MCID: SRC014
MIFTS: 63

Sarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Sarcoma

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from embryonic mesoderm.

MalaCards: Sarcoma, also known as connective and soft tissue neoplasm, is related to synovial sarcoma and clear cell sarcoma. An important gene associated with Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Transcriptional misregulation in cancer and Endometrial cancer. The drugs thiotepa and ifosfamide and the compounds oligonucleotide and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and liver.

Wikipedia:63 A sarcoma (from the Greek σάρξ sarx meaning \"flesh\") is a cancer that arises from transformed... more...

Aliases & Classifications for Sarcoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

sarcoma 8 10 44 60
connective and soft tissue neoplasm 8
tumor of soft tissue and skeleton 8


External Ids:

Disease Ontology8 DOID:1115
SNOMED-CT56 187985009, 93765001
ICD9CM27 171, 171.9

Related Diseases for Sarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 769)
idRelated DiseaseScoreTop Affiliating Genes
1synovial sarcoma31.7FLI1, SSX2, SSX4, SS18, SSX1, SSX3
2clear cell sarcoma31.4BRAF, EWSR1, KIT
3leukemia31.0JUN, FES, EWSR1, FLI1, KIT
4melanoma31.0JUN, BRAF, EWSR1, FLI1, SSX2, SSX4
5peripheral primitive neuroectodermal tumor30.9EWSR1, FLI1, SS18, KIT
6acute leukemia30.9EWSR1, KIT
7rhabdomyosarcoma30.9FLI1, EWSR1
8myeloid leukemia30.8KIT, FES, JUN
9liposarcoma30.5FLI1, EWSR1
10fibrosarcoma30.3JUN
11kidney hemangiopericytoma29.5SS18, SSX2
12kaposi's sarcoma11.2
13epithelioid sarcoma11.0
14endometrial stromal sarcoma11.0
15alveolar soft part sarcoma11.0
16myeloid sarcoma10.9
17dendritic cell sarcoma10.8
18retroperitoneal sarcoma10.8
19kidney sarcoma10.8
20spindle cell sarcoma10.8
21liver sarcoma10.8
22follicular dendritic cell sarcoma10.8
23primitive neuroectodermal tumor10.7
24kidney clear cell sarcoma10.7
25breast sarcoma10.7
26monophasic synovial sarcoma10.6
27lung sarcoma10.6
28interdigitating dendritic cell sarcoma10.5
29small cell sarcoma10.5
30langerhans cell sarcoma10.5
31biphasic synovial sarcoma10.5
32brain sarcoma10.5
33osteosarcoma10.5
34acute myeloid leukemia10.5
35extraosseous ewing's sarcoma10.5
36mast-cell sarcoma10.5
37bone ewing's sarcoma10.5
38histiocytoma10.4
39fibrous histiocytoma10.4
40skin sarcoma10.4
41acquired immunodeficiency syndrome10.4
42prostate sarcoma10.4
43colon sarcoma10.4
44mediastinitis10.4
45endometriosis10.4
46hepatitis10.4
47bladder sarcoma10.4
48heart sarcoma10.4
49leiomyosarcoma10.4
50localized ewing's sarcoma10.4

Graphical network of the top 20 diseases related to Sarcoma:



Diseases related to sarcoma

Clinical Features for Sarcoma

About this section

Drugs & Therapeutics for Sarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sarcoma

Drug clinical trials:

Search ClinicalTrials for Sarcoma

Search NIH Clinical Center for Sarcoma

Search CenterWatch for Sarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sarcoma

About this section

Anatomical Context for Sarcoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Sarcoma:

32
Myeloid, Bone, Liver, Kidney, Breast, Endothelial, Lung, Colon, Lymph node, Uterus, Brain, Tongue, Bone marrow, Skin, Prostate, T cells, Cervix, B cells, Heart, Smooth muscle, Thyroid, Ovary, Monocytes, Spleen, Small intestine, Tonsil, Skeletal muscle, Testes, Spinal cord, Adrenal gland, Pituitary, Testis, Pancreas, Appendix, Placenta, Nk cells, Pineal, Eye, B lymphoblasts, Salivary gland, Trachea, Cerebellum, Pancreatic islet, Retina, Thymus

Animal Models for Sarcoma or affiliated genes

About this section

Publications for Sarcoma

About this section
Sources:
50PubMed
See all sources

Articles related to Sarcoma:

(show top 50)    (show all 7367)
idTitleAuthorsYear
1
Endobronchial ultrasound-guided transbronchial needle aspiration of an intravascular sarcoma metastasis. (24081000)
2013
2
Huge undifferentiated fibroblastic sarcoma of the foot and lower leg: impact of diagnostic delay and discussion of an entity. (24121812)
2013
3
Primary intimal (spindle cell) sarcoma of the heart: a case report and review of the literature. (23424592)
2013
4
Pazopanib, a new therapy for metastatic soft tissue sarcoma. (23488774)
2013
5
Non-puerperal uterine inversion caused by malignant mixed mullerian sarcoma. (24334469)
2013
6
Neutrality of miniSTR D22S1045 marker by Ewing's sarcoma phenotype. (24112992)
2013
7
Primary granulocytic sarcoma of meninges and mediastinum as diagnostic dilemma. (24426349)
2013
8
Proximal-type epithelioid sarcoma -- case report. (23793215)
2013
9
A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma. (22698405)
2012
10
Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi's Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. (23420076)
2012
11
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. (22498828)
2012
12
Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs. (22235831)
2012
13
A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo. (23185331)
2012
14
Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients. (22748119)
2012
15
Surgical technique, morbidity, and outcome of primary retroperitoneal sarcoma involving inferior vena cava. (21792507)
2012
16
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
17
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. (21625290)
2011
18
Biphasic synovial sarcoma in mandibular region. (22529590)
2011
19
Kaposi's sarcoma-associated herpesvirus load in asymptomatic contacts of Cuban epidemic KS patients. (20852904)
2010
20
The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice. (20472805)
2010
21
Primary synovial sarcoma arising from a crossed ectopic kidney with fusion. (20377831)
2010
22
Trends in Kaposi's sarcoma survival disparities in the United States: 1980 through 2004. (20861396)
2010
23
ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. (20197394)
2010
24
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. (19107931)
2009
25
Rare tumor of the tongue in a child: alveolar soft part sarcoma. (18630993)
2009
26
Low-grade endometrial stromal sarcoma with inferior vena cava tumor thrombus and intracardiac extension: radical resection may improve recurrence free survival. (18708288)
2009
27
Epithelioid sarcoma-like haemangioendothelioma: a case report. (19326021)
2009
28
Treatment and outcomes of patients with primary breast sarcoma. (18723152)
2008
29
The complex cytological features of synovial sarcoma in fine needle aspirates, an analysis of four illustrative cases. (17559565)
2007
30
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation. (17513613)
2007
31
Nail-patella syndrome associated with Ewing sarcoma. (17696103)
2007
32
Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. (17597077)
2007
33
The effects of the CDK inhibitor seliciclib alone or in combination with cisplatin in human uterine sarcoma cell lines. (17300833)
2007
34
Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma. (17895898)
2007
35
Loss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas. (16082560)
2005
36
HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (15902698)
2005
37
N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6. (14970177)
2004
38
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. (12569572)
2003
39
Cytologic features of alveolar soft part sarcoma: report of three cases. (12203880)
2002
40
Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts). (11207050)
2001
41
Clear cell sarcoma of the kidney: a review of 351 cases from the National Wilms Tumor Study Group Pathology Center. (10632483)
2000
42
Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. (10231412)
1999
43
Alveolar soft part sarcoma in children and adolescents: clinical features and outcome of 11 patients. (8531857)
1996
44
Clear cell sarcoma mimicking peripheral nerve sheath tumor. (8848756)
1996
45
Inhibition of HSP47 during the transition from solid to ascitic form of Sarcoma 180 in vivo. (8900931)
1995
46
Neonatal colorectal spindle cell sarcoma. (1765926)
1991
47
Primary spinal epidural extraosseous Ewing's sarcoma. (2065287)
1991
48
Epithelioid sarcoma. (4094985)
1985
49
Sarcomas--a clinicopathological guide with special reference to cutaneous manifestation. IV. Extraskeletal osteosarcoma, extraskeletal chondrosarcoma, alveolar soft part sarcoma, clear cell sarcoma and discussion. (3912082)
1985
50
Multiple genital neoplasia (mast cell sarcoma, seminoma, and sertoli cell tumor) in a dog. (13306668)
1956

Genetic Variations for Sarcoma

About this section

Expression for genes affiliated with Sarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sarcoma

Search GEO for disease gene expression data for Sarcoma.

Pathways for genes affiliated with Sarcoma

About this section
Sources:
29KEGG, 12EMD Millipore, 49PharmGKB, 59Tocris Bioscience, 37NCBI BioSystems Database
See all sources

Pathways related to Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9ASPSCR1, SSX1, SS18, SSX2B, SSX2, FLI1
2
Hide members
11.1KIT, BRAF, JUN
3
Hide members
11.1JUN, BRAF, KIT
410.9BRAF, JUN

Compounds for genes affiliated with Sarcoma

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligonucleotide4411.8PATZ1, JUN, BRAF, EWSR1, FLI1, SSX2
2Regorafenib1110.9KIT, BRAF
3geldanamycin44 49 59 1113.8KIT, BRAF, JUN

GO Terms for genes affiliated with Sarcoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.6ASPSCR1, EWSR1, FLI1, SSX6, SSX7, SSX2B

Biological processes related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.9PATZ1, EWSR1, FLI1, SSX6, SSX7, SSX2B
2regulation of transcription, DNA-dependentGO:00635512.4SSX2B, SSX7, SSX6, EWSR1, SSX4B, SSX5
3response to radiationGO:00931410.9KIT, JUN
4megakaryocyte developmentGO:03585510.8FLI1, KIT
5regulation of cell motilityGO:200014510.6SSX2IP, FES

Molecular functions related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367611.8SSX9, SSX6, SSX7, SSX2B, SSX4B, SSX5
2RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.9FLI1, JUN

Products for genes affiliated with Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet