Schizoaffective Disorder malady

Disease Ontology: A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.⁶

MalaCards: Schizoaffective Disorder, also known as schizoaffective disease, is related to schizophrenia and bipolar disorder. An important gene associated with Schizoaffective Disorder is DISC1 (disrupted in schizophrenia 1), and among its related pathways are BMAL1:CLOCK/NPAS2 Activates Circadian Expression and RORA Activates Circadian Expression. The compounds pergolide and haloperidol have been mentioned in the context of this disorder. Affiliated tissues include cortex and prefrontal cortex, and related mouse phenotypes are taste/olfaction and reproductive system.

Wikipedia: Schizoaffective disorder is a psychiatric diagnosis that describes a mental disorder characterized by...⁴⁴ more...

OMIM: 181500

Aliases & Descriptions:

schizoaffective disorder 6 33 32 43 schizoaffective disease 8

Diseases related to schizoaffective disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 218)

id	Related Disease	Score	Top Affiliating Genes
1	schizophrenia	36.6	HTR2A, DRD3, DISC1, COMT
2	bipolar disorder	31.4	CLOCK, HTR1A, SLC6A4
3	bipolar i disorder	27.0	CNR1, VTRNA3-1P, CLOCK, BHLHE41, BDNF, ARNTL
4	blindness	25.8	CNR1, INS, MAOA, HTR1A, HTR2A, HLA-B
5	tic disorder	13.8	HTR2A, DRD2, DRD4
6	opiate dependence	13.8	DRD2, DRD3, COMT
7	major affective disorder	13.8	HTR2A, DRD2, NOS1, SLC6A4
8	anxiety-related personality traits	13.8	BDNF, COMT, SLC6A4
9	myoclonus-dystonia	13.8	DRD2, DRD3, DRD4
10	childhood-onset schizophrenia	13.7	TPH1, NOS1, PRL, PRODH
11	cocaine abuse	13.7	BDNF, DRD2, PRL, SLC6A4
12	drug addiction	13.7	BDNF, DRD2, DRD3, NTS
13	enuresis	13.7	HTR2A, DRD4, NOS1
14	anorexia nervosa	13.7	BDNF, HTR2A
15	asperger syndrome	13.7	DISC1, SHANK3, SLC6A4
16	gilles de la tourette syndrome	13.6	DRD2, DRD4, COMT, ADRA1A
17	novelty seeking personality	13.6	MAOA, DRD2, DRD4, COMT
18	tetrahydrobiopterin deficiency	13.6	TPH1, NOS1, PRL
19	melancholia	13.6	MAOA, PRL, SLC6A4
20	pathological gambling	13.5	MAOA, DRD2, DRD3, DRD4, SLC6A4
21	delayed sleep phase syndrome	13.5	CLOCK, PER2, PER3
22	sepiapterin reductase deficiency	13.5	TPH1, DRD2, NOS1
23	neuroleptic malignant syndrome	13.5	HTR1A, HTR2A, DRD2, CYP2D6
24	antisocial personality disorder	13.5	MAOA, HTR2A, DRD2, COMT, PRL, SLC6A4
25	rett syndrome	13.4	BDNF, TPH1, DRD2, NTS, PRL
26	cannabis dependence	13.4	CNR1, COMT, GABRA2
27	attention deficit hyperactivity disorder	13.4	BDNF, MAOA, HTR2A, DRD2, DRD3, DRD4
28	premature ejaculation	13.4	HTR1A, PRL, SLC6A4
29	borderline personality disorder	13.4	MAOA, TPH1, COMT, PRL, SLC6A4
30	dyskinesia of esophagus	13.4	HTR1A, HTR2A, DRD2, DRD3, CYP2D6, COMT
31	personality disorder	13.4	MAOA, TPH1, DRD2, DRD3, DRD4, SLC6A4
32	migraine without aura	13.4	HTR1A, DRD2, DRD3, DRD4, COMT, PRL
33	manic-depressive illness	13.4	MAOA, TPH1, DRD2, DRD3, DRD4, SLC6A4
34	post-traumatic stress disorder	13.4	CNR1, BDNF, MAOA, DRD2
35	central nervous system disease	13.4	CNR1, BDNF, CHRNA7, HTR2A, CYP2D6, SLC6A4
36	essential tremor	13.3	TPH1, DRD3, CYP2D6, COMT, GABRA1, GABRR1
37	insomnia	13.3	CLOCK, HTR1A, HTR2A, SLC6A4, AANAT
38	huntington's disease	13.3	CNR1, BDNF, DRD2, NTS, NOS1
39	cognitive disease	13.3	BDNF, CHRNA7, HTR1A, DRD3, COMT
40	memory impairment	13.3	CNR1, BDNF, HTR1A, HTR2A
41	corpus callosum	13.3	PCDH11X, PCDH11Y, BDNF, NRG3, COMT
42	restless legs syndrome	13.2	MAOA, DRD2, DRD3, DRD4, NTS, NOS1
43	advanced sleep phase syndrome	13.2	CLOCK, CSNK1D, CSNK1E, PER1, PER2, PER3
44	social phobia	13.2	MAOA, HTR1A, DRD2, PRL, SLC6A4
45	postpartum depression	13.2	BDNF, MAOA, HTR1A, COMT, PRL, SLC6A4
46	phobia	13.2	MAOA, HTR1A, DRD2, COMT, PRL, SLC6A4
47	alcohol abuse	13.2	HTR2A, DRD2, DRD3, DISC1, COMT, PRL
48	toxic encephalopathy	13.2	BDNF, MAOA, TPH1, NOS1, SLC6A4
49	cluster headache	13.1	CLOCK, INS, NOS1, PRL
50	multiple system atrophy	13.1	BDNF, TPH1, DRD2, CYP2D6, SST, SLC6A4

Clinical features from OMIM: 181500

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to schizoaffective disorder:

²²

MGI Mouse Phenotypes related to schizoaffective disorder:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.8	CNR1, BDNF, DRD2, SHANK3, GABRR1
2	reproductive system phenotype	MP:0005389	7.9	RORB, PER1, PER2, RGS4, ADIPOQ, GABRG2
3	skeleton phenotype	MP:0005390	7.7	GABRB2, PER2, NOS1, PLA2G6, CRY2, PPARG
4	vision/eye phenotype	MP:0005391	7.5	NOS1, EGR3, CSNK2A1, RORB, PER3, GABRR1
5	adipose tissue phenotype	MP:0005375	7.4	PPARG, CRY2, NOS1, RGS4, ADIPOQ, NTS
6	renal/urinary system phenotype	MP:0005367	7.2	ADIPOQ, ADRA1A, PER2, PER1, COMT, NOS1
7	no phenotypic analysis	MP:0003012	7.0	TIMELESS, DBP, CSNK1D, CSNK1E, PER2, RGS4
8	muscle phenotype	MP:0005369	6.7	PLA2G4A, PLA2G6, NOS1, EGR3, CSNK2A1, SLC6A4
9	integument phenotype	MP:0010771	6.4	CRY2, SHANK3, PRL, SLC6A4, PER2, RGS4
10	nervous system phenotype	MP:0003631	6.3	DRD2, GABRB2, GABRG2, RGS4, SLC6A4, DRD3
11	cardiovascular system phenotype	MP:0005385	5.8	PLA2G4A, NOS1, NOTCH4, COMT, CSNK2A1, NPAS2
12	growth/size phenotype	MP:0005378	4.4	CSNK1D, PRODH, SHANK3, NFIL3, NOTCH4, NOS1
13	mortality/aging	MP:0010768	4.1	SLC6A4, CSNK2A1, CSNK1D, DBP, TIMELESS, EGR3
14	homeostasis/metabolism phenotype	MP:0005376	3.6	CNR1, CLOCK, BDNF, CHRNA7, ARNTL, INS
15	behavior/neurological phenotype	MP:0005386	2.3	RELN, DRD3, DRD4, DISC1, SST, NTS

Articles related to schizoaffective disorder:

(show all 36)

id	Title	Authors	Year	Affiliating Genes
1	Gender differences in the effects of peroxisome proli ferator-activated receptor I^2 gene polymorphisms on metabolic adversity in pati ents with schizophrenia or schizoaffective disorder. (21095215)	Chen C.H.... Huang M.C.	2011	PPARG
2	Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. (20583128)	Green E.K.... Craddock N.	2010	GABRA2, GABRB2, GABRG2
3	Novel mutations in the calreticulin gene core promote r and coding sequence in schizoaffective disorder. (19760677)	Nabi M.O.... Ohadi M.	2010	CALR
4	Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (19839995)	Mansour H.A.... Nimgaonkar V.L.	2009	CSNK1D, CSNK2A1, CNR1
5	Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. (19336781)	Lencz T.... Malhotra A.K.	2009	BDNF
6	A variant in the reelin gene increases the risk of sc hizophrenia and schizoaffective disorder but not bipolar disorder. (19436241)	PisantAc A.... Darvasi A.	2009	RELN
7	The efficacy, safety, and tolerability of aripiprazol e for the treatment of schizoaffective disorder: results from a pooled analysis of a sub-population of subjects from two randomized, double-blind, placebo-con trolled, pivotal trials. (19230981)	Glick I.D.... AssunAsALo-Talbott S.	2009	PRL
8	A cross-sectional evaluation of adiponectin plasma levels in patients with schizophrenia and schizoaffective disorder. (18930377)	Hanssens L.... De Hert M.	2008	ADIPOQ
9	Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. (18823757)	Meltzer H.Y.... Jayathilake K.	2008	SULT4A1
10	BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder. (18562188)	Nadalin S.... Buretic-Tomljanovic A.	2008	PLA2G6, PLA2G4A
11	Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder. (18320559)	Adams D.H.... Houston J.P.	2008	DRD3
12	A mutation in the calreticulin gene promoter in a fam ily case of schizoaffective disorder leads to its aberrant transcriptional acti vation. (18801343)	Nunes A.... Soriano S.	2008	CALR
13	Alterations in somatostatin mRNA expression in the do rsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder. (18203698)	MORRIS H.M.... Lewis D.A.	2008	SST
14	Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. (17192894)	Martin L.F.... Olincy A.	2007	CHRNA7, CHRFAM7A
15	Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. (16507006)	Mansour H.A.... Nimgaonkar V.L.	2006	ARNTL, TIMELESS
16	A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. (15940305)	Sachs N.A.... Margolis R.L.	2005	DISC1
17	Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (16043131)	Clark D.A.... Kerwin R.W.	2005	ADRA1A
18	Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. (16203953)	Hamshere M.L.... Craddock N.	2005	DISC1
19	The association of the HLA in patients with schizophrenia, schizoaffective disorder, and in their biological relatives. (15949652)	Nunes S.O.... Itano E.N.	2005	HLA-B
20	Hyperprolinemia is a risk factor for schizoaffective disorder. (15494707)	Jacquet H.... Campion D.	2005	PRODH
21	Effect of therapy with atypical antipsychotic drugs on prolactin concentration in patients with schizophrenia and schizoaffective disorders. (16848233)	Gorobets L.N.	2005	PRL
22	ProtocadherinX/Y, a candidate gene-pair for schizophrenia and schizoaffective disorder: a DHPLC investigation of genomic sequence. (15274028)	Giouzeli M.... Crow T.J.	2004	PCDH11X, PCDH11Y
23	Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. (15386212)	Hodgkinson C.A.... Malhotra A.K.	2004	DISC1
24	Efficacy and tolerability of ziprasidone versus risperidone in patients with acute exacerbation of schizophrenia or schizoaffective disorder: an 8-week, double-blind, multicenter trial. (15641867)	Addington D.E.... Romano S.J.	2004	PRL
25	Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. (15257633)	Swainston Harrison T.... Perry C.M.	2004	DRD2, HTR1A, HTR2A
26	Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidol. (14744169)	Volavka J.... Lieberman J.A.	2004	PRL
27	Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. (15169685)	Meltzer H.Y.... Rein W.	2004	NTS
28	Randomized, controlled, double-blind multicenter comp arison of the efficacy and tolerability of ziprasidone and olanzapine in acutel y ill inpatients with schizophrenia or schizoaffective disorder. (15465981)	Simpson G.M.... Siu C.O.	2004	INS
29	Efficacy and safety of aripiprazole and haloperidol v ersus placebo in patients with schizophrenia and schizoaffective disorder. (12363115)	Kane J.M.... Ali M.W.	2002	PRL
30	Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. (12140115)	Canuso C.M.... Green A.I.	2002	PRL
31	NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. (11239712)	Ujike H.... Kuroda S.	2001	NOTCH4
32	Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder. (11311923)	Ujike H.... Kuroda S.	2001	KCNN3
33	Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special? (11063791)	Meszaros K.... Aschauer H.N.	2000	DRD3
34	An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. (11204346)	Nolan K.A.... Saito T.	2000	MAOA, TPH1, SLC6A4
35	Change in plasma prolactin and clinical response to h aloperidol in schizophrenia and schizoaffective disorder. (9829650)	Chou J.C.... Cooper T.B.	1998	PRL
36	Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. (9619160)	Lachman H.M.... Volavka J.	1998	COMT

Genes related to schizoaffective disorder according to GeneCards:

(show top 50)    (show all 69)

id	Symbol	Description	Score	GeneCards Section Context
1	DISC1	disrupted in schizophrenia 1	11.0	Publications
2	NRG3	neuregulin 3	11.0	Summaries
3	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
4	NOS1	nitric oxide synthase 1 (neuronal)	11.0
5	PRODH	proline dehydrogenase (oxidase) 1	11.0	Publications
6	NOTCH4	notch 4	11.0	Publications
7	DRD3	dopamine receptor D3	11.0	Publications
8	DTNBP1	dystrobrevin binding protein 1	11.0
9	DRD4	dopamine receptor D4	11.0
10	COMT	catechol-O-methyltransferase	11.0	Publications
11	PCDH11X	protocadherin 11 X-linked	11.0	Publications
12	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0
13	DRD2	dopamine receptor D2	11.0	Publications
14	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
15	BDNF	brain-derived neurotrophic factor	11.0	Publications
16	PRL	prolactin	11.0	Publications
17	VTRNA3-1P	vault RNA 3-1, pseudogene	11.0	Publications
18	FXYD6	FXYD domain containing ion transport regulator 6	11.0
19	BHLHE41	basic helix-loop-helix family, member e41	11.0	Publications
20	EGR3	early growth response 3	11.0	Publications
21	NFIL3	nuclear factor, interleukin 3 regulated	11.0	Publications
22	GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	11.0	Publications
23	NR1D1	nuclear receptor subfamily 1, group D, member 1	11.0	Publications
24	DBP	D site of albumin promoter (albumin D-box) binding protein	11.0	Publications
25	CHRFAM7A	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion	11.0	Publications
26	SULT4A1	sulfotransferase family 4A, member 1	11.0	Publications
27	TIMELESS	timeless homolog (Drosophila)	11.0	Publications
28	AANAT	aralkylamine N-acetyltransferase	11.0	Publications
29	GABRP	gamma-aminobutyric acid (GABA) A receptor, pi	11.0	Publications
30	CRY2	cryptochrome 2 (photolyase-like)	11.0	Publications
31	PER1	period homolog 1 (Drosophila)	11.0	Publications
32	GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	11.0	Publications
33	GABRR2	gamma-aminobutyric acid (GABA) A receptor, rho 2	11.0	Publications
34	PER3	period homolog 3 (Drosophila)	11.0	Publications
35	SHANK3	SH3 and multiple ankyrin repeat domains 3	11.0
36	RGS4	regulator of G-protein signaling 4	11.0
37	GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	11.0	Publications
38	CSNK1E	casein kinase 1, epsilon	11.0	Publications
39	CSNK1D	casein kinase 1, delta	11.0	Publications
40	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	11.0	Publications
41	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	11.0	Publications
42	NTS	neurotensin	11.0	Publications
43	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
44	TPH1	tryptophan hydroxylase 1	11.0	Publications
45	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.0	Publications
46	PCDH11Y	protocadherin 11 Y-linked	11.0	Publications
47	CALR	calreticulin	11.0	Publications
48	PER2	period homolog 2 (Drosophila)	11.0	Publications
49	CLOCK	clock homolog (mouse)	11.0	Publications
50	ADRA1A	adrenoceptor alpha 1A	11.0	Publications

Pathways related to schizoaffective disorder according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	BMAL1:CLOCK/NPAS2 Activates Circadian Expression38	10.2	PER2, PER1, DBP, CRY2, BHLHE41
2	RORA Activates Circadian Expression38	10.2	NPAS2, NR1D1, ARNTL
3	Metabolic States and Circadian Oscillators36	10.0	ARNTL, CRY2, NPAS2, PER1, CLOCK
4	Amine ligand-binding receptors38	9.9	ADRA1A, DRD4, DRD3, DRD2, HTR2A, HTR1A
5	Benzodiazepine Pathway, Pharmacodynamics34	9.9	GABRA1, GABRG2, GABRB2
6	Circadian Clock in Mammals36	9.8	PER3, CLOCK, ARNTL, NR1D1, CRY2, CSNK1E
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.8	MAOA, HTR1A, HTR2A, TPH1, SLC6A4
8	Neuroscience3	9.7	RGS4, EGR3, NOTCH4, NOS1, DTNBP1, HTR1A
9	Translation _Regulation of EIF2 activity41	9.6	CSNK1E, CSNK1D, CSNK2A1
10	Translation Regulation activity of EIF210	9.4	CSNK2A1, CSNK1E, CSNK1D, INS
11	GABA signaling in brain10	9.3	GABRP, GABRG3, GABRA1, GABRG2, GABRG1, GABRB2
12	Circadian rhythm - mammal20	9.2	ARNTL, NR1D1, CRY2, CSNK1D, CSNK1E, NPAS2
13	Neuronal System38	9.1	GABRR2, GABRR1, GABRG3, GABRA1, GABRG2, GABRB2
14	Akt Signaling36	9.1	GABRG3, GABRA1, GABRG2, GABRG1, GABRB2, GABRA6
15	Sperm Motility36	8.5	GABRR2, GABRR1, GABRG3, GABRA1, GABRG2, GABRG1
16	Neuroactive ligand-receptor interaction20	7.8	GABRR2, PRL, DRD4, DRD3, DRD2, HTR2A

Compounds related to schizoaffective disorder according to GeneDecks:

(show top 50)    (show all 285)

id	Compound	Score	Top Affiliating Genes
1	pergolide32 9 9	12.0	HTR1A, HTR2A, DRD2, DRD3, DRD4, CYP2D6
2	haloperidol32 34 9 9	12.9	RGS4, SLC6A4, NTS, DRD4, DRD3, HTR2A
3	risperidone32 34 9 18 9	13.9	ADRA1A, SLC6A4, BDNF, HTR1A, HTR2A, DRD2
4	pramipexole32 9 9	11.8	PRL, COMT, DRD4, DRD3, DRD2, HTR2A
5	paliperidone32 9 9	11.8	PRL, DRD4, DRD3, DRD2, HTR2A, HTR1A
6	maoa32	9.7	HTR1A, HTR2A, MAOA, BDNF, SLC6A4, COMT
7	methamphetamine32 9 9	11.6	DRD2, DRD3, DRD4, TPH1, BDNF, MAOA
8	paroxetine32 34 9 9	12.6	MAOA, HTR1A, HTR2A, TPH1, DRD4, COMT
9	amoxapine32 9 9	11.6	ADRA1A, GABRA1, SLC6A4, CYP2D6, DRD2, PRL
10	apomorphine32 9 9	11.5	HTR2A, DRD2, DRD3, DRD4, NTS, PLA2G6
11	cabergoline32 9 9	11.5	DRD2, DRD4, PRL, COMT, SST, HTR1A
12	quetiapine32 9 18 9	12.5	DRD3, ADRA1A, PRL, CYP2D6, DRD4, DRD2
13	fluoxetine32 34 9 9	12.4	CNR1, BDNF, MAOA, HTR1A, HTR2A, TPH1
14	quazepam32 9 9	11.3	GABRR2, GABRR1, GABRP, GABRG3, GABRA1, GABRG2
15	Prazepam9 9	10.3	GABRG2, GABRA1, GABRG3, GABRP, GABRR1, GABRR2
16	Fludiazepam9 9	10.3	GABRA2, GABRB2, GABRG1, GABRG2, GABRA1, GABRG3
17	Halazepam9 9	10.3	GABRA2, GABRB2, GABRG1, GABRG2, GABRA1, GABRG3
18	Adinazolam9 9	10.3	GABRG3, GABRP, GABRR1, GABRR2, GABRA1, GABRG2
19	fluvoxamine32 34 9 9	12.3	BDNF, MAOA, HTR1A, CYP2D6, SLC6A4, CLOCK
20	Cinolazepam9 9	10.3	GABRA2, GABRB2, GABRG1, GABRG2, GABRA1, GABRG3
21	Clotiazepam9 9	10.3	GABRA2, GABRB2, GABRG1, GABRG2, GABRA1, GABRG3
22	estazolam32 9 9	11.3	GABRG2, GABRA1, GABRG3, GABRP, GABRR1, GABRR2
23	(+)-bicuculline42	9.3	GABRG3, GABRP, GABRA1, GABRG2, GABRG1, GABRB2
24	sr 95531 hydrobromide42	9.3	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
25	triazolam32 9 9	11.3	GABRG1, GABRG2, GABRA1, GABRG3, GABRP, GABRR1
26	clobazam34 32 9 9	12.3	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
27	Clorazepate9 9	10.3	GABRG3, GABRP, GABRR1, GABRR2, GABRA2, GABRA6
28	chlordiazepoxide32 9 9	11.2	GABRR2, CYP2D6, GABRA2, GABRA6, GABRB2, GABRG1
29	nitrazepam32 9 9	11.2	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
30	flurazepam32 9 9	11.2	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
31	Oxazepam9 9	10.2	GABRG1, GABRG2, GABRA1, GABRG3, GABRP, GABRR1
32	melatonin32 42 9 18 9	13.2	ARNTL, PER2, RGS4, AANAT, CALR, TPH1
33	Temazepam9 9	10.2	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
34	muscimol32 42	10.2	GABRA6, GABRB2, GABRG1, GABRG2, GABRA1, GABRG3
35	lorazepam32 34 9 9	12.2	GABRP, GABRR1, GABRR2, GABRG3, GABRA1, GABRG2
36	clonazepam32 9 9	11.1	MAOA, GABRA2, GABRB2, GABRG1, GABRG2, GABRA1
37	diazepam32 34 9 9	12.1	BDNF, GABRG3, GABRA1, GABRP, GABRG1, GABRB2
38	bromazepam32 9 9	11.0	GABRG2, GABRA1, GABRG3, GABRP, GABRR1, GABRR2
39	alprazolam32 9 9	11.0	MAOA, GABRA2, GABRA6, GABRB2, GABRG1, GABRG2
40	clozapine32 34 9 9	12.0	CHRNA7, HTR1A, HTR2A, DRD2, DRD3, DRD4
41	cocaine32 9 9	11.0	COMT, NOS1, PLA2G6, BDNF, CYP2D6, DRD4
42	levodopa32 9 9	10.9	DRD4, DRD3, CYP2D6, SST, NTS, PRL
43	olanzapine32 34 9 18 9	12.7	ADIPOQ, BDNF, INS, HTR1A, HTR2A, DRD2
44	5-hydroxytryptamine32	8.4	CNR1, CHRNA7, MAOA, HTR1A, HTR2A, TPH1
45	glutamate32	8.2	CNR1, CSNK2A1, PRODH, SHANK3, COMT, NOS1
46	midazolam32 9 9	10.0	GABRP, GABRR1, GABRR2, GABRG3, PPARG, GABRA2
47	gaba32 42	8.7	RELN, CNR1, BDNF, CHRNA7, GABRR2, GABRR1
48	nmda32 42	8.6	DRD2, DRD3, HTR1A, MAOA, CHRNA7, CNR1
49	dopamine32 9 18 9	10.4	CHRNA7, BDNF, CLOCK, MAOA, DRD4, DRD3
50	norepinephrine32 9 18 9	10.4	NOS1, COMT, PRL, SLC6A4, AANAT, ADRA1A

Cellular components related to schizoaffective disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chloride channel complex	GO:034707	8.9	GABRR2, GABRR1, GABRP, GABRG3, GABRA1, GABRG2
2	postsynaptic membrane	GO:045211	8.4	CHRFAM7A, GABRR2, GABRR1, GABRP, GABRG3, GABRA1
3	cell junction	GO:030054	8.4	GABRG2, GABRA1, GABRG3, GABRP, GABRR1, GABRR2
4	integral to plasma membrane	GO:005887	7.8	SLC6A4, ADRA1A, GABRA6, GABRB2, GABRG2, GABRA1
5	cytosol	GO:005829	7.0	COMT, CSNK1D, CSNK1E, CSNK2A1, NPAS2, SLC6A4
6	plasma membrane	GO:005886	5.6	GABRA6, GABRA2, ADRA1A, SLC6A4, CSNK2A1, CSNK1D

Biological processes related to schizoaffective disorder according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to histamine	GO:034776	10.6	DRD4, DRD3, DRD2
2	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.6	DRD2, DRD3, DRD4
3	behavioral response to cocaine	GO:048148	10.5	DRD4, DRD3, DRD2
4	regulation of dopamine secretion	GO:014059	10.4	HTR2A, DRD2, DRD3
5	dopamine metabolic process	GO:042417	10.4	DRD4, DRD3, DRD2
6	social behavior	GO:035176	10.4	SLC6A4, SHANK3, DRD4, DRD3
7	entrainment of circadian clock	GO:009649	10.3	CLOCK, ARNTL2, PER1
8	circadian regulation of gene expression	GO:032922	10.2	PER1, CSNK1D, DRD3, DRD2, BHLHE41, CLOCK
9	response to light stimulus	GO:009416	10.2	AANAT, PER1, DRD2
10	synaptic transmission, dopaminergic	GO:001963	10.2	DRD4, DRD3, DRD2
11	synaptic transmission, GABAergic	GO:051932	10.2	GABRA1, GABRG2, GABRB2
12	arachidonic acid secretion	GO:050482	10.2	DRD2, DRD3, DRD4, PLA2G4A
13	negative regulation of protein secretion	GO:050709	10.1	DRD4, DRD3, DRD2, INS
14	response to cocaine	GO:042220	10.1	CNR1, DRD2, DRD3
15	memory	GO:007613	10.0	SLC6A4, SHANK3, HTR2A, CHRNA7, CNR1
16	neurotransmitter biosynthetic process	GO:042136	9.8	MAOA, NOS1, COMT
17	negative regulation of blood pressure	GO:045776	9.7	ADIPOQ, DRD3, DRD2, CNR1
18	ion transmembrane transport	GO:034220	9.4	GABRR2, GABRR1, GABRG3, GABRA1, GABRG2, GABRB2
19	gamma-aminobutyric acid signaling pathway	GO:007214	9.3	GABRA2, GABRA6, GABRB2, GABRG1, GABRG2, GABRA1
20	circadian rhythm	GO:007623	9.2	CLOCK, AANAT, PER3, PER2, ARNTL, ARNTL2
21	response to drug	GO:042493	9.0	ADRA1A, SLC6A4, COMT, PPARG, SST, DRD3
22	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.0	PER3, PER2, PER1, TIMELESS, NFIL3, CRY2
23	synaptic transmission	GO:007268	8.2	GABRG1, GABRG2, GABRA1, GABRG3, GABRR1, GABRR2

Molecular functions related to schizoaffective disorder according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.5	DRD2, DRD3, DRD4
2	dopamine binding	GO:035240	10.3	DRD2, DRD3, DRD4
3	benzodiazepine receptor activity	GO:008503	10.2	GABRG2, GABRA6, GABRA2
4	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	GO:000982	10.1	CLOCK, ARNTL, ARNTL2
5	protein binding transcription factor activity	GO:000988	10.1	CRY2, PER1, PER2
6	serotonin binding	GO:051378	9.7	HTR2A, HTR1A, MAOA
7	Hsp90 protein binding	GO:051879	9.5	ARNTL, CSNK2A1, NPAS2
8	signal transducer activity	GO:004871	9.5	PER3, PER2, PER1, NPAS2, ARNTL2, ARNTL
9	extracellular ligand-gated ion channel activity	GO:005230	9.3	GABRA6, GABRG1, GABRG2, GABRA1, GABRG3, GABRP
10	GABA-A receptor activity	GO:004890	9.1	GABRA2, GABRR2, GABRA6, GABRB2, GABRG1, GABRG2
11	chloride channel activity	GO:005254	9.1	GABRR2, GABRR1, GABRP, GABRG3, GABRA1, GABRG2
12	drug binding	GO:008144	8.8	GABRA1, PPARG, CYP2D6, DRD4, DRD3, DRD2