MCID: SCH015
MIFTS: 77

Schizophrenia malady

Neuronal diseases category

Summaries for Schizophrenia

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Schizophrenia is a serious brain illness. people who have it may hear voices that aren't there. they may think other people are trying to hurt them. sometimes they don't make sense when they talk. the disorder makes it hard for them to keep a job or take care of themselves. symptoms of schizophrenia usually start between ages 16 and 30. men often develop symptoms at a younger age than women. people usually do not get schizophrenia after age 45. there are three types of symptoms: psychotic symptoms distort a person's thinking. these include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements. "negative" symptoms make it difficult to show emotions and to function normally. a person may seem depressed and withdrawn. cognitive symptoms affect the thought process. these include trouble using information, making decisions, and paying attention. no one is sure what causes schizophrenia. your genes, environment, and brain chemistry may play a role. there is no cure. medicine can help control many of the symptoms. you may need to try different medicines to see which works best. you should stay on your medicine for as long as your doctor recommends. additional treatments can help you deal with your illness from day to day. these include therapy, family education, rehabilitation, and skills training. nih: national institute of mental health

MalaCards: Schizophrenia, also known as schizophrenia, susceptibility to, is related to bipolar disorder and schizoaffective disorder. An important gene associated with Schizophrenia is DISC1 (disrupted in schizophrenia 1), and among its related pathways is Monoamine GPCRs. The drugs selegiline and selegiline hydrochloride and the compounds dopamine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotype behavior/neurological.

Disease Ontology:8 A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.

Wikipedia:63 Schizophrenia (/ˌskɪtsɵˈfrɛniə/ or /ˌskɪtsɵˈfriːniə/) is a mental disorder characterized by... more...

Description from OMIM:46 181500,604906,603013

Aliases & Classifications for Schizophrenia

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Sources:
8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

schizophrenia 8 9 46 10 44 33 60
schizophrenia, susceptibility to 9 20 22
schizophrenia-1 8
schizophrenia 1 60


External Ids:

Disease Ontology8 DOID:5419
OMIM46 181500
ICD9CM27 295.8, 295.80
MeSH34 D012559
ICD1025 F20, F20.9

Related Diseases for Schizophrenia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Schizophrenia family:

Schizophrenia 4 Schizophrenia 12
Schizophrenia 17 Schizophrenia 14
Schizophrenia 16 Schizophrenia 13
Schizophrenia 10 Schizophrenia 15
Early-Onset Schizophrenia

Diseases related to Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.6COMT, DTNBP1, HTR2A, DRD3, DISC1, NRG1
2schizoaffective disorder31.5COMT, DTNBP1, HTR2A, DRD3, DISC1, TAAR6
3mood disorder30.9COMT, HTR2A, DRD3, DISC1, NRG1, DAOA
4bipolar i disorder30.8DTNBP1
5psychotic disorder30.8COMT, DTNBP1, HTR2A, DRD3, DISC1, NRG1
6dementia30.6HTR2A, COMT
7obsessive-compulsive disorder30.6DRD3, HTR2A, COMT
8alcohol dependence30.5HTR2A
9attention deficit hyperactivity disorder30.5HTR2A, COMT
10antisocial personality disorder30.4HTR2A
11alcohol abuse30.2COMT, DRD3
12panic disorder30.2COMT, HTR2A
13substance dependence30.2DRD3, COMT
14multiple sclerosis30.0RTN4R, NRG1, COMT
15gilles de la tourette syndrome29.6DRD3, HTR2A, COMT
16paranoid schizophrenia11.0
17neuronitis10.7
18personality disorder10.6
19major depressive disorder10.6
20cerebritis10.6
21schizophreniform disorder10.5
22schizotypal personality disorder10.5
23brain disease10.5
24delusional disorder10.4
25substance abuse10.4
26hyperprolactinemia10.4
27alzheimer's disease10.3
28autism spectrum disorder10.3
29borna disease10.3
30nicotine dependence10.3
31childhood-onset schizophrenia10.3
32obesity10.3
33mitochondrial disorders10.3
34cannabis abuse10.3
35learning disability10.3
36parkinson's disease10.2
37mutism10.2
38klinefelter's syndrome10.2
39frontotemporal dementia10.2
40cocaine dependence10.2
41conduct disorder10.2
42anxiety disorder10.2
43sexual disorder10.2
44narcolepsy10.1
45alexithymia10.1
46diabetes mellitus10.1
47speech disorder10.1
48type 2 diabetes mellitus10.1
49schizophrenia 410.1
50marfan syndrome10.0

Graphical network of the top 20 diseases related to Schizophrenia:



Diseases related to schizophrenia

Clinical Features for Schizophrenia

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Sources:
46OMIM
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Clinical features from OMIM:

181500,604906,603013

Clinical synopsis from OMIM:

181500

Genetic Tests for Schizophrenia

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Schizophrenia:

id Genetic test Affiliating Genes
1 Schizophrenia20 22 TAAR6

Anatomical Context for Schizophrenia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Schizophrenia:

32
Brain, Cortex, Prefrontal cortex, Testes, Eye, Temporal lobe, Cingulate cortex, Thalamus, Amygdala, Cerebellum, Pituitary, Bone, Lung, Olfactory bulb, Endothelial, T cells, Heart, Monocytes, Caudate nucleus, Thyroid, Whole blood, Hypothalamus, Liver, Skin, Nk cells, Breast, Prostate, Myeloid, Fetal brain

Animal Models for Schizophrenia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538612.4RTN4R, DAO, NRG1, SYN2, DISC1, DRD3

Publications for Schizophrenia

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Sources:
50PubMed
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Articles related to Schizophrenia:

(show top 50)    (show all 5836)
idTitleAuthorsYear
1
Prevalence of cardiovascular risk factors among racial and ethnic minorities with schizophrenia spectrum and bipolar disorders: a critical literature review. (24269193)
2014
2
CNVs conferring risk of autism or schizophrenia affect cognition in controls. (24352232)
2014
3
Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder. (24401535)
2014
4
Self-reported Ambivalence in Schizophrenia and Associations With Negative Mood. (24375215)
2014
5
Prenatal genetic testing with chromosomal microarray analysis identifies major risk variants for schizophrenia and other later-onset disorders. (24306343)
2013
6
Impaired Rich Club Connectivity in Unaffected Siblings of Schizophrenia Patients. (24298172)
2013
7
How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia. (22938164)
2013
8
The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations. (23029143)
2012
9
Association of thrombospondin 1 gene with schizophrenia in Korean population. (22311024)
2012
10
Lack of association between proline dehydrogenase (oxidase) 1 polymorphisms and schizophrenia in a Korean population. (21960278)
2012
11
Leukemia inhibitory factor gene is associated with schizophrenia and working memory function. (19879916)
2010
12
Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. (20580759)
2010
13
Determinants of work outcome in schizophrenia and schizoaffective disorder: role of cognitive function. (19646764)
2009
14
A two-stage case-control association study of PADI2 with schizophrenia. (19478818)
2009
15
Serum immunological markers as predictors of effectiveness of antipsychotic therapy in patients with schizophrenia]. (18427517)
2008
16
Association of Sult4A1 SNPs with psychopathology and cognition in patients with schizophrenia or schizoaffective disorder. (18823757)
2008
17
Sex chromosome anomalies in childhood onset schizophrenia: an update. (18800051)
2008
18
Randomized controlled trial of cognitive behavioral social skills training for older people with schizophrenia: 12-month follow-up. (17503982)
2007
19
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. (17440435)
2007
20
The incidence of clozapine-induced leukopenia in patients with schizophrenia at Srinagarind Hospital. (18041439)
2007
21
Maintenance therapy with once-monthly administration of long-acting injectable risperidone in patients with schizophrenia or schizoaffective disorder: a pilot study of an extended dosing interval. (17261186)
2007
22
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. (16533563)
2006
23
Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. (16754835)
2006
24
Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia. (16292589)
2006
25
Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia. (16490177)
2006
26
Distribution of androgen receptor CAG repeat polymorphism in Chinese schizophrenia and its correlation with age at onset. (16112495)
2006
27
Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia. (16632332)
2006
28
Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression. (16246257)
2005
29
Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene]. (15696493)
2005
30
DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. (15930386)
2005
31
Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (15963589)
2005
32
Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia. (15291683)
2004
33
Interaction between NOTCH4 and catechol-O-methyltransferase genotypes in schizophrenia patients with poor response to typical neuroleptics. (15115916)
2004
34
Genetic approaches to polydipsia in schizophrenia: a preliminary report of a family study and an association study of an angiotensin-converting enzyme gene polymorphism. (12707930)
2003
35
A-1438-G serotonin receptor type 2A (5-HTR2A) gene polymorphism in patients in patients with schizophrenia]. (12830506)
2003
36
CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. (12497613)
2003
37
Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset. (12670706)
2003
38
Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. (12497610)
2003
39
A highly significant association between a COMT haplotype and schizophrenia. (12402217)
2002
40
Schizophrenia and dopamine D4 gene polymorphism in Chinese population: association analysis]. (11718085)
2001
41
Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples. (11807411)
2001
42
Failure to establish linkage on the X chromosome in 301 families with schizophrenia or schizoaffective disorder. (10898911)
2000
43
Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. (11204352)
2000
44
Novel polymorphism in the gene region encoding the carboxyl-terminal intracellular domain of the NMDA receptor 2B subunit: analysis of association with schizophrenia. (10910800)
2000
45
The prevalence of comorbid anxiety in schizophrenia, schizoaffective disorder and bipolar disorder. (9565185)
1998
46
A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. (9577838)
1998
47
Increased production of interleukin-2 (IL-2) but not soluble interleukin-2 receptors (sIL-2R) in unmedicated patients with schizophrenia and schizophreniform disorder. (9029665)
1996
48
CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. (8185172)
1994
49
Exclusion of linkage between schizophrenia and the D2 dopamine receptor gene region of chromosome 11q in 112 Irish multiplex families. (8439241)
1993
50
Conception of masculine and feminine roles in paranoid schizophrenia. (13346676)
1956

Genetic Variations for Schizophrenia

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Expression for genes affiliated with Schizophrenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schizophrenia

Search GEO for disease gene expression data for Schizophrenia.

Pathways for genes affiliated with Schizophrenia

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB
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Pathways related to Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1TAAR6, DRD3, HTR2A

Compounds for genes affiliated with Schizophrenia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Schizophrenia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2415.8DAO, COMT, DTNBP1, HTR2A, DRD3, DISC1
2glutamate4412.4COMT, DTNBP1, DRD3, MTHFR, NRG1, DAOA
3proline4411.9COMT, DTNBP1, NRG1, DAOA, DAO
4clozapine44 28 49 1114.8COMT, DTNBP1, HTR2A, DRD3
5ropinirole44 1112.5DRD3, HTR2A, COMT
6pergolide28 44 1113.5COMT, HTR2A, DRD3
7pramipexole44 49 28 1114.5DRD3, HTR2A, COMT
8cabergoline28 44 1113.5DRD3, HTR2A, COMT
9nmda44 2812.5COMT, DAOA, DAO
10paroxetine44 49 28 1114.5DRD3, HTR2A, COMT
11apomorphine44 28 1113.5COMT, HTR2A, DRD3
12risperidone28 44 49 59 11 2416.5DRD3, HTR2A, COMT
13bromocriptine28 44 1113.5DRD3, HTR2A, COMT
14methamphetamine44 49 1113.5COMT, DTNBP1, DRD3
15olanzapine49 44 28 11 2415.5DRD3, HTR2A, COMT
16levodopa44 1112.4COMT, DRD3, MTHFR
17haloperidol44 28 2 49 1115.4DTNBP1, HTR2A, DRD3
18amisulpride44 28 1113.3DRD3, HTR2A
19s330842811.3DRD3, HTR2A
20(+)-butaclamol28 4412.3HTR2A, DRD3
21antipsychotics4911.3MTHFR, COMT
22remoxipride44 1112.3DRD3, HTR2A
23duloxetine44 49 28 1114.2HTR2A, DRD3
24raclopride44 2812.2DRD3, HTR2A
25roxindole28 4412.2DRD3, HTR2A
26Chlorprothixene1111.2DRD3, HTR2A
27terguride28 4412.2DRD3, HTR2A
28spiperone28 4412.2DRD3, HTR2A
29dopac4411.2DRD3, COMT
30piperazine44 1112.1DRD3, HTR2A
31amantadine44 1112.1COMT, DRD3
32maoa4411.1HTR2A, COMT
33pimozide28 49 44 1114.1DRD3, HTR2A
34lisuride28 44 1113.1HTR2A, DRD3
35paliperidone44 1112.0DRD3, HTR2A
36Methotrimeprazine1111.0HTR2A, DRD3
37iloperidone49 44 28 1113.9HTR2A, DRD3
38asenapine28 1111.9DRD3, HTR2A
39quinpirole44 2811.8DRD3, HTR2A
40riboflavin44 11 2412.6DAO, MTHFR

GO Terms for genes affiliated with Schizophrenia

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16Gene Ontology
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Biological processes related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405911.1DRD3, HTR2A, DTNBP1

Products for genes affiliated with Schizophrenia

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Sources for Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet