL12A, IL12B, IL1B, IL6, FASLG
25	Malaria20	11.0	SELE, SELP, VCAM1, ITGAL, IL10, IL12A
26	Molecular Mechanisms of Cancer36	10.9	KDR, BCL2L1, AURKC, CDKN1A, CD4, CD80
27	Pertussis20	10.9	CD14, ITGAM, IL10, IL12A, IL12B, IL1A
28	ERK Signaling36	10.9	CD80, ITGA1, ITGA4, ITGAE, ITGAL, ITGAM
29	p38 Signaling36	10.9	KDR, CD28, CD4, CD80, FLT1, IL10
30	Tec Kinases Signaling36	10.9	CD28, CD4, CD80, ITGA1, ITGA4, ITGAE
31	Leishmaniasis20	10.8	ITGA4, ITGAM, FCGR3A, IL10, IL12A, IL12B
32	CDC42 Pathway36	10.8	KDR, ITGA1, ITGA4, ITGAE, ITGAL, ITGAM
33	Graft-versus-host disease20	10.8	KIR2DL3, CD28, CD86, CD80, IL1A, IL2
34	PAK Pathway36	10.8	KDR, CD80, FLT1, IL10, IL12A, IL12B
35	Th17 Differentiation37	10.7	CD28, CD86, CD4, CD80, IL12B, IL12RB1
36	Osteoclast differentiation20	10.7	FCGR3A, IL1A, IL1B, IL1R1, MAPK14, IFNB1
37	Antigen processing and presentation20	10.7	KIR2DL3, CD4, HSPA1A, HSPA1L, HSPA4, HLA-C
38	Staphylococcus aureus infection20	10.7	SELP, ITGAL, ITGAM, FCGR3A, IL10, MBL2
39	Antioxidant Action of Vitamin-C36	10.7	KDR, CD28, CD4, CD80, FLT1, IL10
40	Allograft rejection20	10.7	CD28, CD86, CD80, GZMB, IL10, IL12A
41	CTL Mediated Apoptosis36	10.6	GZMB, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB
42	Toxoplasmosis20	10.6	BCL2L1, IL10, IL12A, IL12B, MAPK14, CCR5
43	TGF-Beta Pathway36	10.5	KDR, CD4, CD80, FLT1, IL10, IL12A
44	Hematopoietic cell lineage20	10.5	CD24, CD14, CD4, CD44, ITGA1, ITGA4
45	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	FOXP3, IL10, IL12A, IL2, IL2RA, IL2RB
46	JAK-STAT Pathway36	10.4	KDR, CD4, CD80, FLT1, IL10, IL12A
47	MAPK Family Pathway36	10.3	KDR, CD4, CD80, FLT1, IL10, IL12A
48	Immune response_MIF-mediated glucocorticoid regulation41	10.2	VCAM1, MMP1, MIF, IL2, IL6, IL8
49	MAPK Signaling36	9.8	KDR, ITGA1, ITGA4, ITGAE, ITGAL, ITGAM
50	NFAT in Immune Response36	9.4	KDR, CD28, CD79A, CD86, CD4, CD80

Compounds related to sarcoidosis according to GeneDecks:

(show top 50)    (show all 450)

id	Compound	Score	Top Affiliating Genes
1	il 1032	11.6	VDR, IL10, IL12B, IL13, IL15, IL18
2	tarc32	11.3	CD4, ITGA4, IL10, IL13, IL18, IL1A
3	leukotriene b432 42 18	13.3	SELL, SELP, ITGAL, ITGAM, MMP9, FCER2
4	mip 1alpha32	11.2	IL10, IL13, IL1B, IL4, IL6, IL8
5	atp32	11.2	PIK3C2A, VTN, VIM, BCL2L1, LBR, S100A9
6	ifn-alpha32	11.1	IL10, IL13, IL18, IL2, IL2RA, IL2RB
7	fitc32	11.1	SELL, CD86, CD14, CD4, ITGAL, ITGAM
8	mycophenolic acid32 9 9	13.0	IL2
9	gp 13032	10.9	BCL2L1, SCGB1A1, IL12RB1, IL13, IL15, IL18R1
10	heparin32 9 18 9	13.8	PIK3C2A, VTN, SERPINA3, VIM, CMA1, CLEC12A
11	mannose32	10.8	SFTPD, CLEC12A, CHIT1, MRC1, CD79A, CD69
12	cyclic amp32 18	11.8	SFTPD, LBR, CFTR, CD28, ITGA4, ITGAL
13	imiquimod32 42 9 9	13.7	IL10, IL12B, IL18, IL1A, IL1RAPL2, IL5
14	egcg32	10.6	BCL2L1, IL1A, MAPK14, CCL5, NFKBIA, ELANE
15	polysulfone32	10.5	SELL, SELP, VCAM1, B2M, CD14, ITGAM
16	neopterin32	10.4	CHIT1, LBR, B2M, CD79A, CD14, CD4
17	heparan sulfate32 18	11.4	VTN, VIM, KDR, B2M, CD4, CD44
18	phosphatidylserine32 9 9	12.4	SELE, VIM, P2RX7, CD79A, CD14, GZMB
19	pmma32	10.3	VTN, SELP, B2M, FN1, CCL3, CCL5
20	auranofin32 9 9	12.3	SELE, IL1A, IL1B, IL2, IL2RB, IFNG
21	calcitriol32 42 9 18 9	14.2	VDR, S100A8, S100A9, B2M, CDKN1A, CD14
22	phorbol32	10.1	SELL, CDKN1A, CD69, CD4, ITGAL, ITGAM
23	mg 13232 42	11.1	VDR, KDR, BCL2L1, CFTR, CDKN1A, IL1A
24	resveratrol32 9 18 9	13.1	VEGFA, VDR, BCL2L1, CDKN1A, CD14, MMP9
25	s-nitroso-n-acetylpenicillamine32	10.1	FN1, IL1B, IL8, ANXA5, MAPK14, IFNG
26	thalidomide32 42 9 9	13.0	VTN, SELL, VEGFA, KDR, BCL2L1, B2M
27	citrate32	10.0	PIK3C2A, SELP, VDR, CFTR, CD79A, HSPA1A
28	cytarabine32 34 9 9	12.9	VIM, BCL2L1, CDKN1A, CD80, GZMB, FASLG
29	1,25 dihydroxy vitamin d332	9.8	VDR, S100A9, CD14, CD4, IL18, IL1A
30	aprotinin32 9 9	11.7	SELP, MMP9, FN1, IL1A, IGF1, IGHE
31	sulfasalazine32 9 9	11.7	SELE, CD79A, IL12B, IL1A, IL1B, IL1R1
32	etanercept32 9 9	11.6	MMP1, MMP12, FCGR3A, IL10, IL15, IL18
33	prednisolone32 9 9	11.6	PIK3C2A, SFTPD, SELL, VCAM1, CD79A, CD14
34	cyclosporin a32 42	10.5	PIK3C2A, SELP, VDR, LBR, P2RX7, B2M
35	p00232	9.5	SCGB1A1, CD14, CD44, ITGAM, MMP7, MMP8
36	fibrinogen32	9.5	PIK3C2A, VTN, SELE, SELP, SERPINA3, VCAM1
37	doxorubicin32 34 9 9	12.4	PIK3C2A, SELE, VIM, KDR, BCL2L1, B2M
38	paclitaxel32 34 9 9	12.3	VIM, VEGFA, KDR, BCL2L1, CDKN1A, CD44
39	n acetylcysteine32	9.3	SELE, SELP, VCAM1, KDR, CFTR, CD79A
40	valine32	9.3	SERPINA3, VIM, B2M, CFTR, GSTP1, FCGR3A
41	amphotericin b32	9.2	IL13, IL1R1, IL1RAPL2, IL1RN, IL4, IL5
42	cytochalasin d32 42	10.2	VTN, SELE, SELL, VIM, VCAM1, CFTR
43	prostaglandin32	9.2	VIM, MMP1, MMP7, MMP9, IL18R1, IL1A
44	dexamethasone32 42 34 9 9	13.2	VTN, SFTPD, SELL, SELP, SERPINA3, VIM
45	cysteine32	9.1	VTN, SFTPD, RCVRN, SELP, SERPINA3, VDR
46	glutamate32	9.0	VTN, VIM, VDR, KDR, S100A8, P2RX7
47	8-isoprostane32	9.0	SELE, VCAM1, MMP9, IL10, IL6, IL8
48	cholesterol32 9 18 9	12.0	PIK3C2A, VTN, SFTPD, SELE, SELP, SERPINA3
49	arginine32	8.5	PIK3C2A, VTN, SERPINA3, VDR, LBR, KARS
50	methotrexate32 34 42 9 9	12.3	PIK3C2A, SELE, SERPINA3, VIM, MT2A, S100A8

Cellular components related to sarcoidosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	11.5	IL4, PTPRC, CTLA4, CTSB, ACE, TLR2
2	integral to plasma membrane	GO:005887	11.2	FLT1, FCER2, IL12RB2, IL15, IL1R1, IL2RB
3	cell surface	GO:009986	11.2	VEGFA, VCAM1, CD24, NOD2, PDGFB, ACE2
4	MHC class II protein complex	GO:042613	10.7	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
5	clathrin-coated endocytic vesicle membrane	GO:030669	10.6	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-G, HLA-DRA
7	trans-Golgi network membrane	GO:032588	10.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
8	endocytic vesicle membrane	GO:030666	10.4	RPS27A, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA
9	ER to Golgi transport vesicle membrane	GO:012507	10.4	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-G, HLA-DRA
10	transport vesicle membrane	GO:030658	10.2	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
11	plasma membrane	GO:005886	10.1	PIK3C2A, KIR2DL3, PCDHGC3, SELE, SELL, SELP
12	membrane raft	GO:045121	10.0	TNF, TNFRSF1A, TNFRSF1B, PTPRC, ACE2, TLR4
13	platelet alpha granule lumen	GO:031093	9.4	TGFB2, TGFB1, TIMP1, PDGFB, ALB, IGF1
14	extracellular space	GO:005615	9.0	CRP, DCN, CX3CL1, CXCL10, CXCL5, CXCL9
15	extracellular region	GO:005576	7.3	IFNB1, CRP, COL1A1, COL3A1, NGF, PDGFB

Biological processes related to sarcoidosis according to GeneDecks:

(show top 50)    (show all 88)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	12.3	MAPK14, IL4, S100A9, S100A8, DEFB4A, CCL17
2	cell-cell signaling	GO:007267	12.3	CCL4, CCL15, CCR5, CCL17, CCL23, CCL3
3	cell surface receptor signaling pathway	GO:007166	11.6	SST, EDN1, EDN3, CXCL10, NPPB, C5
4	positive regulation of interferon-gamma production	GO:032729	11.5	TNF, LTA, IL2, IL1B, CCR2, IL18
5	positive regulation of T cell proliferation	GO:042102	11.4	CD28, VCAM1, ITGAL, IL12A, IL12B, IL15
6	immune response	GO:006955	11.4	CCL4, CCR5, CCL17, CCL25, CCL23, CCL18
7	signal transduction	GO:007165	11.3	S100A9, ANXA1, MAPK14, CCL4, CCL15, CCR6
8	lipopolysaccharide-mediated signaling pathway	GO:031663	11.2	CCL5, STAT1, TGFB1, TLR4, MAPK14, IL1B
9	neutrophil chemotaxis	GO:030593	11.2	TGFB2, ITGA1, IL1B, IL8, CCL2, CCL3
10	cellular response to lipopolysaccharide	GO:071222	11.1	TLR4, NOS2, CCL2, IL8, IL12B, GSTP1
11	response to virus	GO:009615	11.1	IFNG, ENO1, FOXP3, IL12A, CCL4, CCL11
12	activation of MAPK activity	GO:000187	11.1	PTPRC, C5, TGFB3, SOD1, CXCR4, ITGA1
13	negative regulation of T cell proliferation	GO:042130	11.1	SCGB1A1, SFTPD, IL10, FOXP3, HLA-DRB1, HLA-DRB3
14	elevation of cytosolic calcium ion concentration	GO:007204	11.1	AGTR1, TACR1, TAC1, CXCR3, CXCR4, CCR2
15	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.1	CHI3L1, MIF, CD44, IL1A, IL1B, CCL3
16	cellular calcium ion homeostasis	GO:006874	11.0	C5, VDR, CCL15, CCR2, CCL3, ELANE
17	positive regulation of tumor necrosis factor production	GO:032760	11.0	CCL3, IFNG, IL12B, CD14, IL18, NOD1
18	negative regulation of growth of symbiont in host	GO:044130	11.0	CAMP, TNF, IL10, IFNG, TLR2, MBL2
19	interferon-gamma-mediated signaling pathway	GO:060333	10.9	ICAM1, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1
20	defense response to bacterium	GO:042742	10.9	CAMP, LYZ, SLC11A1, DEFB4A, DEFB1, TLR4
21	positive regulation of inflammatory response	GO:050729	10.9	AGTR1, CX3CL1, TLR2, TNFRSF1A, CCL3, CCR2
22	T cell costimulation	GO:031295	10.8	CTLA4, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
23	aging	GO:007568	10.8	CCL2, CCL5, FAS, IL1B, ADA, IL15
24	response to ethanol	GO:045471	10.8	TACR1, SOD1, MMP9, CCL2, TLR4, CTSB
25	detection of bacterium	GO:016045	10.8	HLA-DRB4, NOD1, HLA-DRB5, HLA-DRB1, HLA-B, HLA-A
26	cytokine-mediated signaling pathway	GO:019221	10.8	IL2RB, IL5, IL6, CCR2, CCL2, IFNA10
27	defense response to Gram-negative bacterium	GO:050829	10.7	CAMP, MMP7, IL12B, SELP, NOS2, TLR4
28	T-helper 1 type immune response	GO:042088	10.7	IL18, HLA-DRB5, HLA-DRB4, HLA-DRB3, TLR4, HLA-DRB1
29	type I interferon-mediated signaling pathway	GO:060337	10.7	HLA-B, STAT1, IFNA17, HLA-G, IRF4, IFNA10
30	positive regulation of interleukin-6 production	GO:032755	10.7	P2RX7, IL1A, IL1B, TNF, NOD1, NOD2
31	response to drug	GO:042493	10.7	TGFB2, TGIF1, SOD1, NPPB, ANXA1, CCL2
32	defense response to Gram-positive bacterium	GO:050830	10.6	MMP7, P2RX7, IL12A, IL6, MBL2, CAMP
33	regulation of immune response	GO:050776	10.6	ITGA4, KIR2DL3, SELL, C3, B2M, ITGAL
34	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.6	IRF4, IL1A, CD80, CD86, CD28, CD4
35	response to hypoxia	GO:001666	10.5	LTA, PDGFB, NOS2, CRP, PYGM, TNFRSF1A
36	inflammatory response	GO:006954	10.5	CCR4, PTGS2, CYBB, SPP1, CRP, NOD1
37	innate immune response	GO:045087	10.4	IGHG1, IGKC, IFNA10, IFNA17, IFNA2, IFNB1
38	response to lipopolysaccharide	GO:032496	10.4	DCN, SELE, SELP, S100A8, S100A9, P2RX7
39	cellular response to interleukin-1	GO:071347	10.2	MMP9, CHI3L1, IL8, CCL2, CCL3, EDN1
40	response to radiation	GO:009314	10.2	TGFB2, MMP9, IL18, CCL11, TXN, NR3C1
41	T cell receptor signaling pathway	GO:050852	10.1	CD4, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3
42	positive regulation of angiogenesis	GO:045766	10.1	IL1B, HMOX1, C5, CCL5, CCL11, CX3CL1
43	virus-host interaction	GO:019048	10.0	CD80, HLA-A, CCR5, ANPEP, IL2RB, MMP1
44	cellular component movement	GO:006928	9.9	IGF1, CCR6, CCL4, MAPK14, ANXA1, IL8
45	positive regulation of smooth muscle cell proliferation	GO:048661	9.8	TNF, PTGS2, PDGFB, EDN1, ELANE, STAT1
46	positive regulation of cell proliferation	GO:008284	9.6	GLI1, CSF2, CSF3, FASLG, PDGFB, NGF
47	blood coagulation	GO:007596	9.6	ALB, NOS2, IFNB1, IFNA2, PDGFB, TGFB2
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.4	IL2, VEGFA, IL4, IL1B, IL1A, GREM1
49	anti-apoptosis	GO:006916	9.1	ANXA5, FAS, IL2, IL1B, IL10, GSTP1
50	platelet degranulation	GO:002576	8.9	SOD1, VEGFA, TGFB2, TF, SELP, FN1

Molecular functions related to sarcoidosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.4	C5, CCL2, CCL15, CCL4, IL8, CCL11
2	cytokine activity	GO:005125	11.2	IL10, GREM1, MIF, VEGFA, IL12A, CSF3
3	heparin binding	GO:008201	10.8	ELANE, LTF, PTPRC, CCL5, CCL23, CCL2
4	coreceptor activity	GO:015026	10.6	CXCR4, CCR5, CD80, CD4, CD86, CD28
5	receptor binding	GO:005102	10.4	TGFB2, EDN3, LTA, NOS2, TNC, PRDX5
6	MHC class II receptor activity	GO:032395	10.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
7	growth factor activity	GO:008083	9.2	NGF, PDGFB, TGFB1, TGFB2, TGFB3, CSF1
8	protein homodimerization activity	GO:042803	8.8	TGFB2, TGFB1, TKT, G6PD, PDGFB, NFKB1
9	protein binding	GO:005515	7.1	STAT1, TAP2, TAP1, TACR1, TF, DPEP1