Aliases & Classifications for Scleral Disease

Aliases & Descriptions for Scleral Disease:

Name: Scleral Disease 12 14
Scleral Diseases 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11343
ICD10 33 H15 H15.9
MeSH 42 D015422
NCIt 47 C79717
SNOMED-CT 64 33064008
UMLS 69 C0036412

Summaries for Scleral Disease

MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to croup and plasmodium falciparum malaria, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Lidocaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is craniofacial.

Related Diseases for Scleral Disease

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
id Related Disease Score Top Affiliating Genes
1 croup 10.2 MRAP TNFRSF1B
2 plasmodium falciparum malaria 10.2 MRAP TNFRSF1B
3 primary thrombocytopenia 10.2 MRAP SRCIN1
4 primary lacrimal atrophy 10.1 MRAP TNFRSF1B
5 prostate calculus 10.1 MRAP TNF
6 cardiac sarcoidosis 10.1 TNF TNFRSF1B
7 childhood infratentorial neoplasm 10.1 TNF TNFRSF1B
8 nemaline myopathy 1, autosomal dominant or recessive 10.1 TNF TNFRSF1B
9 urethral intrinsic sphincter deficiency 10.1 MRAP TNF
10 multiple epiphyseal dysplasia 10.1 TNF TNFRSF1B
11 dermatitis herpetiformis 10.1 TNF TNFRSF1B
12 tularemia 10.1 MRAP TNF
13 inclusion conjunctivitis 10.1 MRAP SRCIN1 TNFRSF1B
14 primary ciliary dyskinesia 10.0 TNF TNFRSF1B
15 occupational dermatitis 10.0 MRAP TNF TNFRSF1B
16 nephronophthisis 1, juvenile 10.0 MRAP TNF TNFRSF1B
17 cryptococcosis 10.0 MRAP TNF TNFRSF1B
18 conjunctival vascular disease 10.0 MRAP TNF TNFRSF1B
19 patau syndrome 10.0 MRAP TNF TNFRSF1B
20 newcastle disease 10.0 MRAP TNF TNFRSF1B
21 celiac disease 10.0 MRAP TNF TNFRSF1B
22 uterine ligament clear cell adenocarcinoma 10.0 MRAP TNF TNFRSF1B
23 bone angioendothelial sarcoma 10.0 MRAP TNF TNFRSF1B
24 acinic cell breast carcinoma 10.0 TNF TNFRSF1B
25 choreatic disease 10.0 TNF TNFRSF1B
26 intracranial hemorrhage in brain cerebrovascular malformations 10.0 MRAP TNF TNFRSF1B
27 skin granular cell tumor 10.0 MRAP PAX6
28 lymph node adenoid cystic carcinoma 10.0 TNF TNFRSF1B
29 goodpasture syndrome 9.9 MRAP TNF TNFRSF1B
30 choanal atresia, bilateral 9.9 PAX6 TNF
31 pseudopterygium 9.7 CRYBB1 PAX6
32 rheumatoid arthritis 9.5
33 arthritis 9.5
34 rheumatic disease 9.5
35 bladder calculus 8.9 CRYBB1 MAPKAP1 MRAP PAX6 SRCIN1 TNF

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease

Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:


eye manifestations

MGI Mouse Phenotypes related to Scleral Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 8.92 TNFRSF1B UROS PAX6 TNF

Drugs & Therapeutics for Scleral Disease

Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
3
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741 24759
4
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
5
Ritonavir Approved, Investigational Phase 4,Phase 2 155213-67-5 392622
6
Zinc Approved Phase 4 7440-66-6 32051 23994
7 Zinc sulfate Approved Phase 4 7733-02-0
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
9 Anesthetics Phase 4
10 Anesthetics, Local Phase 4
11 Anti-Arrhythmia Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 1
15 Sodium Channel Blockers Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antirheumatic Agents Phase 4,Phase 1,Phase 2
18 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
19 triamcinolone acetonide Phase 4,Phase 3
20 Triamcinolone diacetate Phase 4,Phase 3
21 Triamcinolone hexacetonide Phase 4,Phase 3
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
24 Mitomycins Phase 4,Phase 3,Phase 2
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
26 Alkylating Agents Phase 4,Phase 3,Phase 2
27 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
28 Ophthalmic Solutions Phase 4,Phase 3,Phase 1
29 Tetrahydrozoline Phase 4,Phase 3
30 Adrenocorticotropic Hormone Phase 4
31 beta-endorphin Phase 4
32 Hormone Antagonists Phase 4,Phase 2,Phase 1
33 Hormones Phase 4,Phase 2,Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
35 Melanocyte-Stimulating Hormones Phase 4
36 Analgesics Phase 4
37 Analgesics, Non-Narcotic Phase 4
38 Anti-Inflammatory Agents, Non-Steroidal Phase 4
39 Cyclooxygenase Inhibitors Phase 4
40 Ketorolac Tromethamine Phase 4
41 Anti-HIV Agents Phase 4,Phase 2
42 Anti-Infective Agents Phase 4,Phase 1,Phase 2
43 Anti-Retroviral Agents Phase 4,Phase 2
44 Antiviral Agents Phase 4,Phase 2
45 Astringents Phase 4
46 Atazanavir Sulfate Phase 4,Phase 2
47
Bilirubin Phase 4,Phase 2 635-65-4 5280352
48 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
49 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
50 Dermatologic Agents Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 95)
id Name Status NCT ID Phase
1 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
3 Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery Completed NCT02729285 Phase 4
4 Atazanavir/Ritonavir and Zinc Pharmacokinetic Study Completed NCT01475227 Phase 4
5 Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study Completed NCT00698438 Phase 4
6 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4
7 Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma Completed NCT00444080 Phase 4
8 Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery Completed NCT00538590 Phase 4
9 Comparative Study of the Safety and Effectiveness of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery Completed NCT01440751 Phase 4
10 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4
11 Topical Jelly and Intracameral Anesthesia Versus Subtenon Anesthesia, in Cataract Surgery Withdrawn NCT01344252 Phase 4
12 Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery Withdrawn NCT01326585 Phase 4
13 Comparison Amongst Scleral, Corneal and Amniotic Membrane Grafts to Restore Scleral Thinning Unknown status NCT00801073 Phase 2, Phase 3
14 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
15 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
16 Ologen(Oculusgen)-Glaucoma and Pterygium Historical Control Study in China Shanghai Sixth People's Hospital Unknown status NCT00478790 Phase 3
17 Goniocurettage as First Choice of Surgical Treatment in Chronic Open-Angle Glaucoma: Outcomes and Complications Unknown status NCT01511094 Phase 2, Phase 3
18 Oculusgen (Ologen) Collagen Matrix Implant for Phaco-Trabeculectomy in Primary Glaucoma: A Case-Control Study Unknown status NCT00687791 Phase 3
19 Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation Completed NCT01068379 Phase 3
20 To Compare Fibrin Glue and Suture in Primary Pterygium Excision With Amniotic Membrane Transplantation Completed NCT00457223 Phase 2, Phase 3
21 Ologen (OculusGen)-Glaucoma MMC Control in Pakistan Completed NCT00472810 Phase 3
22 Lucentis Versus Mitomycin C During Glaucoma Surgery Completed NCT00626782 Phase 2, Phase 3
23 Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma Completed NCT02901236 Phase 2, Phase 3
24 Does Adding Bevacizumab Therapy in Glaucoma Surgery Improve the Success of Needle Bleb Revisions? Completed NCT00853073 Phase 2, Phase 3
25 InnFocus MicroShunt Versus Trabeculectomy Study Recruiting NCT01881425 Phase 2, Phase 3
26 Imaging Ahmed Glaucoma Tubes With a Pericardial Graft and Tissue Glue or Partial-Thickness Scleral Flap and Sutures Unknown status NCT00453024 Phase 2
27 Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery Unknown status NCT01297803 Phase 2
28 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2
29 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
30 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2
31 Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2
32 A Pilot Study Of A Novel Treatment Regimen, Maraviroc + Ritonavir Boosted Atazanavir, In Treatment Naive HIV-Infected Patients Completed NCT00827112 Phase 2
33 Study Assessing Two Models of Hypofractionated Protontherapy on Large Choroidal Melanomas Recruiting NCT02602756 Phase 2
34 Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting Recruiting NCT03041883 Phase 1, Phase 2
35 A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration Active, not recruiting NCT01226628 Phase 1, Phase 2
36 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2
37 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1
38 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1
39 Assessment of Fibrin Glue in Pterygium Surgery and Other Forms of External Eye Surgery Completed NCT00344201 Phase 1
40 Clinical Study of the Safety and Performance of the Miami InnFocus Drainage Implant to Relieve Glaucoma Symptoms Completed NCT00772330 Phase 1
41 Clinical Trial of Intravitreal Injection of Autologous Bone Marrow Stem Cells in Patients With Retinitis Pigmentosa Completed NCT02280135 Phase 1
42 Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Active, not recruiting NCT02121171 Phase 1
43 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1
44 The Application of Oral Mucosal Epithelial Cell Sheets Cultivated on Amino Membrane in Patients Suffering From Corneal Stem Cell Insufficiency or Symblepharon. Terminated NCT00491959 Phase 1
45 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963
46 The Influence of Postoperative Postures on Persistent Sub-foveal Fluid After Scleral Buckle Surgery Unknown status NCT02294708
47 Axial Length Change in Eyes Treated by Silicone Sponge Scleral Buckling Unknown status NCT01647373
48 IRay to Treat Polypoidal Choroidal Vasculopathy (PCV) Secondary to Age-Related Macular Degeneration (AMD Unknown status NCT01516294
49 The Results of Ahmed Valve Operations Unknown status NCT00193960
50 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

Genetic Tests for Scleral Disease

Anatomical Context for Scleral Disease

MalaCards organs/tissues related to Scleral Disease:

39
Eye

Publications for Scleral Disease

Articles related to Scleral Disease:

id Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951

Variations for Scleral Disease

Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

Pathways for Scleral Disease

GO Terms for Scleral Disease

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apoptotic signaling pathway GO:0097190 9.32 TNF TNFRSF1B
2 regulation of cell migration GO:0030334 9.26 PAX6 SRCIN1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
4 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Molecular functions related to Scleral Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 8.8 MAPKAP1 PAX6 SRCIN1

Sources for Scleral Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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