MCID: SCH014
MIFTS: 70

Schistosomiasis malady

Rare diseases, Infectious diseases, Blood diseases categories

Summaries for Schistosomiasis

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9Disease Ontology, 44NIH Rare Diseases, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Schistosomiasis is a disease caused by parasitic worms. although the worms that cause schistosomiasis are not found in the united states, more than 200 million people are infected worldwide. infection occurs through contact with contaminated water. the parasite in its infective stages is called a cercaria. it swims freely in open bodies of water. on contact with humans, the parasite burrows into the skin, matures into another stage (schistosomula), then migrates to the lungs and liver, where it matures into the adult form. the adult worm then migrates to its preferred body part (bladder, rectum, intestines, liver, portal venous system (the veins that carry blood from the intestines to liver, spleen, lungs), depending on its species.  schistosomiasis is common in many tropical and subtropical areas worldwide. it can be treated safely and effectively with praziquantel. last updated: 3/15/2013

MalaCards: Schistosomiasis, also known as schistosoma mansoni infection, is related to urinary schistosomiasis and helminthiasis. An important gene associated with Schistosomiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL12 signaling mediated by STAT4 and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug praziquantel and the compounds omalizumab and betaseron have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and spleen, and related mouse phenotypes are tumorigenesis and respiratory system.

Disease Ontology:9 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus schistosoma. the symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

CDC:4 Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the Neglected Tropical Diseases (NTDs).

Wikipedia:66 Schistosomiasis /??ist?s??ma??s?s/ (also known as bilharzia, snail fever, and Katayama fever) is a... more...

Description from OMIM:48 181460

Aliases & Classifications for Schistosomiasis

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44NIH Rare Diseases, 63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 48OMIM, 59SNOMED-CT, 28ICD9CM, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
schistosomiasis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

schistosomiasis 9 44 11 46 50 48 63
schistosoma mansoni infection 44
schistosomiasis japonica 63
katayama fever 44
blood fluke 44
bilharzia 44


External Ids:

Disease Ontology9 DOID:1395
ICD9CM28 120.8
OMIM48 181460
MESH via Orphanet37 D012552
SNOMED-CT via Orphanet60 10087007, 105661001
ICD10 via Orphanet27 B65.0, B65.2, B65.1 B65.3, B65.8, B65.9, more
UMLS via Orphanet64 C0036323

Related Diseases for Schistosomiasis

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18GeneCards, 19GeneDecks
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Diseases related to Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1urinary schistosomiasis31.9AKR7A2
2helminthiasis31.0RNASE3, IL5, IL13
3malaria30.8IFNGR1, IL10, IFNG
4filariasis30.7IL5, IL13
5onchocerciasis30.6IL5, RNASE3, EPX
6strongyloidiasis30.6IL5
7hepatitis c30.5CD40LG, IFNG, IL10
8atopic dermatitis30.5IL4, RNASE3, IL13
9paragonimiasis30.4IL5
10toxocariasis30.2RNASE3
11hepatitis b30.2IFNG, IL10
12esophagitis30.1IL13, IL5
13eosinophilia30.1IL13, IL10, IL4, IFNG, EPX, RNASE3
14plasmodium falciparum malaria30.1IFNG, IL10
15tuberculosis30.0EPX, IFNG, IL4, IL10, IFNGR1
16asthma30.0IL4, IL10, RNASE3, EPX, IL13, IFNG
17eosinophilic pneumonia29.9IL13, IL5, RNASE3
18cerebral malaria29.9IL10, IFNG
19dermatitis29.8IL4, IL13, IL5, IFNG
20pneumonia29.8IL5, EPX, IL10, IL13
21pulmonary tuberculosis29.8IL4, IFNG, IFNGR1, IL10
22leishmaniasis29.7IFNG, IL4, IL5, IL10, IFNGR1, IL13
23intestinal schistosomiasis10.9
24hepatitis10.6
25fascioliasis10.5
26hypertension10.5
27schistosoma mansoni infection, susceptibility/10.4
28hepatic fibrosis susceptibility due to schistosoma mansoni infection10.4
29proteinuria10.3
30cerebritis10.3
31amyloidosis10.3
32myelitis10.2
33transverse myelitis10.2
34cercarial dermatitis10.2
35trachoma10.2
36splenomegaly10.2
37conjunctivitis10.1RNASE3
38collagenous colitis10.1RNASE3
39eosinophilic fasciitis10.1IL5
40chronic rhinitis10.1RNASE3
41aspergillosis10.1IFNG
42eosinophilia-myalgia syndrome10.1IL5
43pancreatitis10.1
44eosinophilic esophagitis10.1IL5
45intraocular lymphoma10.1IL10
46bacteriuria10.1
47portal hypertension10.1
48endomyocardial fibrosis10.1
49clonorchiasis10.1
50dracunculiasis10.1

Graphical network of the top 20 diseases related to Schistosomiasis:



Diseases related to schistosomiasis

Symptoms for Schistosomiasis

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48OMIM
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Symptoms by clinical synopsis from OMIM:

181460

Clinical features from OMIM:

181460

Drugs & Therapeutics for Schistosomiasis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Schistosomiasis

Search NIH Clinical Center for Schistosomiasis

Search CenterWatch for Schistosomiasis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Schistosomiasis

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Anatomical Context for Schistosomiasis

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34MalaCards
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MalaCards organs/tissues related to Schistosomiasis:

34
Liver, Skin, Spleen, Kidney, Lung, Testes, B cells, Spinal cord, Colon, T cells, Appendix, Brain, Endothelial, Monocytes, Cervix, Prostate, Ovary, Thyroid, Heart

Animal Models for Schistosomiasis or affiliated genes

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38MGI
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Publications for Schistosomiasis

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53PubMed
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Articles related to Schistosomiasis:

(show top 50)    (show all 1117)
idTitleAuthorsYear
1
Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals. (24402703)
2014
2
Activity of corilagin on post-parasiticide liver fibrosis in Schistosomiasis animal model. (23527711)
2013
3
Colonic schistosomiasis and associated cecal neuroma. (23923251)
2013
4
A latent markov modelling approach to the evaluation of circulating cathodic antigen strips for schistosomiasis diagnosis pre- and post-praziquantel treatment in Uganda. (24367250)
2013
5
Diagnosis and treatment of schistosomiasis in children in the era of intensified control. (24127662)
2013
6
Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. (23121638)
2013
7
Refolding of the recombinant protein Sm29, a step toward the production of the vaccine candidate against schistosomiasis. (24084635)
2013
8
Effect of school based treatment on the prevalence of schistosomiasis in endemic area in yemen. (23914234)
2013
9
Community health workers' experiences and perspectives on mass drug administration for schistosomiasis control in western Kenya: the SCORE Project. (23091190)
2012
10
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. (23311180)
2012
11
Correlation between acute schistosomiasis japonica and serum interleukin-33 levels]. (22590860)
2012
12
Evidence of intra-hepatic vascular proliferation remodeling early after cure in experimental schistosomiasis mansoni: an immunohistochemical descriptive study. (22019417)
2012
13
Urologic complications of genitourinary schistosomiasis. (21909645)
2012
14
Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction. (21739034)
2011
15
Proportion of Urinary Schistosomiasis among HIV-Infected Subjects in Benin City, Nigeria. (22043410)
2011
16
Colonic schistosomiasis mimicking submucosal tumor. (21287453)
2011
17
Improved mapping strategy to better inform policy on the control of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone. (21645386)
2011
18
Urinary Schistosomiasis around Oyan Reservoir, Nigeria: Twenty Years after the First Outbreak. (23112995)
2010
19
Spatially explicit agent-based modelling for schistosomiasis transmission: human-environment interaction simulation and control strategy assessment. (21352776)
2010
20
Clinical and haemodynamic evaluation of chronic thromboembolic pulmonary hypertension patients scheduled for pulmonary thromboendarterectomy: Is schistosomiasis hypertension an important confounding factor? (21243290)
2010
21
Intestinal schistosomiasis and soil-transmitted helminthiasis in Ugandan schoolchildren: a rapid mapping assessment. (19908189)
2009
22
Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis. (18951599)
2009
23
Evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in Hassoba school children, Afar, Ethiopia. (18416249)
2008
24
Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis. (16624274)
2006
25
Microarray DNA chip in analyzing the association between HLA-DRB and advanced hepatosplenic schistosomiasis]. (16566202)
2005
26
Some molecular aspects in schistosomiasis mansoni and toxoplasmosis. (16333889)
2005
27
Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana. (15361112)
2004
28
Urinary schistosomiasis in Zimbabwean school children: predictors of morbidity. (15477190)
2004
29
Immunoblot analysis of Schistosoma japonicum egg antigens with sera from patients with acute and chronic schistosomiasis japonica. (15115074)
2003
30
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
31
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients. (12100735)
2002
32
Urinary schistosomiasis in schoolchildren on Zanzibar Island (Unguja), Tanzania: a parasitological survey supplemented with questionnaires. (12474477)
2002
33
Prevalence and intensity of urinary schistosomiasis in primary school children of the Kotto Barombi Health Area, Cameroon. (12002103)
2001
34
Urinary schistosomiasis among schoolchildren in Ibadan, an urban community in south-western Nigeria. (10320657)
1999
35
A school-based schistosomiasis and intestinal helminthiasis control programme in Nigeria: acceptability to community members. (9809919)
1998
36
Transmission of intestinal schistosomiasis in Addis Ababa, Ethiopia. (8997864)
1996
37
Identification and characterization of Schistosoma mansoni antigens recognized by T and B lymphocytes of humans with early active intestinal and/or urinary schistosomiasis. (7541026)
1995
38
Urinary schistosomiasis in childhood. (8073544)
1994
39
Lactase deficiency in patients with intestinal schistosomiasis. (17587988)
1993
40
Unilateral optic atrophy presumed secondary to schistosomiasis of the optic nerve. (8335885)
1993
41
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
42
Urinalysis reagent strips in the screening of children for urinary schistosomiasis in the RSA. (3116682)
1987
43
Leads from the MMWR. Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6471329)
1984
44
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
45
The effect of metrifonate on hookworm infections in Kenyan children treated for urinary schistosomiasis. A preliminary report. (6892236)
1982
46
Manifestations of urinary schistosomiasis in a British provincial city. (5162609)
1971
47
Steroid therapy in chronic urinary schistosomiasis (bilharziasis). (6050892)
1967
48
Urinary schistosomiasis. A case report. (5594207)
1967
49
The test of cure in urinary schistosomiasis. (13422576)
1957
50
Cross intradermal reactions of patients with paragonimiasis, clonorchiasis and schistosomiasis to different trematode antigens and their clinical significance. (13277038)
1955

Variations for Schistosomiasis

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Expression for genes affiliated with Schistosomiasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schistosomiasis

Search GEO for disease gene expression data for Schistosomiasis.

Pathways for genes affiliated with Schistosomiasis

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51PathCards, 39NCBI BioSystems Database, 55R&D Systems, 31KEGG, 5Cell Signaling Technology, 61Thomson Reuters, 54QIAGEN, 56Reactome
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Pathways related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNG, IL13
2
Show member pathways
9.8IL10, IFNG
39.8IFNG, IL10
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.7IL4, IFNG
59.5IL4, CD40LG
6
Show member pathways
9.5IFNG, IFNGR1
79.5IFNG, IFNGR1
89.4IL13, IL4, IL5
9
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.4IL4, IL13, IL5
109.2IFNG, CD40LG, IL10
11
Show member pathways
9.2IFNGR1, IL5, IFNG
12
Show member pathways
IL27-mediated signaling events39
9.1IFNG, IL10, IFNGR1
13
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1IFNGR1, IL10, IFNG
149.1IFNG, IL10, IFNGR1
15
Show member pathways
9.1IL10, IL5, IL4, IL13
16
Show member pathways
9.1IL5, IL10, IL13, IL4
179.1IL4, IL5, IFNG, IL13
18
Show member pathways
Immune response CD16 signaling in NK cells61
9.1IFNGR1, IFNG, IL4
19
Show member pathways
9.1IFNGR1, IL4, IFNG
20
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1IFNG, IFNGR1, IL4
218.9IL5, CD40LG, IL10, IL4
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.8CD40LG, IFNG, IL4, IL5
238.8IL5, IFNG, CD40LG, IL4
24
Show member pathways
8.8IFNG, IL13, IL4, IFNGR1
258.7IL13, IL10, IFNG, IL4, IL5
268.7IL13, IL5, IL4, IFNG, IL10
278.7IL5, IL10, IL13, IL4, IFNG
28
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5IFNG, IL10, IL5, IL4, CD40LG
29
Show member pathways
Type III interferon signaling39
8.1IFNGR1, IFNG, IL5, IL10, IL13, IL4
30
Show member pathways
8.1IFNG, IL4, IL5, IL13, IL10, IFNGR1
31
Show member pathways
7.6CD40LG, IL5, IL13, IL10, IL4, IFNG
32
Show member pathways
7.6IL5, IL13, IL4, CD40LG, IFNG, IFNGR1
33
Show member pathways
6.8EPX, CD40LG, IL13, RNASE3, IL10, IL5

Compounds for genes affiliated with Schistosomiasis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1omalizumab46 1210.7IL4, IL5, IL13
2betaseron469.7IL10, IL4, IFNG
3ovomucoid469.6IL4, IL5, IL13
4interferon gamma469.5IFNG, IL4, IL10
5alpha-galactosylceramide469.4IL10, IL4, IL13, IFNG
6amphotericin b469.4IL13, IL4, IFNG, IL5
7methacholine46 52 1211.4IL13, RNASE3, IL4, IL5
8ltc4469.4EPX, IL13, RNASE3, IL5
9sodium cromoglycate469.4IL5, EPX, RNASE3
10con a469.3IFNG, IL4, IL10, IL5
11polyinosinic-polycytidylic acid469.3IL4, IL10, IL5, IFNG
12pgd2469.3RNASE3, IL13, IL5, EPX
13lte4469.3EPX, IL5, RNASE3
14montelukast46 52 30 1212.2IL13, IL5, IL4, RNASE3, IL10
15fluticasone propionate46 52 62 1212.2RNASE3, IFNG, IL4, IL5, IL13
16anti-fungal469.2RNASE3, CD40LG, IL5, IFNG
17pentoxifylline46 1210.2IFNG, IL4, IL10, IL13
18formoterol46 30 1211.2RNASE3, IL4, IL13
19glatiramer acetate46 1210.2IL10, IL5, IFNG, IL4, IL13
20okt3469.2IL4, IFNG, IL10, CD40LG
21gm-csf46 3010.1IL5, IL13, IL10, IFNG, IL4
22il 10469.1IL5, IL4, IL10, IL13, IFNG
23salbutamol46 52 30 25 1213.1IL10, IL5, EPX, IL13, RNASE3
24tarc469.1IL13, IL10, IL5, IFNG, IL4
25hydrocortisone46 3 62 1212.1IFNG, IL10, IL13, IL5, IL4
26salmeterol46 52 30 1212.1RNASE3, IL4, EPX, IL13, IL5
27ribavirin46 52 1211.0IL10, IL4, IFNG, CD40LG
28tacrolimus46 52 1211.0IL13, IFNG, IL4, IL5, IL10
29thalidomide46 52 62 1212.0IL10, CD40LG, IL13, IL5, IFNG
30neopterin468.9IL4, IL10, CD40LG, IFNG
31ivig468.9CD40LG, IL10, IFNG, IL4, IL5
32prednisolone46 30 1210.7IL10, IL5, IFNG, EPX, RNASE3, IL13
33praziquantel46 129.7IL5, IL10, IL13, CD40LG, RNASE3, IL4
34budesonide46 52 1210.7IL13, EPX, IL5, IL4, IFNG, RNASE3
35il-12468.7CD40LG, IFNG, IL5, IL10, IL4, IL13
36rolipram46 62 3010.6IFNG, IL5, IL13, IL4, IL10, EPX
37theophylline46 30 25 1211.6IL13, IL10, IL5, EPX, CD40LG, RNASE3
38ionomycin468.6CD40LG, IL13, IL10, IL5, IL4, IFNG
39indomethacin46 30 62 1211.5IL5, CD40LG, IFNG, IL4, IL13
40rantes468.3RNASE3, IFNG, IL5, IL10, IL13, CD40LG
41cyclosporin a46 30 6210.3RNASE3, IFNG, IL5, IL10, IL13, CD40LG
42endotoxin468.2IL10, RNASE3, SERPINF2, CD40LG, IL13, IFNG
43thyroxine46 259.2IL13, SERPINF2, IL4, IL5, IL10, CD40LG
44heparin46 30 25 1211.0IL13, RNASE3, EPX, CD40LG, IL5, SERPINF2
45allergens467.8CD40LG, IL13, RNASE3, EPX, IFNG, IL4
46histamine46 30 259.8IL13, RNASE3, EPX, IFNG, IL4, CD40LG
47pge2467.8IL4, CD40LG, IL13, IL10, IL5, IFNG
48dexamethasone46 52 30 1210.8IL4, IL5, EPX, IL13, RNASE3, CD40LG
49arginine467.8IFNG, SERPINF2, RNASE3, IL4, IL5, IL13
50vegf467.5IL4, RNASE3, IL5, IL13, IFNG, CD40LG

GO Terms for genes affiliated with Schistosomiasis

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17Gene Ontology
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Cellular components related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CD40LG, IL13, IL4, IFNG
2extracellular regionGO:0055768.4SERPINF2, RNASE3, IFNG, IL5, IL13
3extracellular spaceGO:0056157.3IL5, IFNG, IL10, IL13, CD40LG, SERPINF2

Biological processes related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:01015510.1IL13, IL4
2regulation of isotype switchingGO:04519110.1IL10, IL4
3type 2 immune responseGO:04209210.1IL4, IL10
4negative regulation of growth of symbiont in hostGO:04413010.0IL10, IFNG
5positive regulation of isotype switching to IgG isotypesGO:04830410.0IL4, IFNG
6negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
7positive regulation of chemokine biosynthetic processGO:04508010.0IL4, IFNG
8defense response to protozoanGO:0428329.9IL4, IFNG
9positive regulation of B cell proliferationGO:0308909.8IL13, IL5, IL4
10positive regulation of interleukin-12 productionGO:0327359.8IFNG, CD40LG
11defense response to bacteriumGO:0427429.7IL10, IFNG, RNASE3
12positive regulation of MHC class II biosynthetic processGO:0453489.7IL10, IL4, IFNG
13positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.7IL4, IL5, IL10
14regulation of interferon-gamma-mediated signaling pathwayGO:0603349.7IFNG, IFNGR1
15B cell proliferationGO:0421009.7CD40LG, IL10
16B cell differentiationGO:0301839.5CD40LG, IL10, IL4
17immune responseGO:0069559.4IL13, IL5, IL4
18positive regulation of T cell proliferationGO:0421029.4IL4, IFNG
19response to drugGO:0424939.3IL10, IL4, IFNG
20cytokine-mediated signaling pathwayGO:0192219.3IL5, IFNG, IFNGR1
21inflammatory responseGO:0069549.3IL5, IL10, IL13, CD40LG
22positive regulation of smooth muscle cell proliferationGO:0486619.3SERPINF2, IL13
23positive regulation of transcription from RNA polymerase II promoterGO:0459448.6SERPINF2, IFNG, IL4, IL10

Molecular functions related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.4IL10, IL5, IL4
2cytokine activityGO:0051257.9CD40LG, IL13, IL10, IL5, IL4, IFNG

Products for genes affiliated with Schistosomiasis

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Sources for Schistosomiasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet