MCID: SCH014
MIFTS: 60

Schistosomiasis malady

Rare diseases, Infectious diseases, Blood diseases categories

Summaries for Schistosomiasis

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NIH Rare Diseases:41 Schistosomiasis is a disease caused by parasitic worms. although the worms that cause schistosomiasis are not found in the united states, more than 200 million people are infected worldwide. infection occurs through contact with contaminated water. the parasite in its infective stages is called a cercaria. it swims freely in open bodies of water. on contact with humans, the parasite burrows into the skin, matures into another stage (schistosomula), then migrates to the lungs and liver, where it matures into the adult form. the adult worm then migrates to its preferred body part (bladder, rectum, intestines, liver, portal venous system (the veins that carry blood from the intestines to liver, spleen, lungs), depending on its species.  schistosomiasis is common in many tropical and subtropical areas worldwide. it can be treated safely and effectively with praziquantel. last updated: 3/15/2013

MalaCards based summary: Schistosomiasis, also known as katayama fever, is related to urinary schistosomiasis and filariasis. An important gene associated with Schistosomiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL12 signaling mediated by STAT4 and African trypanosomiasis. The drugs praziquantel and oxamniquine and the compounds omalizumab and betaseron have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and spleen, and related mouse phenotypes are tumorigenesis and respiratory system.

Disease Ontology:9 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus schistosoma. the symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

CDC:3 Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the Neglected Tropical Diseases (NTDs).

Wikipedia:63 Schistosomiasis /??ist?s??ma??s?s/ (also known as bilharzia, snail fever, and Katayama fever) is a... more...

Aliases & Classifications for Schistosomiasis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 27ICD9CM, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Schistosomiasis, Aliases & Descriptions:

Name: Schistosomiasis 9 41 11 43 47 3 60
Katayama Fever 41 60
Bilharzia 41 3
 
Schistosoma Mansoni Infection 41
Schistosomiasis Mansoni 60
Blood Fluke 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
schistosomiasis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:1395
ICD9CM27 120.8
Orphanet47 1247
MESH via Orphanet34 D012552
ICD10 via Orphanet26 B65.0, B65.1, B65.2 B65.3, B65.8, B65.9, more
UMLS via Orphanet61 C0036323

Related Diseases for Schistosomiasis

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Diseases related to Schistosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1urinary schistosomiasis32.5AKR7A2
2filariasis31.2IL13, IL5
3malaria31.2IFNG, IL10
4strongyloidiasis31.1IL5
5paragonimiasis31.0IL5
6toxocariasis30.9RNASE3
7onchocerciasis30.8RNASE3, EPX, IL5
8atopic dermatitis30.8RNASE3, IL4, IL13
9hepatitis c30.6IFNG, IL10, CD40LG
10esophagitis30.5IL5, IL13
11hepatitis b30.4IL10, IFNG
12plasmodium falciparum malaria30.3IFNG, IL10
13eosinophilic pneumonia30.2RNASE3, IL5, IL13
14dermatitis30.2RNASE3, IL4, IL13
15pneumonia29.9EPX, IL5, IL10, IL13
16tuberculosis29.7EPX, IFNGR1, IFNG, IL4, IL10
17pulmonary tuberculosis29.7IFNGR1, IFNG, IL4, IL10
18eosinophilia29.6RNASE3, EPX, IFNG, IL4, IL5, IL10
19asthma29.5RNASE3, EPX, IFNG, IL4, IL5, IL10
20leishmaniasis29.5IFNGR1, IFNG, IL4, IL5, IL10, IL13
21intestinal schistosomiasis10.9
22hepatitis10.7
23conjunctivitis10.6RNASE3
24fascioliasis10.5
25collagenous colitis10.5RNASE3
26eosinophilic fasciitis10.5IL5
27chronic rhinitis10.5RNASE3
28aspergillosis10.5IFNG
29eosinophilia-myalgia syndrome10.5IL5
30esophagitis, eosinophilic, 110.5IL5
31intraocular lymphoma10.5IL10
32kimura disease10.4RNASE3, IL5
33periapical granuloma10.4IL4
34sinusitis10.4RNASE3, IL5
35chronic eosinophilic pneumonia10.4RNASE3, IL5
36giant papillary conjunctivitis10.4RNASE3, IL5
37proteinuria10.4
38hemorrhagic fever10.4CD40LG
39churg-strauss syndrome10.4RNASE3, IL5
40mycobacterium avium complex disease10.4IFNGR1
41cerebritis10.3
42omenn syndrome10.3IL4, IL5
43cutaneous leishmaniasis10.3IFNG, IL10
44tuberculoid leprosy10.3IFNG, IL10
45egg allergy10.3IL4, IL5
46pulmonary hypertension10.3
47allergic bronchopulmonary aspergillosis10.3IL5, IL4
48amyloidosis10.3
49secondary amyloidosis10.3
50mastocytosis10.3IL13, IL5

Graphical network of the top 20 diseases related to Schistosomiasis:



Diseases related to schistosomiasis

Symptoms for Schistosomiasis

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Drugs & Therapeutics for Schistosomiasis

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Drug clinical trials:

Search ClinicalTrials for Schistosomiasis

Search NIH Clinical Center for Schistosomiasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Schistosomiasis

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Anatomical Context for Schistosomiasis

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MalaCards organs/tissues related to Schistosomiasis:

31
Liver, Skin, Spleen, Kidney, Lung, Testes, B cells, Colon, T cells, Appendix, Spinal cord, Brain, Endothelial, Monocytes, Neutrophil, Heart, Thyroid, Breast, Ovary, Prostate, Cervix

Animal Models for Schistosomiasis or affiliated genes

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Publications for Schistosomiasis

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Articles related to Schistosomiasis:

(show top 50)    (show all 1179)
idTitleAuthorsYear
1
Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals. (24402703)
2014
2
Distribution of schistosomiasis and soil transmitted helminthiasis in Zimbabwe: towards a national plan of action for control and elimination. (25121489)
2014
3
Activity of corilagin on post-parasiticide liver fibrosis in Schistosomiasis animal model. (23527711)
2013
4
Colonic schistosomiasis and associated cecal neuroma. (23923251)
2013
5
A latent markov modelling approach to the evaluation of circulating cathodic antigen strips for schistosomiasis diagnosis pre- and post-praziquantel treatment in Uganda. (24367250)
2013
6
Diagnosis and treatment of schistosomiasis in children in the era of intensified control. (24127662)
2013
7
Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. (23121638)
2013
8
Refolding of the recombinant protein Sm29, a step toward the production of the vaccine candidate against schistosomiasis. (24084635)
2013
9
Effect of school based treatment on the prevalence of schistosomiasis in endemic area in yemen. (23914234)
2013
10
Community health workers' experiences and perspectives on mass drug administration for schistosomiasis control in western Kenya: the SCORE Project. (23091190)
2012
11
Prevalence of urinary schistosomiasis in school-aged children in Langai, Plateau State: pre- and post-intervention. (23311180)
2012
12
Correlation between acute schistosomiasis japonica and serum interleukin-33 levels]. (22590860)
2012
13
Evidence of intra-hepatic vascular proliferation remodeling early after cure in experimental schistosomiasis mansoni: an immunohistochemical descriptive study. (22019417)
2012
14
Urologic complications of genitourinary schistosomiasis. (21909645)
2012
15
Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction. (21739034)
2011
16
Proportion of Urinary Schistosomiasis among HIV-Infected Subjects in Benin City, Nigeria. (22043410)
2011
17
Colonic schistosomiasis mimicking submucosal tumor. (21287453)
2011
18
Improved mapping strategy to better inform policy on the control of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone. (21645386)
2011
19
Urinary Schistosomiasis around Oyan Reservoir, Nigeria: Twenty Years after the First Outbreak. (23112995)
2010
20
Spatially explicit agent-based modelling for schistosomiasis transmission: human-environment interaction simulation and control strategy assessment. (21352776)
2010
21
Clinical and haemodynamic evaluation of chronic thromboembolic pulmonary hypertension patients scheduled for pulmonary thromboendarterectomy: Is schistosomiasis hypertension an important confounding factor? (21243290)
2010
22
Intestinal schistosomiasis and soil-transmitted helminthiasis in Ugandan schoolchildren: a rapid mapping assessment. (19908189)
2009
23
Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis. (18951599)
2009
24
Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis. (16624274)
2006
25
Microarray DNA chip in analyzing the association between HLA-DRB and advanced hepatosplenic schistosomiasis]. (16566202)
2005
26
Some molecular aspects in schistosomiasis mansoni and toxoplasmosis. (16333889)
2005
27
Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana. (15361112)
2004
28
Urinary schistosomiasis in Zimbabwean school children: predictors of morbidity. (15477190)
2004
29
Immunoblot analysis of Schistosoma japonicum egg antigens with sera from patients with acute and chronic schistosomiasis japonica. (15115074)
2003
30
Recent advances in research and control of malaria, leishmaniasis, trypanosomiasis and schistosomiasis. (15748049)
2003
31
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients. (12100735)
2002
32
Urinary schistosomiasis in schoolchildren on Zanzibar Island (Unguja), Tanzania: a parasitological survey supplemented with questionnaires. (12474477)
2002
33
Prevalence and intensity of urinary schistosomiasis in primary school children of the Kotto Barombi Health Area, Cameroon. (12002103)
2001
34
Urinary schistosomiasis among schoolchildren in Ibadan, an urban community in south-western Nigeria. (10320657)
1999
35
A school-based schistosomiasis and intestinal helminthiasis control programme in Nigeria: acceptability to community members. (9809919)
1998
36
Transmission of intestinal schistosomiasis in Addis Ababa, Ethiopia. (8997864)
1996
37
Identification and characterization of Schistosoma mansoni antigens recognized by T and B lymphocytes of humans with early active intestinal and/or urinary schistosomiasis. (7541026)
1995
38
Urinary schistosomiasis in childhood. (8073544)
1994
39
Lactase deficiency in patients with intestinal schistosomiasis. (17587988)
1993
40
Unilateral optic atrophy presumed secondary to schistosomiasis of the optic nerve. (8335885)
1993
41
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
42
Urinalysis reagent strips in the screening of children for urinary schistosomiasis in the RSA. (3116682)
1987
43
Leads from the MMWR. Acute schistosomiasis with transverse myelitis in American students returning from Kenya. (6471329)
1984
44
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
45
The effect of metrifonate on hookworm infections in Kenyan children treated for urinary schistosomiasis. A preliminary report. (6892236)
1982
46
Manifestations of urinary schistosomiasis in a British provincial city. (5162609)
1971
47
Steroid therapy in chronic urinary schistosomiasis (bilharziasis). (6050892)
1967
48
Urinary schistosomiasis. A case report. (5594207)
1967
49
The test of cure in urinary schistosomiasis. (13422576)
1957
50
Cross intradermal reactions of patients with paragonimiasis, clonorchiasis and schistosomiasis to different trematode antigens and their clinical significance. (13277038)
1955

Variations for Schistosomiasis

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Expression for genes affiliated with Schistosomiasis

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Search GEO for disease gene expression data for Schistosomiasis.

Pathways for genes affiliated with Schistosomiasis

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Pathways related to Schistosomiasis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL13, IFNG
29.8IL10, IFNG
3
Show member pathways
9.8IL10, IFNG
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.7IL4, IFNG
59.5CD40LG, IL4
6
Show member pathways
9.5IFNG, IFNGR1
79.5IFNG, IFNGR1
8
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.4IL4, IL5, IL13
99.4IL13, IL5, IL4
109.2CD40LG, IL10, IFNG
11
Show member pathways
9.2IFNGR1, IFNG, IL5
129.1IL10, IFNG, IFNGR1
13
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1IFNGR1, IFNG, IL10
14
Show member pathways
IL27-mediated signaling events36
9.1IFNGR1, IFNG, IL10
15
Show member pathways
9.1IL4, IL5, IL10, IL13
16
Show member pathways
9.1IL4, IL5, IL10, IL13
17
Show member pathways
Immune response CD16 signaling in NK cells58
9.1IL4, IFNG, IFNGR1
18
Show member pathways
9.1IL4, IFNG, IFNGR1
19
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1IFNGR1, IFNG, IL4
209.1IFNG, IL4, IL5, IL13
218.9IL4, IL5, IL10, CD40LG
228.8CD40LG, IL5, IL4, IFNG
23
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.8CD40LG, IL5, IL4, IFNG
24
Show member pathways
8.8IL13, IL4, IFNG, IFNGR1
258.7IL13, IL10, IL5, IL4, IFNG
268.7IFNG, IL4, IL5, IL10, IL13
278.7IFNG, IL4, IL5, IL10, IL13
28
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5IFNG, IL4, IL5, IL10, CD40LG
29
Show member pathways
Type III interferon signaling36
8.1IFNGR1, IFNG, IL4, IL5, IL10, IL13
30
Show member pathways
8.1IFNGR1, IFNG, IL4, IL5, IL10, IL13
31
Show member pathways
7.6IFNGR1, IFNG, IL4, IL5, IL10, IL13
32
Show member pathways
7.6IFNGR1, IFNG, IL4, IL5, IL10, IL13
33
Show member pathways
6.8CD40LG, RNASE3, EPX, IFNGR1, IFNG, IL4

Compounds for genes affiliated with Schistosomiasis

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Compounds related to Schistosomiasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1omalizumab43 1210.7IL4, IL5, IL13
2betaseron439.7IL10, IL4, IFNG
3ovomucoid439.6IL4, IL5, IL13
4interferon gamma439.5IFNG, IL4, IL10
5alpha-galactosylceramide439.4IL10, IL4, IL13, IFNG
6amphotericin b439.4IL13, IL4, IFNG, IL5
7methacholine43 49 1211.4IL13, RNASE3, IL4, IL5
8ltc4439.4EPX, IL13, RNASE3, IL5
9sodium cromoglycate439.4IL5, EPX, RNASE3
10con a439.3IFNG, IL4, IL10, IL5
11polyinosinic-polycytidylic acid439.3IL4, IL10, IL5, IFNG
12pgd2439.3RNASE3, IL13, IL5, EPX
13lte4439.3EPX, IL5, RNASE3
14montelukast43 49 28 1212.2IL13, IL5, IL4, RNASE3, IL10
15fluticasone propionate43 49 59 1212.2RNASE3, IFNG, IL4, IL5, IL13
16anti-fungal439.2RNASE3, CD40LG, IL5, IFNG
17pentoxifylline43 1210.2IFNG, IL4, IL10, IL13
18formoterol43 28 1211.2RNASE3, IL4, IL13
19glatiramer acetate43 1210.2IL10, IL5, IFNG, IL4, IL13
20okt3439.2IL4, IFNG, IL10, CD40LG
21gm-csf43 2810.1IL5, IL13, IL10, IFNG, IL4
22il 10439.1IL5, IL4, IL10, IL13, IFNG
23salbutamol43 49 28 24 1213.1IL10, IL5, EPX, IL13, RNASE3
24tarc439.1IL13, IL10, IL5, IFNG, IL4
25hydrocortisone43 2 59 1212.1IFNG, IL10, IL13, IL5, IL4
26salmeterol43 49 28 1212.1RNASE3, IL4, EPX, IL13, IL5
27ribavirin43 49 1211.0IL10, IL4, IFNG, CD40LG
28tacrolimus43 49 1211.0IL13, IFNG, IL4, IL5, IL10
29thalidomide43 49 59 1212.0IL10, CD40LG, IL13, IL5, IFNG
30neopterin438.9IL4, IL10, CD40LG, IFNG
31ivig438.9CD40LG, IL10, IFNG, IL4, IL5
32prednisolone43 28 1210.7IL10, IL5, IFNG, EPX, RNASE3, IL13
33praziquantel43 129.7IL5, IL10, IL13, CD40LG, RNASE3, IL4
34budesonide43 49 1210.7IL13, EPX, IL5, IL4, IFNG, RNASE3
35il-12438.7CD40LG, IFNG, IL5, IL10, IL4, IL13
36rolipram43 59 2810.6IFNG, IL5, IL13, IL4, IL10, EPX
37theophylline43 28 24 1211.6IL13, IL10, IL5, EPX, CD40LG, RNASE3
38ionomycin438.6CD40LG, IL13, IL10, IL5, IL4, IFNG
39indomethacin43 28 59 1211.5IL5, CD40LG, IFNG, IL4, IL13
40rantes438.3RNASE3, IFNG, IL5, IL10, IL13, CD40LG
41cyclosporin a43 28 5910.3RNASE3, IFNG, IL5, IL10, IL13, CD40LG
42endotoxin438.2IL10, RNASE3, SERPINF2, CD40LG, IL13, IFNG
43thyroxine43 249.2IL13, SERPINF2, IL4, IL5, IL10, CD40LG
44heparin43 28 24 1211.0IL13, RNASE3, EPX, CD40LG, IL5, SERPINF2
45allergens437.8CD40LG, IL13, RNASE3, EPX, IFNG, IL4
46histamine43 28 249.8IL13, RNASE3, EPX, IFNG, IL4, CD40LG
47pge2437.8IL4, CD40LG, IL13, IL10, IL5, IFNG
48dexamethasone43 49 28 1210.8IL4, IL5, EPX, IL13, RNASE3, CD40LG
49arginine437.8IFNG, SERPINF2, RNASE3, IL4, IL5, IL13
50vegf437.5IL4, RNASE3, IL5, IL13, IFNG, CD40LG

GO Terms for genes affiliated with Schistosomiasis

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Cellular components related to Schistosomiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6IFNG, IL4, IL13, CD40LG
2extracellular regionGO:00055768.4IL13, IL5, IFNG, RNASE3, SERPINF2
3extracellular spaceGO:00056157.3CD40LG, IL13, IL10, IL5, IL4, IFNG

Biological processes related to Schistosomiasis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:001015510.1IL13, IL4
2regulation of isotype switchingGO:004519110.1IL10, IL4
3type 2 immune responseGO:004209210.1IL4, IL10
4negative regulation of growth of symbiont in hostGO:004413010.0IL10, IFNG
5positive regulation of isotype switching to IgG isotypesGO:004830410.0IL4, IFNG
6negative regulation of nitric oxide biosynthetic processGO:004501910.0IL4, IL10
7positive regulation of chemokine biosynthetic processGO:004508010.0IL4, IFNG
8defense response to protozoanGO:00428329.9IL4, IFNG
9positive regulation of B cell proliferationGO:00308909.8IL13, IL5, IL4
10positive regulation of interleukin-12 productionGO:00327359.8IFNG, CD40LG
11defense response to bacteriumGO:00427429.7IL10, IFNG, RNASE3
12positive regulation of MHC class II biosynthetic processGO:00453489.7IL10, IL4, IFNG
13positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL4, IL5, IL10
14regulation of interferon-gamma-mediated signaling pathwayGO:00603349.7IFNG, IFNGR1
15B cell proliferationGO:00421009.7CD40LG, IL10
16B cell differentiationGO:00301839.5CD40LG, IL10, IL4
17immune responseGO:00069559.4IL13, IL5, IL4
18positive regulation of T cell proliferationGO:00421029.4IL4, IFNG
19response to drugGO:00424939.3IL10, IL4, IFNG
20cytokine-mediated signaling pathwayGO:00192219.3IL5, IFNG, IFNGR1
21inflammatory responseGO:00069549.3IL5, IL10, IL13, CD40LG
22positive regulation of smooth muscle cell proliferationGO:00486619.3SERPINF2, IL13
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.6SERPINF2, IFNG, IL4, IL10

Molecular functions related to Schistosomiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.4IL10, IL5, IL4
2cytokine activityGO:00051257.9CD40LG, IL13, IL10, IL5, IL4, IFNG

Products for genes affiliated with Schistosomiasis

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Sources for Schistosomiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet