MCID: SCL015
MIFTS: 60

Scleritis malady

Eye diseases category

Summaries for Scleritis

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Wikipedia:64 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

MalaCards based summary: Scleritis, also known as scleritis, unspecified, is related to arthritis and blau syndrome. An important gene associated with Scleritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug medrysone and the compounds tranilast and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and thyroid, and related mouse phenotypes are liver/biliary system and craniofacial.

Aliases & Classifications for Scleritis

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Scleritis, Aliases & Descriptions:

Name: Scleritis 9 11 61
Scleritis, Unspecified 9 61
 
Unspecified Scleritis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:13452
ICD9CM28 379.00
MeSH34 D015423
ICD1026 H15.0

Related Diseases for Scleritis

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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TIMP1, TNF
2blau syndrome30.4TNF
3uveitis30.3IL4, IFNG, CCL2, TNF
4vasculitis30.2TNF, PRTN3, CCL2, IL1RAPL2
5allergic conjunctivitis30.2IL4, IL5
6psoriatic arthritis30.1IL1RAPL2, TNF
7hepatitis c30.1IL1RAPL2, IFNG, PRTN3
8pneumonia30.1TNF, CCL2, IL5, IL1RAPL2
9ankylosing spondylitis30.0TNF, PRTN3, IL1RAPL2
10connective tissue disease30.0IL4, CCL2, PRTN3, TNF
11ulcerative colitis29.9TNF, PRTN3
12lepromatous leprosy29.9IFNG, IL4
13sarcoidosis29.9TNF, CCL2, IFNG, IL1RAPL2
14kawasaki disease29.8TIMP1, MMP9, CCL2
15toxic shock syndrome29.8TNF, IFNG
16vascular disease29.8CCL2, PRTN3, MMP9
17tuberculosis29.7TNF, IFNG, IL4, IL1RAPL2
18melanoma29.4TNF, TIMP1, MMP9, PRTN3, IFNG, IL4
19graft versus host disease29.4IL1RAPL2, IL4, IFNG, TNF
20colitis29.4TNF, IFNG, IL4, IL1RAPL2
21leukemia29.3TNF, PRTN3, IFNG, IL4, IL1RAPL2
22periodontitis29.3TNF, TIMP1, MMP9, CCL2, IL1RAPL2
23rheumatoid arthritis29.1TNF, TIMP1, MMP9, PRTN3, CCL2, IFNG
24inflammatory bowel disease28.9TNF, PRTN3, CCL2, IFNG, IL4, IL1RAPL2
25systemic lupus erythematosus28.9TNF, PRTN3, CCL2, IFNG, IL4, IL1RAPL2
26psoriasis28.8TNF, CCL2, IFNG, IL4, IL5, IL1RAPL2
27multiple sclerosis28.2TNF, IL1RAPL2, IL5, IL4, IFNG, CCL2
28posterior scleritis10.8
29anterior scleritis10.6
30eosinophilic fasciitis10.5IL5
31kimura disease10.5IL5
32eosinophilia-myalgia syndrome10.5IL5
33keratoconjunctivitis10.5IL5
34strongyloidiasis10.5IL5
35choroiditis10.5
36keratitis10.5
37pulpitis10.5TIMP1
38retinitis10.5
39angiostrongyliasis10.4MMP9
40wegener's granulomatosis10.4
41sinusitis10.4IL5, PRTN3
42pterygium10.4
43churg-strauss syndrome10.3PRTN3, IL5
44aspergillosis10.3IFNG
45strabismus10.3
46retinal detachment10.3
47spondylarthropathy10.3TNF, IL1RAPL2
48bronchitis10.3PRTN3, IL5
49skin disease10.3MMP9
50egg allergy10.3IL4, IL5

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to scleritis

Symptoms for Scleritis

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Drugs & Therapeutics for Scleritis

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Drug clinical trials:

Search ClinicalTrials for Scleritis

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Scleritis

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Anatomical Context for Scleritis

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MalaCards organs/tissues related to Scleritis:

32
Eye, Neutrophil, Thyroid, Bone, Testes, T cells, Lung, Breast, Endothelial, Bone marrow

Animal Models for Scleritis or affiliated genes

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MGI Mouse Phenotypes related to Scleritis:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4TNF, CCL2, IFNG, IL4, IL5
2MP:00053828.2IL4, IFNG, CCL2, TNF
3MP:00053918.2IL4, IFNG, CCL2, MMP9, TNF
4MP:00053908.2TNF, MMP9, CCL2, IFNG, IL4
5MP:00020068.1TNF, TIMP1, MMP9, CCL2, IFNG, IL5
6MP:00107718.1IL4, IFNG, CCL2, MMP9, TNF
7MP:00053858.1TNF, TIMP1, MMP9, CCL2, IFNG
8MP:00053888.0TNF, TIMP1, MMP9, IFNG, IL4, IL5
9MP:00053818.0TNF, MMP9, CCL2, IFNG, IL4, IL5
10MP:00107687.7TIMP1, MMP9, CCL2, IFNG, IL4, TNF
11MP:00053897.7TNF, TIMP1, MMP9, CCL2, IFNG, IL4
12MP:00053787.6TNF, TIMP1, MMP9, CCL2, IFNG, IL4
13MP:00053767.6TNF, TIMP1, MMP9, CCL2, IFNG, IL4
14MP:00053977.2IL5, TNF, TIMP1, MMP9, PRTN3, CCL2
15MP:00053877.2TNF, TIMP1, MMP9, PRTN3, CCL2, IFNG

Publications for Scleritis

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Articles related to Scleritis:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Infectious Pseudomonas scleritis after strabismus surgery. (23871294)
2013
2
Cytomegalovirus-related Scleritis. (23876078)
2013
3
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. (22395202)
2013
4
Necrobiotic xanthogranuloma associated with necrotizing scleritis. (22814320)
2012
5
Posterior scleritis resembling acute retinal necrosis syndrome. (25390725)
2012
6
Scleritis therapy. (22015381)
2012
7
Scleritis--Wegener's granulomatosis. (23256431)
2012
8
Necrotizing scleritis in a patient positive for both c- and p-ANCA without underlying systemic vasculitis. (21792741)
2011
9
Interferon-gamma release assay in tuberculous scleritis. (21402999)
2011
10
Necrotizing nocardial scleritis successfully treated with surgical debridement and topical polyvinyl alcohol iodine and antibiotics. (21689016)
2011
11
Successful treatment of severe nodular scleritis with adalimumab. (20155432)
2010
12
Infectious scleritis and surgical induced necrotizing scleritis. (19521437)
2010
13
An update on the cause and treatment of scleritis. (20842032)
2010
14
A case of necrotizing scleritis resulting from Pseudomonas aeruginosa. (19724201)
2009
15
Infliximab for the treatment of active scleritis. (19506593)
2009
16
Scleritis and systemic disease association in a community-based referral practice. (19837380)
2009
17
Inadvertent subretinal triamcinolone injection in a case of recurrent scleritis. (19610249)
2009
18
Surgically induced necrotising scleritis following three-port pars plana vitrectomy without scleral buckling: a series of three cases. (17304259)
2008
19
Nodular scleritis following alendronate therapy. (18569796)
2008
20
Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess. (18833414)
2008
21
Pseudomonas scleritis resistant to fourth-generation fluoroquinolones in a patient without prior trauma or surgery. (18569805)
2008
22
HIV-seropositive patient with Sweet's syndrome and nodular scleritis, showing dramatic response after adding dapsone to systemic corticosteroid therapy. (18717866)
2008
23
Comment on 'smoking delays the response to treatment in episcleritis and scleritis'. (16470220)
2006
24
Necrotizing scleritis due to varicella zoster infection: a case report. (17056468)
2006
25
Giant nodular posterior scleritis simulating choroidal melanoma. (16770031)
2006
26
Bilateral surgically induced necrotising scleritis with secondary superinfection. (15615764)
2005
27
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. (15958765)
2005
28
Deep intramuscular methylprednisolone treatment of recurrent scleritis. (15804772)
2005
29
Anterior scleritis, scleral thinning, and intraocular pressure measurement. (16321890)
2005
30
Evaluation of patients with scleritis for systemic disease. (15019326)
2004
31
Necrotizing scleritis after intraocular surgery associated with the use of polyester nonabsorbable sutures. (14522309)
2003
32
Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis. (14533032)
2003
33
Early manifestation of vogt-koyanagi-harada disease as unilateral posterior scleritis. (12457922)
2002
34
Self-inflicted anterior scleritis. (11150288)
2001
35
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
36
Cilioretinal artery occlusion in posterior scleritis. (10872939)
2000
37
Posterior scleritis: clinical profile and imaging characteristics. (10218301)
1998
38
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
39
Scleritis after glaucoma filtering surgery with mitomycin C. (9097808)
1995
40
Scleritis associated with coxsackle B type 5 infection. (7958049)
1994
41
Posterior scleritis as a fundus mass. (8183510)
1994
42
Clinical course of scleritis induced by cataract surgery: a case report. (7927636)
1994
43
Posterior scleritis: ultrasound and clinical findings. (8343917)
1993
44
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
45
Scleritis and Wegener's granulomatosis in children. (1882959)
1991
46
Acute scleritis in porphyria cutanea tarda. (2330942)
1990
47
Clinical manifestations of brawny scleritis. (434079)
1979
48
Clinical manifestations of brawny scleritis. (677204)
1978
49
Rheumatoid scleritis producing exophthalmos. (1131332)
1975
50
Scleritis and aortic incompetence. Two manifestations of connective tissue disease. (4394498)
1970

Variations for Scleritis

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Expression for genes affiliated with Scleritis

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Expression patterns in normal tissues for genes affiliated with Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for genes affiliated with Scleritis

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Pathways related to Scleritis according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TIMP1, CCL2
29.7IL5, IL4
39.6CCL2, MMP9
49.6CCL2, MMP9
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.5IL4, IFNG
69.5CCL2, TNF
79.4TNF, MMP9
8
Show member pathways
9.3IL4, CCL2, TIMP1
9
Show member pathways
9.3IFNG, TNF
109.3TNF, IFNG
119.3IFNG, TNF
12
Show member pathways
IL27-mediated signaling events37
9.3IFNG, TNF
139.3IFNG, TNF
14
Show member pathways
9.3TNF, IFNG
15
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.3IFNG, TNF
169.3IFNG, TNF
179.2IL5, IL4, IFNG
189.2IL5, IL4, IFNG
199.2IL5, IL4, IFNG
20
Show member pathways
Type III interferon signaling37
9.2IL5, IL4, IFNG
219.1TNF, IL4, IL5
22
Show member pathways
Immune response BCR pathway59
Fc-epsilon receptor I signaling in mast cells37
9.1TNF, IL4, IL5
23
Show member pathways
9.1TNF, TIMP1, MMP9
249.0CCL2, MMP9, TNF
25
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0TNF, MMP9, CCL2
269.0IFNG, CCL2, TNF
279.0IFNG, CCL2, TNF
289.0IFNG, CCL2, TNF
29
Show member pathways
thioredoxin pathway37
9.0TNF, CCL2, IFNG
30
Show member pathways
Immune response CD16 signaling in NK cells59
8.9IL4, IFNG, TNF
31
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.9TNF, IFNG, IL4
32
Show member pathways
8.9TNF, IFNG, IL4
338.9TNF, MMP9, IFNG
34
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6TNF, TIMP1, CCL2, IFNG
35
Show member pathways
8.6TNF, IFNG, IL4, IL5
36
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.6IL5, IL4, IFNG, TNF
378.6TNF, IFNG, IL4, IL5
38
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.6TNF, IFNG, IL4, IL5
398.6TNF, IFNG, IL4, IL5
40
Show member pathways
8.6TNF, IFNG, IL4, IL5
41
Show member pathways
8.5TNF, CCL2, IFNG, IL4
42
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5TNF, MMP9, CCL2, IFNG
43
Show member pathways
8.4TNF, TIMP1, CCL2, IL4, IL5
44
Show member pathways
8.4TNF, TIMP1, CCL2, IL4, IL5
45
Show member pathways
8.4TNF, TIMP1, CCL2, IL4, IL5
468.1IL4, IFNG, CCL2, MMP9, TNF
47
Show member pathways
7.9TNF, TIMP1, CCL2, IFNG, IL4, IL5
48
Show member pathways
7.9TNF, TIMP1, CCL2, IFNG, IL4, IL5

Compounds for genes affiliated with Scleritis

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Compounds related to Scleritis according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1tranilast449.2TIMP1, IFNG, MMP9
2methylcellulose449.1IL4, TIMP1, IL5, IFNG
3interferon gamma449.1IFNG, IL4, TNF
4bleomycin44 1210.0TIMP1, IL5, IL4, CCL2, MMP9
5ribavirin44 50 1210.9TIMP1, IL4, IFNG, MMP9
6budesonide44 50 1210.9IL4, IFNG, IL5, TNF
7polymyxin b448.9IL4, TNF, IFNG, CCL2
8polyinosinic-polycytidylic acid448.9TNF, IL5, IL4, IFNG
9rolipram44 60 2910.9IL4, IFNG, TNF, IL5
10poly(i-c)448.9IFNG, IL5, IL4, TNF
11parthenolide44 39.8IFNG, CCL2, TNF, MMP9
12amphotericin b448.8IL1RAPL2, IL5, IL4, IFNG
13il-12448.7IL4, CCL2, TNF, IL5, IFNG
14ccl344 299.7IFNG, CCL2, MMP9, TNF
15gm-csf44 299.6CCL2, TNF, IL4, IL5, IFNG
16tarc448.6IFNG, CCL2, TNF, IL5, IL4
17fluticasone propionate44 50 60 1211.6IL4, IFNG, MMP9, IL5, TNF
18imiquimod44 60 29 1211.6IL5, IFNG, TNF, IL1RAPL2
19tacrolimus44 50 1210.5IL5, IL4, IFNG, TIMP1, TNF
20pdtc448.5CCL2, MMP9, TNF, IFNG, IL4
21etanercept44 50 1210.4IFNG, TNF, TIMP1, IL1RAPL2
22ionomycin448.4IFNG, TNF, PRTN3, IL4, IL5
23ly294002448.3IL5, TNF, MMP9, CCL2, TIMP1, IL4
24leukotriene b444 60 2510.3CCL2, IL1RAPL2, MMP9, IL5, TNF
2515-deoxy-delta-12,14-prostaglandin j2448.2IL4, IFNG, TNF, CCL2
26pentoxifylline44 129.2IL1RAPL2, IL4, TNF, IFNG
27butyrate448.2TNF, TIMP1, MMP9, IL5, IFNG
28tgf beta1448.2TNF, TIMP1, MMP9, CCL2, IL1RAPL2
29n acetylcysteine448.2IL4, CCL2, MMP9, TIMP1, TNF
30methotrexate50 44 1210.1TNF, IL5, IL1RAPL2, MMP9, TIMP1
31fmlp448.1IL5, PRTN3, TNF, IL1RAPL2, CCL2
32neopterin448.1IL4, IFNG, TNF, IL1RAPL2
33herbimycin a44 608.9TNF, MMP9, TIMP1, CCL2, IL5, IL4
34rosiglitazone29 44 50 25 1211.9TIMP1, IL1RAPL2, IL4, TNF, MMP9, CCL2
35sb 20358044 608.9TNF, IL5, MMP9, IL4, IFNG, CCL2
36il 10447.9IL5, IFNG, CCL2, TNF, IL1RAPL2, IL4
37indomethacin44 29 60 1210.8IL5, IL4, IFNG, TIMP1, TNF, IL1RAPL2
38ivig447.8MMP9, IFNG, IL5, IL4, IL1RAPL2, TNF
39genistein44 29 60 3 25 1212.7TNF, IL5, MMP9, TIMP1, IFNG, PRTN3
40simvastatin44 50 60 29 25 1212.7TNF, MMP9, CCL2, IFNG, IL4, IL1RAPL2
41infliximab44 50 129.7IL1RAPL2, IL4, IFNG, PRTN3, TIMP1, TNF
42histamine44 29 259.5TNF, IL4, IFNG, CCL2, TIMP1, IL5
43cyclosporin a44 29 609.4IFNG, IL1RAPL2, TNF, TIMP1, MMP9, IL4
44actinomycin d447.3IL1RAPL2, MMP9, IL4, IFNG, TNF, TIMP1
45retinoic acid44 258.2TNF, PRTN3, TIMP1, MMP9, IL5, IL1RAPL2
46rantes447.1TNF, IL5, IL1RAPL2, TIMP1, MMP9, CCL2
47pge2447.0IL1RAPL2, IL5, IL4, CCL2, IFNG, MMP9
48dexamethasone44 50 29 1210.0IL1RAPL2, IFNG, MMP9, IL4, IL5, CCL2
49vegf447.0IL1RAPL2, IFNG, TIMP1, IL5, IL4, CCL2
50cycloheximide446.5TNF, MMP9, PRTN3, IFNG, CCL2, IL4

GO Terms for genes affiliated with Scleritis

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Cellular components related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL4, IFNG, TNF
2extracellular spaceGO:0056157.7IL5, IL4, IFNG, CCL2, MMP9, TNF
3extracellular regionGO:0055767.5TNF, TIMP1, MMP9, CCL2, IFNG, IL5

Biological processes related to Scleritis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.9IL4, IL5
2positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
3positive regulation of podosome assemblyGO:0718039.9IL5, TNF
4positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
5defense response to protozoanGO:0428329.8IFNG, IL4
6positive regulation of synaptic transmissionGO:0508069.8CCL2, TNF
7lipopolysaccharide-mediated signaling pathwayGO:0316639.7CCL2, TNF
8response to activityGO:0148239.7TNF, CCL2
9protein kinase B signalingGO:0434919.7CCL2, TNF
10positive regulation of vitamin D biosynthetic processGO:0605579.7IFNG, TNF
11positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
12cellular response to organic cyclic compoundGO:0714079.7CCL2, TNF
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
14neutrophil chemotaxisGO:0305939.6IFNG, CCL2
15negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF
16positive regulation of osteoclast differentiationGO:0456729.6IFNG, TNF
17protein import into nucleus, translocationGO:0000609.6IFNG, TNF
18positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
19extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
20response to mechanical stimulusGO:0096129.5CCL2, TNF
21positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL5, IL4, TNF
22positive regulation of T cell proliferationGO:0421029.4IL4, IFNG
23response to cytokineGO:0340979.4IL4, TIMP1
24humoral immune responseGO:0069599.3IFNG, CCL2, TNF
25positive regulation of chemokine biosynthetic processGO:0450809.3IL4, IFNG, TNF
26inflammatory responseGO:0069549.3IL5, CCL2, TNF
27extracellular matrix organizationGO:0301989.1TNF, TIMP1, MMP9
28response to drugGO:0424938.9TNF, CCL2, IFNG, IL4
29cytokine-mediated signaling pathwayGO:0192218.8CCL2, IFNG, IL5, IL1RAPL2

Molecular functions related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL5, IL4, IFNG, TNF

Products for genes affiliated with Scleritis

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Sources for Scleritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet