Aliases & Classifications for Scleral Disease

MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 14
Scleral Diseases 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11343
ICD10 32 H15 H15.9
MeSH 41 D015422
NCIt 46 C79717
SNOMED-CT 64 33064008
UMLS 69 C0036412

Summaries for Scleral Disease

MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to arthritis and chorioretinitis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Scleral Disease

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 arthritis 29.1 IL1RN TNF TNFRSF1B
2 chorioretinitis 10.4 MRAP SRCIN1
3 iritis 10.3 MRAP TNFRSF1B
4 tenosynovitis 10.3 MRAP TNFRSF1B
5 orbital plasma cell granuloma 10.3 MRAP TNFRSF1B
6 chronic orbital inflammation 10.3 MRAP TNFRSF1B
7 posterior scleritis 10.3 MRAP TNF
8 coccidiosis 10.2 MRAP TNF
9 skin sarcoidosis 10.2 TNF TNFRSF1B
10 rheumatoid lung disease 10.2 TNF TNFRSF1B
11 chronic gonococcal salpingitis 10.2 TNF TNFRSF1B
12 granulomatous dermatitis 10.2 TNF TNFRSF1B
13 chondromalacia 10.2 IL1RN TNFRSF1B
14 peroneal neuropathy 10.2 TNF TNFRSF1B
15 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
16 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
17 chronic salpingitis 10.2 TNF TNFRSF1B
18 parasitic helminthiasis infectious disease 10.2 SRCIN1 TNF
19 cogan syndrome 10.1 TNF TNFRSF1B
20 vulvar vestibulitis syndrome 10.1 IL1RN TNF
21 spondyloarthropathy 10.1 MRAP TNF
22 cerebral artery occlusion 10.1 IL1RN TNF
23 osteosclerotic myeloma 10.1 IL1RN TNF
24 guillain-barre syndrome 10.1 TNF TNFRSF1B
25 aseptic meningitis 10.1 IL1RN TNF
26 joint disorders 10.1 IL1RN TNF
27 adult-onset still's disease 10.1 IL1RN TNF
28 aphthous stomatitis 10.1 IL1RN TNF
29 dengue shock syndrome 10.1 IL1RN TNF
30 idiopathic neutropenia 10.0 IL1RN TNF
31 brucellosis 10.0 IL1RN TNF
32 peptic ulcer disease 10.0 IL1RN TNF
33 aggressive periodontitis 10.0 IL1RN TNF
34 silicosis 10.0 IL1RN TNF
35 pustulosis of palm and sole 10.0 MRAP TNF TNFRSF1B
36 acute salpingitis 10.0 MRAP TNF TNFRSF1B
37 atrophic gastritis 10.0 IL1RN TNF
38 panuveitis 10.0 MRAP TNF TNFRSF1B
39 palindromic rheumatism 10.0 MRAP TNF TNFRSF1B
40 intestinal disease 10.0 MRAP TNF TNFRSF1B
41 duodenal ulcer 10.0 IL1RN TNF
42 familial mediterranean fever 9.9 IL1RN TNF
43 autoinflammation, lipodystrophy, and dermatosis syndrome 9.9 IL1RN TNF
44 spondylitis 9.9 TNF TNFRSF1B
45 osteomyelitis 9.9 IL1RN TNF
46 helicobacter pylori infection 9.9 IL1RN TNF
47 sweat gland disease 9.8 IL1RN TNF TNFRSF1B
48 exanthem 9.8 IL1RN TNF TNFRSF1B
49 juvenile rheumatoid arthritis 9.8 IL1RN TNF TNFRSF1B
50 autoimmune disease 9.8 IL1RN TNF TNFRSF1B

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease

Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:


eye manifestations

Drugs & Therapeutics for Scleral Disease

Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 4
2 beta-endorphin Phase 4
3 Hormone Antagonists Phase 4,Phase 2,Phase 1
4 Hormones Phase 4,Phase 2,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4
7
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
8
Infliximab Approved Phase 2,Phase 1 170277-31-3
9
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
10
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
11
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
12
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
13
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
14
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Antibiotics, Antitubercular Phase 1, Phase 2
17 Anti-Infective Agents Phase 1, Phase 2
18 Immunosuppressive Agents Phase 1, Phase 2
19 Antirheumatic Agents Phase 1, Phase 2
20 Antifungal Agents Phase 1, Phase 2
21 Anti-Inflammatory Agents Phase 2,Phase 1
22 Antineoplastic Agents, Hormonal Phase 2,Phase 1
23 Dermatologic Agents Phase 2,Phase 1
24 Gastrointestinal Agents Phase 2,Phase 1
25 glucocorticoids Phase 2,Phase 1
26 Alkylating Agents Phase 2
27
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
28 Antiemetics Phase 1
29 Autonomic Agents Phase 1
30 BB 1101 Phase 1
31 Dexamethasone 21-phosphate Phase 1
32 Dexamethasone acetate Phase 1 1177-87-3
33 HIV Protease Inhibitors Phase 1
34 Ophthalmic Solutions Phase 1
35 Peripheral Nervous System Agents Phase 1
36 Pharmaceutical Solutions Phase 1
37
protease inhibitors Phase 1
38
Adalimumab Approved 331731-18-1 16219006
39
Azathioprine Approved 446-86-6 2265
40
Etanercept Approved, Investigational 185243-69-0
41
Methylprednisolone Approved, Vet_approved 83-43-2 6741
42
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
43
Mycophenolic acid Approved 24280-93-1 446541
44
Prednisolone Approved, Vet_approved 50-24-8 5755
45 Antimetabolites
46 Antimetabolites, Antineoplastic
47 Antitubercular Agents
48 Cyclosporins
49 Methylprednisolone acetate
50 Methylprednisolone Hemisuccinate

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
3 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
4 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
5 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
6 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Not yet recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
7 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
8 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
9 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
10 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
11 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823
12 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567
13 Human Samples and Data Repository Completed NCT00539370

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

Genetic Tests for Scleral Disease

Anatomical Context for Scleral Disease

MalaCards organs/tissues related to Scleral Disease:

38
Eye

Publications for Scleral Disease

Articles related to Scleral Disease:

# Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951

Variations for Scleral Disease

Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

Pathways for Scleral Disease

GO Terms for Scleral Disease

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.5 IL1RN TNF TNFRSF1B
2 apoptotic signaling pathway GO:0097190 9.37 TNF TNFRSF1B
3 response to glucocorticoid GO:0051384 9.26 IL1RN TNF
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
5 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Sources for Scleral Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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