MCID: SCL015
MIFTS: 50

Scleritis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Scleritis

MalaCards integrated aliases for Scleritis:

Name: Scleritis 12 49 41 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13452
ICD10 32 H15.0 H15.00
ICD9CM 34 379.00
MeSH 41 D015423
NCIt 46 C119046
UMLS 69 C0036416

Summaries for Scleritis

MalaCards based summary : Scleritis is related to uveitis and cellulitis. An important gene associated with Scleritis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and thyroid, and related phenotypes are immune system and respiratory system

Wikipedia : 72 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

Related Diseases for Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.2 CCL2 IL4 TNF
2 cellulitis 30.2 IL5 TNF
3 pyoderma gangrenosum 30.1 ITGB2 TNF
4 pyoderma 30.1 ITGB2 TNF
5 vasculitis 29.9 CCL2 SELE TNF
6 stromal keratitis 29.7 CCL2 TNF
7 arthritis 29.7 CCL2 MMP9 TNF
8 pneumonia 29.7 CCL2 IL5 TNF
9 wegener granulomatosis 29.7 ITGB2 SELE TNF
10 chronic conjunctivitis 29.5 IL4 IL5
11 rheumatoid arthritis 29.4 CCL2 IL4 ITGB2 TNF
12 allergic conjunctivitis 29.3 IL4 IL5
13 autoimmune disease 29.3 IL4 IL5 TNF
14 brucellosis 29.2 IL4 TNF
15 neuritis 29.2 CCL2 IL4 TNF
16 leprosy 3 28.9 IL4 TNF
17 takayasu arteritis 28.9 MMP9 SELE TNF
18 vascular disease 28.7 CCL2 MMP9 SELE
19 systemic lupus erythematosus 28.4 CCL2 IL4 SELE TNF
20 periodontitis 28.2 CCL2 IL4 MMP9 TNF
21 psoriasis 28.2 CCL2 IL22 IL4 SELE TNF
22 multiple sclerosis 27.8 CCL2 IL4 IL5 MMP9 TNF
23 inflammatory bowel disease 27.7 CCL2 IL22 IL4 IL5 SELE TNF
24 posterior scleritis 12.1
25 anterior scleritis 12.1
26 brawny scleritis 12.1
27 scleroperikeratitis 11.1
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 TNF
29 cardiac sarcoidosis 10.4 IL5 TNF
30 anthracosis 10.4 CCL2 TNF
31 stachybotrys chartarum 10.4 CCL2 TNF
32 ischemic heart disease 10.3 CCL2 TNF
33 pleural tuberculosis 10.3 CCL2 TNF
34 retinitis pigmentosa 60 10.3 SELE TNF
35 actinic prurigo 10.3 SELE TNF
36 churg-strauss syndrome 10.3 IL5 TNF
37 rheumatoid vasculitis 10.3 SELE TNF
38 granulocytopenia 10.3 ITGB2 TNF
39 radiculopathy 10.3 CCL2 IL5
40 viral encephalitis 10.3 CCL2 TNF
41 endometritis 10.3 SELE TNF
42 tropical endomyocardial fibrosis 10.3 IL4 TNF
43 cytomegalovirus infection 10.3 SELE TNF
44 tungiasis 10.3 IL4 TNF
45 endomyocardial fibrosis 10.3 IL4 TNF
46 localized scleroderma 10.3 SELE TNF
47 dengue shock syndrome 10.2 CCL2 TNF
48 plasmodium vivax malaria 10.2 SELE TNF
49 critical illness polyneuropathy 10.2 SELE TNF
50 pleurisy 10.2 CCL2 TNF

Comorbidity relations with Scleritis via Phenotypic Disease Network (PDN):


Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to Scleritis

Symptoms & Phenotypes for Scleritis

MGI Mouse Phenotypes related to Scleritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 CCL2 IL4 IL5 ITGB2 MMP9 SELE
2 respiratory system MP:0005388 9.35 TNF IL4 IL5 MMP9 SELE
3 vision/eye MP:0005391 9.02 TNF IL4 ITGB2 MMP9 SELE

Drugs & Therapeutics for Scleritis

Drugs for Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 4
2 beta-endorphin Phase 4
3 Hormone Antagonists Phase 4,Phase 2,Phase 1
4 Hormones Phase 4,Phase 2,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4
7
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
8
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
9
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
10
Infliximab Approved Phase 2,Phase 1 170277-31-3
11
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
12
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
13
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
14
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
15
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
16
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
17 Autonomic Agents Phase 1, Phase 2
18 Nasal Decongestants Phase 1, Phase 2
19 Ophthalmic Solutions Phase 1, Phase 2
20 Peripheral Nervous System Agents Phase 1, Phase 2
21 Pharmaceutical Solutions Phase 1, Phase 2
22 Respiratory System Agents Phase 1, Phase 2
23 Tetrahydrozoline Phase 1, Phase 2
24 Vasoconstrictor Agents Phase 1, Phase 2
25 Anti-Bacterial Agents Phase 1, Phase 2
26 Antibiotics, Antitubercular Phase 1, Phase 2
27 Anti-Infective Agents Phase 1, Phase 2
28 Immunosuppressive Agents Phase 1, Phase 2
29 Antirheumatic Agents Phase 1, Phase 2
30 Antifungal Agents Phase 1, Phase 2
31 Anti-Inflammatory Agents Phase 2,Phase 1
32 Antineoplastic Agents, Hormonal Phase 2,Phase 1
33 Dermatologic Agents Phase 2,Phase 1
34 Gastrointestinal Agents Phase 2,Phase 1
35 glucocorticoids Phase 2,Phase 1
36 Alkylating Agents Phase 2
37
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
38 Antiemetics Phase 1
39 BB 1101 Phase 1
40 Dexamethasone 21-phosphate Phase 1
41 Dexamethasone acetate Phase 1 1177-87-3
42 HIV Protease Inhibitors Phase 1
43
protease inhibitors Phase 1
44
Adalimumab Approved 331731-18-1 16219006
45
Azathioprine Approved 446-86-6 2265
46
Etanercept Approved, Investigational 185243-69-0
47
Methylprednisolone Approved, Vet_approved 83-43-2 6741
48
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
49
Mycophenolic acid Approved 24280-93-1 446541
50
Prednisolone Approved, Vet_approved 50-24-8 5755

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2 Seawater eyedrops
3 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
4 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
5 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
7 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
8 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
9 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
10 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
11 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567
12 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823
13 Human Samples and Data Repository Completed NCT00539370
14 Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Completed NCT00116090
15 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
16 Influencing Factors in Uveitis Completed NCT00827086
17 Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome Recruiting NCT02715323
18 Uveitis/Intraocular Inflammatory Disease Biobank (iBank) Recruiting NCT02656381
19 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Enrolling by invitation NCT00357071

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: scleritis

Genetic Tests for Scleritis

Anatomical Context for Scleritis

MalaCards organs/tissues related to Scleritis:

38
Eye, Neutrophil, Thyroid, Bone, T Cells, Testes, Endothelial

Publications for Scleritis

Articles related to Scleritis:

(show top 50) (show all 643)
# Title Authors Year
1
Posterior scleritis follow-up by Swept-Source optical coherence tomography. ( 29169639 )
2018
2
Clinical Profile of Scleritis in Children. ( 29370565 )
2018
3
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
4
Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. ( 29433463 )
2018
5
Pulmonary nodules and nodular scleritis in a teenager with superficial granulomatous pyoderma gangrenosum. ( 29243307 )
2018
6
Paradoxical Nodular Scleritis during Tocilizumab Therapy: A Case Report. ( 29093079 )
2017
7
Interventions and Outcomes in Patients with Infectious Pseudomonas scleritis: A 10-Year Perspective. ( 29040032 )
2017
8
Severe Idiopathic Posterior Scleritis in a Patient with HIV. ( 28147399 )
2017
9
Anterior scleritis following intravitreal injections in a patient with rheumatoid arthritis: A case report. ( 29382031 )
2017
10
Hypertrophic Pachymeningitis Accompanying Scleritis. ( 28794383 )
2017
11
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
12
Anterior Scleritis Associated with Pemphigus Vulgaris. ( 29095065 )
2017
13
Occult Fungal Scleritis. ( 28275602 )
2017
14
Ocular Pharmacology for Scleritis: Review of Treatment and a Practical Perspective. ( 28355124 )
2017
15
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
16
When an Easy Thing Goes Wrong: Foreign Body Induced Granuloma-Associated Scleritis Following Pterygium Surgery. ( 28512421 )
2017
17
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. ( 28844204 )
2017
18
Conjunctival Necrosis Masquerading as Necrotizing Scleritis. ( 28910555 )
2017
19
Posterior Scleritis with Choroidal Effusion Secondary to Herpes Zoster Ophthalmicus. ( 28981391 )
2017
20
Pseudomonas Scleritis following Pterygium Excision. ( 28924436 )
2017
21
Bilateral Posterior Scleritis Associated with Giant Cell Arteritis: A Case Report. ( 28914559 )
2017
22
An OCT Study of Anterior Nodular Episcleritis and Scleritis. ( 28348907 )
2017
23
Sweet Syndrome Associated with Bilateral Nodular Scleritis. ( 29282197 )
2017
24
Necrobiotic xanthogranuloma scleritis in a case of granulomatosis with polyangiitis (Wegener's granulomatosis). ( 29042820 )
2017
25
Scleritis Associated with SAPHO Syndrome: A Case Report. ( 28060551 )
2017
26
Anakinra in the Treatment of Patients with Refractory Scleritis: A Pilot Study. ( 28537473 )
2017
27
Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma. ( 28394239 )
2017
28
Endophthalmitis associated with Purpureocillium lilacinum during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. ( 28429128 )
2017
29
IgG4-related disease as an emerging cause of scleritis. ( 28229544 )
2017
30
Rituximab Induction and Maintenance Treatment in Patients with Scleritis and Granulomatosis with Polyangiitis (Wegener's). ( 28628344 )
2017
31
Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye. ( 28769139 )
2017
32
Indocyanine green angiography in anterior scleritis. ( 28886929 )
2017
33
Successful treatment with tocilizumab for refractory scleritis associated with relapsing polychondritis. ( 28120637 )
2017
34
Invasive Ocular Surface Squamous Neoplasia Masquerading as Nodular Scleritis. ( 27262144 )
2016
35
Patterns of Uveitis and Scleritis in Nepal: A Tertiary Referral Center Study. ( 27191731 )
2016
36
Ocular toxocariasis presenting as bilateral scleritis with suspect retinal granuloma in the nerve fiber layer: a case report. ( 27538451 )
2016
37
Multifocal Surgically Induced Necrotizing Scleritis Following Strabismus Surgery: A Case Report. ( 27485819 )
2016
38
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
39
Scleritis. ( 26872551 )
2016
40
Trigeminal autonomic cephalgia caused by recurrent posterior scleritis. ( 27495133 )
2016
41
Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process. ( 27298747 )
2016
42
Nodular scleritis as a presenting feature of Takayasu's arteritis. ( 27221684 )
2016
43
Mycobacterium abscessus scleritis after a Baerveldt glaucoma implant. ( 27552708 )
2016
44
Rituximab in the Treatment of Refractory Noninfectious Scleritis. ( 27138731 )
2016
45
Trabecular Micro-Bypass Stent Use in Necrotizing Scleritis. ( 27977475 )
2016
46
Rituximab in the Treatment of Refractory Noninfectious Scleritis. ( 26766304 )
2016
47
Gevokizumab in the treatment of autoimmune, non-necrotizing, anterior scleritis: Results of a phase I/II clinical trial. ( 27663070 )
2016
48
Scleritis with Devastating Consequences. ( 27772649 )
2016
49
Diagnosis and management of non-infectious immune-mediated scleritis: current status and future prospects. ( 27055583 )
2016
50
Local treatment for scleritis secondary to Wiskott-Aldrich syndrome. ( 26951873 )
2016

Variations for Scleritis

Expression for Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for Scleritis

Pathways related to Scleritis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCL2 IL22 IL4 IL5 ITGB2 MMP9
2
Show member pathways
13.62 CCL2 IL22 IL4 IL5 ITGB2 TNF
3
Show member pathways
13.35 CCL2 IL22 IL4 IL5 ITGB2 TNF
4
Show member pathways
13.21 CCL2 IL22 IL4 IL5 ITGB2 TNF
5
Show member pathways
13.13 CCL2 IL22 IL4 IL5 ITGB2 MMP9
6
Show member pathways
13.12 CCL2 IL22 IL4 IL5 TNF
7
Show member pathways
12.74 CCL2 MMP9 SELE TNF
8
Show member pathways
12.69 IL22 IL4 IL5 ITGB2 TNF
9
Show member pathways
12.46 IL22 IL4 IL5 TNF
10 12.43 CCL2 IL4 ITGB2 TNF
11
Show member pathways
12.36 IL4 ITGB2 TNF
12
Show member pathways
12.29 IL4 IL5 TNF
13
Show member pathways
12.22 IL22 IL4 IL5
14
Show member pathways
12.2 CCL2 IL4 TNF
15
Show member pathways
12.12 IL4 ITGB2 TNF
16
Show member pathways
12.1 CCL2 IL4 IL5 MMP9 TNF
17
Show member pathways
12.04 IL4 IL5 TNF
18 11.97 CCL2 MMP9 SELE TNF
19 11.89 CCL2 IL4 MMP9 TNF
20 11.88 IL4 IL5 TNF
21 11.83 CCL2 MMP9 SELE TNF
22 11.8 CCL2 SELE TNF
23 11.79 IL4 IL5 TNF
24 11.75 CCL2 ITGB2 TNF
25 11.69 IL4 IL5 SELE
26
Show member pathways
11.66 IL4 IL5 TNF
27 11.66 IL22 IL4 IL5 TNF
28
Show member pathways
11.56 MMP9 SELE TNF
29 11.52 IL4 IL5 ITGB2 TNF
30 11.44 CCL2 IL4 TNF
31 11.42 ITGB2 MMP9 TNF
32 11.42 CCL2 ITGB2 TNF
33 11.41 CCL2 IL4 ITGB2 MMP9 TNF
34 11.37 IL4 IL5
35 11.29 MMP9 SELE
36 11.25 CCL2 ITGB2 SELE TNF
37 11.24 SELE TNF
38 11.22 CCL2 MMP9
39 11.21 IL4 IL5
40 11.19 CCL2 MMP9
41 11.19 IL4 IL5 TNF
42 11.1 IL4 IL5
43 11.08 CCL2 MMP9
44 10.96 IL22 IL4 IL5 TNF
45 10.95 CCL2 IL22 IL4 IL5 TNF
46 10.86 CCL2 TNF
47 10.82 CCL2 IL4 IL5 MMP9 TNF
48 10.81 CCL2 IL22 IL4 IL5 ITGB2 TNF
49 10.73 IL4 IL5

GO Terms for Scleritis

Cellular components related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL2 IL22 IL4 IL5 MMP9 TNF
2 extracellular space GO:0005615 9.17 CCL2 IL22 IL4 IL5 MMP9 SELE

Biological processes related to Scleritis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.71 CCL2 IL5 TNF
2 immune response GO:0006955 9.71 CCL2 IL4 IL5 TNF
3 extracellular matrix organization GO:0030198 9.65 ITGB2 MMP9 TNF
4 protein kinase B signaling GO:0043491 9.57 CCL2 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 ITGB2 TNF
6 positive regulation of B cell proliferation GO:0030890 9.55 IL4 IL5
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 CCL2 TNF
8 endodermal cell differentiation GO:0035987 9.51 ITGB2 MMP9
9 leukocyte cell-cell adhesion GO:0007159 9.49 ITGB2 SELE
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 MMP9 TNF
11 leukocyte migration GO:0050900 9.46 ITGB2 MMP9 SELE TNF
12 leukocyte tethering or rolling GO:0050901 9.43 SELE TNF
13 positive regulation of podosome assembly GO:0071803 9.37 IL5 TNF
14 regulation of receptor activity GO:0010469 9.35 CCL2 IL22 IL4 IL5 TNF
15 leukocyte migration involved in inflammatory response GO:0002523 9.32 ITGB2 SELE
16 cellular extravasation GO:0045123 9.26 ITGB2 TNF
17 inflammatory response GO:0006954 9.1 CCL2 IL22 IL5 ITGB2 SELE TNF

Molecular functions related to Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IL22 IL4 IL5 TNF

Sources for Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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