MCID: SCB001
MIFTS: 45

Scabies malady

Infectious category

Summaries for Scabies

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can also spread scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards: Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to norwegian scabies and bullous pemphigoid. An important gene associated with Scabies is CFP (complement factor properdin), and among its related pathways is Synthesis of PE. The drugs ivermectin and lindane and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder.

Disease Ontology:8 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC:3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia:64 Scabies (from Latin: scabere, \"to scratch\"), also known colloquially as the seven-year itch, is a... more...

Aliases & Classifications for Scabies

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

scabies 8 10 34 61
infestation by sarcoptes scabiei var hominis 8
infestation by sarcoptes scabiei 8
sarcoptic itch 8


External Ids:

Disease Ontology8 DOID:8295
ICD9CM27 133.0
MeSH35 D012532
NCIt40 C34998
ICD1025 B86

Related Diseases for Scabies

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Scabies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1norwegian scabies31.4NT5C
2bullous pemphigoid30.4DST
3urticaria30.2IGHE
4atopy30.0IGHE, CCL11
5atopic dermatitis30.0CCL11, IGHE, KITLG
6n syndrome10.4
7acquired immunodeficiency syndrome10.3
8adult lymphoma10.2
9granuloma annulare10.1
10allergic contact dermatitis10.1
11molluscum contagiosum10.1
12hailey-hailey disease10.1
13systemic lupus erythematosus10.1
14adult t-cell leukemia10.1
15lichen planus10.1
16chickenpox10.1
17urticaria pigmentosa10.1
18arthritis10.1
19t-cell leukemia10.1
20mastocytosis10.1
21leukemia/lymphoma, t-cell10.1
22bacteremia10.1
23sepsis10.1
24strongyloidiasis10.0IGHE
25nephrotic syndrome10.0CCL11
26kimura disease10.0IGHE
27migraine10.0GSTM1
28autoimmune lymphoproliferative syndrome10.0NT5C
29dermatitis10.0IGHE, CCL11
30allergic conjunctivitis10.0IGHE, CCL11
31herpes gestationis10.0DST
32eosinophilic pneumonia10.0CCL11, IGHE
33eosinophilic gastroenteritis10.0CCL11, IGHE
34allergic rhinitis10.0CCL11, IGHE
35pemphigus10.0DST
36food allergy10.0IGHE, CCL11
37vernal keratoconjunctivitis10.0CCL11, IGHE
38psoriasis10.0DST, CCL11
39pemphigus vulgaris10.0CCL11, DST
40deficiency anemia10.0GSTM1, KITLG
41pulmonary eosinophilia10.0IGHE, CCL11
42gamma chain deficiency10.0CFP, KITLG
43malaria10.0GSTM1, CFP, WARS
44hypersensitivity reaction type ii disease10.0CFP, DST, WARS, CCL11
45decubitus ulcer9.9
46balanoposthitis9.9
47bloom syndrome9.9
48epidermolysis bullosa simplex9.9
49pneumocystosis9.9
50occupational dermatitis9.9

Graphical network of the top 20 diseases related to Scabies:



Diseases related to scabies

Clinical Features for Scabies

Drugs & Therapeutics for Scabies

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Scabies

Drug clinical trials:

Search ClinicalTrials for Scabies

Search NIH Clinical Center for Scabies

Search CenterWatch for Scabies

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Scabies

Anatomical Context for Scabies

Animal Models for Scabies or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Scabies

Sources:
51PubMed
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Articles related to Scabies:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Norwegian crusted scabies: an unusual case presentation. (24370484)
2014
2
Additional techniques for diagnosing scabies. (23668442)
2013
3
Comparison of oral ivermectin vs. lindane lotion 1% for the treatment of scabies. (23772999)
2013
4
Expedited partner therapy for scabies: legal and ethical considerations. (24124808)
2013
5
Scabies: a suitable case for a global control initiative. (23302759)
2013
6
Intense nocturnal itching should raise suspicion of scabies. (23808128)
2013
7
Epidemiology of scabies prevalence in the U.K. from general practice records. (21574970)
2011
8
Detection of scabies: A systematic review of diagnostic methods. (23205026)
2011
9
Diagnostic usefulness of a nested polymerase chain reaction assay for detecting Sarcoptes scabiei DNA in skin scrapings from clinically suspected scabies. (20560958)
2010
10
Community management of endemic scabies in remote aboriginal communities of northern Australia: low treatment uptake and high ongoing acquisition. (19478832)
2009
11
Scabies with clinical features and positive darier sign mimicking mastocytosis. (19706114)
2009
12
A case report of crusted scabies with methicillin-resistant Staphylococcus aureus bacteremia. (19895437)
2009
13
Skin disorders, including pyoderma, scabies, and tinea infections. (19962029)
2009
14
High burden of impetigo and scabies in a tropical country. (19547749)
2009
15
Generalized pruritus after a beach vacation. Diagnosis: scabies. (18646583)
2008
16
Streptomyces scabies 87-22 possesses a functional tomatinase. (18835993)
2008
17
Treatment of scabies infestations. (18814689)
2008
18
Persistent eosinophilia as a presenting sign of scabies in patients with disorders of keratinization. (17515528)
2007
19
Recommendations for the treatment of scabies infestations in Israel. (16599057)
2006
20
Pimecrolimus related crusted scabies in an infant. (16780486)
2006
21
Can the scabies mite be tamed? (16957430)
2006
22
Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin. (15682247)
2005
23
Scabies, pediculosis, bedbugs, and stinkbugs: uncommon presentations. (16325062)
2005
24
What's eating you? Canine scabies. (12953932)
2003
25
A comparative study between 10 per cent sulfur ointment and 0.3 per cent gamma benzene hexachloride gel in the treatment of scabies in children. (14700144)
2003
26
Ivermectin for scabies. (12887676)
2003
27
Bullous scabies in an adult. (12558642)
2003
28
Infantile scabies or Langerhans cell histiocytosis? (12461795)
2003
29
Crusted (Norwegian) scabies. (11932093)
2002
30
Scabies and pediculosis pubis: an update of treatment regimens and general review. (12353201)
2002
31
Treatment of 18 children with scabies or cutaneous larva migrans using ivermectin. (12139665)
2002
32
Ivermectin is better than benzyl benzoate for childhood scabies in developing countries. (12174005)
2002
33
Atypical crusted scabies in an Iranian man. (12546772)
2002
34
Scabies in free-ranging mountain gorillas (Gorilla beringei beringei) in Bwindi Impenetrable National Park, Uganda. (11817857)
2002
35
Scabies presenting as a blistering eruption. (11710447)
2001
36
Scabies and lice: review of the clinical features and management principles. (11917782)
2001
37
Crusted (Norwegian) scabies in leprosy. (11326599)
2001
38
Stopping the itch of scabies and lice. (10983095)
2000
39
Scratching the itch: management of scabies in A&E. (11760327)
2000
40
Perceptions of the incidence of scabies and efficacy of treatment in U.K. hospitals. (11122057)
2000
41
Crusted (Norwegian) scabies in a patient with dystrophic epidermolysis bullosa. (10583180)
1999
42
Norwegian scabies in a patient with acquired immunodeficiency syndrome. (9812044)
1998
43
Sepsis associated with Norwegian scabies in patients with acquired immunodeficiency syndrome. (1526178)
1992
44
Norwegian scabies in a patient with AIDS. (1571423)
1992
45
Crusted (Norwegian) scabies. (1718155)
1991
46
Crusted (Norwegian) scabies: treatment of nail involvement. (2956293)
1987
47
Norwegian scabies in acquired immunodeficiency syndrome: report of a case resulting in death from associated sepsis. (3819082)
1987
48
Epidemic Norwegian scabies. (134674)
1976
49
Norwegian scabies. (1139749)
1975
50
Norwegian scabies. (13353984)
1956

Genetic Variations for Scabies

Expression for genes affiliated with Scabies

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for genes affiliated with Scabies

Sources:
54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Scabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ETNK1, PHOSPHO1

Compounds for genes affiliated with Scabies

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Scabies according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1unicap4510.2CCL11, IGHE
2sodium cromoglycate4510.2IGHE, CCL11
3cetirizine45 29 11 2413.1CCL11, IGHE
4anti-histamine4510.1KITLG, IGHE, CCL11
5budesonide45 50 1112.1KITLG, IGHE, CCL11
6salbutamol45 50 29 11 2414.1CCL11, IGHE, KITLG
7pgd24510.0KITLG, IGHE, CCL11
8ketotifen45 1111.0IGHE, CCL11
9O-Phosphoethanolamine11 2411.0ETNK1, PHOSPHO1
10styrene oxide4510.0CYP20A1, GSTM1
11styrene459.9CYP20A1, GSTM1
12prednisolone45 29 1111.9CCL11, IGHE, KITLG, GSTM1
13benzidine459.7GSTM1, KITLG
14ethanolamine45 11 2411.7ETNK1, PHOSPHO1
15histamine45 29 2411.3CCL11, IGHE, CYP20A1, KITLG

GO Terms for genes affiliated with Scabies

Sources:
16Gene Ontology
See all sources

Cellular components related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1GSTM1, EEF1E1, ETNK1, DST, NT5C, ITCH

Biological processes related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylethanolamine biosynthetic processGO:0066469.5ETNK1, PHOSPHO1
2innate immune responseGO:0450879.3CFP, KITLG, CD300E, IGHE, ITCH

Products for genes affiliated with Scabies

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Scabies

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet