SS1
MCID: SRC025
MIFTS: 61

Sarcoidosis 1 (SS1) malady

Categories: Genetic diseases, Rare diseases, Immune diseases, Neuronal diseases, Eye diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Endocrine diseases

Aliases & Classifications for Sarcoidosis 1

Aliases & Descriptions for Sarcoidosis 1:

Name: Sarcoidosis 1 54 66
Sarcoidosis 12 50 56 66 52 41 42 14 69
Boeck Sarcoid 12 56 66
Besnier-Boeck-Schaumann Disease 56 66
Sarcoidosis, Susceptibility to, 1 13
Lymphogranulomatosis 12
Schaumann's Disease 50
Sarcoid of Boeck 50
Hodgkin Disease 69
Boeck's Sarcoid 56
Ss1 66

Characteristics:

Orphanet epidemiological data:

56
sarcoidosis
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000 (Worldwide),1-5/10000 (Europe); Age of onset: Adult;

HPO:

32
sarcoidosis 1:
Inheritance sporadic


Classifications:



External Ids:

OMIM 54 181000
Disease Ontology 12 DOID:11335
ICD9CM 35 135
MeSH 42 D012507
NCIt 47 C34995
SNOMED-CT 64 154425004 31541009
Orphanet 56 ORPHA797
ICD10 via Orphanet 34 D86.0 D86.1 D86.9 more
MESH via Orphanet 43 D012507
UMLS via Orphanet 70 C0036202
UMLS 69 C0036202

Summaries for Sarcoidosis 1

NIH Rare Diseases : 50 sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. if these tiny granulomas grow and clump together in an organ, they can affect the organ's structure and function. overtime, this can lead to permanent scarring or thickening of the organ tissue (also called fibrosis). although the granulomas can be found in almost any part of the body, they occur most commonly in the lungs and lymph nodes. signs and symptoms of sarcoidosis vary based on the location of the granulomas and the severity of the condition. the exact cause of sarcoidosis is poorly understood. in many cases, treatment is not necessary and sarcoidosis will resolve on its own. however, therapies such as corticosteroids, immunosuppressants, and antimalarial drugs, are available to control symptoms, prevent complications, and improve outcomes. last updated: 4/16/2017

MalaCards based summary : Sarcoidosis 1, also known as sarcoidosis, is related to sarcoidosis 2 and angioimmunoblastic t-cell lymphoma, and has symptoms including fatigue, dyspnea and fever. An important gene associated with Sarcoidosis 1 is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dexmedetomidine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.

OMIM : 54 Sarcoidosis is a granulomatous disorder associated with an accumulation of CD4+ T cells and a Th1 immune response. In... (181000) more...

MedlinePlus : 41 sarcoidosis is a disease that leads to inflammation, usually in your lungs, skin, or lymph nodes. it starts as tiny, grain-like lumps, called granulomas. sarcoidosis can affect any organ in your body. no one is sure what causes sarcoidosis. it affects men and women of all ages and races. it occurs mostly in people ages 20 to 50, african americans, especially women, and people of northern european origin. many people have no symptoms. if you have symptoms, they may include cough shortness of breath weight loss night sweats fatigue tests to diagnose sarcoidosis include chest x-rays, lung function tests, and a biopsy. not everyone who has the disease needs treatment. if you do, prednisone, a type of steroid, is the main treatment. nih: national heart, lung, and blood institute

UniProtKB/Swiss-Prot : 66 Sarcoidosis 1: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.

Related Diseases for Sarcoidosis 1

Diseases in the Sarcoidosis, Early-Onset family:

Sarcoidosis 2 Sarcoidosis 1
Sarcoidosis 3

Diseases related to Sarcoidosis 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
id Related Disease Score Top Affiliating Genes
1 sarcoidosis 2 11.1
2 angioimmunoblastic t-cell lymphoma 11.0
3 intussusception 10.4 IL1B TNF
4 dermatosis papulosa nigra 10.4 ACE NOD2 TNF
5 distal trisomy 14q 10.4 HLA-DRB1 IFNG TNF
6 clostridium difficile colitis 10.4 HLA-DRB1 IFNG TNF
7 non-amyloid monoclonal immunoglobulin deposition disease 10.4 HLA-DRB1 IL2RA SLC11A1
8 nystagmus, congenital motor, autosomal recessive 10.4 HLA-DRB1 SLC11A1 TNF
9 psoriatic arthritis 10.4 IL18 NOD2 TNF
10 amyotrophic lateral sclerosis type 5 10.3 IL2RA NOD2 TNF
11 pancreatic signet ring cell adenocarcinoma 10.3 HLA-DRB1 IFNG TNF
12 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IFNG IL2RA TNF
13 hereditary alpha tryptasemia syndrome 10.3 HLA-DRB1 IFNG TNF
14 hepatitis 10.3 HLA-DRB1 IFNG TNF
15 human immunodeficiency virus infectious disease 10.3 HLA-DRB1 IL1B TNF
16 benign deep fibrous histiocytoma 10.3 HLA-DRB1 IFNG TNF
17 stocco dos santos syndrome 10.3 IFNG IL1B TNF
18 parametritis 10.3 IFNG IL2RA TNF
19 peripheral artery disease 10.3 ACE HLA-DRB1 TNF
20 esophagus lymphoma 10.3 IFNG SCGB1A1 TNF
21 plummer's disease 10.3 HLA-DRB1 IFNG TNF
22 tau syndrome 10.3 IL18 IL1B TNF
23 t-cell prolymphocytic leukemia 10.3 CXCR3 IL2RA TNF
24 female reproductive system disease 10.3 IL12RB1 NOD2 TNF
25 disease of mental health 10.3 HLA-DRB1 IFNG TNF
26 meier-gorlin syndrome 3 10.3 IL1B NOD2 TNF
27 ethmoid sinus cancer 10.3 IFNG IL1B SLC11A1
28 leptospirosis 10.3 IL12RB1 NOD2 TNF
29 senile reticular retinal degeneration 10.3 IFNG IL1B TNF
30 red cell phospholipid defect with hemolysis 10.3 IFNG IL18 TNF
31 urethral intrinsic sphincter deficiency 10.3 CCL2 IFNG TNF
32 ectodermal dysplasia bartalos type 10.3 IFNG IL1B TNF
33 kernicterus due to isoimmunization 10.3 HLA-DRB1 LTA TNF
34 depressed scar 10.3 HLA-DRB1 IFNG TNF
35 acquired thrombocytopenia 10.3 IL18 IL1B TNF
36 cardiac sarcoidosis 10.3 ACE TNF TNFRSF1B
37 rickettsialpox 10.3 IFNG IL1B TNF
38 hypotrichosis 4 10.3 ICAM1 IFNG TNF
39 heart conduction disease 10.3 HLA-DRB1 IFNG IL2RA TNF
40 mansonelliasis 10.3 CHIT1 IFNG TNF
41 neurotic disorder 10.3 ICAM1 IFNG TNF
42 conduct disorder 10.3 ICAM1 IFNG TNF
43 cryptococcosis 10.3 HLA-DRB1 TNF TNFRSF1B
44 cauda equina syndrome 10.3 IL18 LTA TNF
45 amyotrophic lateral sclerosis type 14 10.3 IFNG IL1B NOD2 TNF
46 parkinson disease 11 10.3 IFNG IL1B NOD2 TNF
47 malignant oculomotor nerve tumor 10.3 CCL2 CXCR3 IFNG
48 myiasis 10.3 IFNG IL2RA SLC11A1 TNF
49 eye carcinoma in situ 10.3 IFNG IL18 TNF
50 oppositional defiant disorder 10.3 ACE CCL2 TNF

Graphical network of the top 20 diseases related to Sarcoidosis 1:



Diseases related to Sarcoidosis 1

Symptoms & Phenotypes for Sarcoidosis 1

Symptoms by clinical synopsis from OMIM:

181000

Clinical features from OMIM:

181000

Human phenotypes related to Sarcoidosis 1:

56 32 (show top 50) (show all 91)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 56 32 Frequent (79-30%) HP:0012378
2 dyspnea 56 32 Frequent (79-30%) HP:0002094
3 fever 56 32 Frequent (79-30%) HP:0001945
4 hemoptysis 56 32 Very rare (<4-1%) HP:0002105
5 chest pain 56 32 Frequent (79-30%) HP:0100749
6 joint swelling 56 32 Frequent (79-30%) HP:0001386
7 hypothyroidism 56 32 Very rare (<4-1%) HP:0000821
8 hypothermia 56 32 Very rare (<4-1%) HP:0002045
9 facial palsy 56 32 Occasional (29-5%) HP:0010628
10 cataract 56 32 Occasional (29-5%) HP:0000518
11 hepatomegaly 56 32 Occasional (29-5%) HP:0002240
12 blindness 56 32 Occasional (29-5%) HP:0000618
13 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
14 portal hypertension 56 32 Occasional (29-5%) HP:0001409
15 subcutaneous nodule 56 32 Occasional (29-5%) HP:0001482
16 pulmonary fibrosis 56 32 Occasional (29-5%) HP:0002206
17 emphysema 56 32 Occasional (29-5%) HP:0002097
18 hemolytic anemia 56 32 Very rare (<4-1%) HP:0001878
19 weight loss 56 32 Frequent (79-30%) HP:0001824
20 peripheral neuropathy 56 32 Occasional (29-5%) HP:0009830
21 thrombocytopenia 56 32 Frequent (79-30%) HP:0001873
22 hyperthyroidism 56 32 Very rare (<4-1%) HP:0000836
23 hypercalciuria 56 32 Occasional (29-5%) HP:0002150
24 heart block 56 32 Occasional (29-5%) HP:0012722
25 keratoconjunctivitis sicca 56 32 Occasional (29-5%) HP:0001097
26 diabetes insipidus 56 32 Occasional (29-5%) HP:0000873
27 glaucoma 56 32 Occasional (29-5%) HP:0000501
28 nephrocalcinosis 56 32 Occasional (29-5%) HP:0000121
29 nephrolithiasis 56 32 Occasional (29-5%) HP:0000787
30 hypercalcemia 56 32 Occasional (29-5%) HP:0003072
31 alopecia 56 32 Occasional (29-5%) HP:0001596
32 cough 56 32 Frequent (79-30%) HP:0012735
33 hepatic failure 56 32 Occasional (29-5%) HP:0001399
34 abnormality of the gastrointestinal tract 56 32 Occasional (29-5%) HP:0011024
35 lymphadenopathy 56 32 Occasional (29-5%) HP:0002716
36 bone cyst 56 32 Occasional (29-5%) HP:0012062
37 abnormality of the adrenal glands 56 32 Very rare (<4-1%) HP:0000834
38 bronchiectasis 56 32 Occasional (29-5%) HP:0002110
39 uveitis 56 32 Frequent (79-30%) HP:0000554
40 eosinophilia 56 32 Very rare (<4-1%) HP:0001880
41 pneumothorax 56 32 Occasional (29-5%) HP:0002107
42 upper airway obstruction 56 32 Occasional (29-5%) HP:0002781
43 leukopenia 56 32 Frequent (79-30%) HP:0001882
44 proximal muscle weakness 56 32 Occasional (29-5%) HP:0003701
45 chylothorax 56 32 Occasional (29-5%) HP:0010310
46 tubulointerstitial nephritis 56 32 Occasional (29-5%) HP:0001970
47 erythema nodosum 56 32 Frequent (79-30%) HP:0012219
48 abnormality of the nasal mucosa 56 32 Occasional (29-5%) HP:0000433
49 dacryocystitis 56 32 Occasional (29-5%) HP:0000620
50 hyperpigmentation of the skin 56 32 Occasional (29-5%) HP:0000953

UMLS symptoms related to Sarcoidosis 1:


coughing, snoring

GenomeRNAi Phenotypes related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 NOD2 TNF TNFRSF1B ACE ICAM1 IL18
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 NOD2 TNF TNFRSF1B ACE ICAM1 IL18

MGI Mouse Phenotypes related to Sarcoidosis 1:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 TNFRSF1B ACE CXCR3 ICAM1 IFNG IL12RB1
2 homeostasis/metabolism MP:0005376 10.1 ACE CXCR3 ICAM1 IFNG IL12RB1 IL18
3 immune system MP:0005387 10.09 NOD2 SCGB1A1 SLC11A1 TNF TNFRSF1B ACE
4 digestive/alimentary MP:0005381 9.97 IFNG IL18 IL2RA NOD2 SLC11A1 TNF
5 mortality/aging MP:0010768 9.77 IL1B IL2RA LTA NOD2 SCGB1A1 SLC11A1
6 neoplasm MP:0002006 9.32 ACE CXCR3 ICAM1 IFNG IL1B MIF

Drugs & Therapeutics for Sarcoidosis 1

Drugs for Sarcoidosis 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 263)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
7
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
8
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
9
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
10
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
11
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13
Interferon beta-1a Approved, Investigational Phase 4,Phase 3 145258-61-3 6438354
14
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
15
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
16
Nicotine Approved Phase 4,Phase 1,Phase 2 54-11-5 942 89594
17
Acetylcholine Approved Phase 4 51-84-3 187
18
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
19 tannic acid Approved, Nutraceutical Phase 4,Phase 3
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-30-3 6037
21
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 1 58-05-9 54575, 6560146 143
22 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Adrenergic Agonists Phase 4,Phase 1,Phase 2
24 Adrenergic alpha-2 Receptor Agonists Phase 4
25 Adrenergic alpha-Agonists Phase 4,Phase 1,Phase 2
26 Analgesics Phase 4,Phase 2,Phase 3
27 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
28 Analgesics, Opioid Phase 4
29 Anesthetics Phase 4,Phase 2,Phase 3
30 Anesthetics, General Phase 4
31 Anesthetics, Intravenous Phase 4
32 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
33 Epinephryl borate Phase 4
34 Hypnotics and Sedatives Phase 4
35 Narcotics Phase 4
36 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Racepinephrine Phase 4
39 Adrenocorticotropic Hormone Phase 4,Phase 2,Phase 3
40 beta-endorphin Phase 4,Phase 2,Phase 3
41 Hormone Antagonists Phase 4,Phase 2,Phase 3
42 Hormones Phase 4,Phase 2,Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
44 Melanocyte-Stimulating Hormones Phase 4,Phase 2,Phase 3
45 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Antiemetics Phase 4,Phase 3
47 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Gastrointestinal Agents Phase 4,Phase 3
49 glucocorticoids Phase 4,Phase 3,Phase 2
50 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 217)
id Name Status NCT ID Phase
1 Safety Evaluation of Dexmedetomidine for EBUS-TBNA Unknown status NCT01381627 Phase 4
2 Use of Focalin for Fatigue in Sarcoidosis Completed NCT00361387 Phase 4
3 Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension Completed NCT00403650 Phase 4
4 Fractionated Versus Target-controlled Propofol Administration in Bronchoscopy Completed NCT02246023 Phase 4
5 Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies Completed NCT01658280 Phase 4
6 Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Recruiting NCT02188017 Phase 4
7 Riociguat for Sarcoidosis Associated Pulmonary Hypertension Recruiting NCT02625558 Phase 4
8 CNS Sarcoidosis and Acthar Gel Recruiting NCT02298491 Phase 4
9 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Active, not recruiting NCT01830959 Phase 4
10 Use of CXCL9 as a Biomarker of Acthar Efficacy Not yet recruiting NCT02523092 Phase 4
11 Study of Nicotine Patches in Patients With Sarcoidosis Suspended NCT00701207 Phase 4
12 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4
13 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
14 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
15 Use of Thalidomide in Chronic Uveitis Terminated NCT00314665 Phase 4
16 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4
17 Implementation Study of Treatment Optimization Recommendations on Relapsing-Remitting Multiple Sclerosis (RR MS) Subjects Withdrawn NCT00101959 Phase 4
18 ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study Unknown status NCT02155803 Phase 2, Phase 3
19 Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension Unknown status NCT00851929 Phase 2, Phase 3
20 ACTHAR Gel for Cutaneous Sarcoidosis: An Open Label Trial Unknown status NCT02348905 Phase 2, Phase 3
21 Low-dose Dexamethasone in Newly Diagnosed Pulmonary Sarcoidosis Unknown status NCT01920919 Phase 3
22 The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis Completed NCT00794274 Phase 2, Phase 3
23 Use of Armodafinil for Fatigue in Sarcoidosis Completed NCT00555347 Phase 2, Phase 3
24 Antibody Response to Influenza Vaccine in Patients With Sarcoidosis Completed NCT00828828 Phase 3
25 Efficacy and Safety of Influenza Vaccine During Sarcoidosis Completed NCT01687517 Phase 3
26 Tadalafil for Sarcoidosis Associated Pulmonary Hypertension Completed NCT01324999 Phase 2, Phase 3
27 Trial for the Diagnosis of Sarcoidosis Completed NCT00872612 Phase 3
28 SARCOTHAL. Thalidomide in Skin Sarcoidosis Completed NCT00305552 Phase 3
29 Double Blind, Randomized Trial of Bosentan for Sarcoidosis Associated Pulmonary Hypertension Completed NCT00581607 Phase 2, Phase 3
30 A Study of Infliximab in Patients With Sarcoidosis Completed NCT00073437 Phase 3
31 Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS). Completed NCT02200146 Phase 3
32 Interferon ß-1b Treatment by Cyclical Administration Completed NCT00270816 Phase 2, Phase 3
33 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3
34 Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis With Optional Extension Phase Completed NCT00340834 Phase 3
35 A Trial on Clinical Efficacy of 1% Versus 2% Lignocaine in Cough Suppression and Pain Relief in Patients Undergoing Flexible Bronchoscopy Completed NCT01955824 Phase 2, Phase 3
36 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
37 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) Completed NCT01052428 Phase 2, Phase 3
38 Study to Evaluate the Efficacy and Safety of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) in Japanese Adults With Subgenotype 1b Chronic Hepatitis C Virus (HCV) Infection Completed NCT02023099 Phase 3
39 Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis Completed NCT00906399 Phase 3
40 Effects of Linagliptin on Endothelial- , Renal-, and Retinal Function in Patients With Hypertension and Albuminuria Completed NCT02376075 Phase 3
41 Effect of the Number of Needle Revolutions Inside the Node on the Diagnostic Yield of EBUS-TBNA in Sarcoidosis Recruiting NCT02875756 Phase 2, Phase 3
42 Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Recruiting NCT02824419 Phase 2, Phase 3
43 Mycophenolate for Pulmonary Sarcoidosis Terminated NCT00262132 Phase 3
44 A Study to Evaluate 2 Doses Of Oral Administration Of Laquinimod Compared to Interferon ß-1a Administered by Injection in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Withdrawn NCT01975298 Phase 3
45 A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome Unknown status NCT02464319 Phase 2
46 Trial of Antimycobacterial Therapy in Sarcoidosis Completed NCT01074554 Phase 1, Phase 2
47 Rituximab for Pulmonary Sarcoidosis Completed NCT00855205 Phase 2
48 A Study of Adalimumab to Treat Sarcoidosis of the Skin Completed NCT00274352 Phase 2
49 Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With Sarcoidosis Completed NCT02039687 Phase 2
50 Atorvastatin to Treat Pulmonary Sarcoidosis Completed NCT00279708 Phase 2

Search NIH Clinical Center for Sarcoidosis 1

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: sarcoidosis

Genetic Tests for Sarcoidosis 1

Anatomical Context for Sarcoidosis 1

MalaCards organs/tissues related to Sarcoidosis 1:

39
Lung, Skin, Lymph Node, Eye, T Cells, Liver, Heart

Publications for Sarcoidosis 1

Articles related to Sarcoidosis 1:

id Title Authors Year
1
Sarcoidosis. 1. ( 5059500 )
1972
2
Pulmonary sarcoidosis. 1. Pathophysiologic correlations. ( 5649858 )
1968
3
Sarcoidosis. 1. Ultrastructural investigations on epithelioid cell granulomas. ( 5955900 )
1966

Variations for Sarcoidosis 1

ClinVar genetic disease variations for Sarcoidosis 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HLA-DRB1 HLA-DRB1, HLA-DRB1*1101 undetermined variant risk factor

Expression for Sarcoidosis 1

Search GEO for disease gene expression data for Sarcoidosis 1.

Pathways for Sarcoidosis 1

Pathways related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14 BTNL2 CCL2 CCL3 CHIT1 HLA-DRB1 ICAM1
2
Show member pathways
13.9 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
3
Show member pathways
13.73 CCL2 CCL3 CXCR3 IFNG IL12RB1 IL18
4
Show member pathways
13.61 CCL2 CCL3 ICAM1 IFNG IL12RB1 IL18
5
Show member pathways
13.49 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
6
Show member pathways
13.38 CCL2 CCL3 CXCR3 IL12RB1 IL18 IL1B
7
Show member pathways
13.25 CCL2 CCL3 HLA-DRB1 ICAM1 IFNG IL12RB1
8
Show member pathways
12.96 ACE CCL2 CCL3 IFNG IL1B TNF
9
Show member pathways
12.94 HLA-DRB1 ICAM1 IFNG IL1B IL2RA LTA
10
Show member pathways
12.84 CCL2 HLA-DRB1 ICAM1 IFNG IL18 IL1B
11
Show member pathways
12.73 HLA-DRB1 IFNG IL12RB1 IL18 IL2RA TNF
12
Show member pathways
12.71 IFNG IL1B LTA TNF TNFRSF1B
13
Show member pathways
12.68 CCL2 IFNG IL12RB1 IL18 IL1B TNF
14
Show member pathways
12.68 HLA-DRB1 IFNG IL12RB1 IL18 IL1B IL2RA
15 12.63 CCL2 IFNG IL1B IL2RA TNF TNFRSF1B
16 12.5 HLA-DRB1 ICAM1 IL2RA LTA TNF
17
Show member pathways
12.41 CCL2 ICAM1 IFNG IL1B TNF
18
Show member pathways
12.36 CCL2 IFNG IL1B TNF
19 12.32 HLA-DRB1 IFNG IL18 IL1B NOD2 TNF
20
Show member pathways
12.31 IFNG IL1B MIF TNF
21
Show member pathways
12.29 HLA-DRB1 IFNG IL1B TNF
22
Show member pathways
12.25 IFNG IL18 IL1B LTA TNF
23 12.2 CCL2 ICAM1 IFNG IL1B TNF
24 12.13 CCL2 ICAM1 IFNG IL1B MIF TNF
25 12.09 CCL2 ICAM1 IL18 IL1B TNF TNFRSF1B
26
Show member pathways
12.05 IFNG IL12RB1 IL18 IL1B LTA TNF
27
Show member pathways
12.03 CCL3 HLA-DRB1 IFNG IL12RB1 IL18 IL1B
28 11.99 CCL2 ICAM1 IL1B TNF
29 11.98 HLA-DRB1 IL1B IL2RA TNF
30 11.98 CCL2 ICAM1 IL1B LTA NOD2 TNF
31 11.96 ICAM1 IL1B LTA TNF
32 11.91 CCL3 IFNG IL18 IL1B
33
Show member pathways
11.84 LTA TNF TNFRSF1B
34 11.82 ICAM1 IL2RA LTA TNF
35
Show member pathways
11.79 IFNG IL2RA TNF
36 11.79 IFNG IL1B TNF
37
Show member pathways
11.78 ICAM1 IFNG IL1B MIF TNF
38 11.77 CCL2 CCL3 IL1B TNF
39 11.73 IFNG IL12RB1 IL2RA
40
Show member pathways
11.68 IFNG IL2RA TNF
41
Show member pathways
11.65 IFNG LTA TNF TNFRSF1B
42 11.65 CCL2 IFNG IL18 IL1B TNF
43 11.63 IL18 IL1B TNF
44 11.62 LTA TNF TNFRSF1B
45 11.57 IFNG IL1B TNF
46 11.54 CCL2 ICAM1 IFNG IL18 IL1B TNF
47 11.53 IFNG IL1B TNF
48
Show member pathways
11.52 CCL3 IFNG IL2RA TNF TNFRSF1B
49 11.51 CCL2 CCL3 HLA-DRB1 ICAM1 IFNG IL18
50 11.49 IL18 IL1B NOD2

GO Terms for Sarcoidosis 1

Cellular components related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ACE CCL2 CCL3 CHIT1 IFNG IL18
2 cell surface GO:0009986 9.8 CXCR3 HLA-DRB1 ICAM1 IL2RA MIF NOD2
3 extracellular space GO:0005615 9.73 ACE CCL2 CCL3 CHIT1 ICAM1 IFNG
4 lysosome GO:0005764 9.72 ACE CHIT1 HLA-DRB1 IL1B SLC11A1
5 external side of plasma membrane GO:0009897 9.23 ACE CXCR3 HLA-DRB1 ICAM1 IFNG IL12RB1

Biological processes related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.98 IFNG IL1B MIF TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 ICAM1 IL1B NOD2 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 CCL2 CCL3 ICAM1 MIF NOD2 TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.91 CCL3 IL18 TNF
5 cellular response to interleukin-1 GO:0071347 9.91 CCL2 CCL3 ICAM1
6 cellular response to lipopolysaccharide GO:0071222 9.91 CCL2 ICAM1 IFNG TNF TNFRSF1B
7 response to lipopolysaccharide GO:0032496 9.91 CCL2 ICAM1 IL1B LTA SCGB1A1 SLC11A1
8 response to glucocorticoid GO:0051384 9.9 CCL2 SCGB1A1 TNF
9 chemokine-mediated signaling pathway GO:0070098 9.9 CCL2 CCL3 CXCR3
10 interferon-gamma-mediated signaling pathway GO:0060333 9.9 HLA-DRB1 ICAM1 IFNG
11 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
12 positive regulation of JNK cascade GO:0046330 9.89 IL1B NOD2 TNF
13 neutrophil chemotaxis GO:0030593 9.89 CCL2 CCL3 IFNG IL1B
14 positive regulation of T cell proliferation GO:0042102 9.88 BTNL2 IFNG IL1B IL2RA
15 cellular response to interferon-gamma GO:0071346 9.88 CCL2 CCL3 ICAM1 IL12RB1
16 humoral immune response GO:0006959 9.87 CCL2 IFNG LTA TNF
17 positive regulation of cell adhesion GO:0045785 9.86 CCL2 IFNG TNF
18 positive regulation of interleukin-6 production GO:0032755 9.85 IL1B NOD2 TNF
19 extrinsic apoptotic signaling pathway GO:0097191 9.85 IFNG TNF TNFRSF1B
20 positive regulation of tumor necrosis factor production GO:0032760 9.85 CCL2 CCL3 IFNG NOD2
21 negative regulation of T cell proliferation GO:0042130 9.83 HLA-DRB1 IL2RA SCGB1A1
22 response to bacterium GO:0009617 9.82 CCL2 CHIT1 SLC11A1
23 positive regulation of phagocytosis GO:0050766 9.81 IL1B SLC11A1 TNF
24 positive regulation of activated T cell proliferation GO:0042104 9.81 IL12RB1 IL18 IL2RA
25 positive regulation of interleukin-8 production GO:0032757 9.8 IL1B NOD2 TNF
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 ICAM1 IFNG IL1B TNF
27 positive regulation of interleukin-1 beta secretion GO:0050718 9.79 CCL3 IFNG NOD2
28 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL18 IL1B TNF
29 protein kinase B signaling GO:0043491 9.78 CCL2 CCL3 IL1B TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.77 IFNG LTA TNF
31 macrophage chemotaxis GO:0048246 9.74 CCL2 CCL3
32 positive regulation of interleukin-17 production GO:0032740 9.74 IL18 NOD2
33 inflammatory response to antigenic stimulus GO:0002437 9.74 HLA-DRB1 IL2RA
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL1B TNF
35 T-helper 1 type immune response GO:0042088 9.73 HLA-DRB1 IL18
36 T cell chemotaxis GO:0010818 9.73 CCL3 CXCR3
37 positive regulation of T-helper 1 type immune response GO:0002827 9.73 IL12RB1 SLC11A1
38 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL18 IL1B
39 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IFNG IL1B TNF
40 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 CCL3 IL18 IL1B NOD2 TNF
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 CCL2 CCL3 IL18 IL1B TNF
42 detection of bacterium GO:0016045 9.71 HLA-DRB1 NOD2
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 IFNG IL1B
44 regulation of defense response to virus by host GO:0050691 9.71 IFNG IL1B
45 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF TNFRSF1B
46 positive regulation of cellular extravasation GO:0002693 9.7 CCL2 ICAM1
47 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.7 NOD2 SLC11A1
48 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
49 receptor-mediated virion attachment to host cell GO:0046813 9.69 ACE ICAM1
50 astrocyte cell migration GO:0043615 9.69 CCL2 CCL3

Molecular functions related to Sarcoidosis 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CCL3 IFNG IL18 IL1B LTA

Sources for Sarcoidosis 1

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