Aliases & Classifications for Scabies

Aliases & Descriptions for Scabies:

Name: Scabies 12 41 3 42 14 69
Infestation by Sarcoptes Scabiei Var Hominis 12
Infestation by Sarcoptes Scabiei 12
Sarcoptic Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8295
ICD10 33 B86
ICD9CM 35 133.0
MeSH 42 D012532
NCIt 47 C34998
UMLS 69 C0036262

Summaries for Scabies

MedlinePlus : 41 scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can sometimes spread scabies. this can happen much more easily when the infested person has crusted scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards based summary : Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to burns and norwegian scabies, and has symptoms including exanthema, fever and pruritus. An important gene associated with Scabies is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells.

CDC : 3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Disease Ontology : 12 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

Wikipedia : 71 Scabies, previously known as the seven-year itch, is a contagious skin infestation by the mite Sarcoptes... more...

Related Diseases for Scabies

Diseases related to Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
id Related Disease Score Top Affiliating Genes
1 burns 29.4 CXCL8 IL10
2 norwegian scabies 12.4
3 pyoderma 11.2
4 renovascular hypertension 10.2 CXCL8 IL1A
5 stomach carcinoma in situ 10.2 CXCL8 IL1A
6 sclerosing cholangitis 10.2 CXCL8 IL1A
7 contact lens corneal edema 10.2 CXCL8 IL1A
8 drug psychosis 10.2 CCL11 IL1A
9 psychotic disorder 10.2 CCL11 CXCL8
10 retinal vascular disease 10.2 CCL11 CXCL8
11 ciliary discoordination, due to random ciliary orientation 10.2 IL10 IL1A
12 conidiobolomycosis 10.2 CXCL8 IL10
13 inflammatory bowel disease 20 10.2 CXCL8 IL10
14 sarcomatoid transitional cell carcinoma 10.2 IL10 IL1A
15 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL10
16 coronary arterial fistulas 10.2 CXCL8 IL10
17 mental retardation hypotonia skin hyperpigmentation 10.2 CFP IL1A
18 childhood electroclinical syndrome 10.2 CXCL8 IL10
19 middle lobe syndrome 10.2 CXCL8 IL10
20 skin conditions 10.2 CXCL8 IL1A
21 primary ciliary dyskinesia 10.2 IL10 IL1A
22 plantar wart 10.2 CXCL8 IL10
23 hydrophthalmos 10.2 CCL11 CXCL8
24 nasopharyngitis 10.2 CXCL8 IL1A
25 trichomalacia 10.2 CXCL8 IL10
26 senile reticular retinal degeneration 10.2 CXCL8 IL10
27 gastric dilatation 10.2 CXCL8 IL10
28 fallopian tube serous adenocarcinoma 10.1 CXCL8 IL10
29 immunoglobulin g deficiency 10.1 IL10 IL1A
30 erb-duchenne and dejerine-klumpke palsies 10.1 CXCL8 IL10
31 immunodeficiency due to a late component of complement deficiency 10.1 CXCL8 IL10
32 labyrinthitis 10.1 CXCL8 IL10
33 atrophy of prostate 10.1 CXCL8 IL10
34 myiasis 10.1 CXCL8 IL10
35 patellar tendinitis 10.1 CCL11 CXCL8
36 alcoholic hepatitis 10.1 CXCL8 IL10
37 childhood central nervous system mixed germ cell tumor 10.1 CXCL8 IL10
38 chordoid meningioma 10.1 CXCL8 IL10
39 choroiditis 10.1 CXCL8 IL10
40 entropion 10.1 CXCL8 IL10
41 breast apocrine carcinoma in situ 10.1 CXCL8 IL10
42 stenosis of lacrimal sac 10.1 CXCL8 IL1A
43 tracheitis 10.1 CCL11 CXCL8
44 depressed scar 10.1 CXCL8 IL10
45 autosomal recessive type iv ehlers-danlos syndrome 10.0 CXCL8 IL10 IL1A
46 inappropriate adh syndrome 10.0 CXCL8 IL10 IL1A
47 infancy electroclinical syndrome 10.0 CXCL8 IL10 IL1A
48 balkan nephropathy 10.0 CXCL8 IL10
49 classic type lipoma 10.0 CXCL8 IL10 IL1A
50 parasitic protozoa infectious disease 10.0 CXCL8 IL10 IL1A

Comorbidity relations with Scabies via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Ischemic Heart Disease
Protein-Energy Malnutrition Schizophreniform Disorder

Graphical network of the top 20 diseases related to Scabies:



Diseases related to Scabies

Symptoms & Phenotypes for Scabies

UMLS symptoms related to Scabies:


exanthema, fever, pruritus

Drugs & Therapeutics for Scabies

Drugs for Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 4,Phase 3,Phase 2 70288-86-7 6474909 46936176
2
Permethrin Approved, Investigational Phase 4,Phase 3,Phase 2 52645-53-1 40326
3
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2
5 Antiparasitic Agents Phase 4,Phase 3,Phase 2
6
Metronidazole Approved Phase 3 443-48-1 4173
7 Antiprotozoal Agents Phase 3
8 Dermatologic Agents Phase 3
9 Emollients Phase 3
10
Albendazole Approved, Vet_approved 54965-21-8 2082
11 Vaccines
12 Anthelmintics
13 Antimitotic Agents

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4
2 A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies Completed NCT02572986 Phase 3
3 Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Completed NCT02236403 Phase 3
4 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Recruiting NCT02485704 Phase 3
5 Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies Recruiting NCT02485717 Phase 3
6 Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children Recruiting NCT02407782 Phase 3
7 Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies. Recruiting NCT02978508 Phase 3
8 Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies Active, not recruiting NCT03178942 Phase 3
9 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3
10 A Dose Ranging Vehicle Controlled Study to Determine the Safety and Efficacy of PF-045 and PF-055 for the Treatment of Scabies Completed NCT02094716 Phase 2
11 Comparison of the Efficacy and Safety of Ivermectin to Permethrin Completed NCT00262418 Phase 2
12 Veron Scabies Education and Eradication Program Completed NCT00604084
13 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
14 Streptococcal Infections in Fiji - Prevalence of Group A Streptococcal Pyoderma and Scabies in Infants in Fiji Completed NCT00436891
15 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
16 Incidence of Group A Strep Pharyngitis in School Children in Fiji Completed NCT00284882
17 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753
18 PCR Assay for Diagnosis of Sarcoptes Scabiei Recruiting NCT02254564
19 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Not yet recruiting NCT03177993

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: scabies

Genetic Tests for Scabies

Anatomical Context for Scabies

MalaCards organs/tissues related to Scabies:

39
Skin, Breast, T Cells, Testes, Kidney, Brain, Neutrophil

Publications for Scabies

Articles related to Scabies:

(show top 50) (show all 705)
id Title Authors Year
1
Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. ( 28062820 )
2017
2
Patient Perspectives: What is Scabies? ( 28054720 )
2017
3
Crusted scabies in a liver transplant patient mimicking rupioid psoriasis. ( 27297820 )
2016
4
The Treatment of Scabies. ( 27974144 )
2016
5
The Prevalence of Scabies and Impetigo in the Solomon Islands: A Population-Based Survey. ( 27348119 )
2016
6
Scabies Outbreak in the 14th Century: Clues from Correspondence Between Poets. ( 27288856 )
2016
7
Impetigo and scabies - Disease burden and modern treatment strategies. ( 27180311 )
2016
8
Reporting in the clinical trials evaluating scabies treatments. ( 27614482 )
2016
9
The management of scabies outbreaks in residential care facilities for the elderly in England: a review of current health protection guidelines. ( 27734781 )
2016
10
Histology Resembling Cutaneous T-Cell Lymphoma in Nodular Scabies: A Case Report. ( 26955156 )
2016
11
Scabies among the French armed forces inA 2015. ( 27394405 )
2016
12
IMAGES IN CLINICAL MEDICINE. Scabies. ( 26981951 )
2016
13
Analysis of IgE binding patterns to house dust mite allergens in scabies-endemic communities: insights for both diseases. ( 26914255 )
2016
14
Nail Scabies: An Unusual Presentation Often Overlooked and Mistreated. ( 27613759 )
2016
15
Production of the Streptomyces scabies coronafacoyl phytotoxins involves a novel biosynthetic pathway with an F420 -dependent oxidoreductase and a short-chain dehydrogenase/reductase. ( 26991928 )
2016
16
Topical phenothrin treatment in a case of crusted scabies with nail involvement. ( 27666132 )
2016
17
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
18
Scabin, a novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies. ( 27002155 )
2016
19
Effect of high-fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies. ( 26918286 )
2016
20
Crusted (Norvegian) scabies. ( 27347483 )
2016
21
Where to look for the scabies mite. ( 27973976 )
2016
22
Retrospective analysis of institutional scabies outbreaks from 1984 to 2013: lessons learned and moving forward. ( 27019288 )
2016
23
Report - Most common body parts infected with scabies in children and its control. ( 27731834 )
2016
24
Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings. ( 27659511 )
2016
25
The effects of climate factors on scabies. A 14-year population-based study in Taiwan. ( 27905271 )
2016
26
Bullous Scabies. ( 27402514 )
2016
27
A whole genome analysis reveals the presence of a plant PR1 sequence in the potato pathogen Streptomyces scabies and other Streptomyces species. ( 27530704 )
2016
28
S1 guidelines on the diagnosis and treatment of scabies - short version. ( 27879074 )
2016
29
Videodermoscopy compared to reflectance confocal microscopy for the diagnosis of scabies. ( 27168425 )
2016
30
Safety of Topical Medications for Scabies and Lice in Pregnancy. ( 27904173 )
2016
31
Crusted Scabies: Presenting as erythroderma in a human immunodeficiency virus-seropositive patient. ( 27190417 )
2016
32
Treatment of scabies, comparing the different medications ( 27770765 )
2016
33
Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model. ( 27732588 )
2016
34
Scabies increased the risk and severity of COPD: a nationwide population-based study. ( 27672322 )
2016
35
Prevalence and drivers of human scabies among children and adolescents living and studying in Cameroonian boarding schools. ( 27430556 )
2016
36
Mass Drug Administration for Scabies Control. ( 27119244 )
2016
37
Control of scabies in endemic areas: Is mass drug administration the solution? ( 27492032 )
2016
38
Can immunosuppressive therapy facilitate the diagnosis and affect the clinical signs of canine scabies? A retrospective study of 79 cases. ( 27109747 )
2016
39
Genomic resources and draft assemblies of the human and porcine varieties of scabies mites, Sarcoptes scabiei var. hominis and var. suis. ( 27250856 )
2016
40
Scabies Among Elderly Korean Patients with Histories of Leprosy. ( 27114302 )
2016
41
Membranous glomerulonephritis overlapping with scabies. ( 27512313 )
2016
42
A new treatment regimen with permethrin in scabies. ( 27982546 )
2016
43
Efficacy, acceptability and cost effectiveness of four therapeutic agents for treatment of scabies. ( 27027929 )
2016
44
Scabies: Advances in Noninvasive Diagnosis. ( 27311065 )
2016
45
Mass Drug Administration for Scabies Control. ( 27119245 )
2016
46
Crusted scabies in a patient with lepromatous leprosy. ( 27183357 )
2016
47
The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity. ( 27250236 )
2016
48
The Importance of Scabies Coinfection in the Treatment Considerations for Impetigo. ( 26599569 )
2016
49
Mass Drug Administration for Scabies Control. ( 27119246 )
2016
50
Bullous Scabies in a 5-Year-Old Child. ( 27671115 )
2016

Variations for Scabies

Expression for Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for Scabies

Pathways related to Scabies according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CCL11 CFP CXCL8 IL10 IL1A KITLG
2
Show member pathways
13.27 CCL11 CXCL8 IL10 IL1A KITLG
3
Show member pathways
13.16 CCL11 CXCL8 IL10 IL1A KITLG
4
Show member pathways
13.02 CCL11 CXCL8 IL10 IL1A KITLG
5
Show member pathways
12.94 CCL11 CXCL8 IL10 IL1A KITLG
6
Show member pathways
12.83 CCL11 CXCL8 IL10 IL1A KITLG
7
Show member pathways
12.45 CCL11 CXCL8 IL10 IL1A
8 11.85 CXCL8 IL10 IL1A
9
Show member pathways
11.71 CXCL8 IL10 IL1A
10 11.4 CCL11 IL10
11 11.39 CCL11 CXCL8
12
Show member pathways
11.38 CXCL8 IL1A
13 11.31 CXCL8 IL10 IL1A
14 11.26 CXCL8 IL10
15 11.24 IL1A KITLG
16 11.22 CCL11 IL10
17 11.05 IL10 IL1A
18 11.02 CXCL8 IL10 IL1A
19 10.98 CCL11 CXCL8 IL10 IL1A
20 10.97 IL10 IL1A
21 10.49 CCL11 CXCL8 IL10 IL1A

GO Terms for Scabies

Cellular components related to Scabies according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CFP CXCL8 IL10 IL1A KITLG
2 extracellular space GO:0005615 9.1 CCL11 CFP CXCL8 IL10 IL1A KITLG

Biological processes related to Scabies according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 CXCL8 IL10 IL1A
2 chemokine-mediated signaling pathway GO:0070098 9.49 CCL11 CXCL8
3 positive regulation of endothelial cell proliferation GO:0001938 9.46 CCL11 IL10
4 inflammatory response GO:0006954 9.46 CCL11 CXCL8 IL10 IL1A
5 neutrophil chemotaxis GO:0030593 9.43 CCL11 CXCL8
6 positive regulation of angiogenesis GO:0045766 9.43 CCL11 CXCL8 IL1A
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.4 IL1A KITLG
8 positive regulation of cytokine secretion GO:0050715 9.37 IL10 IL1A
9 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
10 immune response GO:0006955 9.02 CCL11 CFP CXCL8 IL10 IL1A
11 ectopic germ cell programmed cell death GO:0035234 8.96 IL1A KITLG

Molecular functions related to Scabies according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL10 IL1A KITLG
2 chemokine activity GO:0008009 8.96 CCL11 CXCL8

Sources for Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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