MCID: SCH014
MIFTS: 59

Schistosomiasis malady

Infectious category

Summaries for Schistosomiasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Schistosomiasis is a disease caused by parasitic worms. although the worms that cause schistosomiasis are not found in the united states, more than 200 million people are infected worldwide. infection occurs through contact with contaminated water. the parasite in its infective stages is called a cercaria. it swims freely in open bodies of water. on contact with humans, the parasite burrows into the skin, matures into another stage (schistosomula), then migrates to the lungs and liver, where it matures into the adult form. the adult worm then migrates to its preferred body part (bladder, rectum, intestines, liver, portal venous system (the veins that carry blood from the intestines to liver, spleen, lungs), depending on its species.  schistosomiasis is common in many tropical and subtropical areas worldwide. it can be treated safely and effectively with praziquantel. last updated: 3/15/2013

MalaCards: Schistosomiasis, also known as schistosoma mansoni infection, is related to urinary schistosomiasis and intestinal schistosomiasis. An important gene associated with Schistosomiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Allograft rejection and Leishmaniasis. The drug praziquantel and the compounds dexamethasone and allergens have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus schistosoma. the symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

CDC:3 Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the Neglected Tropical Diseases (NTDs).

Wikipedia:64 Schistosomiasis /ˌʃistəsɵˈmaɪəsəs/ (also known as bilharzia, bilharziasis or snail fever) is a... more...

Description from OMIM:47 181460

Aliases & Classifications for Schistosomiasis

Sources:
43NIH Rare Diseases, 61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
schistosomiasis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

schistosomiasis 8 43 10 45 49 47 61
schistosoma mansoni infection 43
schistosomiasis japonica 61
katayama fever 43
blood fluke 43
bilharzia 43


External Ids:

Disease Ontology8 DOID:1395
ICD9CM27 120.8
OMIM47 181460
MESH via Orphanet36 D012552
ICD10 via Orphanet26 B65
SNOMED-CT via Orphanet58 10087007, 105661001
UMLS via Orphanet62 C0036323

Related Diseases for Schistosomiasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Schistosomiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1urinary schistosomiasis31.7AKR7A2
2intestinal schistosomiasis31.3MRGPRE, MRGPRF
3helminthiasis30.9IL5, IL13, RNASE3, IGHE
4onchocerciasis30.5EPX, RNASE3, IL5
5hepatitis c30.4IL4, IL10, CD40LG, IFNG
6atopic dermatitis30.4IL4, IL13, RNASE3, STAT6
7strongyloidiasis30.4IGHE, IL5
8paragonimiasis30.2IGHE, IL5
9asthma30.1IFNG, PPBP, STAT6, IGHE, EPX, RNASE3
10tuberculosis30.1IL4, IL10, EPX, IFNGR1, IFNG
11toxocariasis30.0IGHE, RNASE3
12toxoplasmosis30.0CD40LG
13pulmonary tuberculosis29.8IL4, IL10, IFNGR1, IFNG
14paracoccidioidomycosis29.8IL10
15hepatitis b29.8IFNG
16vascular disease29.8IL10, SERPINF2
17thrombocytopenia29.8CD40LG, PPBP
18colorectal cancer29.8LGMN
19fascioliasis10.5
20hepatic fibrosis susceptibility due to schistosoma mansoni infection10.4
21amyloidosis10.3
22amyloidosis, secondary10.3
23hepatitis a10.3
24myelitis10.2
25hepatitis e10.2
26bladder carcinoma10.2
27transverse myelitis10.2
28cercarial dermatitis10.2
29trachoma10.2
30plasmodium falciparum malaria10.2
31splenomegaly10.2
32bacteriuria10.1
33portal hypertension10.1
34endomyocardial fibrosis10.1
35hepatitis d10.1
36dracunculiasis10.1
37clonorchiasis10.1
38bladder squamous cell carcinoma10.1
39squamous cell carcinoma10.1
40ectopic pregnancy10.1
41goblet cell carcinoid10.1
42hepatitis c virus10.1
43acute transverse myelitis10.1
44splenic disease10.0
45ascariasis10.0
46ancylostomiasis10.0
47portal vein thrombosis10.0
48meckel's diverticulitis10.0
49verrucous carcinoma10.0
50neuroschistosomiasis10.0

Graphical network of the top 20 diseases related to Schistosomiasis:



Diseases related to schistosomiasis

Clinical Features for Schistosomiasis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

181460

Clinical synopsis from OMIM:

181460

Drugs & Therapeutics for Schistosomiasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Schistosomiasis

Drug clinical trials:

Search ClinicalTrials for Schistosomiasis

Search NIH Clinical Center for Schistosomiasis

Search CenterWatch for Schistosomiasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Schistosomiasis

Anatomical Context for Schistosomiasis

Animal Models for Schistosomiasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Schistosomiasis

Sources:
51PubMed
See all sources

Articles related to Schistosomiasis:

(show top 50)    (show all 1126)
idTitleAuthorsYear
1
Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area, Nigeria. (24418080)
2014
2
Immunopathological aspects of schistosomiasis-associated pulmonary arterial hypertension. (23954614)
2014
3
Long term study on the effect of mollusciciding with niclosamide in stream habitats on the transmission of schistosomiasis mansoni after community-based chemotherapy in Makueni District, Kenya. (23596985)
2013
4
Health access livelihood framework reveals potential barriers in the control of schistosomiasis in the Dongting Lake area of Hunan Province, China. (23936580)
2013
5
Urogenital schistosomiasis in women of reproductive age and pregnant mothers in Kwale County, Kenya. (24103656)
2013
6
Monocyte chemotactic protein-1 (MCP-1) in patients with chronic schistosomiasis mansoni: evidences of subclinical renal inflammation. (24265821)
2013
7
Schistosomiasis and impaired response to antiretroviral therapy among HIV-infected patients in Tanzania. (23760064)
2013
8
Large-scale determinants of intestinal schistosomiasis and intermediate host snail distribution across Africa: does climate matter? (22142789)
2013
9
Urologic complications of genitourinary schistosomiasis. (21909645)
2012
10
Adjuvant selection for vaccination against murine schistosomiasis. (22882457)
2012
11
Mapping of schistosomiasis and soil-transmitted helminthiasis in the regions of centre, East and West Cameroon. (22413029)
2012
12
Induction and regulation of pathogenic Th17 cell responses in schistosomiasis. (23096253)
2012
13
Magnetic affinity enzyme-linked immunoassay for diagnosis of Schistosomiasis japonicum in persons with low-intensity infection. (22869635)
2012
14
Systematic review of pentachlorophenol occurrence in the environment and in humans in China: not a negligible health risk due to the re-emergence of schistosomiasis. (21601283)
2012
15
The role of target therapies in schistosomiasis-associated pulmonary arterial hypertension. (22030800)
2012
16
Schistosomiasis in 2012: current status and key research priorities required for control leading to elimination. (23241179)
2012
17
Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis? (23006852)
2012
18
Schistosomiasis. (22441065)
2012
19
Successful control of schistosomiasis and the changing epidemiology of bladder cancer in Egypt. (21208365)
2011
20
Stirred, not shaken: genetic structure of the intermediate snail host Oncomelania hupensis robertsoni in an historically endemic schistosomiasis area. (22029536)
2011
21
Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review. (21949893)
2011
22
Impact of temperature and precipitation on propagation of intestinal schistosomiasis in an irrigated region in Ethiopia: suitability of satellite datasets. (21767333)
2011
23
The challenge of effective surveillance in moving from low transmission to elimination of schistosomiasis in China. (21920366)
2011
24
Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali. (21338486)
2011
25
An outbreak of acute schistosomiasis following a church retreat to Mwanza, Tanzania, 2008. (22017717)
2011
26
Urinary Schistosomiasis around Oyan Reservoir, Nigeria: Twenty Years after the First Outbreak. (23112995)
2010
27
Age and gender effects in self-reported urinary schistosomiasis in Tanzania. (18419586)
2008
28
Discriminating acute from chronic human schistosomiasis mansoni. (18851939)
2008
29
Cytokines, chemokine receptors, CD4+CD25HIGH+ T-cells and clinical forms of human schistosomiasis. (18534548)
2008
30
Bayesian spatial analysis of a national urinary schistosomiasis questionnaire to assist geographic targeting of schistosomiasis control in Tanzania, East Africa. (17920605)
2008
31
Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria. (16714563)
2006
32
Elevated serum levels of TNF-alpha, sTNF-RI and sTNF-RII in murine schistosomiasis correlate with schistosome oviposition and circumoval granuloma formation. (11594791)
2001
33
Production of Sm37-GAPDH, a major therapeutical target in human schistosomiasis. (10712729)
2000
34
Biochemical changes in patients with combined chronic schistosomiasis and viral hepatitis C infections. (11381190)
2000
35
The prevalence, incidence and distribution of human urinary schistosomiasis in Edo State, Nigeria. (11215021)
2000
36
Pathogenetic factors of acute schistosomiasis mansoni: correlation of worm burden, IgE, blood eosinophilia and intensity of clinical manifestations. (8665387)
1996
37
Limited field evaluation of a rapid monoclonal antibody-based dipstick assay for urinary schistosomiasis. (8985756)
1996
38
Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt. (8795591)
1996
39
Decline of urinary schistosomiasis in Kurmuk town, western Ethio-Sudanese border, Ethiopia. (8674500)
1996
40
Immunopathogenesis and immunoregulation in schistosomiasis. Distinct chronic pathologic syndromes in CBA/J mice. (8993359)
1996
41
The immunopathology of human Schistosomiasis-III. Immunoglobulin isotype profiles and response to praziquantel. (9137744)
1996
42
Prevalence and severity of urinary schistosomiasis in Ibadan, Nigeria. (8904071)
1995
43
Polyserositis in a patient with acute paracoccidioidomycosis and hepatosplenic schistosomiasis. (7566060)
1995
44
IgA antibodies to a protective antigen in human Schistosomiasis mansoni. (8419485)
1993
45
Circulating growth hormone, insulin-like growth factor I, cortisol and free thyroxine in children with schistosomiasis with and without hepatic fibrosis. (2023299)
1991
46
Screening and treatment of urinary schistosomiasis in Dar es Salaam. (3102735)
1987
47
Morbidity from urinary schistosomiasis in relation to intensity of infection in the Natal Province of South Africa. (3089036)
1986
48
Antibody responses in murine schistosomiasis and fascioliasis. (6773428)
1980
49
Further experience on the use of oxamniquine in the treatment of advanced intestinal schistosomiasis. (534452)
1979
50
The test of cure in urinary schistosomiasis. (13422576)
1957

Genetic Variations for Schistosomiasis

Expression for genes affiliated with Schistosomiasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Schistosomiasis

Search GEO for disease gene expression data for Schistosomiasis.

Pathways for genes affiliated with Schistosomiasis

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7IL4, IFNG, IFNGR1, CD40LG, EPX, RNASE3
2
Hide members
10.6IFNG, IFNGR1, STAT6, CD40LG, IL13, IL10
310.6IFNG, IFNGR1, STAT6, IL13, IL10, IL5
4
Hide members
10.6IFNG, IFNGR1, STAT6, IGHE, IL13, IL5
5
Hide members
10.6PPBP, STAT6, IL13, IL10, IL5, IL4
610.6STAT6, IGHE, CD40LG, IL10, IL5, IL4
710.6IFNG, IL13, IL10, IL5, IL4
810.6IFNG, IL13, IL10, IL5, IL4
9
Hide members
10.6IFNG, IFNGR1, STAT6, IGHE, CD40LG, IL5
10
Hide members
10.6IFNG, CD40LG, IL10, IL5, IL4
1110.6IL4, IL5, IL13, IFNG
1210.6IFNG, CD40LG, IL5, IL4
13
Hide members
10.6IFNG, CD40LG, IL5, IL4
14
Hide members
10.5IFNG, IFNGR1, STAT6, IL10
15
Hide members
10.5IFNG, IFNGR1, STAT6, IL4
16
Hide members
10.5IL5, IL13, STAT6, PPBP
17
Hide members
10.5IL5, IL13, PPBP, IFNGR1
1810.5IL4, IL5, IL13
19
Hide members
10.5IL10, IFNGR1, IFNG
20
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.5IFNG, STAT6, IL4
21
Hide members
10.5IL4, STAT6, IFNG
22
Hide members
10.5IL5, IL13, PPBP
2310.5IFNGR1, IFNG

Compounds for genes affiliated with Schistosomiasis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Schistosomiasis according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1114.1IFNG, IGHE, STAT6, CD40LG, EPX, RNASE3
2allergens4511.1CD40LG, IL13, IL4, IL5, IL10, RNASE3
3histamine45 29 2413.1IFNG, PPBP, STAT6, IGHE, CD40LG, EPX
4praziquantel45 1112.1IL4, IL10, CD40LG, RNASE3, IL13, IL5
5budesonide45 50 1113.1IGHE, RNASE3, IL13, EPX, IL4, IFNG
6fluticasone propionate45 50 60 1114.1IL13, IL4, IFNG, STAT6, IGHE, IL5
7il-124511.0IL5, IFNG, IL13, IL10, IL4, CD40LG
8montelukast45 50 29 1114.0IL4, IL5, IL10, IL13, RNASE3, IGHE
9salbutamol45 50 29 11 2415.0IL13, RNASE3, EPX, IL5, IGHE, IL10
10thyroxine45 2412.0IL13, SERPINF2, IL4, IL5, CD40LG, IGHE
11tarc4511.0IGHE, IFNG, IL13, IL10, IL5, IL4
12glatiramer acetate45 1112.0IFNG, IL13, IL10, IL5, IL4
13ionomycin4511.0IL5, IL10, IL13, CD40LG, IL4, STAT6
14ivig4511.0IL10, IFNG, IL4, IL5, CD40LG, IGHE
15salmeterol45 50 29 1114.0IL4, EPX, RNASE3, IL13, IL5
16cyclosporin a45 29 6013.0IL4, IL10, IFNG, IGHE, CD40LG, IL5
17prednisolone45 29 1113.0IL5, IL13, RNASE3, IGHE, EPX
18theophylline45 29 11 2414.0IL13, CD40LG, IL10, IL5, RNASE3, EPX
19rantes4511.0RNASE3, CD40LG, IFNG, IL4, PPBP
20vegf4511.0PPBP, RNASE3, SERPINF2, IL5, IL13, IL10
21cysteine4511.0IL13, EPX, CD40LG, IFNG, LGMN, FABP12
22omalizumab45 1112.0IL5, IGHE, IL13, IL4
23alpha-galactosylceramide4510.9IL13, IFNG, IL10, IL4
24pgd24510.9RNASE3, IGHE, IL5, IL13, EPX
25rolipram45 60 2912.9EPX
26sodium cromoglycate4510.9IL5, EPX, IGHE, RNASE3
27nedocromil sodium4510.9IGHE, RNASE3, IL5, IL4
28pge24510.9EPX
29il 104510.9IFNG, IL13, IL5, IL4, IL10
30gm-csf45 2911.9IL10, IFNG
31cetirizine45 29 11 2413.9IGHE, EPX, IL5, RNASE3
32methacholine45 1111.9RNASE3, IL5, IL13, IGHE, IL4
33ovomucoid4510.9IGHE
34heparin45 29 11 2413.9IL13, CD40LG, PPBP, RNASE3, EPX
35ketotifen45 1111.8EPX, IGHE, RNASE3, IL5
36hydrocortisone45 2 60 1113.8IGHE
37penicillin4510.8IL5, IL13, IGHE, PPBP
38azelastine45 1111.8IGHE, IL4, IL5, RNASE3
39thalidomide45 50 60 1113.8IL5, IFNG, IL10, IL13, CD40LG
40endotoxin4510.8RNASE3
41ltc44510.8RNASE3, IL5, IL13, EPX
42leukotriene b445 60 2412.7PPBP, IL13, RNASE3, IL5, EPX
43amphotericin b4510.7IL13
44lactate4510.7IGHE, CD40LG, FABP12, RNASE3, IL13, EPX
45okt34510.7IFNG, IL10, IL4, CD40LG
46arginine4510.6IL13, IL5, CD40LG, SERPINF2, IL4, IFNG
47unicap4510.6RNASE3, IL5, IGHE
48betaseron4510.5IFNG, IL10, IL4
49con a4510.5IFNG, IL5, IL4, IL10
50indomethacin45 60 29 1113.2IL5

GO Terms for genes affiliated with Schistosomiasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6SERPINF2, IL5, IL13, RNASE3, IGHE, PPBP
2extracellular spaceGO:00561510.5SERPINF2, IFNG, PPBP, CD40LG, IL13, IL10
3external side of plasma membraneGO:00989710.3IFNG, CD40LG, IL13, IL4

Biological processes related to Schistosomiasis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.8IL4, IL10, IFNG
2defense response to bacteriumGO:04274210.8IL10, RNASE3, PPBP, IFNG
3defense response to protozoanGO:04283210.8IFNG, IL4, TSPAN32
4positive regulation of B cell proliferationGO:03089010.8IL4, IL5, IL13
5T-helper 1 cell lineage commitmentGO:00229610.8STAT6, IL4
6positive regulation of isotype switching to IgE isotypesGO:04829510.8STAT6, IL4
7regulation of isotype switchingGO:04519110.8IL10, IL4
8negative regulation of myeloid dendritic cell activationGO:03088610.7IL10, TSPAN32
9type 2 immune responseGO:04209210.7IL10, IL4
10B cell differentiationGO:03018310.7IL4, IL10, CD40LG
11regulation of proton transportGO:01015510.7IL13, IL4
12positive regulation of isotype switching to IgG isotypesGO:04830410.6IL4, IFNG
13positive regulation of chemokine biosynthetic processGO:04508010.6IL4, IFNG
14inflammatory responseGO:00695410.6IL5, IL10, IL13, CD40LG
15positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL10, IL5, IL4
16negative regulation of nitric oxide biosynthetic processGO:04501910.4IL4, IL10
17B cell proliferationGO:04210010.2IL10, CD40LG

Molecular functions related to Schistosomiasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.5IL4, IL5, IL10, PPBP
2cytokine activityGO:00512510.3IL4, IFNG, CD40LG, IL13, IL10, IL5

Products for genes affiliated with Schistosomiasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Schistosomiasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet