MCID: SCL015
MIFTS: 50

Scleritis malady

Eye category

Summaries for Scleritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

MalaCards: Scleritis, also known as scleritis, unspecified, is related to uveitis and arthritis. An important gene associated with Scleritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Leishmaniasis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug medrysone and the compounds pge2 and endotoxin have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and vision/eye.

Aliases & Classifications for Scleritis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

scleritis 8 10 61
scleritis, unspecified 8
unspecified scleritis 8


External Ids:

Disease Ontology8 DOID:13452
MeSH35 D015423
ICD9CM27 379.00
ICD1025 H15.0

Related Diseases for Scleritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Scleritis family:

posterior scleritis anterior scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 340)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.6IL4, TNFRSF1B, CCL2, IFNG, HLA-B, TNF
2arthritis30.6TNF, TIMP1
3wegener's granulomatosis30.4PRTN3
4vasculitis30.2CCL2, TNFRSF1B, TNF, HLA-B, PRTN3, IL1RAPL2
5crohn's disease30.0TNF, TNFRSF1B
6tuberculosis30.0TNF, IL4, TNFRSF1B, IFNG, IL1RAPL2
7hepatitis c30.0IFNG, IL4, TNFRSF1B, TNF, TIMP1
8behcet's disease29.9TNFRSF1B, TNF, HLA-B
9squamous cell carcinoma29.9TNFRSF1B, MMP9, IL1RAPL2, TIMP1, PRTN3, HLA-B
10urticaria29.7IL1RAPL2
11polymyalgia rheumatica29.7IL1RAPL2
12familial mediterranean fever29.7TNF
13blau syndrome29.7TNF
14acquired immunodeficiency syndrome29.7HLA-B
15vascular disease29.7TIMP1, TNF
16allergic conjunctivitis29.7IL5, IL4
17sjogren's syndrome29.7TNFRSF1B, IL1RAPL2, PRTN3
18lepromatous leprosy29.7IFNG, IL4
19psoriatic arthritis29.7TNFRSF1B, TNF, IL1RAPL2
20kawasaki disease29.7MMP9, CCL2, TIMP1
21toxic shock syndrome29.7TNF, IFNG
22reactive arthritis29.7HLA-B, PRTN3
23graft versus host disease29.7IFNG, IL1RAPL2, IL4, TNF
24ankylosing spondylitis29.7IL1RAPL2, TNFRSF1B, TNF, HLA-B, PRTN3
25ulcerative colitis29.6TNFRSF1B, TNF, IL1RAPL2, IL4, IFNG, PRTN3
26posterior scleritis10.8
27anterior scleritis10.6
28n syndrome10.3
29strabismus10.3
30brawny scleritis10.2
31relapsing polychondritis10.2
32cryoglobulinemia10.1
33nodular episcleritis10.1
34cogan's syndrome10.1
35necrobiotic xanthogranuloma10.1
36orbital cellulitis10.1
37cellulitis10.1
38syphilis10.1
39acute febrile neutrophilic dermatosis10.1
40anterior uveitis10.1
41stenotrophomonas maltophilia10.1
42acute pancreatitis10.0IL1RAPL2
43myocardial infarction10.0IL1RAPL2
44cystic fibrosis10.0PRTN3
45myeloid leukemia10.0PRTN3
46bronchiolitis10.0IL5
47keratoconjunctivitis10.0IL5
48filariasis10.0IL5
49esophagitis10.0IL5
50bronchopulmonary dysplasia10.0TIMP1

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to scleritis

Clinical Features for Scleritis

Drugs & Therapeutics for Scleritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Scleritis

Drug clinical trials:

Search ClinicalTrials for Scleritis

Search NIH Clinical Center for Scleritis

Search CenterWatch for Scleritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Scleritis

Anatomical Context for Scleritis

Animal Models for Scleritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Scleritis

Sources:
51PubMed
See all sources

Articles related to Scleritis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Epidemiology and visual outcomes in patients with infectious scleritis. (22902495)
2013
2
Contact lens-associated nocardial necrotizing scleritis. (23908577)
2013
3
Incidence and prevalence of episcleritis and scleritis in Northern California. (24145628)
2013
4
Ocular hypertension and glaucoma incidence in patients with scleritis. (22820814)
2013
5
Necrobiotic xanthogranuloma associated with necrotizing scleritis. (22814320)
2012
6
Scleritis--Wegener's granulomatosis. (23256431)
2012
7
Amniotic membrane transplantation in surgically induced necrotizing scleritis with peripheral ulcerative keratitis. (23248548)
2012
8
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. (22411459)
2012
9
Scleritis and episcleritis. (22858029)
2012
10
Clinical characteristics of a large cohort of patients with scleritis and episcleritis. (21963265)
2012
11
Posterior scleritis in children: clinical features and treatment. (22137553)
2012
12
Nocardia scleritis-clinical presentation and management: a report of three cases and review of literature. (21984396)
2012
13
Interferon-gamma release assay in tuberculous scleritis. (21402999)
2011
14
Adjunctive globe magnetic resonance imaging in the diagnosis of posterior scleritis. (21816252)
2011
15
Successful treatment of severe nodular scleritis with adalimumab. (20155432)
2010
16
Necrotizing scleritis following laser therapy for corneal vascularization. (19413229)
2009
17
Amitriptyline for pain control in scleritis may help to avoid excessive steroid use in selected cases: a case report. (19918461)
2009
18
Nodular scleritis following alendronate therapy. (18569796)
2008
19
Retrospective review of methotrexate therapy in the treatment of chronic, noninfectious, nonnecrotizing scleritis. (18282493)
2008
20
Posttraumatic Stenotrophomonas maltophilia infectious scleritis. (18216585)
2008
21
Acute unilateral anterior uveitis and scleritis following a single infusion of zoledronate for metastatic breast cancer. (18341464)
2008
22
Spontaneous filtration bleb as a consequence of scleritis. (17998526)
2007
23
Necrobiotic xanthogranuloma with posterior scleritis. (16682604)
2006
24
Posterior scleritis secondary to Pseudomonas aeruginosa keratitis. (16160510)
2005
25
Multifocal nodular episcleritis and scleritis with undiagnosed Hodgkin's lymphoma. (12750114)
2003
26
Anterior segment indocyanine green angiography in anterior scleritis and episcleritis. (13129874)
2003
27
Nodular scleritis in a patient with pyoderma gangrenosum. (12470160)
2002
28
Acute posterior multifocal placoid pigment epitheliopathy and scleritis in a patient with pANCA-positive systemic vasculitis. (11931797)
2002
29
Orbital lymphoma misdiagnosed as scleritis. (12466182)
2002
30
Surgically induced diffuse scleritis: comparison of incidence in phacoemulsification and conventional extracapsular cataract extraction. (12034697)
2002
31
Episcleritis and scleritis: clinical features and treatment results. (11024419)
2000
32
Use of topical steroid therapy in the management of nonnecrotizing anterior scleritis. (10396658)
1999
33
Recurrent nodular scleritis associated with varicella zoster virus. (9780109)
1998
34
Indocyanine green angiographic features in posterior scleritis. (9744391)
1998
35
Noninfectious necrotizing scleritis. (8778070)
1996
36
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
37
Aspergillus fumigatus scleritis. (8751132)
1995
38
Posterior scleritis--an unusual manifestation of Cogan's syndrome. (8055208)
1994
39
Infectious scleritis: report of four cases. (8334918)
1993
40
Scleritis in association with poststreptococcal vasculitis. (8216009)
1993
41
Necrotizing scleritis of scleral flaps after transscleral suture fixation of an intraocular lens. (1575226)
1992
42
Exudative retinal detachment and posterior scleritis associated with massive scleral thickening and calcification treated by scleral decompression. (1739704)
1992
43
Posterior scleritis related fundal mass in a patient with rheumatoid arthritis. (1439634)
1992
44
Prediction of response to treatment in patients with scleritis using a standardised scoring system. (1958366)
1991
45
Necrotizing scleritis secondary to conjunctival squamous cell carcinoma in acquired immunodeficiency syndrome. (2301539)
1990
46
Subretinal fluid in the diagnosis of posterior scleritis. (2261185)
1990
47
Role of testing for anticytoplasmic autoantibodies in the differential diagnosis of scleritis and orbital pseudotumor. (2388488)
1990
48
Scleritis as the presenting manifestation of procainamide-induced lupus. (2645552)
1989
49
Observations on long-term follow-up of posterior scleritis. (3706461)
1986
50
Scleromalacia perforans treated with cortisone; a clinical report with some remarks about ulcerative scleritis. (14398183)
1955

Genetic Variations for Scleritis

Expression for genes affiliated with Scleritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for genes affiliated with Scleritis

Sources:
30KEGG, 53R&D Systems, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Scleritis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL5
29.9IL4, IL5
39.7CCL2, TNF
4
Hide members
9.7IL5, TNFRSF1B, TIMP1
5
Hide members
9.7IL5, TNFRSF1B, TIMP1
6
Hide members
9.7TIMP1, TNFRSF1B, IL5
7
Hide members
9.6TIMP1, CCL2, IL5
89.5IFNG, IL5, IL4
99.5IFNG, IL5, IL4
109.5IL4, IL5, IFNG
11
Hide members
9.5MMP9, TNF, TIMP1
129.4TNF, IL5, IL4
13
Hide members
9.4TNF, TNFRSF1B, IFNG
14
Hide members
9.4TNF, TNFRSF1B, IFNG
15
Hide members
9.4TNF, TNFRSF1B, IFNG
169.3MMP9, TNF, IFNG
179.3CCL2, IFNG, TNF
189.3CCL2, IFNG, TNF
199.2IFNG, TNFRSF1B, IL5, IL4
209.1NSMAF, TNFRSF1B, TNF
21
Hide members
9.1MMP9, TNF, TNFRSF1B, CCL2
229.1CCL2, TNFRSF1B, TNF, MMP9
23
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9.1IFNG, TNF, IL5, IL4
249.1IL4, IL5, TNF, IFNG
25
Hide members
9.1IL4, IL5, TNF, IFNG
269.1CCL2, TNF, IL4, MMP9
27
Development PDGF signaling via STATs and NF-kB
Hide members
9.0TIMP1, CCL2, IFNG, TNF
28
Hide members
9.0CCL2, IFNG, TNF, MMP9
29
Hide members
8.7IFNG, TNF, HLA-B, IL5, IL4
30
Hide members
8.6IL4, HLA-B, TNF, IFNG, CCL2
31
Hide members
8.5TIMP1, CCL2, TNFRSF1B, TNF, IL5, IL4
32
Hide members
8.4IL4, IL5, HLA-B, TNF, TNFRSF1B, IFNG

Compounds for genes affiliated with Scleritis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Scleritis according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1pge24510.6MMP9
2endotoxin4510.6TNFRSF1B
3rosiglitazone45 50 29 11 2414.3TIMP1, IL4
4pdtc4510.2MMP9, CCL2
5cycloheximide4510.1IL1RAPL2
6gm-csf45 2911.1IFNG, TNF
7amphotericin b4510.0IL1RAPL2
8indomethacin45 60 29 1112.7IL5, IL1RAPL2
9tacrolimus45 50 1111.6IFNG, TIMP1, IL5, IL4
10con a459.5IFNG, TNFRSF1B, IL5, IL4
11ivig459.4TNFRSF1B, IL1RAPL2, IFNG
12interferon gamma459.4TNF, IL4, IFNG
13bleomycin45 1110.3CCL2, TIMP1, IL5, IL4, MMP9
14budesonide45 50 1111.3TNF, IL4, IL5, IFNG
15polymyxin b459.2IFNG, CCL2, IL4, TNF
16parthenolide45 210.2IFNG, TNF, MMP9, CCL2
17fluticasone propionate45 50 60 1112.2IFNG, MMP9, IL4, IL5, TNF
18poly(i-c)459.2TNF, IFNG, IL4, IL5
19ribavirin45 50 1111.2IL4, HLA-B, IFNG, TIMP1, MMP9
20il-12459.2IL4, IL5, TNF, IFNG, CCL2
21tarc459.1TNF, IL5, IL4, IFNG, CCL2
22polyinosinic-polycytidylic acid459.1IL5, HLA-B, IL4, TNF, IFNG
23cyclosporin a45 29 6011.0IFNG, IL1RAPL2, HLA-B, TNFRSF1B
24dexamethasone45 50 29 1112.0TNFRSF1B, TIMP1, IL5, IL1RAPL2, MMP9
25fmlp459.0PRTN3, IL5, TNFRSF1B, IL1RAPL2
26methylcellulose459.0IFNG, IL4, TIMP1, IL5
27imiquimod45 29 60 1111.9IFNG, IL1RAPL2, IL5, TNF
28curcumin458.8MMP9, TNF, TNFRSF1B, CCL2, TIMP1
29etanercept45 50 1110.7IL1RAPL2, TNF, TIMP1, IFNG, TNFRSF1B
30ly294002458.6IL5, MMP9, TNF, TNFRSF1B, CCL2, TIMP1
31leukotriene b445 60 2410.6IL1RAPL2, MMP9, CCL2, TNF, IL5
32herbimycin a45 609.6TIMP1, CCL2, IFNG, TNF, IL5, MMP9
33paraffin458.6TIMP1, MMP9, IL5, IL4, HLA-B, CCL2
34sb 20358045 609.6TIMP1, CCL2, IFNG, TNF, IL4, MMP9
35neopterin458.6IL1RAPL2, TNF, TNFRSF1B, IFNG, IL4
36rantes458.5TNF, IL1RAPL2, IL4, HLA-B, IFNG
37ionomycin458.4IL5, IFNG, TNF, PRTN3, IL4
38tgf beta1458.4TIMP1, IL1RAPL2, MMP9, CCL2, TNF
39methotrexate45 50 1110.4TIMP1, TNF, TNFRSF1B, MMP9, IL1RAPL2, IL5
40genistein45 29 60 2 11 2413.3CCL2, TIMP1, IL5, IFNG, TNF, PRTN3
41simvastatin45 50 60 29 11 2413.2TNF, MMP9, IL1RAPL2, IL4, CCL2, IFNG
42fibrinogen458.1MMP9, TNFRSF1B, TNF, HLA-B, IL1RAPL2, CCL2
43adenylate458.1TNFRSF1B, TIMP1, MMP9, IL1RAPL2, IL4, IL5
44il 10458.1IL1RAPL2, IL4, CCL2, IFNG, TNFRSF1B, TNF
45histamine45 29 2410.0IL5, IL4, CCL2, IL1RAPL2, TNF, IFNG
46infliximab45 50 119.9TIMP1, IFNG, TNFRSF1B, TNF, PRTN3, IL1RAPL2
47actinomycin d457.7MMP9, IL4, TNF, TNFRSF1B, CCL2, TIMP1
48vegf457.5MMP9, IL1RAPL2, IL4, IL5, TNF, TNFRSF1B
49serine457.2MMP9, IL1RAPL2, PRTN3, TNF, TNFRSF1B, HLA-B
50retinoic acid45 248.2IFNG, TIMP1, MMP9, TNF, HLA-B, PRTN3

GO Terms for genes affiliated with Scleritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CCL2, IFNG, TNFRSF1B, TNF, IL5, MMP9
2extracellular spaceGO:0056158.1MMP9, IL4, IL5, TNF, IFNG, CCL2

Biological processes related to Scleritis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:07180310.0TNF, IL5
2positive regulation of isotype switching to IgG isotypesGO:04830410.0IFNG, IL4
3positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, IFNG
4positive regulation of vitamin D biosynthetic processGO:0605579.9IFNG, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9TNF, IFNG
6cellular response to lipopolysaccharideGO:0712229.7TNFRSF1B, IFNG, CCL2
7positive regulation of synaptic transmissionGO:0508069.7TNF, CCL2
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, TNFRSF1B, IFNG
9positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
10positive regulation of chemokine biosynthetic processGO:0450809.6IL4, TNF, IFNG
11positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6TNF, IL5, IL4
12humoral immune responseGO:0069599.6TNF, IFNG, CCL2
13negative regulation of growth of symbiont in hostGO:0441309.5IFNG, TNF
14defense response to protozoanGO:0428329.5IL4, IFNG
15cytokine-mediated signaling pathwayGO:0192219.4CCL2, IFNG, HLA-B, IL5
16immune responseGO:0069559.3TNFRSF1B, HLA-B, IL5, IL4
17inflammatory responseGO:0069549.3IL5, TNF, TNFRSF1B, CCL2
18response to drugGO:0424939.2CCL2, IFNG, TNF, IL4

Molecular functions related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL5, TNF, IFNG

Products for genes affiliated with Scleritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Scleritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet