MCID: SCB001
MIFTS: 58

Scabies malady

Infectious diseases category

Summaries for Scabies

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9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can sometimes spread scabies. this can happen much more easily when the infested person has crusted scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards: Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to bullous pemphigoid and leukemia. An important gene associated with Scabies is CFP (complement factor properdin), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The drugs ivermectin and lindane and the compounds antistasin and benzidine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC:4 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia:66 Scabies (from Latin: scabere, \"to scratch\"), also known colloquially as the seven-year itch, is a... more...

Aliases & Classifications for Scabies

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9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

scabies 9 11 35 63
infestation by sarcoptes scabiei var hominis 9
infestation by sarcoptes scabiei 9
sarcoptic itch 9


External Ids:

Disease Ontology9 DOID:8295
ICD9CM28 133.0
MeSH36 D012532
NCIt41 C34998
ICD1026 B86

Related Diseases for Scabies

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18GeneCards, 19GeneDecks
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Diseases related to Scabies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1bullous pemphigoid30.6DST
2leukemia30.4CSF3, KITLG, GSTM1, CCL11
3urticaria30.4IGHE
4atopic dermatitis30.2CCL11
5mastocytosis30.2KITLG, IGHE
6skin disease29.9CCL11, DST, IGHE
7asthma29.8IGHE, GSTM1, KITLG, CCL11
8norwegian scabies11.0
9dermatitis10.3
10psoriasis10.3
11adult t-cell leukemia10.3
12t-cell leukemia10.3
13langerhans-cell histiocytosis10.3
14acquired immunodeficiency syndrome10.3
15histiocytosis10.3
16pyoderma10.3
17granuloma annulare10.1
18allergic contact dermatitis10.1
19contact dermatitis10.1
20eosinophilia10.1
21epidermolysis bullosa10.1
22impetigo10.1
23blindness10.1
24strongyloidiasis10.1IGHE
25conjunctivitis10.1IGHE
26leukemoid reaction10.1CSF3
27allergic conjunctivitis10.1CCL11, IGHE
28eosinophilic gastroenteritis10.1CCL11, IGHE
29eosinophilic pneumonia10.1CCL11, IGHE
30pulmonary eosinophilia10.1CCL11, IGHE
31allergic rhinitis10.1IGHE, CCL11
32food allergy10.1IGHE, CCL11
33vernal keratoconjunctivitis10.1CCL11, IGHE
34hypereosinophilic syndrome10.1CCL11, IGHE
35otitis media10.1IGHE, CCL11
36bronchitis10.1CCL11, IGHE
37gamma chain deficiency10.1CFP, KITLG
38hypersplenism10.1F2
39sinusitis10.1IGHE, CCL11
40bronchiolitis10.1CCL11, IGHE
41respiratory failure10.1CCL11, IGHE
42malaria10.1CFP, GSTM1
43molluscum contagiosum10.1
44lichen planus10.1
45chickenpox10.1
46hailey-hailey disease10.1
47systemic lupus erythematosus10.1
48urticaria pigmentosa10.1
49arthritis10.1
50filariasis10.1

Graphical network of the top 20 diseases related to Scabies:



Diseases related to scabies

Symptoms for Scabies

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Drugs & Therapeutics for Scabies

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Scabies

Drug clinical trials:

Search ClinicalTrials for Scabies

Search NIH Clinical Center for Scabies

Search CenterWatch for Scabies

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Scabies

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Anatomical Context for Scabies

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34MalaCards
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MalaCards organs/tissues related to Scabies:

34
Skin, Breast, T cells, Testes, Kidney, Brain, Colon, Bone, Monocytes, Bone marrow

Animal Models for Scabies or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Scabies:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2KITLG, GSTM1, DST, CFP, IGHE, F2
2MP:00053978.0KITLG, CSF3, CCL11, DST, IGHE, F2
3MP:00053877.8F2, IGHE, CFP, CCL11, CSF3, KITLG

Publications for Scabies

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53PubMed
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Articles related to Scabies:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Norwegian crusted scabies: an unusual case presentation. (24370484)
2014
2
Scabies in the nursing home, misdiagnosis means costs, and embarrassment: story of a centenarian smitten by scabies! (24359700)
2014
3
Treatment and control of scabies. (23438966)
2013
4
Novel insights into an old disease: recent developments in scabies mite biology. (23385639)
2013
5
Ivermectin vs. lindane in the treatment of scabies. (23829057)
2013
6
A novel clinical grading scale to guide the management of crusted scabies. (24069468)
2013
7
Entomodermoscopy in scabies - is it a safe and friendly screening test for scabies in children? (22726288)
2012
8
Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin. (22211573)
2012
9
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
10
Novel scabies mite serpins inhibit the three pathways of the human complement system. (22792350)
2012
11
A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei. (22018936)
2011
12
The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. (21757492)
2011
13
Epidemiology of scabies prevalence in the U.K. from general practice records. (21574970)
2011
14
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). (21182645)
2010
15
Diagnostic usefulness of a nested polymerase chain reaction assay for detecting Sarcoptes scabiei DNA in skin scrapings from clinically suspected scabies. (20560958)
2010
16
Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. (20177574)
2009
17
Variable response of crusted scabies to oral ivermectin: report on eight Egyptian patients. (19309428)
2009
18
Alcohol-based hand rub and nosocomial scabies. (18690789)
2008
19
A scabies outbreak in a further education college in Gloucestershire. (16948878)
2007
20
Interventions for treating scabies. (17636630)
2007
21
Recommendations for the treatment of scabies infestations in Israel. (16599057)
2006
22
Treatment of steroid-resistant nodular scabies with topical pimecrolimus. (16021143)
2005
23
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. (15872307)
2005
24
Crossreacting IgG antibodies against fox mite antigens in human scabies. (15650895)
2005
25
Biotransformation of the Streptomyces scabies phytotoxin thaxtomin A by the fungus Aspergillus niger. (15052314)
2004
26
Scabies: new future for a neglected disease. (15504541)
2004
27
Pyoderma and scabies: a benign association? (12734437)
2003
28
Scabies: a differential diagnosis of pruritus following subarachnoid opioid administration. (14616629)
2003
29
Current treatments for scabies. (12667233)
2003
30
Seasonality trends of scabies in a young adult population: a 20-year follow-up. (12890210)
2003
31
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
32
Crusted (Norwegian) scabies. (11932093)
2002
33
Use of ivermectin, given orally, to control scabies in homes for the elderly mentally ill. (12166302)
2002
34
Factors supporting sustainability of a community-based scabies control program. (12423434)
2002
35
Parasitic skin infestations II, scabies, pediculosis, spider bites: unapproved treatments. (12490354)
2002
36
Dealing with scabies. (12216245)
2001
37
Outcome of an interventional program for scabies in an Indigenous community. (11700814)
2001
38
Scabies presenting as a blistering eruption. (11710447)
2001
39
The use of ivermectin in controlling an outbreak of scabies in a prison. (10971323)
2000
40
Scabies in some workers living in crowded area, Jeddah, Saudi Arabia. (10786043)
2000
41
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. (10617527)
2000
42
Case report: teledermatology and epiluminescence microscopy for the diagnosis of scabies. (10916694)
2000
43
Treatment of human scabies with oral ivermectin. (10564922)
1999
44
Before using ivermectin therapy for scabies. (10632951)
1999
45
Pathogenicity of Streptomyces scabies Mutants Altered in Thaxtomin A Production. (18944924)
1998
46
Crusted (Norwegian) scabies as a pre-diagnostic indicator for HTLV-1 infection. (8236396)
1993
47
Coexistence of unusual scabies and pneumocystosis in a patient without any underlying disease. (6376579)
1984
48
Norwegian scabies: occurrence in a patient undergoing immunosuppression. (822784)
1976
49
Norwegian scabies and lymphatic leukaemia. (6025578)
1967
50
Norwegian scabies (crusted scabies). (13954071)
1963

Variations for Scabies

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Expression for genes affiliated with Scabies

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for genes affiliated with Scabies

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG
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Compounds for genes affiliated with Scabies

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Scabies according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1antistasin4610.2F2, CFP
2benzidine4610.1KITLG, GSTM1
3protamine sulfate4610.1KITLG, F2
4pbhp4610.1CSF3, KITLG
5unicap4610.1CCL11, IGHE
6daniplestim4610.1CSF3, KITLG
7carboxymethylcellulose4610.0CSF3, KITLG
8sodium cromoglycate4610.0IGHE, CCL11
9mafosfamide4610.0KITLG, CSF3
104-hydroperoxycyclophosphamide4610.0CSF3, KITLG
11cetirizine46 30 25 1213.0CCL11, IGHE
12pixy3214610.0KITLG, CSF3
13clarithromycin46 1211.0CCL11, F2
14amifostine46 1210.9CSF3, KITLG
15ketotifen46 1210.9CCL11, IGHE
16filgrastim46 1210.9KITLG, CSF3
17hydroxyethyl starch469.9CSF3, F2
18busulfan46 52 1211.8CSF3, GSTM1
19penicillin469.8F2, IGHE
20anti-histamine469.8KITLG, CCL11, IGHE
21budesonide46 52 1211.8IGHE, CCL11, KITLG
22salbutamol46 52 30 25 1213.8CCL11, KITLG, IGHE
23pgd2469.8IGHE, KITLG, CCL11
24sulfamethoxazole52 46 1211.7GSTM1, IGHE
25styrene oxide469.7GSTM1, CYP20A1
26montelukast46 52 30 1212.7IGHE, CCL11
27carboplatin46 52 1211.7KITLG, GSTM1, CSF3
28aspirin46 52 30 2512.6CCL11, F2, KITLG
29hydroxyurea46 52 1211.6CSF3, F2, KITLG
30styrene469.6GSTM1, CYP20A1
31zidovudine46 52 1211.6CSF3, NT5C, KITLG
32cytarabine46 52 1211.6KITLG, CSF3, NT5C
335fluorouracil469.4CSF3, GSTM1, KITLG
34hydrocarbons469.3CYP20A1, GSTM1
35thymidine46 2510.2KITLG, NT5C, CCL11, CSF3
36lactate469.2KITLG, F2, IGHE, GSTM1
37rantes469.2CSF3, KITLG, CCL11
38creatinine469.2IGHE, KITLG, F2, GSTM1
39cyclophosphamide46 52 1211.2IGHE, CSF3, GSTM1, KITLG
40epinephrine46 25 1211.1F2, IGHE, CSF3, KITLG
41heparin46 30 25 1212.1CFP, IGHE, F2, CCL11, KITLG
42cycloheximide469.1IGHE, DST, CSF3, KITLG
43histamine46 30 2510.9CCL11, IGHE, CYP20A1, KITLG
44prednisolone46 30 1210.9IGHE, KITLG, GSTM1, CSF3, CCL11
45dexamethasone46 52 30 1211.9IGHE, KITLG, CCL11, CSF3
46cyclosporin a46 30 6210.8KITLG, CSF3, CCL11, IGHE, F2
47methotrexate52 46 1210.8KITLG, GSTM1, CSF3, F2, IGHE
48testosterone46 62 25 1211.7IGHE, GSTM1, KITLG, CYP20A1
49superoxide46 259.7KITLG, CSF3, CCL11, CFP, CYP20A1
50vegf468.5IGHE, CCL11, KITLG, CSF3

GO Terms for genes affiliated with Scabies

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17Gene Ontology
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Cellular components related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6IGHE, CFP, CCL11, KITLG, F2
2extracellular spaceGO:0056158.3KITLG, CSF3, CCL11, CFP, F2

Biological processes related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.7DST, F2
2positive regulation of actin filament polymerizationGO:0308389.6CSF3, CCL11
3positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.2CSF3, F2
4immune responseGO:0069558.9CSF3, CCL11, CFP, IGHE
5innate immune responseGO:0450878.7IGHE, CFP, KITLG, CD300E

Molecular functions related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2KITLG, CSF3, F2

Products for genes affiliated with Scabies

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Sources for Scabies

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet