Sclerosing Cholangitis malady

Genetics Home Reference: Primary sclerosing cholangitis is a condition that affects the bile ducts. These ducts carry bile (a fluid that helps to digest fats) from the liver, where bile is produced, to the gallbladder, where it is stored, and to the small intestine, where it aids in digestion. Primary sclerosing cholangitis occurs because of inflammation in the bile ducts (cholangitis) that leads to scarring (sclerosis) and narrowing of the ducts. As a result, bile cannot be released to the gallbladder and small intestine, and it builds up in the liver.¹⁷

MalaCards: Sclerosing Cholangitis, also known as sclerosing cholangitis unspecified (disorder), is related to primary sclerosing cholangitis and crohn's disease. An important gene associated with Sclerosing Cholangitis is CLDN1 (claudin 1), and among its related pathways are Bacterial infections in CF airways and Cell adhesion molecules (CAMs). The compounds endotoxin and budesonide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: Primary sclerosing cholangitis (PSC) is a chronic liver disease caused by progressive inflammation and...⁴⁴ more...

Aliases & Descriptions:

sclerosing cholangitis 6 8 sclerosing cholangitis unspecified (disorder) 6 sclerosing cholangitis (disorder) 6

cholangitis, sclerosing 43 fibrosing cholangitis 6

Diseases related to sclerosing cholangitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 962)

id	Related Disease	Score	Top Affiliating Genes
1	primary sclerosing cholangitis	37.9	BPI, CFTR, MPO, ENO1, MADCAM1, GPT
2	crohn's disease	33.0	MPO, MADCAM1, NOD2
3	hepatitis	31.6	SEPSECS, GPT, F2, ALB, HLA-A, HLA-DRB1
4	cholangiocarcinoma	29.6	SCT, MUTYH, CEACAM3, CDKN2A, MICA, IL6
5	autoimmune hepatitis	29.5	SEPSECS, CD40LG, GSTT1, GPT, F2, HLA-A
6	primary biliary cirrhosis	28.9	SEPSECS, SCT, LBR, CD79A, CD40LG, ENO1
7	hepatitis b	28.5	IL10, CCR5, GPT, IFNG, F2, ALB
8	ulcerative colitis	28.0	BPI, CFTR, MPO, CD28, CD79A, CD86
9	inflammatory bowel disease	26.3	BPI, SCT, MPO, CD28, CD86, MMP1
10	cystic fibrosis	25.2	BPI, SCT, LBR, CFTR, CEACAM3, MPO
11	cholangitis	23.7	REL, KITLG, KIR3DL1, SEPSECS, BPI, CLDN1
12	blindness	21.4	SCT, CFTR, CEACAM3, MPO, CD79A, CDKN2A
13	fibrosis	21.3	KITLG, SEPSECS, BPI, SCT, LBR, CFTR
14	esophagitis	19.6	KITLG, CLDN1, SCT, MUTYH, CFTR, CEACAM3
15	pancreatitis	17.4	KITLG, BPI, CLDN1, SCT, MUTYH, CFTR
16	carcinoma	16.4	REL, KITLG, KIR3DL1, SEPSECS, CLDN1, SCT
17	cholestasis, progressive familial intrahepatic 1	13.9	ABCB11, ABCB4, GGT1
18	gastrointestinal system disease	13.8	SCT, MADCAM1, NR1I2, LTF
19	tubulointerstitial nephritis and uveitis	13.8	HLA-DQA1, HLA-DQB1, HLA-DRB1
20	hypersensitivity vasculitis	13.8	MPO, CD79A, PRTN3
21	digestive diseases	13.7	GPT, CAT, ABCB4, GGT1
22	reactive arthritis	13.7	BPI, CD79A, HP, HLA-B, LTF, PRTN3
23	extrahepatic cholestasis	13.7	MPO, GPT, GGT1
24	obstructive jaundice	13.7	GPT, ALPP, SLC17A5, GGT1
25	birdshot chorioretinopathy	13.7	KIR3DL1, HLA-A, HLA-C
26	postherpetic neuralgia	13.7	HLA-A, HLA-B, HLA-DRB1
27	rapidly progressive glomerulonephritis	13.7	MPO, ICAM1, PRTN3
28	creatine phosphokinase	13.7	GPT, ALPP, SLPI, SLC17A5, GGT1
29	mast cell neoplasm	13.7	KITLG, MMP3, CTLA4, CTSG
30	pars planitis	13.7	HLA-A, HLA-B, HLA-DRB1
31	cervical dystonia	13.6	HLA-DQA1, HLA-DQB1, HLA-DRB1
32	angiodysplasia	13.6	SCT, F3, SST
33	adult glioblastoma multiforme	13.6	HLA-A, HLA-B, HLA-C, HLA-DRB1
34	aggressive periodontitis	13.6	MMP1, HLA-B, LTF
35	neonatal intrahepatic cholestasis caused by citrin deficiency	13.6	GPT, F2, SLC17A5
36	non-a-e hepatitis	13.6	GPT, F2, SLC17A5
37	pityriasis rosea	13.6	HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1
38	allergic bronchopulmonary aspergillosis	13.6	CFTR, IL4, IGHE
39	hyper-ige syndrome	13.6	CD79A, IGHE, IFNG, CARD9
40	membranous glomerulonephritis	13.6	CD79A, CCR5, ALB, HP
41	osteomalacia	13.6	GSTT1, ALPP, CALCA, NR1I2, SLPI
42	intrahepatic cholestasis	13.6	SCT, ALPP, NR1I2, ABCB11, ABCB4, ABCC2
43	citrin deficiency	13.6	GPT, F2, SLC17A5
44	hemosiderosis	13.5	IGHE, CAT, CALCA, CP
45	alcoholism	13.5	SCT, LBR, CFTR, GPT, SLC17A5, CP
46	hepatic tuberculosis	13.5	F2, ALB, ALPP, GGT1
47	hereditary pancreatitis	13.5	SCT, CFTR, CEACAM3, GSTT1, SST, LTF
48	acute diarrhea	13.5	IGHE, ALB, LTF
49	vulvovaginal candidiasis	13.5	CD79A, IL4, F2, GGT1
50	dysphagia	13.5	F3, ALB, PRTN3, CP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sclerosing cholangitis:

²²

MGI Mouse Phenotypes related to sclerosing cholangitis:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	CALCA, CFTR, REL
2	renal/urinary system phenotype	MP:0005367	10.3	NEIL1, SLC22A5, HBB, ABCC2
3	hematopoietic system phenotype	MP:0005397	9.6	CD28, CD86, IL21, IL23R, MADCAM1, CCL25
4	endocrine/exocrine gland phenotype	MP:0005379	9.3	GGT1, CTLA4, IFNG, GPBAR1, IL2, CD40LG
5	no phenotypic analysis	MP:0003012	9.1	KRT19, NR1I2, SST, TP53, HLA-C, ICOS
6	other phenotype	MP:0005395	8.8	ABCB1, NOS2, NTHL1, IL2, CD40LG, CDKN2A
7	skeleton phenotype	MP:0005390	8.6	HBB, KRT19, NOD2, NR3C1, CTLA4, TP53
8	nervous system phenotype	MP:0003631	8.6	DLG5, NR3C1, KRT19, HBB, TLR4, SLC17A5
9	liver/biliary system phenotype	MP:0005370	8.4	REL, CFTR, IL2, IL6, CCR5, GPBAR1
10	integument phenotype	MP:0010771	8.2	TP53, CTLA4, NR3C1, KRT19, HBB, TLR4
11	growth/size phenotype	MP:0005378	8.0	DLG5, SST, NR3C1, KRT19, HBB, TLR4
12	digestive/alimentary phenotype	MP:0005381	8.0	F2, SST, CTLA4, NR3C1, NOD2, NOS2
13	reproductive system phenotype	MP:0005389	7.8	NOS2, KRT19, ABCB4, HBB, TLR4, NEIL1
14	normal phenotype	MP:0002873	7.7	ALPP, HLA-DQB1, SST, CTLA4, CTSG, NR3C1
15	immune system phenotype	MP:0005387	7.3	NEIL1, GGT1, PRTN3, TLR4, IL23R, IL6
16	vision/eye phenotype	MP:0005391	7.2	F3, TP53, TNF, NOS2, TLR4, SLC17A5
17	mortality/aging	MP:0010768	6.9	NOD2, NR3C1, NR1I2, CTSG, CTLA4, TP53
18	tumorigenesis	MP:0002006	6.8	TNF, CTSG, NTHL1, NOS2, KRT19, KLRK1
19	behavior/neurological phenotype	MP:0005386	6.5	TP53, TNF, DLG5, SST, NTHL1, NR1I2
20	cardiovascular system phenotype	MP:0005385	5.9	NOS2, NR3C1, CTLA4, TNF, TP53, KRT19
21	homeostasis/metabolism phenotype	MP:0005376	5.4	REL, ICOS, F3, F2, ALB, CARD9
22	cellular phenotype	MP:0005384	4.2	ATG16L1, CD28, CD79A, CD86, CDKN2A, CD40LG

Articles related to sclerosing cholangitis:

(show top 50)    (show all 95)

id	Title	Authors	Year	Affiliating Genes
1	TGR5 sequence variation in primary sclerosing cholang itis. (21691110)	Hov J.R.... Karlsen T.H.	2011	GPBAR1
2	Analysis of IL2/IL21 gene variants in cholestatic liv er diseases reveals an association with primary sclerosing cholangitis. (21304239)	Stallhofer J.... Pusl T.	2011	IL2, IL21
3	Lack of glycoprotein 130/signal transducer and activa tor of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis. (20382701)	Plum W.... Streetz K.L.	2010	TNF
4	Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. (20811628)	Hov J.R.... Karlsen T.H.	2010	GPBAR1
5	Minocycline in the treatment of patients with primary sclerosing cholangitis: results of a pilot study. (19098854)	Silveira M.G.... Lindor K.D.	2009	NOS2, IL10
6	Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis. (18992954)	Henckaerts L.... Cuppens H.	2009	CFTR
7	An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis. (18397431)	Melum E.... Boberg K.M.	2008	IL6
8	Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients. (18715515)	Gaj P.... Ostrowski J.	2008	SLC22A5, NOD2, SLC22A4
9	Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function. (17719933)	Pall H.... Freedman S.D.	2007	CFTR
10	Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis. (17301827)	Karlsen T.H.... Lie B.A.	2007	HLA-DQB1, HLA-DRB1
11	Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. (17257319)	Wiencke K.... Spurkland A.	2007	HLA-DQA1, HLA-DQB1, HLA-DRB1
12	Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis. (17100974)	Karlsen T.H.... Boberg K.M.	2007	ABCB1, TLR4, NOD1
13	CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis. (16633049)	Henckaerts L.... Vermeire S.	2006	CCR5
14	The association of HLA-DR13 with lower graft survival rates in hepatitis B and primary sclerosing cholangitis Caucasian patients receiving a liver transplant. (16555323)	Futagawa Y.... Cai J.	2006	HLA-DRB1
15	Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. (16750586)	Bowlus C.L.... Boberg K.M.	2006	ICAM1, MADCAM1
16	The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. (16774544)	Melum E.... Lie B.A.	2006	CCR5
17	Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis. (16952547)	Karlsen T.H.... Boberg K.M.	2006	NR1I2
18	Which patients with primary biliary cirrhosis or primary sclerosing cholangitis should undergo endoscopic screening for oesophageal varices detection? (15710991)	Bressler B.... Heathcote E.J.	2005	ALB
19	Autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome in a child: diagnostic usefulness of magnetic resonance cholangiopancreatography. (15813880)	Lee W.S.... Sarji S.A.	2005	ALPP
20	Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. (15521008)	Hadj-Rabia S.... Smahi A.	2004	CLDN1
21	A pilot study exploring the role of glucocorticoid receptor variants in primary biliary cirrhosis and primary sclerosing cholangitis. (15635817)	er Borg P.C.... Lamberts S.W.	2004	NR3C1
22	Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients. (15288468)	Wiencke K.... Boberg K.M.	2004	MMP3, MMP1
23	Bile acids for primary sclerosing cholangitis. (12804480)	Chen W.... Gluud C.	2003	ALB
24	Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis. (12783301)	Sheth S.... Freedman S.D.	2003	CFTR
25	Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. (14567462)	Neri T.M.... Okolicsanyi L.	2003	TNF, CFTR, HLA-DQB1
26	X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder neoplasm: clinical case (12790080)	RodrA-guez C.... Ochs H.D.	2003	CD40LG
27	Treatment of primary sclerosing cholangitis with low- dose ursodeoxycholic acid: results of a retrospective Italian multicentre surve y. (12846404)	Okolicsanyi L.... Zuin M.	2003	GGT1, GPT
28	p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma. (12360471)	Taniai M.... Gores G.J.	2002	CDKN2A
29	Susceptibility to primary sclerosing cholangitis in Brazil is associated with HLA-DRB1*13 but not with tumour necrosis factor alpha -308 promoter polymorphism. (12235090)	Bittencourt P.L.... Goldberg A.C.	2002	TNF, HLA-DQB1, HLA-DRB1
30	Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. (11454187)	Oswald M.... Beuers U.	2001	ABCC2, SLCO1B1
31	A controlled trial of calcitonin therapy for the prevention of post-liver transplantation atraumatic fractures in patients with primary biliary cirrhosis and primary sclerosing cholangitis. (11281559)	Hay J.E.... Dickson E.R.	2001	CALCA
32	Treatment of cholangiocarcinoma complicating primary sclerosing cholangitis: the Mayo Clinic experience. (11316165)	Kaya M.... Lindor K.D.	2001	SST
33	No beneficial effects of transdermal nicotine in patients with primary sclerosing cholangitis: results of a randomized double-blind placebo-controlled cross-over study. (11246617)	Vleggaar F.P.... van Erpecum K.J.	2001	APEH, SLC17A5
34	Overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis in two cases. (10833101)	Griga T.... May B.	2000	GPT
35	Sclerosing cholangitis. (17023986)	Martins E.B.... Chapman R.W.	1999	HLA-C
36	Does ursodeoxycholic acid mediate immunomodulatory and anti-inflammatory effects in patients with primary sclerosing cholangitis? (10102223)	van Milligen de Wit A.W.... van Deventer S.J.	1999	LBR
37	Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis. (10629565)	Tsuneyama K.... Nakanuma Y.	1999	KITLG
38	Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. (9502419)	Crosby H.A.... Strain A.J.	1998	KRT19
39	Cytokine production from colonic T cells in patients with ulcerative colitis with and without primary sclerosing cholangitis. (9860336)	BroomAc U.... Yi Q.	1998	IL4, IFNG
40	Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features. (9831423)	Roozendaal C.... Kallenberg C.G.	1998	LTF, CTSG, BPI
41	Serum levels of interleukins 8 and 10, interferon gamma, granulocyte-macrophage colony stimulating factor and soluble CD23 in patients with primary sclerosing cholangitis. (9543183)	Bansal A.S.... Strong R.	1997	IL8, IL10
42	p53 Protein overexpression in cholangiocarcinoma aris ing in primary sclerosing cholangitis. (8801209)	Rizzi P.M.... Williams R.	1996	TP53
43	Primary sclerosing cholangitis associated with increa sed peripheral eosinophils and serum IgE. (8887045)	Shimomura I.... Okuno M.	1996	IGHE
44	Survey of cystic fibrosis transmembrane conductance regulator genotypes in primary sclerosing cholangitis. (8617131)	McGill J.M.... Hunt C.M.	1996	CFTR
45	Colchicine treatment of primary sclerosing cholangiti s. (7698589)	Olsson R.... Wallerstedt S.	1995	CP
46	HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis. (7875491)	Olerup O.... Broome U.	1995	HLA-A
47	Serum tumor markers for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. (7875490)	Ramage J.K.... Williams R.	1995	CEACAM3
48	Ursodeoxycholic acid therapy in treatment of primary sclerosing cholangitis. (7824879)	Stiehl A.	1994	GGT1, SLC17A5
49	Induced expression of heat-shock protein on biliary e pithelium in patients with primary sclerosing cholangitis and primary biliary c irrhosis. (8340058)	BroomAc U.... Hultcrantz R.	1993	HTLVR
50	A survey of cytomegalovirus (CMV) DNA in primary sclerosing cholangitis (PSC) liver tissues using a sensitive polymerase chain reaction (PCR) based assay. (1333001)	Mehal W.Z.... Fleming K.A.	1992	HBB

Genes related to sclerosing cholangitis according to GeneCards:

(show top 50)    (show all 91)

id	Symbol	Description	Score	GeneCards Section Context
1	CLDN1	claudin 1	11.1	Summaries, Publications
2	HP	haptoglobin	11.1	Summaries
3	HTLVR	human T-cell leukemia virus (I and II) receptor	11.0	Publications
4	CARD9	caspase recruitment domain family, member 9	11.0	Publications
5	NTHL1	nth endonuclease III-like 1 (E. coli)	11.0	Publications
6	GPBAR1	G protein-coupled bile acid receptor 1	11.0	Publications
7	NEIL1	nei endonuclease VIII-like 1 (E. coli)	11.0	Publications
8	MADCAM1	mucosal vascular addressin cell adhesion molecule 1	11.0	Publications
9	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	11.0	Publications
10	APEH	N-acylaminoacyl-peptide hydrolase	11.0	Publications
11	SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	11.0	Publications
12	ICOS	inducible T-cell co-stimulator	11.0	Publications
13	MICB	MHC class I polypeptide-related sequence B	11.0	Publications
14	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	11.0	Publications
15	PRTN3	proteinase 3	11.0	Publications
16	BPI	bactericidal/permeability-increasing protein	11.0	Publications
17	ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	11.0	Publications
18	CTSG	cathepsin G	11.0	Publications
19	ENO1	enolase 1, (alpha)	11.0	Publications
20	IL21	interleukin 21	11.0	Publications
21	NOD1	nucleotide-binding oligomerization domain containing 1	11.0	Publications
22	MUTYH	mutY homolog (E. coli)	11.0	Publications
23	SCT	secretin	11.0	Publications
24	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications
25	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
26	KLRK1	killer cell lectin-like receptor subfamily K, member 1	11.0	Publications
27	REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	11.0	Publications
28	SLCO1B1	solute carrier organic anion transporter family, member 1B1	11.0	Publications
29	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
30	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
31	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
32	TJP1	tight junction protein 1	11.0	Publications
33	GGT1	gamma-glutamyltransferase 1	11.0	Publications
34	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
35	CD86	CD86 molecule	11.0	Publications
36	DLG5	discs, large homolog 5 (Drosophila)	11.0	Publications
37	LBR	lamin B receptor	11.0	Publications
38	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	11.0	Publications
39	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
40	LTF	lactotransferrin	11.0	Publications
41	CD28	CD28 molecule	11.0	Publications
42	IL23R	interleukin 23 receptor	11.0	Publications
43	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
44	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	11.0	Publications
45	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
46	NR1I2	nuclear receptor subfamily 1, group I, member 2	11.0	Publications
47	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
48	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
49	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
50	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications

Pathways related to sclerosing cholangitis according to GeneDecks:

(show top 50)    (show all 99)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.8	REL, CFTR
2	Cell adhesion molecules (CAMs)20	10.6	CLDN1, CD28, MADCAM1, CD86, CTLA4, ICOS
3	Antigen processing and presentation20	10.4	HLA-C, KIR3DL1, HLA-DQB1, HLA-DQA1, HLA-DRB1
4	Immune response_NFAT in immune response41	10.3	CD28, IGHE
5	Immune response NFAT in immune response10	10.2	HLA-DQA1, CD79A, REL, HLA-DQB1, CD86, CD28
6	Immune response_Bacterial infections in normal airways41	10.1	IFNG, NOS2, CFTR, REL
7	CTL Mediated Apoptosis36	9.9	HLA-B, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-A
8	Graft-versus-host disease20	9.9	HLA-DQA1, HLA-C, HLA-B, HLA-A, IL2, CD86
9	Cytokine production by Th17 cells in CF (Mouse model)41	9.9	CFTR, REL, TLR4, IL8, IL6, IL21
10	Cytokine production by Th17 cells in CF41	9.8	IL8, REL, CFTR, IL23R, IL6, TLR4
11	NOD-like receptor signaling pathway20	9.7	CARD9, TNF, NOD1, IL8, NOD2, IL6
12	Amoebiasis20	9.6	IL6, IL8, CTSG, NOS2, TLR4
13	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.6	IL21, IFNG, IL6, IL4, IL23R, TLR4
14	Natural killer cell mediated cytotoxicity20	9.5	HLA-C, HLA-B, HLA-A, ICAM1, TNF, IFNG
15	Viral myocarditis20	9.4	HLA-A, HLA-B, HLA-C, CD28, ICAM1, CD40LG
16	Th1 Differentiation37	9.3	TNF, IL2, IL10, CD86, TLR4, IFNG
17	RAR-Gamma-RXR-Alpha Degradation36	9.2	IL21, IL2, CCL25, CCL5
18	Asthma20	9.2	HLA-DQA1, TNF, HLA-DRB1, CD40LG, HLA-DQB1, IL4
19	Type I diabetes mellitus20	9.1	TNF, HLA-DQB1, HLA-DQA1, HLA-C, HLA-DRB1, HLA-B
20	Immune response_MIF in innate immunity response41	9.1	TNF, NOS2, TLR4, TP53, IFNG, IL6
21	Immune response MIF in innate immunity response10	9.1	TP53, NOS2, IFNG, TNF, IL6, IL8
22	Leishmaniasis20	9.1	HLA-DQB1, HLA-DQA1, IFNG, IL10, IL4, TLR4
23	Immune System38	9.1	REL, KIR3DL1, CD79A, MICB, ICOS, IFNG
24	African trypanosomiasis20	9.1	HBB, IL10, ICAM1, IFNG, IL6, TNF
25	Pertussis20	9.0	IL10, IL6, IL8, TNF, NOD1, NOS2
26	THC Differentiation Pathway36	8.9	IL10, IL4, HLA-DQB1, HLA-DQA1, IL2, IFNG
27	Tuberculosis20	8.9	TLR4, IL10, IL6, IFNG, CARD9, HLA-DQA1
28	Systemic lupus erythematosus20	8.9	CTSG, CD28, CD86, TNF, CD40LG, IL10
29	Influenza A20	8.8	IFNG, CCL5, IL8, IL6, HLA-DQB1, HLA-DQA1
30	Cytokine Network36	8.8	IFNG, TNF, IL8, IL6, IL4, IL10
31	Immune response MIF-mediated glucocorticoid regulation10	8.7	TNF, NR3C1, NOS2, ICAM1, IFNG, IL8
32	Immune response_MIF-mediated glucocorticoid regulation41	8.7	REL, MMP1, IL2, IL6, IL8, IFNG
33	Rheumatoid arthritis20	8.6	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, ICAM1, IFNG
34	Toxoplasmosis20	8.6	CD40LG, IL10, CCR5, IFNG, HLA-DQA1, HLA-DQB1
35	Autoimmune thyroid disease20	8.6	CTLA4, CD28, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
36	T cell receptor signaling pathway20	8.6	IL4, IFNG, TNF, IL2, CD40LG, ICOS
37	Chagas disease (American trypanosomiasis)20	8.5	IL10, TLR4, IFNG, IL2, IL6, TNF
38	MIF Regulation of Innate Immune Cells36	8.5	IL4, IL21, IL2, IL10, CCL5, IL6
39	Akt Signaling36	8.4	TNF, CD28, CCL5, CCL25, CCR5, IL6
40	Malaria20	8.4	IL10, IFNG, IL8, CD40LG, ICAM1, IL6
41	all-trans-Retinoic Acid Signaling in Brain36	8.4	IL21, CCL5, IL8, CCL25, IL4, IL10
42	MIF Mediated Glucocorticoid Regulation36	8.4	TLR4, NR3C1, TNF, CCL5, CCL25, IL8
43	PEDF Induced Signaling36	8.4	IL6, IL2, IL8, IL10, CCL25, CCL5
44	Intestinal immune network for IgA production20	8.3	HLA-DRB1, ICOS, HLA-DQB1, CD28, CD86, CD40LG
45	STAT3 Pathway36	8.3	IL21, CCL25, TNF, CCL5, CCR5, IL6
46	Allograft rejection20	8.1	TNF, CD40LG, CD86, CD28, IL10, IL2
47	Tec Kinases Signaling36	8.0	CCL5, TNF, TLR4, IL10, CCL25, CCR5
48	p38 Signaling36	7.8	CCL5, TP53, IL6, CD28, IL2, IL21
49	Antioxidant Action of Vitamin-C36	7.7	IL8, CCR5, CCL25, CCL5, IL6, IL21
50	Cytokine-cytokine receptor interaction20	7.4	KITLG, IFNG, TNF, CCL5, CCL25, CCR5

Compounds related to sclerosing cholangitis according to GeneDecks:

(show top 50)    (show all 435)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	10.4	SLC17A5, SLPI, LTF, CTSG, HP, F3
2	budesonide32 42 9 9	13.4	LTF, NR3C1, IGHE, KITLG
3	ivig32	10.3	CCR5, SEPSECS
4	pge232	10.0	CD86, CFTR, SCT, MMP1, MMP3, SLPI
5	ascorbic acid32 18	10.7	SLC17A5, SLPI, LTF, ALPP, IGHE, GSTT1
6	hyaluronic acid32 18	10.5	F2, GPT, MMP3, MMP1, KRT19, LTF
7	calcitriol32 42 9 18 9	13.4	SLPI, NR1I2, CALCA, ALPP, ALB, CCL5
8	heparin32 9 18 9	12.3	ALB, F2, F3, CCL5, MMP3, CD79A
9	h2o232	9.3	SLC17A5, NUDT1, TLR4, LTF, CTSG, TJP1
10	n acetylcysteine32	9.3	CFTR, CD79A, SLC17A5, TLR4, ABCC2, LTF
11	oxygen32 18	10.1	NEIL1, CEACAM3, MUTYH, KITLG, MPO, CDKN2A
12	ursodeoxycholic acid32 9 18 9	12.1	GGT1, SLCO1B1, SLC17A5, ABCC2, ABCB4, ABCB11
13	phenytoin32 34 9 9	11.8	GGT1, CP, SLC17A5, ABCC2, ABCB11, ABCB1
14	infliximab32 9 9	10.8	TNF, IFNG, IGHE, IL6, IL4, IL10
15	polyinosinic-polycytidylic acid32	8.6	TLR4, KLRK1, NOS2, HLA-B, IFNG, IL8
16	okt332	8.6	TNF, HTLVR, ICAM1, IL6, IL2, IL10
17	aspartate32	8.5	GGT1, SLC17A5, CEACAM3, CFTR, SCT, CDKN2A
18	ribavirin32 34 9 9	11.5	IFNG, GPT, CCR5, IL4, IL2, IL10
19	thyroxine32 18	9.3	IL4, IL10, CD40LG, CD79A, CEACAM3, SCT
20	il 1032	8.3	TLR4, NOD2, CTLA4, TNF, IFNG, CCL5
21	estrogen32	8.2	NR1I2, TJP1, HP, CALCA, ALPP, F2
22	vitamin d32	8.2	CP, SLPI, TLR4, NR3C1, NR1I2, CTLA4
23	cysteine32	8.1	CCL5, CCR5, APEH, MMP1, CD40LG, CDKN2A
24	cholesterol32 9 18 9	11.1	GGT1, CP, SLCO1B1, CCR5, IL6, MMP3
25	epinephrine32 9 18 9	11.0	NISCH, CTSG, HP, F2, F3, IGHE
26	mycophenolate mofetil32 9 9	10.0	SEPSECS, CD79A, CD40LG, GGT1, ABCC2, CTLA4
27	testosterone32 9 18 9	10.9	CD40LG, CDKN2A, CD79A, CFTR, LBR, SCT
28	pdtc32	7.8	CP, TLR4, NOS2, TNF, TP53, CAT
29	prednisolone32 9 9	9.6	IGHE, GPT, IL6, IL2, IL10, MMP3
30	neopterin32	7.6	IL8, IL6, IL4, IL2, IL10, CD40LG
31	simvastatin32 34 42 9 18 9	12.5	F2, F3, ICAM1, IFNG, GPT, CCL5
32	histamine32 18	8.5	CD86, CD79A, MPO, LBR, SCT, KITLG
33	methotrexate32 34 42 9 9	11.5	CTLA4, TNF, HLA-DRB1, ALB, F2, IGHE
34	tacrolimus32 34 9 9	10.5	GGT1, SLC17A5, TLR4, ABCC2, ABCB4, ABCB11
35	arginine32	7.4	HLA-DRB1, HLA-DQA1, HLA-B, HLA-A, ALPP, IGHE
36	vegf32	7.4	CCL5, MMP3, MMP1, CD40LG, MPO, CEACAM3
37	rantes32	7.3	ICAM1, REL, KITLG, SCT, IFNG, CCL5
38	hydrocortisone32 9 9	9.3	IL6, IL4, IL2, IL10, MMP1, KITLG
39	fibrinogen32	7.2	ALB, F2, F3, ICAM1, GPT, ENO1
40	lipid32	7.1	CD28, LBR, SCT, BPI, KIR3DL1, KITLG
41	indomethacin32 9 9	9.0	IL6, IL4, IL2, MMP3, MMP1, CD40LG
42	genistein32 9 18 9	9.7	MMP3, MMP1, CD40LG, CDKN2A, CD28, CFTR
43	alanine32	6.5	SLPI, PRTN3, TLR4, HBB, ABCB4, LTF
44	nitric oxide32 9 18 9	9.3	CALCA, CAT, ICAM1, IFNG, CCL5, MADCAM1
45	actinomycin d32	6.2	ABCB1, LTF, NOS2, NR3C1, TNF, TP53
46	cyclosporin a32 42	7.2	SLCO1B1, SLC17A5, SLPI, TLR4, ABCC2, CCL5
47	lactate32	5.8	ENO1, IL8, IL6, MMP3, MMP1, CD40LG
48	cycloheximide32	5.3	SLPI, PRTN3, TLR4, HBB, IFNG, IGHE
49	serine32	5.2	NOD2, NR3C1, NR1I2, CTSG, CTLA4, TJP1
50	retinoic acid32 42 18	6.8	CP, SLPI, PRTN3, TLR4, ABCC2, ABCB11

Cellular components related to sclerosing cholangitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	10.1	HLA-B, HLA-A, MICA, MICB, HLA-C
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
3	ER to Golgi transport vesicle membrane	GO:012507	9.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
4	external side of plasma membrane	GO:009897	8.2	ICOS, HLA-DRB1, TNF, CTLA4, TLR4, ICAM1
5	integral to plasma membrane	GO:005887	8.0	HLA-DQA1, HLA-DRB1, TNF, CTLA4, ABCB11, ABCB4
6	extracellular region	GO:005576	6.9	F2, ALB, CALCA, HP, HLA-C, SST
7	extracellular space	GO:005615	6.0	KITLG, ICAM1, F3, F2, ALB, CALCA
8	plasma membrane	GO:005886	6.0	NOD2, CTSG, CTLA4, DLG5, TJP1, TNF

Biological processes related to sclerosing cholangitis according to GeneDecks:

(show all 45)

id	Name	GO ID	Score	Top Affiliating Genes
1	defense response	GO:006952	10.4	NOD2, NOD1, HLA-B, HP, MPO
2	detection of bacterium	GO:016045	10.4	NOD2, NOD1, HLA-DRB1, HLA-B, HLA-A
3	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.3	HLA-C, HLA-B, HLA-A
4	positive regulation of interleukin-17 production	GO:032740	10.3	NOD2, IL23R, IL21, IL2
5	positive regulation of tumor necrosis factor production	GO:032760	10.3	TLR4, NOD2, NOD1, CARD9, IFNG
6	positive regulation of JNK cascade	GO:046330	10.3	TLR4, NOD2, NOD1, TNF, CARD9
7	positive regulation of interleukin-12 biosynthetic process	GO:045084	10.3	TLR4, IFNG, REL
8	T cell costimulation	GO:031295	10.3	CTLA4, HLA-DRB1, HLA-DQB1, HLA-DQA1, ICOS, CD86
9	base-excision repair	GO:006284	10.3	NEIL1, NTHL1, TP53, MUTYH
10	defense response to Gram-negative bacterium	GO:050829	10.1	IL23R, IL6, NOS2, TLR4
11	positive regulation of interleukin-6 production	GO:032755	10.1	TLR4, NOD2, NOD1, TNF, CARD9, IL6
12	negative regulation of interleukin-6 production	GO:032715	10.1	TLR4, TNF, IL10, BPI
13	defense response to Gram-positive bacterium	GO:050830	10.0	NOD1, TNF, CARD9, IL6
14	protein tetramerization	GO:051262	10.0	TP53, HLA-DRB1, CAT, CCL5
15	positive regulation of osteoclast differentiation	GO:045672	10.0	TNF, IFNG, CCL5, IL23R
16	defense response to virus	GO:051607	10.0	CARD9, IFNG, IL6, MICA, CD86
17	positive regulation of interleukin-10 production	GO:032733	10.0	TLR4, NOD2, IL4, IL21, CD40LG
18	positive regulation of chemokine biosynthetic process	GO:045080	9.9	TNF, IFNG, IL4
19	positive regulation of isotype switching to IgG isotypes	GO:048304	9.9	IFNG, IL4, IL2
20	response to activity	GO:014823	9.9	IL10, CCL5, TNF, NR3C1, TLR4
21	negative regulation of growth of symbiont in host	GO:044130	9.9	CTSG, TNF, IFNG, IL10
22	positive regulation of nitric oxide biosynthetic process	GO:045429	9.8	TLR4, HBB, TNF, ICAM1, IFNG
23	positive regulation of interleukin-12 production	GO:032735	9.8	CD40LG, IL23R, IFNG, TLR4
24	humoral immune response	GO:006959	9.8	LTF, TNF, IFNG, IL6, CD28
25	positive regulation of T cell proliferation	GO:042102	9.8	IFNG, CCL5, IL6, IL4, IL23R, IL21
26	leukocyte cell-cell adhesion	GO:007159	9.7	CALCA, ICAM1, CCL5, CD40LG
27	defense response to bacterium	GO:042742	9.7	TLR4, LTF, NOS2, NOD2, NOD1, IFNG
28	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.7	TLR4, NOD2, NOD1, TNF, CAT, ICAM1
29	B cell proliferation	GO:042100	9.6	CD79A, CD40LG, IL10
30	regulation of immune response	GO:050776	9.5	HLA-C, HLA-B, HLA-A, ICAM1, MADCAM1, IL4
31	positive regulation of interferon-gamma production	GO:032729	9.5	TLR4, TNF, IL23R, IL2, CD40LG
32	positive regulation of B cell proliferation	GO:030890	9.5	CD40LG, IL2, IL4, TLR4
33	positive regulation of MHC class II biosynthetic process	GO:045348	9.4	TLR4, IFNG, IL4, IL10, CD40LG
34	cellular response to lipopolysaccharide	GO:071222	9.3	TLR4, NOS2, ICAM1, IFNG, CCR5, IL8
35	B cell differentiation	GO:030183	9.3	CD79A, CD40LG, IL10, IL4
36	response to glucocorticoid stimulus	GO:051384	9.1	ABCB4, TNF, CCL5, IL6, IL10
37	response to drug	GO:042493	9.0	TNF, SST, ABCB1, ABCB4, CARD9, ICAM1
38	interferon-gamma-mediated signaling pathway	GO:060333	8.9	SP100, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
39	anti-apoptosis	GO:006916	8.6	NR3C1, TNF, F3, IL2, IL10, CD40LG
40	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.6	SP100, TNF, IL6, IL4, IL10
41	cytokine-mediated signaling pathway	GO:019221	8.5	SP100, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
42	virus-host interaction	GO:019048	8.5	KRT19, SP100, TP53, HLA-C, HLA-B, HLA-A
43	inflammatory response	GO:006954	8.2	NOD1, TNF, CALCA, CCL5, CCL25, CCR5
44	immune response	GO:006955	8.2	KIR3DL1, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1
45	positive regulation of transcription, DNA-dependent	GO:045893	7.8	NR1I2, SP100, TNF, TP53, IL6, IL4

Molecular functions related to sclerosing cholangitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CARD domain binding	GO:050700	10.4	CARD9, NOD1, NOD2
2	cytokine activity	GO:005125	7.7	TNF, IFNG, IL6, IL4, IL21, IL2
3	protein binding	GO:005515	4.0	GGT1, NOD2, NOD1, NR3C1, NR1I2, NTHL1