MCID: SCH015
MIFTS: 82

Schizophrenia malady

Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases categories
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Summaries for Schizophrenia

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Schizophrenia is a serious brain illness. people who have it may hear voices that aren't there. they may think other people are trying to hurt them. sometimes they don't make sense when they talk. the disorder makes it hard for them to keep a job or take care of themselves. symptoms of schizophrenia usually start between ages 16 and 30. men often develop symptoms at a younger age than women. people usually do not get schizophrenia after age 45. there are three types of symptoms: psychotic symptoms distort a person's thinking. these include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements. "negative" symptoms make it difficult to show emotions and to function normally. a person may seem depressed and withdrawn. cognitive symptoms affect the thought process. these include trouble using information, making decisions, and paying attention. no one is sure what causes schizophrenia. your genes, environment, and brain chemistry may play a role. there is no cure. medicine can help control many of the symptoms. you may need to try different medicines to see which works best. you should stay on your medicine for as long as your doctor recommends. additional treatments can help you deal with your illness from day to day. these include therapy, family education, rehabilitation, and skills training. nih: national institute of mental health

MalaCards: Schizophrenia, also known as schizophrenia, susceptibility to, is related to bipolar disorder and schizoaffective disorder. An important gene associated with Schizophrenia is DISC1 (disrupted in schizophrenia 1), and among its related pathways is Monoamine GPCRs. The drugs carbamazepine and chlorpromazine and the compounds dopamine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.

Wikipedia:65 Schizophrenia (/?sk?ts??fr?ni?/ or /?sk?ts??fri?ni?/) is a mental disorder often characterized by... more...

Description from OMIM:47 181500,604906,603013

Aliases & Classifications for Schizophrenia

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8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 20GeneTests, 22GTR, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

schizophrenia 8 9 47 10 45 34 62
schizophrenia, susceptibility to 9 20 22
schizophrenia-1 8
schizophrenia 1 62


External Ids:

Disease Ontology8 DOID:5419
MeSH35 D012559
ICD9CM27 295.8, 295.80
OMIM47 181500
ICD1025 F20, F20.9

Related Diseases for Schizophrenia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Schizophrenia family:

Schizophrenia 4 Schizophrenia 12
Schizophrenia 17 Schizophrenia 14
Schizophrenia 16 Schizophrenia 13
Schizophrenia 10 Schizophrenia 15
Early-Onset Schizophrenia

Diseases related to Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 345)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.9DISC1, DTNBP1, HTR2A, DRD3, NRG1, COMT
2schizoaffective disorder31.9TAAR6, DAOA, DISC1, DTNBP1, HTR2A, COMT
3mood disorder31.2NRG1, DRD3, HTR2A, DISC1, DAOA, COMT
4psychotic disorder30.9COMT, DAOA, HTR2A, NRG1, DRD3, DISC1
5obsessive-compulsive disorder30.9HTR2A, COMT, DRD3
6alzheimer's disease30.8NRG1, COMT, HTR2A, DRD3, RTN4R
7antisocial personality disorder30.8HTR2A
8attention deficit hyperactivity disorder30.7HTR2A, COMT
9panic disorder30.5COMT, HTR2A
10substance dependence30.5DRD3, COMT
11alcohol abuse30.5DRD3, COMT
12narcolepsy30.4COMT, HTR2A
13pathological gambling30.3DRD3
14anxiety disorder30.2COMT, HTR2A
15eating disorder30.1HTR2A, COMT
16gilles de la tourette syndrome29.9HTR2A, COMT, DRD3
17generalized anxiety disorder29.9HTR2A
18paranoid schizophrenia11.0
19childhood-onset schizophrenia10.9
20early-onset schizophrenia10.9
21tardive dyskinesia10.8
22neuronitis10.8
23blindness10.8
24personality disorder10.6
25cerebritis10.6
26bipolar i disorder10.6
27schizophreniform disorder10.5
28major depressive disorder10.5
29schizotypal personality disorder10.5
30dementia10.5
31brain disease10.4
32delusional disorder10.4
33hyperprolactinemia10.4
34substance abuse10.4
35memory impairment10.4
36autism spectrum disorder10.4
37borna disease10.3
38nicotine dependence10.3
39alcohol dependence10.3
40learning disability10.3
41obesity10.3
42cerebral atrophy10.3
43mutism10.3
44parkinson's disease10.3
45insulin resistance10.3
46klinefelter's syndrome10.3
47cannabis abuse10.3
48frontotemporal dementia10.3
49schizotaxia10.3
50mental retardation10.3

Graphical network of the top 20 diseases related to Schizophrenia:



Diseases related to schizophrenia

Symptoms for Schizophrenia

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

181500

Clinical features from OMIM:

181500,604906,603013

Genetic Tests for Schizophrenia

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Schizophrenia:

id Genetic test Affiliating Genes
1 Schizophrenia20 22 TAAR6

Anatomical Context for Schizophrenia

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33MalaCards
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MalaCards organs/tissues related to Schizophrenia:

33
Brain, Cortex, Prefrontal cortex, Testes, Eye, Temporal lobe, Cingulate cortex, Thalamus, Amygdala, Cerebellum, Pituitary, Bone, Lung, Olfactory bulb, Endothelial, T cells, Heart, Monocytes, Caudate nucleus, Thyroid, Whole blood, Hypothalamus, Liver, Skin, Nk cells, Breast, Prostate, Myeloid, Fetal brain

Animal Models for Schizophrenia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Schizophrenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.0DAO, RTN4R, DISC1, DTNBP1, MTHFR, COMT
2MP:000538611.0HTR2A, DISC1, DTNBP1, DAO, SYN2, COMT
3MP:000363110.7NRG1, DRD3, COMT, SYN2, MTHFR, DISC1

Publications for Schizophrenia

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Sources:
52PubMed
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Articles related to Schizophrenia:

(show top 50)    (show all 5784)
idTitleAuthorsYear
1
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
2
Modeling Heterogeneous Patients with a Clinical Diagnosis of Schizophrenia with Induced Pluripotent Stem Cells. (24331955)
2013
3
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
4
Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. (23301017)
2013
5
Paradoxical downregulation of HLA-A expression by IFNI^ associated with schizophrenia and noncoding genes. (23083632)
2013
6
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
7
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
8
Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia. (22094384)
2012
9
Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. (21850710)
2011
10
Association study of the frizzled 3 gene with Chinese Va schizophrenia. (22027177)
2011
11
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. (20603450)
2010
12
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
13
Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. (19892407)
2010
14
Schizophrenia, brain disease and meta-analyses: integrating the pieces and testing Fusar-Poli's hypothesis. (19651477)
2010
15
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. (19844207)
2010
16
Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. (18553389)
2009
17
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (18394866)
2008
18
Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. (17898419)
2008
19
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
20
Molecular mechanisms of schizophrenia. (17982252)
2007
21
Association analysis of AKT1 and schizophrenia in a UK case control sample. (17383860)
2007
22
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
23
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
24
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). (16828464)
2006
25
Associations between serum brain-derived neurotrophic factor levels and clinical phenotypes in schizophrenia patients. (16386272)
2006
26
Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. (16446740)
2006
27
Interpreting the association between cannabis use and increased risk for schizophrenia. (16060598)
2005
28
Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. (16086287)
2005
29
Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. (15647480)
2005
30
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
31
Family-based association study of synapsin II and schizophrenia. (15449241)
2004
32
Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia. (15081577)
2004
33
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (12815740)
2003
34
Association of the hSERT and SLC6A4 polymorphic markers of the serotonin transporter gene with schizophrenia in different ethnic groups]. (12942632)
2003
35
Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. (12746393)
2003
36
Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. (11920853)
2002
37
Quetiapine-induced improvement of tardive dyskinesia in three patients with schizophrenia. (12177588)
2002
38
Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry. (11793166)
2002
39
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
40
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
41
Schizophrenia and schizoaffective disorder treated with high doses of olanzapine. (10350037)
1999
42
The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. (10067950)
1999
43
Change in plasma prolactin and clinical response to haloperidol in schizophrenia and schizoaffective disorder. (9829650)
1998
44
Initial 'schizophrenia-like' psychosis in Pick's disease: case study with neuroimaging and neuropathology, and implications for frontotemporal dysfunction in schizophrenia. (8929764)
1995
45
Sydenham's chorea and schizophrenia: a case report. (7547648)
1995
46
Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. (8094629)
1993
47
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
48
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
49
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Schizophrenia

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Expression for genes affiliated with Schizophrenia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schizophrenia

Search GEO for disease gene expression data for Schizophrenia.

Pathways for genes affiliated with Schizophrenia

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7TAAR6, DRD3, HTR2A

Compounds for genes affiliated with Schizophrenia

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Schizophrenia according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 24 1114.6DRD3, COMT, HTR2A, MTHFR, DAOA, DTNBP1
2glutamate4511.4DAO, NRG1, MTHFR, DRD3, COMT, DTNBP1
3nmda45 2912.3DAOA, DAO, COMT, DRD3, NRG1
4proline4511.2COMT, NRG1, DTNBP1, DAOA, DAO
5clozapine45 29 51 1114.2DTNBP1, DRD3, COMT, HTR2A
6antipsychotics5111.1COMT, MTHFR, HTR2A
7ropinirole45 1112.1HTR2A, COMT, DRD3
8pergolide45 29 1113.1COMT, DRD3, HTR2A
9pramipexole45 29 51 1114.1DRD3, HTR2A, COMT
10cabergoline45 29 1113.1COMT, HTR2A, DRD3
11paroxetine45 51 29 1114.1COMT, HTR2A, DRD3
12apomorphine29 45 1113.1HTR2A, COMT, DRD3
13bromocriptine45 29 1113.1HTR2A, COMT, DRD3
14risperidone45 51 29 61 24 1116.1COMT, HTR2A, DRD3
15methamphetamine45 51 1113.1COMT, DRD3, DTNBP1
16olanzapine45 51 29 24 1115.1HTR2A, DRD3, COMT
17levodopa45 1112.1DRD3, MTHFR, COMT
18haloperidol45 51 29 3 1115.0DTNBP1, HTR2A, DRD3
19amisulpride45 29 1113.0HTR2A, DRD3
20s330842911.0HTR2A, DRD3
21(+)-butaclamol45 2912.0DRD3, HTR2A
22remoxipride45 1112.0DRD3, HTR2A
23duloxetine45 51 29 1114.0HTR2A, DRD3
24raclopride45 2912.0DRD3, HTR2A
25roxindole29 4512.0HTR2A, DRD3
26terguride45 2912.0DRD3, HTR2A
27piperazine45 1112.0DRD3, HTR2A
28spiperone45 2912.0DRD3, HTR2A
29dopac4511.0COMT, DRD3
30amantadine45 1111.9COMT, DRD3
31carbon4510.9COMT, MTHFR, DAO
32pimozide29 45 51 1113.9DRD3, HTR2A
33maoa4510.9HTR2A, COMT
34lisuride45 29 1112.9DRD3, HTR2A
35paliperidone45 1111.9HTR2A, DRD3
36iloperidone51 45 29 1113.9HTR2A, DRD3
37quinpirole45 2911.9DRD3, HTR2A
38fluvoxamine45 51 1112.9HTR2A, COMT
39asenapine29 1111.8DRD3, HTR2A
40valine4510.8MTHFR, COMT, DAO
41riboflavin45 24 1112.8MTHFR, DAO
42venlafaxine45 51 24 1113.8HTR2A, COMT
43heroin45 51 1112.7DRD3, COMT
44aripiprazole29 45 51 24 1114.7DRD3, HTR2A
45yohimbine45 3 29 1113.6HTR2A, DRD3
46l-amino acid4510.6COMT, DAO
47bupropion51 45 24 1113.5COMT, DRD3
48ziprasidone29 51 45 1113.3HTR2A, DRD3

GO Terms for genes affiliated with Schizophrenia

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16Gene Ontology
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Cellular components related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.7NRG1, HTR2A, DTNBP1

Biological processes related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.7DRD3, HTR2A, DTNBP1
2response to drugGO:04249310.7MTHFR, HTR2A, COMT, DRD3
3response to interleukin-1GO:07055510.6MTHFR, CHI3L1
4behavioral response to cocaineGO:04814810.3DRD3, HTR2A

Products for genes affiliated with Schizophrenia

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Sources for Schizophrenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet