MCID: SRC025
MIFTS: 63

Sarcoidosis 1

Categories: Genetic diseases, Rare diseases, Immune diseases, Neuronal diseases, Eye diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Endocrine diseases

Aliases & Classifications for Sarcoidosis 1

MalaCards integrated aliases for Sarcoidosis 1:

Name: Sarcoidosis 1 53 71
Sarcoidosis 53 12 72 49 55 71 51 40 69 41 14 59
Boeck Sarcoid 53 12 55 71
Sarcoidosis, Susceptibility to, 1 53 13
Besnier-Boeck-Schaumann Disease 55 71
Ss1 53 71
Lymphogranulomatosis 12
Schaumann's Disease 49
Sarcoid of Boeck 49
Hodgkin Disease 69
Boeck's Sarcoid 55

Characteristics:

Orphanet epidemiological data:

55
sarcoidosis
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000 (Worldwide),1-5/10000 (Europe); Age of onset: Adult;

OMIM:

53
Miscellaneous:
generalized fatigue
onset usually before age 40 years
systemic granulomatous disease
u.s. frequency higher in blacks than whites

Inheritance:
autosomal dominant


HPO:

31
sarcoidosis 1:
Inheritance sporadic


Classifications:



Summaries for Sarcoidosis 1

NIH Rare Diseases : 49 Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. If these tiny granulomas grow and clump together in an organ, they can affect the organ's structure and function. Overtime, this can lead to permanent scarring or thickening of the organ tissue (also called fibrosis). Although the granulomas can be found in almost any part of the body, they occur most commonly in the lungs and lymph nodes. Signs and symptoms of sarcoidosis vary based on the location of the granulomas and the severity of the condition. The exact cause of sarcoidosis is poorly understood. In many cases, treatment is not necessary and sarcoidosis will resolve on its own. However, therapies such as corticosteroids, immunosuppressants, and antimalarial drugs, are available to control symptoms, prevent complications, and improve outcomes. Last updated: 4/16/2017

MalaCards based summary : Sarcoidosis 1, also known as sarcoidosis, is related to peritonitis and pulmonary sarcoidosis, and has symptoms including fatigue, dyspnea and fever. An important gene associated with Sarcoidosis 1 is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, skin and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

OMIM : 53 Idiopathic scoliosis is a structurally fixed lateral curvature of the spine with a rotatory component. There is at least a 10 degree curvature as demonstrated by upright spine roentgenograms by the Cobb method (Weinstein, 1994). (181000)

UniProtKB/Swiss-Prot : 71 Sarcoidosis 1: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.

MedlinePlus : 40 Sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. It starts as tiny, grain-like lumps, called granulomas. Sarcoidosis can affect any organ in your body. No one is sure what causes sarcoidosis. It affects men and women of all ages and races. It occurs mostly in people ages 20 to 50, African Americans, especially women, and people of Northern European origin. Many people have no symptoms. If you have symptoms, they may include Cough Shortness of breath Weight loss Night sweats Fatigue Tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. Not everyone who has the disease needs treatment. If you do, prednisone, a type of steroid, is the main treatment. NIH: National Heart, Lung, and Blood Institute

Disease Ontology : 12 A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.

PubMed Health : 59
About sarcoidosis: Sarcoidosis (sar-koy-DO-sis) is a disease of unknown cause that leads to inflammation. This disease affects your body’s organs.Normally, your immune system defends your body against foreign or harmful substances. For example, it sends special cells to protect organs that are in danger.These cells release chemicals that recruit other cells to isolate and destroy the harmful substance. Inflammation occurs during this process. Once the harmful substance is gone, the cells and the inflammation go away.In people who have sarcoidosis, the inflammation doesn't go away. Instead, some of the immune system cells cluster to form lumps called granulomas (gran-yu-LO-mas) in various organs in your body.

Wikipedia : 72 Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as... more...

Related Diseases for Sarcoidosis 1

Diseases in the Sarcoidosis 1 family:

Sarcoidosis 2 Sarcoidosis 3

Diseases related to Sarcoidosis 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.3 CCL2 ICAM1 IFNG IL1B TNF
2 pulmonary sarcoidosis 29.2 ACE CCL2 CXCR3 ICAM1 IFNG IL18
3 sarcoidosis 2 11.2
4 angioimmunoblastic t-cell lymphoma 11.1
5 chronic beryllium disease 10.7 HLA-DRB1 IFNG TNF
6 granulomatous dermatitis 10.7 ACE NOD2 TNF
7 microscopic colitis 10.7 HLA-DRB1 IFNG TNF
8 nontuberculous mycobacterial lung disease 10.7 HLA-DRB1 SLC11A1 TNF
9 polyposis, gastric 10.7 IL1B TNF
10 hemorrhagic fever 10.6 HLA-DRB1 IFNG TNF
11 rheumatoid factor-negative juvenile idiopathic arthritis 10.6 HLA-DRB1 IL2RA SLC11A1
12 ileocolitis 10.6 IL2RA NOD2 TNF
13 rheumatic heart disease 10.6 ACE HLA-DRB1 TNF
14 inflammatory bowel disease 3 10.6 IL18 NOD2 TNF
15 staphylococcal toxic shock syndrome 10.6 IFNG IL1B TNF
16 mixed connective tissue disease 10.6 HLA-DRB1 IFNG TNF
17 posterior uveitis 10.6 IFNG IL2RA TNF
18 meconium aspiration syndrome 10.6 IFNG SCGB1A1 TNF
19 systemic onset juvenile idiopathic arthritis 10.6 IL18 IL1B TNF
20 echinococcosis 10.6 HLA-DRB1 IFNG TNF
21 dengue hemorrhagic fever 10.6 HLA-DRB1 IFNG TNF
22 hyperlucent lung 10.6 IFNG IL2RA
23 palindromic rheumatism 10.6 HLA-DRB1 IL1B TNF
24 commensal bacterial infectious disease 10.6 BTNL2 IL1B TNF
25 blau syndrome 10.6 IL1B NOD2 TNF
26 sympathetic ophthalmia 10.6 HLA-DRB1 LTA TNF
27 campylobacteriosis 10.6 IFNG IL1B SLC11A1
28 ischemic heart disease 10.6 ACE CCL2 TNF
29 eales disease 10.6 IFNG IL1B TNF
30 rasmussen encephalitis 10.6 IFNG IL18 TNF
31 aseptic meningitis 10.6 IFNG IL1B TNF
32 hidradenitis suppurativa 10.6 IL12RB1 NOD2 TNF
33 paracoccidioidomycosis 10.6 IFNG IL18 TNF
34 subacute cutaneous lupus erythematosus 10.6 ACE TNF
35 hidradenitis 10.6 IL12RB1 NOD2 TNF
36 q fever 10.6 IFNG IL1B TNF
37 mumps 10.6 HLA-DRB1 IFNG IL2RA
38 pulpitis 10.6 IL18 IL1B TNF
39 melioidosis 10.6 IFNG IL18 TNF
40 poliomyelitis 10.6 ICAM1 IFNG TNF
41 filariasis 10.6 CHIT1 IFNG TNF
42 listeria meningitis 10.6 IL18 LTA TNF
43 smallpox 10.6 IFNG IL18 TNF
44 chikungunya 10.6 IL18 IL1B TNF
45 post-transplant lymphoproliferative disease 10.6 LTA SLC11A1 TNF
46 plasmodium vivax malaria 10.6 ICAM1 IFNG TNF
47 type 1 diabetes mellitus 12 10.6 HLA-DRB1 SLC11A1
48 optic neuritis 10.6 HLA-DRB1 LTA TNF
49 cutaneous leishmaniasis 10.5 IFNG SLC11A1 TNF
50 central nervous system vasculitis 10.5 HLA-DRB1 IFNG IL1B TNF

Graphical network of the top 20 diseases related to Sarcoidosis 1:



Diseases related to Sarcoidosis 1

Symptoms & Phenotypes for Sarcoidosis 1

Symptoms via clinical synopsis from OMIM:

53
Respiratory:
dyspnea
cough

HeadAndNeckEyes:
photophobia
blurred vision
glaucoma
uveitis
enlarged lacrimal glands
more
AbdomenGastrointestinal:
anorexia
associated inflammatory bowel disease

Immunology:
exaggerated cellular immune processes
generalized lymphadenopathy
hyperglobulinemia
activated t-helper cells
activated mononuclear phagocytes

RespiratoryLung:
bilateral hilar adenopathy
pulmonary parenchymal infiltration
pulmonary function tests show interstitial lung disease

AbdomenSpleen:
splenomegaly may occur

NeurologicCentralNervousSystem:
neurosarcoidosis (5-16% of patients)

MetabolicFeatures:
fever

GrowthWeight:
weight loss

LaboratoryAbnormalities:
hypercalciuria
elevated erythrocyte sedimentation rate (esr)
elevated serum angiotensin-converting enzyme (ace)
positive kveim-siltzbach skin test
mononuclear cell noncaseating granulomatous inflammation on biopsy (lung, skin, lip)

HeadAndNeckMouth:
enlarged salivary glands

AbdomenLiver:
hepatomegaly may occur
elevated liver function tests may occur

Skeletal:
polyarthritis
bone cysts

Hematology:
bone marrow involvement may cause pancytopenia


Clinical features from OMIM:

181000

Human phenotypes related to Sarcoidosis 1:

55 31 (show top 50) (show all 92)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 55 31 frequent (33%) Frequent (79-30%) HP:0012378
2 dyspnea 55 31 frequent (33%) Frequent (79-30%) HP:0002094
3 fever 55 31 frequent (33%) Frequent (79-30%) HP:0001945
4 hemoptysis 55 31 very rare (1%) Very rare (<4-1%) HP:0002105
5 chest pain 55 31 frequent (33%) Frequent (79-30%) HP:0100749
6 joint swelling 55 31 frequent (33%) Frequent (79-30%) HP:0001386
7 hypothyroidism 55 31 very rare (1%) Very rare (<4-1%) HP:0000821
8 hypothermia 55 31 very rare (1%) Very rare (<4-1%) HP:0002045
9 facial palsy 55 31 occasional (7.5%) Occasional (29-5%) HP:0010628
10 cataract 55 31 occasional (7.5%) Occasional (29-5%) HP:0000518
11 hepatomegaly 55 31 occasional (7.5%) Occasional (29-5%) HP:0002240
12 blindness 55 31 occasional (7.5%) Occasional (29-5%) HP:0000618
13 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
14 portal hypertension 55 31 occasional (7.5%) Occasional (29-5%) HP:0001409
15 subcutaneous nodule 55 31 occasional (7.5%) Occasional (29-5%) HP:0001482
16 pulmonary fibrosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002206
17 emphysema 55 31 occasional (7.5%) Occasional (29-5%) HP:0002097
18 hemolytic anemia 55 31 very rare (1%) Very rare (<4-1%) HP:0001878
19 weight loss 55 31 frequent (33%) Frequent (79-30%) HP:0001824
20 peripheral neuropathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0009830
21 alopecia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001596
22 thrombocytopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001873
23 hyperthyroidism 55 31 very rare (1%) Very rare (<4-1%) HP:0000836
24 hypercalciuria 55 31 occasional (7.5%) Occasional (29-5%) HP:0002150
25 heart block 55 31 occasional (7.5%) Occasional (29-5%) HP:0012722
26 keratoconjunctivitis sicca 55 31 occasional (7.5%) Occasional (29-5%) HP:0001097
27 diabetes insipidus 55 31 occasional (7.5%) Occasional (29-5%) HP:0000873
28 glaucoma 55 31 occasional (7.5%) Occasional (29-5%) HP:0000501
29 nephrocalcinosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000121
30 nephrolithiasis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000787
31 hypercalcemia 55 31 occasional (7.5%) Occasional (29-5%) HP:0003072
32 cough 55 31 frequent (33%) Frequent (79-30%) HP:0012735
33 hepatic failure 55 31 occasional (7.5%) Occasional (29-5%) HP:0001399
34 abnormality of the gastrointestinal tract 55 31 occasional (7.5%) Occasional (29-5%) HP:0011024
35 lymphadenopathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0002716
36 bone cyst 55 31 occasional (7.5%) Occasional (29-5%) HP:0012062
37 abnormality of the adrenal glands 55 31 very rare (1%) Very rare (<4-1%) HP:0000834
38 bronchiectasis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002110
39 uveitis 55 31 frequent (33%) Frequent (79-30%) HP:0000554
40 eosinophilia 55 31 very rare (1%) Very rare (<4-1%) HP:0001880
41 pneumothorax 55 31 occasional (7.5%) Occasional (29-5%) HP:0002107
42 upper airway obstruction 55 31 occasional (7.5%) Occasional (29-5%) HP:0002781
43 leukopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001882
44 proximal muscle weakness 55 31 occasional (7.5%) Occasional (29-5%) HP:0003701
45 chylothorax 55 31 occasional (7.5%) Occasional (29-5%) HP:0010310
46 tubulointerstitial nephritis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001970
47 erythema nodosum 55 31 frequent (33%) Frequent (79-30%) HP:0012219
48 increase in t cell count 55 31 frequent (33%) Frequent (79-30%) HP:0100828
49 abnormality of the nasal mucosa 55 31 occasional (7.5%) Occasional (29-5%) HP:0000433
50 dacryocystitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000620

UMLS symptoms related to Sarcoidosis 1:


snoring, coughing

GenomeRNAi Phenotypes related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 LTA NOD2 TNF ACE ICAM1 IL18
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 LTA NOD2 TNF ACE ICAM1 IL18

MGI Mouse Phenotypes related to Sarcoidosis 1:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 TNF IL18 IL1B IL2RA ACE LTA
2 homeostasis/metabolism MP:0005376 9.97 IL12RB1 TNF IL18 IL1B IL2RA ACE
3 immune system MP:0005387 9.86 IL18 IL1B IL2RA ACE LTA CCL2
4 neoplasm MP:0002006 9.28 TNF IL1B ACE MIF CXCR3 ICAM1

Drugs & Therapeutics for Sarcoidosis 1

PubMedHealth treatment related to Sarcoidosis 1: 59

Not everyone who has sarcoidosis needs treatment. Sometimes the disease goes away on its own. Whether you need treatment and what type of treatment you need depend on your signs and symptoms, which organs are affected, and whether those organs are working well.If the disease affects certain organs—such as your eyes, heart, or brain—you'll need treatment even if you don't have any symptoms.In either case, whether you have symptoms or not, you should see your doctor for ongoing care. He or she will want to check to make sure that the disease isn't damaging your organs. For example, you may need routine lung function tests to make sure that your lungs are working well.If the disease isn't worsening, your doctor may watch you closely to see whether the disease goes away on its own. If the disease does start to get worse, your doctor can prescribe treatment.The goals of treatment include:Relieving symptomsImproving organ functionControlling inflammation and reducing the size of granulomas (inflamed lumps)Preventing pulmonary fibrosis (lung scarring) if your lungs are affectedYour doctor may prescribe topical treatments and/or medicines to treat the disease.

Search Clinical Trials , NIH Clinical Center for Sarcoidosis 1

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: sarcoidosis

Genetic Tests for Sarcoidosis 1

Anatomical Context for Sarcoidosis 1

MalaCards organs/tissues related to Sarcoidosis 1:

38
Lung, Skin, Lymph Node, Liver, Heart, Eye, Testes

Publications for Sarcoidosis 1

Articles related to Sarcoidosis 1:

# Title Authors Year
1
Sarcoidosis. 1. ( 5059500 )
1972
2
Pulmonary sarcoidosis. 1. Pathophysiologic correlations. ( 5649858 )
1968
3
Sarcoidosis. 1. Ultrastructural investigations on epithelioid cell granulomas. ( 5955900 )
1966

Variations for Sarcoidosis 1

ClinVar genetic disease variations for Sarcoidosis 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HLA-DRB1 HLA-DRB1, HLA-DRB1*1101 undetermined variant risk factor

Expression for Sarcoidosis 1

Search GEO for disease gene expression data for Sarcoidosis 1.

Pathways for Sarcoidosis 1

Pathways related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 BTNL2 CCL2 CCL3 CHIT1 HLA-DRB1 ICAM1
2
Show member pathways
13.85 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
3
Show member pathways
13.71 CCL2 CCL3 CXCR3 IFNG IL12RB1 IL18
4
Show member pathways
13.6 CCL2 CCL3 ICAM1 IFNG IL12RB1 IL18
5
Show member pathways
13.47 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
6
Show member pathways
13.36 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
7
Show member pathways
13.32 CCL2 CCL3 HLA-DRB1 ICAM1 IFNG IL12RB1
8
Show member pathways
12.92 HLA-DRB1 ICAM1 IFNG IL1B IL2RA LTA
9
Show member pathways
12.8 CCL2 HLA-DRB1 ICAM1 IFNG IL18 IL1B
10
Show member pathways
12.7 HLA-DRB1 IFNG IL12RB1 IL18 IL2RA TNF
11
Show member pathways
12.67 CCL2 IFNG IL12RB1 IL18 IL1B TNF
12
Show member pathways
12.63 HLA-DRB1 IFNG IL12RB1 IL18 IL1B IL2RA
13 12.61 CCL2 IFNG IL1B IL2RA TNF
14
Show member pathways
12.61 ACE CCL2 CCL3 IFNG IL1B TNF
15 12.5 HLA-DRB1 ICAM1 IL2RA LTA TNF
16
Show member pathways
12.41 CCL2 ICAM1 IFNG IL1B TNF
17
Show member pathways
12.36 CCL2 IFNG IL1B TNF
18
Show member pathways
12.31 IFNG IL1B MIF TNF
19 12.31 HLA-DRB1 IFNG IL18 IL1B NOD2 TNF
20
Show member pathways
12.29 HLA-DRB1 IFNG IL1B TNF
21
Show member pathways
12.23 IFNG IL18 IL1B LTA TNF
22 12.17 CCL2 ICAM1 IFNG IL1B TNF
23 12.1 CCL2 ICAM1 IFNG IL1B MIF TNF
24 12.07 CCL2 ICAM1 IL18 IL1B TNF
25 12.03 CCL2 ICAM1 IL1B LTA NOD2 TNF
26
Show member pathways
12 IFNG IL12RB1 IL18 IL1B LTA TNF
27 11.99 CCL2 ICAM1 IL1B TNF
28 11.97 HLA-DRB1 IL1B IL2RA TNF
29
Show member pathways
11.97 CCL3 HLA-DRB1 IFNG IL12RB1 IL18 IL1B
30 11.96 ICAM1 IL1B LTA TNF
31 11.91 CCL3 IFNG IL18 IL1B
32
Show member pathways
11.86 IFNG IL12RB1 IL1B
33
Show member pathways
11.78 IFNG IL2RA TNF
34 11.78 ICAM1 IL2RA LTA TNF
35 11.77 IFNG IL1B TNF
36
Show member pathways
11.76 ICAM1 IFNG IL1B MIF TNF
37 11.75 CCL2 CCL3 IL1B TNF
38
Show member pathways
11.68 IFNG IL2RA TNF
39 11.63 IL18 IL1B TNF
40 11.62 CCL2 IFNG IL18 IL1B TNF
41
Show member pathways
11.58 IFNG LTA TNF
42 11.56 IFNG IL1B TNF
43 11.53 IFNG IL1B TNF
44 11.51 CCL2 CCL3 HLA-DRB1 ICAM1 IFNG IL18
45 11.49 IL18 IL1B NOD2
46 11.49 CCL2 CCL3 ICAM1 IL18 IL1B TNF
47
Show member pathways
11.47 CCL3 IFNG IL2RA TNF
48 11.44 ICAM1 IFNG IL1B
49 11.42 ICAM1 IFNG IL18 IL1B TNF
50 11.42 CCL2 ICAM1 IFNG IL18 IL1B TNF

GO Terms for Sarcoidosis 1

Cellular components related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.72 ACE CHIT1 HLA-DRB1 IL1B SLC11A1
2 cell surface GO:0009986 9.7 CXCR3 HLA-DRB1 ICAM1 IL2RA MIF NOD2
3 external side of plasma membrane GO:0009897 9.43 ACE CXCR3 HLA-DRB1 ICAM1 IL2RA TNF
4 extracellular space GO:0005615 9.4 ACE CCL2 CCL3 CHIT1 ICAM1 IFNG
5 extracellular region GO:0005576 10 ACE CCL2 CCL3 CHIT1 IFNG IL18

Biological processes related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 CCL2 CCL3 IL18 IL1B IL2RA TNF
2 regulation of receptor activity GO:0010469 9.97 CCL2 CCL3 IFNG IL18 IL1B LTA
3 positive regulation of protein phosphorylation GO:0001934 9.96 IFNG IL1B MIF TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 ICAM1 IL1B NOD2 TNF
5 response to lipopolysaccharide GO:0032496 9.93 ICAM1 IL1B LTA SCGB1A1 SLC11A1
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 CCL3 ICAM1 MIF NOD2 TNF
7 cellular response to interleukin-1 GO:0071347 9.89 CCL2 CCL3 ICAM1
8 chemokine-mediated signaling pathway GO:0070098 9.89 CCL2 CCL3 CXCR3
9 regulation of inflammatory response GO:0050727 9.89 NOD2 SCGB1A1 TNF
10 positive regulation of JNK cascade GO:0046330 9.88 IL1B NOD2 TNF
11 interferon-gamma-mediated signaling pathway GO:0060333 9.88 HLA-DRB1 ICAM1 IFNG
12 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
13 neutrophil chemotaxis GO:0030593 9.87 CCL2 CCL3 IL1B
14 positive regulation of MAP kinase activity GO:0043406 9.86 MIF NOD2 TNF
15 positive regulation of T cell proliferation GO:0042102 9.86 BTNL2 IL1B IL2RA
16 cellular response to interferon-gamma GO:0071346 9.86 CCL2 CCL3 ICAM1 IL12RB1
17 interleukin-12-mediated signaling pathway GO:0035722 9.85 IFNG IL12RB1 MIF
18 positive regulation of tumor necrosis factor production GO:0032760 9.83 CCL3 MIF NOD2
19 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B NOD2 TNF
20 humoral immune response GO:0006959 9.81 CCL2 IFNG LTA TNF
21 inflammatory response GO:0006954 9.81 CCL2 CCL3 CXCR3 IL18 IL1B IL2RA
22 negative regulation of T cell proliferation GO:0042130 9.8 HLA-DRB1 IL2RA SCGB1A1
23 response to bacterium GO:0009617 9.79 CCL2 CHIT1 SLC11A1
24 positive regulation of phagocytosis GO:0050766 9.79 IL1B SLC11A1 TNF
25 protein kinase B signaling GO:0043491 9.78 CCL2 CCL3 IL1B TNF
26 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B NOD2 TNF
27 positive regulation of activated T cell proliferation GO:0042104 9.77 IL12RB1 IL18 IL2RA
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 ICAM1 IFNG IL1B TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.74 IL18 IL1B TNF
30 macrophage chemotaxis GO:0048246 9.73 CCL2 CCL3
31 positive regulation of interleukin-17 production GO:0032740 9.73 IL18 NOD2
32 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 CCL3 IL18 IL1B NOD2 TNF
33 inflammatory response to antigenic stimulus GO:0002437 9.72 HLA-DRB1 IL2RA
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
35 T cell chemotaxis GO:0010818 9.72 CCL3 CXCR3
36 T-helper 1 type immune response GO:0042088 9.72 HLA-DRB1 IL18
37 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.72 IL18 IL1B
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 CCL2 CCL3 IL18 IL1B TNF
39 detection of bacterium GO:0016045 9.7 HLA-DRB1 NOD2
40 positive regulation of T-helper 1 type immune response GO:0002827 9.7 IL12RB1 SLC11A1
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IFNG IL1B TNF
42 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
43 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
44 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.68 NOD2 SLC11A1
45 interleukin-6 production GO:0032635 9.67 IL18 IL1B
46 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.67 ICAM1 TNF
47 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.66 MIF TNF
48 astrocyte cell migration GO:0043615 9.66 CCL2 CCL3
49 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
50 sequestering of triglyceride GO:0030730 9.63 IL1B TNF

Molecular functions related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CCL3 IFNG IL18 IL1B LTA

Sources for Sarcoidosis 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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