MCID: SRC014
MIFTS: 54

Sarcoma malady

Summaries for Sarcoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from embryonic mesoderm.

MalaCards: Sarcoma, also known as connective and soft tissue neoplasm, is related to synovial sarcoma and clear cell sarcoma. An important gene associated with Sarcoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Transcriptional misregulation in cancer and Sorafenib Pharmacodynamics. The drugs thiotepa and ifosfamide and the compounds oligonucleotide and Regorafenib have been mentioned in the context of this disorder.

Wikipedia:64 A sarcoma (from the Greek σάρξ sarx meaning \"flesh\") is a cancer that arises from transformed... more...

Aliases & Classifications for Sarcoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

sarcoma 8 10 45 61
connective and soft tissue neoplasm 8
tumor of soft tissue and skeleton 8


External Ids:

Disease Ontology8 DOID:1115
SNOMED-CT57 187985009, 93765001
ICD9CM27 171, 171.9

Related Diseases for Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 674)
idRelated DiseaseScoreTop Affiliating Genes
1synovial sarcoma31.7SSX2, KIT, SSX3, SSX1, SS18, SSX4
2clear cell sarcoma31.5EWSR1, BRAF, KIT
3acute leukemia30.9EWSR1, KIT
4neuroepithelioma30.3EWSR1, FLI1
5kidney hemangiopericytoma29.5SSX2, SS18
6kaposi's sarcoma11.3
7soft tissue sarcoma11.2
8endometrial stromal sarcoma11.0
9alveolar soft part sarcoma11.0
10uterine sarcoma10.9
11myeloid sarcoma10.9
12histiocytic sarcoma10.8
13spindle cell sarcoma10.8
14embryonal sarcoma10.8
15follicular dendritic cell sarcoma10.8
16kidney clear cell sarcoma10.7
17classic kaposi sarcoma10.7
18monophasic synovial sarcoma10.6
19primary effusion lymphoma10.6
20castleman's disease10.6
21interdigitating dendritic cell sarcoma10.6
22small cell sarcoma10.6
23bone ewing's sarcoma10.6
24langerhans cell sarcoma10.5
25biphasic synovial sarcoma10.5
26brain sarcoma10.5
27acute myeloid leukemia10.5
28multicentric castleman’s disease10.5
29multicentric castleman disease10.5
30mast-cell sarcoma10.5
31fibrous histiocytoma10.5
32skin sarcoma10.5
33vagina sarcoma10.5
34acquired immunodeficiency syndrome10.4
35pleomorphic undifferentiated sarcoma10.4
36bladder sarcoma10.4
37penis sarcoma10.4
38thyroid sarcoma10.4
39extraskeletal ewing sarcoma10.4
40botryoid rhabdomyosarcoma10.4
41endemic kaposi sarcoma10.3
42hypoxia10.3
43pemphigus10.3
44desmoplastic small round cell tumor10.3
45pleomorphic malignant fibrous histiocytoma10.3
46rhabdoid tumor10.3
47angiomatosis10.3
48gastrointestinal stromal tumor10.3
49spindle cell synovial sarcoma10.3
50adenocarcinoma10.3

Graphical network of the top 20 diseases related to Sarcoma:



Diseases related to sarcoma

Clinical Features for Sarcoma

Drugs & Therapeutics for Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sarcoma

Drug clinical trials:

Search ClinicalTrials for Sarcoma

Search NIH Clinical Center for Sarcoma

Search CenterWatch for Sarcoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Sarcoma

Anatomical Context for Sarcoma

Animal Models for Sarcoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Sarcoma

Sources:
51PubMed
See all sources

Articles related to Sarcoma:

(show top 50)    (show all 7813)
idTitleAuthorsYear
1
Penile Kaposi's sarcoma in a HIV negative HHV-8 positive man. (23935358)
2013
2
Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation. (23990779)
2013
3
Genetic analysis of the fused in sarcoma gene in Chinese Han patients with essential tremor. (23582660)
2013
4
Primary malignant sarcomatoid mesothelioma in the pericardium. (23318857)
2013
5
Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis. (23914101)
2013
6
Alveolar soft-part sarcoma with synchronous bone metastasis: Rare manifestation of one of the least common soft-tissue sarcomas. (24376336)
2013
7
The clinical implication of SS18-SSX fusion gene in synovial sarcoma. (24022186)
2013
8
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. (22595799)
2012
9
Complications following reconstruction of soft-tissue sarcoma: importance of early participation of the plastic surgeon. (21629048)
2012
10
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal sarcomatosis. (22302269)
2012
11
Expression of DcR3 and its effects in kaposi's sarcoma-associated herpesvirus-infected human endothelial cells. (21293109)
2012
12
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. (22710833)
2012
13
Effective treatment of Kaposi's sarcoma by electrochemotherapy and intravenous bleomycin administration. (22741941)
2012
14
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. (22090111)
2012
15
A case of primary central nervous system histiocytic sarcoma. (22425463)
2012
16
High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial. (21652583)
2012
17
Proximal Subungual Onychomycosis in a Patient with Classic Kaposi Sarcoma Caused by Trichophyton rubrum. (22028554)
2011
18
Cardiac synovial sarcoma swinging through the aortic valve. (21871320)
2011
19
Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. (21373757)
2011
20
Epithelioid sarcoma and squamous cell carcinoma arising in a burn scar. (22121287)
2011
21
Interdigitating dendritic cell sarcoma following adult liver transplantation: case report and literature review. (21052884)
2011
22
Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. (19584288)
2009
23
Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone. (19926586)
2009
24
Multifocality in retroperitoneal sarcoma: a prognostic factor critical to surgical decision-making. (19106689)
2009
25
Primary epithelioid sarcoma of the oesophagus. (17624553)
2007
26
The evolution of collagen expression in sarcomatoid renal cell carcinoma. (17521699)
2007
27
Toxicity and outcomes associated with surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with sarcomatosis. (17541691)
2007
28
Autopsy case of sarcomatoid malignant pleural mesothelioma]. (17087333)
2006
29
Prognostic significance of augmented metallothionein (MT) expression correlated with Ki-67 antigen expression in selected soft tissue sarcomas. (15578426)
2005
30
Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. (15929003)
2005
31
Primary gastric histiocytic sarcoma in a dog--a case report. (15533119)
2004
32
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. (12620408)
2003
33
Cerebellar metastasis from clear cell sarcoma of the kidney. A case report with immunohistochemistry. (11912476)
2001
34
Extraskeletal Ewing's sarcoma of the nose. (11233634)
2001
35
Complete non-puerperial uterine inversion as a result of a uterine sarcoma. (11076223)
2000
36
The genomic breakpoint and chimeric transcripts in the EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma. (9858836)
1998
37
Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in soft tissue sarcoma. Is prognostic significance histotype-specific? (8546844)
1995
38
Prolonged stabilization of progressive endometrial stromal sarcoma with prolonged oral etoposide therapy. (7622117)
1995
39
VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. (1281143)
1992
40
Osteogenic sarcoma and Rothmund Thomson syndrome. (1583068)
1992
41
Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. (1755102)
1991
42
Epithelial profile of epithelioid sarcoma. An immunohistochemical analysis of eight cases. (3539305)
1987
43
Sarcoma development following irradiation of acanthomatous epulis in two dogs. (3461611)
1986
44
Histiocytic sarcoma in Wistar rats. A light microscopic, immunohistochemical, and ultrastructural study. (6383258)
1984
45
Alveolar soft-part sarcoma of the orbit. (7322485)
1981
46
Alveolar soft part sarcoma in the vagina: clinical features and morphology. (7372195)
1980
47
Radiation therapy in alveolar soft part sarcoma. (5096923)
1971
48
Embryonal sarcoma of the lung. A case report with a discussion regarding its morphogenesis. (5782410)
1969
49
Viscero-cutaneous angiomatosis with dysproteinaemic phagocytosis: its relation to Kaposi's sarcoma and lymphoproliferative disorders. (5336784)
1966
50
Alveolar soft part sarcoma of the retroperitoneum. (13561117)
1958

Genetic Variations for Sarcoma

Expression for genes affiliated with Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sarcoma

Search GEO for disease gene expression data for Sarcoma.

Pathways for genes affiliated with Sarcoma

Sources:
30KEGG, 50PharmGKB, 60Tocris Bioscience, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9ASPSCR1, SSX1, SS18, SSX2B, SSX2, FLI1
2
Hide members
11.1BRAF, KIT, JUN
3
Hide members
11.1JUN, BRAF, KIT
410.9BRAF, JUN

Compounds for genes affiliated with Sarcoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligonucleotide4511.8PATZ1, JUN, BRAF, EWSR1, FLI1, SSX2
2Regorafenib1110.9KIT, BRAF
3geldanamycin45 50 60 1113.8KIT, BRAF, JUN

GO Terms for genes affiliated with Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.6ASPSCR1, EWSR1, FLI1, SSX6, SSX7, SSX2B

Biological processes related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635112.9PATZ1, EWSR1, FLI1, SSX6, SSX7, SSX2B
2regulation of transcription, DNA-dependentGO:00635512.4SSX2B, SSX7, SSX6, EWSR1, SSX4B, SSX5
3response to radiationGO:00931410.9JUN, KIT
4megakaryocyte developmentGO:03585510.8FLI1, KIT
5regulation of cell motilityGO:200014510.6SSX2IP, FES

Molecular functions related to Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367611.8SSX6, SSX7, SSX2B, SSX4B, SSX5, SSX1
2RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.9JUN, FLI1

Products for genes affiliated with Sarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet