MCID: SCB001
MIFTS: 58

Scabies malady

Infectious diseases category
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Summaries for Scabies

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Scabies is an itchy skin condition caused by the microscopic mite sarcoptes scabei. it is common all over the world, and can affect anyone. scabies spreads quickly in crowded conditions where there is frequent skin-to-skin contact between people. hospitals, child-care centers, and nursing homes are examples. scabies can easily infect sex partners and other household members. sharing clothes, towels, and bedding can sometimes spread scabies. this can happen much more easily when the infested person has crusted scabies. you cannot get scabies from a pet. pets get a different mite infection called mange. symptoms are pimple-like irritations or a rash intense itching, especially at night sores caused by scratching your health care provider diagnoses scabies by looking at the skin rash and finding burrows in the skin. several lotions are available to treat scabies. the infected person's clothes, bedding and towels should be washed in hot water and dried in a hot dryer. treatment is also recommended for household members and sexual partners. centers for disease control and prevention

MalaCards: Scabies, also known as infestation by sarcoptes scabiei var hominis, is related to bullous pemphigoid and leukemia. An important gene associated with Scabies is CFP (complement factor properdin), and among its related pathways are Selected targets of GCR alpha and IL4-mediated signaling events. The drugs ivermectin and lindane and the compounds antistasin and benzidine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

CDC:4 Human scabies is caused by an infestation of the skin by the human itch mite (Sarcoptes scabiei var. hominis). The microscopic scabies mite burrows into the upper layer of the skin where it lives and lays its eggs. The most common symptoms of scabies are intense itching and a pimple-like skin rash. The scabies mite usually is spread by direct, prolonged, skin-to-skin contact with a person who has scabies.

Wikipedia:65 Scabies (from Latin: scabere, \"to scratch\"), also known colloquially as the seven-year itch, is a... more...

Aliases & Classifications for Scabies

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8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

scabies 8 10 34 62
infestation by sarcoptes scabiei var hominis 8
infestation by sarcoptes scabiei 8
sarcoptic itch 8


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Disease Ontology8 DOID:8295
ICD9CM27 133.0
MeSH35 D012532
NCIt40 C34998
ICD1025 B86

Related Diseases for Scabies

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17GeneCards, 18GeneDecks
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Diseases related to Scabies via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1bullous pemphigoid30.6DST
2leukemia30.4CSF3, KITLG, GSTM1, CCL11
3urticaria30.4IGHE
4atopic dermatitis30.2CCL11
5mastocytosis30.2KITLG, IGHE
6skin disease29.9CCL11, DST, IGHE
7asthma29.8IGHE, GSTM1, KITLG, CCL11
8norwegian scabies11.0
9dermatitis10.3
10psoriasis10.3
11adult t-cell leukemia10.3
12t-cell leukemia10.3
13langerhans-cell histiocytosis10.3
14acquired immunodeficiency syndrome10.3
15histiocytosis10.3
16pyoderma10.3
17granuloma annulare10.1
18allergic contact dermatitis10.1
19contact dermatitis10.1
20eosinophilia10.1
21epidermolysis bullosa10.1
22impetigo10.1
23blindness10.1
24strongyloidiasis10.1IGHE
25conjunctivitis10.1IGHE
26leukemoid reaction10.1CSF3
27allergic conjunctivitis10.1CCL11, IGHE
28eosinophilic gastroenteritis10.1CCL11, IGHE
29eosinophilic pneumonia10.1CCL11, IGHE
30pulmonary eosinophilia10.1CCL11, IGHE
31allergic rhinitis10.1IGHE, CCL11
32food allergy10.1IGHE, CCL11
33vernal keratoconjunctivitis10.1CCL11, IGHE
34hypereosinophilic syndrome10.1CCL11, IGHE
35otitis media10.1IGHE, CCL11
36bronchitis10.1CCL11, IGHE
37gamma chain deficiency10.1CFP, KITLG
38hypersplenism10.1F2
39sinusitis10.1IGHE, CCL11
40bronchiolitis10.1CCL11, IGHE
41respiratory failure10.1CCL11, IGHE
42malaria10.1CFP, GSTM1
43molluscum contagiosum10.1
44lichen planus10.1
45chickenpox10.1
46hailey-hailey disease10.1
47systemic lupus erythematosus10.1
48urticaria pigmentosa10.1
49arthritis10.1
50filariasis10.1

Graphical network of the top 20 diseases related to Scabies:



Diseases related to scabies

Symptoms for Scabies

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Drugs & Therapeutics for Scabies

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Scabies

Search NIH Clinical Center for Scabies

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Scabies

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Anatomical Context for Scabies

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33MalaCards
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MalaCards organs/tissues related to Scabies:

33
Skin, Breast, T cells, Testes, Kidney, Brain, Colon, Bone, Monocytes, Bone marrow

Animal Models for Scabies or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Scabies:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2KITLG, GSTM1, DST, CFP, IGHE, F2
2MP:00053978.0KITLG, CSF3, CCL11, DST, IGHE, F2
3MP:00053877.8F2, IGHE, CFP, CCL11, CSF3, KITLG

Publications for Scabies

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52PubMed
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Articles related to Scabies:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Norwegian crusted scabies: an unusual case presentation. (24370484)
2014
2
Scabies in the nursing home, misdiagnosis means costs, and embarrassment: story of a centenarian smitten by scabies! (24359700)
2014
3
Treatment and control of scabies. (23438966)
2013
4
Novel insights into an old disease: recent developments in scabies mite biology. (23385639)
2013
5
Ivermectin vs. lindane in the treatment of scabies. (23829057)
2013
6
A novel clinical grading scale to guide the management of crusted scabies. (24069468)
2013
7
Entomodermoscopy in scabies - is it a safe and friendly screening test for scabies in children? (22726288)
2012
8
Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin. (22211573)
2012
9
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
10
Novel scabies mite serpins inhibit the three pathways of the human complement system. (22792350)
2012
11
A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei. (22018936)
2011
12
The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. (21757492)
2011
13
Epidemiology of scabies prevalence in the U.K. from general practice records. (21574970)
2011
14
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). (21182645)
2010
15
Diagnostic usefulness of a nested polymerase chain reaction assay for detecting Sarcoptes scabiei DNA in skin scrapings from clinically suspected scabies. (20560958)
2010
16
Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. (20177574)
2009
17
Variable response of crusted scabies to oral ivermectin: report on eight Egyptian patients. (19309428)
2009
18
Alcohol-based hand rub and nosocomial scabies. (18690789)
2008
19
A scabies outbreak in a further education college in Gloucestershire. (16948878)
2007
20
Interventions for treating scabies. (17636630)
2007
21
Recommendations for the treatment of scabies infestations in Israel. (16599057)
2006
22
Treatment of steroid-resistant nodular scabies with topical pimecrolimus. (16021143)
2005
23
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. (15872307)
2005
24
Crossreacting IgG antibodies against fox mite antigens in human scabies. (15650895)
2005
25
Biotransformation of the Streptomyces scabies phytotoxin thaxtomin A by the fungus Aspergillus niger. (15052314)
2004
26
Scabies: new future for a neglected disease. (15504541)
2004
27
Pyoderma and scabies: a benign association? (12734437)
2003
28
Scabies: a differential diagnosis of pruritus following subarachnoid opioid administration. (14616629)
2003
29
Current treatments for scabies. (12667233)
2003
30
Seasonality trends of scabies in a young adult population: a 20-year follow-up. (12890210)
2003
31
Scabies incognito presenting as urticaria pigmentosa in an infant. (12383096)
2002
32
Crusted (Norwegian) scabies. (11932093)
2002
33
Use of ivermectin, given orally, to control scabies in homes for the elderly mentally ill. (12166302)
2002
34
Factors supporting sustainability of a community-based scabies control program. (12423434)
2002
35
Parasitic skin infestations II, scabies, pediculosis, spider bites: unapproved treatments. (12490354)
2002
36
Dealing with scabies. (12216245)
2001
37
Outcome of an interventional program for scabies in an Indigenous community. (11700814)
2001
38
Scabies presenting as a blistering eruption. (11710447)
2001
39
The use of ivermectin in controlling an outbreak of scabies in a prison. (10971323)
2000
40
Scabies in some workers living in crowded area, Jeddah, Saudi Arabia. (10786043)
2000
41
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. (10617527)
2000
42
Case report: teledermatology and epiluminescence microscopy for the diagnosis of scabies. (10916694)
2000
43
Treatment of human scabies with oral ivermectin. (10564922)
1999
44
Before using ivermectin therapy for scabies. (10632951)
1999
45
Pathogenicity of Streptomyces scabies Mutants Altered in Thaxtomin A Production. (18944924)
1998
46
Crusted (Norwegian) scabies as a pre-diagnostic indicator for HTLV-1 infection. (8236396)
1993
47
Coexistence of unusual scabies and pneumocystosis in a patient without any underlying disease. (6376579)
1984
48
Norwegian scabies: occurrence in a patient undergoing immunosuppression. (822784)
1976
49
Norwegian scabies and lymphatic leukaemia. (6025578)
1967
50
Norwegian scabies (crusted scabies). (13954071)
1963

Variations for Scabies

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Expression for genes affiliated with Scabies

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scabies

Search GEO for disease gene expression data for Scabies.

Pathways for genes affiliated with Scabies

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50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Scabies

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Scabies according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1antistasin4510.2F2, CFP
2benzidine4510.1KITLG, GSTM1
3protamine sulfate4510.1KITLG, F2
4pbhp4510.1CSF3, KITLG
5unicap4510.1CCL11, IGHE
6daniplestim4510.1CSF3, KITLG
7carboxymethylcellulose4510.0CSF3, KITLG
8sodium cromoglycate4510.0IGHE, CCL11
9mafosfamide4510.0KITLG, CSF3
104-hydroperoxycyclophosphamide4510.0CSF3, KITLG
11cetirizine45 29 24 1113.0CCL11, IGHE
12pixy3214510.0KITLG, CSF3
13clarithromycin45 1111.0CCL11, F2
14amifostine45 1110.9CSF3, KITLG
15ketotifen45 1110.9CCL11, IGHE
16filgrastim45 1110.9KITLG, CSF3
17hydroxyethyl starch459.9CSF3, F2
18busulfan45 51 1111.8CSF3, GSTM1
19penicillin459.8F2, IGHE
20anti-histamine459.8KITLG, CCL11, IGHE
21budesonide45 51 1111.8IGHE, CCL11, KITLG
22salbutamol45 51 29 24 1113.8CCL11, KITLG, IGHE
23pgd2459.8IGHE, KITLG, CCL11
24sulfamethoxazole51 45 1111.7GSTM1, IGHE
25styrene oxide459.7GSTM1, CYP20A1
26montelukast45 51 29 1112.7IGHE, CCL11
27carboplatin45 51 1111.7KITLG, GSTM1, CSF3
28aspirin45 51 29 2412.6CCL11, F2, KITLG
29hydroxyurea45 51 1111.6CSF3, F2, KITLG
30styrene459.6GSTM1, CYP20A1
31zidovudine45 51 1111.6CSF3, NT5C, KITLG
32cytarabine45 51 1111.6KITLG, CSF3, NT5C
335fluorouracil459.4CSF3, GSTM1, KITLG
34hydrocarbons459.3CYP20A1, GSTM1
35thymidine45 2410.2KITLG, NT5C, CCL11, CSF3
36lactate459.2KITLG, F2, IGHE, GSTM1
37rantes459.2CSF3, KITLG, CCL11
38creatinine459.2IGHE, KITLG, F2, GSTM1
39cyclophosphamide45 51 1111.2IGHE, CSF3, GSTM1, KITLG
40epinephrine45 24 1111.1F2, IGHE, CSF3, KITLG
41heparin45 29 24 1112.1CFP, IGHE, F2, CCL11, KITLG
42cycloheximide459.1IGHE, DST, CSF3, KITLG
43histamine45 29 2410.9CCL11, IGHE, CYP20A1, KITLG
44prednisolone45 29 1110.9IGHE, KITLG, GSTM1, CSF3, CCL11
45dexamethasone45 51 29 1111.9IGHE, KITLG, CCL11, CSF3
46cyclosporin a45 29 6110.8KITLG, CSF3, CCL11, IGHE, F2
47methotrexate51 45 1110.8KITLG, GSTM1, CSF3, F2, IGHE
48testosterone45 61 24 1111.7IGHE, GSTM1, KITLG, CYP20A1
49superoxide45 249.7KITLG, CSF3, CCL11, CFP, CYP20A1
50vegf458.5IGHE, CCL11, KITLG, CSF3

GO Terms for genes affiliated with Scabies

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16Gene Ontology
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Cellular components related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6IGHE, CFP, CCL11, KITLG, F2
2extracellular spaceGO:0056158.3KITLG, CSF3, CCL11, CFP, F2

Biological processes related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:0096119.7DST, F2
2positive regulation of actin filament polymerizationGO:0308389.6CSF3, CCL11
3positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.2CSF3, F2
4immune responseGO:0069558.9CSF3, CCL11, CFP, IGHE
5innate immune responseGO:0450878.7IGHE, CFP, KITLG, CD300E

Molecular functions related to Scabies according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2KITLG, CSF3, F2

Products for genes affiliated with Scabies

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Sources for Scabies

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet