MCID: SCL015
MIFTS: 61

Scleritis malady

Eye diseases category
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Summaries for Scleritis

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Wikipedia:65 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

MalaCards based summary: Scleritis, also known as scleritis, unspecified, is related to arthritis and blau syndrome. An important gene associated with Scleritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug medrysone and the compounds tranilast and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and thyroid, and related mouse phenotypes are liver/biliary system and craniofacial.

Aliases & Classifications for Scleritis

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Scleritis, Aliases & Descriptions:

Name: Scleritis 8 10 62
Scleritis, Unspecified 8 62
 
Unspecified Scleritis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:13452
ICD9CM27 379.00
MeSH34 D015423
ICD1025 H15.0

Related Diseases for Scleritis

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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TNF, TIMP1
2blau syndrome30.4TNF
3uveitis30.3TNF, CCL2, IFNG, IL4
4vasculitis30.2CCL2, TNF, PRTN3, IL1RAPL2
5allergic conjunctivitis30.2IL5, IL4
6psoriatic arthritis30.1TNF, IL1RAPL2
7hepatitis c30.1IL1RAPL2, PRTN3, IFNG
8pneumonia30.1TNF, CCL2, IL5, IL1RAPL2
9ankylosing spondylitis30.0PRTN3, IL1RAPL2, TNF
10connective tissue disease30.0PRTN3, CCL2, IL4, TNF
11ulcerative colitis29.9TNF, PRTN3
12lepromatous leprosy29.9IFNG, IL4
13sarcoidosis29.9CCL2, IFNG, TNF, IL1RAPL2
14kawasaki disease29.8TIMP1, CCL2, MMP9
15toxic shock syndrome29.8IFNG, TNF
16vascular disease29.8CCL2, PRTN3, MMP9
17tuberculosis29.7IL4, TNF, IL1RAPL2, IFNG
18melanoma29.4TNF, IFNG, PRTN3, MMP9, TIMP1, IL4
19graft versus host disease29.4IFNG, IL4, IL1RAPL2, TNF
20colitis29.4IFNG, IL1RAPL2, IL4, TNF
21leukemia29.3IFNG, IL4, IL1RAPL2, PRTN3, TNF
22periodontitis29.3TIMP1, IL1RAPL2, CCL2, TNF, MMP9
23rheumatoid arthritis29.0IL1RAPL2, IFNG, CCL2, PRTN3, MMP9, IL4
24inflammatory bowel disease28.9IL1RAPL2, IL4, IFNG, CCL2, PRTN3, TNF
25systemic lupus erythematosus28.9IL1RAPL2, IL4, IFNG, CCL2, TNF, PRTN3
26psoriasis28.8IFNG, IL5, IL4, IL1RAPL2, TNF, CCL2
27multiple sclerosis28.2IL5, IL1RAPL2, IFNG, CCL2, MMP9, TIMP1
28posterior scleritis10.8
29anterior scleritis10.6
30eosinophilic fasciitis10.5IL5
31kimura disease10.5IL5
32eosinophilia-myalgia syndrome10.5IL5
33keratoconjunctivitis10.5IL5
34strongyloidiasis10.5IL5
35choroiditis10.5
36keratitis10.5
37pulpitis10.5TIMP1
38retinitis10.5
39angiostrongyliasis10.4MMP9
40wegener's granulomatosis10.4
41sinusitis10.4IL5, PRTN3
42pterygium10.4
43churg-strauss syndrome10.3IL5, PRTN3
44aspergillosis10.3IFNG
45strabismus10.3
46retinal detachment10.3
47skin disease10.3MMP9
48spondylarthropathy10.3IL1RAPL2, TNF
49bronchitis10.3PRTN3, IL5
50egg allergy10.3IL4, IL5

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to scleritis

Symptoms for Scleritis

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Drugs & Therapeutics for Scleritis

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Drug clinical trials:

Search ClinicalTrials for Scleritis

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Scleritis

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Anatomical Context for Scleritis

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MalaCards organs/tissues related to Scleritis:

32
Eye, Neutrophil, Thyroid, Bone, Testes, T cells, Lung, Breast, Endothelial, Bone marrow

Animal Models for Scleritis or affiliated genes

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MGI Mouse Phenotypes related to Scleritis:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4TNF, CCL2, IFNG, IL4, IL5
2MP:00053828.2IL4, IFNG, CCL2, TNF
3MP:00053918.2IL4, IFNG, CCL2, MMP9, TNF
4MP:00053908.2TNF, MMP9, CCL2, IFNG, IL4
5MP:00020068.1TNF, TIMP1, MMP9, CCL2, IFNG, IL5
6MP:00107718.1IL4, IFNG, CCL2, MMP9, TNF
7MP:00053858.1TNF, TIMP1, MMP9, CCL2, IFNG
8MP:00053888.0TNF, TIMP1, MMP9, IFNG, IL4, IL5
9MP:00053818.0TNF, MMP9, CCL2, IFNG, IL4, IL5
10MP:00107687.7TIMP1, MMP9, CCL2, IFNG, IL4, TNF
11MP:00053897.7TNF, TIMP1, MMP9, CCL2, IFNG, IL4
12MP:00053787.6TNF, TIMP1, MMP9, CCL2, IFNG, IL4
13MP:00053767.6TNF, TIMP1, MMP9, CCL2, IFNG, IL4
14MP:00053977.2IL5, TNF, TIMP1, MMP9, PRTN3, CCL2
15MP:00053877.2TNF, TIMP1, MMP9, PRTN3, CCL2, IFNG

Publications for Scleritis

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Articles related to Scleritis:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Infectious Pseudomonas scleritis after strabismus surgery. (23871294)
2013
2
Cytomegalovirus-related Scleritis. (23876078)
2013
3
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. (22395202)
2013
4
Necrobiotic xanthogranuloma associated with necrotizing scleritis. (22814320)
2012
5
Posterior scleritis resembling acute retinal necrosis syndrome. (25390725)
2012
6
Scleritis therapy. (22015381)
2012
7
Scleritis--Wegener's granulomatosis. (23256431)
2012
8
Necrotizing scleritis in a patient positive for both c- and p-ANCA without underlying systemic vasculitis. (21792741)
2011
9
Interferon-gamma release assay in tuberculous scleritis. (21402999)
2011
10
Necrotizing nocardial scleritis successfully treated with surgical debridement and topical polyvinyl alcohol iodine and antibiotics. (21689016)
2011
11
Successful treatment of severe nodular scleritis with adalimumab. (20155432)
2010
12
Infectious scleritis and surgical induced necrotizing scleritis. (19521437)
2010
13
An update on the cause and treatment of scleritis. (20842032)
2010
14
A case of necrotizing scleritis resulting from Pseudomonas aeruginosa. (19724201)
2009
15
Infliximab for the treatment of active scleritis. (19506593)
2009
16
Scleritis and systemic disease association in a community-based referral practice. (19837380)
2009
17
Inadvertent subretinal triamcinolone injection in a case of recurrent scleritis. (19610249)
2009
18
Surgically induced necrotising scleritis following three-port pars plana vitrectomy without scleral buckling: a series of three cases. (17304259)
2008
19
Nodular scleritis following alendronate therapy. (18569796)
2008
20
Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess. (18833414)
2008
21
Pseudomonas scleritis resistant to fourth-generation fluoroquinolones in a patient without prior trauma or surgery. (18569805)
2008
22
HIV-seropositive patient with Sweet's syndrome and nodular scleritis, showing dramatic response after adding dapsone to systemic corticosteroid therapy. (18717866)
2008
23
Comment on 'smoking delays the response to treatment in episcleritis and scleritis'. (16470220)
2006
24
Necrotizing scleritis due to varicella zoster infection: a case report. (17056468)
2006
25
Giant nodular posterior scleritis simulating choroidal melanoma. (16770031)
2006
26
Bilateral surgically induced necrotising scleritis with secondary superinfection. (15615764)
2005
27
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. (15958765)
2005
28
Deep intramuscular methylprednisolone treatment of recurrent scleritis. (15804772)
2005
29
Anterior scleritis, scleral thinning, and intraocular pressure measurement. (16321890)
2005
30
Evaluation of patients with scleritis for systemic disease. (15019326)
2004
31
Necrotizing scleritis after intraocular surgery associated with the use of polyester nonabsorbable sutures. (14522309)
2003
32
Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis. (14533032)
2003
33
Early manifestation of vogt-koyanagi-harada disease as unilateral posterior scleritis. (12457922)
2002
34
Self-inflicted anterior scleritis. (11150288)
2001
35
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
36
Cilioretinal artery occlusion in posterior scleritis. (10872939)
2000
37
Posterior scleritis: clinical profile and imaging characteristics. (10218301)
1998
38
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
39
Scleritis after glaucoma filtering surgery with mitomycin C. (9097808)
1995
40
Scleritis associated with coxsackle B type 5 infection. (7958049)
1994
41
Posterior scleritis as a fundus mass. (8183510)
1994
42
Clinical course of scleritis induced by cataract surgery: a case report. (7927636)
1994
43
Posterior scleritis: ultrasound and clinical findings. (8343917)
1993
44
Scleritis associated with varicella-zoster disciform stromal keratitis. (1317994)
1992
45
Scleritis and Wegener's granulomatosis in children. (1882959)
1991
46
Acute scleritis in porphyria cutanea tarda. (2330942)
1990
47
Clinical manifestations of brawny scleritis. (434079)
1979
48
Clinical manifestations of brawny scleritis. (677204)
1978
49
Rheumatoid scleritis producing exophthalmos. (1131332)
1975
50
Scleritis and aortic incompetence. Two manifestations of connective tissue disease. (4394498)
1970

Variations for Scleritis

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Expression for genes affiliated with Scleritis

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Expression patterns in normal tissues for genes affiliated with Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for genes affiliated with Scleritis

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Pathways related to Scleritis according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TIMP1, CCL2
29.7IL4, IL5
39.6CCL2, MMP9
49.6CCL2, MMP9
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5IFNG, IL4
69.5TNF, CCL2
79.4MMP9, TNF
8
Show member pathways
9.3CCL2, TIMP1, IL4
9
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.3TNF, IFNG
10
Show member pathways
9.3TNF, IFNG
119.3IFNG, TNF
129.3TNF, IFNG
139.3IFNG, TNF
14
Show member pathways
IL27-mediated signaling events37
9.3TNF, IFNG
15
Show member pathways
9.3TNF, IFNG
169.3IFNG, TNF
179.2IFNG, IL4, IL5
18
Show member pathways
Type III interferon signaling37
9.2IL4, IFNG, IL5
199.2IL4, IL5, IFNG
209.2IL5, IFNG, IL4
219.1IL4, TNF, IL5
22
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.1IL4, IL5, TNF
23
Show member pathways
9.1MMP9, TIMP1, TNF
24
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0TNF, CCL2, MMP9
259.0TNF, CCL2, MMP9
26
Show member pathways
thioredoxin pathway37
9.0IFNG, CCL2, TNF
279.0TNF, IFNG, CCL2
289.0CCL2, TNF, IFNG
299.0TNF, CCL2, IFNG
30
Show member pathways
Immune response CD16 signaling in NK cells60
8.9IL4, IFNG, TNF
31
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IL4, IFNG, TNF
32
Show member pathways
8.9TNF, IL4, IFNG
338.9IFNG, TNF, MMP9
34
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6TIMP1, TNF, IFNG, CCL2
35
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.6IL4, IL5, IFNG, TNF
36
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.6IL4, IFNG, TNF, IL5
378.6IFNG, IL4, IL5, TNF
38
Show member pathways
8.6TNF, IFNG, IL5, IL4
398.6IL5, IL4, IFNG, TNF
40
Show member pathways
8.6IL5, IL4, IFNG, TNF
41
Show member pathways
8.5IL4, TNF, CCL2, IFNG
42
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5TNF, IFNG, CCL2, MMP9
43
Show member pathways
8.4IL5, IL4, CCL2, TNF, TIMP1
44
Show member pathways
8.4IL5, IL4, CCL2, TIMP1, TNF
45
Show member pathways
8.4IL5, TIMP1, TNF, IL4, CCL2
468.1TNF, MMP9, CCL2, IL4, IFNG
47
Show member pathways
7.9TNF, CCL2, IFNG, IL4, IL5, TIMP1
48
Show member pathways
7.9IFNG, TNF, TIMP1, IL5, IL4, CCL2

Compounds for genes affiliated with Scleritis

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Compounds related to Scleritis according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1tranilast449.2TIMP1, IFNG, MMP9
2methylcellulose449.1IL4, TIMP1, IL5, IFNG
3interferon gamma449.1IFNG, IL4, TNF
4bleomycin44 1110.0TIMP1, IL5, IL4, CCL2, MMP9
5ribavirin44 50 1110.9TIMP1, IL4, IFNG, MMP9
6budesonide44 50 1110.9IL4, IFNG, IL5, TNF
7polymyxin b448.9IL4, TNF, IFNG, CCL2
8polyinosinic-polycytidylic acid448.9TNF, IL5, IL4, IFNG
9rolipram44 61 2810.9IL4, IFNG, TNF, IL5
10poly(i-c)448.9IFNG, IL5, IL4, TNF
11parthenolide44 29.8IFNG, CCL2, TNF, MMP9
12amphotericin b448.8IL1RAPL2, IL5, IL4, IFNG
13il-12448.7IL4, CCL2, TNF, IL5, IFNG
14ccl344 289.7IFNG, CCL2, MMP9, TNF
15gm-csf44 289.6CCL2, TNF, IL4, IL5, IFNG
16tarc448.6IFNG, CCL2, TNF, IL5, IL4
17fluticasone propionate44 50 61 1111.6IL4, IFNG, MMP9, IL5, TNF
18imiquimod44 61 28 1111.6IL5, IFNG, TNF, IL1RAPL2
19tacrolimus44 50 1110.5IL5, IL4, IFNG, TIMP1, TNF
20pdtc448.5CCL2, MMP9, TNF, IFNG, IL4
21etanercept44 50 1110.4IFNG, TNF, TIMP1, IL1RAPL2
22ionomycin448.4IFNG, TNF, PRTN3, IL4, IL5
23ly294002448.3IL5, TNF, MMP9, CCL2, TIMP1, IL4
24leukotriene b444 61 2410.3CCL2, IL1RAPL2, MMP9, IL5, TNF
2515-deoxy-delta-12,14-prostaglandin j2448.2IL4, IFNG, TNF, CCL2
26pentoxifylline44 119.2IL1RAPL2, IL4, TNF, IFNG
27butyrate448.2TNF, TIMP1, MMP9, IL5, IFNG
28tgf beta1448.2TNF, TIMP1, MMP9, CCL2, IL1RAPL2
29n acetylcysteine448.2IL4, CCL2, MMP9, TIMP1, TNF
30methotrexate50 44 1110.1TNF, IL5, IL1RAPL2, MMP9, TIMP1
31fmlp448.1IL5, PRTN3, TNF, IL1RAPL2, CCL2
32neopterin448.1IL4, IFNG, TNF, IL1RAPL2
33herbimycin a44 618.9TNF, MMP9, TIMP1, CCL2, IL5, IL4
34rosiglitazone28 44 50 24 1111.9TIMP1, IL1RAPL2, IL4, TNF, MMP9, CCL2
35sb 20358044 618.9TNF, IL5, MMP9, IL4, IFNG, CCL2
36il 10447.9IL5, IFNG, CCL2, TNF, IL1RAPL2, IL4
37indomethacin44 28 61 1110.8IL5, IL4, IFNG, TIMP1, TNF, IL1RAPL2
38ivig447.8MMP9, IFNG, IL5, IL4, IL1RAPL2, TNF
39genistein44 28 61 2 24 1112.7TNF, IL5, MMP9, TIMP1, IFNG, PRTN3
40simvastatin44 50 61 28 24 1112.7TNF, MMP9, CCL2, IFNG, IL4, IL1RAPL2
41infliximab44 50 119.7IL1RAPL2, IL4, IFNG, PRTN3, TIMP1, TNF
42histamine44 28 249.5TNF, IL4, IFNG, CCL2, TIMP1, IL5
43cyclosporin a44 28 619.4IFNG, IL1RAPL2, TNF, TIMP1, MMP9, IL4
44actinomycin d447.3IL1RAPL2, MMP9, IL4, IFNG, TNF, TIMP1
45retinoic acid44 248.2TNF, PRTN3, TIMP1, MMP9, IL5, IL1RAPL2
46rantes447.1TNF, IL5, IL1RAPL2, TIMP1, MMP9, CCL2
47pge2447.0IL1RAPL2, IL5, IL4, CCL2, IFNG, MMP9
48dexamethasone44 50 28 1110.0IL1RAPL2, IFNG, MMP9, IL4, IL5, CCL2
49vegf447.0IL1RAPL2, IFNG, TIMP1, IL5, IL4, CCL2
50cycloheximide446.5TNF, MMP9, PRTN3, IFNG, CCL2, IL4

GO Terms for genes affiliated with Scleritis

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Cellular components related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL4, IFNG, TNF
2extracellular spaceGO:0056157.7IL4, TNF, MMP9, CCL2, IFNG, IL5
3extracellular regionGO:0055767.5IL5, TNF, TIMP1, MMP9, CCL2, IFNG

Biological processes related to Scleritis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.9IL5, IL4
2positive regulation of isotype switching to IgG isotypesGO:0483049.9IFNG, IL4
3positive regulation of podosome assemblyGO:0718039.9IL5, TNF
4positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL4
5defense response to protozoanGO:0428329.8IFNG, IL4
6positive regulation of synaptic transmissionGO:0508069.8CCL2, TNF
7lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, CCL2
8response to activityGO:0148239.7CCL2, TNF
9positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
10positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7IFNG, TNF
11protein kinase B signalingGO:0434919.7TNF, CCL2
12cellular response to organic cyclic compoundGO:0714079.7TNF, CCL2
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.7IFNG, TNF
14neutrophil chemotaxisGO:0305939.6CCL2, IFNG
15negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF
16positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
17protein import into nucleus, translocationGO:0000609.6IFNG, TNF
18positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, TNF
19extrinsic apoptotic signaling pathwayGO:0971919.5IFNG, TNF
20response to mechanical stimulusGO:0096129.5TNF, CCL2
21positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL5, IL4, TNF
22positive regulation of T cell proliferationGO:0421029.4IL4, IFNG
23response to cytokineGO:0340979.4IL4, TIMP1
24humoral immune responseGO:0069599.3TNF, CCL2, IFNG
25positive regulation of chemokine biosynthetic processGO:0450809.3IL4, IFNG, TNF
26inflammatory responseGO:0069549.3CCL2, IL5, TNF
27extracellular matrix organizationGO:0301989.1MMP9, TNF, TIMP1
28response to drugGO:0424938.9IFNG, CCL2, TNF, IL4
29cytokine-mediated signaling pathwayGO:0192218.8IL5, IL1RAPL2, IFNG, CCL2

Molecular functions related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL5, IL4, IFNG, TNF

Products for genes affiliated with Scleritis

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Sources for Scleritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet