MCID: SCH012
MIFTS: 54

Schizoaffective Disorder malady

Mental diseases category
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Summaries for Schizoaffective Disorder

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.

MalaCards: Schizoaffective Disorder is related to schizophrenia and bipolar disorder. An important gene associated with Schizoaffective Disorder is DISC1 (disrupted in schizophrenia 1), and among its related pathways are ErbB4 signaling events and Nuclear signaling by ERBB4. The compounds (+)-sulpiride and (-)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include testes, cortex and prefrontal cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:65 Schizoaffective disorder (abbreviated as SZA or SAD) is a mental disorder characterized by abnormal... more...

Description from OMIM:47 181500

Aliases & Classifications for Schizoaffective Disorder

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Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

schizoaffective disorder 8 47 10 45 62


External Ids:

Disease Ontology8 DOID:5418
ICD9CM27 295.7
MeSH35 D011618
ICD1025 F25, F25.9

Related Diseases for Schizoaffective Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Schizoaffective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia32.0DRD3, HTR2A, DISC1
2bipolar disorder31.1HTR2A, DRD2
3obesity30.5DRD2, DRD4, HTR2A
4mood disorder30.5DISC1, HTR2A, DRD4, DRD3, DRD2
5obsessive-compulsive disorder30.3DRD2, DRD3, DRD4, HTR2A
6prolactinoma30.3DRD2, PRL
7parkinson's disease30.1DRD2, DRD3
8cocaine dependence30.1DRD3, DRD2
9anxiety disorder30.1HTR2A, DRD2
10pathological gambling30.0DRD4, DRD3, DRD2
11personality disorder30.0DRD4, DRD3, DRD2
12substance abuse30.0DRD4, DRD3, DRD2
13alcohol dependence30.0HTR2A, DRD4, DRD2
14psychotic disorder29.9NOTCH4, DRD2, DRD3, DRD4, HTR2A, DTNBP1
15blindness10.8
16bipolar i disorder10.4
17schizophreniform disorder10.4
18dementia10.2
19hepatitis10.2
20multiple sclerosis10.2
21endogenous depression10.1DISC1
22oppositional defiant disorder10.1DRD4
23schizotypal personality disorder10.1
24hepatitis b10.1
25cerebritis10.1
26acute porphyria10.1
27basal cell carcinoma10.1
28myocarditis10.1
29myopathy10.1
30neutropenia10.1
31porphyria10.1
32thrombocytopenia10.1
33hyperprolinemia10.1
34tardive dyskinesia10.1
35hypoxia10.1
36memory impairment10.1
37leukopenia10.1
38argyria10.1
39early-onset schizophrenia10.1
40neuroleptic malignant syndrome10.1DRD2
41seasonal affective disorder10.0DRD4, HTR2A
42opiate dependence10.0DRD2, DRD3
43drug dependence10.0DRD3, DRD2
44autistic disorder10.0DRD4, DISC1
45antisocial personality disorder10.0DRD2, HTR2A
46drug addiction10.0DRD2, DRD3
47alcohol abuse10.0DRD2, DRD3
48delusional disorder10.0DRD4, DRD2
49panic disorder10.0HTR2A, DRD4
50movement disease10.0DRD3, DRD2

Graphical network of the top 20 diseases related to Schizoaffective Disorder:



Diseases related to schizoaffective disorder

Symptoms for Schizoaffective Disorder

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47OMIM
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Clinical features from OMIM:

181500

Drugs & Therapeutics for Schizoaffective Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Schizoaffective Disorder

Search NIH Clinical Center for Schizoaffective Disorder

Genetic Tests for Schizoaffective Disorder

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Anatomical Context for Schizoaffective Disorder

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33MalaCards
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MalaCards organs/tissues related to Schizoaffective Disorder:

33
Testes, Cortex, Prefrontal cortex

Animal Models for Schizoaffective Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Schizoaffective Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.1PRODH, DISC1, DRD4, DRD3, DRD2, NOTCH4
2MP:00053866.3DRD2, PRL, PRODH, DISC1, DTNBP1, HTR2A
3MP:00053766.3PRL, PRODH, DISC1, DTNBP1, DRD4, DRD3

Publications for Schizoaffective Disorder

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Sources:
52PubMed
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Articles related to Schizoaffective Disorder:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Schizoaffective Disorder in the DSM-5. (23707642)
2013
2
Relationship between the clinical global impression of severity for schizoaffective disorder scale and established mood scales for mania and depression. (23517884)
2013
3
Effort Testing in Schizophrenia and Schizoaffective Disorder: Validity Indicator Profile and Test of Memory Malingering Performance Characteristics. (24002172)
2013
4
Differences between first episode schizophrenia and schizoaffective disorder. (23528796)
2013
5
Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia. (23672587)
2013
6
Regarding "A Risperidone-induced Prolactinoma Resolved When A Woman with Schizoaffective Disorder Switched to Ziprasidone: A Case Report". (23556137)
2013
7
HFE mutations and transferrin C1/C2 polymorphism among Croatian patients with schizophrenia and schizoaffective disorder. (21643746)
2012
8
Cognitive-behavioral therapy for obsessive-compulsive disorder as a comorbidity with schizophrenia or schizoaffective disorder. (22123432)
2012
9
Rabbit syndrome following discontinuation of paliperidone in a patient with schizoaffective disorder. (22926613)
2012
10
Oral paliperidone: a review of its use in the management of schizoaffective disorder. (21649452)
2011
11
Switching from quetiapine to ziprasidone: a sixteen-week, open-label, multicenter study evaluating the effectiveness and safety of ziprasidone in outpatient subjects with schizophrenia or schizoaffective disorder. (21430488)
2011
12
Case report on the management of depression in schizoaffective disorder, bipolar type focusing on lithium levels and measurement-based care. (22134460)
2011
13
Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls. (21106252)
2011
14
Weak association of the platelet-derived growth factor beta (PDGFB) and PDGF receptor beta (PDGFRB) genes with schizophrenia and schizoaffective disorder. (20950212)
2011
15
Understanding schizoaffective disorder: from psychobiology to psychosocial functioning. (21190647)
2010
16
Treatment of schizoaffective disorder - a challenge for evidence-based psychiatry. (19570108)
2010
17
Determinants of work outcome in neuroleptic-resistant schizophrenia and schizoaffective disorder: cognitive impairment and clozapine treatment. (20452677)
2010
18
Remission in schizophrenia: one-year Italian prospective study of risperidone long-acting injectable (RLAI) in patients with schizophrenia or schizoaffective disorder. (19790173)
2009
19
Effects of a 10-week weight control program on obese patients with schizophrenia or schizoaffective disorder: a 12-month follow up. (19067997)
2009
20
Combination therapy or monotherapy for the depressed type of schizoaffective disorder. (19557104)
2009
21
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
22
A cross-sectional evaluation of adiponectin plasma levels in patients with schizophrenia and schizoaffective disorder. (18930377)
2008
23
Is schizoaffective disorder a distinct categorical diagnosis? A critical review of the literature. (19337453)
2008
24
Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder. (18928413)
2008
25
Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar type. (18344743)
2008
26
Quetiapine in the successful combination treatment of an assaultive patient with treatment-resistant schizoaffective disorder. (17517541)
2007
27
An observational study of the effectiveness and safety of intramuscular olanzapine in the treatment of acute agitation in patients with bipolar mania or schizophrenia/schizoaffective disorder. (17708578)
2007
28
A comparison of basic and social cognition between schizophrenia and schizoaffective disorder. (17258431)
2007
29
The impact of insight on functioning in patients with schizophrenia or schizoaffective disorder receiving risperidone long-acting injectable. (18091190)
2007
30
Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder. (16875781)
2006
31
Treatment with rosuvastatin for severe dyslipidemia in patients with schizophrenia and schizoaffective disorder. (17194266)
2006
32
Cognitive discernible factors between schizophrenia and schizoaffective disorder. (16125294)
2005
33
Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder. (16115690)
2005
34
Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study. (16061761)
2005
35
Aripiprazole is effective against the symptoms of schizophrenia and schizoaffective disorder. (14769657)
2004
36
Combination of "atypical" antipsychotic medication in the management of treatment-resistant schizophrenia and schizoaffective disorder. (14687862)
2004
37
Clinical experience with aripiprazole treatment in ten elderly patients with schizophrenia or schizoaffective disorder: retrospective case studies. (15520608)
2004
38
Acceptability and disintegration rates of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorder. (15560318)
2004
39
Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. (12716249)
2003
40
Clozapine: in prevention of suicide in patients with schizophrenia or schizoaffective disorder. (12665398)
2003
41
Risperidone reduced the risk of relapse in outpatient schizophrenia and schizoaffective disorder. (12180444)
2002
42
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
43
Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. (10653215)
2000
44
Schizophrenia and schizoaffective disorder treated with high doses of olanzapine. (10350037)
1999
45
The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. (10067950)
1999
46
Use of the CAGE questionnaire in older adults with schizophrenia or schizoaffective disorder. (10438700)
1999
47
Olanzapine-induced psychotic mania in bipolar schizoaffective disorder. (10497709)
1999
48
Change in plasma prolactin and clinical response to haloperidol in schizophrenia and schizoaffective disorder. (9829650)
1998
49
Wernicke-Korsakoff amnestic syndrome secondary to malnutrition in a patient with schizoaffective disorder. (9845417)
1998
50
Treatment of negative symptoms in schizophrenia and schizoaffective disorder by selegiline augmentation of antipsychotic medication. A pilot study examining the role of dopamine. (8627275)
1996

Variations for Schizoaffective Disorder

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Expression for genes affiliated with Schizoaffective Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schizoaffective Disorder

Search GEO for disease gene expression data for Schizoaffective Disorder.

Pathways for genes affiliated with Schizoaffective Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 51PharmGKB, 30KEGG
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Pathways related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PRL, NRG3
2
Show member pathways
9.7NRG3, PRL
39.0DRD4, DRD2
48.9DRD3, DRD4, HTR2A
5
Show member pathways
8.6DRD2, DRD3, DRD4
6
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
8.6DRD2, DRD3, DRD4
78.6DRD4, DRD3, DRD2
8
Show member pathways
8.1DRD2, DRD3, DRD4, HTR2A
9
Show member pathways
8.1HTR2A, DRD4, DRD3, DRD2
10
Show member pathways
7.6PRL, HTR2A, DRD4, DRD3, DRD2
11
Show member pathways
7.0PRL, HTR2A, DRD4, DRD3, DRD2, NRG3

Compounds for genes affiliated with Schizoaffective Disorder

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 24HMDB, 61Tocris Bioscience
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Compounds related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1(+)-sulpiride298.9DRD2, DRD3, DRD4
2(-)-sulpiride298.9DRD2, DRD3, DRD4
3eticlopride45 299.9DRD4, DRD2, DRD3
4sch 23390458.9DRD4, DRD3, DRD2
5flupenthixol45 51 1110.9PRL, DRD2, HTR2A
6piribedil29 459.8DRD3, DRD4, DRD2
7benzamide3 459.8DRD4, DRD3, DRD2
8melperone458.8DRD2, DRD4, HTR2A
9buspirone45 29 1110.8HTR2A, PRL, DRD2
10rotigotine29 45 1110.8DRD2, DRD3, DRD4
11loxapine29 45 1110.8HTR2A, DRD2, DRD4
12paroxetine45 51 29 1111.7PRL, HTR2A, DRD4, DRD3
13amoxapine29 45 1110.7DRD2, PRL, HTR2A
14amisulpride45 29 1110.7DRD3, PRL, HTR2A, DRD2
15trimipramine45 51 1110.7DRD2, HTR2A, PRL
16pimozide29 45 51 1111.6DRD3, DRD2, PRL, HTR2A
17nemonapride45 51 2910.6DRD4, PRL, DRD3, DRD2
18sulpiride45 29 1110.5DRD3, PRL, DRD4, DRD2
19(+)-butaclamol45 299.5HTR2A, DRD2, DRD4, DRD3
20raclopride45 299.5DRD3, DRD4, DRD2, HTR2A
21roxindole29 459.5HTR2A, DRD4, DRD3, DRD2
22spiperone45 299.5DRD2, DRD3, DRD4, HTR2A
23piperazine45 119.5HTR2A, DRD4, DRD2, DRD3
24ropinirole45 119.4DRD2, HTR2A, DRD4, DRD3
25quinpirole45 299.4DRD4, DRD2, HTR2A, DRD3
26fluphenazine29 45 51 1111.4PRL, HTR2A, DRD4, DRD2
27asenapine29 119.4DRD2, DRD3, DRD4, HTR2A
28ritanserin45 299.4PRL, HTR2A, DRD2
29methamphetamine45 51 1110.4DRD2, DTNBP1, DRD4, DRD3
30iloperidone51 45 29 1111.2DRD2, DRD3, HTR2A, DRD4, NRG3
31remoxipride45 119.1HTR2A, DRD2, DRD3, DRD4, PRL
32terguride45 299.1DRD4, DRD2, DRD3, HTR2A, PRL
33lisuride45 29 1110.1DRD4, DRD2, DRD3, HTR2A, PRL
34pergolide45 29 1110.1DRD2, DRD3, DRD4, HTR2A, PRL
35paliperidone45 119.1PRL, DRD2, DRD3, DRD4, HTR2A
36pramipexole45 29 51 1111.1PRL, DRD3, DRD4, DRD2, HTR2A
37cabergoline45 29 1110.1DRD3, DRD4, DRD2, PRL, HTR2A
38aripiprazole29 45 51 24 1112.1PRL, DRD4, HTR2A, DRD3, DRD2
39levodopa45 119.1DRD4, DRD2, PRL, DRD3
40ziprasidone29 51 45 1111.1PRL, HTR2A, DRD4, DRD3, DRD2
41apomorphine29 45 1110.1PRL, DRD4, DRD3, DRD2, HTR2A
42quetiapine45 51 29 24 1112.1DRD2, DRD3, DRD4, HTR2A, PRL
43bromocriptine45 29 1110.0DRD4, PRL, DRD3, DRD2, HTR2A
44chlorpromazine29 45 51 1111.0DRD3, DRD2, PRL, HTR2A, DRD4
45risperidone45 51 29 61 24 1113.0DRD2, PRL, HTR2A, DRD4, DRD3
46olanzapine45 51 29 24 1112.0DRD4, DRD3, HTR2A, DRD2, PRL
47norepinephrine45 24 119.6DRD2, HTR2A, DRD4, PRL, DRD3
48clozapine45 29 51 1110.6DRD3, DRD4, DRD2, HTR2A, DTNBP1, PRL
49haloperidol45 51 29 3 1111.5DRD2, DRD3, DRD4, HTR2A, DTNBP1, PRL
50dopamine45 29 24 1110.2DISC1, PRL, DTNBP1, DRD4, DRD3, DRD2

GO Terms for genes affiliated with Schizoaffective Disorder

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Sources:
16Gene Ontology
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Cellular components related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.2DRD2, DRD3
2synaptic vesicle membraneGO:0306728.8DRD2, DTNBP1
3postsynaptic densityGO:0140698.8DISC1, DTNBP1, DRD2
4dendritic spineGO:0431978.6DRD2, DRD4, DTNBP1
5axonGO:0304248.5DRD2, HTR2A, DTNBP1
6integral component of plasma membraneGO:0058877.5NOTCH4, HTR2A, DRD4, DRD3, DRD2, NRG3

Biological processes related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of multicellular organism growthGO:0400149.7DRD3, PRL
2positive regulation of neuroblast proliferationGO:0020529.6DISC1, DRD2
3regulation of locomotion involved in locomotory behaviorGO:0903259.6DRD2, DRD3
4negative regulation of dopamine receptor signaling pathwayGO:0601609.6DRD2, DRD3
5regulation of dopamine uptake involved in synaptic transmissionGO:0515849.6DRD3, DRD2
6regulation of cAMP metabolic processGO:0308149.6DRD3, DRD2
7G-protein coupled receptor internalizationGO:0020319.6DRD2, DRD3
8prepulse inhibitionGO:0601349.5DRD3, DRD2
9positive regulation of renal sodium excretionGO:0358159.5DRD2, DRD3
10response to morphineGO:0432789.5DRD3, DRD2
11response to cocaineGO:0422209.5DRD3, DRD2
12circadian regulation of gene expressionGO:0329229.5DRD3, DRD2
13negative regulation of synaptic transmission, glutamatergicGO:0519679.5DRD2, HTR2A
14negative regulation of protein kinase B signalingGO:0518989.4DRD2, DRD3
15social behaviorGO:0351769.4DRD3, DRD4
16regulation of dopamine secretionGO:0140599.4DTNBP1, HTR2A, DRD3
17temperature homeostasisGO:0016599.4DRD2, HTR2A
18negative regulation of blood pressureGO:0457769.4DRD3, DRD2
19positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.4DRD4, DRD2
20negative regulation of voltage-gated calcium channel activityGO:19013869.4DRD4, DRD2
21behavioral response to ethanolGO:0481499.4DRD2, DRD4
22protein localizationGO:0081049.4DRD2, DISC1
23positive regulation of cytokinesisGO:0324679.3DRD3, DRD2
24release of sequestered calcium ion into cytosolGO:0512099.3HTR2A, DRD2
25response to histamineGO:0347769.0DRD4, DRD3, DRD2
26adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.0DRD2, DRD3, DRD4
27dopamine metabolic processGO:0424179.0DRD2, DRD3, DRD4
28negative regulation of protein secretionGO:0507099.0DRD4, DRD3, DRD2
29synaptic transmission, dopaminergicGO:0019639.0DRD4, DRD3, DRD2
30arachidonic acid secretionGO:0504829.0DRD2, DRD3, DRD4
31negative regulation of adenylate cyclase activityGO:0071949.0DRD2, DRD3, DRD4
32response to amphetamineGO:0019759.0DRD4, DRD3, DRD2
33visual learningGO:0085428.9DRD2, DRD3
34response to drugGO:0424938.6HTR2A, DRD3, DRD2
35behavioral response to cocaineGO:0481488.5DRD2, DRD3, DRD4, HTR2A
36cellular calcium ion homeostasisGO:0068748.5HTR2A, DRD4, DRD3, DRD2

Molecular functions related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154598.7DRD2, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015918.7DRD2, DRD3, DRD4
3dopamine bindingGO:0352408.5DRD4, DRD3, DRD2
4drug bindingGO:0081448.1DRD2, DRD3, DRD4, HTR2A
5protein bindingGO:0055157.0DISC1, DTNBP1, DRD4, DRD3, DRD2, NOTCH4

Products for genes affiliated with Schizoaffective Disorder

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  • Antibodies
  • Proteins
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Sources for Schizoaffective Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet