Aliases & Classifications for Scabies

MalaCards integrated aliases for Scabies:

Name: Scabies 12 72 40 69 3 41 14
Infestation by Sarcoptes Scabiei Var Hominis 12
Infestation by Sarcoptes Scabiei 12
Sarcoptic Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8295
ICD10 32 B86
ICD9CM 34 133.0
MeSH 41 D012532
NCIt 46 C34998
UMLS 69 C0036262

Summaries for Scabies

MedlinePlus : 40 Scabies is an itchy skin condition caused by the microscopic mite Sarcoptes scabei. It is common all over the world, and can affect anyone. Scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. Hospitals, child-care centers, and nursing homes are examples. Scabies can easily infect sex partners and other household members. Sharing clothes, towels, and bedding can sometimes spread scabies. This can happen much more easily when the infested person has crusted scabies. You cannot get scabies from a pet. Pets get a different mite infection called mange. Symptoms are Pimple-like irritations or a rash Intense itching, especially at night Sores caused by scratching Your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. Several lotions are available to treat scabies. The infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. Treatment is also recommended for household members and sexual partners. Centers for Disease Control and Prevention

MalaCards based summary : Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to allergic contact dermatitis and psoriasis, and has symptoms including pruritus, fever and exanthema. An important gene associated with Scabies is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Disease Ontology : 12 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC : 3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia : 72 Scabies, also known as the seven-year itch, is a contagious skin infestation by the mite Sarcoptes... more...

Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 29.9 CXCL8 IL10
2 psoriasis 29.8 CXCL8 IL10 IL1A
3 tungiasis 29.8 CXCL8 IL10
4 arthritis 29.8 CXCL8 IL10 IL1A
5 contact dermatitis 29.7 CXCL8 IL10 IL1A
6 endocarditis 29.5 CXCL8 IL10
7 dermatitis, atopic 29.4 CCL11 CXCL8 IL10
8 toxic shock syndrome 29.4 CXCL8 IL10
9 allergic hypersensitivity disease 29.3 CCL11 IL10 KITLG
10 asthma 28.1 CCL11 CXCL8 IL10 IL1A KITLG
11 norwegian scabies 12.6
12 pyoderma 11.3
13 chronic graft versus host disease 10.4 IL10 IL1A
14 multidrug-resistant tuberculosis 10.3 IL10 IL1A
15 post-transplant lymphoproliferative disease 10.3 IL10 IL1A
16 extrapulmonary tuberculosis 10.3 IL10 IL1A
17 idiopathic neutropenia 10.3 IL10 IL1A
18 leukoregulin 10.3 CXCL8 IL1A
19 sebaceous gland disease 10.3 CXCL8 IL1A
20 cryptosporidiosis 10.3 CCL11 IL1A
21 acute transverse myelitis 10.3 CXCL8 IL10
22 pouchitis 10.3 CXCL8 IL10
23 necatoriasis 10.3 CXCL8 IL10
24 oral candidiasis 10.3 CXCL8 IL1A
25 funisitis 10.3 CXCL8 IL10
26 trichuriasis 10.3 CXCL8 IL10
27 clonorchiasis 10.2 CXCL8 IL10
28 bullous keratopathy 10.2 CXCL8 IL1A
29 retinitis pigmentosa 44 10.2 CXCL8 IL10
30 transverse myelitis 10.2 CXCL8 IL10
31 mycetoma 10.2 CXCL8 IL10
32 aseptic meningitis 10.2 CXCL8 IL10
33 primary peritoneal carcinoma 10.2 CXCL8 IL10
34 cytomegalovirus infection 10.2 CXCL8 IL10
35 acute pyelonephritis 10.2 CXCL8 IL10
36 viral encephalitis 10.2 CXCL8 IL10
37 tonsillitis 10.2 CXCL8 IL1A
38 prostatitis 10.2 CXCL8 IL10
39 leptospirosis 10.2 CXCL8 IL10
40 brucellosis 10.2 CXCL8 IL10
41 pyelonephritis 10.2 CXCL8 IL10
42 silicosis 10.2 CXCL8 IL1A
43 peptic ulcer disease 10.2 CXCL8 IL10
44 appendicitis 10.2 CXCL8 IL10
45 dengue hemorrhagic fever 10.2 CXCL8 IL10
46 chorioamnionitis 10.2 CXCL8 IL1A
47 shigellosis 10.2 CXCL8 IL10
48 extrinsic allergic alveolitis 10.2 CXCL8 IL10
49 bronchiolitis obliterans 10.2 CXCL8 IL10
50 papillary conjunctivitis 10.2 CCL11 CXCL8

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:



Diseases related to Scabies

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:


pruritus, fever, exanthema

Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 70288-86-7 46936176 6474909
2
Permethrin Approved, Investigational Phase 4,Phase 3,Phase 2 52645-53-1 40326
3
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2
5 Antiparasitic Agents Phase 4,Phase 3,Phase 2
6
Metronidazole Approved Phase 3 443-48-1 4173
7
Malathion Approved, Investigational Phase 3 121-75-5 4004
8 Antiprotozoal Agents Phase 3
9 Cholinergic Agents Phase 3
10 Cholinesterase Inhibitors Phase 3
11 Neurotransmitter Agents Phase 3
12 Dermatologic Agents Phase 3
13 Emollients Phase 3
14
Albendazole Approved, Vet_approved 54965-21-8 2082
15
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
16 Vaccines
17 Anthelmintics
18 Antimitotic Agents
19 Liver Extracts
20 Lipoxygenase Inhibitors

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
2 A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies Completed NCT02572986 Phase 3 Permethrin
3 Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies. Completed NCT02978508 Phase 3 Permethrin Cream, 5%;Elimite
4 Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Completed NCT02236403 Phase 3 Ivermectin 0.1% Metronidazole 1%
5 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Recruiting NCT02485704 Phase 3 spinosad topical suspension, 0.9%
6 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Recruiting NCT02485717 Phase 3 spinosad topical suspension, 0.9%
7 Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children Recruiting NCT02407782 Phase 3 Ivermectin;Permethrin
8 Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies Active, not recruiting NCT03178942 Phase 3 Permethrin;Elimite 5% Cream
9 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Active, not recruiting NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
10 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
11 A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of Permethrin Foam, 5% and Permethrin Foam, 4% for the Treatment of Scabies Completed NCT02094716 Phase 2 Permethrin Foam 4%;Permethrin Foam 5%;Vehicle Foam
12 Comparison of the Efficacy and Safety of Ivermectin to Permethrin Completed NCT00262418 Phase 2 Administration of ivermectin or permethrin
13 Veron Scabies Education and Eradication Program Completed NCT00604084 Ivermectin;Permethrin 5% lotion
14 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
15 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
16 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
17 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
18 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
19 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
20 PCR Assay for Diagnosis of Sarcoptes Scabiei Active, not recruiting NCT02254564

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: scabies

Genetic Tests for Scabies

Anatomical Context for Scabies

MalaCards organs/tissues related to Scabies:

38
Skin, T Cells, Testes, Liver, Kidney, Brain, Neutrophil

Publications for Scabies

Articles related to Scabies:

(show top 50) (show all 746)
# Title Authors Year
1
Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials. ( 29241784 )
2018
2
Management of a family outbreak of scabies with high risk of spread to other community and hospital facilities. ( 29397231 )
2018
3
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
4
Increased risk of psoriasis following scabies infection: A nationwide population-based matched-cohort study. ( 29356052 )
2018
5
Increased risk of pernicious anemia following scabies: a nationwide population-based matched-cohort study. ( 29066901 )
2017
6
Scabies-An ancient itch that is still rampant today. ( 28948630 )
2017
7
Contribution of the I^-glucosidase BglC to the onset of the pathogenic lifestyle of Streptomyces scabies. ( 29077242 )
2017
8
The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial. ( 28722612 )
2017
9
Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections. ( 28671945 )
2017
10
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
11
Clinical Inquiry: What is the most effective treatment for scabies? ( 28783773 )
2017
12
Comparative Efficacy of Topical Pertmehrin, Crotamiton and Sulfur Ointment in Treatment of Scabies. ( 29018829 )
2017
13
An endemic of scabies in Kahuta, Azad Kashmir. The study shows a lack of awareness of scabies; mass treatment is needed. ( 28924288 )
2017
14
Mitochondrial genome sequencing reveals potential origins of the scabies mite Sarcoptes scabiei infesting two iconic Australian marsupials. ( 29183283 )
2017
15
The association between scabies and myasthenia gravis: A nationwide population-based cohort study. ( 28890037 )
2017
16
Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant. ( 29186253 )
2017
17
Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report. ( 28851633 )
2017
18
The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. ( 28941561 )
2017
19
Scabies Associated with Granulomatous Dermatitis. ( 28868002 )
2017
20
Scratching the itch: is scabies a truly neglected disease? ( 28941562 )
2017
21
Leukocytoclastic vasculitis associated with crusted scabies. ( 29199154 )
2017
22
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2017
23
Biosynthesis and evolution of coronafacoyl phytotoxin production in the common scab pathogen Streptomyces scabies. ( 28754703 )
2017
24
What's eating you? scabies in the developing world. ( 29232427 )
2017
25
Crusted Scabies. ( 28767353 )
2017
26
Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin Positive S. aureus Mimic Hyper IgE Syndrome in an Infant. ( 28938255 )
2017
27
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. ( 28771469 )
2017
28
Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. ( 28062820 )
2017
29
Characterization of Sarcoptes scabiei Tropomyosin and Paramyosin: Immunoreactive Allergens in Scabies. ( 28722633 )
2017
30
Expression and characterisation of a Sarcoptes scabiei protein tyrosine kinase as a potential antigen for scabies diagnosis. ( 28852108 )
2017
31
Scabies and mortality. ( 29173877 )
2017
32
Patient Perspectives: What is Scabies? ( 28054720 )
2017
33
Scabies outbreak among healthcare workers in a German acute care hospital. ( 28989526 )
2017
34
Clinical diagnosis of crusted scabies: Reverse focal pattern of plantar keratoderma. ( 29243244 )
2017
35
Scabies in the age of increasing drug resistance. ( 29190303 )
2017
36
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. ( 29279260 )
2017
37
Scabies masquerading as bullous pemphigoid: scabies surrepticius. ( 28883737 )
2017
38
Ignoring the "Itch": The Global Health Problem of Scabies. ( 29016295 )
2017
39
Scabies in babies. ( 28833468 )
2017
40
Case Report: Bullous Scabies in Two Children below 10 Years. ( 29016306 )
2017
41
Scabies. ( 28879092 )
2017
42
Membranous glomerulonephritis overlapping with scabies. ( 27512313 )
2016
43
Videodermoscopy compared to reflectance confocal microscopy for the diagnosis of scabies. ( 27168425 )
2016
44
Efficacy, acceptability and cost effectiveness of four therapeutic agents for treatment of scabies. ( 27027929 )
2016
45
A whole genome analysis reveals the presence of a plant PR1 sequence in the potato pathogen Streptomyces scabies and other Streptomyces species. ( 27530704 )
2016
46
S1 guidelines on the diagnosis and treatment of scabies - short version. ( 27879074 )
2016
47
Reporting in the clinical trials evaluating scabies treatments. ( 27614482 )
2016
48
Safety of Topical Medications for Scabies and Lice in Pregnancy. ( 27904173 )
2016
49
Impetigo and scabies - Disease burden and modern treatment strategies. ( 27180311 )
2016
50
Can immunosuppressive therapy facilitate the diagnosis and affect the clinical signs of canine scabies? A retrospective study of 79 cases. ( 27109747 )
2016

Variations for Scabies

Expression for Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CCL11 CXCL8 IL10 IL1A KITLG MBL2
2
Show member pathways
13.48 CCL11 CXCL8 IL10 IL1A KITLG
3
Show member pathways
13.28 CCL11 CXCL8 IL10 IL1A KITLG
4
Show member pathways
13.16 CCL11 CXCL8 IL10 IL1A KITLG
5
Show member pathways
13.04 CCL11 CXCL8 IL10 IL1A KITLG
6
Show member pathways
12.97 CCL11 CXCL8 IL10 IL1A KITLG
7
Show member pathways
12.83 CCL11 CXCL8 IL10 IL1A KITLG
8
Show member pathways
12.47 CCL11 CXCL8 IL10 IL1A
9 11.87 CXCL8 IL10 IL1A
10
Show member pathways
11.79 CXCL8 IL10 IL1A
11 11.41 CCL11 IL10
12 11.4 CCL11 CXCL8
13
Show member pathways
11.4 CXCL8 IL1A
14 11.38 CXCL8 IL10 IL1A
15 11.33 IL10 MBL2
16 11.27 CXCL8 IL10
17 11.25 IL1A KITLG
18 11.22 CCL11 IL10
19 11.12 CXCL8 IL10 IL1A
20 11.08 IL10 IL1A
21 10.99 IL10 IL1A
22 10.98 CCL11 CXCL8 IL10 IL1A
23 10.49 CCL11 CXCL8 IL10 IL1A
24 10.46 CCL11 CXCL8 IL10 IL1A KITLG

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL10 IL1A KITLG MBL2
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL10 IL1A KITLG MBL2

Biological processes related to Scabies according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 CCL11 CXCL8 IL10 IL1A
2 positive regulation of angiogenesis GO:0045766 9.54 CCL11 CXCL8 IL1A
3 positive regulation of endothelial cell proliferation GO:0001938 9.49 CCL11 IL10
4 neutrophil chemotaxis GO:0030593 9.48 CCL11 CXCL8
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.46 IL1A KITLG
6 inflammatory response GO:0006954 9.46 CCL11 CXCL8 IL10 IL1A
7 positive regulation of cytokine secretion GO:0050715 9.43 IL10 IL1A
8 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 MBL2
9 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
10 regulation of receptor activity GO:0010469 9.02 CCL11 CXCL8 IL10 IL1A KITLG
11 ectopic germ cell programmed cell death GO:0035234 8.96 IL1A KITLG

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL10 IL1A KITLG
2 chemokine activity GO:0008009 8.96 CCL11 CXCL8

Sources for Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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