MCID: SCH012
MIFTS: 57

Schizoaffective Disorder malady

Neuronal diseases category

Summaries for Schizoaffective Disorder

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.

MalaCards: Schizoaffective Disorder is related to schizophrenia and bipolar disorder. An important gene associated with Schizoaffective Disorder is DISC1 (disrupted in schizophrenia 1), and among its related pathways are GPCRs, Other and Dopamine receptors. The compounds pergolide and remoxipride have been mentioned in the context of this disorder. Affiliated tissues include testes, cortex and prefrontal cortex, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:63 Schizoaffective disorder (abbreviated as SZA or SAD) is a mental disorder characterized by disordered... more...

Description from OMIM:46 181500

Aliases & Classifications for Schizoaffective Disorder

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

schizoaffective disorder 8 46 10 44 60


External Ids:

Disease Ontology8 DOID:5418
ICD9CM27 295.7
MeSH34 D011618
ICD1025 F25, F25.9

Related Diseases for Schizoaffective Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Schizoaffective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.9COMT, DRD3, HTR2A, DISC1
2bipolar disorder31.3BDNF, SLC6A4
3psychotic disorder30.9COMT, DTNBP1, BDNF, HTR2A, DRD2, DRD3
4mood disorder30.8HTR2A, BDNF, COMT, DISC1, NOS1, DRD2
5bipolar i disorder30.7DTNBP1
6personality disorder30.7DRD4, DRD2, DRD3, SLC6A4
7obsessive-compulsive disorder30.6COMT, BDNF, HTR2A, DRD2, DRD3, DRD4
8obesity30.6COMT, HTR2A, NOS1, DRD4, DRD2
9anxiety disorder30.4BDNF, SLC6A4, CYP2D6, COMT, DRD2, HTR2A
10dementia30.2COMT, BDNF, HTR2A, CYP2D6, NOS1
11multiple sclerosis30.2COMT, BDNF, DRD2, CYP2D6
12hepatitis30.2CYP2D6, COMT
13substance abuse30.0SLC6A4, DRD3, DRD4, DRD2
14alcohol dependence30.0SLC6A4, DRD4, DRD2, HTR2A
15cocaine dependence30.0SLC6A4, DRD3, DRD2
16pathological gambling30.0DRD2, DRD3, DRD4
17delusional disorder30.0DRD2, DRD4
18eating disorder30.0HTR2A, COMT, BDNF, SLC6A4
19parkinson's disease30.0COMT, DRD3, BDNF, DRD2, CYP2D6, CYP2D7P1
20schizophreniform disorder10.4
21sexual disorder10.4
22major depressive disorder10.2
23prolactinoma10.2
24adjustment disorder10.2
25wernicke-korsakoff syndrome10.0
26hepatitis c10.0
27lewy body dementia10.0
28cerebritis10.0
29dependent personality disorder10.0
30schizotypal personality disorder10.0
31hepatitis b10.0
32acute porphyria10.0
33amnestic disorder10.0
34basal cell carcinoma10.0
35dissociative disorder10.0
36impulse control disorder10.0
37myocarditis10.0
38myopathy10.0
39neutropenia10.0
40porphyria10.0
41thrombocytopenia10.0
42withdrawal disorder10.0
43restless legs syndrome10.0DRD2
44heroin dependence10.0DRD2, DRD4
45panic disorder10.0COMT, HTR2A, DRD4, SLC6A4
46borderline personality disorder10.0SLC6A4
47chronic fatigue syndrome10.0SLC6A4
48fibromyalgia10.0SLC6A4, COMT, HTR2A
49antisocial personality disorder10.0DRD2, HTR2A, SLC6A4
50nicotine dependence10.0DRD4, DRD2, SLC6A4

Graphical network of the top 20 diseases related to Schizoaffective Disorder:



Diseases related to schizoaffective disorder

Clinical Features for Schizoaffective Disorder

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46OMIM
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Clinical features from OMIM:

181500

Drugs & Therapeutics for Schizoaffective Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Schizoaffective Disorder

Drug clinical trials:

Search ClinicalTrials for Schizoaffective Disorder

Search NIH Clinical Center for Schizoaffective Disorder

Search CenterWatch for Schizoaffective Disorder

Genetic Tests for Schizoaffective Disorder

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Anatomical Context for Schizoaffective Disorder

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32MalaCards
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MalaCards organs/tissues related to Schizoaffective Disorder:

32
Testes, Cortex, Prefrontal cortex

Animal Models for Schizoaffective Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Schizoaffective Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.4DTNBP1, BDNF, DRD2, DRD3, DRD4, DISC1
2MP:000538610.3NOS1, COMT, DTNBP1, BDNF, HTR2A, DRD2
3MP:000363110.1DRD4, DRD3, DRD2, BDNF, COMT, DISC1

Publications for Schizoaffective Disorder

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Sources:
50PubMed
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Articles related to Schizoaffective Disorder:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Predicting 10-year quality-of-life outcomes of patients with schizophrenia and schizoaffective disorders. (24405469)
2014
2
Relationship between the clinical global impression of severity for schizoaffective disorder scale and established mood scales for mania and depression. (23517884)
2013
3
Regarding "A Risperidone-induced Prolactinoma Resolved When A Woman with Schizoaffective Disorder Switched to Ziprasidone: A Case Report". (23556137)
2013
4
Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family. (23341099)
2013
5
Long-term remission in schizophrenia and schizoaffective disorder: results from the risperidone long-acting injectable versus quetiapine relapse prevention trial (ConstaTRE). (24167692)
2013
6
Identification of clinically meaningful relationships among cognition, functionality, and symptoms in subjects with schizophrenia or schizoaffective disorder. (23276482)
2013
7
Cognitive impairments in schizophrenia and schizoaffective disorder: relationship with clinical characteristics. (22456585)
2012
8
Long-term efficacy and safety of asenapine or olanzapine in patients with schizophrenia or schizoaffective disorder: an extension study. (22454251)
2012
9
The use of electroconvulsive therapy to treat schizoaffective disorder in a patient with pacemaker: a case report. (22706421)
2012
10
Executive dysfunction and memory impairment in schizoaffective disorder: a comparison with bipolar disorder, schizophrenia and healthy controls. (22357405)
2012
11
A randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of varenicline for smoking cessation in patients with schizophrenia or schizoaffective disorder. (22697191)
2012
12
Oral paliperidone: a review of its use in the management of schizoaffective disorder. (21649452)
2011
13
Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls. (21106252)
2011
14
White matter integrity and lack of insight in schizophrenia and schizoaffective disorder. (21429714)
2011
15
Determinants of work outcome in neuroleptic-resistant schizophrenia and schizoaffective disorder: cognitive impairment and clozapine treatment. (20452677)
2010
16
Efficacy of high-dose aripiprazole for treatment-resistant schizoaffective disorder: a case report. (21240152)
2010
17
Paliperidone extended-release in schizoaffective disorder: a randomized, controlled study comparing a flexible dose with placebo in patients treated with and without antidepressants and/or mood stabilizers. (20814330)
2010
18
Cognitive effects of antipsychotic dosage and polypharmacy: a study with the BACS in patients with schizophrenia and schizoaffective disorder. (19164494)
2010
19
Aripiprazole in schizophrenia and schizoaffective disorder: A review. (20152550)
2010
20
Association of Per3 gene with bipolar disorder: comment on "Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia". (21176035)
2010
21
Valproic acid-induced myopathy in a patient with schizoaffective disorder. (19593189)
2009
22
Effectiveness and tolerability of oral ziprasidone in psychiatric inpatients with an acute exacerbation of schizophrenia or schizoaffective disorder: a multicenter, prospective, and naturalistic study. (19358789)
2009
23
Clinical and pharmacoeconomic evaluation of switch to olanzapine in veterans with schizophrenia or schizoaffective disorder. (18362873)
2008
24
Rapidly disintegrating risperidone in subjects with schizophrenia or schizoaffective disorder: a summary of ten phase I clinical trials assessing taste, tablet disintegration time, bioequivalence, and tolerability. (17472821)
2007
25
Cardiovascular disease and metabolic risk factors in male patients with schizophrenia, schizoaffective disorder, and bipolar disorder. (17878500)
2007
26
Long-term safety and tolerability of long-acting injectable risperidone in patients with schizophrenia or schizoaffective disorder. (17049818)
2007
27
A 10-year retrospective study of inpatient adolescents with schizophrenia/schizoaffective disorder and substance use. (17145274)
2007
28
Predictors of risk for relapse in patients with schizophrenia or schizoaffective disorder during olanzapine drug therapy. (17010994)
2007
29
Insight and its relationship to clinical outcomes in patients with schizophrenia or schizoaffective disorder receiving long-acting risperidone. (16687995)
2006
30
Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol. (16953381)
2006
31
Electronically monitored adherence in outpatients with schizophrenia or schizoaffective disorder: a comparison of first- vs. second-generation antipsychotics. (16376522)
2006
32
Bipolar and depressive types of schizoaffective disorder in old age. (16582048)
2006
33
White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. (15741480)
2005
34
Effects of behavioral therapy on weight loss in overweight and obese patients with schizophrenia or schizoaffective disorder. (15705006)
2005
35
Effects of switching from olanzapine to risperidone on the prevalence of the metabolic syndrome in overweight or obese patients with schizophrenia or schizoaffective disorder: analysis of a multicenter, rater-blinded, open-label study. (16507379)
2005
36
Long-acting risperidone in stable patients with schizoaffective disorder. (16144783)
2005
37
Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (16043131)
2005
38
Treatment of hepatitis B and C co-infection in schizoaffective disorder. (16170206)
2005
39
Long-term maintenance therapy with quetiapine versus haloperidol decanoate in patients with schizophrenia or schizoaffective disorder. (15889952)
2005
40
Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidol. (14744169)
2004
41
Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. (12614996)
2003
42
Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. (12860772)
2003
43
Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. (12202271)
2002
44
Maintenance electroconvulsive therapy in affective and schizoaffective disorder. (11150895)
2001
45
Treatment of schizoaffective disorder with divalproex sodium. (11099889)
2000
46
Use of the CAGE questionnaire in older adults with schizophrenia or schizoaffective disorder. (10438700)
1999
47
Treatment of schizoaffective disorder and schizophrenia with mood symptoms. (10450252)
1999
48
Wernicke-Korsakoff amnestic syndrome secondary to malnutrition in a patient with schizoaffective disorder. (9845417)
1998
49
Suicide prevention effects associated with clozapine therapy in schizophrenia and schizoaffective disorder. (9712207)
1998
50
Lamotrigine in the treatment of schizoaffective disorder. (9778612)
1998

Genetic Variations for Schizoaffective Disorder

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Expression for genes affiliated with Schizoaffective Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schizoaffective Disorder

Search GEO for disease gene expression data for Schizoaffective Disorder.

Pathways for genes affiliated with Schizoaffective Disorder

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 51QIAGEN, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Schizoaffective Disorder

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1pergolide28 44 1112.9CYP2D6, COMT, HTR2A, DRD2, DRD3, DRD4
2remoxipride44 1111.9DRD4, PRL, CYP2D6, DRD3, DRD2, HTR2A
3olanzapine49 44 28 11 2414.9COMT, BDNF, HTR2A, DRD2, DRD3, DRD4
4pramipexole44 49 28 1113.9COMT, HTR2A, DRD2, BDNF, DRD3, DRD4
5ropinirole44 1111.8DRD3, COMT, HTR2A, DRD2, DRD4, CYP2D6
6haloperidol44 28 2 49 1114.8CYP2D6, PRL, DRD4, DRD3, DRD2, HTR2A
7lisuride28 44 1112.8DRD4, DRD3, DRD2, PRL, CYP2D6, HTR2A
8paroxetine44 49 28 1113.8COMT, BDNF, SLC6A4, CYP2D6, PRL, DRD4
9quetiapine44 49 28 11 2414.8BDNF, PRL, HTR2A, DRD2, DRD3, DRD4
10maoa4410.8DRD4, SLC6A4, COMT, DRD2, BDNF, HTR2A
11iloperidone49 44 28 1113.8NRG3, DRD4, HTR2A, DRD2, DRD3, CYP2D6
12paliperidone44 1111.8DRD2, HTR2A, CYP2D6, DRD4, PRL, DRD3
13methamphetamine44 49 1112.8NOS1, SLC6A4, CYP2D6, DRD4, DRD3, DRD2
14chlorpromazine44 28 49 1113.8BDNF, CYP2D6, PRL, DRD3, DRD2, DRD4
15risperidone28 44 49 59 11 2415.8CYP2D6, DRD3, DRD2, HTR2A, BDNF, COMT
16cabergoline28 44 1112.8DRD3, PRL, DRD4, COMT, DRD2, HTR2A
17aripiprazole28 49 44 11 2414.8DRD4, HTR2A, DRD2, DRD3, PRL, CYP2D6
18clozapine44 28 49 1113.8DRD2, DRD3, DTNBP1, BDNF, HTR2A, DRD4
19fluoxetine49 44 28 1113.8BDNF, DRD2, PRL, CYP2D6, NOS1, SLC6A4
20ziprasidone49 28 44 1113.8CYP2D6, PRL, DRD4, DRD3, HTR2A, DRD2
21cocaine44 1111.8BDNF, COMT, DRD3, DRD4, PRL, CYP2D6
22apomorphine44 28 1112.8DRD4, DRD3, DRD2, HTR2A, PRL, COMT
23dopamine44 28 11 2413.8NOS1, SLC6A4, CYP2D6, PRL, DISC1, DRD4
24terguride28 4411.8DRD4, HTR2A, DRD3, DRD2, PRL
25fluphenazine28 44 1112.8CYP2D6, PRL, DRD2, HTR2A, DRD4
26amoxapine44 28 1112.8CYP2D6, HTR2A, DRD2, PRL, SLC6A4
27piperazine44 1111.8DRD2, DRD4, DRD3, HTR2A, CYP2D6
28levodopa44 1111.8CYP2D6, PRL, DRD2, DRD4, DRD3, BDNF
29norepinephrine44 11 2412.8BDNF, HTR2A, NOS1, DRD2, DRD3, DRD4
30bromocriptine28 44 1112.8HTR2A, DRD2, COMT, DRD4, DRD3, PRL
31mhpg4410.8DRD4, PRL, COMT, SLC6A4, BDNF
32pimozide28 49 44 1113.8HTR2A, PRL, DRD2, CYP2D6, DRD3
33trimipramine49 44 1112.8PRL, SLC6A4, HTR2A, DRD2, CYP2D6
34methylphenidate44 49 1112.8DRD2, CYP2D6, SLC6A4, COMT, DRD4
35amisulpride44 28 1112.7PRL, HTR2A, DRD2, DRD3
36Methotrimeprazine1110.7HTR2A, DRD2, DRD3, CYP2D6, DRD4
37mptp4410.7DRD3, DRD2, COMT, NOS1, BDNF, SLC6A4
385-hydroxytryptamine4410.7HTR2A, PRL, DRD4, DRD2, COMT, NOS1
39imipramine44 49 28 11 2414.7SLC6A4, NOS1, DRD3, HTR2A, BDNF, CYP2D6
40asenapine28 1111.7HTR2A, DRD2, DRD3, DRD4, CYP2D6
41nemonapride49 44 2812.7DRD3, DRD4, PRL, DRD2
42heroin44 49 1112.6COMT, DRD2, DRD3, DRD4, SLC6A4
43(+)-butaclamol28 4411.6DRD2, DRD4, DRD3, HTR2A
44nicotine44 49 28 1113.6DRD3, CYP2D6, NOS1, SLC6A4, DRD4, DRD2
45bupropion44 49 11 2413.5COMT, DRD3, CYP2D6, SLC6A4, DRD2
46mcpp4410.5SLC6A4, CYP2D6, PRL, HTR2A
47flupenthixol44 49 1112.4PRL, HTR2A, DRD2, CYP2D6
48rotigotine44 28 1112.4CYP2D6, DRD4, DRD2, DRD3
49minaprine44 1111.3SLC6A4, CYP2D6, DRD2, HTR2A
50duloxetine44 49 28 1113.1HTR2A, SLC6A4, CYP2D6, DRD3

GO Terms for genes affiliated with Schizoaffective Disorder

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16Gene Ontology
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Cellular components related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic densityGO:01406910.5DISC1, DRD2, DTNBP1
2dendritic spineGO:04319710.3NOS1, DRD4, DRD2, DTNBP1
3integral to plasma membraneGO:00588710.1HTR2A, DRD2, DRD3, DRD4, NRG3, PCDH11X

Biological processes related to Schizoaffective Disorder according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.8DRD3, DRD2, HTR2A, DTNBP1
2response to histamineGO:03477610.8DRD2, DRD3, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD4, DRD3, DRD2
4dopamine metabolic processGO:04241710.8DRD2, DRD3, DRD4
5negative regulation of protein secretionGO:05070910.8DRD2, DRD3, DRD4
6behavioral response to cocaineGO:04814810.8DRD2, DRD3, DRD4
7synaptic transmission, dopaminergicGO:00196310.8DRD2, DRD3, DRD4
8arachidonic acid secretionGO:05048210.8DRD4, DRD3, DRD2
9response to drugGO:04249310.8COMT, HTR2A, DRD2, DRD3, PRL, SLC6A4
10cellular calcium ion homeostasisGO:00687410.8HTR2A, DRD2, DRD3, DRD4
11negative regulation of adenylate cyclase activityGO:00719410.8DRD4, DRD3, DRD2
12negative regulation of blood pressureGO:04577610.8NOS1, DRD3, DRD2
13response to amphetamineGO:00197510.8DRD2, DRD3, DRD4
14negative regulation of voltage-gated calcium channel activityGO:190138610.8DRD2, DRD4
15social behaviorGO:03517610.8SLC6A4, DRD4, DRD3
16negative regulation of dopamine receptor signaling pathwayGO:06016010.8DRD2, DRD3
17positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.8DRD2, DRD4
18regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
19response to hypoxiaGO:00166610.7BDNF, DRD2, SLC6A4, NOS1
20regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
21circadian rhythmGO:00762310.7SLC6A4, PRL, EGR3
22multicellular organismal response to stressGO:03355510.7NOS1, PRL
23behavioral response to ethanolGO:04814910.7DRD4, DRD2
24negative regulation of synaptic transmission, glutamatergicGO:05196710.6DRD2, HTR2A
25negative regulation of potassium ion transportGO:04326710.6HTR2A, NOS1
26G-protein coupled receptor internalizationGO:00203110.6DRD2, DRD3
27prepulse inhibitionGO:06013410.5DRD3, DRD2
28temperature homeostasisGO:00165910.5DRD2, HTR2A
29positive regulation of renal sodium excretionGO:03581510.5DRD2, DRD3
30circadian regulation of gene expressionGO:03292210.4DRD2, DRD3
31neurotransmitter biosynthetic processGO:04213610.2NOS1, COMT

Molecular functions related to Schizoaffective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5DRD4, DRD3, DRD2
2drug bindingGO:00814410.3CYP2D6, DRD4, DRD3, DRD2, HTR2A
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.2DRD2, DRD3, DRD4

Products for genes affiliated with Schizoaffective Disorder

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  • Antibodies
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Sources for Schizoaffective Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet