MCID: SCH011
MIFTS: 38

Schizotypal Personality Disorder malady

Mental diseases category

Summaries for Schizotypal Personality Disorder

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.

MalaCards: Schizotypal Personality Disorder, also known as schizotypal personality, is related to schizophrenia and personality disorder. An important gene associated with Schizotypal Personality Disorder is COMT (catechol-O-methyltransferase), and among its related pathways is Metabolism. The compounds pyridoxal 5-phosphate and antipsychotics have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and temporal lobe, and related mouse phenotypes are reproductive system and nervous system.

Wikipedia:66 Schizotypal personality disorder is a personality disorder characterized by a need for social isolation,... more...

Aliases & Classifications for Schizotypal Personality Disorder

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

schizotypal personality disorder 9 11 46 63
schizotypal personality 46


External Ids:

Disease Ontology9 DOID:10646
MeSH36 D012569
SNOMED-CT59 231486008, 31027006
ICD9CM28 301.22

Related Diseases for Schizotypal Personality Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Schizotypal Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.2LBR, ZNF804A, COMT, CACNA1C
2personality disorder11.3
3obsessive-compulsive disorder10.6
4borderline personality disorder10.4
5anorexia nervosa10.4
6major depressive disorder10.2
7avoidant personality disorder10.2
8schizoaffective disorder10.2
9cerebritis10.2
10childhood-onset schizophrenia10.2
11gilles de la tourette syndrome10.2
12skeletal dysplasias10.0FLNA, LBR

Graphical network of diseases related to Schizotypal Personality Disorder:



Diseases related to schizotypal personality disorder

Symptoms for Schizotypal Personality Disorder

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Drugs & Therapeutics for Schizotypal Personality Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Schizotypal Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Schizotypal Personality Disorder

Search NIH Clinical Center for Schizotypal Personality Disorder

Search CenterWatch for Schizotypal Personality Disorder

Genetic Tests for Schizotypal Personality Disorder

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Anatomical Context for Schizotypal Personality Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Schizotypal Personality Disorder:

34
Eye, Brain, Temporal lobe, Caudate nucleus, Testes, Breast, Pituitary

Animal Models for Schizotypal Personality Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Schizotypal Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.1LBR, FLNA, COMT, CACNA1C, ARHGAP32
2MP:00036317.5LBR, FLNA, PSAT1, COMT, CACNA1C, ARHGAP32

Publications for Schizotypal Personality Disorder

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Sources:
53PubMed
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Articles related to Schizotypal Personality Disorder:

(show top 50)    (show all 167)
idTitleAuthorsYear
1
Schizotypal personality disorder. (22928856)
2013
2
Neuroimaging findings in schizotypal personality disorder: a systematic review. (23220094)
2013
3
Semantic processing impairment in individuals with schizotypal personality disorder features: a preliminary event-related potential study. (22960083)
2013
4
Empathic accuracy and cognition in schizotypal personality disorder. (23810511)
2013
5
A review of structural MRI and diffusion tensor imaging in schizotypal personality disorder. (22006127)
2012
6
Some suggestions for the DSM-5 schizotypal personality disorder construct. (21741634)
2012
7
Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood. (22325079)
2012
8
Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder. (21115066)
2011
9
The differential effects of child abuse and posttraumatic stress disorder on schizotypal personality disorder. (21683181)
2011
10
Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder. (19327968)
2009
11
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
12
The heterogeneous structure of schizotypal personality disorder: item-level factors of the Schizotypal Personality Questionnaire and their associations with obsessive-compulsive disorder symptoms, dissociative tendencies, and normal personality. (18489212)
2008
13
Psychological trauma and schizotypal personality disorder. (18729605)
2008
14
Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder. (17015811)
2006
15
Dual-task information processing in schizotypal personality disorder: evidence of impaired processing capacity. (16846263)
2006
16
Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor. (16806835)
2006
17
Cognitive function and symptoms in adolescents with schizotypal personality disorder. (16611879)
2006
18
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. (16691129)
2006
19
Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder. (15985362)
2005
20
Striatal Amphetamine-induced Dopamine Release in Schizotypal Personality Disorder. (15717985)
2005
21
A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder. (15694753)
2005
22
Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family. (16094256)
2005
23
The five-factor model in schizotypal personality disorder. (16168625)
2005
24
Processing sentence context in women with schizotypal personality disorder: an ERP study. (15102121)
2004
25
A MRI study of fusiform gyrus in schizotypal personality disorder. (14511799)
2003
26
Neuromotor functioning in adolescents with schizotypal personality disorder: associations with symptoms and neurocognition. (14552504)
2003
27
MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder. (12091198)
2002
28
Cognitive and brain function in schizotypal personality disorder. (11853990)
2002
29
Executive functions in adolescents with schizotypal personality disorder. (10742650)
2000
30
Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. (10618013)
2000
31
Lateralized P3 deficit in schizotypal personality disorder. (11032982)
2000
32
Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. (10785578)
2000
33
Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. (11007721)
2000
34
Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. (10356620)
1999
35
Cognitive functions in schizotypal personality disorder. (10374648)
1999
36
Electrophysiological correlates of language processing in schizotypal personality disorder. (10401451)
1999
37
Abnormal orienting in schizotypal personality disorder. (9050114)
1997
38
Regional cerebral blood flow during the Wisconsin Card Sort Test in schizotypal personality disorder. (9373891)
1997
39
Social skills training in a case of obsessive-compulsive disorder with schizotypal personality disorder. (8894918)
1996
40
Event-related potentials in schizotypal personality disorder. (8845699)
1996
41
Lateral ventricular enlargement in schizotypal personality disorder. (7480378)
1995
42
"True" schizotypal personality disorder: a study of co-twins and relatives of schizophrenic probands. (8214174)
1993
43
Schizotypal personality disorder in individuals with and without schizophrenic relatives: similarities and contrasts in neurocognitive and clinical functioning. (1591195)
1992
44
Self-amputation of the breasts by a male with schizotypal personality disorder. (1572617)
1992
45
Cognitive and perceptual distortions in borderline personality disorder and schizotypal personality disorder in a vignette sample. (1591910)
1992
46
Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. (2289947)
1990
47
Eye tracking impairment in clinically identified patients with schizotypal personality disorder. (2343917)
1990
48
Eye tracking, schizophrenic symptoms, and schizotypal personality disorder. (2792157)
1989
49
A psychometric analysis of the social-interpersonal and cognitive-perceptual items for the schizotypal personality disorder. (3632246)
1987
50
Schizotypal personality disorder: an operational definition of Bleuler's latent schizophrenia? (4081652)
1985

Variations for Schizotypal Personality Disorder

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Expression for genes affiliated with Schizotypal Personality Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Schizotypal Personality Disorder

Search GEO for disease gene expression data for Schizotypal Personality Disorder.

Pathways for genes affiliated with Schizotypal Personality Disorder

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Sources:
51PathCards, 56Reactome, 31KEGG
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Pathways related to Schizotypal Personality Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.4CACNA1C, COMT, PSAT1, SULT4A1, LBR

Compounds for genes affiliated with Schizotypal Personality Disorder

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Schizotypal Personality Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate469.8COMT, PSAT1
2antipsychotics529.5COMT, ZNF804A
3calcium46 52 25 1210.8ARHGAP32, CACNA1C, PSAT1, FLNA, LBR

GO Terms for genes affiliated with Schizotypal Personality Disorder

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Sources:
17Gene Ontology
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Cellular components related to Schizotypal Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic densityGO:0140699.3ARHGAP32, CACNA1C
2dendritic shaftGO:0431989.3CACNA1C, FLNA
3cytosolGO:0058298.2ARHGAP32, COMT, PSAT1, FLNA, SULT4A1

Biological processes related to Schizotypal Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.4CACNA1C, COMT, PSAT1, SULT4A1, LBR

Products for genes affiliated with Schizotypal Personality Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Schizotypal Personality Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet