MCID: SCL012
MIFTS: 32

Sclerosing Adenosis of Breast malady

Summaries for Sclerosing Adenosis of Breast

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MalaCards: Sclerosing Adenosis of Breast, also known as sclerosing breast adenosis, is related to leiomyoma and actinic keratosis. An important gene associated with Sclerosing Adenosis of Breast is MYC (v-myc avian myelocytomatosis viral oncogene homolog), and among its related pathways are Validated targets of C-MYC transcriptional repression and miRNAs involved in DDR. The compounds adriamycin and etoposide have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Sclerosing Adenosis of Breast

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

sclerosing adenosis of breast 8
sclerosing breast adenosis 8
breast sclerosing adenosis 60


External Ids:

Disease Ontology8 DOID:8310
NCIt39 C5205

Related Diseases for Sclerosing Adenosis of Breast

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17GeneCards, 18GeneDecks
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Diseases related to Sclerosing Adenosis of Breast via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyoma10.0MKI67
2actinic keratosis10.0TP53
3oral cancer10.0TP53
4thyroid cancer10.0TP53
5esophageal cancer10.0TP53
6leukoplakia10.0MKI67
7cervical squamous cell carcinoma10.0MKI67
8meningioma10.0MKI67
9ependymoma10.0MKI67
10leiomyosarcoma10.0TP53
11gastrointestinal stromal tumor10.0MKI67
12papilloma10.0TP53
13kidney cancer10.0TP53
14gastritis10.0TP53
15pituitary adenoma10.0MKI67
16oral cavity cancer10.0TP53
17benign meningioma10.0MKI67
18cerebral primitive neuroectodermal tumor10.0MYC
19rhabdomyosarcoma10.0TP53
20malignant glioma10.0TP53
21keratoacanthoma10.0MKI67
22smooth muscle tumor10.0MKI67
23ulcerative colitis10.0TP53
24uterine carcinosarcoma10.0ERBB2
25laryngeal benign neoplasm10.0TP53, MKI67
26laryngeal squamous cell carcinoma10.0TP53, MKI67
27anaplastic astrocytoma10.0TP53, MKI67
28astrocytoma10.0MKI67, TP53
29oligodendroglioma10.0TP53, MKI67
30bladder transitional cell carcinoma10.0MKI67, TP53
31sarcoma10.0TP53, MKI67
32osteosarcoma10.0TP53, MYC
33barrett's esophagus10.0TP53, MKI67
34cervical cancer10.0TP53, MYC
35adrenocortical carcinoma10.0TP53, MKI67
36biliary tract neoplasm10.0ERBB2
37li-fraumeni syndrome10.0ERBB2
38multiple myeloma10.0TP53
39basal cell carcinoma10.0MKI67, TP53
40ductal carcinoma in situ10.0TP53, ERBB2
41cholangiocarcinoma10.0TP53, ERBB2
42malignant mixed mullerian tumor10.0TP53, ERBB2
43breast fibroadenoma10.0ERBB2, MKI67
44pancreatic cancer10.0TP53, ERBB2
45endometrial carcinoma10.0ERBB2, TP53
46adenoid cystic carcinoma10.0ERBB2, MKI67
47male breast cancer10.0MYC, ERBB2
48bladder carcinoma in situ10.0ERBB2, TP53
49papillary carcinoma10.0ERBB2, MKI67
50b-cell lymphomas10.0TP53, MYC, MKI67

Graphical network of the top 20 diseases related to Sclerosing Adenosis of Breast:



Diseases related to sclerosing adenosis of breast

Clinical Features for Sclerosing Adenosis of Breast

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Drugs & Therapeutics for Sclerosing Adenosis of Breast

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sclerosing Adenosis of Breast

Drug clinical trials:

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Search NIH Clinical Center for Sclerosing Adenosis of Breast

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Genetic Tests for Sclerosing Adenosis of Breast

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Anatomical Context for Sclerosing Adenosis of Breast

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32MalaCards
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MalaCards organs/tissues related to Sclerosing Adenosis of Breast:

32
Breast

Animal Models for Sclerosing Adenosis of Breast or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sclerosing Adenosis of Breast:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5TP53, ERBB2, MYC

Publications for Sclerosing Adenosis of Breast

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50PubMed
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Articles related to Sclerosing Adenosis of Breast:

idTitleAuthorsYear
1
Ductal carcinoma in situ that involves sclerosing adenosis: high frequency of bilateral breast cancer occurrence. (23083502)
2012
2
Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast. (19790246)
2010
3
Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. (19383289)
2007
4
Expression of c-erbB2, p53, Bcl-2, Bax, c-myc and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. (12447674)
2002
5
C-myc oncoprotein expression and gene amplification in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. (14965711)
2002

Genetic Variations for Sclerosing Adenosis of Breast

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Expression for genes affiliated with Sclerosing Adenosis of Breast

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sclerosing Adenosis of Breast

Search GEO for disease gene expression data for Sclerosing Adenosis of Breast.

Pathways for genes affiliated with Sclerosing Adenosis of Breast

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 59Tocris Bioscience, 55SinoBiological, 49PharmGKB, 52R&D Systems
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Pathways related to Sclerosing Adenosis of Breast according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ERBB2, MYC
29.1MYC, TP53
3
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9.1TP53, MYC
49.1MYC, TP53
59.1TP53, MYC
69.1TP53, MYC
7
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9.1TP53, MYC
89.1TP53, MYC
99.1TP53, MYC
109.1TP53, MYC
11
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9.1TP53, MYC
129.1MYC, TP53
139.1MYC, TP53
149.1TP53, MYC
159.1TP53, MYC
169.1TP53, MYC
17
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9.0ERBB2, TP53
189.0ERBB2, TP53
19
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8.5TP53, ERBB2, MYC
20
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8.5MYC, ERBB2, TP53
21
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8.5MYC, ERBB2, TP53
22
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8.5TP53, ERBB2, MYC
238.5MYC, ERBB2, TP53
24
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8.5TP53, ERBB2, MYC
25
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8.5MYC, ERBB2, TP53
26
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8.5MYC, ERBB2, TP53
278.5TP53, ERBB2, MYC
288.5TP53, ERBB2, MYC
29
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8.5MYC, ERBB2, TP53
30
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8.5TP53, ERBB2, MYC
318.5TP53, ERBB2, MYC
32
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8.5TP53, ERBB2, MYC
338.5TP53, ERBB2, MYC

Compounds for genes affiliated with Sclerosing Adenosis of Breast

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Sclerosing Adenosis of Breast according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1adriamycin4410.4MYC
2etoposide44 49 59 1113.2ERBB2
3vincristine44 49 1111.9MYC, MKI67
4depsipeptide449.8TP53
5hrgbeta1449.7ERBB2, MYC
6everolimus49 44 1111.7MYC, ERBB2
7anastrozole44 1110.7ERBB2, MKI67
8fulvestrant44 49 28 1112.7MKI67, ERBB2
9vinorelbine44 1110.7ERBB2, MKI67
10letrozole44 49 59 1112.7MKI67, ERBB2
11tanshinone iia449.6MYC, TP53
1210-hydroxycamptothecin449.5MYC, TP53
13hmba449.5TP53, MYC
14cd 437449.4TP53, MYC
15aphidicolin449.4MYC, TP53
16sodium arsenite449.4MYC, TP53
17dutp449.4TP53, MKI67
18taxane449.3ERBB2, TP53
19celecoxib44 59 28 49 11 2414.3ERBB2, MKI67
20radicicol44 59 1111.3ERBB2, TP53
21roscovitine449.3TP53, MYC
22topotecan44 1110.2TP53, ERBB2
23folate449.2ERBB2, MYC, MKI67
24oxaliplatin44 49 1111.1TP53, ERBB2
25melphalan44 1110.0TP53, MYC
264-hydroxytamoxifen449.0ERBB2, MYC
27flavopiridol44 1110.0ERBB2, TP53
28paclitaxel44 49 1111.0TP53, ERBB2, MYC
29suberoylanilide hydroxamic acid449.0TP53, ERBB2, MYC
30n-(4-hydroxyphenyl)retinamide449.0MYC, ERBB2, TP53
31bortezomib44 119.9TP53, ERBB2, MYC
32irinotecan44 49 1110.9MKI67, ERBB2, TP53
33gemcitabine44 49 1110.9TP53, ERBB2, MYC
34thymidylate448.9MKI67, ERBB2, TP53
35docetaxel44 49 59 1111.9TP53, ERBB2, MYC
36cyclophosphamide44 49 1110.9TP53, ERBB2, MKI67
37curcumin448.9MYC, ERBB2, TP53
385fluorouracil448.9TP53, ERBB2, MKI67
39n acetylcysteine448.9TP53, ERBB2, MYC
40ly294002448.8MYC, ERBB2, TP53
41thymidine44 249.8TP53, MYC, MKI67
42progesterone44 59 28 11 2412.6TP53, ERBB2, MKI67
43tamoxifen44 49 28 1111.4TP53, ERBB2, MYC, MKI67
44doxorubicin44 49 1110.4MKI67, MYC, ERBB2, TP53
45paraffin448.4TP53, ERBB2, MYC, MKI67
46cisplatin44 49 59 1111.4MKI67, MYC, ERBB2, TP53
47cycloheximide448.4MKI67, MYC, ERBB2, TP53
48vegf448.4MKI67, MYC, ERBB2, TP53
49estrogen448.4TP53, ERBB2, MYC, MKI67
50serine448.3TP53, ERBB2, MYC, MKI67

GO Terms for genes affiliated with Sclerosing Adenosis of Breast

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16Gene Ontology
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Biological processes related to Sclerosing Adenosis of Breast according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:0506799.3ERBB2, MYC
2negative regulation of fibroblast proliferationGO:0481479.2TP53, MYC
3response to gamma radiationGO:0103329.2TP53, MYC
4cellular response to UVGO:0346449.0TP53, MYC
5cellular response to drugGO:0356908.8TP53, MYC
6cell proliferationGO:0082838.5MKI67, ERBB2, TP53

Products for genes affiliated with Sclerosing Adenosis of Breast

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Sources for Sclerosing Adenosis of Breast

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet