MCID: SCL015
MIFTS: 59

Scleritis malady

Eye diseases category
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Summaries for Scleritis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

MalaCards: Scleritis, also known as scleritis, unspecified, is related to arthritis and uveitis. An important gene associated with Scleritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug medrysone and the compounds tranilast and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are liver/biliary system and craniofacial.

Aliases & Classifications for Scleritis

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

scleritis 8 10 62
scleritis, unspecified 8
unspecified scleritis 8


External Ids:

Disease Ontology8 DOID:13452
MeSH35 D015423
ICD9CM27 379.00
ICD1025 H15.0

Related Diseases for Scleritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.7TNF, TIMP1
2uveitis30.6TNF, CCL2, IFNG, IL4
3vasculitis30.3CCL2, TNF, PRTN3, IL1RAPL2
4rheumatoid arthritis30.2IL1RAPL2, IFNG, CCL2, PRTN3, MMP9, IL4
5melanoma30.2TNF, IFNG, PRTN3, MMP9, TIMP1, IL4
6hepatitis c30.1IL1RAPL2, PRTN3, IFNG
7pneumonia30.1TNF, CCL2, IL5, IL1RAPL2
8connective tissue disease30.1PRTN3, CCL2, IL4, TNF
9sarcoidosis30.0CCL2, IFNG, TNF, IL1RAPL2
10tuberculosis30.0IL4, TNF, IL1RAPL2, IFNG
11blau syndrome29.9TNF
12allergic conjunctivitis29.8IL5, IL4
13psoriatic arthritis29.8TNF, IL1RAPL2
14ankylosing spondylitis29.8PRTN3, IL1RAPL2, TNF
15ulcerative colitis29.8TNF, PRTN3
16lepromatous leprosy29.8IFNG, IL4
17kawasaki disease29.8TIMP1, CCL2, MMP9
18toxic shock syndrome29.7IFNG, TNF
19vascular disease29.7CCL2, PRTN3, MMP9
20graft versus host disease29.6IFNG, IL4, IL1RAPL2, TNF
21periodontitis29.6TIMP1, IL1RAPL2, CCL2, TNF, MMP9
22leukemia29.6IFNG, IL4, IL1RAPL2, PRTN3, TNF
23inflammatory bowel disease29.5IL1RAPL2, IL4, IFNG, CCL2, PRTN3, TNF
24psoriasis29.5IFNG, IL5, IL4, IL1RAPL2, TNF, CCL2
25multiple sclerosis29.4IL5, IL1RAPL2, IFNG, CCL2, MMP9, TIMP1
26posterior scleritis10.8
27anterior scleritis10.6
28choroiditis10.5
29keratitis10.5
30retinitis10.4
31pterygium10.4
32glaucoma10.3
33wegener's granulomatosis10.3
34retinal detachment10.3
35strabismus10.3
36relapsing polychondritis10.3
37brawny scleritis10.3
38cataract10.2
39endophthalmitis10.2
40myositis10.2
41cryoglobulinemia10.1
42cogan's syndrome10.1
43necrobiotic xanthogranuloma10.1
44eosinophilic fasciitis10.1IL5
45kimura disease10.1IL5
46eosinophilia-myalgia syndrome10.1IL5
47keratoconjunctivitis10.1IL5
48strongyloidiasis10.1IL5
49pulpitis10.1TIMP1
50angiostrongyliasis10.1MMP9

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to scleritis

Symptoms for Scleritis

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Drugs & Therapeutics for Scleritis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Scleritis

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Scleritis

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Anatomical Context for Scleritis

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33MalaCards
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MalaCards organs/tissues related to Scleritis:

33
Eye, Thyroid, Testes, Bone, Lung, Breast, T cells, Endothelial, Bone marrow

Animal Models for Scleritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Scleritis:

37 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4IL5, CCL2, TNF, IFNG, IL4
2MP:00053828.2IFNG, CCL2, TNF, IL4
3MP:00053918.2MMP9, IFNG, IL4, TNF, CCL2
4MP:00053908.2MMP9, CCL2, IL4, TNF, IFNG
5MP:00020068.1MMP9, TNF, TIMP1, IL5, IFNG, CCL2
6MP:00107718.1CCL2, IFNG, MMP9, IL4, TNF
7MP:00053858.1TNF, IFNG, TIMP1, MMP9, CCL2
8MP:00053888.0TIMP1, IL5, IL4, IFNG, MMP9, TNF
9MP:00053818.0IL5, IL4, IFNG, CCL2, MMP9, TNF
10MP:00107687.7IL4, IFNG, MMP9, TIMP1, TNF, CCL2
11MP:00053897.7TIMP1, IL4, IFNG, CCL2, MMP9, TNF
12MP:00053787.6TNF, CCL2, IL5, IL4, IFNG, MMP9
13MP:00053767.6CCL2, MMP9, TIMP1, TNF, IFNG, IL4
14MP:00053977.2PRTN3, IL5, IL4, IFNG, CCL2, TIMP1
15MP:00053877.2TIMP1, PRTN3, MMP9, TNF, IL5, IL4

Publications for Scleritis

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52PubMed
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Articles related to Scleritis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Infectious Pseudomonas scleritis after strabismus surgery. (23871294)
2013
2
Cytomegalovirus-related Scleritis. (23876078)
2013
3
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. (22395202)
2013
4
Necrobiotic xanthogranuloma associated with necrotizing scleritis. (22814320)
2012
5
Scleritis therapy. (22015381)
2012
6
Scleritis--Wegener's granulomatosis. (23256431)
2012
7
Necrotizing scleritis in a patient positive for both c- and p-ANCA without underlying systemic vasculitis. (21792741)
2011
8
Interferon-gamma release assay in tuberculous scleritis. (21402999)
2011
9
Necrotizing nocardial scleritis successfully treated with surgical debridement and topical polyvinyl alcohol iodine and antibiotics. (21689016)
2011
10
Aspergillus fumigatus scleritis associated with monoclonal gammopathy of undetermined significance. (20532146)
2010
11
Successful treatment of severe nodular scleritis with adalimumab. (20155432)
2010
12
Infectious scleritis and surgical induced necrotizing scleritis. (19521437)
2010
13
An update on the cause and treatment of scleritis. (20842032)
2010
14
A case of necrotizing scleritis resulting from Pseudomonas aeruginosa. (19724201)
2009
15
Infliximab for the treatment of active scleritis. (19506593)
2009
16
Scleritis and systemic disease association in a community-based referral practice. (19837380)
2009
17
Inadvertent subretinal triamcinolone injection in a case of recurrent scleritis. (19610249)
2009
18
Surgically induced necrotising scleritis following three-port pars plana vitrectomy without scleral buckling: a series of three cases. (17304259)
2008
19
Nodular scleritis following alendronate therapy. (18569796)
2008
20
Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess. (18833414)
2008
21
Pseudomonas scleritis resistant to fourth-generation fluoroquinolones in a patient without prior trauma or surgery. (18569805)
2008
22
HIV-seropositive patient with Sweet's syndrome and nodular scleritis, showing dramatic response after adding dapsone to systemic corticosteroid therapy. (18717866)
2008
23
Comment on 'smoking delays the response to treatment in episcleritis and scleritis'. (16470220)
2006
24
Necrotizing scleritis due to varicella zoster infection: a case report. (17056468)
2006
25
Giant nodular posterior scleritis simulating choroidal melanoma. (16770031)
2006
26
Necrobiotic xanthogranuloma with posterior scleritis. (16682604)
2006
27
Bilateral surgically induced necrotising scleritis with secondary superinfection. (15615764)
2005
28
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. (15958765)
2005
29
Anterior scleritis, scleral thinning, and intraocular pressure measurement. (16321890)
2005
30
Evaluation of patients with scleritis for systemic disease. (15019326)
2004
31
Necrotizing scleritis after intraocular surgery associated with the use of polyester nonabsorbable sutures. (14522309)
2003
32
Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis. (14533032)
2003
33
Early manifestation of vogt-koyanagi-harada disease as unilateral posterior scleritis. (12457922)
2002
34
Self-inflicted anterior scleritis. (11150288)
2001
35
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
36
Cilioretinal artery occlusion in posterior scleritis. (10872939)
2000
37
Posterior scleritis: clinical profile and imaging characteristics. (10218301)
1998
38
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
39
Scleritis after glaucoma filtering surgery with mitomycin C. (9097808)
1995
40
Scleritis associated with coxsackle B type 5 infection. (7958049)
1994
41
Posterior scleritis as a fundus mass. (8183510)
1994
42
Clinical course of scleritis induced by cataract surgery: a case report. (7927636)
1994
43
Posterior scleritis: ultrasound and clinical findings. (8343917)
1993
44
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
45
Scleritis and Wegener's granulomatosis in children. (1882959)
1991
46
Acute scleritis in porphyria cutanea tarda. (2330942)
1990
47
Clinical manifestations of brawny scleritis. (434079)
1979
48
Clinical manifestations of brawny scleritis. (677204)
1978
49
Rheumatoid scleritis producing exophthalmos. (1131332)
1975
50
Scleritis and aortic incompetence. Two manifestations of connective tissue disease. (4394498)
1970

Variations for Scleritis

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Expression for genes affiliated with Scleritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for genes affiliated with Scleritis

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Sources:
50PathCards, 60Thomson Reuters, 54R&D Systems, 38NCBI BioSystems Database, 5Cell Signaling Technology, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Scleritis according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TIMP1, CCL2
29.7IL4, IL5
39.6CCL2, MMP9
49.6CCL2, MMP9
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5IFNG, IL4
69.5TNF, CCL2
79.4MMP9, TNF
8
Show member pathways
9.3CCL2, TIMP1, IL4
9
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.3TNF, IFNG
10
Show member pathways
9.3TNF, IFNG
119.3IFNG, TNF
129.3TNF, IFNG
139.3IFNG, TNF
14
Show member pathways
IL27-mediated signaling events38
9.3TNF, IFNG
15
Show member pathways
9.3TNF, IFNG
169.3IFNG, TNF
179.2IFNG, IL4, IL5
18
Show member pathways
Type III interferon signaling38
9.2IL4, IFNG, IL5
199.2IL4, IL5, IFNG
209.2IL5, IFNG, IL4
219.1IL4, TNF, IL5
22
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.1IL4, IL5, TNF
23
Show member pathways
9.1MMP9, TIMP1, TNF
24
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0TNF, CCL2, MMP9
259.0TNF, CCL2, MMP9
26
Show member pathways
thioredoxin pathway38
9.0IFNG, CCL2, TNF
279.0TNF, IFNG, CCL2
289.0CCL2, TNF, IFNG
299.0TNF, CCL2, IFNG
30
Show member pathways
Immune response CD16 signaling in NK cells60
8.9IL4, IFNG, TNF
31
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IL4, IFNG, TNF
32
Show member pathways
8.9TNF, IL4, IFNG
338.9IFNG, TNF, MMP9
34
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6TIMP1, TNF, IFNG, CCL2
35
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.6IL4, IL5, IFNG, TNF
36
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.6IL4, IFNG, TNF, IL5
378.6IFNG, IL4, IL5, TNF
38
Show member pathways
8.6TNF, IFNG, IL5, IL4
398.6IL5, IL4, IFNG, TNF
40
Show member pathways
8.6IL5, IL4, IFNG, TNF
41
Show member pathways
8.5IL4, TNF, CCL2, IFNG
42
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5TNF, IFNG, CCL2, MMP9
43
Show member pathways
8.4IL5, IL4, CCL2, TNF, TIMP1
44
Show member pathways
8.4IL5, IL4, CCL2, TIMP1, TNF
45
Show member pathways
8.4IL5, TIMP1, TNF, IL4, CCL2
468.1TNF, MMP9, CCL2, IL4, IFNG
47
Show member pathways
7.9TNF, CCL2, IFNG, IL4, IL5, TIMP1
48
Show member pathways
7.9IFNG, TNF, TIMP1, IL5, IL4, CCL2

Compounds for genes affiliated with Scleritis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Scleritis according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1tranilast459.2TIMP1, IFNG, MMP9
2methylcellulose459.1IL4, TIMP1, IL5, IFNG
3interferon gamma459.1IFNG, IL4, TNF
4bleomycin45 1110.0TIMP1, IL5, IL4, CCL2, MMP9
5ribavirin45 51 1110.9TIMP1, IL4, IFNG, MMP9
6budesonide45 51 1110.9IL4, IFNG, IL5, TNF
7polymyxin b458.9IL4, TNF, IFNG, CCL2
8polyinosinic-polycytidylic acid458.9TNF, IL5, IL4, IFNG
9rolipram45 61 2910.9IL4, IFNG, TNF, IL5
10poly(i-c)458.9IFNG, IL5, IL4, TNF
11parthenolide45 39.8IFNG, CCL2, TNF, MMP9
12amphotericin b458.8IL1RAPL2, IL5, IL4, IFNG
13il-12458.7IL4, CCL2, TNF, IL5, IFNG
14ccl345 299.7IFNG, CCL2, MMP9, TNF
15gm-csf45 299.6CCL2, TNF, IL4, IL5, IFNG
16tarc458.6IFNG, CCL2, TNF, IL5, IL4
17fluticasone propionate45 51 61 1111.6IL4, IFNG, MMP9, IL5, TNF
18imiquimod45 61 29 1111.6IL5, IFNG, TNF, IL1RAPL2
19tacrolimus45 51 1110.5IL5, IL4, IFNG, TIMP1, TNF
20pdtc458.5CCL2, MMP9, TNF, IFNG, IL4
21etanercept45 51 1110.4IFNG, TNF, TIMP1, IL1RAPL2
22ionomycin458.4IFNG, TNF, PRTN3, IL4, IL5
23ly294002458.3IL5, TNF, MMP9, CCL2, TIMP1, IL4
24leukotriene b445 61 2410.3CCL2, IL1RAPL2, MMP9, IL5, TNF
2515-deoxy-delta-12,14-prostaglandin j2458.2IL4, IFNG, TNF, CCL2
26pentoxifylline45 119.2IL1RAPL2, IL4, TNF, IFNG
27butyrate458.2TNF, TIMP1, MMP9, IL5, IFNG
28tgf beta1458.2TNF, TIMP1, MMP9, CCL2, IL1RAPL2
29n acetylcysteine458.2IL4, CCL2, MMP9, TIMP1, TNF
30methotrexate51 45 1110.1TNF, IL5, IL1RAPL2, MMP9, TIMP1
31fmlp458.1IL5, PRTN3, TNF, IL1RAPL2, CCL2
32neopterin458.1IL4, IFNG, TNF, IL1RAPL2
33herbimycin a45 618.9TNF, MMP9, TIMP1, CCL2, IL5, IL4
34rosiglitazone29 45 51 24 1111.9TIMP1, IL1RAPL2, IL4, TNF, MMP9, CCL2
35sb 20358045 618.9TNF, IL5, MMP9, IL4, IFNG, CCL2
36il 10457.9IL5, IFNG, CCL2, TNF, IL1RAPL2, IL4
37indomethacin45 29 61 1110.8IL5, IL4, IFNG, TIMP1, TNF, IL1RAPL2
38ivig457.8MMP9, IFNG, IL5, IL4, IL1RAPL2, TNF
39genistein45 29 61 3 24 1112.7TNF, IL5, MMP9, TIMP1, IFNG, PRTN3
40simvastatin45 51 61 29 24 1112.7TNF, MMP9, CCL2, IFNG, IL4, IL1RAPL2
41infliximab45 51 119.7IL1RAPL2, IL4, IFNG, PRTN3, TIMP1, TNF
42histamine45 29 249.5TNF, IL4, IFNG, CCL2, TIMP1, IL5
43cyclosporin a45 29 619.4IFNG, IL1RAPL2, TNF, TIMP1, MMP9, IL4
44actinomycin d457.3IL1RAPL2, MMP9, IL4, IFNG, TNF, TIMP1
45retinoic acid45 248.2TNF, PRTN3, TIMP1, MMP9, IL5, IL1RAPL2
46rantes457.1TNF, IL5, IL1RAPL2, TIMP1, MMP9, CCL2
47pge2457.0IL1RAPL2, IL5, IL4, CCL2, IFNG, MMP9
48dexamethasone45 51 29 1110.0IL1RAPL2, IFNG, MMP9, IL4, IL5, CCL2
49vegf457.0IL1RAPL2, IFNG, TIMP1, IL5, IL4, CCL2
50cycloheximide456.5TNF, MMP9, PRTN3, IFNG, CCL2, IL4

GO Terms for genes affiliated with Scleritis

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Sources:
16Gene Ontology
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Cellular components related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL4, IFNG, TNF
2extracellular spaceGO:0056157.7IL4, TNF, MMP9, CCL2, IFNG, IL5
3extracellular regionGO:0055767.5IL5, TNF, TIMP1, MMP9, CCL2, IFNG

Biological processes related to Scleritis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.9IL5, IL4
2positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
3positive regulation of podosome assemblyGO:0718039.9IL5, TNF
4positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
5defense response to protozoanGO:0428329.8IFNG, IL4
6positive regulation of synaptic transmissionGO:0508069.8CCL2, TNF
7lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, CCL2
8response to activityGO:0148239.7CCL2, TNF
9positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
10positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
11protein kinase B signalingGO:0434919.7TNF, CCL2
12cellular response to organic cyclic compoundGO:0714079.7TNF, CCL2
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
14neutrophil chemotaxisGO:0305939.6CCL2, IFNG
15negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF
16positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
17protein import into nucleus, translocationGO:0000609.6IFNG, TNF
18positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
19extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
20response to mechanical stimulusGO:0096129.5TNF, CCL2
21positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL5, IL4, TNF
22positive regulation of T cell proliferationGO:0421029.4IL4, IFNG
23response to cytokineGO:0340979.4IL4, TIMP1
24humoral immune responseGO:0069599.3TNF, CCL2, IFNG
25positive regulation of chemokine biosynthetic processGO:0450809.3IL4, IFNG, TNF
26inflammatory responseGO:0069549.3CCL2, IL5, TNF
27extracellular matrix organizationGO:0301989.1MMP9, TNF, TIMP1
28response to drugGO:0424938.9IFNG, CCL2, TNF, IL4
29cytokine-mediated signaling pathwayGO:0192218.8IL5, IL1RAPL2, IFNG, CCL2

Molecular functions related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL5, IL4, IFNG, TNF

Products for genes affiliated with Scleritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Scleritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet