MCID: SCH012
MIFTS: 54

Schizoaffective Disorder malady

Neuronal category

Summaries for Schizoaffective Disorder

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.

MalaCards: Schizoaffective Disorder is related to bipolar disorder and bipolar i disorder. An important gene associated with Schizoaffective Disorder is DISC1 (disrupted in schizophrenia 1), and among its related pathways are GPCRs, Other and Dopamine receptors. The compounds pergolide and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:64 Schizoaffective disorder (abbreviated as SZA or SAD) is a mental disorder characterized by disordered... more...

Description from OMIM:47 181500

Aliases & Classifications for Schizoaffective Disorder

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

schizoaffective disorder 8 47 10 45 61


External Ids:

Disease Ontology8 DOID:5418
ICD9CM27 295.7
MeSH35 D011618
ICD1025 F25, F25.9

Related Diseases for Schizoaffective Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Schizoaffective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.4SLC6A4, BDNF
2bipolar i disorder30.9DTNBP1
3obsessive-compulsive disorder30.6SLC6A4, DRD4, DRD3, DRD2, HTR2A, BDNF
4anxiety disorder30.5COMT, BDNF, HTR2A, DRD2, CYP2D6, SLC6A4
5substance abuse30.0DRD2, DRD3, DRD4, SLC6A4
6alcohol dependence30.0SLC6A4, DRD4, DRD2, HTR2A
7cocaine dependence30.0SLC6A4, DRD3, DRD2
8pathological gambling30.0DRD4, DRD3, DRD2
9parkinson's disease30.0COMT, BDNF, DRD2, DRD3, CYP2D7P1, CYP2D6
10hyperprolinemia30.0PRODH
11schizophreniform disorder10.5
12prolactinoma10.2
13adjustment disorder10.2
14wernicke-korsakoff syndrome10.0
15dependent personality disorder10.0
16schizotypal personality disorder10.0
17hepatitis d10.0
18acute porphyria10.0
19amnestic disorder10.0
20basal cell carcinoma10.0
21sleep disorder10.0
22thrombocytopenia10.0
23withdrawal disorder10.0
24tardive dyskinesia10.0
25mass syndrome10.0
26cardiovascular disease risk factor10.0
27hypoxia10.0
28schizophrenia 1210.0
29memory impairment10.0
30leukopenia10.0
31argyria10.0
32early-onset schizophrenia10.0
33restless legs syndrome10.0DRD2
34heroin dependence10.0DRD2, DRD4
35panic disorder10.0SLC6A4, DRD4, HTR2A, COMT
36borderline personality disorder10.0SLC6A4
37dementia10.0COMT, BDNF, HTR2A, CYP2D6, NOS1
38chronic fatigue syndrome10.0SLC6A4
39fibromyalgia10.0SLC6A4, HTR2A, COMT
40antisocial personality disorder10.0HTR2A, DRD2, SLC6A4
41schizophrenia10.0COMT, HTR2A, DRD3, DISC1
42nicotine dependence10.0DRD2, DRD4, SLC6A4
43bulimia nervosa10.0COMT, BDNF, HTR2A, SLC6A4
44alcohol abuse10.0COMT, DRD2, DRD3, SLC6A4
45substance dependence10.0SLC6A4, DRD4, DRD3, DRD2, COMT
46migraine10.0NOTCH4, SLC6A4, CYP2D6, DRD4, DRD3, DRD2
47hypertension10.0SLC6A4
48seasonal affective disorder10.0HTR2A, DRD4, SLC6A4
49mood disorder10.0NOS1, SLC6A4, DISC1, DRD4, DRD3, DRD2
50drug dependence10.0SLC6A4, DRD3, DRD2

Graphical network of the top 20 diseases related to Schizoaffective Disorder:



Diseases related to schizoaffective disorder

Clinical Features for Schizoaffective Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

181500

Drugs & Therapeutics for Schizoaffective Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Schizoaffective Disorder

Drug clinical trials:

Search ClinicalTrials for Schizoaffective Disorder

Search NIH Clinical Center for Schizoaffective Disorder

Search CenterWatch for Schizoaffective Disorder

Genetic Tests for Schizoaffective Disorder

Anatomical Context for Schizoaffective Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Schizoaffective Disorder:

33
Brain, Cortex, T cells, B cells, Fetal brain, Prefrontal cortex

Animal Models for Schizoaffective Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Schizoaffective Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.4DTNBP1, BDNF, DRD2, DRD3, DRD4, DISC1
2MP:000538610.3NOS1, COMT, DTNBP1, BDNF, HTR2A, DRD2
3MP:000363110.1DRD4, DRD3, DRD2, BDNF, COMT, DISC1

Publications for Schizoaffective Disorder

Sources:
51PubMed
See all sources

Articles related to Schizoaffective Disorder:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Making up schizoaffective disorder: cosmetic changes to a sad creation? (24072567)
2013
2
Treatment adherence in bipolar I and schizoaffective disorder, bipolar type. (24099884)
2013
3
Heterogeneity of schizoaffective disorder compared with schizophrenia and bipolar disorder. (23465195)
2013
4
Reduction in tonal discriminations predicts receptive emotion processing deficits in schizophrenia and schizoaffective disorder. (21725063)
2013
5
Is schizoaffective disorder still a neglected condition in the scientific literature? (23007654)
2012
6
Diagnostic specificity of poor premorbid adjustment: comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features. (22858353)
2012
7
31P-MR spectroscopy in monozygotic twins discordant for schizophrenia or schizoaffective disorder. (22051037)
2012
8
Schizoaffective disorder--an ongoing challenge for psychiatric nosology. (20646917)
2011
9
Neurocognition in early-onset schizophrenia and schizoaffective disorders. (20215926)
2010
10
Frequency of schizoaffective disorder in an International patient population with psychotic disorders using the Mini-International Neuropsychiatric Interview. (20189355)
2010
11
Effects of high-dose ziprasidone and haloperidol on the QTc interval after intramuscular administration: a randomized, single-blind, parallel-group study in patients with schizophrenia or schizoaffective disorder. (20399985)
2010
12
Remission in schizophrenia: one-year Italian prospective study of risperidone long-acting injectable (RLAI) in patients with schizophrenia or schizoaffective disorder. (19790173)
2009
13
Switching to aripiprazole from olanzapine leads to weight loss in overweight people with schizophrenia or schizoaffective disorder. (19395609)
2009
14
Is schizoaffective disorder a useful diagnosis? (19635243)
2009
15
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
16
Does schizoaffective disorder really exist? A systematic review of the studies that compared schizoaffective disorder with schizophrenia or mood disorders. (17719092)
2008
17
Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study. (18312044)
2008
18
A multicenter, randomized, double-blind study of the effects of aripiprazole in overweight subjects with schizophrenia or schizoaffective disorder switched from olanzapine. (18605811)
2008
19
Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial. (17625502)
2008
20
Comparative psychometric properties of the BACS and RBANS in patients with schizophrenia and schizoaffective disorder. (18790606)
2008
21
Standard and higher dose of olanzapine in patients with schizophrenia or schizoaffective disorder: a randomized, double-blind, fixed-dose study. (18626265)
2008
22
Comparison of ziprasidone and aripiprazole in acutely ill patients with schizophrenia or schizoaffective disorder: a randomized, double-blind, 4-week study. (17917555)
2007
23
Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder. (17388704)
2007
24
Effectiveness, tolerability, and safety of ziprasidone in patients with schizophrenia or schizoaffective disorder: results of a multi-centre observational trial. (17140769)
2007
25
Prevalence and clinical characteristics of obsessive-compulsive disorder and obsessive compulsive symptoms in Afrikaner schizophrenia and schizoaffective disorder patients. (19588030)
2007
26
Sexual dysfunction associated with second-generation antipsychotics in outpatients with schizophrenia or schizoaffective disorder: an empirical evaluation of olanzapine, risperidone, and quetiapine. (16730951)
2006
27
Differing correlates for suicide attempts among patients with schizophrenia or schizoaffective disorder in India and USA. (16781121)
2006
28
Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. (15504429)
2005
29
A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. (15940305)
2005
30
Mood disorder with psychotic features, schizoaffective disorder, and schizophrenia with mood features: trouble at the borders. (16194767)
2005
31
Aripiprazole is effective against the symptoms of schizophrenia and schizoaffective disorder. (14769657)
2004
32
Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: retrospective case studies. (15520608)
2004
33
Randomized, controlled, double-blind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. (14615877)
2004
34
Baclofen as adjunctive treatment for a patient with cocaine dependence and schizoaffective disorder. (15349029)
2004
35
Prophylaxis of schizoaffective disorder with lithium or carbamazepine: outcome after long-term follow-up. (15023479)
2004
36
Clozapine: in prevention of suicide in patients with schizophrenia or schizoaffective disorder. (12665398)
2003
37
Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. (12650958)
2003
38
Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: an in vivo 31P MRS study. (12660804)
2003
39
EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder. (14638599)
2003
40
Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. (12140115)
2002
41
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. (12042192)
2002
42
Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study. (12478881)
2002
43
Ziprasidone in the short-term treatment of patients with schizoaffective disorder: results from two double- blind, placebo-controlled, multicenter studies. (11199944)
2001
44
"Internet delusion" in a patient with a schizoaffective disorder. (11221500)
2001
45
Schizophrenia and schizoaffective disorder treated with high doses of olanzapine. (10350037)
1999
46
An overview of the treatment of schizoaffective disorder. (10192403)
1999
47
Olanzapine versus haloperidol in the treatment of schizoaffective disorder. Acute and long-term therapy. (10211146)
1999
48
Therapeutic window of serum haloperidol concentration in acute schizophrenia and schizoaffective disorder. (9832347)
1998
49
Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. (9619160)
1998
50
The prevalence of comorbid anxiety in schizophrenia, schizoaffective disorder and bipolar disorder. (9565185)
1998

Genetic Variations for Schizoaffective Disorder

Expression for genes affiliated with Schizoaffective Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Schizoaffective Disorder

Search GEO for disease gene expression data for Schizoaffective Disorder.

Pathways for genes affiliated with Schizoaffective Disorder

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 52QIAGEN, 30KEGG, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Schizoaffective Disorder

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1pergolide29 45 1112.9CYP2D6, COMT, HTR2A, DRD2, DRD3, DRD4
2remoxipride45 1111.9DRD4, PRL, CYP2D6, DRD3, DRD2, HTR2A
3olanzapine50 45 29 11 2414.9COMT, BDNF, HTR2A, DRD2, DRD3, DRD4
4pramipexole45 50 29 1113.9COMT, HTR2A, DRD2, BDNF, DRD3, DRD4
5ropinirole45 1111.8DRD3, COMT, HTR2A, DRD2, DRD4, CYP2D6
6haloperidol45 29 2 50 1114.8CYP2D6, PRL, DRD4, DRD3, DRD2, HTR2A
7lisuride29 45 1112.8DRD4, DRD3, DRD2, PRL, CYP2D6, HTR2A
8paroxetine45 50 29 1113.8COMT, BDNF, SLC6A4, CYP2D6, PRL, DRD4
9quetiapine45 50 29 11 2414.8BDNF, PRL, HTR2A, DRD2, DRD3, DRD4
10maoa4510.8DRD4, SLC6A4, COMT, DRD2, BDNF, HTR2A
11iloperidone50 45 29 1113.8NRG3, DRD4, HTR2A, DRD2, DRD3, CYP2D6
12paliperidone45 1111.8DRD2, HTR2A, CYP2D6, DRD4, PRL, DRD3
13methamphetamine45 50 1112.8NOS1, SLC6A4, CYP2D6, DRD4, DRD3, DRD2
14chlorpromazine45 29 50 1113.8BDNF, CYP2D6, PRL, DRD3, DRD2, DRD4
15risperidone29 45 50 60 11 2415.8CYP2D6, DRD3, DRD2, HTR2A, BDNF, COMT
16cabergoline29 45 1112.8DRD3, PRL, DRD4, COMT, DRD2, HTR2A
17aripiprazole29 50 45 11 2414.8DRD4, HTR2A, DRD2, DRD3, PRL, CYP2D6
18clozapine45 29 50 1113.8DRD2, DRD3, DTNBP1, BDNF, HTR2A, DRD4
19fluoxetine50 45 29 1113.8BDNF, DRD2, PRL, CYP2D6, NOS1, SLC6A4
20ziprasidone50 29 45 1113.8CYP2D6, PRL, DRD4, DRD3, HTR2A, DRD2
21cocaine45 1111.8BDNF, COMT, DRD3, DRD4, PRL, CYP2D6
22apomorphine45 29 1112.8DRD4, DRD3, DRD2, HTR2A, PRL, COMT
23dopamine45 29 11 2413.8NOS1, SLC6A4, CYP2D6, PRL, DISC1, DRD4
24terguride29 4511.8DRD4, HTR2A, DRD3, DRD2, PRL
25fluphenazine29 45 1112.8CYP2D6, PRL, DRD2, HTR2A, DRD4
26amoxapine45 29 1112.8CYP2D6, HTR2A, DRD2, PRL, SLC6A4
27piperazine45 1111.8DRD2, DRD4, DRD3, HTR2A, CYP2D6
28levodopa45 1111.8CYP2D6, PRL, DRD2, DRD4, DRD3, BDNF
29norepinephrine45 11 2412.8BDNF, HTR2A, NOS1, DRD2, DRD3, DRD4
30bromocriptine29 45 1112.8HTR2A, DRD2, COMT, DRD4, DRD3, PRL
31mhpg4510.8DRD4, PRL, COMT, SLC6A4, BDNF
32pimozide29 50 45 1113.8HTR2A, PRL, DRD2, CYP2D6, DRD3
33trimipramine50 45 1112.8PRL, SLC6A4, HTR2A, DRD2, CYP2D6
34methylphenidate45 50 1112.8DRD2, CYP2D6, SLC6A4, COMT, DRD4
35amisulpride45 29 1112.7PRL, HTR2A, DRD2, DRD3
36Methotrimeprazine1110.7HTR2A, DRD2, DRD3, CYP2D6, DRD4
37mptp4510.7DRD3, DRD2, COMT, NOS1, BDNF, SLC6A4
385-hydroxytryptamine4510.7HTR2A, PRL, DRD4, DRD2, COMT, NOS1
39imipramine45 50 29 11 2414.7SLC6A4, NOS1, DRD3, HTR2A, BDNF, CYP2D6
40asenapine29 1111.7HTR2A, DRD2, DRD3, DRD4, CYP2D6
41nemonapride50 45 2912.7DRD3, DRD4, PRL, DRD2
42heroin45 50 1112.6COMT, DRD2, DRD3, DRD4, SLC6A4
43(+)-butaclamol29 4511.6DRD2, DRD4, DRD3, HTR2A
44nicotine45 50 29 1113.6DRD3, CYP2D6, NOS1, SLC6A4, DRD4, DRD2
45bupropion45 50 11 2413.5COMT, DRD3, CYP2D6, SLC6A4, DRD2
46mcpp4510.5SLC6A4, CYP2D6, PRL, HTR2A
47flupenthixol45 50 1112.4PRL, HTR2A, DRD2, CYP2D6
48rotigotine45 29 1112.4CYP2D6, DRD4, DRD2, DRD3
49minaprine45 1111.3SLC6A4, CYP2D6, DRD2, HTR2A
50duloxetine45 50 29 1113.1HTR2A, SLC6A4, CYP2D6, DRD3

GO Terms for genes affiliated with Schizoaffective Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic densityGO:01406910.5DISC1, DRD2, DTNBP1
2dendritic spineGO:04319710.3NOS1, DRD4, DRD2, DTNBP1
3integral to plasma membraneGO:00588710.1HTR2A, DRD2, DRD3, DRD4, NRG3, PCDH11X

Biological processes related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.8DRD3, DRD2, HTR2A, DTNBP1
2response to histamineGO:03477610.8DRD2, DRD3, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD4, DRD3, DRD2
4dopamine metabolic processGO:04241710.8DRD2, DRD3, DRD4
5negative regulation of protein secretionGO:05070910.8DRD2, DRD3, DRD4
6behavioral response to cocaineGO:04814810.8DRD2, DRD3, DRD4
7synaptic transmission, dopaminergicGO:00196310.8DRD2, DRD3, DRD4
8arachidonic acid secretionGO:05048210.8DRD4, DRD3, DRD2
9response to drugGO:04249310.8COMT, HTR2A, DRD2, DRD3, PRL, SLC6A4
10cellular calcium ion homeostasisGO:00687410.8HTR2A, DRD2, DRD3, DRD4
11negative regulation of adenylate cyclase activityGO:00719410.8DRD4, DRD3, DRD2
12negative regulation of blood pressureGO:04577610.8NOS1, DRD3, DRD2
13response to amphetamineGO:00197510.8DRD2, DRD3, DRD4
14negative regulation of voltage-gated calcium channel activityGO:190138610.8DRD2, DRD4
15social behaviorGO:03517610.8SLC6A4, DRD4, DRD3
16negative regulation of dopamine receptor signaling pathwayGO:06016010.8DRD2, DRD3
17positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.8DRD2, DRD4
18regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
19response to hypoxiaGO:00166610.7BDNF, DRD2, SLC6A4, NOS1
20regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
21circadian rhythmGO:00762310.7SLC6A4, PRL, EGR3
22multicellular organismal response to stressGO:03355510.7NOS1, PRL
23behavioral response to ethanolGO:04814910.7DRD4, DRD2
24negative regulation of synaptic transmission, glutamatergicGO:05196710.6DRD2, HTR2A
25negative regulation of potassium ion transportGO:04326710.6HTR2A, NOS1
26G-protein coupled receptor internalizationGO:00203110.6DRD2, DRD3
27prepulse inhibitionGO:06013410.5DRD3, DRD2
28temperature homeostasisGO:00165910.5DRD2, HTR2A
29positive regulation of renal sodium excretionGO:03581510.5DRD2, DRD3
30circadian regulation of gene expressionGO:03292210.4DRD2, DRD3
31neurotransmitter biosynthetic processGO:04213610.2NOS1, COMT

Molecular functions related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5DRD4, DRD3, DRD2
2drug bindingGO:00814410.3CYP2D6, DRD4, DRD3, DRD2, HTR2A
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.2DRD2, DRD3, DRD4

Products for genes affiliated with Schizoaffective Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Schizoaffective Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet