MCID: SCH014
MIFTS: 72

Schistosomiasis malady

Infectious diseases, Blood diseases categories

Summaries for Schistosomiasis

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8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Schistosomiasis is a disease caused by parasitic worms. although the worms that cause schistosomiasis are not found in the united states, more than 200 million people are infected worldwide. infection occurs through contact with contaminated water. the parasite in its infective stages is called a cercaria. it swims freely in open bodies of water. on contact with humans, the parasite burrows into the skin, matures into another stage (schistosomula), then migrates to the lungs and liver, where it matures into the adult form. the adult worm then migrates to its preferred body part (bladder, rectum, intestines, liver, portal venous system (the veins that carry blood from the intestines to liver, spleen, lungs), depending on its species.  schistosomiasis is common in many tropical and subtropical areas worldwide. it can be treated safely and effectively with praziquantel. last updated: 3/15/2013

MalaCards: Schistosomiasis, also known as schistosoma mansoni infection, is related to urinary schistosomiasis and intestinal schistosomiasis. An important gene associated with Schistosomiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Allograft rejection and Leishmaniasis. The drug praziquantel and the compounds dexamethasone and allergens have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and spleen, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus schistosoma. the symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

CDC:3 Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the Neglected Tropical Diseases (NTDs).

Wikipedia:63 Schistosomiasis /ˌʃistəsɵˈmaɪəsəs/ (also known as bilharzia) is a disease caused by parasitic... more...

Description from OMIM:46 181460

Aliases & Classifications for Schistosomiasis

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42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
schistosomiasis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

schistosomiasis 8 42 10 44 48 46 60
schistosoma mansoni infection 42
schistosomiasis japonica 60
katayama fever 42
blood fluke 42
bilharzia 42


External Ids:

Disease Ontology8 DOID:1395
ICD9CM27 120.8
OMIM46 181460
MESH via Orphanet35 D012552
SNOMED-CT via Orphanet57 10087007, 105661001
ICD10 via Orphanet26 B65.0, B65.2, B65.1 B65.3, B65.8, B65.9, more
UMLS via Orphanet61 C0036323

Related Diseases for Schistosomiasis

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17GeneCards, 18GeneDecks
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Diseases related to Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 277)
idRelated DiseaseScoreTop Affiliating Genes
1urinary schistosomiasis31.6AKR7A2
2intestinal schistosomiasis31.3MRGPRE, MRGPRF
3hepatitis30.8CD40LG
4malaria30.7IFNG, IFNGR1, IL10, TSPAN32
5hypertension30.6PPBP
6filariasis30.5IL5, IL13, IGHE
7hepatitis c30.5IL4, IL10, CD40LG, IFNG
8onchocerciasis30.4EPX, RNASE3, IL5
9skin disease30.4IFNG, STAT6, IGHE, RNASE3, IL13, IL10
10atopic dermatitis30.4IL4, IL13, RNASE3, STAT6
11strongyloidiasis30.3IGHE, IL5
12eosinophilia30.2STAT6, IFNG, IGHE, EPX, RNASE3, IL13
13hepatitis b30.1IFNG
14paragonimiasis30.1IGHE, IL5
15pancreatitis30.1IL10
16asthma30.1IFNG, PPBP, STAT6, IGHE, EPX, RNASE3
17tuberculosis30.1IL4, IL10, EPX, IFNGR1, IFNG
18esophagitis29.9IL5, IL13
19toxocariasis29.9IGHE, RNASE3
20glomerulonephritis29.9CD40LG
21toxoplasmosis29.9CD40LG
22liver cirrhosis29.9SERPINF2
23dermatitis29.7IFNG, IGHE, IL13, IL5, IL4
24leishmaniasis29.7IFNG, IFNGR1, IL13, IL10, IL5, IL4
25eosinophilic pneumonia29.7IL5, IL13, RNASE3, IGHE
26pneumonia29.7EPX, IL13, IL10, IL5
27nephrotic syndrome29.7PPBP, IL13, SERPINF2
28pulmonary tuberculosis29.7IL4, IL10, IFNGR1, IFNG
29paracoccidioidomycosis29.7IL10
30disseminated intravascular coagulation29.7PPBP, SERPINF2, TSPAN32
31deficiency anemia29.7EPX, PPBP
32pulmonary fibrosis29.7IL13
33vascular disease29.7IL10, SERPINF2
34thrombocytopenia29.7CD40LG, PPBP
35breast cancer29.7IFNGR1, FABP12, PPBP, STAT6, LGMN, TSPAN32
36colorectal cancer29.7LGMN
37fascioliasis10.5
38schistosoma mansoni infection, susceptibility/10.4
39hepatic fibrosis susceptibility due to schistosoma mansoni infection10.4
40cerebritis10.3
41proteinuria10.3
42amyloidosis10.2
43myelitis10.2
44bladder carcinoma10.2
45cercarial dermatitis10.2
46hepatitis a10.2
47intestinal disease10.2
48plasmodium malariae malaria10.1
49trachoma10.1
50plasmodium falciparum malaria10.1

Graphical network of the top 20 diseases related to Schistosomiasis:



Diseases related to schistosomiasis

Clinical Features for Schistosomiasis

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46OMIM
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Clinical features from OMIM:

181460

Clinical synopsis from OMIM:

181460

Drugs & Therapeutics for Schistosomiasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Schistosomiasis

Drug clinical trials:

Search ClinicalTrials for Schistosomiasis

Search NIH Clinical Center for Schistosomiasis

Search CenterWatch for Schistosomiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Schistosomiasis

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Anatomical Context for Schistosomiasis

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32MalaCards
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MalaCards organs/tissues related to Schistosomiasis:

32
Liver, Skin, Spleen, Kidney, Lung, Testes, B cells, Spinal cord, Colon, T cells, Appendix, Brain, Endothelial, Monocytes, Cervix, Prostate, Ovary, Breast, Thyroid, Heart

Animal Models for Schistosomiasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Schistosomiasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.9TSPAN32, IFNG, IFNGR1, STAT6, IGHE, CD40LG
2MP:000538710.8CD40LG, IGHE, STAT6, IFNGR1, IFNG, EPX
3MP:000537610.7IFNG, IFNGR1, STAT6, IGHE, CD40LG, IL13
4MP:000537010.7IFNG, IFNGR1, STAT6, IL10, IL5, IL4
5MP:000538910.5IFNGR1, STAT6, IL13
6MP:000536710.5LGMN, IFNGR1
7MP:000537910.4IL4, CD40LG, IFNG
8MP:001077110.3IFNG, IFNGR1, STAT6, CD40LG, IL13, IL10

Publications for Schistosomiasis

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50PubMed
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Articles related to Schistosomiasis:

(show top 50)    (show all 1126)
idTitleAuthorsYear
1
Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals. (24402703)
2014
2
Refolding of the recombinant protein Sm29, a step toward the production of the vaccine candidate against schistosomiasis. (24084635)
2013
3
Advances in the study of schistosomiasis: the postgenomic era. (23589768)
2013
4
Spatially explicit modeling of schistosomiasis risk in eastern China based on a synthesis of epidemiological, environmental and intermediate host genetic data. (23936563)
2013
5
Comparison of data-fitting models for schistosomiasis: a case study in Xingzi, China. (24258889)
2013
6
Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites. (23696708)
2013
7
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. (23505586)
2013
8
Evidence-based treatment of schistosomiasis in pregnancy. (24141548)
2013
9
High prevalence of schistosomiasis in Mbita and its adjacent islands of Lake Victoria, western Kenya. (23206383)
2012
10
A review of female genital schistosomiasis. (22245065)
2012
11
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
12
Do not forget schistosomiasis: a rare cause of changes in ejaculate. (22581886)
2012
13
Schistosomiasis control and snail elimination in China. (23078499)
2012
14
Clinical and imaging characteristics of cerebral schistosomiasis. (21948073)
2012
15
Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children. (22858241)
2012
16
Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region. (22370708)
2012
17
A rare parasitic infection in Turkey: schistosomiasis. Case report. (22627639)
2012
18
Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. (21612808)
2011
19
Evaluation of mammalian and intermediate host surveillance methods for detecting schistosomiasis reemergence in southwest China. (21408127)
2011
20
Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis. (21537683)
2011
21
Integrated prevalence mapping of schistosomiasis, soil-transmitted helminthiasis and malaria in lakeside and island communities in Lake Victoria, Uganda. (22166365)
2011
22
Moderate and high endemicity of schistosomiasis is a predictor of the endemicity of soil-transmitted helminthiasis: a systematic review. (21215979)
2011
23
Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis? (21191519)
2010
24
Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. (21036836)
2010
25
Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria. (20602792)
2010
26
Can coverage of schistosomiasis and soil transmitted helminthiasis control programmes targeting school-aged children be improved? New approaches. (19178756)
2009
27
Urinary schistosomiasis in the Danjarima community in Kano, Nigeria. (19762959)
2009
28
The role of TGFbeta1 and IL-13 in cellular signal transduction of hepatic fibrosis of schistosomiasis]. (20066997)
2009
29
Female genital schistosomiasis--a differential diagnosis to sexually transmitted disease: genital itch and vaginal discharge as indicators of genital Schistosoma haematobium morbidity in a cross-sectional study in endemic rural Zimbabwe. (19055625)
2008
30
Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies? (16380294)
2006
31
Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans. (16428771)
2006
32
Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E. (15213147)
2004
33
Production of interferon-gamma by natural killer cells and aging in chronic human schistosomiasis. (15770048)
2004
34
Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine. (10747267)
2000
35
Oxygen free radical and nitric oxide production in single or combined human schistosomiasis and fascioliasis. (12561894)
1999
36
Validation of reagent sticks in diagnosing urinary schistosomiasis in an urban setting. (8698022)
1996
37
Evaluation of purified antigens in haemagglutination test (IHA) for determination of cross reactivities in diagnosis of fascioliasis and schistosomiasis. (8918041)
1996
38
Urinary schistosomiasis in Nebraska. (7566250)
1995
39
Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis. (7728097)
1995
40
Seeking an appropriate and low cost diagnostic method for intestinal schistosomiasis. (7588659)
1995
41
Urinary schistosomiasis in childhood. (8073544)
1994
42
The pathogenesis of accelerated fibrinolysis in hepatosplenic schistosomiasis. (1489902)
1992
43
Urinary schistosomiasis with cutaneous lesions. (1902604)
1991
44
Acute obstructive urinary schistosomiasis mimicking clinical glomerulonephritis: an unrecognized syndrome. (2482001)
1989
45
Simultaneous use of a sensitive filtration technique and reagent strips in urinary schistosomiasis. (7112663)
1982
46
Serum immunoglobulins in different stages of human intestinal schistosomiasis. (608895)
1977
47
A quantitative post mortem analysis of urinary schistosomiasis in Egypt. II. Evolution and epidemiology. (1190367)
1975
48
Mortality in urinary schistosomiasis. (4196042)
1970
49
Transmission of urinary schistosomiasis after the introduction of snail control: a study of children at the Egypt-49 project by means of an egg-counting technique. (5634130)
1967
50
The effect of CIBA 32,644-Ba in the treatment of 1,059 cases of vesical and intestinal schistosomiasis. (5971129)
1966

Genetic Variations for Schistosomiasis

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Expression for genes affiliated with Schistosomiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schistosomiasis

Search GEO for disease gene expression data for Schistosomiasis.

Pathways for genes affiliated with Schistosomiasis

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7IL4, IFNG, IFNGR1, CD40LG, EPX, RNASE3
2
Hide members
10.6IFNG, IFNGR1, STAT6, CD40LG, IL13, IL10
310.6IFNG, IFNGR1, STAT6, IL13, IL10, IL5
4
Hide members
10.6IFNG, IFNGR1, STAT6, IGHE, IL13, IL5
5
Hide members
10.6PPBP, STAT6, IL13, IL10, IL5, IL4
610.6STAT6, IGHE, CD40LG, IL10, IL5, IL4
710.6IFNG, IL13, IL10, IL5, IL4
810.6IFNG, IL13, IL10, IL5, IL4
9
Hide members
10.6IFNG, IFNGR1, STAT6, IGHE, CD40LG, IL5
10
Hide members
10.6IFNG, CD40LG, IL10, IL5, IL4
1110.6IL4, IL5, IL13, IFNG
1210.6IFNG, CD40LG, IL5, IL4
13
Hide members
10.6IFNG, CD40LG, IL5, IL4
14
Hide members
10.5IFNG, IFNGR1, STAT6, IL10
15
Hide members
10.5IFNG, IFNGR1, STAT6, IL4
16
Hide members
10.5IL5, IL13, STAT6, PPBP
17
Hide members
10.5IL5, IL13, PPBP, IFNGR1
1810.5IL4, IL5, IL13
19
Hide members
10.5IL10, IFNGR1, IFNG
20
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5IFNG, STAT6, IL4
21
Hide members
10.5IL4, STAT6, IFNG
22
Hide members
10.5IL5, IL13, PPBP
2310.5IFNGR1, IFNG

Compounds for genes affiliated with Schistosomiasis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1114.1IFNG, IGHE, STAT6, CD40LG, EPX, RNASE3
2allergens4411.1CD40LG, IL13, IL4, IL5, IL10, RNASE3
3histamine44 28 2413.1IFNG, PPBP, STAT6, IGHE, CD40LG, EPX
4praziquantel44 1112.1IL4, IL10, CD40LG, RNASE3, IL13, IL5
5budesonide44 49 1113.1IGHE, RNASE3, IL13, EPX, IL4, IFNG
6fluticasone propionate44 49 59 1114.1IL13, IL4, IFNG, STAT6, IGHE, IL5
7il-124411.0IL5, IFNG, IL13, IL10, IL4, CD40LG
8montelukast44 49 28 1114.0IL4, IL5, IL10, IL13, RNASE3, IGHE
9salbutamol44 49 28 11 2415.0IL13, RNASE3, EPX, IL5, IGHE, IL10
10thyroxine44 2412.0IL13, SERPINF2, IL4, IL5, CD40LG, IGHE
11tarc4411.0IGHE, IFNG, IL13, IL10, IL5, IL4
12glatiramer acetate44 1112.0IFNG, IL13, IL10, IL5, IL4
13ionomycin4411.0IL5, IL10, IL13, CD40LG, IL4, STAT6
14ivig4411.0IL10, IFNG, IL4, IL5, CD40LG, IGHE
15salmeterol44 49 28 1114.0IL4, EPX, RNASE3, IL13, IL5
16cyclosporin a44 28 5913.0IL4, IL10, IFNG, IGHE, CD40LG, IL5
17prednisolone44 28 1113.0IL5, IL13, RNASE3, IGHE, EPX
18theophylline44 28 11 2414.0IL13, CD40LG, IL10, IL5, RNASE3, EPX
19rantes4411.0RNASE3, CD40LG, IFNG, IL4, PPBP
20vegf4411.0PPBP, RNASE3, SERPINF2, IL5, IL13, IL10
21cysteine4411.0IL13, EPX, CD40LG, IFNG, LGMN, FABP12
22omalizumab44 1112.0IL5, IGHE, IL13, IL4
23alpha-galactosylceramide4410.9IL13, IFNG, IL10, IL4
24pgd24410.9RNASE3, IGHE, IL5, IL13, EPX
25rolipram44 59 2812.9EPX
26sodium cromoglycate4410.9IL5, EPX, IGHE, RNASE3
27nedocromil sodium4410.9IGHE, RNASE3, IL5, IL4
28pge24410.9EPX
29il 104410.9IFNG, IL13, IL5, IL4, IL10
30gm-csf44 2811.9IL10, IFNG
31cetirizine44 28 11 2413.9IGHE, EPX, IL5, RNASE3
32methacholine44 1111.9RNASE3, IL5, IL13, IGHE, IL4
33ovomucoid4410.9IGHE
34heparin44 28 11 2413.9IL13, CD40LG, PPBP, RNASE3, EPX
35ketotifen44 1111.8EPX, IGHE, RNASE3, IL5
36hydrocortisone44 2 59 1113.8IGHE
37penicillin4410.8IL5, IL13, IGHE, PPBP
38azelastine44 1111.8IGHE, IL4, IL5, RNASE3
39thalidomide44 49 59 1113.8IL5, IFNG, IL10, IL13, CD40LG
40endotoxin4410.8RNASE3
41ltc44410.8RNASE3, IL5, IL13, EPX
42leukotriene b444 59 2412.7PPBP, IL13, RNASE3, IL5, EPX
43amphotericin b4410.7IL13
44lactate4410.7IGHE, CD40LG, FABP12, RNASE3, IL13, EPX
45okt34410.7IFNG, IL10, IL4, CD40LG
46arginine4410.6IL13, IL5, CD40LG, SERPINF2, IL4, IFNG
47unicap4410.6RNASE3, IL5, IGHE
48betaseron4410.5IFNG, IL10, IL4
49con a4410.5IFNG, IL5, IL4, IL10
50indomethacin44 59 28 1113.2IL5

GO Terms for genes affiliated with Schistosomiasis

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16Gene Ontology
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Cellular components related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SERPINF2, IL5, IL13, RNASE3, IGHE, PPBP
2extracellular spaceGO:00561510.5SERPINF2, IFNG, PPBP, CD40LG, IL13, IL10
3external side of plasma membraneGO:00989710.3IFNG, CD40LG, IL13, IL4

Biological processes related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.8IL4, IL10, IFNG
2defense response to bacteriumGO:04274210.8IL10, RNASE3, PPBP, IFNG
3defense response to protozoanGO:04283210.8IFNG, IL4, TSPAN32
4positive regulation of B cell proliferationGO:03089010.8IL4, IL5, IL13
5T-helper 1 cell lineage commitmentGO:00229610.8STAT6, IL4
6positive regulation of isotype switching to IgE isotypesGO:04829510.8STAT6, IL4
7regulation of isotype switchingGO:04519110.8IL10, IL4
8negative regulation of myeloid dendritic cell activationGO:03088610.7IL10, TSPAN32
9type 2 immune responseGO:04209210.7IL10, IL4
10B cell differentiationGO:03018310.7IL4, IL10, CD40LG
11regulation of proton transportGO:01015510.7IL13, IL4
12positive regulation of isotype switching to IgG isotypesGO:04830410.6IL4, IFNG
13positive regulation of chemokine biosynthetic processGO:04508010.6IL4, IFNG
14inflammatory responseGO:00695410.6IL5, IL10, IL13, CD40LG
15positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL10, IL5, IL4
16negative regulation of nitric oxide biosynthetic processGO:04501910.4IL4, IL10
17B cell proliferationGO:04210010.2IL10, CD40LG

Molecular functions related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.5IL4, IL5, IL10, PPBP
2cytokine activityGO:00512510.3IL4, IFNG, CD40LG, IL13, IL10, IL5

Products for genes affiliated with Schistosomiasis

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  • Antibodies
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Sources for Schistosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet