Aliases & Classifications for Scleral Disease

MalaCards integrated aliases for Scleral Disease:

Name: Scleral Disease 12 14
Scleral Diseases 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11343
ICD10 33 H15 H15.9
MeSH 42 D015422
NCIt 47 C79717
SNOMED-CT 64 33064008
UMLS 69 C0036412

Summaries for Scleral Disease

MalaCards based summary : Scleral Disease, also known as scleral diseases, is related to mitochondrial encephalomyopathy and glaucomatocyclitic crisis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Lidocaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye and thyroid.

Related Diseases for Scleral Disease

Diseases related to Scleral Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 mitochondrial encephalomyopathy 10.5 MRAP SRCIN1
2 glaucomatocyclitic crisis 10.5 MRAP TNFRSF1B
3 plasmodium falciparum malaria 10.5 MRAP TNFRSF1B
4 primary lacrimal atrophy 10.5 MRAP TNFRSF1B
5 prostate calculus 10.4 MRAP TNF
6 tularemia 10.4 MRAP TNF
7 cardiac sarcoidosis 10.4 TNF TNFRSF1B
8 lung disease 10.4 TNF TNFRSF1B
9 multiple epiphyseal dysplasia 10.3 TNF TNFRSF1B
10 cerebellum cancer 10.3 TNF TNFRSF1B
11 neuromuscular disease 10.3 TNF TNFRSF1B
12 morphine dependence 10.3 IL1RN TNFRSF1B
13 multiple sclerosis 5 10.3 TNF TNFRSF1B
14 primary biliary cirrhosis 10.3 TNF TNFRSF1B
15 peripheral nervous system disease 10.3 TNF TNFRSF1B
16 sublingual gland cancer 10.2 SRCIN1 TNF
17 crest syndrome 10.2 TNF TNFRSF1B
18 walker dyson syndrome 10.2 IL1RN TNF
19 indolent myeloma 10.2 IL1RN TNF
20 senile reticular retinal degeneration 10.2 IL1RN TNF
21 choreatic disease 10.2 TNF TNFRSF1B
22 benign neonatal seizures 10.2 IL1RN TNF
23 keloids 10.2 IL1RN TNF
24 noma 10.1 IL1RN TNF
25 osmotic diarrhea 10.1 IL1RN TNF
26 iida kannari syndrome 10.1 IL1RN TNF
27 tibialis tendinitis 10.1 IL1RN TNF
28 esophagus melanoma 10.1 IL1RN TNF
29 extrahepatic bile duct papillary adenoma 10.1 IL1RN TNF
30 sinusitis 10.0 IL1RN TNF
31 dermatosis papulosa nigra 10.0 MRAP TNF TNFRSF1B
32 discitis 10.0 MRAP TNF TNFRSF1B
33 cryptococcosis 10.0 MRAP TNF TNFRSF1B
34 patau syndrome 10.0 MRAP TNF TNFRSF1B
35 autosomal recessive type iv ehlers-danlos syndrome 10.0 IL1RN TNF
36 endometrial clear cell adenocarcinoma 10.0 MRAP TNF TNFRSF1B
37 plantar fascial fibromatosis 10.0 IL1RN TNF
38 intestinal disaccharidase deficiency 10.0 IL1RN TNF
39 retinal vascular occlusion 9.9 IL1RN TNF
40 inflammatory bowel disease 3 9.9 TNF TNFRSF1B
41 pleomorphic lipoma 9.9 IL1RN TNF
42 scleroperikeratitis 9.8 IL1RN TNF TNFRSF1B
43 early congenital syphilis 9.8 IL1RN TNF TNFRSF1B
44 muscle tissue disease 9.8 TNF TNFRSF1B
45 ragweed sensitivity 9.8 IL1RN TNF
46 atherosclerosis 9.8 IL1RN TNF TNFRSF1B
47 inclusion conjunctivitis 9.7 IL1RN MRAP SRCIN1 TNFRSF1B
48 rheumatoid arthritis 9.5
49 arthritis 9.5
50 rheumatic disease 9.5

Graphical network of the top 20 diseases related to Scleral Disease:



Diseases related to Scleral Disease

Symptoms & Phenotypes for Scleral Disease

UMLS symptoms related to Scleral Disease:


eye manifestations

Drugs & Therapeutics for Scleral Disease

Drugs for Scleral Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
5
Zinc Approved Phase 4 7440-66-6 32051 23994
6 Zinc sulfate Approved Phase 4 7733-02-0
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
8
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
9 Anesthetics Phase 4
10 Anesthetics, Local Phase 4
11 Anti-Arrhythmia Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 Diuretics, Potassium Sparing Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 1
15 Sodium Channel Blockers Phase 4
16 Antirheumatic Agents Phase 4,Phase 1,Phase 2
17 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
18 triamcinolone acetonide Phase 4,Phase 3
19 Triamcinolone diacetate Phase 4,Phase 3
20 Triamcinolone hexacetonide Phase 4,Phase 3
21 Adrenocorticotropic Hormone Phase 4
22 beta-endorphin Phase 4
23 Hormone Antagonists Phase 4,Phase 2,Phase 1
24 Hormones Phase 4,Phase 2,Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
26 Melanocyte-Stimulating Hormones Phase 4
27 Analgesics Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Cyclooxygenase Inhibitors Phase 4
32 Ketorolac Tromethamine Phase 4
33 Anti-HIV Agents Phase 4
34 Anti-Infective Agents Phase 4,Phase 1,Phase 2
35 Anti-Retroviral Agents Phase 4
36 Antiviral Agents Phase 4
37 Astringents Phase 4
38 Atazanavir Sulfate Phase 4
39
Bilirubin Phase 4 635-65-4 5280352
40 Cytochrome P-450 CYP3A Inhibitors Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Dermatologic Agents Phase 4,Phase 1,Phase 2
43 HIV Protease Inhibitors Phase 4,Phase 1
44 Micronutrients Phase 4,Phase 1,Phase 2
45
protease inhibitors Phase 4,Phase 1
46 Trace Elements Phase 4,Phase 1,Phase 2
47 glucocorticoids Phase 4,Phase 2,Phase 1
48 Ophthalmic Solutions Phase 4,Phase 1
49 Pharmaceutical Solutions Phase 4,Phase 1
50 Antiemetics Phase 4,Phase 1

Interventional clinical trials:

(show top 50) (show all 63)

id Name Status NCT ID Phase Drugs
1 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery Completed NCT02729285 Phase 4 Ketorolac Tromethamine;placebo
4 Atazanavir/Ritonavir and Zinc Pharmacokinetic Study Completed NCT01475227 Phase 4 1 Solvazinc tablet, day 2 to day 15;1 Solvazinc tablet, day 15 to day 28
5 Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study Completed NCT00698438 Phase 4
6 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
7 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
8 Topical Jelly and Intracameral Anesthesia Versus Subtenon Anesthesia, in Cataract Surgery Withdrawn NCT01344252 Phase 4 Lidocaine
9 Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery Withdrawn NCT01326585 Phase 4 Dexamethasone Sodium Phosphate Injection;Saline Injection
10 Comparison Amongst Scleral, Corneal and Amniotic Membrane Grafts to Restore Scleral Thinning Unknown status NCT00801073 Phase 2, Phase 3
11 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
12 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
13 Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation Completed NCT01068379 Phase 3
14 To Compare Fibrin Glue and Suture in Primary Pterygium Excision With Amniotic Membrane Transplantation Completed NCT00457223 Phase 2, Phase 3
15 Imaging Ahmed Glaucoma Tubes With a Pericardial Graft and Tissue Glue or Partial-Thickness Scleral Flap and Sutures Unknown status NCT00453024 Phase 2
16 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
17 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
18 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
19 A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration Completed NCT01226628 Phase 1, Phase 2
20 Study Assessing Two Models of Hypofractionated Protontherapy on Large Choroidal Melanomas Recruiting NCT02602756 Phase 2
21 Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting Recruiting NCT03041883 Phase 1, Phase 2
22 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
23 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
24 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
25 Assessment of Fibrin Glue in Pterygium Surgery and Other Forms of External Eye Surgery Completed NCT00344201 Phase 1
26 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
27 The Application of Oral Mucosal Epithelial Cell Sheets Cultivated on Amino Membrane in Patients Suffering From Corneal Stem Cell Insufficiency or Symblepharon. Terminated NCT00491959 Phase 1
28 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
29 The Influence of Postoperative Postures on Persistent Sub-foveal Fluid After Scleral Buckle Surgery Unknown status NCT02294708
30 Axial Length Change in Eyes Treated by Silicone Sponge Scleral Buckling Unknown status NCT01647373
31 IRay to Treat Polypoidal Choroidal Vasculopathy (PCV) Secondary to Age-Related Macular Degeneration (AMD Unknown status NCT01516294
32 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567
33 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823
34 Human Samples and Data Repository Completed NCT00539370
35 The Effect of Hyperbilirubinemia on CV Disease, Neurocog Function and Renal Function Completed NCT01475240
36 Scleral Self-indentation Chandelier-assisted Peripheral Vitrectomy Under Air Rhegmatogenous Retinal Detachment. Completed NCT03218371
37 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
38 Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Completed NCT02528045
39 Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity Completed NCT00000133
40 Macular Function After Scleral Buckle Completed NCT00345007
41 Trial of the PresView Implant for the Improvement of Near Vision in Patients With Presbyopia Completed NCT01166568
42 Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment Completed NCT01639209
43 Corneal Changes After Retinal Surgery Completed NCT01446367
44 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580
45 Trial of the PresView Implant for the Improvement of Near Vision in Presbyopic Patients Completed NCT01933750
46 Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT03208205
47 Scleral Response to Intraocular Pressure (IOP) Completed NCT03267862
48 UK Surveillance of Treated Retinopathy of Prematurity Completed NCT02484989
49 Primary Vitrectomy for the Treatment of Retinal Detachment in Highly Myopic Completed NCT01480505
50 Neural Mechanisms Engaged in Control of Eye Movements Recruiting NCT00999934

Search NIH Clinical Center for Scleral Disease

Cochrane evidence based reviews: scleral diseases

Genetic Tests for Scleral Disease

Anatomical Context for Scleral Disease

MalaCards organs/tissues related to Scleral Disease:

39
Eye, Thyroid

Publications for Scleral Disease

Articles related to Scleral Disease:

id Title Authors Year
1
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. ( 7671613 )
1995
2
Ultrasound biomicroscopy in the assessment of anterior scleral disease. ( 8238225 )
1993
3
Progression of scleral disease. ( 2052300 )
1991
4
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. ( 3443202 )
1987
5
Rheumatic disease in patients suffering from scleral disease. ( 5427425 )
1970
6
Management of scleral disease. ( 5226566 )
1966
7
Slitlamp diagnosis of corneal and scleral disease. ( 13080411 )
1953
8
Some contemporary concepts of scleral disease. ( 14902177 )
1951

Variations for Scleral Disease

Expression for Scleral Disease

Search GEO for disease gene expression data for Scleral Disease.

Pathways for Scleral Disease

GO Terms for Scleral Disease

Biological processes related to Scleral Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 IL1RN TNF TNFRSF1B
2 apoptotic signaling pathway GO:0097190 9.37 TNF TNFRSF1B
3 response to glucocorticoid GO:0051384 9.32 IL1RN TNF
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.16 TNF TNFRSF1B
5 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Sources for Scleral Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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