MCID: SCB001
MIFTS: 61

Scabies malady

Infectious diseases category
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Summaries for Scabies

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MedlinePlus:33 Scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can sometimes spread scabies. this can happen much more easily when the infested person has crusted scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards based summary: Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to bullous pemphigoid and urticaria. An important gene associated with Scabies is CFP (complement factor properdin), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The drugs lindane and ivermectin and the compounds antistasin and benzidine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC:3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia:65 Scabies (from Latin: scabere, \"to scratch\"), also known colloquially as the seven-year itch, is a... more...

Aliases & Classifications for Scabies

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Scabies, Aliases & Descriptions:

Name: Scabies 8 10 33 62
Infestation by Sarcoptes Scabiei Var Hominis 8 62
 
Infestation by Sarcoptes Scabiei 8 62
Sarcoptic Itch 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:8295
NCIt39 C34998
MeSH34 D012532
ICD9CM27 133.0
ICD1025 B86

Related Diseases for Scabies

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Diseases related to Scabies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1bullous pemphigoid31.0DST
2urticaria30.9IGHE
3atopic dermatitis30.6CCL11
4mastocytosis30.5KITLG, IGHE
5skin disease30.0CCL11, DST, IGHE
6leukemia29.9CSF3, KITLG, GSTM1, CCL11
7asthma29.7IGHE, GSTM1, KITLG, CCL11
8norwegian scabies11.0
9strongyloidiasis10.5IGHE
10conjunctivitis10.5IGHE
11leukemoid reaction10.4CSF3
12psoriasis10.4
13allergic conjunctivitis10.4CCL11, IGHE
14eosinophilic gastroenteritis10.4CCL11, IGHE
15eosinophilic pneumonia10.3CCL11, IGHE
16pulmonary eosinophilia10.3CCL11, IGHE
17dermatitis10.3
18allergic rhinitis10.3IGHE, CCL11
19food allergy10.3IGHE, CCL11
20vernal keratoconjunctivitis10.3CCL11, IGHE
21hypereosinophilic syndrome10.3CCL11, IGHE
22otitis media10.3IGHE, CCL11
23adult t-cell leukemia10.3
24acquired immunodeficiency syndrome10.3
25t-cell leukemia10.3
26bronchitis10.3CCL11, IGHE
27gamma chain deficiency10.3CFP, KITLG
28sinusitis10.3IGHE, CCL11
29hypersplenism10.3F2
30bronchiolitis10.3CCL11, IGHE
31respiratory failure10.3CCL11, IGHE
32langerhans-cell histiocytosis10.3
33histiocytosis10.3
34pyoderma10.3
35malaria10.3CFP, GSTM1
36rhinitis10.2CCL11, IGHE
37severe congenital neutropenia10.2KITLG, CSF3
38pemphigus vulgaris10.2DST, CCL11
39refractory anemia10.2KITLG, CSF3
40pdgfrb-associated chronic eosinophilic leukemia10.2KITLG, CSF3
41schistosomiasis10.2GSTM1, IGHE
42granuloma annulare10.2
43allergic contact dermatitis10.2
44contact dermatitis10.2
45eosinophilia10.2
46epidermolysis bullosa10.2
47impetigo10.2
48blindness10.2
49afibrinogenemia10.1CFP, F2
50protein c deficiency10.1CFP, F2

Graphical network of the top 20 diseases related to Scabies:



Diseases related to scabies

Symptoms for Scabies

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Drugs & Therapeutics for Scabies

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Drug clinical trials:

Search ClinicalTrials for Scabies

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Scabies

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Anatomical Context for Scabies

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MalaCards organs/tissues related to Scabies:

32
Skin, Breast, T cells, Testes, Brain, Kidney, Bone marrow, Bone, Colon, Monocytes, Neutrophil

Animal Models for Scabies or affiliated genes

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MGI Mouse Phenotypes related to Scabies:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2KITLG, GSTM1, DST, CFP, IGHE, F2
2MP:00053978.0KITLG, CSF3, CCL11, DST, IGHE, F2
3MP:00053877.8F2, IGHE, CFP, CCL11, CSF3, KITLG

Publications for Scabies

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Articles related to Scabies:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Norwegian crusted scabies: an unusual case presentation. (24370484)
2014
2
Scabies in the nursing home, misdiagnosis means costs, and embarrassment: story of a centenarian smitten by scabies! (24359700)
2014
3
Scabies outbreaks in residential care homes: factors associated with late recognition, burden and impact. A mixed methods study in England. (25195595)
2014
4
Crusted scabies. (25129017)
2014
5
Treatment and control of scabies. (23438966)
2013
6
Novel insights into an old disease: recent developments in scabies mite biology. (23385639)
2013
7
Ivermectin vs. lindane in the treatment of scabies. (23829057)
2013
8
A novel clinical grading scale to guide the management of crusted scabies. (24069468)
2013
9
Entomodermoscopy in scabies - is it a safe and friendly screening test for scabies in children? (22726288)
2012
10
Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin. (22211573)
2012
11
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
12
The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. (21757492)
2011
13
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). (21182645)
2010
14
Diagnostic usefulness of a nested polymerase chain reaction assay for detecting Sarcoptes scabiei DNA in skin scrapings from clinically suspected scabies. (20560958)
2010
15
Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. (20177574)
2009
16
Variable response of crusted scabies to oral ivermectin: report on eight Egyptian patients. (19309428)
2009
17
Alcohol-based hand rub and nosocomial scabies. (18690789)
2008
18
A scabies outbreak in a further education college in Gloucestershire. (16948878)
2007
19
Interventions for treating scabies. (17636630)
2007
20
Recommendations for the treatment of scabies infestations in Israel. (16599057)
2006
21
Treatment of steroid-resistant nodular scabies with topical pimecrolimus. (16021143)
2005
22
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. (15872307)
2005
23
Crossreacting IgG antibodies against fox mite antigens in human scabies. (15650895)
2005
24
Biotransformation of the Streptomyces scabies phytotoxin thaxtomin A by the fungus Aspergillus niger. (15052314)
2004
25
Scabies: new future for a neglected disease. (15504541)
2004
26
Pyoderma and scabies: a benign association? (12734437)
2003
27
Scabies: a differential diagnosis of pruritus following subarachnoid opioid administration. (14616629)
2003
28
Current treatments for scabies. (12667233)
2003
29
Seasonality trends of scabies in a young adult population: a 20-year follow-up. (12890210)
2003
30
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
31
Crusted (Norwegian) scabies. (11932093)
2002
32
Use of ivermectin, given orally, to control scabies in homes for the elderly mentally ill. (12166302)
2002
33
Factors supporting sustainability of a community-based scabies control program. (12423434)
2002
34
Parasitic skin infestations II, scabies, pediculosis, spider bites: unapproved treatments. (12490354)
2002
35
Dealing with scabies. (12216245)
2001
36
Outcome of an interventional program for scabies in an Indigenous community. (11700814)
2001
37
Scabies presenting as a blistering eruption. (11710447)
2001
38
Stopping the itch of scabies and lice. (10983095)
2000
39
The use of ivermectin in controlling an outbreak of scabies in a prison. (10971323)
2000
40
Scabies in some workers living in crowded area, Jeddah, Saudi Arabia. (10786043)
2000
41
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. (10617527)
2000
42
Case report: teledermatology and epiluminescence microscopy for the diagnosis of scabies. (10916694)
2000
43
Treatment of human scabies with oral ivermectin. (10564922)
1999
44
Before using ivermectin therapy for scabies. (10632951)
1999
45
Pathogenicity of Streptomyces scabies Mutants Altered in Thaxtomin A Production. (18944924)
1998
46
Crusted (Norwegian) scabies as a pre-diagnostic indicator for HTLV-1 infection. (8236396)
1993
47
Coexistence of unusual scabies and pneumocystosis in a patient without any underlying disease. (6376579)
1984
48
Norwegian scabies: occurrence in a patient undergoing immunosuppression. (822784)
1976
49
Norwegian scabies and lymphatic leukaemia. (6025578)
1967
50
Norwegian scabies (crusted scabies). (13954071)
1963

Variations for Scabies

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Expression for genes affiliated with Scabies

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Expression patterns in normal tissues for genes affiliated with Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for genes affiliated with Scabies

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Compounds for genes affiliated with Scabies

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Compounds related to Scabies according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1antistasin4410.2F2, CFP
2benzidine4410.1KITLG, GSTM1
3protamine sulfate4410.1KITLG, F2
4pbhp4410.1CSF3, KITLG
5unicap4410.1CCL11, IGHE
6daniplestim4410.1CSF3, KITLG
7carboxymethylcellulose4410.0CSF3, KITLG
8sodium cromoglycate4410.0IGHE, CCL11
9mafosfamide4410.0KITLG, CSF3
104-hydroperoxycyclophosphamide4410.0CSF3, KITLG
11cetirizine44 28 24 1113.0CCL11, IGHE
12pixy3214410.0KITLG, CSF3
13clarithromycin44 1111.0CCL11, F2
14amifostine44 1110.9CSF3, KITLG
15ketotifen44 1110.9CCL11, IGHE
16filgrastim44 1110.9KITLG, CSF3
17hydroxyethyl starch449.9CSF3, F2
18busulfan44 50 1111.8CSF3, GSTM1
19penicillin449.8F2, IGHE
20anti-histamine449.8KITLG, CCL11, IGHE
21budesonide44 50 1111.8IGHE, CCL11, KITLG
22salbutamol44 50 28 24 1113.8CCL11, KITLG, IGHE
23pgd2449.8IGHE, KITLG, CCL11
24sulfamethoxazole50 44 1111.7GSTM1, IGHE
25styrene oxide449.7GSTM1, CYP20A1
26montelukast44 50 28 1112.7IGHE, CCL11
27carboplatin44 50 1111.7KITLG, GSTM1, CSF3
28aspirin44 50 28 2412.6CCL11, F2, KITLG
29hydroxyurea44 50 1111.6CSF3, F2, KITLG
30styrene449.6GSTM1, CYP20A1
31zidovudine44 50 1111.6CSF3, NT5C, KITLG
32cytarabine44 50 1111.6KITLG, CSF3, NT5C
335fluorouracil449.4CSF3, GSTM1, KITLG
34hydrocarbons449.3CYP20A1, GSTM1
35thymidine44 2410.2KITLG, NT5C, CCL11, CSF3
36lactate449.2KITLG, F2, IGHE, GSTM1
37rantes449.2CSF3, KITLG, CCL11
38creatinine449.2IGHE, KITLG, F2, GSTM1
39cyclophosphamide44 50 1111.2IGHE, CSF3, GSTM1, KITLG
40epinephrine44 24 1111.1F2, IGHE, CSF3, KITLG
41heparin44 28 24 1112.1CFP, IGHE, F2, CCL11, KITLG
42cycloheximide449.1IGHE, DST, CSF3, KITLG
43histamine44 28 2410.9CCL11, IGHE, CYP20A1, KITLG
44prednisolone44 28 1110.9IGHE, KITLG, GSTM1, CSF3, CCL11
45dexamethasone44 50 28 1111.9IGHE, KITLG, CCL11, CSF3
46cyclosporin a44 28 6110.8KITLG, CSF3, CCL11, IGHE, F2
47methotrexate50 44 1110.8KITLG, GSTM1, CSF3, F2, IGHE
48testosterone44 61 24 1111.7IGHE, GSTM1, KITLG, CYP20A1
49superoxide44 249.7KITLG, CSF3, CCL11, CFP, CYP20A1
50vegf448.5IGHE, CCL11, KITLG, CSF3

GO Terms for genes affiliated with Scabies

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Cellular components related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6IGHE, CFP, CCL11, KITLG, F2
2extracellular spaceGO:0056158.3KITLG, CSF3, CCL11, CFP, F2

Biological processes related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.7DST, F2
2positive regulation of actin filament polymerizationGO:0308389.6CSF3, CCL11
3positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.2CSF3, F2
4immune responseGO:0069558.9CSF3, CCL11, CFP, IGHE
5innate immune responseGO:0450878.7IGHE, CFP, KITLG, CD300E

Molecular functions related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2KITLG, CSF3, F2

Products for genes affiliated with Scabies

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Sources for Scabies

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25ICD10
26ICD10 via Orphanet
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29KEGG
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