Scleritis malady

Wikipedia: Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as...⁴⁴ more...

MalaCards: Scleritis, also known as unspecified scleritis (disorder), is related to posterior scleritis and uveitis. An important gene associated with Scleritis is MIR4273 (microRNA 4273), and among its related pathways are Graft-versus-host disease and OX40 Pathway. The drug medrysone and the compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Descriptions:

scleritis 6 8 43 unspecified scleritis (disorder) 6

scleritis, unspecified 6 scleritis (disorder) 6

Diseases related to scleritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 523)

id	Related Disease	Score	Top Affiliating Genes
1	posterior scleritis	31.8	MIR4273, NSMAF
2	uveitis	25.3	IL4, IL5, CCL2, IFNG, HLA-B, TNF
3	rheumatoid arthritis	22.1	MMP9, IL1RAPL2, IL4, IL5, CCL2, IFNG
4	arthritis	22.1	MMP9, IL1RAPL2, IL4, IL5, CCL2, IFNG
5	spondylarthropathy	13.2	IL1RAPL2, TNF
6	egg allergy	13.1	IL4, IL5
7	idiopathic myopathy	13.1	CCL2, HLA-B
8	rheumatoid vasculitis	13.1	IL1RAPL2, TNF
9	palindromic rheumatism	13.1	TNF, TNFRSF1B
10	schnitzler syndrome	13.1	IL1RAPL2, TNF
11	psoriatic arthritis	13.1	IL1RAPL2, TNF
12	cough variant asthma	13.1	IL4, IL5
13	mycobacterium tuberculosis	13.1	CCL2, TNF
14	allergic bronchopulmonary aspergillosis	13.1	IL4, IL5
15	bagassosis	13.1	IL5, TNF
16	allergic conjunctivitis	13.1	IL4, IL5
17	sympathetic ophthalmia	13.1	CCL2, TNF
18	b cell deficiency	13.1	IL4, IL5
19	intrinsic asthma	13.1	IL4, IL5
20	blau syndrome	13.0	IL1RAPL2, TNF
21	sapho syndrome	13.0	HLA-B, TNF
22	sorsby fundus dystrophy	13.0	MMP9, TIMP1
23	asthma	13.0	IL4, IL5
24	microcystic meningioma	13.0	MMP9, TIMP1
25	primary systemic mycosis	13.0	IL4, TNF
26	kimura disease	13.0	IL4, IL5
27	nephropathia epidemica	12.9	HLA-B, TNF
28	rapidly progressive glomerulonephritis	12.9	CCL2, TNF, PRTN3
29	post-transplant lymphoproliferative disease	12.9	TNF, TNFRSF1B
30	juvenile rheumatoid arthritis	12.9	IL1RAPL2, TNF, TNFRSF1B
31	dengue shock syndrome	12.9	IL1RAPL2, CCL2, TNF
32	pulpitis	12.9	TNF, TIMP1
33	mixed connective tissue disease	12.9	TNF, TNFRSF1B, PRTN3
34	diffuse panbronchiolitis	12.9	IL1RAPL2, IL5, TNF
35	panbronchiolitis	12.9	IL1RAPL2, IL5, TNF
36	pulmonary edema	12.9	IL1RAPL2, TNF, TNFRSF1B
37	joint disorders	12.9	IL1RAPL2, TNF, TIMP1
38	crescentic glomerulonephritis	12.9	CCL2, TNF, PRTN3
39	obstructive jaundice	12.8	IL1RAPL2, CCL2, TNF
40	conjunctivochalasis	12.8	MMP9, TIMP1
41	eosinophilic fasciitis	12.8	IL5, IFNG
42	septic shock	12.8	IL1RAPL2, TNF, TNFRSF1B
43	paranasal sinus disease	12.8	IL5, IFNG
44	pleural tuberculosis	12.8	CCL2, IFNG
45	poems syndrome	12.8	IL5, TNF, TIMP1
46	temporal arteritis	12.8	CCL2, IFNG
47	urethritis	12.8	MIR4273, HLA-B, TNF
48	eosinophilia-myalgia syndrome	12.7	IL5, IFNG
49	behcet's disease	12.7	HLA-B, TNF, TNFRSF1B
50	chronic sphenoidal sinusitis	12.7	IL4, IL5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 medrysone

MalaCards organs/tissues related to scleritis:

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MGI Mouse Phenotypes related to scleritis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	IL5, NSMAF
2	liver/biliary system phenotype	MP:0005370	9.7	IFNG
3	skeleton phenotype	MP:0005390	9.5	MMP9, TNFRSF1B
4	homeostasis/metabolism phenotype	MP:0005376	9.2	NSMAF, TNFRSF1B, CCL2, IL5
5	immune system phenotype	MP:0005387	8.8	IFNG, TNF, PRTN3, NSMAF
6	digestive/alimentary phenotype	MP:0005381	8.8	IFNG, CCL2, MMP9
7	integument phenotype	MP:0010771	8.7	NSMAF, TNFRSF1B, IFNG, IL4
8	tumorigenesis	MP:0002006	7.3	TIMP1, TNFRSF1B, TNF, IFNG, CCL2, IL5
9	reproductive system phenotype	MP:0005389	7.1	TIMP1, TNF, IFNG, CCL2, IL4, MMP9
10	vision/eye phenotype	MP:0005391	7.0	TNFRSF1B, TNF, IFNG, CCL2, IL4, MMP9

Articles related to scleritis:

id	Title	Authors	Year	Affiliating Genes
1	Scleritis and multiple systemic autoimmune manifestat ions in chronic natural killer cell lymphocytosis associated with elevated TCRa lpha/beta+CD3+CD4-CD8- double-negative T cells. (20508050)	Yeh S.... Nussenblatt R.B.	2010	TNF, CCL2, IL4
2	Efficacy of the IL-1 receptor antagonist, anakinra, f or the treatment of diffuse anterior scleritis in rheumatoid arthritis. Report of two cases. (17449489)	Botsios C.... Punzi L.	2007	IL1RAPL2
3	TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. (17496900)	Amadi-Obi A.... Egwuagu C.E.	2007	IFNG
4	Expression of tumor necrosis factor alpha and matrix metalloproteinase-9 in surgically induced necrotizing scleritis. (16319517)	Seo K.Y.... Lee J.H.	2006	MMP9
5	Tumor necrosis factor alpha blockade with infliximab for refractory uveitis and scleritis. (15019389)	Murphy C.C.... Jayne D.	2004	TNF
6	Increased expression of matrix metalloproteinases in vivo in scleritis tissue and in vitro in cultured human scleral fibroblasts. (9033278)	Di Girolamo N.... Wakefield D.	1997	TIMP1

Genes related to scleritis according to GeneCards:

(show all 13)

id	Symbol	Description	Score	GeneCards Section Context
1	MIR4273	microRNA 4273	11.0
2	NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor	11.0
3	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
4	PRTN3	proteinase 3	11.0
5	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0
6	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
7	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
8	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
9	HLA-B	major histocompatibility complex, class I, B	11.0
10	IL4	interleukin 4	11.0	Publications
11	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
12	IFNG	interferon, gamma	11.0	Publications
13	TNF	tumor necrosis factor	11.0	Publications

Pathways related to scleritis according to GeneDecks:

(show all 43)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.3	HLA-B
2	OX40 Pathway36	10.0	IL4, IL5
3	Endothelin-1 Signaling Pathway36	9.8	IL4, IL5
4	Molecular Mechanisms of Cancer36	9.8	IL5, TNFRSF1B, TIMP1
5	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL5, IL4
6	Fc epsilon RI signaling pathway20	9.6	IL4, TNF
7	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.6	TNF, TNFRSF1B
8	PGC1Alpha Pathway36	9.6	TNFRSF1B, IL5, IL4
9	ERK Signaling36	9.5	TIMP1, IL5, IL4
10	Akt Signaling36	9.4	TNF, CCL2, IL4
11	Asthma20	9.4	TNF, IL5, IL4
12	Autoimmune thyroid disease20	9.4	IL4, IL5, HLA-B
13	LDL Oxidation in Atherogenesis36	9.2	CCL2, TNF
14	Hematopoietic cell lineage20	9.2	TNF, IL5, IL4
15	Cellular Transformation by HTLV136	9.2	IFNG, TNF, TNFRSF1B
16	Glucocorticoid Receptor Signaling36	9.1	TNFRSF1B, CCL2, IL5, IL4
17	NFAT Signaling and Lymphocyte Interactions36	9.1	IL4, IL5, CCL2
18	MSP-RON Signaling36	9.0	TNF, IFNG, CCL2
19	MIF Mediated Glucocorticoid Regulation36	9.0	TNF, CCL2, IL5, IL4
20	Malaria20	9.0	CCL2, IFNG, TNF
21	MIF Regulation of Innate Immune Cells36	9.0	TNF, CCL2, IL5, IL4
22	all-trans-Retinoic Acid Signaling in Brain36	9.0	TNF, CCL2, IL5, IL4
23	Type I diabetes mellitus20	9.0	IFNG, HLA-B, TNF
24	PEDF Induced Signaling36	9.0	TNF, CCL2, IL5, IL4
25	TGF-Beta Pathway36	8.9	IL4, IL5, CCL2, TNFRSF1B, TIMP1
26	Rheumatoid arthritis20	8.9	CCL2, IFNG, TNF
27	Leishmaniasis20	8.8	IL4, IFNG, TNF
28	Chagas disease (American trypanosomiasis)20	8.8	CCL2, IFNG, TNF
29	STAT3 Pathway36	8.7	IL4, IL5, CCL2, TNF, TNFRSF1B
30	IL-6 Pathway36	8.7	TIMP1, TNF, CCL2, IL5, IL4
31	THC Differentiation Pathway36	8.7	TNFRSF1B, TNF, IFNG, IL4
32	PAK Pathway36	8.7	TIMP1, TNF, CCL2, IL5, IL4
33	Cytokine Network36	8.7	TNF, IFNG, IL5, IL4
34	T cell receptor signaling pathway20	8.6	TNF, IFNG, IL5, IL4
35	Immune response CD16 signaling in NK cells10	8.6	TNF, IFNG, IL4
36	Rho Family GTPases36	8.6	TIMP1, TNF, CCL2, IL5, IL4
37	MAPK Family Pathway36	8.4	TIMP1, TNFRSF1B, TNF, CCL2, IL5, IL4
38	Tec Kinases Signaling36	8.4	TIMP1, TNFRSF1B, TNF, CCL2, IL5, IL4
39	Antioxidant Action of Vitamin-C36	8.4	TIMP1, TNFRSF1B, TNF, CCL2, IL5, IL4
40	p38 Signaling36	8.4	TIMP1, TNFRSF1B, TNF, CCL2, IL5, IL4
41	Allograft rejection20	8.2	IL4, IL5, IFNG, HLA-B, TNF
42	JAK-STAT Pathway36	8.1	TIMP1, TNFRSF1B, IFNG, CCL2, IL5, IL4
43	Cytokine-cytokine receptor interaction20	7.9	TNFRSF1B, TNF, IFNG, CCL2, IL5, IL4

Compounds related to scleritis according to GeneDecks:

(show top 50)    (show all 141)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.6	IL1RAPL2
2	endotoxin32	10.2	IL1RAPL2, TNFRSF1B
3	ionomycin32	10.0	IL5
4	pge232	9.9	TNFRSF1B, IL5, IL1RAPL2
5	bleomycin32 9 9	11.5	IL4, IL5, CCL2
6	vegf32	8.9	CCL2, TNFRSF1B, TIMP1, IL1RAPL2, MMP9
7	amphotericin b32	8.8	IL4, IL1RAPL2, IL5, IFNG
8	imiquimod32 42 9 9	11.8	TNF, IFNG, IL5, IL1RAPL2
9	interferon gamma32	8.8	IFNG, IL4, TNF
10	tranilast32	8.7	MMP9, IFNG, TIMP1
11	con a32	8.7	IFNG, IL5, TNFRSF1B, IL4
12	fmlp32	8.6	TNFRSF1B, CCL2, IL1RAPL2, IL5, PRTN3, TNF
13	etanercept32 9 9	10.6	IFNG, TNF, TIMP1, TNFRSF1B, IL1RAPL2
14	leukotriene b432 42 18	10.6	IL1RAPL2, MMP9, TNF, CCL2, IL5
15	sb 20358032 42	9.6	MMP9, IFNG, TNF, TIMP1
16	rolipram32 42	9.5	IL5, IL4, TNF, IFNG
17	tgf beta132	8.5	TNF, TIMP1, MMP9, IL1RAPL2, CCL2
18	methylcellulose32	8.5	IL5, IFNG, IL4, TIMP1
19	polymyxin b32	8.5	IL4, CCL2, IFNG, TNF
20	parthenolide32	8.4	IFNG, CCL2, MMP9, TNF
21	neopterin32	8.4	TNF, IL1RAPL2, IFNG, TNFRSF1B, IL4
22	poly(i-c)32	8.3	TNF, IL4, IFNG, IL5
23	methotrexate32 34 42 9 9	12.3	TNFRSF1B, MMP9, TIMP1, IL1RAPL2, IL5, TNF
24	il-1232	8.3	TNF, CCL2, IL4, IL5, IFNG
25	gm-csf32	8.2	IFNG, TNF, IL4, CCL2, IL5
26	tarc32	8.2	IL4, IFNG, TNF, CCL2, IL5
27	polyinosinic-polycytidylic acid32	8.2	TNF, HLA-B, IFNG, IL5, IL4
28	rosiglitazone32 9 18 9	11.2	MMP9, CCL2, TNF, TIMP1, IL1RAPL2, IL4
29	ly29400232	8.1	MMP9, TNFRSF1B, TIMP1, IL4, CCL2, TNF
30	fibrinogen32	8.1	MMP9, IL1RAPL2, CCL2, TNFRSF1B, HLA-B, TNF
31	fluticasone propionate32 42 9 9	11.0	IL5, TNF, IFNG, IL4, MMP9
32	curcumin32	8.0	TNF, MMP9, TNFRSF1B, TIMP1, CCL2
33	pdtc32	7.9	IFNG, CCL2, IL4, TNF, MMP9
34	indomethacin32 9 9	9.9	IL5, IL1RAPL2, IL4, IFNG, TIMP1, TNF
35	infliximab32 9 9	9.8	IL4, PRTN3, TIMP1, TNFRSF1B, TNF, IFNG
36	adenylate32	7.8	IL1RAPL2, TIMP1, TNFRSF1B, IL5, MMP9, IL4
37	tacrolimus32 34 9 9	10.8	IL5, HLA-B, TNF, TIMP1, IL4, IFNG
38	paraffin32	7.7	MMP9, TIMP1, HLA-B, CCL2, IL4, IL5
39	simvastatin32 34 42 9 18 9	12.7	IL1RAPL2, TNF, IL4, CCL2, MMP9, IFNG
40	il 1032	7.7	TNF, IL1RAPL2, IL4, TNFRSF1B, IFNG, CCL2
41	histamine32 18	8.6	TIMP1, TNF, IFNG, CCL2, IL5, IL4
42	genistein32 9 18 9	10.4	MMP9, TIMP1, TNF, CCL2, IFNG, PRTN3
43	herbimycin a32 42	8.3	MMP9, IL4, IL5, CCL2, IFNG, TNF
44	actinomycin d32	7.1	MMP9, CCL2, IFNG, TNF, TNFRSF1B, IL1RAPL2
45	serine32	7.0	CCL2, HLA-B, TNF, IL1RAPL2, IL5, PRTN3
46	retinoic acid32 42 18	8.8	HLA-B, TNF, TNFRSF1B, PRTN3, TIMP1, IFNG
47	cyclosporin a32 42	7.6	MMP9, IL5, IL4, IFNG, HLA-B, IL1RAPL2
48	cycloheximide32	6.4	IL5, IL4, IL1RAPL2, CCL2, IFNG, TNF
49	rantes32	6.2	TIMP1, MMP9, CCL2, HLA-B, IL5, IL4
50	dexamethasone32 42 34 9 9	10.2	IFNG, TIMP1, CCL2, MMP9, IL5, IL4

Cellular components related to scleritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.2	MMP9, IL4, IL5, CCL2, IFNG, TNF

Biological processes related to scleritis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of podosome assembly	GO:071803	9.8	IL5, TNF
2	positive regulation of synaptic transmission	GO:050806	9.4	TNF, CCL2
3	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	TNF, IFNG
4	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.4	IFNG, TNF
5	positive regulation of isotype switching to IgG isotypes	GO:048304	9.3	IFNG, IL4
6	positive regulation of MHC class II biosynthetic process	GO:045348	9.2	IL4, IFNG
7	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.2	IL4, IL5, TNF
8	response to mechanical stimulus	GO:009612	9.2	TNF, CCL2, MMP9
9	cellular response to lipopolysaccharide	GO:071222	9.1	TNFRSF1B, IFNG, CCL2
10	positive regulation of osteoclast differentiation	GO:045672	9.1	IFNG, TNF
11	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.1	IFNG, TNF, TNFRSF1B
12	humoral immune response	GO:006959	9.0	TNF, IFNG, CCL2
13	response to ethanol	GO:045471	9.0	CCL2, IL4, MMP9
14	positive regulation of chemokine biosynthetic process	GO:045080	8.9	IL4, IFNG, TNF
15	inflammatory response	GO:006954	8.9	IL5, CCL2, TNF, TNFRSF1B
16	negative regulation of growth of symbiont in host	GO:044130	8.8	IFNG, TNF
17	cytokine-mediated signaling pathway	GO:019221	8.6	IL5, CCL2, IFNG, HLA-B
18	response to drug	GO:042493	7.9	TNF, IFNG, CCL2, IL4, MMP9

Molecular functions related to scleritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.2	IL4, IL5, IFNG, TNF