MCID: SCH012
MIFTS: 57

Schizoaffective Disorder malady

Neuronal diseases category

Summaries for Schizoaffective Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.

MalaCards: Schizoaffective Disorder is related to schizophrenia and bipolar disorder. An important gene associated with Schizoaffective Disorder is DISC1 (disrupted in schizophrenia 1), and among its related pathways are GPCRs, Other and Dopamine receptors. The compounds pergolide and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include testes, cortex and prefrontal cortex, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:63 Schizoaffective disorder (abbreviated as SZA or SAD) is a mental disorder characterized by disordered... more...

Description from OMIM:46 181500

Aliases & Classifications for Schizoaffective Disorder

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

schizoaffective disorder 8 46 10 44 60


External Ids:

Disease Ontology8 DOID:5418
ICD9CM27 295.7
MeSH34 D011618
ICD1025 F25, F25.9

Related Diseases for Schizoaffective Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Schizoaffective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9COMT, DRD3, HTR2A, DISC1
2bipolar disorder31.3BDNF, SLC6A4
3psychotic disorder30.9COMT, DTNBP1, BDNF, HTR2A, DRD2, DRD3
4mood disorder30.8HTR2A, BDNF, COMT, DISC1, NOS1, DRD2
5bipolar i disorder30.7DTNBP1
6personality disorder30.7DRD4, DRD2, DRD3, SLC6A4
7obsessive-compulsive disorder30.6COMT, BDNF, HTR2A, DRD2, DRD3, DRD4
8obesity30.6COMT, HTR2A, NOS1, DRD4, DRD2
9anxiety disorder30.4BDNF, SLC6A4, CYP2D6, COMT, DRD2, HTR2A
10dementia30.2COMT, BDNF, HTR2A, CYP2D6, NOS1
11multiple sclerosis30.2COMT, BDNF, DRD2, CYP2D6
12hepatitis30.2CYP2D6, COMT
13substance abuse30.0SLC6A4, DRD3, DRD4, DRD2
14alcohol dependence30.0SLC6A4, DRD4, DRD2, HTR2A
15cocaine dependence30.0SLC6A4, DRD3, DRD2
16pathological gambling30.0DRD2, DRD3, DRD4
17delusional disorder30.0DRD2, DRD4
18eating disorder30.0HTR2A, COMT, BDNF, SLC6A4
19parkinson's disease30.0COMT, DRD3, BDNF, DRD2, CYP2D6, CYP2D7P1
20schizophreniform disorder10.4
21sexual disorder10.4
22major depressive disorder10.2
23prolactinoma10.2
24adjustment disorder10.2
25wernicke-korsakoff syndrome10.0
26hepatitis c10.0
27lewy body dementia10.0
28cerebritis10.0
29dependent personality disorder10.0
30schizotypal personality disorder10.0
31hepatitis b10.0
32acute porphyria10.0
33amnestic disorder10.0
34basal cell carcinoma10.0
35dissociative disorder10.0
36impulse control disorder10.0
37myocarditis10.0
38myopathy10.0
39neutropenia10.0
40porphyria10.0
41thrombocytopenia10.0
42withdrawal disorder10.0
43restless legs syndrome10.0DRD2
44heroin dependence10.0DRD2, DRD4
45panic disorder10.0COMT, HTR2A, DRD4, SLC6A4
46borderline personality disorder10.0SLC6A4
47chronic fatigue syndrome10.0SLC6A4
48fibromyalgia10.0SLC6A4, COMT, HTR2A
49antisocial personality disorder10.0DRD2, HTR2A, SLC6A4
50nicotine dependence10.0DRD4, DRD2, SLC6A4

Graphical network of the top 20 diseases related to Schizoaffective Disorder:



Diseases related to schizoaffective disorder

Clinical Features for Schizoaffective Disorder

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

181500

Drugs & Therapeutics for Schizoaffective Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Schizoaffective Disorder

Drug clinical trials:

Search ClinicalTrials for Schizoaffective Disorder

Search NIH Clinical Center for Schizoaffective Disorder

Search CenterWatch for Schizoaffective Disorder

Genetic Tests for Schizoaffective Disorder

About this section

Anatomical Context for Schizoaffective Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Schizoaffective Disorder:

32
Testes, Cortex, Prefrontal cortex

Animal Models for Schizoaffective Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Schizoaffective Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.4DTNBP1, BDNF, DRD2, DRD3, DRD4, DISC1
2MP:000538610.3NOS1, COMT, DTNBP1, BDNF, HTR2A, DRD2
3MP:000363110.1DRD4, DRD3, DRD2, BDNF, COMT, DISC1

Publications for Schizoaffective Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Schizoaffective Disorder:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Effort Testing in Schizophrenia and Schizoaffective Disorder: Validity Indicator Profile and Test of Memory Malingering Performance Characteristics. (24002172)
2013
2
Differences between first episode schizophrenia and schizoaffective disorder. (23528796)
2013
3
Anxiety disorder comorbidity in bipolar disorder, schizophrenia and schizoaffective disorder. (22906962)
2013
4
Anhedonia of patients with schizophrenia and schizoaffective disorder is attributed to personality-related factors rather than to state-dependent clinical symptoms. (23518785)
2013
5
Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder. (23846733)
2013
6
Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. (23938173)
2013
7
Valproate-induced hyperammonemic encephalopathy followed by benzodiazepine withdrawal in a patient with schizoaffective disorder: a differential diagnosis. (24026753)
2013
8
Treatment and outcomes of an Australian cohort of outpatients with bipolar I or schizoaffective disorder over twenty-four months: implications for clinical practice. (23244301)
2012
9
Delayed response to repetitive transcranial magnetic stimulation treatment for intractable auditory hallucinations in schizoaffective disorder. (22563574)
2012
10
Ten-year quality of life outcomes among patients with schizophrenia and schizoaffective disorder II. Predictive value of psychosocial factors. (21964946)
2012
11
Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. (21784156)
2011
12
Impact of olanzapine or risperidone treatment on insulin sensitivity in schizophrenia or schizoaffective disorder. (21435142)
2011
13
Treatment adherence in schizophrenia and schizoaffective disorder. (21527119)
2011
14
Impact of traumatic and violent victimization experiences in individuals with schizophrenia and schizoaffective disorder. (20921860)
2010
15
Predictive value of early changes in triglycerides and weight for longer-term changes in metabolic measures during olanzapine, ziprasidone or aripiprazole treatment for schizophrenia and schizoaffective disorder post hoc analyses of 3 randomized, controlled clinical trials. (21105275)
2010
16
Aripiprazole for patients with schizophrenia and schizoaffective disorder: an open-label, randomized, study versus haloperidol. (19238124)
2009
17
Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease. (19300384)
2009
18
Changes in metabolic syndrome parameters in patients with schizoaffective disorder who participated in a randomized, placebo-controlled trial of topiramate. (23051050)
2009
19
Consciously-perceived generalized epileptiform discharges in a man with schizoaffective disorder. (19751791)
2009
20
Prevalence of metabolic syndrome among patients with schizophrenia or schizoaffective disorder in Taiwan. (19426161)
2009
21
The diagnoses of schizophrenia, schizoaffective disorder, bipolar disorder and unipolar depression: interrater reliability and congruence between DSM-IV and ICD-10. (19609099)
2009
22
A cross-sectional study of problem and pathological gambling in patients with schizophrenia/schizoaffective disorder. (19538900)
2009
23
Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior response. (19497244)
2009
24
Aripiprazole: dose-response relationship in schizophrenia and schizoaffective disorder. (19689167)
2009
25
Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder. (18928413)
2008
26
Mortality in schizophrenia and schizoaffective disorder: an Olmsted County, Minnesota cohort: 1950-2005. (18031996)
2008
27
Are schizophrenia and schizoaffective disorder neuropsychologically distinguishable? (18031992)
2008
28
Quetiapine in the successful combination treatment of an assaultive patient with treatment-resistant schizoaffective disorder. (17517541)
2007
29
A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort. (18052560)
2007
30
A 24-month prospective outcome study of first-episode schizophrenia and schizoaffective disorder within an early psychosis intervention program. (17915975)
2007
31
fMRI study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk. (17719745)
2007
32
Maintenance therapy with once-monthly administration of long-acting injectable risperidone in patients with schizophrenia or schizoaffective disorder: a pilot study of an extended dosing interval. (17261186)
2007
33
microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. (17326821)
2007
34
Open-label steady-state pharmacokinetic drug interaction study on co-administered quetiapine fumarate and divalproex sodium in patients with schizophrenia, schizoaffective disorder, or bipolar disorder. (17729385)
2007
35
Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder. (16875781)
2006
36
An autoimmune or an inflammatory process in patients with schizophrenia, schizoaffective disorder, and in their biological relatives. (16530388)
2006
37
Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder. (16202177)
2006
38
Dose-dependent rapid-onset akathisia with aripiprazole in patients with schizoaffective disorder. (19412470)
2006
39
Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12-week randomized controlled clinical trial. (16669719)
2006
40
Lack of impact of race on the efficacy and safety of long-acting risperidone versus placebo in patients with schizophrenia or schizoaffective disorder. (15933481)
2005
41
Aripiprazole and depression in schizoaffective disorder. (15741489)
2005
42
The profiling of ego defenses in clinical material to assess recovery from schizoaffective disorder. (14965856)
2004
43
Efficacy and safety of long-acting risperidone in elderly patients with schizophrenia and schizoaffective disorder. (15352149)
2004
44
Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. (12363115)
2002
45
Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder. (12223252)
2002
46
CSF thyrotropin-releasing hormone concentrations differ in patients with schizoaffective disorder from patients with schizophrenia or mood disorders. (11591431)
2001
47
The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. (10067950)
1999
48
Intergenerational CAG repeat expansion at ERDA1 in a family with childhood-onset depression, schizoaffective disorder, and recurrent major depression. (10050972)
1999
49
Schizoaffective disorder : consistency of diagnosis. (21430806)
1999
50
An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder. (9690695)
1998

Genetic Variations for Schizoaffective Disorder

About this section

Expression for genes affiliated with Schizoaffective Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Schizoaffective Disorder

Search GEO for disease gene expression data for Schizoaffective Disorder.

Pathways for genes affiliated with Schizoaffective Disorder

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Schizoaffective Disorder

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1pergolide28 44 1112.9CYP2D6, COMT, HTR2A, DRD2, DRD3, DRD4
2remoxipride44 1111.9DRD4, PRL, CYP2D6, DRD3, DRD2, HTR2A
3olanzapine49 44 28 11 2414.9COMT, BDNF, HTR2A, DRD2, DRD3, DRD4
4pramipexole44 49 28 1113.9COMT, HTR2A, DRD2, BDNF, DRD3, DRD4
5ropinirole44 1111.8DRD3, COMT, HTR2A, DRD2, DRD4, CYP2D6
6haloperidol44 28 2 49 1114.8CYP2D6, PRL, DRD4, DRD3, DRD2, HTR2A
7lisuride28 44 1112.8DRD4, DRD3, DRD2, PRL, CYP2D6, HTR2A
8paroxetine44 49 28 1113.8COMT, BDNF, SLC6A4, CYP2D6, PRL, DRD4
9quetiapine44 49 28 11 2414.8BDNF, PRL, HTR2A, DRD2, DRD3, DRD4
10maoa4410.8DRD4, SLC6A4, COMT, DRD2, BDNF, HTR2A
11iloperidone49 44 28 1113.8NRG3, DRD4, HTR2A, DRD2, DRD3, CYP2D6
12paliperidone44 1111.8DRD2, HTR2A, CYP2D6, DRD4, PRL, DRD3
13methamphetamine44 49 1112.8NOS1, SLC6A4, CYP2D6, DRD4, DRD3, DRD2
14chlorpromazine44 28 49 1113.8BDNF, CYP2D6, PRL, DRD3, DRD2, DRD4
15risperidone28 44 49 59 11 2415.8CYP2D6, DRD3, DRD2, HTR2A, BDNF, COMT
16cabergoline28 44 1112.8DRD3, PRL, DRD4, COMT, DRD2, HTR2A
17aripiprazole28 49 44 11 2414.8DRD4, HTR2A, DRD2, DRD3, PRL, CYP2D6
18clozapine44 28 49 1113.8DRD2, DRD3, DTNBP1, BDNF, HTR2A, DRD4
19fluoxetine49 44 28 1113.8BDNF, DRD2, PRL, CYP2D6, NOS1, SLC6A4
20ziprasidone49 28 44 1113.8CYP2D6, PRL, DRD4, DRD3, HTR2A, DRD2
21cocaine44 1111.8BDNF, COMT, DRD3, DRD4, PRL, CYP2D6
22apomorphine44 28 1112.8DRD4, DRD3, DRD2, HTR2A, PRL, COMT
23dopamine44 28 11 2413.8NOS1, SLC6A4, CYP2D6, PRL, DISC1, DRD4
24terguride28 4411.8DRD4, HTR2A, DRD3, DRD2, PRL
25fluphenazine28 44 1112.8CYP2D6, PRL, DRD2, HTR2A, DRD4
26amoxapine44 28 1112.8CYP2D6, HTR2A, DRD2, PRL, SLC6A4
27piperazine44 1111.8DRD2, DRD4, DRD3, HTR2A, CYP2D6
28levodopa44 1111.8CYP2D6, PRL, DRD2, DRD4, DRD3, BDNF
29norepinephrine44 11 2412.8BDNF, HTR2A, NOS1, DRD2, DRD3, DRD4
30bromocriptine28 44 1112.8HTR2A, DRD2, COMT, DRD4, DRD3, PRL
31mhpg4410.8DRD4, PRL, COMT, SLC6A4, BDNF
32pimozide28 49 44 1113.8HTR2A, PRL, DRD2, CYP2D6, DRD3
33trimipramine49 44 1112.8PRL, SLC6A4, HTR2A, DRD2, CYP2D6
34methylphenidate44 49 1112.8DRD2, CYP2D6, SLC6A4, COMT, DRD4
35amisulpride44 28 1112.7PRL, HTR2A, DRD2, DRD3
36Methotrimeprazine1110.7HTR2A, DRD2, DRD3, CYP2D6, DRD4
37mptp4410.7DRD3, DRD2, COMT, NOS1, BDNF, SLC6A4
385-hydroxytryptamine4410.7HTR2A, PRL, DRD4, DRD2, COMT, NOS1
39imipramine44 49 28 11 2414.7SLC6A4, NOS1, DRD3, HTR2A, BDNF, CYP2D6
40asenapine28 1111.7HTR2A, DRD2, DRD3, DRD4, CYP2D6
41nemonapride49 44 2812.7DRD3, DRD4, PRL, DRD2
42heroin44 49 1112.6COMT, DRD2, DRD3, DRD4, SLC6A4
43(+)-butaclamol28 4411.6DRD2, DRD4, DRD3, HTR2A
44nicotine44 49 28 1113.6DRD3, CYP2D6, NOS1, SLC6A4, DRD4, DRD2
45bupropion44 49 11 2413.5COMT, DRD3, CYP2D6, SLC6A4, DRD2
46mcpp4410.5SLC6A4, CYP2D6, PRL, HTR2A
47flupenthixol44 49 1112.4PRL, HTR2A, DRD2, CYP2D6
48rotigotine44 28 1112.4CYP2D6, DRD4, DRD2, DRD3
49minaprine44 1111.3SLC6A4, CYP2D6, DRD2, HTR2A
50duloxetine44 49 28 1113.1HTR2A, SLC6A4, CYP2D6, DRD3

GO Terms for genes affiliated with Schizoaffective Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic densityGO:01406910.5DISC1, DRD2, DTNBP1
2dendritic spineGO:04319710.3DTNBP1, DRD2, DRD4, NOS1
3integral to plasma membraneGO:00588710.1HTR2A, DRD2, DRD3, DRD4, NRG3, PCDH11X

Biological processes related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.8DRD3, DTNBP1, DRD2, HTR2A
2response to histamineGO:03477610.8DRD3, DRD4, DRD2
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD4, DRD2, DRD3
4dopamine metabolic processGO:04241710.8DRD4, DRD3, DRD2
5synaptic transmission, dopaminergicGO:00196310.8DRD3, DRD4, DRD2
6negative regulation of protein secretionGO:05070910.8DRD4, DRD3, DRD2
7behavioral response to cocaineGO:04814810.8DRD4, DRD2, DRD3
8arachidonic acid secretionGO:05048210.8DRD2, DRD3, DRD4
9response to drugGO:04249310.8COMT, DRD3, HTR2A, DRD2, PRL, SLC6A4
10cellular calcium ion homeostasisGO:00687410.8DRD2, DRD3, HTR2A, DRD4
11negative regulation of adenylate cyclase activityGO:00719410.8DRD4, DRD3, DRD2
12negative regulation of blood pressureGO:04577610.8NOS1, DRD2, DRD3
13response to amphetamineGO:00197510.8DRD2, DRD3, DRD4
14positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.8DRD2, DRD4
15social behaviorGO:03517610.8SLC6A4, DRD4, DRD3
16negative regulation of dopamine receptor signaling pathwayGO:06016010.8DRD3, DRD2
17negative regulation of voltage-gated calcium channel activityGO:190138610.8DRD4, DRD2
18regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD2, DRD3
19response to hypoxiaGO:00166610.7DRD2, SLC6A4, NOS1, BDNF
20regulation of cAMP metabolic processGO:03081410.7DRD3, DRD2
21circadian rhythmGO:00762310.7EGR3, PRL, SLC6A4
22multicellular organismal response to stressGO:03355510.7NOS1, PRL
23behavioral response to ethanolGO:04814910.7DRD2, DRD4
24negative regulation of synaptic transmission, glutamatergicGO:05196710.6DRD2, HTR2A
25negative regulation of potassium ion transportGO:04326710.6NOS1, HTR2A
26G-protein coupled receptor internalizationGO:00203110.6DRD3, DRD2
27prepulse inhibitionGO:06013410.5DRD3, DRD2
28temperature homeostasisGO:00165910.5HTR2A, DRD2
29positive regulation of renal sodium excretionGO:03581510.5DRD3, DRD2
30circadian regulation of gene expressionGO:03292210.4DRD2, DRD3
31neurotransmitter biosynthetic processGO:04213610.2COMT, NOS1

Molecular functions related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5DRD4, DRD3, DRD2
2drug bindingGO:00814410.3DRD3, HTR2A, DRD2, CYP2D6, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.2DRD4, DRD2, DRD3

Products for genes affiliated with Schizoaffective Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Schizoaffective Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet