MCID: SCL016
MIFTS: 76

Scleroderma malady

Genetic diseases, Rare diseases, Skin diseases, Nephrological diseases, Respiratory diseases, Bone diseases categories

Summaries for Scleroderma

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MedlinePlus:32 Scleroderma means hard skin. it is a group of diseases that cause abnormal growth of connective tissue. connective tissue is the material inside your body that gives your tissues their shape and helps keep them strong. in scleroderma, the tissue gets hard or thick. it can cause swelling or pain in your muscles and joints. symptoms of scleroderma include calcium deposits in connective tissues raynaud's phenomenon, a narrowing of blood vessels in the hands or feet swelling of the esophagus, the tube between your throat and stomach thick, tight skin on your fingers red spots on your hands and face no one knows what causes scleroderma. it is more common in women. it can be mild or severe. doctors diagnose scleroderma using your medical history, a physical exam, lab tests, and a skin biopsy. there is no cure, but various treatments can control symptoms and complications. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Scleroderma, also known as systemic scleroderma, is related to systemic scleroderma and localized scleroderma, and has symptoms including xerostomia, gingivitis and dry skin. An important gene associated with Scleroderma is XYLT2 (xylosyltransferase II), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The drugs chloroquine and chloroquine phosphate and the compounds amiloride and erythromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and testes, and related mouse phenotypes are craniofacial and renal/urinary system.

Disease Ontology:9 A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs.

NIH Rare Diseases:41 Scleroderma is a group of widespread connective tissue diseases that involve changes in the skin, blood vessels, muscles, and internal organs. there are two main types. localized scleroderma affects only the skin. systemic scleroderma affects the blood vessels and internal organs, as well as the skin. although the cause of scleroderma is unknown, it is believed to be related to an overproduction and accumulation of collagen which results when the immune system turns against the body (autoimmune reaction). there is no cure, but various treatments can relieve symptoms. last updated: 10/11/2010

Wikipedia:63 Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by... more...

Aliases & Classifications for Scleroderma

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Scleroderma, Aliases & Descriptions:

Name: Scleroderma 9 41 32 60
Systemic Scleroderma 60
 
Dermatosclerosis 9


Classifications:



Related Diseases for Scleroderma

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Diseases in the Scleroderma family:

Systemic Scleroderma Localized Scleroderma
Juvenile Scleroderma

Diseases related to Scleroderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1systemic scleroderma32.1CTGF, TOP1
2localized scleroderma31.9MMP1, IL2RA
3polymyositis31.3TTN, FBL
4glomerulonephritis30.6CTGF, CD40LG, TGFB1
5keloids30.5CTGF, MMP1, TGFB1
6sjogren's syndrome30.2CD40LG, IL2RA
7skin disease30.1CTGF, IL4, MMP1
8pulmonary fibrosis30.0FBL, TGFB1, MMP1, TOP1, COL1A1, CTGF
9connective tissue disease30.0FBN1, TGFB1, IL4, IL2RA, CD40LG
10arthritis29.9FBN1, TGFB1, MMP1, IL4, CTGF
11rheumatic disease29.7CD40LG, IL2RA, TOP1
12systemic lupus erythematosus29.7FBL, FBN1, IRF5, TOP1, IL4, IL2RA
13hepatitis c29.6TGFB1, MMP1, IL4, CD40LG
14rheumatoid arthritis29.3MMP1, IRF5, TOP1, IL4, IL2RA, CD40LG
15asthma29.3CTGF, IL2RA, IL4, TGFB1
16ulcerative colitis28.9IL2RA, IL4, MMP1
17linear scleroderma10.9
18diffuse scleroderma10.8
19sine scleroderma10.7
20limited scleroderma10.7
21lupus erythematosus10.6
22interstitial lung disease10.6
23pulmonary hypertension10.5
24fasciitis10.5
25eosinophilic fasciitis10.5
26diastolic heart failure10.5TTN
27mixed connective tissue disease10.5
28calcinosis10.5
29juvenile scleroderma10.5
30intervertebral disc disease10.4COL1A1
31dermatomyositis10.4
32aortic disease10.4FBN1
33esophagitis10.4
34endotheliitis10.4
35aortic aneurysm10.4FBN1
36vasculitis10.4
37ureteral disease10.4TGFB1, CTGF
38facial hemiatrophy10.4
39telangiectasis10.3FBN1, FBL
40pseudoxanthoma elasticum10.3XYLT2, FBN1
41melorheostosis10.3
42otosclerosis10.3TGFB1, COL1A1
43biliary atresia10.3TGFB1, CTGF
44crest syndrome10.3
45fibromatosis, gingival10.3TGFB1, MMP1
46reynolds syndrome10.3
47crescentic glomerulonephritis10.3
48myositis10.3
49hemophagocytic lymphohistiocytosis10.3IL2RA
50vitreoretinopathy, neovascular inflammatory10.2TGFB1, CTGF

Graphical network of the top 20 diseases related to Scleroderma:



Diseases related to scleroderma

Symptoms for Scleroderma

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HPO human phenotypes related to Scleroderma:

(show all 60)
id Description Frequency HPO Source Accession
1 xerostomia hallmark (90%) HP:0000217
2 gingivitis hallmark (90%) HP:0000230
3 dry skin hallmark (90%) HP:0000958
4 acrocyanosis hallmark (90%) HP:0001063
5 muscle weakness hallmark (90%) HP:0001324
6 arthritis hallmark (90%) HP:0001369
7 nausea and vomiting hallmark (90%) HP:0002017
8 restrictive lung disease hallmark (90%) HP:0002091
9 abnormality of the stomach hallmark (90%) HP:0002577
10 arthralgia hallmark (90%) HP:0002829
11 autoimmunity hallmark (90%) HP:0002960
12 myalgia hallmark (90%) HP:0003326
13 lack of skin elasticity hallmark (90%) HP:0100679
14 chest pain hallmark (90%) HP:0100749
15 gangrene hallmark (90%) HP:0100758
16 cheilitis hallmark (90%) HP:0100825
17 skin ulcer hallmark (90%) HP:0200042
18 recurrent urinary tract infections typical (50%) HP:0000010
19 nephropathy typical (50%) HP:0000112
20 decreased nerve conduction velocity typical (50%) HP:0000762
21 chondrocalcinosis typical (50%) HP:0000934
22 hyperkeratosis typical (50%) HP:0000962
23 urticaria typical (50%) HP:0001025
24 hypopigmented skin patches typical (50%) HP:0001053
25 coronary artery disease typical (50%) HP:0001677
26 abnormality of the pericardium typical (50%) HP:0001697
27 weight loss typical (50%) HP:0001824
28 malabsorption typical (50%) HP:0002024
29 abdominal pain typical (50%) HP:0002027
30 pulmonary fibrosis typical (50%) HP:0002206
31 bowel incontinence typical (50%) HP:0002607
32 abnormal pattern of respiration typical (50%) HP:0002793
33 cranial nerve paralysis typical (50%) HP:0006824
34 feeding difficulties in infancy typical (50%) HP:0008872
35 arrhythmia typical (50%) HP:0011675
36 abnormal tendon morphology typical (50%) HP:0100261
37 mucosal telangiectasiae typical (50%) HP:0100579
38 teleangiectasia of the skin typical (50%) HP:0100585
39 myositis typical (50%) HP:0100614
40 renal insufficiency occasional (7.5%) HP:0000083
41 narrow mouth occasional (7.5%) HP:0000160
42 gingival bleeding occasional (7.5%) HP:0000225
43 behavioral abnormality occasional (7.5%) HP:0000708
44 hematuria occasional (7.5%) HP:0000790
45 seizures occasional (7.5%) HP:0001250
46 cirrhosis occasional (7.5%) HP:0001394
47 congestive heart failure occasional (7.5%) HP:0001635
48 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
49 pulmonary hypertension occasional (7.5%) HP:0002092
50 pulmonary infiltrates occasional (7.5%) HP:0002113
51 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
52 memory impairment occasional (7.5%) HP:0002354
53 tracheoesophageal fistula occasional (7.5%) HP:0002575
54 osteomyelitis occasional (7.5%) HP:0002754
55 osteolysis occasional (7.5%) HP:0002797
56 amyotrophy occasional (7.5%) HP:0003202
57 peripheral neuropathy occasional (7.5%) HP:0009830
58 arrhythmia occasional (7.5%) HP:0011675
59 neoplasm of the lung occasional (7.5%) HP:0100526
60 erectile abnormalities occasional (7.5%) HP:0100639

Drugs & Therapeutics for Scleroderma

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Genetic Tests for Scleroderma

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Anatomical Context for Scleroderma

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MalaCards organs/tissues related to Scleroderma:

31
Skin, Lung, Testes, Endothelial, Heart, Brain, T cells, Breast, Kidney, Bone, Colon, Liver, Thyroid, Monocytes, Bone marrow, Eye, Spinal cord, Small intestine, Spleen, Thymus, Cerebellum, Smooth muscle, Skeletal muscle, B cells

Animal Models for Scleroderma or affiliated genes

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Publications for Scleroderma

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Articles related to Scleroderma:

(show top 50)    (show all 1696)
idTitleAuthorsYear
1
Evaluation of right ventricular function performed by 3d-echocardiography in scleroderma patients. (25829185)
2015
2
Presentation of acute central retinal vein occlusion in scleroderma. (25892936)
2015
3
Antiphospholipid antibodies in localized scleroderma: the potential role of screening tests for the detection of antiphospholipid syndrome. (25097470)
2014
4
microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma. (22965811)
2013
5
Scleroderma mimics. (22131103)
2012
6
Localized periodontal ligament space widening as the only presentation of scleroderma--reliability recheck. (22707333)
2012
7
Nodular scleroderma presenting as multiple spontaneous keloidal scars. (22583729)
2012
8
Effect of topical interferon-I^ gene therapy using gemini nanoparticles on pathophysiological markers of cutaneous scleroderma in Tsk/+ mice. (22071972)
2012
9
A convenient method for producing the bleomycin-induced mouse model of scleroderma by weekly injections using a methylcellulose gel. (21448642)
2012
10
Case of juvenile localized scleroderma with joint sclerosis and SjAPgren's syndrome in a child with precocious puberty. (21658114)
2011
11
Measures of systemic sclerosis (scleroderma): Health Assessment Questionnaire (HAQ) and Scleroderma HAQ (SHAQ), physician- and patient-rated global assessments, Symptom Burden Index (SBI), University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (UCLA SCTC GIT) 2.0, Baseline Dyspnea Index (BDI) and Transition Dyspnea Index (TDI) (Mahler's Index), Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR), and Raynaud's Condition Score (RCS). (22588774)
2011
12
Letter to the editor regarding JAPrg Christoph Prinz et al. "The Nessos shirt: did Herakles die from scleroderma?" in J Dtsch Dermatol Ges 2011; 9: 336-7. (21910264)
2011
13
Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. (20309867)
2010
14
A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients. (20603050)
2010
15
A rare case of frontal linear scleroderma (en coup de sabre) with intra-oral and dental involvement. (20339416)
2010
16
Physical burden of symptoms in patients with localized scleroderma and eosinophilic fasciitis. (18936410)
2008
17
Immunohistochemical characterization of the cellular infiltrate in localized scleroderma. (18412858)
2008
18
Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases. (17222220)
2007
19
Absence of cutaneous TNFalpha-producing CD4+ T cells and TNFalpha may allow for fibrosis rather than epithelial cytotoxicity in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. (17429441)
2007
20
Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. (16405610)
2006
21
A case of severe sclerodermatous chronic graft-versus-host disease: exposure to cement containing abundant silica may have been a relevant factor in scleroderma-like skin changes. (16043910)
2005
22
Calcinosis universalis in systemic sclerosis with limited scleroderma. (15789907)
2005
23
Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743. (12881530)
2003
24
Linear scleroderma en coup de sabre and brain calcification: is there a pathogenic relationship? (12508412)
2003
25
Evaluation of medium-dose UVA1 phototherapy in localized scleroderma with the cutometer and fast Fourier transform method. (14571073)
2003
26
Localized and systemic scleroderma show different histological responses to methotrexate therapy. (11276011)
2001
27
Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma. (10943881)
2000
28
Systemic sclerosis sine scleroderma: comment on the article by Poormoghim et al. (11083297)
2000
29
Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage. (9082943)
1997
30
Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma. (9091475)
1997
31
Systemic scleroderma associated with Graves' disease. (9037923)
1996
32
Treatment of severe forms of localized scleroderma with oral corticosteroids: follow-up study on 17 patients. (8179352)
1994
33
Borrelia burgdorferi and localized scleroderma. (7954205)
1994
34
Increased mitogenic activity of scleroderma serum: inhibitory effect of human recombinant interferon-gamma. (7826142)
1994
35
Eosinophilic fasciitis in children frequently progresses to scleroderma-like cutaneous fibrosis. (8441144)
1993
36
Connective tissue metabolism including cytokines in scleroderma. (1457283)
1992
37
Connective tissue metabolism including cytokines in scleroderma. (1772750)
1991
38
Circulating androgens in male patients suffering from systemic scleroderma. (1929551)
1991
39
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. (2308937)
1990
40
Association of scleroderma with a T cell antigen receptor gamma gene restriction fragment length polymorphism. (1970246)
1990
41
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma. (2117968)
1990
42
Treatment of localized scleroderma and lichen sclerosus with etretinate. (6203311)
1984
43
Activation of fibroblasts induced by mononuclear cells from patients with systemic scleroderma and inactivation by mitogen stimulation. (6840370)
1983
44
Transcutaneous electrical nerve stimulation and extensor splint in linear scleroderma knee contracture. (6972203)
1981
45
Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous 'mixed' or 'overlap' syndrome. (718182)
1978
46
Eosinophilic fasciitis: a scleroderma-like illness. (576278)
1977
47
Linear scleroderma with hemiatrophy: report of three cases associated with collagen-vascular disease. (5907143)
1966
48
Recurrent spontaneous pneumothorax in diffuse scleroderma. Report of a case. (5907810)
1966
49
Scleroderma associated with osteopoikilosis. (13486973)
1958
50
Dental characteristics associated with acrosclerosis and diffuse scleroderma. (13428493)
1957

Variations for Scleroderma

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Expression for genes affiliated with Scleroderma

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LifeMap Discovery
Genes differentially expressed in tissues of Scleroderma patients vs. healthy controls: 30 (show all 30)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1FDCSPfollicular dendritic cell secreted proteinNose+5.870.000
2MUC7mucin 7, secretedNose+5.430.001
3PIPprolactin-induced proteinNose+5.280.000
4STATHstatherinNose+5.170.000
5KRT14keratin 14Nose+4.900.000
6CRISP3cysteine-rich secretory protein 3Nose+4.460.007
7C6orf58chromosome 6 open reading frame 58Nose+4.300.002
8BPIFB2BPI fold containing family B, member 2Nose+4.260.002
9IGHMimmunoglobulin heavy constant muNose+4.220.000
10ZG16Bzymogen granule protein 16BNose+3.910.000
11LOC285628uncharacterized LOC285628Nose+3.850.000
12CXCL13chemokine (C-X-C motif) ligand 13Nose+3.840.001
13AZGP1alpha-2-glycoprotein 1, zinc-bindingNose+3.780.001
14TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Nose+3.700.000
15DSG3desmoglein 3Nose+3.650.000
16DMBT1deleted in malignant brain tumors 1Nose+3.650.003
17SLC26A4solute carrier family 26 (anion exchanger), member 4Nose+3.550.001
18PRB3proline-rich protein BstNI subfamily 3Nose+3.550.001
19LTFlactotransferrinNose+3.490.008
20NCAPGnon-SMC condensin I complex, subunit GNose+3.480.000
21DUOX2dual oxidase 2Nose+3.430.007
22MUC5Bmucin 5B, oligomeric mucus/gel-formingNose+3.410.000
23LPOlactoperoxidaseNose+3.310.003
24C15orf48chromosome 15 open reading frame 48Nose+3.290.001
25CXCL5chemokine (C-X-C motif) ligand 5Nose+3.200.001
26ODAModontogenic, ameloblast asssociatedNose+3.120.007
27IDO1indoleamine 2,3-dioxygenase 1Nose+3.110.011
28TFtransferrinNose+3.110.000
29CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Nose+3.110.003
30PRB4proline-rich protein BstNI subfamily 4Nose+3.090.005

Search GEO for disease gene expression data for Scleroderma.

Pathways for genes affiliated with Scleroderma

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Pathways related to Scleroderma according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TGFB1, IL2RA
29.9IL2RA, TGFB1
39.8IL4, TGFB1
49.8IL4, TGFB1
59.8IL4, TGFB1
69.8MMP1, TGFB1
79.8CD40LG, IL4
89.7TGFB1, IRF5, COL1A1
9
Show member pathways
9.5CD40LG, IL4, TGFB1
10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.5CD40LG, IL4, TGFB1
119.5IRF5, IL4, IL2RA
129.5IL4, COL1A1, CD40LG
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4IL4, IL2RA, CD40LG
14
Show member pathways
9.3COL1A1, IL2RA, TGFB1, FBN1
15
Show member pathways
9.3CTGF, IL2RA, IL4, TGFB1
16
Show member pathways
9.3CTGF, IL2RA, IL4, TGFB1
17
Show member pathways
9.2FBN1, TGFB1, MMP1, COL1A1
18
Show member pathways
9.2FBN1, TGFB1, MMP1, COL1A1
19
Show member pathways
9.2CD40LG, IL2RA, IL4, TGFB1
209.2CD40LG, COL1A1, IL2RA, IL4
21
Show member pathways
8.7CTGF, COL1A1, IL2RA, IL4, TGFB1, FBN1

Compounds for genes affiliated with Scleroderma

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Compounds related to Scleroderma according to GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1amiloride43 28 1211.9TGFB1, IL4, CTGF
2erythromycin43 2 49 1212.8TGFB1, IL2RA, CD40LG
3il 10439.8TGFB1, IL4, IL2RA
4okt3439.8IL4, IL2RA, CD40LG
5ivig439.7IL4, IL2RA, CD40LG
6mycophenolate mofetil43 49 1211.7MMP1, IL2RA, CD40LG
7glycosaminoglycan439.7XYLT2, COL1A1, MMP1, TGFB1
8procollagen439.7CTGF, COL1A1, MMP1, TGFB1
9betacarotene439.7IL2RA, MMP1, TGFB1
10rituximab43 49 1211.7CD40LG, IL2RA, TGFB1
11tgf beta1439.7FBN1, TGFB1, MMP1, CTGF
12infliximab43 49 1211.7IL2RA, IL4, MMP1
13ribavirin43 49 1211.6MMP1, IL4, CD40LG
14theophylline43 28 24 1212.6TGFB1, IL2RA, CD40LG
15neopterin439.6CD40LG, IL2RA, IL4
16pentoxifylline43 1210.6IL2RA, IL4, MMP1
17losartan43 49 28 1212.6CTGF, MMP1, TGFB1
18hyaluronic acid43 2410.6FBN1, TGFB1, MMP1, CD40LG
19ribonucleic acid439.5TGFB1, MMP1, COL1A1, CTGF
20alpha tocopherol439.5MMP1, IL4, IL2RA, CTGF
21calcitriol43 59 24 1212.4IL2RA, IL4, MMP1, TGFB1
22hydroxyproline43 24 1211.4FBN1, TGFB1, MMP1, COL1A1, CTGF
23uva 1439.4IL2RA, MMP1
24herbimycin a43 5910.4MMP1, IL4, IL2RA, CD40LG
25heparin43 28 24 1212.4FBN1, TOP1, IL2RA, CD40LG, CTGF
26sb 20358043 5910.4TGFB1, MMP1, IL4, CTGF
27thymidine43 2410.4TGFB1, IL4, IL2RA, COL1A1, CTGF
28pdtc439.3TGFB1, MMP1, IL4
29formaldehyde43 2410.3TGFB1, MMP1, TOP1, IL2RA, CD40LG
30ascorbic acid43 2410.3FBN1, MMP1, IL2RA, CD40LG
31vitamin d439.3COL1A1, IL2RA, TGFB1, FBN1
32doxorubicin43 49 1211.3TGFB1, MMP1, TOP1, IL2RA, CD40LG
33cycloheximide439.3TGFB1, MMP1, TOP1, IL4, CTGF
34n acetylcysteine439.2MMP1, IL4, IL2RA, CD40LG, CTGF
35aspirin43 49 28 2412.2TGFB1, MMP1, IL4, IL2RA, CD40LG
36rantes439.2TGFB1, MMP1, IL4, IL2RA, CD40LG
37indomethacin43 28 59 1212.2CD40LG, IL2RA, IL4, MMP1, TGFB1
38bleomycin43 1210.2CTGF, COL1A1, IL2RA, IL4, TOP1, TGFB1
39paraffin439.2CD40LG, IL2RA, IL4, MMP1, TGFB1
40actinomycin d439.1FBL, TGFB1, TOP1, IL4, CD40LG
41creatinine439.1TTN, TGFB1, MMP1, IL2RA, CD40LG, CTGF
42retinoic acid43 2410.0FBN1, TGFB1, MMP1, COL1A1, CD40LG, CTGF
43cyclosporin a43 28 5911.0TGFB1, MMP1, IL4, IL2RA, CD40LG, CTGF
44estrogen438.7FBN1, TGFB1, MMP1, IL2RA, COL1A1, CD40LG
45arginine438.7FBL, FBN1, IL4, IL2RA, COL1A1, CD40LG
46pge2438.7TGFB1, MMP1, IL4, IL2RA, COL1A1, CD40LG
47dexamethasone43 49 28 1211.7TGFB1, MMP1, IL4, IL2RA, COL1A1, CD40LG
48vegf438.5TGFB1, MMP1, IRF5, IL4, IL2RA, COL1A1
49cysteine438.4FBN1, TTN, MMP1, IL4, IL2RA, COL1A1
50serine438.2FBL, FBN1, TTN, TGFB1, MMP1, COL1A1

GO Terms for genes affiliated with Scleroderma

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Cellular components related to Scleroderma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4CD40LG, IL2RA, IL4
2nuclear exosome (RNase complex)GO:00001769.4EXOSC10, EXOSC9
3proteinaceous extracellular matrixGO:00055789.4CTGF, MMP1, TGFB1, FBN1
4exosome (RNase complex)GO:00001789.1EXOSC9, EXOSC10
5extracellular spaceGO:00056158.8FBN1, TGFB1, IL4, COL1A1, CD40LG, CTGF
6extracellular regionGO:00055768.7FBN1, TTN, TGFB1, MMP1, COL1A1, CTGF

Biological processes related to Scleroderma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of collagen biosynthetic processGO:003296710.1CTGF, TGFB1
2negative regulation of immune responseGO:005077710.1IL2RA, TGFB1
3positive regulation of T cell differentiationGO:004558210.0IL2RA, IL4
4response to estradiolGO:003235510.0CTGF, COL1A1, TGFB1
5positive regulation of epithelial to mesenchymal transitionGO:00107189.9COL1A1, TGFB1
6face morphogenesisGO:00603259.9COL1A1, TGFB1
7positive regulation of activated T cell proliferationGO:00421049.9IL4, IL2RA
8positive regulation of interleukin-12 productionGO:00327359.8CD40LG, IRF5
9nuclear polyadenylation-dependent rRNA catabolic processGO:00710359.7EXOSC9, EXOSC10
10platelet activationGO:00301689.7CD40LG, COL1A1, TGFB1, TTN
11nuclear mRNA surveillanceGO:00710289.7EXOSC10, EXOSC9
12extracellular matrix disassemblyGO:00226179.7FBN1, MMP1, COL1A1
13nuclear-transcribed mRNA catabolic processGO:00009569.7EXOSC9, EXOSC10
14negative regulation of T cell proliferationGO:00421309.6IL2RA, TGFB1
15extracellular matrix organizationGO:00301989.5FBN1, TGFB1, MMP1, COL1A1
16blood coagulationGO:00075969.5COL1A1, MMP1, TGFB1, TTN
17RNA phosphodiester bond hydrolysis, exonucleolyticGO:00905039.5EXOSC10, EXOSC9

Molecular functions related to Scleroderma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.6CTGF, IL4, TGFB1
2exoribonuclease activityGO:00045329.1EXOSC10, EXOSC9
3protein bindingGO:00055155.8CTGF, FBL, FBN1, TTN, TGFB1, IRF5

Products for genes affiliated with Scleroderma

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Sources for Scleroderma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet