Schistosomiasis malady

CDC: Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. Although the worms that cause schistosomiasis are not found in the United States, more than 200 million people are infected worldwide. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Schistosomiasis is considered one of the Neglected Tropical Diseases (NTDs).²

MalaCards: Schistosomiasis, also known as schistosoma mansoni infection, is related to urinary schistosomiasis and intestinal schistosomiasis. An important gene associated with Schistosomiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are OX40 Pathway and Graft-versus-host disease. The drug praziquantel and the compounds allergens and sp 600125 have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and skin, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus schistosoma. the symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.⁶

Wikipedia: Schistosomiasis (also known as bilharzia, bilharziosis or snail fever) is a parasitic disease caused by...⁴⁴ more...

Aliases & Descriptions:

schistosomiasis 6 30 8 32 43 schistosoma mansoni infection 30 katayama fever 30

blood fluke 30 bilharzia 30

Diseases related to schistosomiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1007)

id	Related Disease	Score	Top Affiliating Genes
1	urinary schistosomiasis	34.7	ARAP2, IL10, IL13, IL4, IL5, IGHE
2	intestinal schistosomiasis	32.8	IL13, IL5, HSPA8
3	hepatitis	30.5	GUSB, ARG1, GSR, FAS, GPT, IFNA2
4	atopic dermatitis	30.5	SELE, NAT2, CD86, IL10, IL13, IL1A
5	malaria	29.9	CD40LG, IL10, IL1A, IL4, IFNG, TNF
6	alcoholism	29.0	CHRM2, GSR, GPT, ABCB7, SLC17A5, CP
7	onchocerciasis	27.9	IL10, IL13, IL4, IL5, CCL5, IGHE
8	hepatitis c	27.8	CD40LG, GSR, IL10, IL2, IL4, FAS
9	plasmodium falciparum malaria	27.5	SELE, GSR, IL10, IFNG, HSPA8, HMGB1
10	fascioliasis	27.5	SELE, GUSB, INS, IL10, FABP12, IFNG
11	asthma	27.3	SERPINE1, IL13, IL4, IL9, CCL2, CCR5
12	portal hypertension	27.3	GPT, F2, ALB, EDN1, THPO, SLC17A5
13	alcoholic liver cirrhosis	27.3	NAT2, LCAT, GSTM1, GPT, F2, ALB
14	immunodeficiency	27.2	BMP6, CHRM2, CD79A, CD4, CD40LG, INS
15	cerebral malaria	26.7	SELE, IL10, IL1A, IFNG, TNF, NOS2
16	collagen disease	26.5	VWF, FGA, IL10, IL2RA, IFNG, TNF
17	arthropathy	26.4	BMP6, CHI3L1, CD79A, MMP2, IL10, IL2
18	urinary bladder cancer	26.1	RB1, NAT2, CDKN1A, CDKN2B, CDKN2A, GSTM1
19	filariasis	26.0	IL10, IL13, IL2, IL4, IL5, IL7
20	eosinophilia	25.8	CD79A, CD86, CD4, INS, IL10, IL13
21	dermatitis	25.2	SELE, NAT2, BCL2, LGMN, CHI3L1, CD79A
22	liver cirrhosis	25.2	SERPINC1, SERPINF2, CHI3L1, LCAT, GPT, IFNA2
23	disseminated intravascular coagulation	25.2	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, CD40LG
24	toxoplasmosis	24.7	BCL2, CD79A, CD4, CD40LG, IL10, IL4
25	papilloma	24.7	RB1, BCL2, CDKN1A, CDKN2B, CDKN2A, CD4
26	squamous cell carcinoma	23.0	RB1, NAT2, MYC, BMP6, BCL2, CDKN1A
27	vaginitis	21.8	SELE, SERPINC1, SERPINE1, BCL2, CD79A, MMP9
28	thrombocytopenia	21.5	VWF, SELE, SERPINC1, SERPINE1, BMP6, CD79A
29	bladder carcinoma	21.1	RB1, SELE, MYC, BMP6, BCL2, CDKN1A
30	viral hepatitis	20.8	SERPINC1, LCAT, CDKN1A, CDKN2A, CD40LG, INS
31	osteoporosis	20.8	SELE, SERPINC1, BMP6, CD79A, CD40LG, MMP9
32	fibrosis	16.8	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, NAT2
33	hypertension	15.3	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, BMP6
34	cerebritis	14.9	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, MYC
35	carcinoma	14.6	VWF, RB1, SELE, SERPINC1, SERPINF2, SERPINE1
36	allergic rhinitis	14.2	IL13, IL4, IL5, IGHE, RNASE3, EPX
37	cough variant asthma	14.2	IL10, IL4, IL5, IGHE, RNASE3
38	allergic conjunctivitis	14.2	IL13, IL4, IL5, IGHE, IFNG, RNASE3
39	cutaneous leishmaniasis	14.2	IL10, IL13, IL4, IL5, IFNG
40	kimura disease	14.2	IL13, IL4, IL5, IGHE, RNASE3
41	helminthiasis	14.2	IL13, IL5, IGHE, RNASE3
42	chronic sphenoidal sinusitis	14.1	IL13, IL4, IL5, IGHE, RNASE3
43	food allergy	14.1	IL13, IL4, IL5, IGHE, TXN, RNASE3
44	pulmonary eosinophilia	14.1	IL13, IL4, IL5, CCL3, IGHE, IFNG
45	intrinsic asthma	14.1	IL4, IL5, CCL5, IGHE, RNASE3
46	eosinophilic pneumonia	14.1	IL13, IL5, CCL5, IGHE, RNASE3
47	toxocariasis	14.1	CD40LG, IGHV4-39, IGHE, RNASE3
48	selective iga deficiency disease	14.0	CD79A, CD40LG, IL10, IL4
49	b cell deficiency	14.0	CD79A, IL4, IL5, IGHE
50	immunodeficiency with hyper igm type 1	14.0	CD79A, CD40LG, IL4, IGHE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 praziquantel

MalaCards organs/tissues related to schistosomiasis:

²²

MGI Mouse Phenotypes related to schistosomiasis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	STAT6, ELN, ALPL, CHRM2
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	CDKN2B, CD40LG, GUSB, IL2, IFNG, PHB2
3	craniofacial phenotype	MP:0005382	9.9	TGIF1, EDN1, ALPL, GUSB
4	hematopoietic system phenotype	MP:0005397	9.6	HLA-DQA1, HLA-DQB1, PNP, NLRP12, THPO, STAT6
5	renal/urinary system phenotype	MP:0005367	9.5	CDKN1A, CDKN2B, INS, IFNGR1, CTSB, PNP
6	liver/biliary system phenotype	MP:0005370	9.5	FGA, IL2, CCR5, IFNG, IFNGR1, TP53
7	embryogenesis phenotype	MP:0005380	9.4	ABCB7, EDN3, KRT18, TNFRSF1A, ALPP, ALPL
8	other phenotype	MP:0005395	9.2	TGIF1, ABCB7, NOS2, CTSB, TNFRSF1A, ALPL
9	reproductive system phenotype	MP:0005389	8.5	SCYL1, CDKN2B, MMP9, PHB2, TGFB1, TAGLN
10	pigmentation phenotype	MP:0001186	8.4	CP, EDN3, TP53, CCL2, FAS, CDKN2A
11	immune system phenotype	MP:0005387	8.2	IL2, CCND1, CCL3, IFNG, F2, ALPL
12	integument phenotype	MP:0010771	8.0	RB1, MYC, BCL2, CHRM2, CDKN1A, CDKN2B
13	behavior/neurological phenotype	MP:0005386	7.7	TNFRSF1A, HLA-DQB1, HMGB1, ALPL, F3, IFNGR1
14	adipose tissue phenotype	MP:0005375	6.7	ALPL, TP53, TNF, TNFRSF1A, PLAU, NOS2
15	mortality/aging	MP:0010768	6.6	VWF, RB1, SELE, SERPINC1, SERPINE1, CDKN1A
16	nervous system phenotype	MP:0003631	6.5	MMP2, ARG1, INS, FGA, CCND1, CCL3
17	digestive/alimentary phenotype	MP:0005381	6.4	VWF, RB1, MYC, BCL2, CDKN1A, CDKN2A
18	growth/size phenotype	MP:0005378	5.9	PHB2, KRT18, ABCB7, HBEGF, TAGLN, STAT6
19	vision/eye phenotype	MP:0005391	5.8	CDKN1A, TP53, TNF, TNFRSF1A, PLAU, NOS2
20	normal phenotype	MP:0002873	5.7	F3, F2, ALB, ALPP, HSPB1, HLA-DQB1
21	skeleton phenotype	MP:0005390	5.2	CCND1, IGF1, IFNGR1, ALPL, TP53, TNFRSF1A
22	muscle phenotype	MP:0005369	4.8	ALPL, HLA-DQB1, TP53, TNF, TNFRSF1A, PLAU
23	tumorigenesis	MP:0002006	4.5	RB1, SERPINE1, MYC, BCL2, IFNG, IFNGR1
24	cellular phenotype	MP:0005384	2.7	IL7, TXN, TP53, TNF, TNFRSF1A, TERT
25	cardiovascular system phenotype	MP:0005385	2.7	MAPK14, NOS2, EDN1, ABCB7, ELN, HBEGF
26	homeostasis/metabolism phenotype	MP:0005376	2.2	HBEGF, TGFB1, TGIF1, STAT6, NPPA, SLC17A5

Articles related to schistosomiasis:

(show top 50)    (show all 138)

id	Title	Authors	Year	Affiliating Genes
1	Platelet function and the von Willebrand factor antig en in the hepatosplenic form of schistosomiasis mansoni. (19118853)	Correia M.C.... Silva J.L.	2009	VWF
2	Possible role of telomerase and sFas in pathogenesis of various bladder lesions associated with schistosomiasis. (19272297)	Shaker O.G.... Wishahi M.	2009	TERT, FAS, SCYL1
3	DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. (18524429)	Da'dara A.A.... Harn D.A.	2008	HSPA8, TPI1, ROM1
4	Discriminating acute from chronic human schistosomiasis mansoni. (18851939)	Beck L.... Montenegro S.M.	2008	CD40LG
5	IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis. (18981143)	Herbert D.R.... Finkelman F.D.	2008	TGFB1
6	Recent advances in the characterization of genetic factors involved in human susceptibility to infection by schistosomiasis. (19471606)	Isnard A.... Chevillard C.	2008	IL4, IL13, IL9
7	Heat shock protein expression independently predicts survival outcome in schistosomiasis-associated urinary bladder cancer. (19199268)	El-Meghawry El-Kenawy A.... Hasan M.S.	2008	HSPB1
8	Genetic polymorphism of glutathione-S-transferase (GST-M1 and GST-T1) in schistosomiasis -associated bladder cancer in Egyptian patients. (19209780)	El Nouby K.A.... Ismail G.M.	2008	GSTT1, GSTM1
9	Eosinophil cationic protein, soluble egg antigen, circulating anodic antigen, and egg excretion in male urogenital schistosomiasis. (18784236)	Leutscher P.D.... A9rnbjerg N.	2008	RNASE3
10	Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. (18784223)	Erikstrup C.... Ullum H.	2008	IL10
11	Cytokine profile associated with chronic and acute human schistosomiasis mansoni. (18949326)	de Morais C.N.... Montenegro S.M.	2008	IL4, IFNG
12	A schistosomiasis research agenda. (18060081)	Colley D.G.... Secor W.E.	2007	IL13
13	Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. (16557547)	Kamal S.M.... Afdhal N.H.	2006	BMP6
14	Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans. (16428771)	Alves Oliveira L.F.... Correa-Oliveira R.	2006	TGFB1, IL13
15	INF-gamma, IL-5 and IgE profiles in chronic schistosomiasis mansoni Egyptian patients with or without hepatitis C infection. (16605110)	Makhlouf L.M.... Saad R.M.	2006	IL5
16	NAT2*5/*5 genotype (341T>C) is a potential risk factor for schistosomiasis-associated bladder cancer in Egyptians. (15905799)	El Desoky E.S.... Oellerich M.	2005	NAT2
17	Human T cell epitope mapping of the Schistosoma mansoni 14-kDa fatty acid-binding protein using cells from patients living in areas endemic for schistosomiasis. (15725385)	Fonseca C.T.... Oliveira S.C.	2005	IFNG, IL5, FABP12
18	Early post-treatment immunoglobulin profile in human schistosomiasis. (15881004)	Abd El-Aal A.A.... El-Badry A.A.	2005	CD40LG, CD79A, IGHE
19	The clinical significance of interferon-gamma and its receptor in patients with schistosomiasis (15830877)	Shao P.Y.... Huang Y.Y.	2004	IFNGR1, IFNG
20	Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. (15361241)	Dessein A.... Chevillard C.	2004	IFNG, IL13
21	Cell cycle regulators in bladder cancer: relationship to schistosomiasis. (15590562)	Eissa S.... El-Ahmady O.	2004	CCND1, CDKN1A, CDKN2A
22	Schistosomiasis co-infection in humans influences inflammatory markers in uncomplicated Plasmodium falciparum malaria. (15679634)	Diallo T.O.... Riveau G.	2004	IFNG, IL10, TGIF1
23	Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis: the asparaginyl endopeptidase (Sm32). (12941479)	Chacon N.... Noya O.	2003	LGMN
24	Assessment of eosinophil cationic protein as a possible diagnostic marker for female genital schistosomiasis in women living in a Schistosoma haematobium endemic area. (15053779)	Midzi N.... Mduluza T.	2003	RNASE3
25	Studies on the production and regulation of interleukin, IL-13, IL-4 and interferon-gamma in human Schistosomiasis mansoni. (12426605)	de Morais C.N.... Montenegro S.M.	2002	IL4, IFNG, IL13
26	Assessing the morbidity of schistosomiasis by measuring eosinophil cationic protein in serum. (12214929)	Hassan M.M.... el-Badrawy e.l.-.S.	2002	RNASE3
27	Genetic factors associated with development of cerebral malaria and fibrotic schistosomiasis. (12509099)	Hirayama K.	2002	TNF, IL13, HLA-DRB5
28	Schistosomiasis-induced IL-10 suppresses allergy prev alence. (11228005)	Taylor-Robinson A.	2001	IL10
29	Cellular immune responses of schistosomiasis patients are altered by human immunodeficiency virus type 1 coinfection. (11471107)	Mwinzi P.N.... Secor W.E.	2001	IL10
30	Community-based study of genital schistosomiasis in men from Madagascar. (10675174)	Leutscher P.... Vennervald B.J.	2000	RNASE3
31	CD4+ T cells of schistosomiasis naturally resistant individuals living in an endemic area produce interferon-gamma and tumour necrosis factor-alpha in response to the recombinant 14KDA Schistosoma mansoni fatty acid-binding protein. (10849370)	Brito C.F.... Oliveira S.C.	2000	IFNG, IL10, FABP12
32	Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasis. (10996125)	Stone P.J.	2000	ELN
33	Evidence for nitric oxide action on in vitro granuloma formation through pivotal changes in MIP-1alpha and IL-10 release in human schistosomiasis. (10369186)	Oliveira D.M.... Goes A.M.	1999	TNF, IL2, CCL2
34	Helminth- and Bacillus Calmette-GuAcrin-induced immunity in children sensitized in utero to filariasis and schistosomiasis. (10352306)	Malhotra I.... King C.L.	1999	IFNG
35	Study of gamma-interferon in schistosomiasis mansoni, autoimmune diseases and schistosomal arthropathy. (12561913)	Abdel-Aaty H.E.... Abdel-Rehim H.A.	1999	IFNG
36	Expression of bcl-2 and p53 oncoproteins in schistosomiasis-associated transitional and squamous cell carcinoma of urinary bladder. (9043502)	Chaudhary K.S.... Lalani E.N.	1997	TP53, BCL2
37	Diagnosis of female genital schistosomiasis by indirect disease markers: determination of eosinophil cationic protein, neopterin and IgA in vaginal fluid and swab eluates. (9028411)	Poggensee G.... Feldmeier H.	1996	CD79A, RNASE3
38	Evidence of a T helper type 2 activation in human schistosomiasis. (8647223)	AraA_jo M.I.... Carvalho E.M.	1996	IL4, IFNG, IL10
39	Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. (8648117)	King C.L.... Shata M.T.	1996	IFNG, IL10
40	Humoral immune responses in acute schistosomiasis mansoni: relation to morbidity. (8527552)	Rabello A.L.... Katz N.	1995	CD40LG
41	Detection of cellular and humoral markers (IL-2, IFN-gamma and IgE) in sera of patients with urinary schistosomiasis. (7665948)	Khalil H.M.... Abd el-Aziz S.S.	1995	IGHE
42	Disseminated intravascular coagulation in endemic hepatosplenic schistosomiasis. (7489960)	Omran S.A.... Mohamed A.A.	1995	F2, SERPINC1, F3
43	Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis. (7728097)	Badawi A.F.... O'Connor P.J.	1995	GUSB
44	Circulating enzyme activities of collagen turnover and undulin in patients with various degrees of schistosomiasis and alcoholic liver cirrhosis. (7782029)	Shahin M.... Seitz H.K.	1995	COL14A1
45	Is the coagulopathy of hepatosplenic schistosomiasis immune-related? (7865686)	Amer A.M.... el Khayat H.R.	1994	IL1A
46	O6-alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer. (7999420)	Badawi A.F.... O'Connor P.J.	1994	PPAT
47	The detection and significance of plasma atrial natriuretic peptide in advanced schistosomiasis patients (8112147)	Jiang Y.A.... Guan M.Y.	1993	NPPA
48	Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX). (8103623)	Reimert C.M.... Bendtzen K.	1993	EPX, RNASE3
49	Specific immunoglobulins in schistosomiasis. (2110218)	Khalil H.M.... Khalil N.M.	1990	CD40LG, CD79A
50	Serum type III procollagen peptides in patients with hepatointestinal and compensated hepatoesplenic schistosomiasis forms. (1978659)	Mincis M.... Juliano Y.	1990	ABCB7

Genes related to schistosomiasis according to GeneCards:

(show top 50)    (show all 125)

id	Symbol	Description	Score	GeneCards Section Context
1	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
2	IL13	interleukin 13	11.0	Publications
3	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
4	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
5	IL4	interleukin 4	11.0	Publications
6	IL10	interleukin 10	11.0	Publications
7	IFNG	interferon, gamma	11.0	Publications
8	COX6CP4	cytochrome c oxidase subunit VIc pseudogene 4	11.0
9	MRGPRE	MAS-related GPR, member E	11.0
10	MRGPRF	MAS-related GPR, member F	11.0
11	FABP12	fatty acid binding protein 12	11.0	Publications
12	EPX	eosinophil peroxidase	11.0	Publications
13	LGMN	legumain	11.0	Publications
14	TSPAN32	tetraspanin 32	11.0
15	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
16	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
17	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0	Publications
18	IFNGR1	interferon gamma receptor 1	11.0	Publications
19	CD40LG	CD40 ligand	11.0	Publications
20	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	11.0	Publications
21	IL7	interleukin 7	11.0
22	HSPA8	heat shock 70kDa protein 8	11.0	Publications
23	HMGB1	high mobility group box 1	11.0
24	GUSB	glucuronidase, beta	11.0	Publications
25	CD86	CD86 molecule	11.0
26	CTSB	cathepsin B	11.0
27	GSR	glutathione reductase	11.0
28	GSTM1	glutathione S-transferase mu 1	11.0	Publications
29	IL1A	interleukin 1, alpha	11.0	Publications
30	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0
31	IGHV4-39	immunoglobulin heavy variable 4-39	10.9
32	FBRS	fibrosin	10.9
33	CDC42SE1	CDC42 small effector 1	10.9	Disorders
34	EPGN	epithelial mitogen homolog (mouse)	10.9
35	SCYL1	SCY1-like 1 (S. cerevisiae)	10.9	Publications
36	ROM1	retinal outer segment membrane protein 1	10.9	Publications
37	AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	10.9
38	GSTA3	glutathione S-transferase alpha 3	10.9
39	TSPAN2	tetraspanin 2	10.9
40	TPI1	triosephosphate isomerase 1	10.9	Publications
41	IL9	interleukin 9	10.9	Publications
42	TAGLN	transgelin	10.9
43	GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	10.9
44	ARG1	arginase, liver	10.9	Publications
45	ALPPL2	alkaline phosphatase, placental-like 2	10.9
46	PPAT	phosphoribosyl pyrophosphate amidotransferase	10.9	Publications
47	PHB2	prohibitin 2	10.9	Publications
48	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	10.9	Publications
49	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	10.9	Publications
50	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	10.9	Publications

Pathways related to schistosomiasis according to GeneDecks:

(show top 50)    (show all 127)

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	10.4	IL5, IL4, IL13, IL9, BCL2
2	Graft-versus-host disease20	10.4	HLA-DQA1, HLA-DRB5, IL2, HLA-DPA1, IL1A, CD86
3	IL-6 Pathway36	10.3	IL9, IL7, CCL3, CCL5, PF4, IL5
4	Asthma20	10.3	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, TNF
5	Glutathione metabolism10	10.1	GGT1, GSTT1, GSTM1, GSTA4, GSTA3, GSTA1
6	Intestinal immune network for IgA production20	10.1	CD86, CD40LG, IL10, IL2, IL4, IL5
7	Cytokine Network36	10.0	IL9, IFNA2, IFNG, IL1A, IL2, IL4
8	Antigen processing and presentation20	10.0	HLA-DQB1, HLA-DPA1, HSPA8, LGMN, CTSB, HLA-DRB1
9	NFAT Signaling and Lymphocyte Interactions36	10.0	CCL3, BMP6, BCL2, CD4, IL13, IL1A
10	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	CCL3, IL2RA, IL2, TNFRSF1A, BCL2
11	Autoimmune thyroid disease20	9.8	IL10, IL2, IL4, IL5, FAS, IFNA2
12	Allograft rejection20	9.8	CD86, CD40LG, IL10, IL2, IL4, IL5
13	THC Differentiation Pathway36	9.8	CD86, IL10, IL2, IL2RA, IL4, IFNG
14	MIF Regulation of Innate Immune Cells36	9.8	PF4, TNF, CCL5, CCL3, CCL2, IL9
15	MIF Mediated Glucocorticoid Regulation36	9.7	IL9, IL7, IL5, IL4, IL2, IL1A
16	all-trans-Retinoic Acid Signaling in Brain36	9.7	IL13, IL1A, IL2, IL4, IL9, PF4
17	PEDF Induced Signaling36	9.7	PF4, TNF, CCL5, CCL3, CCL2, IL9
18	Rheumatoid arthritis20	9.7	IL1A, HLA-DQB1, HLA-DQA1, TGFB1, HLA-DPA1, IFNG
19	Endothelin-1 Signaling Pathway36	9.6	MYC, BMP6, IL10, IL13, IL1A, IL2
20	RAR-Gamma-RXR-Alpha Degradation36	9.6	PF4, CCL5, CCL3, IL2, MAPK14, IL9
21	ERK Signaling36	9.4	BMP6, IL4, IL2, IL1A, IL13, IL5
22	Regulation of eIF4 and p70S6K36	9.4	CD4, IL13, IL1A, IL4, CCL5, CCL3
23	Cytokine-cytokine receptor interaction20	9.3	IL1A, IL2, IL2RA, IL4, IL5, IL7
24	SOCS Pathway36	9.3	IL4, IL10, INS, CD4, BCL2, BMP6
25	Tec Kinases Signaling36	9.3	IL9, CCL2, CCR5, CCL3, CCL5, IGF1
26	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	IL2, TNF, TNFRSF1A, TGFB1, IL2RA, IL10
27	Akt Signaling36	9.3	CD4, IL10, IL2, IL2RA, IL4, IL7
28	Jak-STAT signaling pathway20	9.2	IL2, IL5, MYC, IL10, IL9, CCND1
29	Type I diabetes mellitus20	9.2	TNF, HLA-DRB5, HLA-DRB1, CD86, INS, IL1A
30	PGC1Alpha Pathway36	9.1	BCL2, CD4, IL13, IL1A, IL2, IL4
31	Rho Family GTPases36	9.1	CCL5, COL14A1, TGFB1, PF4, THPO, ELN
32	PAK Pathway36	9.1	PF4, BMP6, BCL2, IL10, IL13, IL2
33	Leishmaniasis20	8.9	MAPK14, IFNG, IFNGR1, HLA-DPA1, HLA-DQA1, HLA-DQB1
34	Antioxidant Action of Vitamin-C36	8.8	THPO, TGFB1, PF4, PPBP, TNFRSF1A, CCL5
35	Measles20	8.7	HSPA8, IFNGR1, IFNG, CCND1, TP53, FAS
36	Influenza A20	8.6	FAS, MAPK14, TNF, IL1A, TNFRSF1A, HLA-DRB5
37	Glucocorticoid Receptor Signaling36	8.6	BMP6, BCL2, CDKN1A, CD4, IL10, IL13
38	Toxoplasmosis20	8.5	HSPA8, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5
39	Immune response IL-22 signaling pathway10	8.4	HLA-DRB1, HLA-DPA1, IL2RA, IL2, HLA-DQA1, HLA-DRB5
40	TGF-Beta Pathway36	8.4	BMP6, BCL2, CD4, IL10, IL13, IL1A
41	Immune response_IL-22 signaling pathway41	8.3	HLA-DQB1, MYC, MAPK14, BCL2, CD86, IL2
42	JAK-STAT Pathway36	8.3	MYC, BMP6, BCL2, CD4, IL10, IL13
43	Tuberculosis20	8.2	IL10, TGFB1, IFNG, IFNA2, MAPK14, IL1A
44	Chagas disease (American trypanosomiasis)20	8.2	TNFRSF1A, NOS2, IFNG, TNF, CCL5, CCL3
45	MAPK Family Pathway36	8.0	IGF1, HSPB1, TNF, TNFRSF1A, PPBP, THPO
46	NFAT in Immune Response36	8.0	IL9, CD86, CD79A, TGFB1, BMP6, IL2
47	Molecular Mechanisms of Cancer36	7.9	TP53, CCL5, CCND1, IL9, IL7, IL5
48	STAT3 Pathway36	7.8	CCR5, CCL3, CCL5, TNF, TNFRSF1A, PF4
49	p38 Signaling36	7.6	CCR5, CCL2, MAPK14, IL9, IL7, IL5
50	Pancreatic Adenocarcinoma36	7.3	CCND1, IL9, BMP6, RB1, CDKN2B, CDKN2A

Compounds related to schistosomiasis according to GeneDecks:

(show top 50)    (show all 493)

id	Compound	Score	Top Affiliating Genes
1	allergens32	10.7	CD79A, CD86, CD40LG, IL10, IL13, IL4
2	sp 60012532 42	11.3	CDKN1A, IL13, TP53
3	ivig32	10.3	VWF, CCR5, CRP, ELN
4	sodium nitroprusside32	10.2	VWF, BMP6, IL13, IL5, HSPA8, EDN3
5	nicotine32 34 9 9	13.2	RB1, GPT, SLC17A5
6	tarc32	9.8	CD4, IL10, IL13, IL1A, IL4, IL5
7	pge132	9.7	VWF, SERPINE1, LCAT, FGA, IL1A, GPT
8	agar32	9.7	RB1, CDKN2A, CD40LG, IL7, IL9, CCND1
9	rapamycin32 42	10.4	RB1, CD86, INS, IL2, CCR5, IFNG
10	polysaccharide32	9.3	SELE, SERPINC1, SERPINF2, BMP6, CD79A, CD4
11	h2o232	9.3	VWF, CD79A, IL13, IL2RA, IL5, MAPK14
12	chloroquine32 34 9 9	12.2	SERPINC1, BMP6, CD79A, CD4, GSR, GSTA2
13	mannitol32 9 9	11.2	CD40LG, GUSB, MAPK14, IGHE, IFNA2, HSPB1
14	betacarotene32	9.1	VWF, RB1, NAT2, CD79A, GSR, GSTM1
15	il 1032	9.0	BMP6, IL10, IL13, IL1A, IL2, IL2RA
16	dopamine32 9 18 9	11.8	SELE, BMP6, CD79A, CDKN2A, CD40LG, MMP9
17	okt332	8.8	SELE, BMP6, CD79A, CD40LG, IL10, IL2
18	sodium dodecylsulfate32	8.7	VWF, SERPINF2, SERPINE1, MYC, BMP6, LCAT
19	ribavirin32 34 9 9	11.7	CD40LG, MMP2, MMP9, IL10, IL2, IL4
20	neopterin32	8.7	CD79A, CD4, CD40LG, IL10, IL1A, IL2
21	formaldehyde32 18	9.4	VWF, RB1, SELE, CD79A, CD4, CD40LG
22	4-hydroxynonenal32 18	9.3	MYC, LCAT, GUSB, GSR, GSTA4, GSTM1
23	vitamin a32 9 18 9	11.3	VWF, RB1, NAT2, MYC, LCAT, GSR
24	superoxide32 18	9.2	RB1, GUSB, GSR, FABP12, MAPK14, CCL2
25	prostacyclin32	8.2	VWF, SELE, SERPINC1, SERPINE1, BMP6, FGA
26	epinephrine32 9 18 9	11.1	SELE, SERPINF2, BMP6, CD79A, MMP2, MMP9
27	etoposide32 42 9 9	11.1	RB1, SELE, MYC, BCL2, CDKN1A, MMP2
28	5fluorouracil32	8.0	RB1, SELE, BCL2, CDKN1A, CDKN2A, MMP2
29	cysteine32	8.0	NAT2, LGMN, LCAT, CD79A, CDKN2A, CD4
30	retinoid32	7.9	MYC, BMP6, CDKN1A, FABP12, MAPK14, CCND1
31	testosterone32 9 18 9	10.8	RB1, SELE, SERPINC1, SERPINF2, LCAT, CD79A
32	tacrolimus32 34 9 9	10.8	SERPINE1, MYC, BMP6, CD79A, CD86, INS
33	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	7.7	MYC, BCL2, MMP2, MMP9, IL1A, IL7
34	triptolide32	7.7	BCL2, CD86, IL2, MAPK14, CCL2, CCL3
35	prednisolone32 9 9	9.6	VWF, MYC, BMP6, CD79A, MMP2, GSTM1
36	adenylate32	7.4	VWF, SELE, SERPINC1, SERPINE1, CHRM2, CD40LG
37	ly29400232	7.2	SELE, MMP2, MMP9, IL10, IL13, IL4
38	cholesterol32 9 18 9	10.2	VWF, RB1, SELE, SERPINF2, SERPINE1, NAT2
39	tamoxifen32 34 9 9	10.2	SELE, SERPINC1, MYC, BMP6, BCL2, CDKN1A
40	folate32	7.1	VWF, SELE, SERPINC1, NAT2, MYC, CD79A
41	arsenite32 18	7.6	MYC, BCL2, CDKN1A, CDKN2B, CDKN2A, MMP9
42	paraffin32	6.4	VWF, RB1, MYC, BCL2, CD79A, CDKN1A
43	herbimycin a32 42	7.3	SELE, MYC, BMP6, CD4, CD40LG, MMP2
44	lactate32	6.3	VWF, SELE, BMP6, CD79A, CD40LG, MMP2
45	sb 20358032 42	7.3	RB1, SELE, BMP6, BCL2, CDKN1A, MMP2
46	alanine32	5.6	VWF, SELE, SERPINC1, SERPINF2, MYC, BMP6
47	phosphatidylinositol32	5.4	RB1, MYC, BMP6, BCL2, SCYL1, CHRM2
48	pd 98,05932	5.4	RB1, SERPINE1, MYC, BMP6, BCL2, CDKN1A
49	vegf32	5.3	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, MYC
50	actinomycin d32	4.6	RB1, SELE, SERPINE1, MYC, BCL2, CDKN1A

Cellular components related to schistosomiasis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.2	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
2	clathrin-coated endocytic vesicle membrane	GO:030669	10.2	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
4	ER to Golgi transport vesicle membrane	GO:012507	10.1	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5
5	trans-Golgi network membrane	GO:032588	10.0	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
6	transport vesicle membrane	GO:030658	9.8	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
7	external side of plasma membrane	GO:009897	9.7	CCR5, IFNG, HLA-DRB1, HLA-DRB5, TNF, CTSB
8	cell surface	GO:009986	9.6	TGFB1, HBEGF, PLAU, TNFRSF1A, TNF, HMGB1
9	platelet alpha granule lumen	GO:031093	9.5	TGFB1, PF4, PPBP, ALB, IGF1, FGA
10	cytosol	GO:005829	6.8	CCND1, CCL3, GPT, HSPB1, HSPA8, TXN
11	extracellular region	GO:005576	5.7	IL13, IL1A, IL2, IL5, IL7, FAS
12	extracellular space	GO:005615	5.5	THPO, TGFB1, CP, HBEGF, SELE, FGA

Biological processes related to schistosomiasis according to GeneDecks:

(show all 48)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MHC class II biosynthetic process	GO:045348	10.8	IFNG, IL4, IL10, CD40LG
2	glutathione metabolic process	GO:006749	10.5	GGT1, GSTT1, GSTA4, GSTA3, GSTA2, GSTA1
3	B cell proliferation	GO:042100	10.5	IL10, CD40LG, CD79A, BCL2
4	response to cholesterol	GO:070723	10.5	CCR5, CCL3, CCL5, TGFB1
5	interferon-gamma-mediated signaling pathway	GO:060333	10.4	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IFNGR1
6	positive regulation of B cell proliferation	GO:030890	10.3	IL7, IL5, IL4, IL2, IL13, CD40LG
7	T cell costimulation	GO:031295	10.2	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, CD4
8	cellular response to lipopolysaccharide	GO:071222	10.2	NOS2, IFNG, CCR5, CCL2, IL10, ARG1
9	neutrophil chemotaxis	GO:030593	10.1	EDN3, EDN1, IFNG, CCL3, CCL2
10	cellular response to organic cyclic compound	GO:071407	10.1	TGFB1, TNF, ALPL, CCL5, CCL3, CCL2
11	cellular response to interferon-gamma	GO:071346	10.1	NOS2, HLA-DPA1, CCL5, CCL3, CCL2
12	protein kinase B signaling cascade	GO:043491	10.0	TGFB1, TNF, CCL5, CCL3, CCL2
13	cytokine-mediated signaling pathway	GO:019221	10.0	HLA-DQB1, HLA-DRB1, HLA-DRB5, TNFRSF1A, PF4, HLA-DQA1
14	response to glucocorticoid stimulus	GO:051384	10.0	TAT, TNF, HMGB1, ALPL, CCL5, CCL2
15	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	HBEGF, EDN1, TNF, IGF1, CCL5, IL13
16	neuron apoptotic process	GO:051402	9.8	GAPDH, TP53, FAS, BCL2, RB1
17	immune response	GO:006955	9.8	BMP6, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5
18	cellular response to interleukin-1	GO:071347	9.7	EDN1, CCL5, CCL3, CCL2, MMP9, CHI3L1
19	positive regulation of angiogenesis	GO:045766	9.7	TNFRSF1A, F3, CCL5, IL1A, MMP9, CHI3L1
20	platelet degranulation	GO:002576	9.7	TGFB1, PF4, PPBP, ALB, IGF1, FGA
21	replicative senescence	GO:090399	9.7	TERT, TP53, CDKN2A, CDKN1A
22	response to mechanical stimulus	GO:009612	9.7	CTSB, TNF, F3, CCL2, MMP9, CHI3L1
23	positive regulation of smooth muscle cell migration	GO:014911	9.6	F3, IGF1, CCL5, BCL2
24	chemotaxis	GO:006935	9.6	PLAU, PPBP, CCL5, CCL3, CCR5, CCL2
25	response to ethanol	GO:045471	9.5	CTSB, TNFRSF1A, GOT2, CCND1, CCL2, IL4
26	response to gamma radiation	GO:010332	9.5	TP53, CCL2, IL1A, BCL2, MYC
27	cell-cell signaling	GO:007267	9.5	CCL5, IFNA2, TXN, EDN1, EDN3, TSPAN32
28	response to lipopolysaccharide	GO:032496	9.5	THPO, EDN1, TNFRSF1A, ALPL, F3, FAS
29	positive regulation of mitosis	GO:045840	9.4	EPGN, EDN3, EDN1, TNF, IGF1, IL1A
30	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	TGFB1, TNF, CCL5, CCL3, CCL2, MAPK14
31	positive regulation of cell migration	GO:030335	9.3	HBEGF, EDN1, F3, CCL5, CCL3, INS
32	inflammatory response	GO:006954	9.3	CCR5, CCL3, CCL5, IFNA2, TNF, TNFRSF1A
33	positive regulation of protein kinase B signaling cascade	GO:051897	9.3	TGFB1, HBEGF, TNF, F3, IGF1, CCL3
34	positive regulation of cell growth	GO:030307	9.3	HBEGF, F2, IL9, IL2, INS, BCL2
35	negative regulation of gene expression	GO:010629	9.2	NOS2, TNFRSF1A, TNF, IFNA2, CCL3, CDKN1A
36	small molecule metabolic process	GO:044281	9.1	GPT, GOT2, ALB, TXN, TPI1, PPAT
37	MAPK cascade	GO:000165	9.1	TGFB1, TNF, CCL5, CCL3, CCR5, CCL2
38	anti-apoptosis	GO:006916	9.1	IGF1, F3, HSPB1, TNF, TERT, CCL2
39	cell surface receptor signaling pathway	GO:007166	9.0	EDN3, EDN1, F2, IFNG, IFNA2, CCR5
40	cell cycle arrest	GO:007050	9.0	TGFB1, TP53, IFNG, CDKN2A, CDKN2B, CDKN1A
41	platelet activation	GO:030168	8.7	TGFB1, THPO, PF4, PPBP, ALB, F2
42	positive regulation of cell proliferation	GO:008284	8.5	EPGN, TGFB1, THPO, EDN3, EDN1, F2
43	negative regulation of apoptotic process	GO:043066	8.2	HSPB1, TP53, TNF, PF4, KRT18, ALB
44	response to hypoxia	GO:001666	8.2	TGFB1, EDN1, NOS2, CRP, TNFRSF1A, TNF
45	glucose metabolic process	GO:006006	8.0	GAPDH, TNF, TPI1, GOT2, MAPK14, INS
46	response to drug	GO:042493	7.9	CCL5, IFNG, TNF, PNP, EDN1, TGFB1
47	blood coagulation	GO:007596	7.3	ALB, TP53, PPBP, PLAU, NOS2, PF4
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.3	MAPK14, IGF1, IFNG, HMGB1, TP53, TNF

Molecular functions related to schistosomiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.1	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
2	glutathione transferase activity	GO:004364	9.9	GSTT1, GSTM1, GSTA4, GSTA3, GSTA2, GSTA1
3	cytokine activity	GO:005125	9.5	BMP6, THPO, EDN1, TNF, HMGB1, IFNG
4	growth factor activity	GO:008083	9.3	F2, PPBP, HBEGF, THPO, TGFB1, EPGN
5	protease binding	GO:002020	8.7	TNFRSF1A, TNF, TP53, F3, INS, BCL2
6	protein binding	GO:005515	1.7	TNFRSF1A, TNF, TP53, TXN, HMGB1, HSPA8