MCID: SCL015
MIFTS: 57

Scleritis malady

Eye diseases category

Summaries for Scleritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

MalaCards: Scleritis, also known as scleritis, unspecified, is related to keratitis and uveitis. An important gene associated with Scleritis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Leishmaniasis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drug medrysone and the compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotypes are reproductive system and vision/eye.

Aliases & Classifications for Scleritis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

scleritis 8 10 60
scleritis, unspecified 8
unspecified scleritis 8


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Disease Ontology8 DOID:13452
MeSH34 D015423
ICD9CM27 379.00
ICD1025 H15.0

Related Diseases for Scleritis

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17GeneCards, 18GeneDecks
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Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 350)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis30.6MMP9
2uveitis30.6CCL2, IFNG, TNFRSF1B, TNF, HLA-B, IL4
3arthritis30.5TNF, TIMP1
4rheumatoid arthritis30.5TIMP1, CCL2, IFNG, TNFRSF1B, TNF, PRTN3
5wegener's granulomatosis30.4PRTN3
6melanoma30.3TIMP1, IFNG, TNF, HLA-B, PRTN3, IL4
7myositis30.2TNFRSF1B, HLA-B, IL1RAPL2
8vasculitis30.1IL1RAPL2, PRTN3, HLA-B, TNF, TNFRSF1B, CCL2
9eye disease30.0CCL2
10crohn's disease30.0TNFRSF1B, TNF
11hepatitis30.0HLA-B, IL1RAPL2
12connective tissue disease30.0CCL2, TNF, PRTN3, IL4
13pneumonia30.0IL1RAPL2, IL5, TNF, TNFRSF1B, CCL2
14tuberculosis30.0IFNG, TNFRSF1B, TNF, IL4, IL1RAPL2
15sarcoidosis30.0IFNG, CCL2, TNFRSF1B, TNF, IL1RAPL2
16hepatitis c30.0TIMP1, IFNG, TNFRSF1B, TNF, IL4
17hypertension29.9MMP9, CCL2
18herpes simplex29.9TNFRSF1B, HLA-B, IL1RAPL2
19influenza29.9HLA-B, IFNG
20behcet's disease29.9HLA-B, TNF, TNFRSF1B
21squamous cell carcinoma29.8TIMP1, TNFRSF1B, HLA-B, PRTN3, IL1RAPL2, MMP9
22polymyalgia rheumatica29.7IL1RAPL2
23lung cancer29.7MMP9
24familial mediterranean fever29.6TNF
25blau syndrome29.6TNF
26acquired immunodeficiency syndrome29.6HLA-B
27vascular disease29.6TNF, TIMP1
28allergic conjunctivitis29.6IL5, IL4
29sjogren's syndrome29.6IL1RAPL2, PRTN3, TNFRSF1B
30lepromatous leprosy29.6IFNG, IL4
31psoriatic arthritis29.6TNFRSF1B, TNF, IL1RAPL2
32kawasaki disease29.6TIMP1, CCL2, MMP9
33toxic shock syndrome29.6TNF, IFNG
34reactive arthritis29.6HLA-B, PRTN3
35graft versus host disease29.6IFNG, TNF, IL4, IL1RAPL2
36periodontitis29.6TIMP1, CCL2, TNF, IL1RAPL2, MMP9
37ankylosing spondylitis29.6TNFRSF1B, TNF, HLA-B, PRTN3, IL1RAPL2
38breast cancer29.6TIMP1, TNFRSF1B, HLA-B, PRTN3, IL1RAPL2, MMP9
39leukemia29.6IL1RAPL2, IL4, PRTN3, HLA-B, TNF, IFNG
40ulcerative colitis29.6IFNG, TNFRSF1B, TNF, HLA-B, PRTN3, IL4
41inflammatory bowel disease29.6CCL2, IFNG, TNFRSF1B, TNF, HLA-B, PRTN3
42psoriasis29.6IL1RAPL2, IL4, IL5, HLA-B, TNF, TNFRSF1B
43multiple sclerosis29.6TIMP1, CCL2, IFNG, TNFRSF1B, TNF, HLA-B
44posterior scleritis10.8
45anterior scleritis10.6
46choroiditis10.4
47retinitis10.4
48pterygium10.4
49glaucoma10.3
50retinal detachment10.3

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to scleritis

Clinical Features for Scleritis

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Drugs & Therapeutics for Scleritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Scleritis

Drug clinical trials:

Search ClinicalTrials for Scleritis

Search NIH Clinical Center for Scleritis

Search CenterWatch for Scleritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Scleritis

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Anatomical Context for Scleritis

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32MalaCards
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MalaCards organs/tissues related to Scleritis:

32
Eye, Thyroid, Testes, Bone, Lung, Breast, T cells, Endothelial, Bone marrow

Animal Models for Scleritis or affiliated genes

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36MGI
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Publications for Scleritis

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50PubMed
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Articles related to Scleritis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Scleritis: Immunopathogenesis and molecular basis for therapy. (23454614)
2013
2
Necrotizing scleritis as a complication of cosmetic eye whitening procedure. (23514228)
2013
3
Necrotizing scleritis after strabismus surgery in thyroid eye disease. (24160978)
2013
4
Bilateral scleritis and sclerokeratitis associated with IgA nephropathy. (22411460)
2012
5
Pediatric posterior scleritis. (22749104)
2012
6
Regional corticosteroids for scleritis. (23034302)
2012
7
Clinical features and presentation of infectious scleritis from herpes viruses: a report of 35 cases. (22463821)
2012
8
Necrotizing scleritis in a patient positive for both c- and p-ANCA without underlying systemic vasculitis. (21792741)
2011
9
Rituximab treatment for persistent scleritis associated with rheumatoid arthritis. (20482403)
2010
10
Clinical features, predisposing factors, and treatment outcomes of scleritis in the Korean population. (21165230)
2010
11
Subconjunctival triamcinolone treatment for non-necrotising anterior scleritis. (20447959)
2010
12
Evaluation of sub-Tenon triamcinolone acetonide injections in the treatment of scleritis. (19875093)
2010
13
A case of atypical Cogan's syndrome with posterior scleritis and uveitis. (20020252)
2009
14
Uveal metastasis from testicular choriocarcinoma presenting as scleritis. (19491960)
2009
15
Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess. (18833414)
2008
16
Penicillium endophthalmitis in necrotizing scleritis treated with topical corticosteroid and cyclosporin A. (19089577)
2008
17
An immunohistochemical investigation of canine idiopathic granulomatous scleritis. (18190346)
2008
18
Necrotizing scleritis and peripheral ulcerative keratitis in a case of Sweet's syndrome found culture-positive for Mycobacterium tuberculosis. (18782495)
2008
19
Antineutrophil cytoplasmic antibody-associated active scleritis. (18474775)
2008
20
Immunologic markers as potential predictors of systemic autoimmune disease in patients with idiopathic scleritis. (18061135)
2008
21
Recreational use of 3,4-methylenedioxymethamphetamine ('ecstasy') relieving symptoms of posterior scleritis. (17891054)
2007
22
Posterior scleritis and its association with HLA B27 haplotype. (17579295)
2007
23
Scleritis and peripheral ulcerative keratitis. (18037120)
2007
24
Therapy insight: scleritis and its relationship to systemic autoimmune disease. (17396107)
2007
25
Necrotizing scleritis following diode laser trans-scleral cyclophotocoagulation. (16921220)
2006
26
Inverse hypopyon as the presenting feature of infectious scleritis in a case of tropical pyomyositis. (17224963)
2006
27
Expression of tumor necrosis factor alpha and matrix metalloproteinase-9 in surgically induced necrotizing scleritis. (16319517)
2006
28
Successful treatment of surgically induced necrotizing scleritis with tacrolimus. (15670089)
2005
29
Posterior scleritis causing combined central retinal artery and vein occlusion. (15187677)
2004
30
Sarcoidosis and scleritis. (15512978)
2004
31
Necrotizing scleritis after intraocular surgery associated with the use of polyester nonabsorbable sutures. (14522309)
2003
32
Bilateral combined retinal and choroidal detachment in antineutrophil cytoplasmic antibody-positive scleritis. (12859271)
2003
33
Bilateral non-specific orbital inflammation (orbital "pseudotumour"), posterior scleritis, and anterior uveitis associated with hypothyroidism in a child. (12140225)
2002
34
Necrotising scleritis after bare sclera excision of pterygium. (10966964)
2000
35
Posterior scleritis: clinical profile and imaging characteristics. (10218301)
1998
36
Scleritis associated with acute febrile neutrophilic dermatosis (Sweet's syndrome) (9602638)
1998
37
Scleritis and mucosal-associated lymphoid tissue lymphoma: a new masquerade syndrome. (8618763)
1996
38
Posterior scleritis with annular ciliochoroidal detachment. (7485375)
1995
39
Scleritis associated with coxsackle B type 5 infection. (7958049)
1994
40
Severity of scleritis and episcleritis. (8115160)
1994
41
Trimethoprim-sulfamethoxazole for scleritis associated with limited Wegener's granulomatosis: use of histopathology and anti-neutrophil cytoplasmic antibody (ANCA) test. (8500327)
1993
42
Computed tomography and magnetic resonance imaging in the diagnosis of posterior scleritis. (8460885)
1993
43
Use of orbital floor steroids in the management of patients with uniocular non-necrotising scleritis. (2043574)
1991
44
Use of cyclosporin in the management of steroid dependent non-necrotising scleritis. (2043575)
1991
45
Ultrastructural changes in scleral proteoglycans precede destruction of the collagen fibril matrix in necrotizing scleritis. (3371895)
1988
46
Surgical treatment of necrotizing scleritis. (3431895)
1987
47
Changes at the periphery of a lesion in necrotising scleritis: anterior segment fluorescein angiography correlated with electron microscopy. (4041412)
1985
48
Migration of acetylated hemicellulose from capillary hemodialyzer to blood, causing scleritis and/or iritis. (6508598)
1984
49
Clinical manifestations of brawny scleritis. (434079)
1979
50
Angle-closure glaucoma secondary to posterior scleritis. (656360)
1978

Genetic Variations for Scleritis

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Expression for genes affiliated with Scleritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for genes affiliated with Scleritis

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Sources:
29KEGG, 52R&D Systems, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Scleritis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL5
29.9IL4, IL5
39.7CCL2, TNF
4
Hide members
9.7IL5, TNFRSF1B, TIMP1
5
Hide members
9.7IL5, TNFRSF1B, TIMP1
6
Hide members
9.7TIMP1, TNFRSF1B, IL5
7
Hide members
9.6TIMP1, CCL2, IL5
89.5IFNG, IL5, IL4
99.5IFNG, IL5, IL4
109.5IL4, IL5, IFNG
11
Hide members
9.5MMP9, TNF, TIMP1
129.4TNF, IL5, IL4
13
Hide members
9.4TNF, TNFRSF1B, IFNG
14
Hide members
9.4TNF, TNFRSF1B, IFNG
15
Hide members
9.4TNF, TNFRSF1B, IFNG
169.3MMP9, TNF, IFNG
179.3CCL2, IFNG, TNF
189.3CCL2, IFNG, TNF
199.2IFNG, TNFRSF1B, IL5, IL4
209.1NSMAF, TNFRSF1B, TNF
21
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9.1MMP9, TNF, TNFRSF1B, CCL2
229.1CCL2, TNFRSF1B, TNF, MMP9
23
Hide members
9.1IFNG, TNF, IL5, IL4
249.1IL4, IL5, TNF, IFNG
25
Hide members
9.1IL4, IL5, TNF, IFNG
269.1CCL2, TNF, IL4, MMP9
27
Development PDGF signaling via STATs and NF-kB
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9.0TIMP1, CCL2, IFNG, TNF
28
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9.0CCL2, IFNG, TNF, MMP9
29
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8.7IFNG, TNF, HLA-B, IL5, IL4
30
Hide members
8.6IL4, HLA-B, TNF, IFNG, CCL2
31
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8.5TIMP1, CCL2, TNFRSF1B, TNF, IL5, IL4
32
Hide members
8.4IL4, IL5, HLA-B, TNF, TNFRSF1B, IFNG

Compounds for genes affiliated with Scleritis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Scleritis according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1pge24410.6MMP9
2endotoxin4410.6TNFRSF1B
3rosiglitazone44 49 28 11 2414.3TIMP1, IL4
4pdtc4410.2MMP9, CCL2
5cycloheximide4410.1IL1RAPL2
6gm-csf44 2811.1IFNG, TNF
7amphotericin b4410.0IL1RAPL2
8indomethacin44 59 28 1112.7IL5, IL1RAPL2
9tacrolimus44 49 1111.6IFNG, TIMP1, IL5, IL4
10con a449.5IFNG, TNFRSF1B, IL5, IL4
11ivig449.4TNFRSF1B, IL1RAPL2, IFNG
12interferon gamma449.4TNF, IL4, IFNG
13bleomycin44 1110.3CCL2, TIMP1, IL5, IL4, MMP9
14budesonide44 49 1111.3TNF, IL4, IL5, IFNG
15polymyxin b449.2IFNG, CCL2, IL4, TNF
16parthenolide44 210.2IFNG, TNF, MMP9, CCL2
17fluticasone propionate44 49 59 1112.2IFNG, MMP9, IL4, IL5, TNF
18poly(i-c)449.2TNF, IFNG, IL4, IL5
19ribavirin44 49 1111.2IL4, HLA-B, IFNG, TIMP1, MMP9
20il-12449.2IL4, IL5, TNF, IFNG, CCL2
21tarc449.1TNF, IL5, IL4, IFNG, CCL2
22polyinosinic-polycytidylic acid449.1IL5, HLA-B, IL4, TNF, IFNG
23cyclosporin a44 28 5911.0IFNG, IL1RAPL2, HLA-B, TNFRSF1B
24dexamethasone44 49 28 1112.0TNFRSF1B, TIMP1, IL5, IL1RAPL2, MMP9
25fmlp449.0PRTN3, IL5, TNFRSF1B, IL1RAPL2
26methylcellulose449.0IFNG, IL4, TIMP1, IL5
27imiquimod44 28 59 1111.9IFNG, IL1RAPL2, IL5, TNF
28curcumin448.8MMP9, TNF, TNFRSF1B, CCL2, TIMP1
29etanercept44 49 1110.7IL1RAPL2, TNF, TIMP1, IFNG, TNFRSF1B
30ly294002448.6IL5, MMP9, TNF, TNFRSF1B, CCL2, TIMP1
31leukotriene b444 59 2410.6IL1RAPL2, MMP9, CCL2, TNF, IL5
32herbimycin a44 599.6TIMP1, CCL2, IFNG, TNF, IL5, MMP9
33paraffin448.6TIMP1, MMP9, IL5, IL4, HLA-B, CCL2
34sb 20358044 599.6TIMP1, CCL2, IFNG, TNF, IL4, MMP9
35neopterin448.6IL1RAPL2, TNF, TNFRSF1B, IFNG, IL4
36rantes448.5TNF, IL1RAPL2, IL4, HLA-B, IFNG
37ionomycin448.4IL5, IFNG, TNF, PRTN3, IL4
38tgf beta1448.4TIMP1, IL1RAPL2, MMP9, CCL2, TNF
39methotrexate44 49 1110.4TIMP1, TNF, TNFRSF1B, MMP9, IL1RAPL2, IL5
40genistein44 28 59 2 11 2413.3CCL2, TIMP1, IL5, IFNG, TNF, PRTN3
41simvastatin44 49 59 28 11 2413.2TNF, MMP9, IL1RAPL2, IL4, CCL2, IFNG
42fibrinogen448.1MMP9, TNFRSF1B, TNF, HLA-B, IL1RAPL2, CCL2
43adenylate448.1TNFRSF1B, TIMP1, MMP9, IL1RAPL2, IL4, IL5
44il 10448.1IL1RAPL2, IL4, CCL2, IFNG, TNFRSF1B, TNF
45histamine44 28 2410.0IL5, IL4, CCL2, IL1RAPL2, TNF, IFNG
46infliximab44 49 119.9TIMP1, IFNG, TNFRSF1B, TNF, PRTN3, IL1RAPL2
47actinomycin d447.7MMP9, IL4, TNF, TNFRSF1B, CCL2, TIMP1
48vegf447.5MMP9, IL1RAPL2, IL4, IL5, TNF, TNFRSF1B
49serine447.2MMP9, IL1RAPL2, PRTN3, TNF, TNFRSF1B, HLA-B
50retinoic acid44 248.2IFNG, TIMP1, MMP9, TNF, HLA-B, PRTN3

GO Terms for genes affiliated with Scleritis

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16Gene Ontology
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Cellular components related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CCL2, IFNG, TNFRSF1B, TNF, IL5, MMP9
2extracellular spaceGO:0056158.1MMP9, IL4, IL5, TNF, IFNG, CCL2

Biological processes related to Scleritis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:07180310.0TNF, IL5
2positive regulation of isotype switching to IgG isotypesGO:04830410.0IFNG, IL4
3positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, IFNG
4positive regulation of vitamin D biosynthetic processGO:0605579.9IFNG, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9TNF, IFNG
6cellular response to lipopolysaccharideGO:0712229.7TNFRSF1B, IFNG, CCL2
7positive regulation of synaptic transmissionGO:0508069.7TNF, CCL2
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, TNFRSF1B, IFNG
9positive regulation of osteoclast differentiationGO:0456729.6TNF, IFNG
10positive regulation of chemokine biosynthetic processGO:0450809.6IL4, TNF, IFNG
11positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6TNF, IL5, IL4
12humoral immune responseGO:0069599.6TNF, IFNG, CCL2
13negative regulation of growth of symbiont in hostGO:0441309.5IFNG, TNF
14defense response to protozoanGO:0428329.5IL4, IFNG
15cytokine-mediated signaling pathwayGO:0192219.4CCL2, IFNG, HLA-B, IL5
16immune responseGO:0069559.3TNFRSF1B, HLA-B, IL5, IL4
17inflammatory responseGO:0069549.3IL5, TNF, TNFRSF1B, CCL2
18response to drugGO:0424939.2CCL2, IFNG, TNF, IL4

Molecular functions related to Scleritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL5, TNF, IFNG

Products for genes affiliated with Scleritis

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  • Antibodies
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Sources for Scleritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet