MCID: SCL009
MIFTS: 49

Sclerosing Cholangitis malady

Summaries for Sclerosing Cholangitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Primary sclerosing cholangitis (PSC) is a disease of the bile ducts that causes inflammation and... more...

MalaCards: Sclerosing Cholangitis, also known as sclerosing cholangitis unspecified, is related to primary sclerosing cholangitis and ulcerative colitis. An important gene associated with Sclerosing Cholangitis is CLDN1 (claudin 1), and among its related pathways is Cell adhesion molecules (CAMs). The compounds carbohydrates and thymine glycol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and colon, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Sclerosing Cholangitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

sclerosing cholangitis 8 10
sclerosing cholangitis unspecified 8
cholangitis, sclerosing 61
fibrosing cholangitis 8


External Ids:

Disease Ontology8 DOID:14268
MeSH35 D015209

Related Diseases for Sclerosing Cholangitis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the primary sclerosing cholangitis family:

sclerosing cholangitis

Diseases related to Sclerosing Cholangitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1primary sclerosing cholangitis32.2CTSG, MADCAM1, GGT1
2ulcerative colitis31.5IL21, MICB, MADCAM1, CTSG
3hepatitis c31.2HP, GGT1
4crohn's disease31.0SLC22A5
5colorectal cancer30.7NUDT1, KLRK1
6cystic fibrosis30.7SCT, CTSG, HP
7adenocarcinoma30.5GGT1, SCT, KLRK1
8celiac disease30.1MICB, KLRK1
9systemic lupus erythematosus30.1KLRK1, ICOS, CTSG, IL21
10adenoma30.1GGT1, NUDT1, SCT
11intrahepatic cholestasis30.1SCT, GGT1
12autoimmune pancreatitis10.9
13primary biliary cirrhosis10.8
14hepatitis a10.8
15autoimmune hepatitis10.8
16hepatitis d10.7
17ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.7
18chronic cholangitis10.6
19retroperitoneal fibrosis10.5
20cryptosporidiosis10.4
21bile duct carcinoma10.4
22hepatitis b10.4
23pericholangitis10.4
24n syndrome10.4
25thyroiditis10.4
26acalculous cholecystitis10.3
27hepatitis e10.3
28acute cholangitis10.3
29amyloidosis10.3
30pouchitis10.3
31riedel thyroiditis10.3
32autoimmune hemolytic anemia10.2
33suppurative cholangitis10.2
34alopecia10.2
35bile duct disease10.2
36hypereosinophilic syndrome10.2
37pancreatitis, chronic10.2
38bronchiolitis obliterans organizing pneumonia10.1
39bronchiolitis obliterans10.1
40anuria10.1
41antiphospholipid syndrome10.1
42bronchiolitis10.1
43duodenal ulcer10.1
44bardet-biedl syndrome10.1
45biliary atresia10.1
46sjogren's syndrome10.1
47folliculitis10.1
48wiskott-aldrich syndrome10.1
49aggressive systemic mastocytosis10.1
50alopecia universalis10.1

Graphical network of the top 20 diseases related to Sclerosing Cholangitis:



Diseases related to sclerosing cholangitis

Clinical Features for Sclerosing Cholangitis

Drugs & Therapeutics for Sclerosing Cholangitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sclerosing Cholangitis

Drug clinical trials:

Search ClinicalTrials for Sclerosing Cholangitis

Search NIH Clinical Center for Sclerosing Cholangitis

Search CenterWatch for Sclerosing Cholangitis

Genetic Tests for Sclerosing Cholangitis

Anatomical Context for Sclerosing Cholangitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Sclerosing Cholangitis:

33
Bone marrow, Lymph node, Colon, Liver, Lung, Pancreas, Thyroid, T cells, B cells, Temporal lobe, Pancreatic islet

Animal Models for Sclerosing Cholangitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Sclerosing Cholangitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4ICOS, CTSG, MADCAM1, NUDT1, HP, IL21
2MP:000538710.4FUT2, KLRK1, CARD9, ICOS, CTSG, NEIL1
3MP:000537610.3NTHL1, NEIL1, SCT, ICOS, CARD9, NUDT1
4MP:000200610.2KLRK1, CTSG, NUDT1, HP

Publications for Sclerosing Cholangitis

Sources:
51PubMed
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Articles related to Sclerosing Cholangitis:

(show top 50)    (show all 752)
idTitleAuthorsYear
1
Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. (24372568)
2014
2
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
3
Successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin. (23509657)
2013
4
IgG4-related intrahepatic sclerosing cholangitis resulting in sepsis caused by secondary suppurative inflammation: report of a case. (23247888)
2013
5
Primary sclerosing cholangitis. (23810223)
2013
6
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. (23603763)
2013
7
Commentary: vancomycin or metronidazole in patients with primary sclerosing cholangitis? (23551156)
2013
8
Ursodiol and colorectal cancer or dysplasia risk in primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis. (23896754)
2013
9
Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis. (23564624)
2013
10
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. (22398080)
2012
11
Recent insights in primary sclerosing cholangitis. (22713082)
2012
12
Gadoxetic acid-enhanced T1-weighted MR cholangiography in primary sclerosing cholangitis. (22581411)
2012
13
Primary sclerosing cholangitis: the gut-liver axis. (22343691)
2012
14
Severity of primary sclerosing cholangitis and its impact on the clinical outcome of Crohn's disease. (22398102)
2012
15
A case of IgG4-related sclerosing cholangitis overlapped with primary biliary cirrhosis. (22790128)
2012
16
S100A9 is a biliary protein marker of disease activity in primary sclerosing cholangitis. (22253789)
2012
17
Specificities of sclerosing cholangitis in childhood. (22633198)
2012
18
Diagnostic Dilemma in a Patient with Jaundice: How to Differentiate between Autoimmune Pancreatitis, Primary Sclerosing Cholangitis and Pancreas Carcinoma. (22649334)
2012
19
Mycosis as a cause of secondary sclerosing cholangitis requiring liver retransplantation. (21239959)
2011
20
Bile acids for primary sclerosing cholangitis. (21249655)
2011
21
Many patients with primary sclerosing cholangitis and increased serum levels of carbohydrate antigen 19-9 do not have cholangiocarcinoma. (21334457)
2011
22
Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model. (21762662)
2011
23
Restorative proctocolectomy and primary sclerosing cholangitis: an acceptable pairing? (21654241)
2011
24
Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis. (20740366)
2011
25
Natural history of small duct primary sclerosing cholangitis: a case series with review of the literature. (21484124)
2011
26
Colon neoplasms develop early in the course of inflammatory bowel disease and primary sclerosing cholangitis. (20920596)
2011
27
Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma. (20880060)
2010
28
Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. (20347497)
2010
29
Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment. (20189511)
2010
30
Endoscopic ultrasound elastography as a method for screening the patients with suspected primary sclerosing cholangitis. (19494783)
2010
31
Validation of a cholangiographic prognostic model in primary sclerosing cholangitis. (20623444)
2010
32
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
33
Immunoglobulin G4-related sclerosing cholangitis without pancreatic involvement. (19262061)
2009
34
Sclerosing cholangitis associated with good syndrome. (20128430)
2009
35
Primary sclerosing cholangitis. (18992601)
2008
36
Etiopathogenesis of primary sclerosing cholangitis. (18528932)
2008
37
Sarcoidosis mimicking primary sclerosing cholangitis requiring liver transplantation. (18376373)
2008
38
High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective. (18314215)
2008
39
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. (17335678)
2007
40
An endoscopic finding in patients with primary sclerosing cholangitis: retraction of the main duodenal papilla into the duodenum wall. (17321263)
2007
41
An autopsy case showing massive fibrinoid necrosis of the portal tracts of the liver with cholangiographic findings similar to those of primary sclerosing cholangitis. (17278236)
2007
42
IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis. (17335458)
2007
43
Tacrolimus for the treatment of primary sclerosing cholangitis. (17403184)
2007
44
Depression in patients with primary biliary cirrhosis and primary sclerosing cholangitis. (17399846)
2007
45
Treatment of primary sclerosing cholangitis with low-dose ursodeoxycholic acid: results of a retrospective Italian multicentre survey. (12846404)
2003
46
Primary sclerosing cholangitis is associated to an extended B8-DR3 haplotype including particular MICA and MICB alleles. (11584356)
2001
47
A controlled trial of calcitonin therapy for the prevention of post-liver transplantation atraumatic fractures in patients with primary biliary cirrhosis and primary sclerosing cholangitis. (11281559)
2001
48
Primary sclerosing cholangitis in Wiskott-Aldrich syndrome. (11176335)
2001
49
Survey of cystic fibrosis transmembrane conductance regulator genotypes in primary sclerosing cholangitis. (8617131)
1996
50
Suppressor T-cell deficiency in primary sclerosing cholangitis. Case and family study. (1832633)
1991

Genetic Variations for Sclerosing Cholangitis

Expression for genes affiliated with Sclerosing Cholangitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sclerosing Cholangitis

Search GEO for disease gene expression data for Sclerosing Cholangitis.

Pathways for genes affiliated with Sclerosing Cholangitis

Sources:
30KEGG
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Pathways related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5CLDN1, MADCAM1, ICOS

Compounds for genes affiliated with Sclerosing Cholangitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1carbohydrates4510.7CTSG, MADCAM1, HP, FUT2
2thymine glycol4510.7NTHL1, NEIL1
3aspartate4510.7GGT1, HP, MADCAM1, CTSG, SCT, APEH
4dopamine45 29 11 2413.7SCT, NUDT1, GPBAR1, SLC22A5, GGT1
5malondialdehyde4510.6GGT1, HP, CTSG
6epinephrine45 11 2412.6SCT, CTSG, HP, SLC22A5
7phospholipid4510.6GPBAR1, HP, CTSG, SCT
8urea45 11 2412.5CTSG, HP, GGT1
98-oxoguanine4510.5NUDT1, NEIL1
10naltrexone45 50 29 1113.4GGT1, SCT
11arginine4510.3KLRK1, SCT, CTSG, SLC22A5, GGT1
12lipid4510.1APEH, SCT, CTSG, HP, GPBAR1, GGT1

GO Terms for genes affiliated with Sclerosing Cholangitis

Sources:
16Gene Ontology
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Biological processes related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.4IL21, MADCAM1, CTSG, ICOS
2response to oxidative stressGO:00697910.2NUDT1, MICB, NEIL1

Molecular functions related to Sclerosing Cholangitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA-(apurinic or apyrimidinic site) lyase activityGO:00390610.5NTHL1, NEIL1
2DNA N-glycosylase activityGO:01910410.2NTHL1, NEIL1

Products for genes affiliated with Sclerosing Cholangitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Sclerosing Cholangitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet