MCID: SCH015
MIFTS: 69

Schizophrenia malady

Neuronal category

Summaries for Schizophrenia

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

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MedlinePlus:34 Schizophrenia is a serious brain illness. people who have it may hear voices that aren't there. they may think other people are trying to hurt them. sometimes they don't make sense when they talk. the disorder makes it hard for them to keep a job or take care of themselves. symptoms of schizophrenia usually start between ages 16 and 30. men often develop symptoms at a younger age than women. people usually do not get schizophrenia after age 45. there are three types of symptoms: psychotic symptoms distort a person's thinking. these include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements. "negative" symptoms make it difficult to show emotions and to function normally. a person may seem depressed and withdrawn. cognitive symptoms affect the thought process. these include trouble using information, making decisions, and paying attention. no one is sure what causes schizophrenia. your genes, environment, and brain chemistry may play a role. there is no cure. medicine can help control many of the symptoms. you may need to try different medicines to see which works best. you should stay on your medicine for as long as your doctor recommends. additional treatments can help you deal with your illness from day to day. these include therapy, family education, rehabilitation, and skills training. nih: national institute of mental health

MalaCards: Schizophrenia, also known as schizophrenia, susceptibility to, is related to bipolar disorder and schizoaffective disorder. An important gene associated with Schizophrenia is DISC1 (disrupted in schizophrenia 1), and among its related pathways is Monoamine GPCRs. The drugs selegiline and selegiline hydrochloride and the compounds dopamine and glutamate have been mentioned in the context of this disorder. Related mouse phenotype behavior/neurological.

Disease Ontology:8 A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.

Wikipedia:64 Schizophrenia (/ˌskɪtsɵˈfrɛniə/ or /ˌskɪtsɵˈfriːniə/) is a mental disorder characterized by... more...

Description from OMIM:47 181500,604906,603013

Aliases & Classifications for Schizophrenia

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 20GeneTests, 22GTR, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

schizophrenia 8 9 47 10 45 34 61
schizophrenia, susceptibility to 9 20 22
schizophrenia-1 8
schizophrenia 1 61


External Ids:

Disease Ontology8 DOID:5419
OMIM47 181500
ICD9CM27 295.8, 295.80
MeSH35 D012559
ICD1025 F20, F20.9

Related Diseases for Schizophrenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Schizophrenia family:

schizophrenia 4 schizophrenia 12
schizophrenia 17 schizophrenia 14
schizophrenia 16 schizophrenia 13
schizophrenia 10 schizophrenia 15
early-onset schizophrenia

Diseases related to Schizophrenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.6NRG1, DISC1, DRD3, HTR2A, DAOA, DTNBP1
2schizoaffective disorder31.6DTNBP1, DAOA, TAAR6, DISC1, DRD3, HTR2A
3bipolar i disorder31.2DTNBP1
4obsessive-compulsive disorder30.6COMT, HTR2A, DRD3
5alcohol dependence30.5HTR2A
6attention deficit hyperactivity disorder30.5HTR2A, COMT
7antisocial personality disorder30.5HTR2A
8alcohol abuse30.3COMT, DRD3
9panic disorder30.3COMT, HTR2A
10substance dependence30.2DRD3, COMT
11paranoid schizophrenia11.0
12early-onset schizophrenia10.9
13childhood-onset schizophrenia10.9
14tardive dyskinesia10.8
15schizophreniform disorder10.5
16major depressive disorder10.5
17schizotypal personality disorder10.5
18brain disease10.5
19schizophrenia 1510.5
20schizophrenia 1010.4
21substance abuse10.4
22schizophrenia 1410.4
23hyperprolactinemia10.4
24alzheimer's disease10.4
25n syndrome10.4
26memory impairment10.4
27autism spectrum disorder10.3
28schizophrenia 1210.3
29borna disease10.3
30parkinson's disease10.3
31nicotine dependence10.3
32cannabis abuse10.3
33cerebral atrophy10.3
34insulin resistance10.3
35mutism10.3
36schizophrenia 410.3
37mental retardation10.3
38schizophrenia 1310.3
39klinefelter's syndrome10.2
40frontotemporal dementia10.2
41cocaine dependence10.2
42schizotaxia10.2
43conduct disorder10.2
44anxiety disorder10.2
45schizophrenia 1710.2
46narcolepsy10.2
47alexithymia10.2
48ataxia10.2
49brain injury10.2
50speech disorder10.1

Graphical network of the top 20 diseases related to Schizophrenia:



Diseases related to schizophrenia

Clinical Features for Schizophrenia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

181500,604906,603013

Clinical synopsis from OMIM:

181500

Genetic Tests for Schizophrenia

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Schizophrenia:

id Genetic test Affiliating Genes
1 Schizophrenia20 22 TAAR6

Anatomical Context for Schizophrenia

Animal Models for Schizophrenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Schizophrenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538612.4RTN4R, DAO, NRG1, SYN2, DISC1, DRD3

Publications for Schizophrenia

Sources:
51PubMed
See all sources

Articles related to Schizophrenia:

(show top 50)    (show all 5852)
idTitleAuthorsYear
1
The relationship between insight and theory of mind in schizophrenia. (24321712)
2014
2
Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA. (23423139)
2013
3
Reduced thalamic volume in men with antisocial personality disorder or schizophrenia and a history of serious violence and childhood abuse. (22944337)
2013
4
CE verbal episodic memory impairment in schizophrenia: a comparison with frontal lobe lesion patients. (23634645)
2013
5
Neuropsychological functioning and age-related changes in schizophrenia and/or cocaine dependence. (23123363)
2013
6
Reconceptualizing Schizophrenia. (24225692)
2013
7
Early nonresponse determined by the clinical global impressions scale predicts poorer outcomes in youth with schizophrenia spectrum disorders naturalistically treated with second-generation antipsychotics. (24266529)
2013
8
In Vivo Evidence for I^2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared with Nonsmokers with Schizophrenia. (24360979)
2013
9
Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. (23010486)
2012
10
KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. (22960338)
2012
11
The CNR1 gene in depression and schizophrenia - is there an association with early improvement and response? (22370152)
2012
12
Comparative effectiveness of second-generation antipsychotic medications in early-onset schizophrenia. (21307041)
2012
13
Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A. (21810628)
2011
14
SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders. (20800085)
2010
15
Serum bilirubin levels and UGT1A1 promoter variations in patients with schizophrenia. (20483464)
2010
16
Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (19346103)
2009
17
Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. (19054502)
2009
18
Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies. (18985292)
2008
19
Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. (18800054)
2008
20
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. (17434465)
2007
21
Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients. (16959057)
2007
22
Association study of GOT2 genetic polymorphisms and schizophrenia. (17728674)
2007
23
Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders. (16823382)
2007
24
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (17522711)
2007
25
Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. (17598910)
2007
26
Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication. (16932925)
2006
27
Sleep disturbances in childhood-onset schizophrenia. (16730952)
2006
28
Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia. (17012697)
2006
29
Correlates of substance abuse in adolescents with treatment-refractory schizophrenia and schizoaffective disorder. (15653284)
2005
30
IQ stabilization in childhood-onset schizophrenia. (15913958)
2005
31
Tardive dyskinesia associated with olanzapine in a neuroleptic-naive patient with schizophrenia. (15198472)
2004
32
A case of spinocerebellar ataxia 6 accompanied with schizophrenia]. (15024829)
2004
33
Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. (15465981)
2004
34
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. (15543516)
2004
35
No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia. (12960750)
2003
36
Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. (12474144)
2003
37
Correlation between fine motor activity and striatal dopamine D2 receptor density in patients with schizophrenia and healthy controls. (12928107)
2003
38
Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins. (12372661)
2002
39
The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs. (11743941)
2001
40
N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. (11532724)
2001
41
The effects of classic antipsychotic haloperidol plus the extract of ginkgo biloba on superoxide dismutase in patients with chronic refractory schizophrenia. (11721446)
1999
42
Working memory in childhood-onset schizophrenia and attention-deficit/hyperactivity disorder. (9754696)
1998
43
Research update: childhood-onset schizophrenia: implications of clinical and neurobiological research. (9534088)
1998
44
Interhemispheric EEG coherence in never-medicated patients with paranoid schizophrenia: analysis at rest and during photic stimulation. (9783090)
1998
45
First person account: paranoid schizophrenia--a daughter's story. (9502555)
1998
46
An association study between the Cys311 variant of dopamine D2 receptor gene and schizophrenia in the Okinawan population. (9472122)
1997
47
Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial. (9090331)
1997
48
An open-label study of the therapeutic efficacy of high-dose famotidine adjuvant pharmacotherapy in schizophrenia: preliminary evidence for treatment efficacy. (8828997)
1996
49
A study on serum prolactin levels in schizophrenia: correlation with positive and negative symptoms. (8263315)
1993
50
Schizophrenia scepticism. (1303244)
1992

Genetic Variations for Schizophrenia

Expression for genes affiliated with Schizophrenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Schizophrenia

Search GEO for disease gene expression data for Schizophrenia.

Pathways for genes affiliated with Schizophrenia

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB
See all sources

Pathways related to Schizophrenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1TAAR6, DRD3, HTR2A

Compounds for genes affiliated with Schizophrenia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Schizophrenia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2415.8DAO, COMT, DTNBP1, HTR2A, DRD3, DISC1
2glutamate4512.4COMT, DTNBP1, DRD3, MTHFR, NRG1, DAOA
3proline4511.9COMT, DTNBP1, NRG1, DAOA, DAO
4clozapine45 29 50 1114.8COMT, DTNBP1, HTR2A, DRD3
5ropinirole45 1112.5DRD3, HTR2A, COMT
6pergolide29 45 1113.5COMT, HTR2A, DRD3
7pramipexole45 50 29 1114.5DRD3, HTR2A, COMT
8cabergoline29 45 1113.5DRD3, HTR2A, COMT
9nmda45 2912.5COMT, DAOA, DAO
10paroxetine45 50 29 1114.5DRD3, HTR2A, COMT
11apomorphine45 29 1113.5COMT, HTR2A, DRD3
12risperidone29 45 50 60 11 2416.5DRD3, HTR2A, COMT
13bromocriptine29 45 1113.5DRD3, HTR2A, COMT
14methamphetamine45 50 1113.5COMT, DTNBP1, DRD3
15olanzapine50 45 29 11 2415.5DRD3, HTR2A, COMT
16levodopa45 1112.4COMT, DRD3, MTHFR
17haloperidol45 29 2 50 1115.4DTNBP1, HTR2A, DRD3
18amisulpride45 29 1113.3DRD3, HTR2A
19s330842911.3DRD3, HTR2A
20(+)-butaclamol29 4512.3HTR2A, DRD3
21antipsychotics5011.3MTHFR, COMT
22remoxipride45 1112.3DRD3, HTR2A
23duloxetine45 50 29 1114.2HTR2A, DRD3
24raclopride45 2912.2DRD3, HTR2A
25roxindole29 4512.2DRD3, HTR2A
26Chlorprothixene1111.2DRD3, HTR2A
27terguride29 4512.2DRD3, HTR2A
28spiperone29 4512.2DRD3, HTR2A
29dopac4511.2DRD3, COMT
30piperazine45 1112.1DRD3, HTR2A
31amantadine45 1112.1COMT, DRD3
32maoa4511.1HTR2A, COMT
33pimozide29 50 45 1114.1DRD3, HTR2A
34lisuride29 45 1113.1HTR2A, DRD3
35paliperidone45 1112.0DRD3, HTR2A
36Methotrimeprazine1111.0HTR2A, DRD3
37iloperidone50 45 29 1113.9HTR2A, DRD3
38asenapine29 1111.9DRD3, HTR2A
39quinpirole45 2911.8DRD3, HTR2A
40riboflavin45 11 2412.6DAO, MTHFR

GO Terms for genes affiliated with Schizophrenia

Sources:
16Gene Ontology
See all sources

Biological processes related to Schizophrenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405911.1DRD3, HTR2A, DTNBP1

Products for genes affiliated with Schizophrenia

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Sources for Schizophrenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet