MCID: SCH015
MIFTS: 82

Schizophrenia malady

Genetic diseases (common), Mental diseases categories
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Summaries for Schizophrenia

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MedlinePlus:33 Schizophrenia is a serious brain illness. people who have it may hear voices that aren't there. they may think other people are trying to hurt them. sometimes they don't make sense when they talk. the disorder makes it hard for them to keep a job or take care of themselves. symptoms of schizophrenia usually start between ages 16 and 30. men often develop symptoms at a younger age than women. people usually do not get schizophrenia after age 45. there are three types of symptoms: psychotic symptoms distort a person's thinking. these include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements. "negative" symptoms make it difficult to show emotions and to function normally. a person may seem depressed and withdrawn. cognitive symptoms affect the thought process. these include trouble using information, making decisions, and paying attention. no one is sure what causes schizophrenia. your genes, environment, and brain chemistry may play a role. there is no cure. medicine can help control many of the symptoms. you may need to try different medicines to see which works best. you should stay on your medicine for as long as your doctor recommends. additional treatments can help you deal with your illness from day to day. these include therapy, family education, rehabilitation, and skills training. nih: national institute of mental health

MalaCards based summary: Schizophrenia, also known as schizophrenia, susceptibility to, is related to bipolar disorder and schizoaffective disorder, and has symptoms including An important gene associated with Schizophrenia is DISC1 (disrupted in schizophrenia 1), and among its related pathways is Monoamine GPCRs. The drugs selegiline and selegiline hydrochloride and the compounds dopamine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Disease Ontology:8 A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.

Wikipedia:65 Schizophrenia (/?sk?ts??fr?ni?/ or /?sk?ts??fri?ni?/) is a mental disorder often characterized by... more...

Descriptions from OMIM:46 181500,604906,603013

Aliases & Classifications for Schizophrenia

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Schizophrenia, Aliases & Descriptions:

Name: Schizophrenia 30 8 9 46 10 44 33 62
Schizophrenia, Susceptibility to 9 20 22
 
Schizophrenia-1 8
Schizophrenia 1 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:5419
MeSH34 D012559
ICD9CM27 295.8, 295.80
OMIM46 181500
ICD1025 F20, F20.9

Related Diseases for Schizophrenia

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Diseases in the Schizophrenia family:

Schizophrenia 4 Schizophrenia 12
Schizophrenia 17 Schizophrenia 14
Schizophrenia 16 Schizophrenia 13
Schizophrenia 10 Schizophrenia 15

Diseases related to Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder32.8DAOA, DAO, DISC1, DTNBP1, HTR2A, COMT
2schizoaffective disorder32.8DAOA, DISC1, DTNBP1, HTR2A, COMT, DRD3
3mood disorder32.1DAOA, DISC1, HTR2A, COMT, DRD3, NRG1
4psychotic disorder31.9DAOA, DISC1, DTNBP1, HTR2A, COMT, DRD3
5obsessive-compulsive disorder31.7DRD3, COMT, HTR2A
6alzheimer's disease31.6NRG1, DRD3, COMT, HTR2A, RTN4R
7antisocial personality disorder31.5HTR2A
8substance dependence31.2COMT, DRD3
9panic disorder31.2COMT, HTR2A
10alcohol abuse31.1DRD3, COMT
11attention deficit hyperactivity disorder31.1COMT, HTR2A
12narcolepsy31.1COMT, HTR2A
13pathological gambling31.1DRD3
14anxiety disorder30.9COMT, HTR2A
15eating disorder30.8COMT, HTR2A
16gilles de la tourette syndrome30.7DRD3, COMT, HTR2A
17generalized anxiety disorder30.6HTR2A
18paranoid schizophrenia11.0
19childhood-onset schizophrenia10.9
20tardive dyskinesia10.8
21neuronitis10.8
22blindness10.8
23migraine10.7MTHFR, HTR2A, COMT, DRD3
24personality disorder10.7
25bulimia nervosa10.6COMT, HTR2A
26cerebritis10.6
27fibromyalgia10.6COMT, HTR2A
28bipolar i disorder10.6
29essential tremor10.6DRD3
30schizophreniform disorder10.6
31major depressive disorder10.5
32schizotypal personality disorder10.5
33malignant glioma10.5NRG1, COMT, HTR2A, CHI3L1
34dementia10.5
35stroke, ischemic10.5MTHFR, NRG1
36brain disease10.4
37hyperprolactinemia10.4
38delusional disorder10.4
39autism spectrum disorder10.4
40substance abuse10.4
41memory impairment10.4
42borna disease10.4
43cannabis abuse10.4
44nicotine dependence10.4
45alcohol dependence10.3
46obesity10.3
47learning disability10.3
48cerebral atrophy10.3
49insulin resistance10.3
50parkinson's disease10.3

Graphical network of the top 20 diseases related to Schizophrenia:



Diseases related to schizophrenia

Symptoms for Schizophrenia

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Symptoms by clinical synopsis from OMIM:

181500

Clinical features from OMIM:

181500,604906,603013

HPO human phenotypes related to Schizophrenia:

(show all 21)
id Description Frequency HPO Source Accession
1 eeg abnormality 25% HP:0002353
2 autosomal dominant inheritance HP:0000006
3 hallucinations HP:0000738
4 delusions HP:0000746
5 heterogeneous HP:0001425
6 social and occupational deterioration HP:0007086
7 schizophrenia HP:0100753
8 autosomal dominant inheritance HP:0000006
9 ectopic kidney HP:0000086
10 renal agenesis HP:0000104
11 hypertelorism HP:0000316
12 protruding ear HP:0000411
13 hallucinations HP:0000738
14 delusions HP:0000746
15 frontal bossing HP:0002007
16 short stature HP:0004322
17 flat occiput HP:0005469
18 social and occupational deterioration HP:0007086
19 partially duplicated kidney HP:0008738
20 short proximal phalanx of the 4th toe HP:0100396
21 schizophrenia HP:0100753

Genetic Tests for Schizophrenia

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Genetic tests related to Schizophrenia:

id Genetic test Affiliating Genes
1 Schizophrenia20 22 TAAR6

Anatomical Context for Schizophrenia

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MalaCards organs/tissues related to Schizophrenia:

32
Brain, Cortex, Prefrontal cortex, Testes, Eye, Cingulate cortex, Temporal lobe, Thalamus, Amygdala, Cerebellum, Pituitary, Bone, Endothelial, Heart, Lung, Olfactory bulb, Caudate nucleus, Whole blood, Thyroid, Monocytes, T cells, Liver, Breast, Skin, Prostate, Myeloid, Nk cells, Hypothalamus, Fetal brain

Animal Models for Schizophrenia or affiliated genes

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MGI Mouse Phenotypes related to Schizophrenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.0DAO, RTN4R, DISC1, DTNBP1, MTHFR, COMT
2MP:000538611.0HTR2A, DISC1, DTNBP1, DAO, SYN2, COMT
3MP:000363110.7NRG1, DRD3, COMT, SYN2, MTHFR, DISC1

Publications for Schizophrenia

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Articles related to Schizophrenia:

(show top 50)    (show all 5968)
idTitleAuthorsYear
1
Structural brain alterations associated with schizophrenia preceded by conduct disorder: a common and distinct subtype of schizophrenia? (23015687)
2013
2
Modeling Heterogeneous Patients with a Clinical Diagnosis of Schizophrenia with Induced Pluripotent Stem Cells. (24331955)
2013
3
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
4
Revisiting disrupted-in-schizophrenia 1 as a scaffold protein. (23832957)
2013
5
Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. (23301017)
2013
6
Paradoxical downregulation of HLA-A expression by IFNI^ associated with schizophrenia and noncoding genes. (23083632)
2013
7
Assessment of real-world daily-living skills in early-onset schizophrenia trough the Life Skills Profile scale. (23384737)
2013
8
Are cardiovascular risk factors associated with verbal learning and memory impairment in patients with schizophrenia? A cross-sectional study. (23227310)
2012
9
Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia. (22094384)
2012
10
Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. (21850710)
2011
11
Association study of the frizzled 3 gene with Chinese Va schizophrenia. (22027177)
2011
12
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. (20603450)
2010
13
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
14
Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. (19892407)
2010
15
Schizophrenia, brain disease and meta-analyses: integrating the pieces and testing Fusar-Poli's hypothesis. (19651477)
2010
16
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. (19844207)
2010
17
DTNBP1 gene is associated with some symptom factors of schizophrenia in Chinese Han nationality. (20598229)
2010
18
Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. (18553389)
2009
19
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (18394866)
2008
20
Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. (17898419)
2008
21
Molecular mechanisms of schizophrenia. (17982252)
2007
22
Association analysis of AKT1 and schizophrenia in a UK case control sample. (17383860)
2007
23
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
24
Antipsychotic medication for childhood-onset schizophrenia. (17636744)
2007
25
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). (16828464)
2006
26
Associations between serum brain-derived neurotrophic factor levels and clinical phenotypes in schizophrenia patients. (16386272)
2006
27
Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. (16446740)
2006
28
Interpreting the association between cannabis use and increased risk for schizophrenia. (16060598)
2005
29
Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. (16086287)
2005
30
Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. (15647480)
2005
31
Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. (14992974)
2004
32
Family-based association study of synapsin II and schizophrenia. (15449241)
2004
33
Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia. (15081577)
2004
34
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (12815740)
2003
35
Association of the hSERT and SLC6A4 polymorphic markers of the serotonin transporter gene with schizophrenia in different ethnic groups]. (12942632)
2003
36
Quetiapine-induced improvement of tardive dyskinesia in three patients with schizophrenia. (12177588)
2002
37
Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry. (11793166)
2002
38
Olanzapine treatment for patients with schizophrenia and cocaine abuse. (12530415)
2002
39
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
40
Schizophrenia and schizoaffective disorder treated with high doses of olanzapine. (10350037)
1999
41
The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder. (10067950)
1999
42
Change in plasma prolactin and clinical response to haloperidol in schizophrenia and schizoaffective disorder. (9829650)
1998
43
Treatment of negative symptoms in schizophrenia and schizoaffective disorder by selegiline augmentation of antipsychotic medication. A pilot study examining the role of dopamine. (8627275)
1996
44
Initial 'schizophrenia-like' psychosis in Pick's disease: case study with neuroimaging and neuropathology, and implications for frontotemporal dysfunction in schizophrenia. (8929764)
1995
45
Sydenham's chorea and schizophrenia: a case report. (7547648)
1995
46
Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia. (8094629)
1993
47
Schizophrenia-like psychosis with Capgras syndrome in a patient with right temporal lobe epilepsy--a case report. (4095563)
1985
48
Motor and sighting dominance in schizophrenia and affective disorder. Evidence for right-hand grip strength prominence in paranoid schizophrenia and bipolar illness. (4016461)
1985
49
Cross-cultural study of a biochemical abnormality in paranoid schizophrenia. (6948314)
1981
50
The place of paranoid states in psychiatric classification with special reference to paranoid schizophrenia. (18875667)
1948

Variations for Schizophrenia

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Clinvar genetic disease variations for Schizophrenia:

6
id Gene Name Type Significance SNP ID Assembly Location
1DISC1DISC1, HAPLOTYPE, HEP3undetermined variantPathogenic

Expression for genes affiliated with Schizophrenia

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Expression patterns in normal tissues for genes affiliated with Schizophrenia

Search GEO for disease gene expression data for Schizophrenia.

Pathways for genes affiliated with Schizophrenia

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Pathways related to Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7TAAR6, DRD3, HTR2A

Compounds for genes affiliated with Schizophrenia

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Compounds related to Schizophrenia according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 24 1114.6NRG1, DAOA, DAO, DISC1, DTNBP1, MTHFR
2glutamate4411.4DAOA, DAO, DTNBP1, MTHFR, COMT, DRD3
3nmda44 2812.3DAOA, DAO, COMT, DRD3, NRG1
4proline4411.2DAOA, DAO, DTNBP1, COMT, NRG1
5clozapine44 28 50 1114.2DTNBP1, HTR2A, COMT, DRD3
6antipsychotics5011.1MTHFR, HTR2A, COMT
7ropinirole44 1112.1DRD3, COMT, HTR2A
8pergolide44 28 1113.1DRD3, COMT, HTR2A
9pramipexole44 28 50 1114.1DRD3, COMT, HTR2A
10cabergoline44 28 1113.1DRD3, COMT, HTR2A
11paroxetine44 50 28 1114.1HTR2A, COMT, DRD3
12apomorphine28 44 1113.1HTR2A, COMT, DRD3
13bromocriptine44 28 1113.1DRD3, COMT, HTR2A
14risperidone44 50 28 61 24 1116.1HTR2A, COMT, DRD3
15methamphetamine44 50 1113.1DRD3, COMT, DTNBP1
16olanzapine44 50 28 24 1115.1HTR2A, COMT, DRD3
17levodopa44 1112.1MTHFR, COMT, DRD3
18haloperidol44 50 28 2 1115.0DTNBP1, HTR2A, DRD3
19amisulpride44 28 1113.0DRD3, HTR2A
20s330842811.0DRD3, HTR2A
21(+)-butaclamol44 2812.0DRD3, HTR2A
22remoxipride44 1112.0DRD3, HTR2A
23duloxetine44 50 28 1114.0DRD3, HTR2A
24raclopride44 2812.0DRD3, HTR2A
25roxindole28 4412.0DRD3, HTR2A
26terguride44 2812.0DRD3, HTR2A
27spiperone44 2812.0HTR2A, DRD3
28piperazine44 1112.0HTR2A, DRD3
29dopac4411.0COMT, DRD3
30amantadine44 1111.9DRD3, COMT
31carbon4410.9DAO, MTHFR, COMT
32pimozide28 44 50 1113.9HTR2A, DRD3
33maoa4410.9HTR2A, COMT
34lisuride44 28 1112.9HTR2A, DRD3
35paliperidone44 1111.9DRD3, HTR2A
36iloperidone50 44 28 1113.9DRD3, HTR2A
37quinpirole44 2811.9DRD3, HTR2A
38fluvoxamine44 50 1112.9COMT, HTR2A
39asenapine28 1111.8HTR2A, DRD3
40valine4410.8DAO, MTHFR, COMT
41riboflavin44 24 1112.8DAO, MTHFR
42venlafaxine44 50 24 1113.8HTR2A, COMT
43heroin44 50 1112.7DRD3, COMT
44aripiprazole28 44 50 24 1114.7HTR2A, DRD3
45yohimbine44 2 28 1113.6DRD3, HTR2A
46l-amino acid4410.6DAO, COMT
47bupropion50 44 24 1113.5DRD3, COMT
48ziprasidone28 50 44 1113.3DRD3, HTR2A

GO Terms for genes affiliated with Schizophrenia

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Cellular components related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.7NRG1, HTR2A, DTNBP1

Biological processes related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.7DRD3, HTR2A, DTNBP1
2response to drugGO:04249310.7MTHFR, HTR2A, COMT, DRD3
3response to interleukin-1GO:07055510.6MTHFR, CHI3L1
4behavioral response to cocaineGO:04814810.3DRD3, HTR2A

Products for genes affiliated with Schizophrenia

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Sources for Schizophrenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet