MCID: SCL009
MIFTS: 50

Sclerosing Cholangitis malady

Gastrointestinal diseases, Rare diseases, Liver diseases categories
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Summaries for Sclerosing Cholangitis

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Wikipedia:65 Primary sclerosing cholangitis (PSC) is a disease of the bile ducts that causes inflammation and... more...

MalaCards based summary: Sclerosing Cholangitis, also known as sclerosing cholangitis unspecified, is related to cholangitis and primary sclerosing cholangitis. An important gene associated with Sclerosing Cholangitis is CLDN1 (claudin 1), and among its related pathways are amb2 Integrin signaling and Resolution of Abasic Sites (AP sites). The compounds thymine glycol and carbohydrates have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Sclerosing Cholangitis

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Sclerosing Cholangitis, Aliases & Descriptions:

Name: Sclerosing Cholangitis 8 10
Sclerosing Cholangitis Unspecified 8
 
Cholangitis, Sclerosing 62
Fibrosing Cholangitis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:14268
MeSH34 D015209

Related Diseases for Sclerosing Cholangitis

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Graphical network of the top 20 diseases related to Sclerosing Cholangitis:



Diseases related to sclerosing cholangitis

Symptoms for Sclerosing Cholangitis

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Drugs & Therapeutics for Sclerosing Cholangitis

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Drug clinical trials:

Search ClinicalTrials for Sclerosing Cholangitis

Search NIH Clinical Center for Sclerosing Cholangitis

Genetic Tests for Sclerosing Cholangitis

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Anatomical Context for Sclerosing Cholangitis

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MalaCards organs/tissues related to Sclerosing Cholangitis:

32
Liver, Colon, Testes, Thyroid, T cells, Bone, Pancreas, Neutrophil, Bone marrow, Lymph node, Lung

Animal Models for Sclerosing Cholangitis or affiliated genes

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MGI Mouse Phenotypes related to Sclerosing Cholangitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6HP, MST1, NEIL1, GPBAR1
2MP:00020068.6NUDT1, NEIL1, NTHL1, HP
3MP:00053977.8NUDT1, MST1, IL21, HP, CARD9
4MP:00053766.9CARD9, GPBAR1, NUDT1, CLDN1, NEIL1, NTHL1
5MP:00053876.9FUT2, NUDT1, NEIL1, MST1, IL21, HP

Publications for Sclerosing Cholangitis

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Articles related to Sclerosing Cholangitis:

(show top 50)    (show all 766)
idTitleAuthorsYear
1
Dedicator of cytokinesis 8 deficiency: A predisposition to sclerosing cholangitis. (25220305)
2014
2
Reply to intrapancreatic biliary stricture in autoimmune pancreatitis should not be included in IgG4-related sclerosing cholangitis. (25207661)
2014
3
Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis. (25181933)
2014
4
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (22821403)
2013
5
Primary Sclerosing Cholangitis: Current and Future Management Strategies. (23682242)
2013
6
Effects of immunosuppression and liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. (23376317)
2013
7
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
8
Incidence of colorectal cancer after liver transplantation for primary sclerosing cholangitis: a systematic review and meta-analysis. (24019127)
2013
9
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
10
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
11
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
12
Primary sclerosing cholangitis and distribution of inflammatory bowel disease. (22835578)
2012
13
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
14
Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans. (21934101)
2012
15
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
16
Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity. (22098817)
2012
17
Factors that reduce health-related quality of life in patients with primary sclerosing cholangitis. (22343690)
2012
18
Primary sclerosing cholangitis: new approaches to diagnosis, surveillance and treatment. (23075867)
2012
19
Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease. (22407885)
2012
20
Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review. (22245904)
2012
21
Recognition of other organ involvement might assist in the differential diagnosis of IgG4-associated sclerosing cholangitis without apparent pancreatic involvement: report of two cases. (22855009)
2012
22
Overlapping of primary biliary cirrhosis and small duct primary sclerosing cholangitis: first case report. (23226177)
2012
23
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. (21134112)
2011
24
The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (21892037)
2011
25
Electrostatic modifications of the human leukocyte antigen DR P9 peptide-binding pocket in primary sclerosing cholangitis: back to the future with human leukocyte antigen DRI^. (21538433)
2011
26
High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. (21556038)
2011
27
Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. (21893134)
2011
28
Primary sclerosing cholangitis associated with elevated immunoglobulin G4: clinical characteristics and response to therapy. (20228674)
2011
29
Coexistence of primary sclerosing cholangitis in a patient with myasthenia gravis. (22346028)
2011
30
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
31
Sclerosing cholangitis: pediatric perspective. (20425475)
2010
32
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. (20347497)
2010
33
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
34
Cholangioscopy for special applications: primary sclerosing cholangitis, liver transplant, and selective duct access. (19917463)
2009
35
Long-term treatment of primary sclerosing cholangitis in children with oral vancomycin: an immunomodulating antibiotic. (18607270)
2008
36
Risk factors for recurrence of primary sclerosing cholangitis after liver transplantation. (18236405)
2008
37
Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. (18200656)
2008
38
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. (17335678)
2007
39
Primary sclerosing cholangitis. (17440311)
2007
40
Primary sclerosing cholangitis--the arteriosclerosis of the bile duct? (17254334)
2007
41
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (16638702)
2006
42
CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis. (16633049)
2006
43
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
44
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis. (15215889)
2004
45
BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. (14999697)
2004
46
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. (16378294)
2002
47
The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis. (11495087)
2001
48
Primary sclerosing cholangitis in a child. (10365542)
1999
49
Sclerosing cholangitis associated with hypereosinophilic syndrome. (9260773)
1997
50
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993

Variations for Sclerosing Cholangitis

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Expression for genes affiliated with Sclerosing Cholangitis

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Expression patterns in normal tissues for genes affiliated with Sclerosing Cholangitis

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Pathways for genes affiliated with Sclerosing Cholangitis

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Compounds for genes affiliated with Sclerosing Cholangitis

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Sources:
44Novoseek
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Compounds related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thymine glycol449.7NTHL1, NEIL1
2carbohydrates449.6HP, FUT2
38-oxoguanine449.4NEIL1, NUDT1
4con a449.2HP, IL21
5tyrosine448.2GPBAR1, MST1, IL21, HP

GO Terms for genes affiliated with Sclerosing Cholangitis

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Biological processes related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to oxidative stressGO:0069799.4NEIL1, NUDT1
2base-excision repairGO:0062849.3NTHL1, NEIL1

Molecular functions related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA-(apurinic or apyrimidinic site) lyase activityGO:0039069.6NTHL1, NEIL1
2DNA N-glycosylase activityGO:0191049.3NTHL1, NEIL1

Products for genes affiliated with Sclerosing Cholangitis

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Sources for Sclerosing Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet