MCID: SRC014
MIFTS: 70

Sarcoma malady

Cancer diseases, Bone diseases categories
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Summaries for Sarcoma

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Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from embryonic mesoderm.

MalaCards based summary: Sarcoma, also known as connective and soft tissue neoplasm, is related to clear cell sarcoma and synovial sarcoma. An important gene associated with Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Signaling events mediated by focal adhesion kinase and Renal cell carcinoma. The drugs ifosfamide and mitoxantrone and the compounds ag-1296 and perillyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and liver, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:65 A sarcoma (from the Greek ???? sarx meaning \"flesh\") is a cancer that arises from transformed cells of... more...

Aliases & Classifications for Sarcoma

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Sarcoma, Aliases & Descriptions:

Name: Sarcoma 8 10 44 62
Connective and Soft Tissue Neoplasm 8
 
Tumor of Soft Tissue and Skeleton 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:1115
SNOMED-CT57 187985009, 93765001
ICD9CM27 171, 171.9

Related Diseases for Sarcoma

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Diseases related to Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 823)
idRelated DiseaseScoreTop Affiliating Genes
1clear cell sarcoma32.3BRAF, KIT, EWSR1
2synovial sarcoma32.2FLI1, SSX1, SS18, SSX2, KIT, SSX4
3neuroectodermal tumor31.9FLI1, EWSR1
4peripheral primitive neuroectodermal tumor31.7EWSR1, FLI1
5liposarcoma31.4EWSR1, FLI1
6leukemia31.4FGF4, EWSR1, FES, JUN, FLI1, SRC
7myeloid leukemia31.3FES, JUN, SRC, HRAS, KIT
8melanoma31.1BRAF, FLI1, HRAS, KIT, SSX2, SSX1
9breast cancer31.1SRC, HRAS, FGF4
10hemangioma30.9FES, FLI1, FGF4
11glioblastoma30.7KIT, SRC, HRAS, JUN
12seminoma30.7BRAF, SSX2, KIT, FGF4
13ovarian cancer30.5BRAF, JUN, SRC, SSX2, HRAS
14chronic myeloid leukemia30.5FES, HRAS, KIT, SRC
15lung adenocarcinoma30.5HRAS, BRAF, JUN, SRC
16adenoma30.4FGF4, HRAS, BRAF, SRC
17spitz nevus30.3BRAF, HRAS
18endometrial carcinoma30.1BRAF, FGF4, HRAS, JUN
19prostate cancer29.8JUN, PATZ1, FLI1, SRC, FGF4
20kaposi's sarcoma11.3
21soft tissue sarcoma11.2
22endometrial stromal sarcoma11.0
23epithelioid sarcoma11.0
24alveolar soft part sarcoma11.0
25myeloid sarcoma10.9
26uterine sarcoma10.9
27dendritic cell sarcoma10.9
28histiocytic sarcoma10.9
29follicular dendritic cell sarcoma10.8
30retroperitoneal sarcoma10.8
31embryonal sarcoma10.8
32spindle cell sarcoma10.8
33endotheliitis10.7
34undifferentiated embryonal sarcoma of the liver10.7
35rhabdomyosarcoma10.7
36classic kaposi sarcoma10.7
37monophasic synovial sarcoma10.6
38primary effusion lymphoma10.6
39interdigitating dendritic cell sarcoma10.6
40osteosarcoma10.6
41biphasic synovial sarcoma10.6
42langerhans cell sarcoma10.6
43extraosseous ewing's sarcoma10.6
44cardiofaciocutaneous syndrome10.5BRAF
45kidney hemangiopericytoma10.5SS18, SSX2
46connective tissue benign neoplasm10.5FLI1, EWSR1
47acute myeloid leukemia10.5
48breast sarcoma10.5
49castleman's disease10.5
50mast-cell sarcoma10.5

Graphical network of the top 20 diseases related to Sarcoma:



Diseases related to sarcoma

Symptoms for Sarcoma

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Drugs & Therapeutics for Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Sarcoma

Search NIH Clinical Center for Sarcoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Sarcoma

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Anatomical Context for Sarcoma

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MalaCards organs/tissues related to Sarcoma:

32
Myeloid, Bone, Liver, Kidney, Breast, Endothelial, Lung, Colon, Lymph node, Uterus, Brain, Tongue, Bone marrow, Skin, Prostate, Cervix, T cells, B cells, Heart, Thyroid, Smooth muscle, Monocytes, Spleen, Small intestine, Ovary, Tonsil, Neutrophil, Skeletal muscle, Testes, Spinal cord, Adrenal gland, Pituitary, Testis, Pancreas, Placenta, Appendix, Eye, Salivary gland, Nk cells, B lymphoblasts, Pineal, Thymus, Cerebellum, Retina, Trachea, Pancreatic islet

Animal Models for Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Sarcoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9HRAS, EWSR1, FES, BRAF, FLI1, SRC
2MP:00107719.8EWSR1, FES, BRAF, JUN, SRC, KIT
3MP:00053909.8EWSR1, BRAF, JUN, SRC, KIT, HRAS
4MP:00053799.8BRAF, JUN, PATZ1, KIT, HRAS, EWSR1
5MP:00053809.7BRAF, JUN, FLI1, PATZ1, SRC, SS18
6MP:00053859.7FES, BRAF, JUN, FLI1, PATZ1, SS18
7MP:00028739.7EWSR1, FES, BRAF, JUN, KIT, HRAS
8MP:00053889.6BRAF, JUN, SRC, KIT, HRAS, FGF4
9MP:00036319.5FES, BRAF, JUN, FLI1, PATZ1, SRC
10MP:00053979.5EWSR1, FES, BRAF, JUN, FLI1, PATZ1
11MP:00053789.5JUN, BRAF, FES, EWSR1, FLI1, PATZ1
12MP:00107689.3EWSR1, FES, BRAF, JUN, FLI1, PATZ1
13MP:00053879.2EWSR1, FES, BRAF, JUN, FLI1, PATZ1

Publications for Sarcoma

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Articles related to Sarcoma:

(show top 50)    (show all 7625)
idTitleAuthorsYear
1
De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. (23095217)
2013
2
Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. (24374597)
2013
3
Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein. (24130893)
2013
4
SS18-SSX fusion protein-induced Wnt/I^-catenin signaling is a therapeutic target in synovial sarcoma. (24166495)
2013
5
Monitoring the adequacy of surgical margins after resection of bone and soft-tissue sarcoma. (23370669)
2013
6
Pulmonary artery sarcoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. (23910141)
2013
7
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
8
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
9
Images in vascular medicine. Spindle cell sarcoma of the common femoral vein as a possible differential for deep venous thrombosis on ultrasound. (22951535)
2013
10
Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. (22398019)
2012
11
Primitive neuroectodermal tumor/Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis. (21063743)
2011
12
High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis. (20730890)
2011
13
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy. (21277011)
2011
14
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins. (20484563)
2010
15
Clinicopathologic features of granulocytic sarcoma: a study of 38 cases]. (20450763)
2010
16
PML down-regulation in soft tissue sarcomas. (20578240)
2010
17
Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report. (22966400)
2010
18
INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics. (19318800)
2009
19
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. (19107931)
2009
20
Staging of soft tissue sarcoma: what is new? (18685895)
2008
21
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
22
Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). (18760530)
2008
23
Low-grade endometrial stromal sarcoma: a single center's experience with 22 cases. (18179547)
2008
24
Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas. (17175375)
2007
25
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. (16782856)
2006
26
Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. (16501115)
2006
27
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. (16585191)
2006
28
Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line. (16705698)
2006
29
Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas. (16930603)
2006
30
p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. (15652749)
2005
31
Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. (15893992)
2005
32
Loss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas. (16082560)
2005
33
Imatinib mesylate (gleevec)--targeted kinases are expressed in uterine sarcomas. (15894930)
2005
34
Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by alpha-DL-tocopherol. (15451550)
2004
35
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. (15355900)
2004
36
Low-grade sarcomas with CD34-positive fibroblasts and low-grade myofibroblastic sarcomas. (15764578)
2004
37
Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. (12747473)
2003
38
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. (12801270)
2003
39
APC mutations in synovial sarcoma. (11920741)
2002
40
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
41
Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. (9739024)
1998
42
A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). (9309124)
1997
43
The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (8840996)
1996
44
Dramatic response to ifosfamide, mesna and doxorubicin chemotherapy regimen in an adult with clear cell sarcoma of the kidney. (8618315)
1996
45
Inhibition of RNA splicing at the Rous sarcoma virus src 3' splice site is mediated by an interaction between a negative cis element and a chicken embryo fibroblast nuclear factor. (7609076)
1995
46
Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. (8133539)
1994
47
The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members. (8502483)
1993
48
Uterine malignancy developing after long term use of IUCD additional report of 2 cases: endometrial stromal sarcoma and leiomyosarcoma. (2597086)
1989
49
Epithelioid sarcoma of penis. (3750610)
1986
50
Alveolar soft-part sarcoma. Report of a case presenting as a sacral bone tumor. (5762710)
1969

Variations for Sarcoma

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Expression for genes affiliated with Sarcoma

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Expression patterns in normal tissues for genes affiliated with Sarcoma

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Pathways for genes affiliated with Sarcoma

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Pathways related to Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1JUN, SRC, BRAF
210.1JUN, BRAF, HRAS
3
Show member pathways
10.1HRAS, BRAF, JUN
410.1JUN, SRC, HRAS
510.1HRAS, SRC, JUN
610.1JUN, SRC, HRAS
7
Show member pathways
Development Flt3 signaling60
10.1JUN, HRAS, SRC
810.1JUN, HRAS, SRC
9
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
10.1SRC, HRAS, JUN
1010.1HRAS, JUN, SRC
11
Show member pathways
Development Activation of ERK by Alpha 1 adrenergic receptors60
10.1SRC, JUN, HRAS
1210.1SRC, JUN, HRAS
13
Show member pathways
10.1SRC, BRAF, HRAS
14
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
10.1SRC, FES, HRAS
15
Show member pathways
VEGFR1 specific signals37
10.1FES, HRAS, SRC
16
Show member pathways
10.0BRAF, JUN, KIT, HRAS
17
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.0BRAF, JUN, SRC, HRAS
18
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.0BRAF, JUN, SRC, HRAS
19
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
10.0JUN, SRC, BRAF, HRAS
20
Show member pathways
10.0BRAF, JUN, SRC, HRAS
21
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
10.0JUN, BRAF, SRC, HRAS
22
Show member pathways
RAC1 signaling pathway37
10.0BRAF, JUN, SRC, HRAS
23
Show member pathways
10.0JUN, BRAF, SRC, HRAS
2410.0HRAS, SRC, JUN, BRAF
25
Show member pathways
10.0BRAF, HRAS, SRC, JUN
26
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
10.0HRAS, SRC, BRAF, JUN
2710.0HRAS, JUN, BRAF, SRC
28
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
10.0HRAS, BRAF, JUN, SRC
29
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
10.0HRAS, KIT, SRC, FES
30
Show member pathways
9.9SRC, BRAF, HRAS, FGF4
31
Show member pathways
9.9HRAS, FGF4, SRC, BRAF
32
Show member pathways
Signaling Pathways in Glioblastoma37
9.9BRAF, HRAS, FGF4, SRC
339.9FGF4, BRAF, HRAS, SRC
34
Show member pathways
Signal transduction PTEN pathway60
9.9BRAF, JUN, SRC, KIT, HRAS
35
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.9KIT, SRC, JUN, BRAF, HRAS
369.8FGF4, HRAS, KIT, JUN, BRAF
37
Show member pathways
9.8FGF4, KIT, JUN, BRAF, HRAS
38
Show member pathways
9.8KIT, BRAF, SRC, FGF4, HRAS
39
Show member pathways
9.8SRC, BRAF, KIT, FGF4, HRAS
40
Show member pathways
9.8KIT, BRAF, HRAS, FGF4, SRC
41
Show member pathways
9.8BRAF, FGF4, HRAS, KIT, SRC
42
Show member pathways
9.7BRAF, JUN, SRC, HRAS, FGF4, KIT
43
Show member pathways
9.7BRAF, JUN, SRC, KIT, HRAS, FGF4
44
Show member pathways
9.7BRAF, FGF4, JUN, KIT, HRAS, SRC
45
Show member pathways
9.7FGF4, SRC, HRAS, KIT, BRAF, JUN
46
Show member pathways
9.7FES, JUN, SRC, KIT, HRAS, FGF4
47
Show member pathways
9.7FGF4, HRAS, JUN, BRAF, FES, SRC
48
Show member pathways
9.7FGF4, KIT, SSX2IP, SRC, JUN, HRAS
499.6FGF4, KIT, FAU, BRAF, SRC, HRAS
509.6SSX1, EWSR1, FLI1, SSX2, SS18, SSX2B

Compounds for genes affiliated with Sarcoma

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Compounds related to Sarcoma according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1ag-12964410.5KIT, SRC
2perillyl alcohol44 2411.5HRAS, JUN
3helenalin4410.5SRC, JUN
4pertussis4410.5JUN, SRC, HRAS
5ebselen4410.5SRC, JUN
6gp 1304410.5HRAS, KIT, SRC
7geldanamycin44 50 61 1113.4BRAF, JUN, SRC, KIT
8ponatinib50 1111.4KIT, SRC
9gf 109203x44 6111.4JUN, SRC, HRAS
10phenylalanine4410.4HRAS, KIT, SRC, BRAF
11paclitaxel44 50 1112.4BRAF, SRC, KIT, HRAS
12phosphotyrosine4410.3HRAS, KIT, SRC, FES
13ly2940024410.3BRAF, JUN, SRC, HRAS
14herbimycin a44 6111.3JUN, SRC, HRAS
15wortmannin4410.3BRAF, JUN, SRC, HRAS
16staurosporin4410.3SRC, JUN
17rapamycin4410.3BRAF, JUN, SRC, KIT, HRAS
18paraffin4410.3HRAS, KIT, BRAF, EWSR1
19pd 98,0594410.3BRAF, JUN, SRC, KIT, HRAS
20phosphoinositide4410.3BRAF, JUN, SRC, KIT, HRAS
21imatinib44 50 1112.3BRAF, SRC, KIT
22matrigel4410.3BRAF, JUN, SRC, FGF4
23regorafenib50 1111.3KIT, BRAF
24glutamine4410.2EWSR1, SS18, KIT, HRAS
25phosphatidylinositol4410.1FES, BRAF, JUN, SRC, KIT, HRAS
26threonine4410.1FES, BRAF, JUN, SRC, KIT, HRAS
27manumycin4410.1HRAS, SRC
28aspartate4410.1HRAS, KIT, SRC, BRAF
29agar4410.1FES, BRAF, JUN, SRC, HRAS, FGF4
30vegf4410.1BRAF, JUN, SRC, KIT, HRAS, FGF4
31estrogen4410.1BRAF, JUN, SRC, KIT, HRAS, FGF4
32arsenite44 2411.1JUN, FAU, SRC
33retinoic acid44 2411.0EWSR1, FES, BRAF, JUN, KIT, HRAS
34oligonucleotide449.9HRAS, EWSR1, BRAF, JUN, FLI1, PATZ1
35serine449.9EWSR1, FES, BRAF, JUN, FLI1, SRC
36valine449.8HRAS, KIT, BRAF
37tyrosine449.7EWSR1, FES, BRAF, JUN, SRC, SS18

GO Terms for genes affiliated with Sarcoma

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Cellular components related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.4BRAF, JUN, FAU, ASPSCR1, SRC, HRAS
2nucleusGO:0056348.2FGF4, EWSR1, BRAF, FLI1, PATZ1, ASPSCR1

Biological processes related to Sarcoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:01810810.3KIT, SRC, FES
2positive regulation of actin cytoskeleton reorganizationGO:200025110.3HRAS, FES
3organ morphogenesisGO:00988710.2BRAF, FLI1, HRAS
4T cell differentiationGO:03021710.2KIT, PATZ1
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.2BRAF, SRC, HRAS, FGF4
6Fc-epsilon receptor signaling pathwayGO:03809510.2JUN, KIT, HRAS, FGF4
7epidermal growth factor receptor signaling pathwayGO:00717310.2FGF4, HRAS, KIT, SRC
8regulation of cell motilityGO:200014510.2SSX2IP, FES
9fibroblast growth factor receptor signaling pathwayGO:00854310.1FGF4, HRAS, KIT, SRC, BRAF
10neurotrophin TRK receptor signaling pathwayGO:04801110.1FGF4, HRAS, KIT, SRC, BRAF
11innate immune responseGO:04508710.0JUN, SRC, KIT, HRAS, FGF4
12negative regulation of neuron apoptotic processGO:04352410.0BRAF, JUN, HRAS
13protein autophosphorylationGO:0467779.8KIT, SRC, FES
14regulation of transcription, DNA-templatedGO:0063559.7EWSR1, PATZ1, SSX1, SSX4B, SSX6, SSX2B
15transcription, DNA-templatedGO:0063519.7EWSR1, PATZ1, SSX1, SSX4B, SSX6, SSX2B

Molecular functions related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.8FES, SRC, KIT
2nucleic acid bindingGO:0036769.8SSX2B, SSX6, SSX4B, SSX1
3protein bindingGO:0055159.1FES, BRAF, JUN, ASPSCR1, SRC, SSX2IP

Products for genes affiliated with Sarcoma

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Sources for Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet