Scleroderma malady

Disease Ontology: A rheumatic disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs.⁶

MalaCards: Scleroderma, also known as scleroderma nos (disorder), is related to systemic scleroderma and localized scleroderma. An important gene associated with Scleroderma is EXOSC9 (exosome component 9), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Immune System. The compounds glucose and budesonide have been mentioned in the context of this disorder. Affiliated tissues include thymus, small intestine and kidney, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

scleroderma 6 43 scleroderma nos (disorder) 6 scleroderma (disorder) 6

dermatosclerosis 6 scleroderma nos 6

Diseases related to scleroderma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 967)

id	Related Disease	Score	Top Affiliating Genes
1	systemic scleroderma	41.1	PDE4A, KITLG, SFTPD, SELE, SELP, VEGFA
2	localized scleroderma	36.0	CD36, MMP1, IL2RA, LOX, DCN
3	diffuse scleroderma	33.8	BMP6, ARPC2, FBL, TGFB1, KNG1
4	limited scleroderma	33.1	CENPA, CENPB, CENPC1, IL2, IL2RA, IFI16
5	connective tissue disease	31.5	SFTPD, BMP6, BMPR2, CENPB, CD36, FBL
6	systemic lupus erythematosus	30.7	VWF, SELE, VIP, VCAM1, BLK, CLU
7	graft versus host disease	30.4	IL10, IL13, IL1R1, IL1RAPL2, IL2, IL2RA
8	pulmonary hypertension	30.1	PIK3CG, PDE4A, VIP, BMPR2, TNC, EDN1
9	mixed connective tissue disease	30.1	PIK3C2A, BMPR2, CENPB, CD40LG, INS, IL6
10	keloids	29.6	PIK3CG, BMP6, CD36, MMP1, MMP13, FGF2
11	polymyositis	29.6	PIK3C2A, VWF, SFTPD, SELE, VEGFA, VCAM1
12	rheumatoid arthritis	29.5	IL1R1, IL1RN, HLA-DRB1, CRP, COMP, PRTN3
13	interstitial lung disease	29.4	SFTPD, BMP6, LBR, IL1A, IL1R1, IL1RAPL2
14	dna topoisomerase i	28.9	XRCC5, CD40LG, FGF2, IL1B, IL2RA, CASP3
15	arthritis	28.7	VIP, IL1A, IL1B, IL6, IL8, TNF
16	myositis	28.6	PIK3C2A, VCAM1, LMNA, CLU, CD36, INS
17	calcinosis	28.3	PIK3C2A, KITLG, LMNA, CENPB, MGP, FBN1
18	primary biliary cirrhosis	28.1	LBR, CENPB, CD58, CD79A, CD40LG, HSPG2
19	hepatitis	28.0	SELP, XDH, CD58, CDH5, IFNA1, IFNA2
20	crescentic glomerulonephritis	27.9	KITLG, VCAM1, BMP6, MPO, CD79A, CD36
21	reactive arthritis	27.3	MYB, CD79A, HLA-B, CRP, COMP, PRTN3
22	poems syndrome	27.3	VEGFA, CD36, IL1B, IL5, IL6, CCL3
23	werner syndrome	27.2	LMNA, XRCC5, INS, IL6, MAPK14, ICAM1
24	critical limb ischemia	27.2	VWF, SELE, VEGFA, FGF2, FGF4, IL6
25	vascular disease	27.1	VWF, SELE, SELP, VEGFA, VCAM1, BMP6
26	thrombocytopenia	26.9	PIK3C2A, KITLG, VWF, SELE, SELP, MYB
27	psoriatic arthritis	26.7	IL10, IL1B, IL1RAPL2, IL1RN, IL6, TNF
28	autoimmune hepatitis	26.5	BMP6, CD79A, CD40LG, IL10, IL1B, IL1RN
29	hemolytic-uremic syndrome	26.4	VWF, SELP, CLU, CD79A, CD40LG, INS
30	sjogren's syndrome	26.3	PIK3C2A, KITLG, KIR2DS2, KIR2DS1, KIR2DL2, SELE
31	dermatomyositis	26.3	PIK3C2A, VWF, SFTPD, SELE, VEGFA, VCAM1
32	glomerulonephritis	25.5	REN, KITLG, VWF, SELP, VEGFA, VCAM1
33	lupus erythematosus	24.3	PIK3C2A, PIK3CG, KIR2DS2, KIR2DS1, KIR2DL2, VWF
34	vasculitis	23.8	REN, VWF, SELE, SELP, VEGFA, VCAM1
35	pulmonary fibrosis	23.0	RETNLB, VWF, SFTPD, SELE, SERPINB3, VEGFA
36	fibrosis	22.7	PIK3CG, PDE4A, RELA, REN, RETNLB, KITLG
37	blindness	21.3	PIK3C2A, PIK3CG, PDE4A, REN, VWF, SELE
38	hypertension	21.1	PIK3C2A, PIK3CG, PDE4A, REN, RETNLB, VWF
39	hypoxia	19.6	PIK3C2A, PIK3CG, NDN, PDE4A, RELA, REN
40	ischemia	19.0	PIK3C2A, PIK3CG, PDE4A, RELA, REN, KITLG
41	carcinoma	18.6	PIK3C2A, PIK3CG, NDN, PDE4A, RELA, REN
42	hyperprolactinemia	14.6	SELE, SELP, VIP, INS, IL13, IL4
43	otosclerosis	14.5	CD36, IL6, SP1, COL1A1, COL1A2, ACE
44	ehlers-danlos syndrome	14.4	CD36, FBN1, LOX, TNC, PLOD2, COL1A1
45	iga glomerulonephritis	14.4	SELE, BMP6, LBR, CD79A, CD40LG, MIF
46	hypersensitivity reaction type iv disease	14.4	SELE, LBR, MIF, IL2, IL4, IFNG
47	osteogenesis imperfecta	14.4	CD36, LOX, TNC, SPARC, PLOD2, COL1A1
48	gamma chain deficiency	14.4	KITLG, IL13, IL2, IL2RA, IL4, IL4R
49	telangiectasis	14.3	BMP6, BMPR2, CENPB, FBL, FBN1, SMAD4
50	cluster headache	14.3	SELE, VIP, VCAM1, CD40LG, INS, IL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to scleroderma:

²²

MGI Mouse Phenotypes related to scleroderma:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.2	NDN, SFTPD, SELP, NAB2, BMPR2, MGP
2	endocrine/exocrine gland phenotype	MP:0005379	11.0	SERPINE2, XDH, CENPB, CD40LG, IL2, IFNG
3	craniofacial phenotype	MP:0005382	10.8	KITLG, LBR, LAMP2, CENPA, CDH5, FBN1
4	embryogenesis phenotype	MP:0005380	10.5	MYB, MYBL2, BMPR2, UBC, CENPA, CENPC1
5	hematopoietic system phenotype	MP:0005397	10.5	SERPINB2, BLK, BCL2L11, ZBTB7B, BANK1, XRCC5
6	immune system phenotype	MP:0005387	9.7	PDE4A, REN, RETNLB, VWF, SELP, SERPINE2
7	liver/biliary system phenotype	MP:0005370	9.6	VEGFA, MYB, XYLT2, CD36, CD19, FLI1
8	normal phenotype	MP:0002873	9.6	NDN, RELA, REN, SELE, VIP, NAB2
9	behavior/neurological phenotype	MP:0005386	9.5	NDN, REN, SELE, SELP, SERPINE2, VIP
10	nervous system phenotype	MP:0003631	9.1	NDN, PDE4A, RELA, REN, KITLG, VWF
11	renal/urinary system phenotype	MP:0005367	9.0	REN, SELP, LMNA, CLU, BCL2L11, XYLT2
12	no phenotypic analysis	MP:0003012	9.0	NDN, SERPINE2, VEGFA, VCAM1, MYBL2, ZBTB7B
13	reproductive system phenotype	MP:0005389	9.0	REN, SERPINE2, VIP, NAB2, VEGFA, LMNA
14	limbs/digits/tail phenotype	MP:0005371	8.9	RELA, KITLG, VEGFA, LMNA, BCL2L11, LBR
15	integument phenotype	MP:0010771	8.9	PIK3CG, NDN, RELA, KITLG, SELP, NAB2
16	mortality/aging	MP:0010768	8.7	PIK3C2A, NDN, RELA, REN, RETNLB, KITLG
17	digestive/alimentary phenotype	MP:0005381	8.2	RETNLB, KITLG, VWF, VEGFA, LMNA, MUC1
18	growth/size phenotype	MP:0005378	7.9	PIK3C2A, PIK3CG, RELA, REN, KITLG, SFTPD
19	adipose tissue phenotype	MP:0005375	7.4	PIK3C2A, LMNA, LBR, XDH, CD36, INS
20	vision/eye phenotype	MP:0005391	7.0	RELA, KITLG, SELE, SELP, VEGFA, LMNA
21	skeleton phenotype	MP:0005390	6.7	PIK3CG, RELA, KITLG, NAB2, VEGFA, LMNA
22	tumorigenesis	MP:0002006	6.5	KITLG, MUC1, XRCC5, CD34, CD19, ITGAV
23	muscle phenotype	MP:0005369	5.6	PIK3CG, NDN, RELA, REN, SERPINB2, VEGFA
24	cellular phenotype	MP:0005384	5.5	PIK3CG, NDN, RELA, KITLG, VWF, SELE
25	cardiovascular system phenotype	MP:0005385	5.4	PIK3CG, PDE4A, RELA, REN, KITLG, VWF
26	homeostasis/metabolism phenotype	MP:0005376	5.2	PIK3C2A, PIK3CG, NDN, RELA, REN, RETNLB

Articles related to scleroderma:

(show top 50)    (show all 290)

id	Title	Authors	Year	Affiliating Genes
1	The p65 subunit of NF-I_B inhibits COL1A1 gene transcr iption in human dermal and scleroderma fibroblasts through its recruitment on p romoter by protein interaction with transcriptional activators (c-Krox, Sp1, an d Sp3). (22139845)	Beauchef G.... Galera P.	2012	COL1A1, NFKB1, RELA
2	A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients. (20603050)	Beretta L.... Scorza R.	2010	TGFB1, TNF, IL6
3	Analysis of transforming growth factor beta 1 (TGF-be ta1) gene polymorphisms in Turkish patients with scleroderma. (20517890)	BA1yA1k U.... Topal-Sarikaya A.	2010	TGFB1
4	Endothelial Fli1 deficiency impairs vascular homeosta sis: a role in scleroderma vasculopathy. (20228226)	Asano Y.... Trojanowska M.	2010	FLI1
5	Severe fibrotic changes and altered expression of ang iogenic factors in maternal scleroderma: placental findings. (19336420)	Ibba-Manneschi L.... Matucci-Cerinic M.	2010	CTGF
6	alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma? (19180474)	Kokot A.... BAPhm M.	2009	HMOX1, SOD2
7	Interferons and scleroderma-A new clue to understanding the pathogenesis of scleroderma? (18499269)	Coelho L.F.... Kroon E.G.	2008	IFNA1, ISG20
8	Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? (18197262)	Fleming J.N.... Schwartz S.M.	2008	CDH5
9	Scleroderma with crescentic glomerulonephritis: a case report. (18474117)	Ramaswami A.... Kafeel G.	2008	PRTN3
10	Absence of cutaneous TNFalpha-producing CD4+ T cells and TNFalpha may allow for fibrosis rather than epithelial cytotoxicity in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. (17429441)	Askew D.... Gilliam A.C.	2007	TNF
11	Immunization with DNA topoisomerase I induces autoimmune responses but not scleroderma-like pathologies in mice. (17937466)	Hu P.Q.... Oppenheim J.J.	2007	TOP1
12	Clinical significance of serum matrix metalloproteinase-13 levels in patients with localized scleroderma. (16956429)	Asano Y.... Tamaki K.	2006	MMP13
13	Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts. (16098034)	Ihn H.... Tamaki K.	2005	MAPK14, CD36
14	Mast cell accumulation and cytokine expression in the tight skin mouse model of scleroderma. (15810888)	Wang H.W.... McNeil H.P.	2005	KITLG
15	Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and SjAPgren's syndrome. (15059267)	Skoumal M.... Dunky A.	2004	COMP
16	Scleroderma fibroblasts constitutively express the long pentraxin PTX3. (15344601)	Luchetti M.M.... Gabrielli A.	2004	PTX3
17	Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma. (12920362)	Hasegawa M.... Takehara K.	2003	IL13
18	Treatment of scleroderma: an update. (12605568)	Sule S.D.... Wigley F.M.	2003	EDN1
19	Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. (12905481)	Luzina I.G.... White B.	2003	OSM
20	Treatment of scleroderma. (11790173)	Sapadin A.N.... Fleischmajer R.	2002	IFNG
21	Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. (11884483)	Zhang Y.... Gilliam A.C.	2002	TGFB1, TGFB3, TGFB2
22	Evaluation and management of pulmonary fibrosis in scleroderma. (11890875)	White B.	2002	CCL2, IL6R, CCL3
23	Increased circulating concentrations of the counteradhesive proteins SPARC and thrombospondin-1 in systemic sclerosis (scleroderma). Relationship to platelet and endothelial cell activation. (12465153)	Macko R.F.... Goldblum S.E.	2002	THBS1
24	Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations. (12415595)	Morse J.... Knowles J.	2002	BMPR2
25	Animal models for scleroderma: an update. (11890881)	Zhang Y.... Gilliam A.C.	2002	ITGA1
26	Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. (11710721)	Sambo P.... Gabrielli A.	2001	TNF, IL6, IL2
27	Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. (11739535)	Zhou X.... Arnett F.C.	2001	FBL
28	Depletion of protein kinase Cepsilon in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression. (11407697)	Tourkina E.... Ludwicka-Bradley A.	2001	TNC
29	Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. (11263781)	Povey A.... Silman A.J.	2001	CYP2E1, CYP2C19, CYP2A
30	Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). (11299058)	Scheja A.... Vischer U.M.	2001	VWF
31	CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. (11152469)	Holmes A.... Leask A.	2001	CTGF
32	Small nucleolar RNP scleroderma autoantigens associate with phosphorylated serine/arginine splicing factors during apoptosis. (10857791)	Overzet K.... Utz P.J.	2000	FBL, SRSF5
33	MHC class II associations with autoantibody and T cell immune responses to the scleroderma autoantigen topoisomerase I. (11090244)	Rands A.L.... McHugh N.J.	2000	TOP1
34	Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma. (10468187)	Querfeld C.... Sollberg S.	1999	TGFB1
35	Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteen-week, randomized, parallel-group, controlled trial. (10616013)	Dziadzio M.... Black C.M.	1999	AGTR1
36	A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma. (10207170)	Strehlow D.... Korn J.H.	1999	SERPINE2
37	Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts. (9540985)	Mattila L.... Kahari V.M.	1998	TIMP2, TIMP1, BMP6
38	Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P. (9037013)	Eder P.S.... Altman S.	1997	RPP30, RPP38
39	c-myb proto-oncogene is expressed by quiescent scleroderma fibroblasts and, unlike B-myb gene, does not correlate with proliferation. (8752671)	Piccinini G.... Gabrielli A.	1996	MYB, MYBL2
40	IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts. (8941674)	Makhluf H.A.... Trojanowska M.	1996	TNC, IL4
41	Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. (8991985)	Ludwicka A.... Silver R.M.	1995	TGFB1
42	Anti-CENP-B response in sera of uranium miners expose d to quartz dust and patients with possible development of systemic sclerosis ( scleroderma). (7562760)	Conrad K.... Frank K.H.	1995	CENPB
43	Stimulated expression of decorin and the decorin gene in fibroblasts cultured from patients with localized scleroderma. (7625849)	Izumi T.... Nishikawa T.	1995	DCN
44	Increased mitogenic activity of scleroderma serum: inhibitory effect of human recombinant interferon-gamma. (7826142)	Bryckaert M.... Tobelem G.	1994	IFNG
45	Effects of tumor necrosis factor-alpha on connective tissue metabolism in normal and scleroderma fibroblast cultures. (8466280)	Takeda K.... Ueki H.	1993	CD36
46	Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus. (7687701)	Carson C.W.... Newman W.	1993	SELE
47	Cell surface expression of lysosome-associated membrane proteins (LAMPs) in scleroderma: relationship of lamp2 to disease duration, anti-Sc170 antibodies, serum interleukin-8, and soluble interleukin-2 receptor levels. (8443983)	Holcombe R.F.... Wolf R.E.	1993	LAMP2
48	Cloning and characterization of the cDNA coding for a polymyositis- scleroderma overlap syndrome-related nucleolar 100-kD protein. (1383382)	Bluethner M.... Bautz F.A.	1992	EXOSC10
49	Prevalence and characteristics of anti-single-stranded DNA antibodies in localized scleroderma. Comparison with systemic lupus erythematosus. (1863075)	Ruffatti A.... Todesco S.	1991	CD40LG
50	HLA in systemic scleroderma (PSS) and familial scleroderma. (2050902)	Sasaki T.... Nakajima H.	1991	HSPG2

Genes related to scleroderma according to GeneCards:

(show top 50)    (show all 256)

id	Symbol	Description	Score	GeneCards Section Context
1	EXOSC9	exosome component 9	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
2	FBL	fibrillarin	11.1	Aliases & Descriptions, Publications, Summaries
3	SSSCA1	Sjogren syndrome/scleroderma autoantigen 1	11.1	Aliases & Descriptions, Orthologs, Transcripts, Summaries
4	EXOSC10	exosome component 10	11.1	Aliases & Descriptions, Publications, Orthologs
5	UBE4A	ubiquitination factor E4A	11.0	Summaries, Publications
6	TEX101	testis expressed 101	11.0	Aliases & Descriptions
7	XYLT2	xylosyltransferase II	11.0	Summaries
8	TTN	titin	11.0	Summaries
9	CTGF	connective tissue growth factor	11.0	Publications
10	TGFB1	transforming growth factor, beta 1	11.0	Publications
11	CENPB	centromere protein B, 80kDa	11.0	Publications
12	CENPA	centromere protein A	11.0
13	CENPC1	centromere protein C 1	11.0	Publications
14	FBN1	fibrillin 1	11.0	Publications
15	BMP6	bone morphogenetic protein 6	11.0	Publications
16	TOP1	topoisomerase (DNA) I	11.0	Publications
17	CD40LG	CD40 ligand	11.0	Publications
18	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
19	IL4	interleukin 4	11.0	Publications
20	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
21	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
22	FBLL1	fibrillarin-like 1	11.0
23	NM	neutrophil migration	11.0	Publications
24	ZBTB7B	zinc finger and BTB domain containing 7B	11.0	Publications
25	APITD1	apoptosis-inducing, TAF9-like domain 1	11.0
26	SKOR1	SKI family transcriptional corepressor 1	11.0	Publications
27	RPP30	ribonuclease P/MRP 30kDa subunit	11.0	UniProt Related, Publications
28	HOXD13	homeobox D13	11.0	Publications
29	TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	11.0
30	DEFB103B	defensin, beta 103B	11.0	Publications
31	HARS	histidyl-tRNA synthetase	11.0
32	COL1A2	collagen, type I, alpha 2	11.0	Publications
33	DEFB1	defensin, beta 1	11.0	Publications
34	PYHIN1	pyrin and HIN domain family, member 1	11.0
35	FAM167A	family with sequence similarity 167, member A	11.0
36	UBTF	upstream binding transcription factor, RNA polymerase I	11.0
37	IFI16	interferon, gamma-inducible protein 16	11.0
38	COL1A1	collagen, type I, alpha 1	11.0	Publications
39	SFTPD	surfactant protein D	11.0	Publications
40	SMAD7	SMAD family member 7	11.0	Publications
41	POLR3K	polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa	11.0
42	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
43	DCN	decorin	11.0	Publications
44	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	11.0	Publications
45	DEFB4A	defensin, beta 4A	11.0	Publications
46	EDNRA	endothelin receptor type A	11.0	Publications
47	ITGB5	integrin, beta 5	11.0	Publications
48	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
49	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
50	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications

Pathways related to scleroderma according to GeneDecks:

(show top 50)    (show all 190)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	11.1	ITGAV, ITGB5, FGF4, IL2, CTGF, LTBP1
2	Immune System38	10.6	KIR2DS2, KIR2DS1, KIR2DL2, VCAM1, BLK, CD79A
3	Transendothelial Migration of Leukocytes36	10.5	VCAM1, CDH5, ITGA1, ITGA2, ITGA5, ITGAV
4	Glioma Invasiveness36	10.5	KITLG, BMP6, ITGA1, ITGA5, ITGAV, ITGB2
5	RAR-Gamma-RXR-Alpha Degradation36	10.5	UBC, IL12A, IL16, IL2, MAPK14, CCL3
6	Jak-STAT signaling pathway20	10.2	PIK3CG, IL10, IL12A, IL13, IL2, IL2RA
7	TGF-beta signaling pathway20	10.0	BMP6, BMPR2, IFNG, TNF, SP1, SMAD3
8	IL-6 Pathway36	10.0	BMP6, IL10, IL12A, IL16, IL4, IL5
9	ERK5 Signaling36	9.9	KITLG, BMP6, FOXO3, FGF4, IL2, IL2RA
10	Amoebiasis20	9.9	RELA, SERPINB3, SERPINB2, ITGB2, IL12A, IL1B
11	Endothelin-1 Signaling Pathway36	9.8	BMP6, IL10, IL12A, IL13, IL16, IL1A
12	mTOR Pathway36	9.7	KITLG, BMP6, INS, FGF2, FGF4, IL2
13	14-3-3 Induced Intracellular Signaling36	9.7	KITLG, FGF2, FGF4, MAPK14, AKT1, TNF
14	Rho Family GTPases36	9.6	KITLG, BMP6, CDH5, ITGA1, ITGA2, ITGA5
15	Cytokine Network36	9.6	IL10, IL12A, IL13, IL16, IL1A, IL1B
16	STAT3 Pathway36	9.6	BMP6, BMPR2, IL10, IL12A, IL13, IL16
17	Glucocorticoid Receptor Signaling36	9.6	BMP6, IL10, IL12A, IL13, IL16, IL1A
18	all-trans-Retinoic Acid Signaling in Brain36	9.5	BMP6, IL10, IL12A, IL13, IL16, IL1A
19	Ras Pathway36	9.5	ITGA1, ITGA2, ITGA5, ITGAV, ITGB5, ARHGEF1
20	PTEN Pathway36	9.5	KITLG, ITGA1, ITGA2, ITGB2, FGF2, FGF4
21	eIF2 Pathway36	9.5	KITLG, BMP6, INS, FGF2, FGF4, IL2
22	Activation of PKC through GPCR36	9.5	KITLG, BMP6, ARHGEF1, FGF2, FGF4, IL2
23	Hematopoietic cell lineage20	9.4	KITLG, CD36, CD8A, CD34, CD19, ITGA1
24	Paxillin Interactions36	9.4	KITLG, ITGA1, ITGA2, ITGA5, ITGAV, ITGB2
25	p70S6K Signaling36	9.3	KITLG, BMP6, CD19, INS, FGF2, FGF4
26	Rap1 Pathway36	9.3	KITLG, BMP6, ITGA1, ITGA2, ITGA5, ITGAV
27	Akt Signaling36	9.3	PIK3CG, BMPR2, ITGA1, ITGA2, ITGB2, ITGB5
28	Telomerase Components in Cell Signaling36	9.3	KITLG, BMP6, FGF2, FGF4, IL2, AKT1
29	Rac1 Pathway36	9.2	KITLG, BMP6, ITGA1, ITGA2, ITGA5, ITGAV
30	MIF Mediated Glucocorticoid Regulation36	9.1	BMP6, MIF, IL10, IL12A, IL13, IL16
31	MIF Regulation of Innate Immune Cells36	9.1	BMP6, MIF, IL10, IL12A, IL13, IL16
32	Rheumatoid arthritis20	9.1	VEGFA, ITGB2, MMP1, IL1A, IL1B, IL6
33	Phospholipase-C Pathway36	9.1	KITLG, BMP6, CD79A, ITGA1, ITGA2, ITGA5
34	Focal adhesion20	9.1	PIK3CG, VWF, ITGA1, ITGA2, ITGA5, ITGAV
35	p53 Mediated Apoptosis36	9.1	KITLG, BMP6, FGF2, FGF4, IL2, IL2RA
36	DHA Signaling36	8.9	KITLG, BMP6, FGF2, FGF4, IL1B, IL2
37	ERK Signaling36	8.8	KITLG, BMP6, UBTF, ITGA1, ITGA5, ITGAV
38	PPAR Pathway36	8.7	KITLG, ITGA1, ITGA2, ITGA5, ITGAV, ITGB2
39	Pancreatic Adenocarcinoma36	8.7	KITLG, BMP6, MMP1, MMP13, ARHGEF1, FGF2
40	TGF-Beta Pathway36	8.6	KITLG, BMP6, FGF2, FGF4, IL10, IL12A
41	Apoptotic Pathways in Synovial Fibroblasts36	8.6	KITLG, BMP6, FGF2, FGF4, IL2, IL2RA
42	GPCR Pathway36	8.5	KITLG, BMP6, ARHGEF1, FGF2, FGF4, IL2
43	NFAT in Immune Response36	8.2	KITLG, BMP6, CD79A, FGF2, FGF4, IL2
44	TGF-beta Signaling Pathways37	8.1	PIK3CG, RELA, FOXO3, MAPK14, AKT1, ESR1
45	Chagas disease (American trypanosomiasis)20	8.1	PIK3CG, RELA, IL10, IL12A, IL1B, IL2
46	Estrogen Pathway36	8.1	KITLG, BMP6, FGF2, FGF4, IL2, IL6
47	Antioxidant Action of Vitamin-C36	8.0	KITLG, BMP6, BMPR2, FGF2, FGF4, IL10
48	Leishmaniasis20	7.8	RELA, ITGB2, IL10, IL12A, IL1A, IL1B
49	NF-KappaB Family Pathway36	7.2	RELA, KITLG, BMP6, BLK, FGF2, FGF4
50	NF-KappaB (p50-p65) Pathway36	7.1	RELA, KITLG, BMP6, UBC, FGF2, FGF4

Compounds related to scleroderma according to GeneDecks:

(show top 50)    (show all 458)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	PDE4A, CDH5, ITGA2, MIF, LOX, IFNA2
2	budesonide32 42 9 9	13.8	PDE4A, KITLG, SFTPD, CD36, F2RL1, RNASE3
3	ascorbic acid32 18	11.7	PIK3CG, SERPINB2, CD36, CD40LG, MMP13, IL1A
4	pravastatin32 34 9 18 9	14.7	PIK3C2A, SELE, SELP, IL6, CCL2, CTGF
5	lysine32	10.6	RELA, SERPINB2, MYB, CD58, MGP, FBN1
6	dopamine32 9 18 9	13.6	PDE4A, REN, SELE, VIP, BMP6, CLU
7	sodium nitroprusside32	10.4	PIK3C2A, PDE4A, REN, VWF, VIP, MYB
8	candesartan32 9 9	12.3	REN, SELP, VEGFA, MMP1, CCL2, PPARG
9	calcitriol32 42 9 18 9	14.2	REN, KITLG, BMP6, CLU, CD36, MGP
10	sp 60012532 42	11.2	PIK3CG, VCAM1, MMP1, MMP13, IL13, CASP3
11	isoproterenol32 9 9	12.2	PDE4A, LBR, CDH5, FGF2, IL13, IL1A
12	polyethylene glycol32	10.1	KITLG, SELE, VIP, MUC1, MPO, IFNA2
13	calcium32 9 18 9	13.1	PIK3C2A, PDE4A, RELA, REN, KITLG, VWF
14	estradiol32 9 18 9	13.0	REN, KITLG, MYB, MUC1, CDH5, MMP13
15	okt332	10.0	SELE, VCAM1, BMP6, LBR, CD79A, CD40LG
16	polysaccharide32	9.7	KITLG, SFTPD, SELE, SELP, SERPINE2, VCAM1
17	mip 1alpha32	9.6	IL10, IL13, IL1B, IL4, IL6, IL8
18	cholesterol32 9 18 9	12.5	PIK3C2A, REN, KITLG, VWF, SFTPD, SELE
19	tacrolimus32 34 9 9	12.5	REN, BMP6, CD79A, CD36, INS, IL10
20	chloramphenicol32 9 9	11.5	SELE, MYB, MYBL2, MUC1, LBR, MPO
21	oxygen32 18	10.5	PIK3C2A, KITLG, SFTPD, MYB, CLU, BCL2L11
22	n acetylcysteine32	9.4	VWF, SELE, SELP, VCAM1, CLU, CD79A
23	arginine32	9.4	PIK3C2A, PDE4A, REN, VWF, VIP, MYB
24	tetracycline32 9 9	11.2	VWF, CD40LG, MMP1, MMP13, MIF, FGF2
25	atorvastatin32 34 9 18 9	13.2	PIK3C2A, VWF, SELE, SELP, VEGFA, VCAM1
26	12-o-tetradecanoylphorbol 13-acetate32	9.1	SERPINB2, BMP6, LBR, CD34, ITGA2, ITGB2
27	matrigel32	9.1	PIK3CG, VWF, SELE, SERPINB2, VEGFA, VCAM1
28	nitric oxide32 9 18 9	12.1	PDE4A, REN, KITLG, SFTPD, SELE, SELP
29	neopterin32	9.1	LBR, CD79A, CD40LG, IL10, IL1A, IL1B
30	rottlerin32 42	9.9	PIK3CG, VCAM1, CD36, CD40LG, IL6R, IL8
31	simvastatin32 34 42 9 18 9	13.9	PIK3C2A, KITLG, VWF, SELE, SELP, VEGFA
32	estrogen32	8.9	VWF, SERPINB2, VIP, CLU, CD36, CD34
33	vitamin d32	8.8	BMP6, CLU, LBR, CD79A, CD36, ITGB2
34	histamine32 18	9.7	PDE4A, KITLG, VWF, SFTPD, SELE, SELP
35	adenylate32	8.5	PIK3CG, PDE4A, KITLG, VWF, SELE, SELP
36	cytochalasin d32 42	9.5	PIK3CG, KITLG, VWF, SELE, VCAM1, CD36
37	lactate32	8.5	PIK3C2A, KITLG, VWF, SFTPD, SELE, SELP
38	prostacyclin32	8.4	PIK3C2A, PDE4A, REN, VWF, SELE, SELP
39	troglitazone32 42 9 9	11.3	PIK3CG, SELE, VCAM1, BMP6, CD36, MMP1
40	lipid32	8.3	PIK3C2A, PIK3CG, PDE4A, KITLG, SFTPD, SELE
41	butyrate32	8.2	KITLG, MYB, BMP6, CLU, MUC1, MPO
42	ndga32	8.2	VCAM1, MMP13, IL1B, IL2RA, LOX, HSPG2
43	mg 13232 42	9.0	PIK3CG, BCL2L11, IL1A, IL1B, IL8, MAPK14
44	doxorubicin32 34 9 9	10.8	PIK3C2A, PIK3CG, KITLG, SELE, MYB, BMP6
45	superoxide32 18	8.6	PIK3C2A, PDE4A, KITLG, SERPINB2, VCAM1, CLU
46	diphenyleneiodonium32	7.5	VEGFA, VCAM1, XDH, MPO, IL1B, IL1R1
47	5fluorouracil32	7.4	PIK3CG, KITLG, SELE, VEGFA, MUC1, MPO
48	actinomycin d32	6.5	PIK3CG, PDE4A, KITLG, SELE, SERPINE2, SERPINB2
49	genistein32 9 18 9	9.2	PIK3CG, KITLG, SELE, SELP, VEGFA, VCAM1
50	retinoic acid32 42 18	6.7	PIK3CG, NDN, PDE4A, KITLG, VWF, SELP

Cellular components related to scleroderma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	10.6	SOD1, PRTN3, DCN, TGFBI, TGFB3, TGFB2
2	proteinaceous extracellular matrix	GO:005578	10.4	CTGF, COMP, LTBP1, ELN, TGFB1, TGFBI
3	platelet alpha granule lumen	GO:031093	10.2	HGF, VWF, VEGFA, CLU, KNG1, TGFB3
4	neuronal cell body	GO:043025	10.2	ADA, ADORA2A, SOD1, TAC1, TGFB3, TGFB2
5	external side of plasma membrane	GO:009897	10.2	CD40LG, CD8A, CD36, CD79A, VCAM1, SELP
6	extracellular region	GO:005576	10.1	PRL, DCN, DEFB4A, DEFB1, TAC1, DPP4
7	cell surface	GO:009986	10.1	ACE2, ACVRL1, TLR3, TIMP2, THBD, TGFB1
8	extracellular space	GO:005615	9.1	NGF, IFNG, IFNA2, LOX, CCL5, CCL18
9	nucleoplasm	GO:005654	7.5	SKI, NFKB1, SMURF2, SMURF1, SMAD7, SMAD4
10	plasma membrane	GO:005886	7.4	CTGF, CTLA4, SMAD3, SMAD7, SMURF1, SMURF2
11	cytosol	GO:005829	7.2	COPB2, PLA2G4A, SMURF2, SMURF1, SMAD7, SMAD4

Biological processes related to scleroderma according to GeneDecks:

(show top 50)    (show all 71)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:050900	11.1	F2RL1, SRC, COL1A1, COL1A2, THBD, ROCK1
2	leukocyte cell-cell adhesion	GO:007159	11.0	ROCK1, ICAM1, CCL5, ITGB2, ITGA5, CD40LG
3	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	10.9	TGFBR2, TGFBR1, TGFB3, TGFB1, SKIL, SKI
4	transforming growth factor beta receptor signaling pathway	GO:007179	10.9	TGFBR2, PDGFB, SKI, SKIL, ACVRL1, TGFB1
5	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.8	IL6R, PDGFB, OSM, ADIPOQ, HGF, IL6
6	regulation of immune response	GO:050776	10.8	ITGB2, IL4, ICAM1, HLA-B, SMAD3, CD19
7	response to lipopolysaccharide	GO:032496	10.7	NGF, EDN1, EDNRA, THBD, TAC1, DCN
8	positive regulation of protein secretion	GO:050714	10.6	ADORA2A, TGFB3, TGFB2, TGFB1, IL13, BMP6
9	immune response	GO:006955	10.6	DEFB1, DEFB4A, OSM, CSF2, CSF3, THBS1
10	BMP signaling pathway	GO:030509	10.6	BMPR2, SMAD4, SMAD7, SMURF1, SMURF2, SKI
11	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.5	TGFBR2, THBS1, AGTR1, ACE2, PDGFRB, PDGFB
12	cell-cell signaling	GO:007267	10.5	CCL5, IFNA2, EDN1, TGFB2, TAC1, PGF
13	positive regulation of cell migration	GO:030335	10.5	PDGFB, PDGFRB, EDN1, EGFR, THBS1, TGFB1
14	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.5	HGF, TGFB2, PDGFRB, PDGFB, PTK2, CAT
15	platelet degranulation	GO:002576	10.4	EGF, TTN, TIMP1, THBS1, TGFB1, TGFB2
16	wound healing	GO:042060	10.4	DCN, TGFBR1, TGFB2, COL3A1, SMAD3, LOX
17	positive regulation of cell division	GO:051781	10.4	TGFB1, TGFB2, TGFB3, OSM, PGF, PDGFB
18	aging	GO:007568	10.4	TGFB1, TGFB2, TGFB3, DCN, ADA, TIMP3
19	regulation of blood pressure	GO:008217	10.3	ACE, ACVRL1, TAC1, SOD1, SOD2, EDNRB
20	cell proliferation	GO:008283	10.2	PTEN, SMAD4, SKI, EDNRA, EGFR, ELN
21	neutrophil chemotaxis	GO:030593	10.2	TGFB2, EDN1, IFNG, CCL3, CCL2, IL8
22	heart development	GO:007507	10.1	EDN1, EDNRA, TGFB2, TGFBR1, TGFBR2, EP300
23	interferon-gamma-mediated signaling pathway	GO:060333	10.1	PRKCD, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-B
24	positive regulation of smooth muscle cell proliferation	GO:048661	10.0	HIF1A, EDN1, PDGFRB, PDGFB, PTGS2, TNF
25	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.0	TNF, CTGF, PDGFB, PDGFRB, EDNRA, F2RL1
26	positive regulation of chemokine biosynthetic process	GO:045080	9.9	TLR3, TNF, HMOX1, IFNG, IL4, IL1B
27	positive regulation of endothelial cell proliferation	GO:001938	9.9	PGF, VEGFA, BMP6, BMPR2, FGF2, CCL2
28	platelet activation	GO:030168	9.8	PF4, PDGFB, EGF, TTN, TIMP1, THBS1
29	negative regulation of cell proliferation	GO:008285	9.7	SMAD4, SKI, ACVRL1, TIMP2, TGFB1, TGFB2
30	angiogenesis	GO:001525	9.7	PTK2, CTGF, EGF, ACVRL1, HIF1A, TGFB2
31	response to drug	GO:042493	9.6	PDGFB, EDN1, TOP1, THBS1, TGFB1, TGFB2
32	blood coagulation	GO:007596	9.5	HGF, ADORA2A, ADRA2C, KNG1, ITGA2, ITGA5
33	positive regulation of mitosis	GO:045840	9.5	EGF, EDN1, PDGFRB, PDGFB, TNF, IL1B
34	response to hypoxia	GO:001666	9.5	CAT, VEGFA, VCAM1, IL1A, IL1B, CCL2
35	positive regulation of cell proliferation	GO:008284	9.4	DPP4, OSM, PRTN3, CSF2, CSF3, PGF
36	positive regulation of MAP kinase activity	GO:043406	9.4	TGFB1, EGFR, EGF, EDN1, PDGFRB, PDGFB
37	protein kinase B signaling cascade	GO:043491	9.4	EP300, TGFB1, PTEN, TNF, AKT1, CCL5
38	cellular response to interleukin-1	GO:071347	9.2	HIF1A, EDN1, NFKB1, ICAM1, CCL5, CCL3
39	response to glucocorticoid stimulus	GO:051384	9.0	SPARC, PLA2G4A, NGF, ADIPOQ, EP300, PTGS2
40	positive regulation of nitric oxide biosynthetic process	GO:045429	8.7	EGFR, EDN1, PTX3, PTGS2, TNF, ESR1
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.5	CAT, TNF, NFKB1, TLR3, TGFB1, ICAM1
42	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.5	TNF, PTEN, PPARG, NGF, EP300, ESR1
43	cytokine-mediated signaling pathway	GO:019221	8.5	CSF3, PRKCD, STAT4, RELA, VCAM1, UBC
44	inflammatory response	GO:006954	8.0	PIK3CG, RELA, IL5, IL6, IL8, CCL2
45	innate immune response	GO:045087	8.0	F2RL1, PPARG, NFKB1, TLR3, DEFB1, DEFB4A
46	apoptotic process	GO:006915	8.0	PTEN, PTK2, COMP, NGF, NFKB1, C1D
47	positive regulation of transcription, DNA-dependent	GO:045893	7.9	SMAD4, COL1A1, NFKB1, PDGFB, EGF, EGR1
48	negative regulation of apoptotic process	GO:043066	7.9	XRCC5, ITGAV, MIF, INS, FGF4, IL1RN
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	IL1B, IL2, IL4, IL6, MAPK14, IFI16
50	anti-apoptosis	GO:006916	7.1	HMOX1, TNF, TERT, COMP, NGF, NFKB1

Molecular functions related to scleroderma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta binding	GO:050431	10.7	TGFBR2, TGFBR1, TGFB3, THBS1, ACVRL1, ITGAV
2	heparin binding	GO:008201	10.7	CTGF, COMP, PF4, THBS1, PGF, KNG1
3	collagen binding	GO:005518	10.5	COMP, PDGFB, DPP4, DCN, SMAD7, SMAD4
4	SMAD binding	GO:046332	10.4	TGFBR2, TGFBR1, ACVRL1, SKOR1, SKIL, SKI
5	integrin binding	GO:005178	10.3	TGFBI, THBS1, TIMP2, COL3A1, CTGF, SRC
6	receptor binding	GO:005102	9.8	TNC, TNFSF13B, SRC, PDGFRB, TGFB2, DPP4
7	growth factor activity	GO:008083	9.8	HGF, IL5, IL4, IL2, IL1B, IL12A
8	cytokine activity	GO:005125	9.7	BMP6, VEGFA, KITLG, ADIPOQ, IL2, IL1B
9	protein homodimerization activity	GO:042803	8.7	CRP, NFKB1, PDGFB, TGFB1, TGFB2, DPP4
10	enzyme binding	GO:019899	7.9	EGFR, HIF1A, TTN, TGFB1, PRKCD, PRTN3
11	protein binding	GO:005515	6.2	NUCB2, PRTN3, PRKCD, DPP4, TGFBR2, TGFBR1