MCID: SCL009
MIFTS: 49

Sclerosing Cholangitis malady

Summaries for Sclerosing Cholangitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Primary sclerosing cholangitis (PSC) is a disease of the bile ducts that causes inflammation and... more...

MalaCards: Sclerosing Cholangitis, also known as sclerosing cholangitis unspecified, is related to cholangitis and ulcerative colitis. An important gene associated with Sclerosing Cholangitis is CLDN1 (claudin 1), and among its related pathways is Cell adhesion molecules (CAMs). The compounds carbohydrates and thymine glycol have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Sclerosing Cholangitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

sclerosing cholangitis 8 10
sclerosing cholangitis unspecified 8
cholangitis, sclerosing 60
fibrosing cholangitis 8


External Ids:

Disease Ontology8 DOID:14268
MeSH34 D015209

Related Diseases for Sclerosing Cholangitis

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17GeneCards, 18GeneDecks
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Diseases in the Primary Sclerosing Cholangitis family:

sclerosing cholangitis

Diseases related to Sclerosing Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1cholangitis32.2GGT1
2ulcerative colitis31.5CTSG, MICB, IL21, MADCAM1
3pancreatitis31.3SCT, GGT1
4hepatitis31.2HP, GGT1
5inflammatory bowel disease31.2IL21, SLC22A5, SCT, CTSG, MADCAM1, MICB
6primary sclerosing cholangitis31.1CTSG, MADCAM1, GGT1
7crohn's disease31.0SLC22A5
8colorectal cancer30.7KLRK1, NUDT1
9cystic fibrosis30.7SCT, HP, CTSG
10adenocarcinoma30.4SCT, GGT1, KLRK1
11celiac disease30.1MICB, KLRK1
12hepatitis c30.1HP, GGT1
13systemic lupus erythematosus30.1KLRK1, ICOS, CTSG, IL21
14adenoma30.1GGT1, SCT, NUDT1
15intrahepatic cholestasis30.1GGT1, SCT
16cholangiocarcinoma10.9
17primary biliary cirrhosis10.8
18autoimmune hepatitis10.7
19liver disease10.7
20ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.6
21chronic cholangitis10.6
22hepatitis a10.6
23colonic disease10.5
24liver cirrhosis10.5
25cryptosporidiosis10.4
26duodenitis10.4
27bile duct carcinoma10.4
28thyroiditis10.4
29pericholangitis10.4
30cholecystitis10.4
31dermatitis10.4
32pancreatic cancer10.4
33acalculous cholecystitis10.3
34acute cholangitis10.3
35amyloidosis10.3
36cholestasis10.3
37dermatitis herpetiformis10.3
38gallbladder disease10.3
39histiocytosis10.3
40langerhans-cell histiocytosis10.3
41burns10.2
42x-linked hyper igm syndrome10.2
43autoimmune hemolytic anemia10.2
44suppurative cholangitis10.2
45alopecia10.2
46bile duct disease10.2
47colon cancer10.2
48eosinophilia10.2
49hemolytic anemia10.2
50hodgkin's lymphoma10.2

Graphical network of the top 20 diseases related to Sclerosing Cholangitis:



Diseases related to sclerosing cholangitis

Clinical Features for Sclerosing Cholangitis

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Drugs & Therapeutics for Sclerosing Cholangitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sclerosing Cholangitis

Drug clinical trials:

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Search NIH Clinical Center for Sclerosing Cholangitis

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Genetic Tests for Sclerosing Cholangitis

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Anatomical Context for Sclerosing Cholangitis

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32MalaCards
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MalaCards organs/tissues related to Sclerosing Cholangitis:

32
Liver, Colon, T cells, Testes, Thyroid, Bone, Pancreas, Lung, Lymph node, Bone marrow

Animal Models for Sclerosing Cholangitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sclerosing Cholangitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4ICOS, CTSG, MADCAM1, NUDT1, HP, IL21
2MP:000538710.4FUT2, KLRK1, CARD9, ICOS, CTSG, NEIL1
3MP:000537610.3NTHL1, NEIL1, SCT, ICOS, CARD9, NUDT1
4MP:000200610.2KLRK1, CTSG, NUDT1, HP

Publications for Sclerosing Cholangitis

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50PubMed
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Articles related to Sclerosing Cholangitis:

(show top 50)    (show all 753)
idTitleAuthorsYear
1
Is there an association between vitiligo and primary sclerosing cholangitis? (23330846)
2014
2
Effects of immunosuppression and liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. (23376317)
2013
3
Diagnosis, prognosis, and management of primary sclerosing cholangitis. (23935556)
2013
4
Impact of ileal pouch-anal anastomosis on the surgical outcome of orthotopic liver transplantation for primary sclerosing cholangitis. (22789675)
2013
5
Primary sclerosing cholangitis is associated with autoreactive IgA antibodies against biliary epithelial cells. (23713804)
2013
6
Liver transplantation for "mass-forming" sclerosing cholangitis after laparoscopic cholecystectomy. (23995476)
2013
7
Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. (23348121)
2013
8
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
9
Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis. (22140074)
2012
10
Primary sclerosing cholangitis and bile acids. (23141889)
2012
11
Severe coagulopathy caused by rifampicin in patients with primary sclerosing cholangitis and refractory pruritus. (22122359)
2012
12
Alcohol consumption in patients with primary sclerosing cholangitis. (22791946)
2012
13
Primary sclerosing cholangitis associated with elevated immunoglobulin-g4: a preliminary study. (22988518)
2012
14
Inflammatory bowel disease is associated with poor outcomes of patients with primary sclerosing cholangitis. (21893134)
2011
15
Coexistence of primary sclerosing cholangitis in a patient with myasthenia gravis. (22346028)
2011
16
Medical and endoscopic therapy of primary sclerosing cholangitis. (22117639)
2011
17
Current trends in living donor liver transplantation for primary sclerosing cholangitis. (21544035)
2011
18
IgG4-related sclerosing cholangitis: liver biopsy findings. (21494082)
2011
19
I^-Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotic effects in a model of nonsinusoidal fibrosis. (20921947)
2011
20
IgG4-related sclerosing cholangitis. (21911897)
2011
21
Diagnostic utility of chromosome 17 and p16 abnormalities in fluorescence in situ hybridization tests in primary sclerosing cholangitis. (20583197)
2010
22
IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater's ampulla and the bile duct. (20880174)
2010
23
Fluorescent in situ hybridization testing in primary sclerosing cholangitis: useful testing or a random chance result? (20034029)
2010
24
Benign mucous membrane pemphigoid concurrent with primary sclerosing cholangitis. (19405234)
2009
25
Autoimmune pancreatitis, sclerosing cholangitis, liver inflammatory pseudotumors, retroperitoneal fibrosis, lymphadenopathy, and sialoadenitis in a single patient: a multifaceted expression of a hitherto unrecognized systemic autoimmune syndrome? (19390412)
2009
26
Primary sclerosing cholangitis: the role of extrahepatic biliary resection. (19845177)
2009
27
Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis. (19475683)
2009
28
Leukocytapheresis Therapy Improved Cholestasis in a Patient Suffering from Primary Sclerosing Cholangitis with Ulcerative Colitis. (20651970)
2009
29
Characteristics and long-term prognosis of the autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome. (18769363)
2009
30
Pancreatic changes in patients with primary sclerosing cholangitis: MR cholangiopancreatography and MRI findings. (18282675)
2009
31
Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? (18751930)
2009
32
Gallbladder disease in patients with primary sclerosing cholangitis. (18626441)
2008
33
Proctocolectomy-ileal pouch-anal anastomosis for ulcerative colitis after liver transplantation for primary sclerosing cholangitis: a multi-institutional analysis. (18449613)
2008
34
Outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis. (18397233)
2008
35
Primary sclerosing cholangitis--the arteriosclerosis of the bile duct? (17254334)
2007
36
Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis. (17383044)
2007
37
Treatment of primary sclerosing cholangitis. (17391626)
2007
38
Overlapping syndrome of autoimmune hepatitis and primary sclerosing cholangitis associated with ulcerative colitis. (17492280)
2007
39
Liver transplantation in sickle cell anemia: a case of acute sickle cell intrahepatic cholestasis and a case of sclerosing cholangitis. (16371935)
2005
40
Recurrent acalculous cholecystitis and sclerosing cholangitis in a patient with X-linked hyper-immunoglobulin M syndrome. (16037832)
2005
41
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
42
Perforating folliculitis with jaundice in an Indian male: a rare case with sclerosing cholangitis. (15030363)
2004
43
A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis. (11438501)
2001
44
p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer. (11180865)
2000
45
Abnormal liver function tests induced by dapsone in a patient with dermatitis herpetiformis and primary sclerosing cholangitis. (10417547)
1999
46
Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis. (10629565)
1999
47
Diffuse lymphoplasmacytic acalculous cholecystitis: a distinctive form of chronic cholecystitis associated with primary sclerosing cholangitis. (9596276)
1998
48
Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study. (9924426)
1998
49
Ursodeoxycholic acid therapy in treatment of primary sclerosing cholangitis. (7824879)
1994
50
Riedel's thyroiditis, retroperitoneal fibrosis, and sclerosing cholangitis: diseases with one pathogenesis? (8504980)
1993

Genetic Variations for Sclerosing Cholangitis

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Expression for genes affiliated with Sclerosing Cholangitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sclerosing Cholangitis

Search GEO for disease gene expression data for Sclerosing Cholangitis.

Pathways for genes affiliated with Sclerosing Cholangitis

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29KEGG
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Pathways related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CLDN1, MADCAM1, ICOS

Compounds for genes affiliated with Sclerosing Cholangitis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1carbohydrates4410.7CTSG, MADCAM1, FUT2, HP
2thymine glycol4410.7NEIL1, NTHL1
3aspartate4410.7GGT1, HP, APEH, SCT, MADCAM1, CTSG
4dopamine44 28 11 2413.7GGT1, SLC22A5, SCT, NUDT1, GPBAR1
5malondialdehyde4410.6GGT1, CTSG, HP
6epinephrine44 11 2412.6HP, SCT, CTSG, SLC22A5
7phospholipid4410.6GPBAR1, SCT, CTSG, HP
8urea44 11 2412.5GGT1, CTSG, HP
98-oxoguanine4410.5NEIL1, NUDT1
10naltrexone44 49 28 1113.4GGT1, SCT
11arginine4410.3KLRK1, SLC22A5, CTSG, GGT1, SCT
12lipid4410.1APEH, GGT1, GPBAR1, HP, SCT, CTSG

GO Terms for genes affiliated with Sclerosing Cholangitis

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16Gene Ontology
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Biological processes related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.4IL21, MADCAM1, CTSG, ICOS
2response to oxidative stressGO:00697910.2NUDT1, MICB, NEIL1

Molecular functions related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA-(apurinic or apyrimidinic site) lyase activityGO:00390610.5NTHL1, NEIL1
2DNA N-glycosylase activityGO:01910410.2NTHL1, NEIL1

Products for genes affiliated with Sclerosing Cholangitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sclerosing Cholangitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet