MCID: SCH015
MIFTS: 79

Schizophrenia malady

Genetic diseases (common), Mental diseases categories

Aliases & Classifications for Schizophrenia

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Aliases & Descriptions for Schizophrenia:

Name: Schizophrenia 46 30 8 9 10 44 32 61
Schizoaffective Disorder 46 8 10 44 61
Schizophrenia, Susceptibility to 9 20 22
Schizophrenia 12 46 9 61
 
Schizophrenia 9 22
Schizophrenia-1 8
Schizophrenia 1 61


Classifications:



Summaries for Schizophrenia

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MedlinePlus:32 Schizophrenia is a serious brain illness. people who have it may hear voices that aren't there. they may think other people are trying to hurt them. sometimes they don't make sense when they talk. the disorder makes it hard for them to keep a job or take care of themselves. symptoms of schizophrenia usually start between ages 16 and 30. men often develop symptoms at a younger age than women. people usually do not get schizophrenia after age 45. there are three types of symptoms: psychotic symptoms distort a person's thinking. these include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements. "negative" symptoms make it difficult to show emotions and to function normally. a person may seem depressed and withdrawn. cognitive symptoms affect the thought process. these include trouble using information, making decisions, and paying attention. no one is sure what causes schizophrenia. your genes, environment, and brain chemistry may play a role. there is no cure. medicine can help control many of the symptoms. you may need to try different medicines to see which works best. you should stay on your medicine for as long as your doctor recommends. additional treatments can help you deal with your illness from day to day. these include therapy, family education, rehabilitation, and skills training. nih: national institute of mental health

MalaCards based summary: Schizophrenia, also known as schizoaffective disorder, is related to bipolar disorder and mood disorder, and has symptoms including eeg abnormality, autosomal dominant inheritance and hallucinations. An important gene associated with Schizophrenia is DISC1 (disrupted in schizophrenia 1), and among its related pathways is Monoamine GPCRs. The drugs carbamazepine and chlorpromazine and the compounds dopamine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.

OMIM:46 Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is... (181500) more...

Wikipedia:64 Schizophrenia (/?sk?ts??fr?ni?/ or /?sk?ts??fri?ni?/) is a mental disorder often characterized by... more...

Descriptions from OMIM:46 604906,603013

Related Diseases for Schizophrenia

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Diseases in the Schizophrenia family:

Schizophrenia 16 Schizophrenia 10
Schizophrenia 4 Schizophrenia 15
Schizophrenia 17

Diseases related to Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 344)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder32.8DRD3, NRG1, COMT, HTR2A, DISC1, DAO
2mood disorder32.2HTR2A, COMT, DRD3, DAOA, NRG1, DISC1
3psychotic disorder31.9DAOA, DISC1, HTR2A, COMT, DRD3, NRG1
4obsessive-compulsive disorder31.7DRD3, COMT, HTR2A
5antisocial personality disorder31.5HTR2A
6alcohol dependence31.5DRD3, HTR2A, COMT
7panic disorder31.3HTR2A, COMT
8attention deficit-hyperactivity disorder31.3COMT, HTR2A
9substance dependence31.2DRD3, COMT
10alcohol abuse31.2COMT, DRD3
11narcolepsy31.2COMT, HTR2A
12pathological gambling31.1DRD3
13anxiety disorder31.0COMT, HTR2A
14eating disorder30.8COMT, HTR2A
15alzheimer disease30.8COMT, DRD3, RTN4R, HTR2A, NRG1
16gilles de la tourette syndrome30.7COMT, HTR2A, DRD3
17generalized anxiety disorder30.6HTR2A
18paranoid schizophrenia11.0
19childhood-onset schizophrenia10.9
20tardive dyskinesia10.8
21neuronitis10.8
22blindness10.8
23migraine10.7MTHFR, COMT, HTR2A, DRD3
24personality disorder10.7
25nicotine dependence, protection against10.7MTHFR, HTR2A, COMT
26cerebritis10.6
27bulimia nervosa10.6HTR2A, COMT
28fibromyalgia10.6HTR2A, COMT
29bipolar i disorder10.6
30essential tremor10.6DRD3
31schizophreniform disorder10.6
32schizotypal personality disorder10.5
33parkinson disease, late-onset10.5COMT, DRD3, HTR2A
34stroke, ischemic10.5MTHFR, NRG1
35dementia10.5
36brain disease10.4
37hyperprolactinemia10.4
38delusional disorder10.4
39autism spectrum disorder10.4
40substance abuse10.4
41malignant glioma10.4CHI3L1, HTR2A, COMT, NRG1
42cannabis abuse10.4
43obesity10.4
44cerebral atrophy10.3
45borna disease10.3
46mutism10.3
47learning disability10.3
48mental retardation10.3
49schizophrenia 1710.3
50klinefelter's syndrome10.3

Graphical network of the top 20 diseases related to Schizophrenia:



Diseases related to schizophrenia

Symptoms for Schizophrenia

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Symptoms by clinical synopsis from OMIM:

181500

Clinical features from OMIM:

181500,604906,603013

HPO human phenotypes related to Schizophrenia:

(show all 16)
id Description Frequency HPO Source Accession
1 eeg abnormality 25% HP:0002353
2 autosomal dominant inheritance HP:0000006
3 hallucinations HP:0000738
4 delusions HP:0000746
5 heterogeneous HP:0001425
6 social and occupational deterioration HP:0007086
7 schizophrenia HP:0100753
8 ectopic kidney HP:0000086
9 renal agenesis HP:0000104
10 hypertelorism HP:0000316
11 protruding ear HP:0000411
12 frontal bossing HP:0002007
13 short stature HP:0004322
14 flat occiput HP:0005469
15 partially duplicated kidney HP:0008738
16 short proximal phalanx of the 4th toe HP:0100396

Genetic Tests for Schizophrenia

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Genetic tests related to Schizophrenia:

id Genetic test Affiliating Genes
1 Schizophrenia20 22 TAAR6
2 Schizophrenia 922

Anatomical Context for Schizophrenia

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MalaCards organs/tissues related to Schizophrenia:

31
Brain, Cortex, Prefrontal cortex, Testes, Eye, Temporal lobe, Cingulate cortex, Thalamus, Amygdala, Cerebellum, Kidney, Pituitary, Bone, Endothelial, Heart, Lung, Monocytes, T cells, Olfactory bulb, Caudate nucleus, Whole blood, Thyroid, Myeloid, Liver, Breast, Skin, Prostate, Nk cells, Hypothalamus, Fetal brain

Animal Models for Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Schizophrenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.1RTN4R, DISC1, MTHFR, SYN2, COMT, DRD3
2MP:000538610.8NRG1, DAO, RTN4R, DISC1, HTR2A, SYN2

Publications for Schizophrenia

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Articles related to Schizophrenia:

(show top 50)    (show all 6027)
idTitleAuthorsYear
1
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
2
Modeling Heterogeneous Patients with a Clinical Diagnosis of Schizophrenia with Induced Pluripotent Stem Cells. (24331955)
2013
3
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
4
Revisiting disrupted-in-schizophrenia 1 as a scaffold protein. (23832957)
2013
5
Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. (23301017)
2013
6
Paradoxical downregulation of HLA-A expression by IFNI^ associated with schizophrenia and noncoding genes. (23083632)
2013
7
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
8
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
9
Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia. (22094384)
2012
10
Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. (21850710)
2011
11
Association study of the frizzled 3 gene with Chinese Va schizophrenia. (22027177)
2011
12
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. (20603450)
2010
13
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
14
Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. (19892407)
2010
15
Schizophrenia, brain disease and meta-analyses: integrating the pieces and testing Fusar-Poli's hypothesis. (19651477)
2010
16
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. (19844207)
2010
17
Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. (18553389)
2009
18
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (18394866)
2008
19
Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. (17898419)
2008
20
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
21
Molecular mechanisms of schizophrenia. (17982252)
2007
22
Association analysis of AKT1 and schizophrenia in a UK case control sample. (17383860)
2007
23
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
24
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
25
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). (16828464)
2006
26
Associations between serum brain-derived neurotrophic factor levels and clinical phenotypes in schizophrenia patients. (16386272)
2006
27
Interpreting the association between cannabis use and increased risk for schizophrenia. (16060598)
2005
28
Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. (16086287)
2005
29
Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. (15647480)
2005
30
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
31
Family-based association study of synapsin II and schizophrenia. (15449241)
2004
32
Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia. (15081577)
2004
33
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (12815740)
2003
34
Association of the hSERT and SLC6A4 polymorphic markers of the serotonin transporter gene with schizophrenia in different ethnic groups]. (12942632)
2003
35
Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. (12746393)
2003
36
Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. (11920853)
2002
37
Quetiapine-induced improvement of tardive dyskinesia in three patients with schizophrenia. (12177588)
2002
38
Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry. (11793166)
2002
39
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
40
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
41
Schizophrenia and schizoaffective disorder treated with high doses of olanzapine. (10350037)
1999
42
The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. (10067950)
1999
43
Change in plasma prolactin and clinical response to haloperidol in schizophrenia and schizoaffective disorder. (9829650)
1998
44
Initial 'schizophrenia-like' psychosis in Pick's disease: case study with neuroimaging and neuropathology, and implications for frontotemporal dysfunction in schizophrenia. (8929764)
1995
45
Sydenham's chorea and schizophrenia: a case report. (7547648)
1995
46
Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. (8094629)
1993
47
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
48
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
49
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Schizophrenia

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Clinvar genetic disease variations for Schizophrenia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DISC1DISC1, HAPLOTYPE, HEP3undetermined variantPathogenic

Expression for genes affiliated with Schizophrenia

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Search GEO for disease gene expression data for Schizophrenia.

Pathways for genes affiliated with Schizophrenia

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Pathways related to Schizophrenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7TAAR6, DRD3, HTR2A

Compounds for genes affiliated with Schizophrenia

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Compounds related to Schizophrenia according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 24 1114.5DRD3, DAOA, DAO, DISC1, MTHFR, HTR2A
2glutamate4411.3NRG1, COMT, DAO, DAOA, DRD3, MTHFR
3nmda44 2812.3COMT, NRG1, DRD3, DAOA, DAO
4antipsychotics5011.1COMT, MTHFR, HTR2A
5ropinirole44 1112.1HTR2A, DRD3, COMT
6pergolide44 28 1113.1DRD3, COMT, HTR2A
7pramipexole44 28 50 1114.1COMT, DRD3, HTR2A
8cabergoline44 28 1113.1COMT, HTR2A, DRD3
9paroxetine44 50 28 1114.1COMT, HTR2A, DRD3
10apomorphine28 44 1113.1HTR2A, DRD3, COMT
11bromocriptine44 28 1113.1DRD3, COMT, HTR2A
12risperidone44 50 28 60 24 1116.1COMT, HTR2A, DRD3
13olanzapine44 50 28 24 1115.1DRD3, COMT, HTR2A
14proline4411.1DAOA, NRG1, DAO, COMT
15levodopa44 1112.1COMT, MTHFR, DRD3
16clozapine44 28 50 1114.1DRD3, COMT, HTR2A
17amisulpride44 28 1113.0DRD3, HTR2A
18s330842811.0DRD3, HTR2A
19(+)-butaclamol44 2812.0DRD3, HTR2A
20remoxipride44 1112.0HTR2A, DRD3
21duloxetine44 50 28 1114.0HTR2A, DRD3
22raclopride44 2812.0DRD3, HTR2A
23roxindole28 4412.0HTR2A, DRD3
24terguride44 2812.0HTR2A, DRD3
25spiperone44 2812.0HTR2A, DRD3
26dopac4411.0COMT, DRD3
27piperazine44 1112.0HTR2A, DRD3
28amantadine44 1112.0COMT, DRD3
29carbon4410.9DAO, COMT, MTHFR
30pimozide28 44 50 1113.9DRD3, HTR2A
31maoa4410.9HTR2A, COMT
32lisuride44 28 1112.9HTR2A, DRD3
33paliperidone44 1111.9DRD3, HTR2A
34iloperidone50 44 28 1113.9HTR2A, DRD3
35quinpirole44 2811.9HTR2A, DRD3
36fluvoxamine44 50 1112.9COMT, HTR2A
37venlafaxine44 50 24 1113.8COMT, HTR2A
38valine4410.8MTHFR, COMT, DAO
39asenapine28 1111.8HTR2A, DRD3
40riboflavin44 24 1112.8DAO, MTHFR
41heroin44 50 1112.7COMT, DRD3
42aripiprazole28 44 50 24 1114.7HTR2A, DRD3
43yohimbine44 1 28 1113.6HTR2A, DRD3
44l-amino acid4410.6COMT, DAO
45ziprasidone28 50 44 1113.5DRD3, HTR2A
46bupropion50 44 24 1113.3COMT, DRD3

GO Terms for genes affiliated with Schizophrenia

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Biological processes related to Schizophrenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:004249310.8DRD3, COMT, HTR2A, MTHFR
2regulation of dopamine secretionGO:001405910.7DRD3, HTR2A
3learningGO:000761210.6DRD3, COMT
4behavioral response to cocaineGO:004814810.5HTR2A, DRD3
5response to interleukin-1GO:007055510.3MTHFR, CHI3L1

Sources for Schizophrenia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet