MCID: SCH011
MIFTS: 36

Schizotypal Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Schizotypal Personality Disorder

MalaCards integrated aliases for Schizotypal Personality Disorder:

Name: Schizotypal Personality Disorder 12 72 51 41 14 69
Schizotypal Personality 51

Classifications:



External Ids:

Disease Ontology 12 DOID:10646
ICD10 32 F21
ICD9CM 34 301.22
MeSH 41 D012569
NCIt 46 C92632
SNOMED-CT 64 231486008 31027006
UMLS 69 C0036363

Summaries for Schizotypal Personality Disorder

Disease Ontology : 12 A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs.

MalaCards based summary : Schizotypal Personality Disorder, also known as schizotypal personality, is related to schizophrenia and schizoaffective disorder. An important gene associated with Schizotypal Personality Disorder is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways is Androgen receptor signaling pathway. The drugs Guanfacine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Schizotypal personality disorder (STPD) or schizotypal disorder is a mental disorder characterized by... more...

Related Diseases for Schizotypal Personality Disorder

Diseases related to Schizotypal Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 29.7 CACNA1C COMT PSAT1 SULT4A1
2 schizoaffective disorder 29.6 COMT SULT4A1
3 disease of mental health 29.2 COMT EP300
4 personality disorder 11.0
5 obsessive-compulsive disorder 10.3
6 borderline personality disorder 10.1
7 blood group, i system 10.1
8 bulimia nervosa 2 10.1
9 cerebritis 10.1
10 autism 9.9
11 major depressive disorder 9.9
12 avoidant personality disorder 9.9
13 childhood-onset schizophrenia 9.9
14 ring chromosome y syndrome 9.9
15 mood disorder 9.7 CACNA1C COMT

Graphical network of the top 20 diseases related to Schizotypal Personality Disorder:



Diseases related to Schizotypal Personality Disorder

Symptoms & Phenotypes for Schizotypal Personality Disorder

GenomeRNAi Phenotypes related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.36 EP300
2 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 SULT4A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.36 EP300 SULT4A1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.36 EP300
5 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 SULT4A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.36 EP300
7 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.36 SULT4A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.36 EP300
9 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.36 EP300
10 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.36 EP300

MGI Mouse Phenotypes related to Schizotypal Personality Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 CACNA1C COMT EP300 FLNA PSAT1

Drugs & Therapeutics for Schizotypal Personality Disorder

Drugs for Schizotypal Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4,Phase 2 29110-47-2 3519
2 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Early Phase 1
3 Adrenergic Agents Phase 4,Phase 2
4 Adrenergic Agonists Phase 4,Phase 2
5 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
6 Adrenergic alpha-Agonists Phase 4,Phase 2
7 Antihypertensive Agents Phase 4,Phase 2
8
Dopamine Approved Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
9
Risperidone Approved, Investigational Phase 1, Phase 2 106266-06-2 5073
10 Dihydrexidine Investigational Phase 2 123039-93-0
11 Dopamine Agents Phase 2,Phase 1,Early Phase 1
12 Dopamine agonists Phase 2,Early Phase 1
13 Antipsychotic Agents Phase 1, Phase 2
14 Central Nervous System Depressants Phase 1, Phase 2
15 Dopamine Antagonists Phase 1, Phase 2
16 Psychotropic Drugs Phase 1, Phase 2
17
Serotonin Phase 1, Phase 2 50-67-9 5202
18 Serotonin Agents Phase 1, Phase 2
19 Serotonin Antagonists Phase 1, Phase 2
20 Tranquilizing Agents Phase 1, Phase 2
21 Autonomic Agents Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Protective Agents Phase 2
24
Oxytocin Approved, Vet_approved Phase 1 50-56-6 53477758 439302
25 Oxytocics Phase 1
26 Benserazide Approved, Investigational Early Phase 1 322-35-0
27
Levodopa Approved Early Phase 1 59-92-7 6047
28
Sertraline Approved 79617-96-2 68617
29
Adenosine Approved, Investigational 58-61-7 60961
30
Aripiprazole Approved, Investigational 129722-12-9 60795
31 Antiparkinson Agents Early Phase 1
32 Benserazide, levodopa drug combination Early Phase 1
33 Dihydroxyphenylalanine Early Phase 1
34 Antidepressive Agents
35 Neurotransmitter Uptake Inhibitors
36 Serotonin Uptake Inhibitors

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Pharmacology of Cognition in Schizotypal Personality Disorder Terminated NCT00353379 Phase 4 Guanfacine;Placebo
2 Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder Unknown status NCT01466205 Phase 2 DAR-0100A;Placebo
3 Schizotypal Personality Disorder Risperidone Completed NCT02535156 Phase 1, Phase 2 Risperidone;Placebo
4 CRT-Guanfacine for SPD Completed NCT02524899 Phase 2 Guanfacine;Placebo
5 A D1 Agonist For Working Memory Recruiting NCT02507206 Phase 2 DAR 0-100A;Placebo
6 Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations Recruiting NCT02149823 Phase 1 Syntocinon 24 Intranasal Units (IU);Syntocinon 40 Intranasal Units (IU);Intranasal Placebo
7 Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder Unknown status NCT00252044 Pergolide
8 Health Promotion on Young Adults With High Risk Disability for Mental Health Unknown status NCT01740167
9 Risperidone in the Treatment of Psychotic-like and Deficit Symptoms of Schizotypal Personality Disorder Completed NCT00158028 Risperidone;Placebo
10 Exceptional Experiences (EE), Salience & Dopaminergic Neurotransmission Completed NCT03333369 Early Phase 1 200 mg levodopa/50 mg benserazide;Dextrose
11 A Psychopathological Study of Latent (Early) Schizophrenia: Clinical Pathology/Neuropsychological Dysfunctions Completed NCT00155519
12 Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis Completed NCT01619319
13 Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms Completed NCT00169988 risperidone;sertraline-primary
14 Extended Specialized Assertive Intervention for First Episode Psychosis Completed NCT00914238
15 Psychosis: Early Detection, Intervention and Prevention Completed NCT01597141
16 Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study Completed NCT01269710
17 Psychopathological Differences Between Asperger Syndrome and Schizotypal Disorder in an Adult Sample Recruiting NCT02800681
18 Neurofeedback Training for High Risk Psychosis Recruiting NCT03447548
19 Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis Active, not recruiting NCT00157313
20 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology Not yet recruiting NCT03355781
21 Aripiprazole Treatment of the Prodrome Terminated NCT00169949 aripiprazole

Search NIH Clinical Center for Schizotypal Personality Disorder

Cochrane evidence based reviews: schizotypal personality disorder

Genetic Tests for Schizotypal Personality Disorder

Anatomical Context for Schizotypal Personality Disorder

MalaCards organs/tissues related to Schizotypal Personality Disorder:

38
Testes, Brain, Eye, Caudate Nucleus, Temporal Lobe, Pituitary, Cortex

Publications for Schizotypal Personality Disorder

Articles related to Schizotypal Personality Disorder:

(show top 50) (show all 191)
# Title Authors Year
1
Enhanced mental imagery and intact perceptual organization in schizotypal personality disorder. ( 29131991 )
2018
2
Antipsychotic treatment of schizotypy and schizotypal personality disorder: a systematic review. ( 28347257 )
2017
3
Dissociation of Brain Activation in Autism and Schizotypal Personality Disorder During Social Judgments. ( 29088456 )
2017
4
Comparing Facial Emotional Recognition in Patients with Borderline Personality Disorder and Patients with Schizotypal Personality Disorder with a Normal Group. ( 28659980 )
2017
5
Supervoxel-based statistical analysis of diffusion tensor imaging in schizotypal personality disorder. ( 28712990 )
2017
6
Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder. ( 28152990 )
2017
7
Characterization of the Fiber Connectivity Profile of the Cerebral Cortex in Schizotypal Personality Disorder: A Pilot Study. ( 27303358 )
2016
8
Decreased fractional anisotropy values in two clusters of white matter in patients with schizotypal personality disorder: A DTI study. ( 27178397 )
2016
9
Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism. ( 27330977 )
2016
10
Biological Motion Perception, Brain Responses, and Schizotypal Personality Disorder. ( 26790398 )
2016
11
The melbourne assessment of Schizotypy in kids: a useful measure of childhood schizotypal personality disorder. ( 25629050 )
2015
12
Sensory gating disturbances in the spectrum: similarities and differences in schizotypal personality disorder and schizophrenia. ( 25482574 )
2015
13
Screening schizotypal personality disorder for detection of clinical high risk of psychosis in Chinese mental health services. ( 26165958 )
2015
14
White Matter Abnormalities in Schizophrenia and Schizotypal Personality Disorder. ( 24962608 )
2014
15
Prefrontal dopamine D1 receptors and working memory in schizotypal personality disorder: a PET study with [(11)C]NNC112. ( 24781514 )
2014
16
Visual-spatial working memory performance and temporal gray matter volume predict schizotypal personality disorder group membership. ( 24398009 )
2014
17
DSM-IV schizotypal personality disorder: a taxometric analysis among individuals with and without substance use disorders in the general population. ( 26322122 )
2014
18
Schizotypal personality disorder: a current review. ( 24828284 )
2014
19
Altered default mode network functional connectivity in schizotypal personality disorder. ( 25458858 )
2014
20
Openness to experience, intellect, schizotypal personality disorder, and psychoticism: resolving the controversy. ( 24511900 )
2014
21
Effects of the D1 Dopamine Receptor Agonist Dihydrexidine (DAR-0100A) on Working Memory in Schizotypal Personality Disorder. ( 25074637 )
2014
22
Developmental trajectories of schizotypal personality disorder-like behavioural manifestations: a two-year longitudinal prospective study of college students. ( 24289659 )
2013
23
Schizotypal personality disorder. ( 22928856 )
2013
24
Globally and locally reduced MRI gray matter volumes in neuroleptic-naive men with schizotypal personality disorder: association with negative symptoms. ( 23389420 )
2013
25
Working memory in schizotypal personality disorder: fMRI activation and deactivation differences. ( 24161536 )
2013
26
Prodromal and autistic symptoms in schizotypal personality disorder and 22q11.2 deletion syndrome. ( 22686870 )
2013
27
Does a latent class underlie schizotypal personality disorder? Implications for schizophrenia. ( 23713503 )
2013
28
Association between cannabis use, psychosis, and schizotypal personality disorder: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. ( 24200416 )
2013
29
Neuroimaging findings in schizotypal personality disorder: a systematic review. ( 23220094 )
2013
30
Larger putamen size in antipsychotic-naA^ve individuals with schizotypal personality disorder. ( 23187070 )
2013
31
Empathic accuracy and cognition in schizotypal personality disorder. ( 23810511 )
2013
32
CACNA1C as a risk factor for schizotypal personality disorder and schizotypy in healthy individuals. ( 22985546 )
2013
33
Functional outcomes, functional capacity, and cognitive impairment in schizotypal personality disorder. ( 23375943 )
2013
34
Semantic processing impairment in individuals with schizotypal personality disorder features: a preliminary event-related potential study. ( 22960083 )
2013
35
Prosodic abnormalities in schizotypal personality disorder. ( 23068317 )
2012
36
Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder. ( 22285558 )
2012
37
A review of structural MRI and diffusion tensor imaging in schizotypal personality disorder. ( 22006127 )
2012
38
Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood. ( 22325079 )
2012
39
Some suggestions for the DSM-5 schizotypal personality disorder construct. ( 21741634 )
2012
40
Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy. ( 22995934 )
2012
41
Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder. ( 21223999 )
2011
42
Facial emotion recognition and facial affect display in schizotypal personality disorder. ( 21640557 )
2011
43
Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder. ( 21115066 )
2011
44
Evidence of reduced selective attention in schizotypal personality disorder. ( 21526445 )
2011
45
Deficient visual sensitivity in schizotypal personality disorder. ( 20541911 )
2011
46
A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression. ( 20955740 )
2011
47
The differential effects of child abuse and posttraumatic stress disorder on schizotypal personality disorder. ( 21683181 )
2011
48
Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder. ( 21507614 )
2011
49
Childhood adversity, mental disorder comorbidity, and suicidal behavior in schizotypal personality disorder. ( 21048469 )
2010
50
Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment. ( 20362418 )
2010

Variations for Schizotypal Personality Disorder

Expression for Schizotypal Personality Disorder

Search GEO for disease gene expression data for Schizotypal Personality Disorder.

Pathways for Schizotypal Personality Disorder

Pathways related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 EP300 FLNA

GO Terms for Schizotypal Personality Disorder

Cellular components related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.1 CACNA1C COMT EP300 FLNA PSAT1 SULT4A1
2 Z disc GO:0030018 8.96 CACNA1C FLNA

Biological processes related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 8.96 EP300 FLNA
2 response to estrogen GO:0043627 8.62 COMT EP300

Molecular functions related to Schizotypal Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 8.92 COMT EP300 PSAT1 SULT4A1

Sources for Schizotypal Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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