MCID: SCL015
MIFTS: 46

Scleritis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Scleritis

MalaCards integrated aliases for Scleritis:

Name: Scleritis 12 50 42 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13452
ICD10 33 H15.0 H15.00
ICD9CM 35 379.00
MeSH 42 D015423
NCIt 47 C119046
UMLS 69 C0036416

Summaries for Scleritis

MalaCards based summary : Scleritis is related to uveitis and choroiditis. An important gene associated with Scleritis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and thyroid, and related phenotypes are immune system and respiratory system

Wikipedia : 72 Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as... more...

Related Diseases for Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
id Related Disease Score Top Affiliating Genes
1 uveitis 31.0 CCL2 TNF
2 choroiditis 30.2 CCL2 TNF
3 lymphoma 29.7 IL4 IL5 TNF
4 rheumatoid arthritis 29.1 CCL2 IL4 ITGB2 TNF
5 systemic lupus erythematosus 28.3 CCL2 IL4 SELE TNF
6 posterior scleritis 12.0
7 anterior scleritis 12.0
8 brawny scleritis 11.9
9 scleroperikeratitis 10.8
10 aortic arch interruption 10.6 IL5 TNF
11 hepatic encephalopathy 10.6 IL5 TNF
12 pneumoconiosis due to talc 10.6 CCL2 TNF
13 antigen-peptide-transporter 2 deficiency 10.6 CCL2 TNF
14 signet ring cell adenocarcinoma 10.6 IL5 TNF
15 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.5 CCL2 TNF
16 islet cell tumor 10.5 CCL2 TNF
17 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.5 CCL2 TNF
18 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.5 SELE TNF
19 steatorrhea 10.5 CCL2 TNF
20 moved to 244450 10.5 SELE TNF
21 riboflavin transporter deficiency 10.5 SELE TNF
22 glioblastoma multiforme 10.5 IL5 TNF
23 dermatomycosis 10.5 SELE TNF
24 ovarian mucinous adenofibroma 10.4 CCL2 TNF
25 myofascial pain syndrome 10.4 CCL2 IL5
26 acute ackee fruit intoxication 10.4 IL4 TNF
27 ampulla of vater neoplasm 10.4 SELE TNF
28 dracunculiasis 10.4 SELE TNF
29 basidiobolomycosis 10.4 IL4 TNF
30 lip cancer 10.4 ITGB2 TNF
31 lagophthalmos 10.4 IL4 TNF
32 high pressure neurological syndrome 10.4 CCL2 TNF
33 dysphagia 10.4 SELE TNF
34 liver leiomyoma 10.4 IL4 TNF
35 rheumatic myocarditis 10.4 SELE TNF
36 conduct disorder 10.4 SELE TNF
37 osmotic diarrhea 10.4 CCL2 TNF
38 oropharyngeal cancer, childhood 10.4 IL4 TNF
39 louping ill 10.4 CCL2 TNF
40 lymphocytic colitis 10.4 IL4 TNF
41 spindle cell hemangioma 10.4 IL4 TNF
42 alkhurma hemorrhagic fever 10.4 IL4 TNF
43 phlyctenulosis 10.4 IL4 TNF
44 disease of mental health 10.3 IL5 TNF
45 marasmus 10.3 IL4 IL5
46 tularemia 10.3 IL4 TNF
47 orbit alveolar rhabdomyosarcoma 10.3 IL4 IL5
48 angioid streaks of choroid 10.3 IL4 IL5
49 early-onset zonular cataract 10.3 IL4 TNF
50 x-linked intellectual disability, van esch type 10.3 IL4 IL5

Comorbidity relations with Scleritis via Phenotypic Disease Network (PDN):


Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Scleritis:



Diseases related to Scleritis

Symptoms & Phenotypes for Scleritis

MGI Mouse Phenotypes related to Scleritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 CCL2 IL4 IL5 ITGB2 MMP9 SELE
2 respiratory system MP:0005388 9.35 IL4 IL5 MMP9 SELE TNF
3 vision/eye MP:0005391 9.02 SELE TNF IL4 ITGB2 MMP9

Drugs & Therapeutics for Scleritis

Drugs for Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 4
2 beta-endorphin Phase 4
3 Hormone Antagonists Phase 4,Phase 2,Phase 1
4 Hormones Phase 4,Phase 2,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
6 Melanocyte-Stimulating Hormones Phase 4
7
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
8
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
9
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
10
Infliximab Approved Phase 2,Phase 1 170277-31-3
11
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
12
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
13
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
14
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
15
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
16
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
17 Autonomic Agents Phase 1, Phase 2
18 Nasal Decongestants Phase 1, Phase 2
19 Ophthalmic Solutions Phase 1, Phase 2
20 Peripheral Nervous System Agents Phase 1, Phase 2
21 Pharmaceutical Solutions Phase 1, Phase 2
22 Respiratory System Agents Phase 1, Phase 2
23 Tetrahydrozoline Phase 1, Phase 2
24 Vasoconstrictor Agents Phase 1, Phase 2
25 Immunosuppressive Agents Phase 1, Phase 2
26 Antirheumatic Agents Phase 1, Phase 2
27 Anti-Bacterial Agents Phase 1, Phase 2
28 Antibiotics, Antitubercular Phase 1, Phase 2
29 Antifungal Agents Phase 1, Phase 2
30 Anti-Infective Agents Phase 1, Phase 2
31 Anti-Inflammatory Agents Phase 2,Phase 1
32 Antineoplastic Agents, Hormonal Phase 2,Phase 1
33 Dermatologic Agents Phase 2,Phase 1
34 Gastrointestinal Agents Phase 2,Phase 1
35 glucocorticoids Phase 2,Phase 1
36 Alkylating Agents Phase 2
37
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
38 Antiemetics Phase 1
39 BB 1101 Phase 1
40 Dexamethasone 21-phosphate Phase 1
41 Dexamethasone acetate Phase 1 1177-87-3
42 HIV Protease Inhibitors Phase 1
43
protease inhibitors Phase 1
44
Adalimumab Approved 331731-18-1 16219006
45
Azathioprine Approved 446-86-6 2265
46
Etanercept Approved, Investigational 185243-69-0
47
Methylprednisolone Approved, Vet_approved 83-43-2 6741
48
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
49
Mycophenolic acid Approved 24280-93-1 446541
50
Prednisolone Approved, Vet_approved 50-24-8 5755

Interventional clinical trials:

(show all 19)

id Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2 Seawater eyedrops
3 Gevokizumab for Active Scleritis Completed NCT01835132 Phase 1, Phase 2
4 Sirolimus Injections for Autoimmune Scleritis Completed NCT01517074 Phase 1, Phase 2 Sirolimus
5 Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Completed NCT00415506 Phase 1, Phase 2 Rituximab
6 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
7 Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Completed NCT01059955 Phase 1 Dexamethasone Phosphate Ophthalmic Solution (EGP-437);Dexamethasone phosphate ophthalmic solution
8 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
9 Study Evaluating PSI-697 in Patients With Scleritis Terminated NCT00367692 Phase 1 PSI-697
10 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
11 Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Completed NCT01958567
12 Perichondrium Autograft in Refractory Necrotizing Scleritis Completed NCT02864823
13 Human Samples and Data Repository Completed NCT00539370
14 Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Completed NCT00116090
15 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
16 Influencing Factors in Uveitis Completed NCT00827086
17 Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome Recruiting NCT02715323
18 Uveitis/Intraocular Inflammatory Disease Biobank (iBank) Recruiting NCT02656381
19 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Enrolling by invitation NCT00357071

Search NIH Clinical Center for Scleritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: scleritis

Genetic Tests for Scleritis

Anatomical Context for Scleritis

MalaCards organs/tissues related to Scleritis:

39
Eye, Neutrophil, Thyroid, Testes, Bone, T Cells, Endothelial

Publications for Scleritis

Articles related to Scleritis:

(show top 50) (show all 630)
id Title Authors Year
1
Bilateral Posterior Scleritis Associated with Giant Cell Arteritis: A Case Report. ( 28914559 )
2017
2
Occult Fungal Scleritis. ( 28275602 )
2017
3
Management of Uveitis and Scleritis in Necrobiotic Xanthogranuloma. ( 28394239 )
2017
4
Successful treatment with tocilizumab for refractory scleritis associated with relapsing polychondritis. ( 28120637 )
2017
5
Ocular metastasis from breast carcinoma simulating anterior scleritis: a case report. ( 28844204 )
2017
6
Indocyanine green angiography in anterior scleritis. ( 28886929 )
2017
7
Three atypical manifestations of granulomatosis with polyangiitis: lateral medullary syndrome, anterior cheek mass and melting scleritis of eye. ( 28769139 )
2017
8
Conjunctival Necrosis Masquerading as Necrotizing Scleritis. ( 28910555 )
2017
9
Endophthalmitis associated with Purpureocillium lilacinum during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. ( 28429128 )
2017
10
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
11
Hypertrophic Pachymeningitis Accompanying Scleritis. ( 28794383 )
2017
12
Rituximab Induction and Maintenance Treatment in Patients with Scleritis and Granulomatosis with Polyangiitis (Wegener's). ( 28628344 )
2017
13
Anakinra in the Treatment of Patients with Refractory Scleritis: A Pilot Study. ( 28537473 )
2017
14
Ocular Pharmacology for Scleritis: Review of Treatment and a Practical Perspective. ( 28355124 )
2017
15
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
16
Pseudomonas Scleritis following Pterygium Excision. ( 28924436 )
2017
17
When an Easy Thing Goes Wrong: Foreign Body Induced Granuloma-Associated Scleritis Following Pterygium Surgery. ( 28512421 )
2017
18
An OCT Study of Anterior Nodular Episcleritis and Scleritis. ( 28348907 )
2017
19
Scleritis Associated with SAPHO Syndrome: A Case Report. ( 28060551 )
2017
20
IgG4-related disease as an emerging cause of scleritis. ( 28229544 )
2017
21
Severe Idiopathic Posterior Scleritis in a Patient with HIV. ( 28147399 )
2017
22
Uveitis Specialists and Rheumatologists Select Different Therapies for Idiopathic Non-necrotizing Anterior Scleritis. ( 27744531 )
2016
23
Rituximab in the Treatment of Refractory Noninfectious Scleritis. ( 27138731 )
2016
24
Mycobacterium abscessus scleritis after a Baerveldt glaucoma implant. ( 27552708 )
2016
25
Nodular Scleritis Associated with Herpes Zoster Virus: An Infectious and Immune-Mediated Process. ( 27298747 )
2016
26
Gevokizumab in the treatment of autoimmune, non-necrotizing, anterior scleritis: Results of a phase I/II clinical trial. ( 27663070 )
2016
27
Posterior scleritis presenting as conjunctivitis in a child. ( 27941114 )
2016
28
Rituximab in the Treatment of Refractory Noninfectious Scleritis. ( 27161988 )
2016
29
Aspergillus fumigatus Endophthalmitis with Necrotizing Scleritis following Pars Plana Vitrectomy. ( 27379189 )
2016
30
Scleritis with Devastating Consequences. ( 27772649 )
2016
31
Interleukin-22 serum levels are elevated in active scleritis. ( 27009382 )
2016
32
Trabecular Micro-Bypass Stent Use in Necrotizing Scleritis. ( 27977475 )
2016
33
Nodular Scleritis in Association with Panuveitis in BehAset's Disease. ( 28289688 )
2016
34
Management of necrotizing scleritis after pterygium surgery with rituximab. ( 27982218 )
2016
35
Scleritis associated with relapsing polychondritis. ( 26888976 )
2016
36
Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis. ( 26893583 )
2016
37
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
38
A Rare Patient With Orbital Apex Syndrome, Anterior Uveitis, and Necrotizing Scleritis Due to Herpes Zoster Ophthalmicus. ( 28005810 )
2016
39
CT and MR Imaging in the Diagnosis of Scleritis. ( 27444937 )
2016
40
Poststreptococcal syndrome presenting as posterior scleritis in a child. ( 28007653 )
2016
41
Rituximab in the Treatment of Refractory Noninfectious Scleritis. ( 26766304 )
2016
42
Clinical Profile of Patients with Necrotizing Scleritis in a Tertiary Eye Care Center in Southern India. ( 27762661 )
2016
43
Necrotizing scleritis after pterygium excision with fibrin glue-fixated conjunctival autograft in Behcet's disease. ( 27521677 )
2016
44
Local treatment for scleritis secondary to Wiskott-Aldrich syndrome. ( 26951873 )
2016
45
Bilateral Scleritis and Retinal Vasculitis in Microscopic Polyangiitis. ( 27871395 )
2016
46
Invasive Ocular Surface Squamous Neoplasia Masquerading as Nodular Scleritis. ( 27262144 )
2016
47
Clinical Features and Complications of Scleritis in Chinese Patients. ( 27849414 )
2016
48
Latent tuberculosis-related scleritis: a case report. ( 27646473 )
2016
49
Diagnosis and management of non-infectious immune-mediated scleritis: current status and future prospects. ( 27055583 )
2016
50
Surgical treatment of peripheral ulcerative keratitis and necrotizing scleritis in granulomatosis with polyangiitis. ( 26837405 )
2016

Variations for Scleritis

Expression for Scleritis

Search GEO for disease gene expression data for Scleritis.

Pathways for Scleritis

Pathways related to Scleritis according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCL2 IL22 IL4 IL5 ITGB2 MMP9
2
Show member pathways
13.64 CCL2 IL22 IL4 IL5 ITGB2 TNF
3
Show member pathways
13.35 CCL2 IL22 IL4 IL5 ITGB2 TNF
4
Show member pathways
13.21 CCL2 IL22 IL4 IL5 ITGB2 TNF
5
Show member pathways
13.12 CCL2 IL22 IL4 IL5 TNF
6
Show member pathways
13.11 CCL2 IL22 IL4 IL5 ITGB2 MMP9
7
Show member pathways
12.73 CCL2 MMP9 SELE TNF
8
Show member pathways
12.67 IL22 IL4 IL5 ITGB2 TNF
9
Show member pathways
12.46 IL22 IL4 IL5 TNF
10 12.39 CCL2 IL4 ITGB2 TNF
11
Show member pathways
12.36 IL4 ITGB2 TNF
12
Show member pathways
12.28 IL4 IL5 TNF
13
Show member pathways
12.12 IL4 ITGB2 TNF
14
Show member pathways
12.1 CCL2 IL4 IL5 MMP9 TNF
15
Show member pathways
12.08 IL22 IL4 IL5
16
Show member pathways
12.03 IL4 IL5 TNF
17 11.95 CCL2 MMP9 SELE TNF
18 11.88 IL4 IL5 TNF
19 11.87 CCL2 IL4 MMP9 TNF
20 11.81 CCL2 MMP9 SELE TNF
21 11.8 CCL2 SELE TNF
22 11.79 IL4 IL5 TNF
23 11.74 CCL2 ITGB2 TNF
24 11.69 IL4 IL5 SELE
25
Show member pathways
11.65 IL4 IL5 TNF
26 11.64 IL22 IL4 IL5 TNF
27
Show member pathways
11.55 MMP9 SELE TNF
28 11.55 IL4 IL5 ITGB2 TNF
29 11.43 CCL2 IL4 TNF
30 11.42 ITGB2 MMP9 TNF
31 11.41 CCL2 IL4 ITGB2 MMP9 TNF
32 11.4 CCL2 ITGB2 TNF
33 11.37 IL4 IL5
34 11.28 MMP9 SELE
35 11.25 CCL2 ITGB2 SELE TNF
36 11.23 SELE TNF
37 11.22 CCL2 MMP9
38 11.22 CCL2 MMP9
39 11.2 IL4 IL5
40 11.18 IL4 IL5 TNF
41 11.09 IL4 IL5
42 11.07 CCL2 MMP9
43 10.96 IL22 IL4 IL5 TNF
44 10.95 CCL2 IL22 IL4 IL5 TNF
45 10.86 CCL2 TNF
46 10.82 IL4 IL5
47 10.82 CCL2 IL4 IL5 MMP9 TNF

GO Terms for Scleritis

Cellular components related to Scleritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL2 IL22 IL4 IL5 MMP9 TNF
2 extracellular space GO:0005615 9.17 CCL2 IL22 IL4 IL5 MMP9 SELE
3 external side of plasma membrane GO:0009897 9.16 IL4 TNF

Biological processes related to Scleritis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CCL2 IL4 IL5 TNF
2 MAPK cascade GO:0000165 9.77 CCL2 IL5 TNF
3 extracellular matrix organization GO:0030198 9.72 ITGB2 MMP9 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.69 IL4 MMP9 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 ITGB2 TNF
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.61 IL4 IL5 TNF
7 positive regulation of B cell proliferation GO:0030890 9.6 IL4 IL5
8 protein kinase B signaling GO:0043491 9.58 CCL2 TNF
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 CCL2 TNF
10 endodermal cell differentiation GO:0035987 9.57 ITGB2 MMP9
11 response to tumor necrosis factor GO:0034612 9.56 CCL2 SELE
12 leukocyte cell-cell adhesion GO:0007159 9.54 ITGB2 SELE
13 response to glucocorticoid GO:0051384 9.54 CCL2 IL22 TNF
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 MMP9 TNF
15 leukocyte tethering or rolling GO:0050901 9.48 SELE TNF
16 positive regulation of podosome assembly GO:0071803 9.46 IL5 TNF
17 leukocyte migration GO:0050900 9.46 ITGB2 MMP9 SELE TNF
18 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IL4 TNF
19 positive regulation of mononuclear cell migration GO:0071677 9.32 IL4 TNF
20 cellular extravasation GO:0045123 9.26 ITGB2 TNF
21 leukocyte migration involved in inflammatory response GO:0002523 9.13 CCL2 ITGB2 SELE
22 inflammatory response GO:0006954 9.1 CCL2 IL22 IL5 ITGB2 SELE TNF

Molecular functions related to Scleritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IL22 IL4 IL5 TNF

Sources for Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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