MCID: SCH011
MIFTS: 33

Schizotypal Personality Disorder malady

Categories: Mental diseases

Aliases & Classifications for Schizotypal Personality Disorder

Aliases & Descriptions for Schizotypal Personality Disorder:

Name: Schizotypal Personality Disorder 12 52 42 14 69
Schizotypal Personality 52

Classifications:



External Ids:

Disease Ontology 12 DOID:10646
ICD10 33 F21
ICD9CM 35 301.22
MeSH 42 D012569
NCIt 47 C92632
SNOMED-CT 64 231486008 31027006
UMLS 69 C0036363

Summaries for Schizotypal Personality Disorder

Disease Ontology : 12 A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.

MalaCards based summary : Schizotypal Personality Disorder, also known as schizotypal personality, is related to personality disorder and schizophrenia. An important gene associated with Schizotypal Personality Disorder is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways is Androgen receptor signaling pathway. The drugs Guanfacine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and nervous system

Wikipedia : 71 Schizotypal personality disorder (STPD) or schizotypal disorder is a mental disorder characterized by... more...

Related Diseases for Schizotypal Personality Disorder

Diseases related to Schizotypal Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 personality disorder 31.3 COMT EP300
2 schizophrenia 30.2 CACNA1C COMT PSAT1 SULT4A1
3 obsessive-compulsive disorder 10.2
4 anorexia nervosa 10.0
5 borderline personality disorder 10.0
6 cerebritis 10.0
7 benign epilepsy with centrotemporal spikes 9.9 CACNA1C COMT
8 autism spectrum disorder 9.8 COMT EP300
9 avoidant personality disorder 9.8
10 childhood-onset schizophrenia 9.8
11 acute anterolateral myocardial infarction 9.1 CACNA1C COMT EP300 FLNA PSAT1 SULT4A1

Graphical network of the top 20 diseases related to Schizotypal Personality Disorder:



Diseases related to Schizotypal Personality Disorder

Symptoms & Phenotypes for Schizotypal Personality Disorder

GenomeRNAi Phenotypes related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.36 EP300
2 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 SULT4A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.36 EP300 SULT4A1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 EP300
5 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 SULT4A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.36 EP300
7 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.36 SULT4A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.36 EP300
9 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.36 EP300
10 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.36 EP300

MGI Mouse Phenotypes related to Schizotypal Personality Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 CACNA1C COMT EP300 FLNA PSAT1

Drugs & Therapeutics for Schizotypal Personality Disorder

Drugs for Schizotypal Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4,Phase 2 29110-47-2 3519
2 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
3 Adrenergic Agents Phase 4,Phase 2
4 Adrenergic Agonists Phase 4,Phase 2
5 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
6 Adrenergic alpha-Agonists Phase 4,Phase 2
7 Antihypertensive Agents Phase 4,Phase 2
8
Dopamine Approved Phase 2,Phase 1 51-61-6, 62-31-7 681
9
Risperidone Approved, Investigational Phase 1, Phase 2 106266-06-2 5073
10 Dihydrexidine Phase 2
11 Dopamine Agents Phase 2,Phase 1
12 Dopamine agonists Phase 2
13 Antipsychotic Agents Phase 1, Phase 2
14 Central Nervous System Depressants Phase 1, Phase 2
15 Dopamine Antagonists Phase 1, Phase 2
16 Psychotropic Drugs Phase 1, Phase 2
17
Serotonin Phase 1, Phase 2 50-67-9 5202
18 Serotonin Agents Phase 1, Phase 2
19 Serotonin Antagonists Phase 1, Phase 2
20 Tranquilizing Agents Phase 1, Phase 2
21 Autonomic Agents Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Protective Agents Phase 2
24
Oxytocin Approved, Vet_approved Phase 1 50-56-6 439302 53477758
25 Oxytocics Phase 1
26
Sertraline Approved 79617-96-2 68617
27
Aripiprazole Approved, Investigational 129722-12-9 60795
28 Antidepressive Agents
29 Neurotransmitter Uptake Inhibitors
30 Serotonin Uptake Inhibitors
31
Silicon 7440-21-3 4082203

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Pharmacology of Cognition in Schizotypal Personality Disorder Terminated NCT00353379 Phase 4
2 Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder Unknown status NCT01466205 Phase 2
3 Schizotypal Personality Disorder Risperidone Completed NCT02535156 Phase 1, Phase 2
4 CRT-Guanfacine for SPD Completed NCT02524899 Phase 2
5 A D1 Agonist For Working Memory Recruiting NCT02507206 Phase 2
6 Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations Recruiting NCT02149823 Phase 1
7 Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder Unknown status NCT00252044
8 Health Promotion on Young Adults With High Risk Disability for Mental Health Unknown status NCT01740167
9 Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder Completed NCT00158028
10 A Psychopathological Study of Latent (Early) Schizophrenia: Clinical Pathology/Neuropsychological Dysfunctions Completed NCT00155519
11 Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms Completed NCT00169988
12 Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis Completed NCT01619319
13 Extended Specialized Assertive Intervention for First Episode Psychosis Completed NCT00914238
14 Psychosis: Early Detection, Intervention and Prevention Completed NCT01597141
15 Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study Completed NCT01269710
16 Psychopathological Differences Between Asperger Syndrome and Schizotypal Disorder in an Adult Sample Recruiting NCT02800681
17 Personality Pathology and Cerebral Processing in Eating Disorders Recruiting NCT02980120
18 Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis Active, not recruiting NCT00157313
19 Aripiprazole Treatment of the Prodrome Terminated NCT00169949

Search NIH Clinical Center for Schizotypal Personality Disorder

Cochrane evidence based reviews: schizotypal personality disorder

Genetic Tests for Schizotypal Personality Disorder

Anatomical Context for Schizotypal Personality Disorder

MalaCards organs/tissues related to Schizotypal Personality Disorder:

39
Eye, Brain, Temporal Lobe, Caudate Nucleus, Testes, Breast, Pituitary

Publications for Schizotypal Personality Disorder

Articles related to Schizotypal Personality Disorder:

(show top 50) (show all 185)
id Title Authors Year
1
Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism. ( 27330977 )
2016
2
Characterization of the Fiber Connectivity Profile of the Cerebral Cortex in Schizotypal Personality Disorder: A Pilot Study. ( 27303358 )
2016
3
Biological Motion Perception, Brain Responses, and Schizotypal Personality Disorder. ( 26790398 )
2016
4
Decreased fractional anisotropy values in two clusters of white matter in patients with schizotypal personality disorder: A DTI study. ( 27178397 )
2016
5
Screening schizotypal personality disorder for detection of clinical high risk of psychosis in Chinese mental health services. ( 26165958 )
2015
6
The melbourne assessment of Schizotypy in kids: a useful measure of childhood schizotypal personality disorder. ( 25629050 )
2015
7
Sensory gating disturbances in the spectrum: similarities and differences in schizotypal personality disorder and schizophrenia. ( 25482574 )
2015
8
DSM-IV schizotypal personality disorder: a taxometric analysis among individuals with and without substance use disorders in the general population. ( 26322122 )
2014
9
Openness to experience, intellect, schizotypal personality disorder, and psychoticism: resolving the controversy. ( 24511900 )
2014
10
Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [(11)C]NNC112. ( 24781514 )
2014
11
Visual-spatial working memory performance and temporal gray matter volume predict schizotypal personality disorder group membership. ( 24398009 )
2014
12
Altered default mode network functional connectivity in schizotypal personality disorder. ( 25458858 )
2014
13
Effects of the D1 Dopamine Receptor Agonist Dihydrexidine (DAR-0100A) on Working Memory in Schizotypal Personality Disorder. ( 25074637 )
2014
14
White Matter Abnormalities in Schizophrenia and Schizotypal Personality Disorder. ( 24962608 )
2014
15
Schizotypal personality disorder: a current review. ( 24828284 )
2014
16
Working memory in schizotypal personality disorder: fMRI activation and deactivation differences. ( 24161536 )
2013
17
Semantic processing impairment in individuals with schizotypal personality disorder features: a preliminary event-related potential study. ( 22960083 )
2013
18
Does a latent class underlie schizotypal personality disorder? Implications for schizophrenia. ( 23713503 )
2013
19
Functional outcomes, functional capacity, and cognitive impairment in schizotypal personality disorder. ( 23375943 )
2013
20
Neuroimaging findings in schizotypal personality disorder: a systematic review. ( 23220094 )
2013
21
Larger putamen size in antipsychotic-naA^ve individuals with schizotypal personality disorder. ( 23187070 )
2013
22
Prodromal and autistic symptoms in schizotypal personality disorder and 22q11.2 deletion syndrome. ( 22686870 )
2013
23
Schizotypal personality disorder. ( 22928856 )
2013
24
CACNA1C as a risk factor for schizotypal personality disorder and schizotypy in healthy individuals. ( 22985546 )
2013
25
Association between cannabis use, psychosis, and schizotypal personality disorder: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. ( 24200416 )
2013
26
Empathic accuracy and cognition in schizotypal personality disorder. ( 23810511 )
2013
27
Globally and locally reduced MRI gray matter volumes in neuroleptic-naive men with schizotypal personality disorder: association with negative symptoms. ( 23389420 )
2013
28
Developmental trajectories of schizotypal personality disorder-like behavioural manifestations: a two-year longitudinal prospective study of college students. ( 24289659 )
2013
29
Some suggestions for the DSM-5 schizotypal personality disorder construct. ( 21741634 )
2012
30
Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy. ( 22995934 )
2012
31
A review of structural MRI and diffusion tensor imaging in schizotypal personality disorder. ( 22006127 )
2012
32
Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood. ( 22325079 )
2012
33
Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder. ( 22285558 )
2012
34
Prosodic abnormalities in schizotypal personality disorder. ( 23068317 )
2012
35
Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder. ( 21115066 )
2011
36
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression. ( 20955740 )
2011
37
Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder. ( 21223999 )
2011
38
Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder. ( 21507614 )
2011
39
The differential effects of child abuse and posttraumatic stress disorder on schizotypal personality disorder. ( 21683181 )
2011
40
Facial emotion recognition and facial affect display in schizotypal personality disorder. ( 21640557 )
2011
41
Evidence of reduced selective attention in schizotypal personality disorder. ( 21526445 )
2011
42
Deficient visual sensitivity in schizotypal personality disorder. ( 20541911 )
2011
43
Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder. ( 20817485 )
2010
44
Childhood adversity, mental disorder comorbidity, and suicidal behavior in schizotypal personality disorder. ( 21048469 )
2010
45
Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrum. ( 20130535 )
2010
46
Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment. ( 20362418 )
2010
47
Dichotic listening in schizotypal personality disorder: evidence for gender and laterality effects. ( 19464150 )
2009
48
Smaller superior temporal gyrus volume specificity in schizotypal personality disorder. ( 19473820 )
2009
49
Shape abnormalities of caudate nucleus in schizotypal personality disorder. ( 19328654 )
2009
50
Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder. ( 19327968 )
2009

Variations for Schizotypal Personality Disorder

Expression for Schizotypal Personality Disorder

Search GEO for disease gene expression data for Schizotypal Personality Disorder.

Pathways for Schizotypal Personality Disorder

Pathways related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.58 EP300 FLNA

GO Terms for Schizotypal Personality Disorder

Cellular components related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.1 CACNA1C COMT EP300 FLNA PSAT1 SULT4A1
2 Z disc GO:0030018 8.96 CACNA1C FLNA

Biological processes related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 8.62 EP300 FLNA

Molecular functions related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 8.92 COMT EP300 PSAT1 SULT4A1

Sources for Schizotypal Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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