MCID: SRC014
MIFTS: 63

Sarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from embryonic mesoderm.

MalaCards: Sarcoma, also known as connective and soft tissue neoplasm, is related to synovial sarcoma and clear cell sarcoma. An important gene associated with Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Transcriptional misregulation in cancer and Endometrial cancer. The drugs thiotepa and ifosfamide and the compounds oligonucleotide and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and liver.

Wikipedia:63 A sarcoma (from the Greek σάρξ sarx meaning \"flesh\") is a cancer that arises from transformed... more...

Aliases & Classifications for Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

sarcoma 8 10 44 60
connective and soft tissue neoplasm 8
tumor of soft tissue and skeleton 8


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Disease Ontology8 DOID:1115
SNOMED-CT56 187985009, 93765001
ICD9CM27 171, 171.9

Related Diseases for Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 769)
idRelated DiseaseScoreTop Affiliating Genes
1synovial sarcoma31.7FLI1, SSX2, SSX4, SS18, SSX1, SSX3
2clear cell sarcoma31.4BRAF, EWSR1, KIT
3leukemia31.0JUN, FES, EWSR1, FLI1, KIT
4melanoma31.0JUN, BRAF, EWSR1, FLI1, SSX2, SSX4
5peripheral primitive neuroectodermal tumor30.9EWSR1, FLI1, SS18, KIT
6acute leukemia30.9EWSR1, KIT
7rhabdomyosarcoma30.9FLI1, EWSR1
8myeloid leukemia30.8KIT, FES, JUN
9liposarcoma30.5FLI1, EWSR1
10fibrosarcoma30.3JUN
11kidney hemangiopericytoma29.5SS18, SSX2
12kaposi's sarcoma11.2
13epithelioid sarcoma11.0
14endometrial stromal sarcoma11.0
15alveolar soft part sarcoma11.0
16myeloid sarcoma10.9
17dendritic cell sarcoma10.8
18retroperitoneal sarcoma10.8
19kidney sarcoma10.8
20spindle cell sarcoma10.8
21liver sarcoma10.8
22follicular dendritic cell sarcoma10.8
23primitive neuroectodermal tumor10.7
24kidney clear cell sarcoma10.7
25breast sarcoma10.7
26monophasic synovial sarcoma10.6
27lung sarcoma10.6
28interdigitating dendritic cell sarcoma10.5
29small cell sarcoma10.5
30langerhans cell sarcoma10.5
31biphasic synovial sarcoma10.5
32brain sarcoma10.5
33osteosarcoma10.5
34acute myeloid leukemia10.5
35extraosseous ewing's sarcoma10.5
36mast-cell sarcoma10.5
37bone ewing's sarcoma10.5
38histiocytoma10.4
39fibrous histiocytoma10.4
40skin sarcoma10.4
41acquired immunodeficiency syndrome10.4
42prostate sarcoma10.4
43colon sarcoma10.4
44mediastinitis10.4
45endometriosis10.4
46hepatitis10.4
47bladder sarcoma10.4
48heart sarcoma10.4
49leiomyosarcoma10.4
50localized ewing's sarcoma10.4

Graphical network of the top 20 diseases related to Sarcoma:



Diseases related to sarcoma

Clinical Features for Sarcoma

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Drugs & Therapeutics for Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sarcoma

Drug clinical trials:

Search ClinicalTrials for Sarcoma

Search NIH Clinical Center for Sarcoma

Search CenterWatch for Sarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sarcoma

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Anatomical Context for Sarcoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sarcoma:

32
Myeloid, Bone, Liver, Kidney, Breast, Endothelial, Lung, Colon, Lymph node, Uterus, Brain, Tongue, Bone marrow, Skin, Prostate, T cells, Cervix, B cells, Heart, Smooth muscle, Thyroid, Ovary, Monocytes, Spleen, Small intestine, Tonsil, Skeletal muscle, Testes, Spinal cord, Adrenal gland, Pituitary, Testis, Pancreas, Appendix, Placenta, Nk cells, Pineal, Eye, B lymphoblasts, Salivary gland, Trachea, Cerebellum, Pancreatic islet, Retina, Thymus

Animal Models for Sarcoma or affiliated genes

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Publications for Sarcoma

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Sources:
50PubMed
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Articles related to Sarcoma:

(show top 50)    (show all 7367)
idTitleAuthorsYear
1
Outcome of Ewing sarcoma in a multidisciplinary setting in Lebanon. (24395458)
2014
2
A phase I study of the combination of temsirolimus with irinotecan for metastatic sarcoma. (24216984)
2013
3
Synovial sarcoma of the larynx treated by supraglottic laryngectomy: case report and literature review. (23904312)
2013
4
miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor. (23497288)
2013
5
Complications following reconstruction of soft-tissue sarcoma: importance of early participation of the plastic surgeon. (21629048)
2012
6
Clear cell sarcoma expressing a novel chimerical transcript EWSR1 exon 7/ATF1 exon 6. (22886438)
2012
7
Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites. (22371709)
2012
8
Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. (22747712)
2012
9
Proximal Subungual Onychomycosis in a Patient with Classic Kaposi Sarcoma Caused by Trichophyton rubrum. (22028554)
2011
10
Cervical follicular dendritic cell sarcoma: a case report and review of the literature. (21658332)
2011
11
Outcomes after right-side heart sarcoma resection. (21352995)
2011
12
Incidence of lymph node and adnexal metastasis in endometrial stromal sarcoma. (21276609)
2011
13
Poorly differentiated monophasic synovial sarcoma of the mediastinum. (21623099)
2011
14
Successful treatment of a large soft tissue sarcoma with irreversible electroporation. (21321291)
2011
15
Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient. (21775763)
2011
16
Concurrent occurrence of nodular lymphocyte predominant Hodgkin lymphoma and Kaposi sarcoma in lymph nodes: a first case report. (20595178)
2010
17
Convergence of Kaposi's sarcoma-associated herpesvirus reactivation with Epstein-Barr virus latency and cellular growth mediated by the notch signaling pathway in coinfected cells. (20686042)
2010
18
The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus. (22331985)
2010
19
Diagnostic confusion resulting from CD56 expression by cutaneous myeloid sarcoma. (21139930)
2009
20
Sentinel node biopsy in synovial sarcoma. (17870276)
2008
21
Recurrent bilateral pneumothoraces associated with metastatic synovial sarcoma. (18494096)
2008
22
Follicular dendritic cell sarcoma of inguinal lymph node--a case report. (19291921)
2008
23
Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma. (19197386)
2008
24
In vitro antiproliferative and antimigratory activity of dasatinib in neuroblastoma and Ewing sarcoma cell lines. (18202781)
2008
25
Myeloid sarcoma presenting with bilateral proptosis and kidney infiltration. (17454781)
2007
26
Leydig cell tumor after treatment for Ewing's sarcoma. (16526050)
2007
27
Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. (17543078)
2007
28
Synovial sarcoma of the tendon and tendon sheath in a dog. (17019070)
2006
29
Low-grade endometrial stromal sarcoma with sex cord-like differentiation metastatic to the thoracic spines. (16948819)
2006
30
Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. (16410131)
2006
31
Epithelioid sarcoma with SYT-SSX1 fusion gene expression: molecular and cytogenetic analysis. (16157200)
2005
32
Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but not in a mt-p53 sarcoma cell line. (15583820)
2005
33
Primary gastric histiocytic sarcoma in a dog--a case report. (15533119)
2004
34
Multidrug resistance proteins in primary and metastatic soft-tissue sarcomas: down-regulation of P-glycoprotein during metastatic progression. (15015610)
2004
35
NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing sarcoma cells. (15581626)
2004
36
Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation. (15481450)
2004
37
Correspondence re: Bryant-Greenwood P, Sorbara L, Filie AC, Little R, Yarchoan R, Wilson W, Raffeld M, Abati A. Infection of mesothelial cells with human herpes virus 8 in human immunodeficiency virus-infected patients with Kaposi's sarcoma, Castleman's disease, and recurrent pleural effusions. Mod pathol 2003;16:145-53. (14681331)
2003
38
Endometrial stromal sarcoma presenting as postpartum haemorrhage: report of a case with a sole t(10;17)(q22;p13) translocation. (14529693)
2003
39
Novel fluorescent ligase detection reaction and flow cytometric analysis of SYT-SSX fusions in synovial sarcoma. (12707378)
2003
40
Stimulation of Kaposi's sarcoma cell growth by urine from women in early pregnancy, the current source for clinical-grade human chorionic gonadotropin preparations. (12190946)
2002
41
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. (11289134)
2001
42
Radiosensitization in sarcoma cell lines with a p53 missense mutation correlates with prevention of irradiation G2/M arrest but not with induction of apoptosis. (11496306)
2001
43
Inhibition of proliferation and induction of apoptosis in soft tissue sarcoma cells by interferon-alpha and retinoids. (10424735)
1999
44
Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma. (9800111)
1998
45
Carcinoma of the tongue in a long-term survivor of clear cell sarcoma of the kidney. (8597820)
1995
46
Relationship of serum levels of oncostatin M to AIDS-related and classic Kaposi's sarcoma. (7907664)
1994
47
Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. (1755102)
1991
48
Clear cell sarcoma of tendons and aponeuroses: histogenesis and mode of treatment. (2738290)
1989
49
Histiocytic sarcoma in Wistar rats. A light microscopic, immunohistochemical, and ultrastructural study. (6383258)
1984
50
Alveolar soft part sarcoma of the head and neck. (459663)
1979

Genetic Variations for Sarcoma

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Expression for genes affiliated with Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sarcoma

Search GEO for disease gene expression data for Sarcoma.

Pathways for genes affiliated with Sarcoma

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29KEGG, 12EMD Millipore, 49PharmGKB, 59Tocris Bioscience, 37NCBI BioSystems Database
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Pathways related to Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9ASPSCR1, SSX1, SS18, SSX2B, SSX2, FLI1
2
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11.1KIT, BRAF, JUN
3
Hide members
11.1JUN, BRAF, KIT
410.9BRAF, JUN

Compounds for genes affiliated with Sarcoma

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligonucleotide4411.8PATZ1, JUN, BRAF, EWSR1, FLI1, SSX2
2Regorafenib1110.9KIT, BRAF
3geldanamycin44 49 59 1113.8KIT, BRAF, JUN

GO Terms for genes affiliated with Sarcoma

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16Gene Ontology
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Cellular components related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.6ASPSCR1, EWSR1, FLI1, SSX6, SSX7, SSX2B

Biological processes related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.9PATZ1, EWSR1, FLI1, SSX6, SSX7, SSX2B
2regulation of transcription, DNA-dependentGO:00635512.4SSX2B, SSX7, SSX6, EWSR1, SSX4B, SSX5
3response to radiationGO:00931410.9KIT, JUN
4megakaryocyte developmentGO:03585510.8FLI1, KIT
5regulation of cell motilityGO:200014510.6SSX2IP, FES

Molecular functions related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367611.8SSX9, SSX6, SSX7, SSX2B, SSX4B, SSX5
2RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.9FLI1, JUN

Products for genes affiliated with Sarcoma

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Sources for Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet