MCID: SCH010
MIFTS: 24

Schneiderian Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Schneiderian Carcinoma

MalaCards integrated aliases for Schneiderian Carcinoma:

Name: Schneiderian Carcinoma 12 14 69
Cylindrical Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4003
NCIt 47 C54287
SNOMED-CT 64 5600009
UMLS 69 C0334270

Summaries for Schneiderian Carcinoma

MalaCards based summary : Schneiderian Carcinoma, also known as cylindrical cell carcinoma, is related to laryngeal mucoepidermoid carcinoma and mucoepidermoid thyroid carcinoma, and has symptoms including pain and rhinorrhea. An important gene associated with Schneiderian Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. Affiliated tissues include tonsil and liver, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Schneiderian Carcinoma

Diseases related to Schneiderian Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
id Related Disease Score Top Affiliating Genes
1 laryngeal mucoepidermoid carcinoma 10.2 CRTC1 MAML2
2 mucoepidermoid thyroid carcinoma 10.2 CRTC1 MAML2
3 eccrine papillary adenoma 10.2 CRTC1 MAML2
4 pancreatic serous cystadenoma 10.2 CRTC1 MAML2
5 connective tissue benign neoplasm 10.0 KRT5 MAML2
6 olivopontocerebellar atrophy deafness 10.0 KRT18 KRT5
7 urethra clear cell adenocarcinoma 10.0 KRT18 KRT5
8 cribriform carcinoma 10.0 KRT18 KRT5
9 pulmonary subvalvular stenosis 9.9 CRTC1 MAML2
10 epicardium cancer 9.9 KRT18 KRT5
11 hypochromic microcytic anemia 9.9 KRT18 KRT5
12 sebaceous adenocarcinoma 9.8 KRT18 KRT5
13 measles 9.8 CRTC1 MAML2
14 sinusitis 9.7
15 endodermal sinus tumor 9.7
16 lipid-cell variant infiltrating bladder urothelial carcinoma 9.7 KRT5 SMUG1
17 aspergillosis 9.7
18 liver disease 9.7
19 polycystic liver disease 9.7
20 tonsillitis 9.7
21 papilloma 9.7
22 inverted papilloma 9.7
23 pancreatitis 9.7
24 sinonasal undifferentiated carcinoma 9.7
25 webster deming syndrome 9.7 CRTC1 KRT18 MAML2
26 familial periodic paralysis 9.7 KRT5 SMUG1
27 arteriolosclerosis 9.6 KRT5 SMUG1
28 familial lipoprotein lipase deficiency 9.6 KRT5 SMUG1
29 vaginal adenoma 9.6 CRTC1 KRT5 MAML2
30 plasmodium ovale malaria 9.6 CRTC1 KRT5 MAML2
31 nominal aphasia 9.6 CRTC1 MAML2
32 mixed type thymoma 9.4 KRT5 SMUG1
33 brown-vialetto-van laere syndrome 9.4 KRT5 SMUG1
34 rete testis neoplasm 9.4 CRTC1 MAML2 SMUG1
35 fallopian tube transitional cell carcinoma 8.3 CRTC1 KRT18 KRT5 MAML2 SMUG1

Graphical network of the top 20 diseases related to Schneiderian Carcinoma:



Diseases related to Schneiderian Carcinoma

Symptoms & Phenotypes for Schneiderian Carcinoma

UMLS symptoms related to Schneiderian Carcinoma:


pain, rhinorrhea

GenomeRNAi Phenotypes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.66 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.66 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.66 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.66 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.66 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.66 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.66 KRT18 KRT5
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.66 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.66 KRT5

Drugs & Therapeutics for Schneiderian Carcinoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Schneiderian Carcinoma

Genetic Tests for Schneiderian Carcinoma

Anatomical Context for Schneiderian Carcinoma

MalaCards organs/tissues related to Schneiderian Carcinoma:

39
Tonsil, Liver

Publications for Schneiderian Carcinoma

Articles related to Schneiderian Carcinoma:

id Title Authors Year
1
Low-Grade Papillary Schneiderian Carcinoma: A Case Report. ( 28639124 )
2017
2
Hepatobiliary and Pancreatic: A unique case of HPV related metastatic Schneiderian carcinoma presenting as polycystic liver disease. ( 28052462 )
2017
3
Low-grade Papillary Schneiderian Carcinoma, a Unique and Deceptively Bland Malignant Neoplasm: Report of a Case. ( 25634744 )
2015
4
Exophytic schneiderian carcinoma of the lacrimal sac: first case report. ( 24977732 )
2014
5
Schneiderian carcinoma developing in an inverted papilloma of the palatine tonsil: an unusual case. ( 21563078 )
2011
6
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009

Variations for Schneiderian Carcinoma

Expression for Schneiderian Carcinoma

Search GEO for disease gene expression data for Schneiderian Carcinoma.

Pathways for Schneiderian Carcinoma

Pathways related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 KRT18 KRT5

GO Terms for Schneiderian Carcinoma

Cellular components related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.96 KRT18 KRT5
2 keratin filament GO:0045095 8.62 KRT18 KRT5

Biological processes related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT18 KRT5
2 cornification GO:0070268 8.62 KRT18 KRT5

Molecular functions related to Schneiderian Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT18 KRT5

Sources for Schneiderian Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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