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MCID: SRC014

Sarcoma malady
25 drugs, 1162 genes, 32 tissues, 1669 related diseases, 29 phenotypes, 2083 articles, clinical trials.

Summaries for Sarcoma

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6Disease Ontology, 44Wikipedia, 22MalaCards
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Disease Ontology: A cell type cancer that has material basis in abnormally proliferating cells derived from embryonic mesoderm.6

MalaCards: Sarcoma, also known as connective and soft tissue neoplasm, is related to carcinoma and leukemia. An important gene associated with Sarcoma is SSX2 (synovial sarcoma, X breakpoint 2), and among its related pathways are Endocytosis and Nanog in Mammalian ESC Pluripotency. The drugs dexamethasone and ifosfamide and the compounds sialic acid and inositol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are skeleton and homeostasis/metabolism.

Wikipedia: A sarcoma (from the Greek sarx (σάρκα) meaning \"flesh\") is a cancer that arises from transformed...44 more...

Aliases & Descriptions for Sarcoma

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6Disease Ontology, 7diseasecard, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 40SNOMED-CT
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Aliases & Descriptions:

sarcoma 6 7 8 32 43
connective and soft tissue neoplasm 6
tumor of soft tissue and skeleton 6
neoplasms 43

External Ids:

ICD9CM19 171.9, 171

Related Diseases for Sarcoma

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13GeneCards, 14GeneDecks
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Diseases related to sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1666)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma189.3ZNF384, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
2leukemia163.3ZNF384, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
3prostatitis155.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
4melanoma145.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
5adenocarcinoma140.4PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIK3C3
6neuronitis135.1ZNF395, ZNF384, PIK3CB, PIK3CD, PIK3CA, PIK3R2
7colorectal cancer130.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
8hepatocellular carcinoma129.6ZNF384, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG
9ovarian cancer126.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1
10pancreatitis126.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
11thyroiditis124.8PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCAM1
12cervicitis115.5ZNF384, PIK3CA, PIK3CG, PDE4A, RECK, RELA
13gastric cancer114.4PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, RECK
14breast carcinoma113.2PIK3CA, PIK3R1, PIK3CG, NCOA3, RECK, KIT
15neuroblastoma110.7PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1
16esophagitis110.0PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, NCAM1
17colon cancer109.5PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCAM1, PDE4A
18hypoxia109.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3C2A
19myeloid leukemia106.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIAS4
20arthritis102.9ZNF395, PIK3CD, PIK3CG, PDE4A, RECK, RELA
21rheumatoid arthritis97.4PIK3CD, PIK3CG, PDE4A, RECK, RELA, RELB
22myeloma96.7PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1, PDE4A
23adenoma96.5PIK3CA, NCAM1, NCOA1, NCOA3, PDE4A, RECK
24osteosarcoma95.0ZNF395, PIK3CB, PIK3CA, PIK3CG, NCOA1, PDE4A
25squamous cell carcinoma94.4PIK3CB, PIK3CA, NCOA3, RECK, RELA, VTN
26ovarian carcinoma94.2PIK3CA, PIK3CG, NCOA3, RECK, RELA, KIT
27cervical cancer90.8PIK3CA, PIK3CG, RELA, VTN, PCNA, RB1
28fibrosis89.2PIK3CA, PIK3CG, NCOA3, PDE4A, RECK, RELA
29retinoblastoma88.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1
30soft tissue sarcoma87.1KIT, KITLG, PCNA, GCLC, RB1, RBL2
31acute myeloid leukemia86.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
32lung carcinoma86.6PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK, SFTPB
33astrocytoma85.6PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK, RELA
34colon carcinoma85.3PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCAM1
35lymphocytic leukemia83.6PIK3CD, PIK3CA, PIK3CG, NCAM1, PDE4A, RECK
36cerebritis82.7PIK3R1, PIK3C2A, PIK3CG, NCAM1, PDE4A, RELA
37lymphoblastic leukemia82.0ZNF384, PIK3CA, PIK3CG, NCAM1, NCOA3, RECK
38atherosclerosis76.1PIK3C2A, PIK3CG, PDE4A, RECK, REN, VWF
39epithelial ovarian cancer76.0PIK3CB, PIK3CA, PIK3CG, NCOA1, NCOA3, RELA
40meningioma76.0PIK3CG, NCAM1, NCOA3, RET, PCNA, RB1
41cervical carcinoma74.4ZNF384, PIK3CA, PIK3CG, RECK, RELA, KIT
42rhabdomyosarcoma74.1NCAM1, NCOA1, NCOA3, KITLG, PCNA, RB1
43acute leukemia74.0ZNF384, PIK3CA, NCAM1, REN, KIT, KITLG
44ischemia72.6PIK3CA, PIK3C2A, PIK3CG, NCAM1, PDE4A, RELA
45tuberculosis71.8PIK3CG, PIK3C3, RELA, RELB, KIF3A, SFPQ
46peritonitis71.6PIK3C2A, RELA, RELB, REN, RET, KIT
47pulmonary disease70.3PIK3CG, NCOA3, PDE4A, REN, RET, VWF
48laryngitis70.2PIK3CA, RELA, PCNA, RB1, SETD2, SERPINB5
49thyroid carcinoma69.8PIK3CA, PIK3CG, RET, KITLG, PCNA, RB1
50esophageal cancer68.0PIK3CB, PIK3CA, PIK3CG, KITLG, PCNA, RB1

Graphical network of the top 20 diseases related to sarcoma:



Graphical network of diseases related to sarcoma

Clinical Features for Sarcoma

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Drugs & Therapeutics for Sarcoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 bleomycin, bleomycin sulfate, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], doxorubicin hydrochloride, ifosfamide, linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, mitoxantrone, mitoxantrone hydrochloride, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], thiotepa

Genetic Tests for Sarcoma

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Anatomical Context for Sarcoma

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22MalaCards
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MalaCards organs/tissues related to sarcoma:

22
Bone marrow, Whole blood, Lymph node, Spleen, Brain, Spinal cord, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Uterus, Prostate, Testis, Cervix, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Appendix, Pituitary, Testis germ

Phenotypes for genes affiliated with Sarcoma

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25MGI
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MGI Mouse Phenotypes related to sarcoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1skeleton phenotypeMP:0005390INFZNF384, PIK3CD, PIK3CG, NCOA1, RECK, RELA
2homeostasis/metabolism phenotypeMP:0005376INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
3mortality/agingMP:0010768INFPIK3CB, PIK3CA, PIAS4, PIK3C2A, PIK3C3, NCAM1
4endocrine/exocrine gland phenotypeMP:0005379INFZNF384, NCOA1, RELB, RET, BUB1, RBL2
5craniofacial phenotypeMP:0005382INFNCOA3, KIT, KITLG, KIF3A, BRD4, MYCN
6renal/urinary system phenotypeMP:0005367INFNCOA1, NCOA3, REN, RET, KIT, KIF3A
7behavior/neurological phenotypeMP:0005386INFPIK3CA, PIK3C3, NCAM1, NCOA1, NCOA3, RELB
8cardiovascular system phenotypeMP:0005385INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
9integument phenotypeMP:0010771INFPIK3C2B, PIK3CG, NCOA1, NCOA3, RECK, RELA
10reproductive system phenotypeMP:0005389INFZNF384, PIK3CA, NCOA1, NCOA3, REN, RET
11digestive/alimentary phenotypeMP:0005381INFNCOA3, RELB, RET, KIT, KITLG, KIF3A
12growth/size phenotypeMP:0005378INFZNF384, PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
13muscle phenotypeMP:0005369INFPIK3CA, PIK3R2, PIK3R1, PIK3CG, PIK3C3, NCOA3
14embryogenesis phenotypeMP:0005380INFPIK3CB, PIK3CA, PIK3C3, NCOA1, NCOA3, RECK
15respiratory system phenotypeMP:0005388INFRELB, RET, KIF3A, SFRP4, RBPJ, SELP
16immune system phenotypeMP:0005387INFPIK3CD, PIAS4, PIK3C3, SH2D1B, NCOA1, NCOA3
17nervous system phenotypeMP:0003631INFNCOA1, PDE4A, RECK, RELA, REN, KIT
18hematopoietic system phenotypeMP:0005397INFPIAS4, KIT, PCNA, BUB1, RBPJ, RBM15
19liver/biliary system phenotypeMP:0005370INFPIK3C3, NCOA3, RECK, RELB, KIT, BUB1
20no phenotypic analysisMP:0003012INFPIK3CD, PIK3R1, PIK3C2B, RET, PCNA, BUB1
21vision/eye phenotypeMP:0005391INFPIK3CA, NCAM1, RELA, KIT, KITLG, KIF3A
22normal phenotypeMP:0002873INFPIK3R1, PIK3C3, RELA, REN, RET, VTN
23adipose tissue phenotypeMP:0005375INFPIK3CA, PIK3R1, PIK3C2A, NCOA3, RB1, SERPINE1
24pigmentation phenotypeMP:0001186INFKIT, KITLG, RB1, RBPJ, SERPINC1, BRAF
25limbs/digits/tail phenotypeMP:0005371INFRECK, RELA, RELB, RET, KIT, KITLG
26cellular phenotypeMP:0005384INFPIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIK3C3
27hearing/vestibular/ear phenotypeMP:0005377INFNCOA3, KIT, KITLG, RB1, VDR, MYC
28tumorigenesisMP:0002006INFPIK3CB, PIK3CA, PIK3R2, PIK3R1, NCOA3, RET
29other phenotypeMP:0005395INFRECK, RELB, BUB1, SERPINH1, VASP, RARA

Publications for genes affiliated with Sarcoma

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35PubMed
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Articles related to sarcoma:

(show top 50)    (show all 2083)
idTitleAuthorsYearAffiliating Genes
1Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas. (21493758)Thway K.... Shipley J.2011GPC3
2Cycleave polymerase chain reaction method is practica lly applicable for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)/ V-raf murine sarcoma viral oncogene homolog B1 (BRAF) genotyping in colorectal cancer. (20627194)Yokota T.... Yatabe Y.2010BRAF, KRAS
3Spindle cells from AIDS-associated Kaposi's sarcoma l esions express telomerase activity that is enhanced by Kaposi's sarcoma progres sion factors. (20514465)Barillari G.... Ensoli B.2010IFNG, TAT
4Detection of SYT and EWS gene rearrangements by dual- color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor. (20660338)Kumagai A.... Fukusato T.2010EWSR1, SS18
5Frequent methylation of RASSF1A in synovial sarcoma a nd the anti-tumor effects of 5-aza-2'-deoxycytidine against synovial sarcoma ce ll lines. (19578875)Numoto K.... Ozaki T.2010RASSF1
6Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. (18973917)Kohashi K.... Tsuneyoshi M.2009SMARCB1
7Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. (19194282)Al-Daraji W.I.... Fanburg-Smith J.C.2009KRT18, MYOD1, MYOG
8Re: Infrequent SMARCB1/INI1 gene alteration in epithe lioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from maligna nt rhabdoid tumor: Direct evidence of mutational inactivation of SMARCB1/INI1 i n epithelioid sarcoma. (19683621)Flucke U.... Hulsebos T.J.2009SMARCB1
9Human immunodeficiency virus type 1 Tat accelerates K aposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transf ormed fibroblasts in vitro as well as in nude and immunocompetent mice. (20019835)Chen X.... Lu C.2009TAT
10Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group. (19141382)Chbani L.... Coindre J.M.2009SMARCB1
11Sarcoma of follicular dendritic cells with features of sinus lining cells--a new subtype of reticulum cell sarcoma? (18386053)Krokowski M.... Feller A.C.2008LYVE1
12Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. (17363602)Shor A.C.... Jove R.2007SRC
13Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease. (17262705)Marshall V.... Whitby D.2007KRT15
14Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. (17721195)Guillou L.... Coindre J.M.2007FUS, CREB3L2, CREB3L1
15Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies. (16220269)O'Donnell P.... Flanagan A.M.2006SSX1, SS18
16Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma. (16528378)Olsen S.H.... Lucas D.R.2006BCL2, MUC1, NGFR
17Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. (16557275)Izumi T.... Tsuneyoshi M.2006FXYD5
18A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma. (15767342)Brown E.E.... Chanock S.J.2005FCGR3A
19A general aspect on soft-tissue sarcoma and c-kit expression in primitive neuroectodermal tumor and Ewing's sarcoma. Is there any role in disease process? (16127511)Kara I.O.... Erdogan S.2005KITLG
20Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. (15551306)Seidel C.... Dammann R.2005MSH2, MLH1
21Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but not in a mt-p53 sarcoma cell line. (15583820)Kappler M.... Bache M.2005BIRC5
22Low-grade sarcomas with CD34-positive fibroblasts and low-grade myofibroblastic sarcomas. (15764578)Fisher C.2004ALK
23Targeting other abnormal signaling pathways in sarcoma: EGFR in synovial sarcomas, PPAR-gamma in liposarcomas. (15217223)Blay J.Y.... RanchA"re D.2004PPARG
24Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide. (15217956)Thallinger C.... Selzer E.2004BCL2, MCL1
25Ewing sarcoma/peripheral primitive neuroectodermal tumor: adult abdominal tumors with an Ewing sarcoma gene rearrangement demonstrated by fluorescence in situ hybridization in paraffin sections. (15354743)Gardner L.J.... Dunphy C.H.2004EWSR1
26Epithelioid sarcoma: an immunohistochemical analysis evaluating the utility of cytokeratin 5/6 in distinguishing superficial epithel ioid sarcoma from spindled squamous cell carcinoma. (12641789)Lin L.... Goldblum J.R.2003MUC1
27Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines. (14553943)Moritake H.... Nunoi H.2003PTK2
28Expression of E-cadherin and p53 proteins in human soft tissue sarcomas. (11800644)Yoo J.... Kim B.K.2002TP53
29Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions. (11836434)Widmer I.... Erb P.2002BCL2
30Biphenotypic sarcoma with characteristics of both a Ewing sarcoma and a desmoplastic small round cell tumor. (10842247)Rosoff P.M.... West D.C.2000EWSR1
31Synovial sarcoma. A Scandinavian Sarcoma Group project. (10862210)Skytting B.2000SS18, SSX2
32Implication of TNF receptor-I-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation in growth of AIDS-associated Kaposi's sarcoma cells: a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in Kaposi's sarcoma cells. (10092829)Murakami-Mori K.... Nakamura S.1999MAPK3, TNF
33Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma. (9565343)Kuhnen C.... MA1ller K.M.1998MET
34Endogenous basic fibroblast growth factor is essential for cyclin E-CDK2 activity in multiple external cytokine-induced proliferation of AIDS-associated Kaposi's sarcoma cells: dual control of AIDS-associated Kaposi's sarcoma cell growth and cyclin E-CDK2 activity by endogenous and external signals. (9712033)Murakami-Mori K.... Nakamura S.1998FGF1, FGF2, OSM
35Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. (9890264)Lee S.H.... Yoo N.J.1998FASLG
36Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. (9675593)Jensen V.... Jensen O.M.1998BCL2
37Enhancement of gp130-mediated tyrosine phosphorylation of STAT3 and its DNA-binding activity in dexamethasone-treated AIDS-associated Kaposi's sarcoma cells: selective synergy between dexamethasone and gp130-related growth factors in Kaposi's sarcoma cell proliferation. (9164976)Murakami-Mori K.... Nakamura S.1997STAT3, IL6R, OSM
38Ifosfamide and continuous infusion etoposide in advan ced adult soft tissue sarcoma. A Scandinavian Sarcoma Group Phase II Study. (9389914)Saeter G.... Hannisdal E.1997CSF3
39Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in situ hybridization. (8892591)Hirakawa N.... Tsuneyoshi M.1996BCL2
40Expression of sarcoma-associated antigens p102 and p2 00 in human sarcoma cell lines. (8702231)Song S.... Das Gupta T.D.1996COPB2
41Expression of the CD34 antigen distinguishes Kaposi's sarcoma from pseudo-Kaposi's sarcoma (acroangiodermatitis). (8745885)Kanitakis J.... Claudy A.1996CD34
42Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas. (8527390)Forus A.... van Kessel A.G.1995CDK4, MDM2
43Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. (7585651)Risinger J.I.... Barrett J.C.1995MLH1
44Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene. (7882340)Sorensen P.H.... Triche T.J.1995EWSR1
45Granulocyte-macrophage colony-stimulating factor allows safe escalation of dose-intensity of chemotherapy in metastatic adult soft tissue sarcomas: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. (8418226)Steward W.P.... Tueni E.1993CSF2
46Establishment of a novel granulocytic sarcoma cell line which can adhere to dermal fibroblasts from a patient with granulocytic sarcoma in dermal tissues and myelofibrosis. (1419799)Kobayashi M.... Morioka M.1992MPO
47VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. (1281143)Mattila P.... Renkonen R.1992ITGA4
48MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. (1848471)Ambros I.M.... Salzer-Kuntschik M.1991CD99
49Doxorubicin plus ifosfamide with rhGM-CSF in the trea tment of advanced adult soft-tissue sarcomas: preliminary results of a phase II study from the EORTC Soft-Tissue and Bone Sarcoma Group. (1795008)Steward W.P.... van Glabbeke M.1991CSF1
50Keratin subsets in spindle cell sarcomas. Keratins are widespread but synovial sarcoma contains a distinctive keratin polypeptide pattern and desmoplakins. (1704194)Miettinen M.1991KRT8, DSP, KRT7

Expression for genes affiliated with Sarcoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Sarcoma

Pathways for genes affiliated with Sarcoma

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20KEGG, 36QIAGEN, 41Thomson Reuters, 3Cell Signaling Technology, 10EMD Millipore, 37R&D Systems, 34PharmGKB, 38Reactome
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Pathways related to sarcoma according to GeneDecks:

(show top 50)    (show all 374)
idPathwayScoreTop Affiliating Genes
1Endocytosis20INFRET, KIT, VPS25, CLTA, KDR, LDLR
2Nanog in Mammalian ESC Pluripotency36INFKIT, KITLG, BRAF, VEGFB, VEGFC, LMTK3
3Paxillin Interactions36INFPIK3R2, PIK3R1, KIT, KITLG, VEGFB, VEGFC
4Rac1 Pathway36INFPIK3R2, PIK3R1, KITLG, VEGFB, BMP1, BMP4
5JAK-STAT Pathway36INFPIK3R2, PIK3R1, KIT, KITLG, BRCA1, VEGFB
6Phospholipase-C Pathway36INFKIT, KITLG, VEGFB, VEGFC, BMP1, BMP2
7Cellular Apoptosis Pathway36INFPIK3R2, PIK3R1, KIT, KITLG, VEGFB, VEGFC
8Prostate cancer2019.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
9Melanoma2018.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
10Glioblastoma Multiforme3617.8PIK3R2, PIK3R1, RB1, BRAF, RAF1, RAC1
11Chronic myeloid leukemia2017.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
12Development_VEGF signaling via VEGFR2 - generic cascades4116.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
13Angiogenesis315.9RECK, REN, SERPINB5, VEGFB, VEGFC, KDR
14Leishmaniasis2015.6RELA, JUN, JAK1, JAK2, ITGA4, ITGB1
15Leukocyte transendothelial migration2015.5PIK3CB, PIK3CD, PIK3R2, PIK3R1, PIK3CG, VCAM1
16Bladder cancer2015.5RB1, BRAF, VEGFA, VEGFB, VEGFC, MYC
17Development FGFR signaling pathway1015.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
18PDGF Pathway3615.1PIK3R2, PIK3R1, RAF1, RAC1, CHUK, JUN
19LPS Stimulated MAPK Signaling3614.9PIK3R2, PIK3R1, RAF1, RAC1, CHUK, ATF1
20TRAF Pathway3614.9PIK3R2, PIK3R1, CHUK, UBC, JUN, FOS
21Germ Cell-Sertoli Cell Junction Dynamics3614.9PIK3R2, RAC1, BCAR1, AXIN1, JUP, ITGB1
22Ceramide Pathway3614.7PIK3R2, PIK3R1, RAF1, BAD, ATF6, ATF1
23Cell adhesion molecules (CAMs)2014.7NCAM1, SELP, CLDN7, CLDN1, CLDN10, SDC1
24Immune response_BCR pathway4114.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
25CD28 Signaling in T-Helper Cell3614.4PIK3R1, PIK3C2B, PIK3C2G, PIK3C2A, PIK3C3, RAC1
26FLT3 Signaling3614.4PIK3R2, PIK3R1, BRAF, RAF1, BCL2, BAD
27Immune response_MIF in innate immunity response4114.2RELA, CHUK, CEBPB, JUN, CD14, MIF
28Development_ERBB-family signaling4114.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELB
29Transcription_Receptor-mediated HIF regulation4114.0PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VEGFA
30Apoptosis Signaling Pathways3713.9BIRC5, BCL2, BCL2L1, YWHAE, YWHAQ, BAD
31Development_Angiopoietin - Tie2 signaling4113.8PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
32Sorafenib Pharmacodynamics3413.8PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B, PIK3C2A
33Progesterone-mediated oocyte maturation2013.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
34Cell cycle_Regulation of G1/S transition (part 2)4113.6RELA, RB1, RBL2, CHUK, JUN, CDK6
35Cell surface interactions at the vascular wall3813.6PIK3CB, PIK3CA, PIK3R1, SELP, BSG, LCK
36Allograft rejection2013.1CD28, CD40LG, CD40, IL10, IL12A, IL2
37Transcription P53 signaling pathway1013.1RELA, RELB, VEGFA, CDK2, CDKN2A, MAPK8
38Signal transduction_PTEN pathway4112.1PCNA, BCAR1, ITGA5, ITGB1, GSK3B, IGF1R
39Signal transduction AKT signaling1011.8PIK3CB, PIK3CD, PIK3R2, PIK3R1, RELB, GSK3B
40EGFR Inhibitor Pathway, Pharmacodynamics3411.6CAMK1D, HRAS, NRAS, NFKB2, KRAS, STAT2
41Development EGFR signaling pathway1011.2CBL, EREG
42IL-6 Pathway36INFPIK3R2, PIK3R1, BRAF, BMP1, BMP2, BMP4
43Neurotrophin signaling pathway20INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3CG, RELA
44p53 signaling pathway20INFSERPINB5, SERPINE1, CHEK2, BAX, ATM, CDK6
45Transendothelial Migration of Leukocytes36INFPIK3R2, PIK3R1, VCAM1, RAC1, CLDN7, CLDN1
46MAPK Signaling36INFPIK3R2, PIK3R1, KIT, KITLG, BRAF, VEGFB
47MIF Regulation of Innate Immune Cells36INFBMP1, BMP2, BMP4, BMP6, BMP7, BCL2
48Activation of PKA through GPCR36INFKIT, KITLG, BRAF, VEGFB, VEGFC, LMTK3
49Development VEGF-family signaling10INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, VTN
50MIF Mediated Glucocorticoid Regulation36INFBMP1, BMP2, BMP4, BMP6, BMP7, BCL2

Compounds for genes affiliated with Sarcoma

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Sources:
32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
See all sources

Compounds related to sarcoma according to GeneDecks:

(show top 50)    (show all 406)
idCompoundScoreTop Affiliating Genes
1sialic acid32 INFNCAM1, RECK, SERPINA3, CLU, PAEP, BCR
2inositol32 INFPIK3CB, PIK3CD, PDE4A, LPL, BCR, CHGA
3phospholipid32 INFPIK3R1, PDE4A, VWF, , SERPINA1, LPL
4serine32 INFPIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCAM1
5dexamethasone32 42 34 9 9 INFPIK3CA, PIK3R1, NCAM1, PDE4A, REN, KITLG
6pge232 INFPDE4A, REN, VTN, , SELE, SETD2
7estrogen32 INFPIK3CB, PIK3R1, NCOA1, NCOA3, VWF, PCNA
8doxorubicin32 34 9 9 INFPIK3CA, PIK3C2A, PIK3CG, NCAM1, RECK, KIT
9rantes32 INFKITLG, SELE, SELP, VIP, VCAM1, BMP6
10tgf beta132 22.3KITLG, RBL2, SETD2, SERPINE1, VIM, VCAM1
11methotrexate32 34 42 9 9 25.2PIK3C2A, KIT, KITLG, PCNA, RB1, SELE
12carboplatin32 34 9 9 20.4KITLG, RB1, BRCA1, VEGFA, PARP1, KDR
13p00232 17.3KIT, RB1, SERPINB5, BRAF, BRCA1, BRCA2
14thalidomide32 42 9 9 19.5PDE4A, VTN, VEGFA, BIRC5, KDR, BCL2L1
15dbc-amp32 15.4NCAM1, PDE4A, VIM, VIP, MYCN, BMP4
16indole-3-carbinol32 15.2BRCA1, BRCA2, BIRC5, PARP1, BCL2, BCL2L1
17parthenolide32 14.4PIK3CG, BCL2L1, CHUK, JAK2, MMP9, IL6
182-methoxyestradiol32 18 15.0PCNA, SETD2, BCL2, BCL2L1, UGT1A1, BAX
19methylmethanesulfonate32 13.9PCNA, BRCA1, BRCA2, RAD51, PARP1, XRCC1
20cetuximab32 34 9 9 16.5BRAF, KDR, CDKN1B, CDKN3, FCGR3A, IGF1R
21polyethylene glycol32 13.2KITLG, VTN, SELE, SERPINC1, VIP, BMP2
22polymyxin b32 13.2SELE, SERPINE1, VCAM1, LDLR, CD14, ITGB2
23fenofibrate32 9 9 14.8PIK3C2A, SELE, SELP, SERPINE1, VIM, LPL
24mycophenolate mofetil32 9 9 14.7SELE, SELP, SERPINE1, UGT1A1, CD36, CD40LG
25glucosamine32 9 18 9 15.6SERPINC1, LPL, CD36, CD40, MMP13, MMP3
26manumycin32 12.6RAF1, CHUK, INSR, ANXA5, MAPK8, MAPK14
27il-1232 12.3CD40LG, IL10, IL13, IL15, IL18, IL1B
28salicylic acid32 INFPIK3CG, SERPINA1, VDR, MYC, KDM1A, BCL2L1
29gsno32 INFSELP, SETD2, CEBPB, JUN, CDKN3, FN1
30cyclophosphamide32 34 9 9 INFBCL6, MVP, MS4A1, ITGA4, ITGB2,
31threonine32 INFRET, , RBL2, VASP, MYOD1, BMP2
32methylcellulose32 INFKIT, KITLG, BMP2, CD14, CD34, CDH1
33cyclosporin a32 42 INFPIK3CA, PIK3C2A, PIK3CG, PDE4A, RECK, KITLG
34flavopiridol32 9 9 INFPIK3CG, KIT, RB1, VEGFA, BIRC5, PARP1
35leukotriene b432 42 18 INFPDE4A, GC, SELP, RAC1, MPO, ITGB2
36k252a32 INFPIK3CG, VIM, BCAR1, FGF2, MET, MAPK8
37vegf32 INFPIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCAM1
38forskolin32 42 9 9 INFPIK3R1, PDE4A, REN, VIM, VIP,
39quercetin32 42 9 18 9 INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
40gefitinib32 34 9 9 INFPIK3CA, PIK3CG, KIT, SELP, VIM, VEGFA
41citrate32 INFPIK3C2A, SELP, VDR, MYOD1, BLZF1, SDHB
42erlotinib32 34 9 9 INFPIK3CA, KIT, VEGFA, BIRC5, KDR, MTOR
43vinblastine32 9 9 INFVIM, RAF1, BIRC5, KDR, BCL2, BCL2L1
44cisplatin32 34 9 9 INFPIK3CA, PIK3C2A, KITLG, VTN, PCNA, GCLC
45aspirin32 34 18 INFPDE4A, KITLG, VWF, VTN, PCNA, SELE
46h2o232 INFPIK3CB, PIK3R1, PIK3CG, PDE4A, KITLG, VWF
47vanadate32 INFSETD2, BLZF1, LCK, FYN, JAK1, JAK2
48butyrate32 INFNCOA1, NCOA3, RET, KITLG, PCNA, RB1
49silver32 INFRECK, PCNA, SERPINA3, BLZF1, UNG, CHGA
50Adenosine triphosphate9 18 9 INFPIK3CB, PIK3CD, PIK3CA, PIK3C2B, PIK3C2G, PIK3C2A

GO Terms for genes affiliated with Sarcoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to sarcoma according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:005615INFREN, KIT, KITLG, VTN, SFRP4, SFTPA1
2extracellular regionGO:005576INFNCAM1, KITLG, VWF, VTN, SFTPA1, GC
3membrane raftGO:04512114.1SELE, BSG, BST2, BCL10, SDC4, LCK
4platelet alpha granule lumenGO:03109311.9VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC
5nucleolusGO:005730INFZNF384, PIAS4, NCOA3, PCNA, RBFOX2, RBL2
6cell surfaceGO:009986INFNCAM1, SFRP4, BST2, VEGFA, LPL, VCAM1
7plasma membraneGO:005886INFPIK3CD, PIK3R1, PIK3C2B, PIK3C2A, PIK3CG, NCAM1
8cytosolGO:005829INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
9integral to plasma membraneGO:005887INFRET, SELP, SEMA4D, , VIPR2, BST2
10cytoplasmGO:005737INFZNF395, PIAS4, PIK3C2A, PIK3CG, NCOA3, RELA
11external side of plasma membraneGO:009897INFNCAM1, KIT, VWF, SELP, VCAM1, KDR
12nucleusGO:005634INFZNF81, ZNF395, ZNF426, ZNF41, ZNF182, ZNF384
13nucleoplasmGO:005654INFNCOA1, NCOA3, RELA, SFPQ, PCBP1, PCNA

Biological processes related to sarcoma according to GeneDecks:

(show top 50)    (show all 69)
idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:001525INFPIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
2immune responseGO:006955INFVTN, SERPINB9, SEMA4D, , BMP6, CHUK
3negative regulation of apoptotic processGO:043066INFPIK3CG, RELA, SERPINE1, BRAF, VEGFA, MYC
4positive regulation of cell proliferationGO:008284INFKIT, VIP, , VEGFA, VEGFC, MYC
5organ morphogenesisGO:009887INF, BRAF, VEGFC, VDR, BMP2, PAX3
6negative regulation of cell proliferationGO:008285INFSFRP4, SERPINE2, VDR, BMP2, BMP4, RARB
7protein phosphorylationGO:006468INFPIK3CD, RET, BRAF, BRD4, MYOD1, RARA
8positive regulation of transcription, DNA-dependentGO:04589325.2NCOA1, NCOA3, RELA, RET, RB1, BRCA1
9cell proliferationGO:00828320.3KITLG, PCNA, BUB1, BST2, RAF1, LIG4
10innate immune responseGO:04508720.2PIK3CD, PIK3CG, PIK3C3, RELA, BST2, CLU
11response to drugGO:04249320.1PDE4A, REN, VEGFC, LPL, MYC, BGLAP
12anti-apoptosisGO:00691617.2PIK3CA, RELA, GCLC, SERPINB9, SEMA4D, SERPINB2
13positive regulation of cell migrationGO:03033517.1RET, SEMA4D, VIL1, VEGFA, BMP2, KDR
14insulin receptor signaling pathwayGO:00828616.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PIK3C3
15fibroblast growth factor receptor signaling pathwayGO:00854316.9PIK3CA, PIK3R1, BRAF, RAF1, CHUK, UBC
16platelet activationGO:03016816.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, VWF
17epidermal growth factor receptor signaling pathwayGO:00717316.6PIK3CA, PIK3R1, PIK3C2A, VIL1, RAF1, CLTA
18positive regulation of protein phosphorylationGO:00193416.2SEMA4D, VEGFA, BMP2, BMP4, MTOR, AXIN1
19positive regulation of apoptotic processGO:04306516.2PIAS4, NCOA1, SFRP4, BMP2, BMP4, RARB
20leukocyte migrationGO:05090016.0PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELP, BSG
21induction of apoptosisGO:00691715.5BCL10, LCK, BAD, BAX, CEBPB, CD2
22peptidyl-tyrosine phosphorylationGO:01810815.2KIT, KDR, FYN, JAK1, JAK2, FLT1
23positive regulation of cell divisionGO:05178114.1VEGFA, VEGFB, VEGFC, YBX1, FGF1, FGF2
24positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406814.0KIT, SELP, SEMA4D, KDR, JAK2, FLT1
25positive regulation of MAPK cascadeGO:04341014.0KIT, KDR, LEP, CD36, ITGB1, FLT1
26positive regulation of fibroblast proliferationGO:04814613.6MYC, BMI1, LIG4, XRCC4, S100A6, JUN
27platelet degranulationGO:00257613.6VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFB
28T cell costimulationGO:03129513.6PIK3CA, PIK3R2, PIK3R1, RAC1, LCK, YES1
29phosphatidylinositol-mediated signalingGO:048015INFPIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2B, PIK3C2G
30heart developmentGO:007507INFPCNA, VCAM1, BMP2, RAF1, BCOR, SALL1
31response to hypoxiaGO:001666INF, SERPINA1, VEGFA, VCAM1, BMP2, RAF1
32cell-cell signalingGO:007267INFVIPR2, BST2, BMP2, S100A9, CGA, CGB
33cytokine-mediated signaling pathwayGO:019221INFNCAM1, RELA, KIT, VCAM1, LIFR, UBC
34cell surface receptor signaling pathwayGO:007166INFBSG, LIFR, CLEC2D, BAG1, CD28, CD2
35positive regulation of peptidyl-tyrosine phosphorylationGO:050731INFKITLG, VTN, SEMA4D, VEGFA, VEGFB, MTOR
36signal transductionGO:007165INFPIK3CB, PIK3CD, PDE4A, RET, KIT, KITLG
37positive regulation of ERK1 and ERK2 cascadeGO:070374INFBRAF, VEGFB, BMP2, BMP4, KDR, CD44
38inflammatory responseGO:006954INFPIK3CD, PIK3CG, RELA, KIT, SELE, SELP
39virus-host interactionGO:019048INFPIK3R1, RELA, BUB1, RB1, RBM15, RBM15B
40nerve growth factor receptor signaling pathwayGO:048011INFPIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, BRAF
41apoptotic processGO:006915INFBUB1, VIM, BRCA1, RAF1, RAC1, RAD21
42blood coagulationGO:007596INFPIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KIF3A
43negative regulation of transcription, DNA-dependentGO:045892INFPIAS4, RELA, GCLC, RB1, RBFOX2, RBPJ
44positive regulation of endothelial cell proliferationGO:001938INFVEGFA, VEGFB, BMP2, BMP4, BMP6, BMPR2
45negative regulation of transcription from RNA polymerase II promoterGO:000122INFPIAS4, VPS72, RBPJ, SEMA4D, VDR, MYC
46interferon-gamma-mediated signaling pathwayGO:060333INFNCAM1, VCAM1, B2M, JAK1, JAK2, CD44
47positive regulation of transcription from RNA polymerase II promoterGO:045944INFNCOA1, NCOA3, RELA, RB1, RBM14, RBPJ
48cellular response to mechanical stimulusGO:071260INF, BCL10, BAD, CD40, ITGB1, IRF1
49protein autophosphorylationGO:046777INFKIT, KDR, CHEK2, MTOR, ATM, FYN
50response to estradiol stimulusGO:032355INFNCOA1, SFRP4, GC, SERPINA1, BRCA2, VDR

Molecular functions related to sarcoma according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:042803INFKIT, VWF, VIL1, BST2, VEGFA, VEGFB
2sequence-specific DNA bindingGO:043565INFVDR, MYC, RARA, RARB, PAX7, PAX3
3sequence-specific DNA binding transcription factor activityGO:00370025.6ZNF81, ZNF41, RELA, RELB, RB1, RBPJ
4enzyme bindingGO:01989917.7NCOA1, BRCA1, RARA, RAC1, BLZF1, BIRC5
5growth factor activityGO:00808316.8KITLG, VEGFA, VEGFB, VEGFC, BMP1, BMP2
6cytokine activityGO:00512515.7KITLG, VEGFA, BMP1, BMP2, BMP4, BMP6
7protein tyrosine kinase activityGO:00471315.7RET, KIT, LMTK3, KDR, BCR, LCK
8transcription regulatory region DNA bindingGO:04421215.4RELA, BRCA1, PAX8, PAX2, KDM1A, BCOR
9protease bindingGO:00202013.0KIT, VWF, SERPINC1, SERPINB9, SERPINA1, SERPINE1
10identical protein bindingGO:042802INFRELA, PCNA, VIL1, VIM, RAD51, RAF1
11protein bindingGO:005515INFPIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2B
12chromatin bindingGO:003682INFNCOA1, NCOA3, RELA, BRD2, PATZ1, KDM1A
13protein heterodimerization activityGO:046982INFBRAF, VEGFA, VEGFB, MYC, MYOG, MYF6
14protein kinase bindingGO:019901INFRELA, VIM, BCAR1, BCL10, BCL2L1, CHEK2
15heparin bindingGO:008201INFVTN, SELP, SERPINE2, SERPINC1, VEGFA, VEGFB
16transcription factor bindingGO:008134INFRELA, RB1, RBFOX2, MYC, MYOD1, RARA
17transmembrane receptor protein tyrosine kinase activityGO:004714INFRET, KIT, KDR, AXL, FLT1, FLT4
18ATP bindingGO:005524INFPIK3CB, PIK3CD, PIK3CA, PIK3C2B, PIK3C2G, PIK3C2A

Sources for Sarcoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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