MCID: SCB001
MIFTS: 51

Scabies malady

Infectious diseases category

Summaries for Scabies

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can also spread scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards: Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to norwegian scabies and dermatitis. An important gene associated with Scabies is CFP (complement factor properdin), and among its related pathways is Synthesis of PE. The drugs lindane and ivermectin and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells.

Disease Ontology:8 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC:3 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia:63 Scabies (from Latin: scabere, \"to scratch\"), also known colloquially as the seven-year itch, is a... more...

Aliases & Classifications for Scabies

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

scabies 8 10 33 60
infestation by sarcoptes scabiei var hominis 8
infestation by sarcoptes scabiei 8
sarcoptic itch 8


External Ids:

Disease Ontology8 DOID:8295
ICD9CM27 133.0
MeSH34 D012532
NCIt39 C34998
ICD1025 B86

Related Diseases for Scabies

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Scabies:



Diseases related to scabies

Clinical Features for Scabies

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Drugs & Therapeutics for Scabies

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Scabies

Drug clinical trials:

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Search NIH Clinical Center for Scabies

Search CenterWatch for Scabies

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Scabies

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Anatomical Context for Scabies

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32MalaCards
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MalaCards organs/tissues related to Scabies:

32
Skin, Breast, T cells, Testes, Brain, Kidney, Monocytes, Bone marrow, Bone, Colon

Animal Models for Scabies or affiliated genes

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Publications for Scabies

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50PubMed
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Articles related to Scabies:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Scabies in the nursing home, misdiagnosis means costs, and embarrassment: story of a centenarian smitten by scabies! (24359700)
2014
2
Treatment and control of scabies. (23438966)
2013
3
Comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies. (23431958)
2013
4
Dermacase. Can you identify this condition? Scabies. (23946030)
2013
5
Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin. (22211573)
2012
6
Lice and scabies. (23062053)
2012
7
A 35-month prospective study on onset of scabies in a psychiatric hospital: discussion on patient transfer and incubation period. (21950623)
2012
8
The diagnostic accuracy of dermoscopy for scabies. (22577271)
2012
9
Reflectance confocal microscopic features of dermatophytes, scabies, and demodex. (21844478)
2011
10
Transmission of scabies in a newborn nursery. (21515986)
2011
11
Bullous scabies simulating pemphigoid. (21291656)
2011
12
Recurrent bullous scabies. (20642986)
2010
13
Norwegian scabies in a malnourished young adult: a case report. (20539068)
2010
14
Langerhans cell hyperplasia of the skin mimicking Langerhans cell histiocytosis: a report of two cases in children not associated with scabies. (20594147)
2010
15
Prevention, control and treatment of scabies. (21141167)
2010
16
Permethrin and ivermectin for scabies. (20181973)
2010
17
An Adolescent Patient with Scabies Mimicking Gottron Papules. (21173918)
2009
18
Scabies presenting as solitary mastocytoma-like eruption in an infant. (19689539)
2009
19
The economic burden of pediculosis pubis and scabies infections treated on an outpatient basis in the United States: evidence from private insurance claims data, 2001-2005. (19295471)
2009
20
Effect of potato suberin on Streptomyces scabies proteome. (19019004)
2008
21
Caring for a patient with scabies. (19033960)
2008
22
Labour analgesia and scabies. (17459689)
2007
23
Problems in diagnosing scabies, a global disease in human and animal populations. (17428886)
2007
24
Accuracy of standard dermoscopy for diagnosing scabies. (17190621)
2007
25
Efficacy and tolerability of a new synergized pyrethrins thermofobic foam in comparison with benzyl benzoate in the treatment of scabies in convicts: the ISAC study (Studio Della scabbia in ambiente carcerario). (16836502)
2006
26
Crusted scabies (sarcoptic mange) in four cats due to Sarcoptes scabiei infestation. (16950639)
2006
27
Epidemiological study of scabies in different environmental conditions in central poland. (16198600)
2006
28
Efficacy and tolerability of natural synergised pyrethrins in a new thermo labile foam formulation in topical treatment of scabies: a prospective, randomised, investigator-blinded, comparative trial vs. permethrin cream. (12609786)
2003
29
Norwegian scabies in an elderly patient who died after treatment with gammaBHC. (12729329)
2003
30
Mechanisms for a novel immune evasion strategy in the scabies mite sarcoptes scabiei: a multigene family of inactivated serine proteases. (14675192)
2003
31
Ivermectin for the treatment of resistant scabies. (12549961)
2003
32
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
33
Use of ivermectin, given orally, to control scabies in homes for the elderly mentally ill. (12166302)
2002
34
Economic aspects of controlling scabies on an open fattening farm with ivermectin in feed. (11936411)
2002
35
Bullous hematoma of the palm: an unusual complication of scabies in a child with congenital prothrombin deficiency. (12437569)
2002
36
Comment on "Is a single dose of ivermectin sufficient in crusted scabies?". (12358839)
2002
37
Sulfur for scabies outbreaks in orphanages. (12383106)
2002
38
Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. (11603388)
2001
39
Treatment of human scabies with oral ivermectin. (10564922)
1999
40
National guideline for the management of scabies. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). (10616390)
1999
41
Current treatments for scabies and pediculosis. (10751840)
1999
42
Norwegian scabies complicated by fatal brain abscess in a renal transplant patient. (8684551)
1996
43
Crusted ("Norwegian") scabies in a specialist HIV unit: successful use of ivermectin and failure to prevent nosocomial transmission. (8698358)
1996
44
Ivermectin and crusted (Norwegian) scabies. (8538537)
1995
45
Norwegian scabies in an infant with acquired immunodeficiency syndrome. (2480080)
1989
46
Crusted (Norwegian) scabies. Occurrence in a child undergoing a bone marrow transplant. (3541794)
1987
47
Norwegian scabies in homozygous twins. (945778)
1976
48
Letter: Norwegian scabies and monocytic leukemia. (4519013)
1973
49
A case of Norwegian scabies. (4220639)
1965
50
Norwegian scabies. Report of a case. (13712474)
1961

Genetic Variations for Scabies

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Expression for genes affiliated with Scabies

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for genes affiliated with Scabies

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Scabies according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ETNK1, PHOSPHO1

Compounds for genes affiliated with Scabies

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Scabies according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1unicap4410.2CCL11, IGHE
2sodium cromoglycate4410.2IGHE, CCL11
3cetirizine44 28 11 2413.1CCL11, IGHE
4anti-histamine4410.1KITLG, IGHE, CCL11
5budesonide44 49 1112.1KITLG, IGHE, CCL11
6salbutamol44 49 28 11 2414.1CCL11, IGHE, KITLG
7pgd24410.0KITLG, IGHE, CCL11
8ketotifen44 1111.0IGHE, CCL11
9O-Phosphoethanolamine11 2411.0ETNK1, PHOSPHO1
10styrene oxide4410.0CYP20A1, GSTM1
11styrene449.9CYP20A1, GSTM1
12prednisolone44 28 1111.9CCL11, IGHE, KITLG, GSTM1
13benzidine449.7GSTM1, KITLG
14ethanolamine44 11 2411.7ETNK1, PHOSPHO1
15histamine44 28 2411.3CCL11, IGHE, CYP20A1, KITLG

GO Terms for genes affiliated with Scabies

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16Gene Ontology
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Cellular components related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1GSTM1, EEF1E1, ETNK1, DST, NT5C, ITCH

Biological processes related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylethanolamine biosynthetic processGO:0066469.5ETNK1, PHOSPHO1
2innate immune responseGO:0450879.3CFP, KITLG, CD300E, IGHE, ITCH

Products for genes affiliated with Scabies

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Sources for Scabies

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet