MCID: SCL017
MIFTS: 46

Sclerosing Hemangioma malady

Summaries for Sclerosing Hemangioma

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous... more...

MalaCards: Sclerosing Hemangioma, also known as cutaneous fibrous histiocytoma, is related to adenocarcinoma and adenoma. An important gene associated with Sclerosing Hemangioma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Adherens junction and Glioma. The compounds guanine and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Sclerosing Hemangioma

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 57SNOMED-CT
See all sources

Aliases & Descriptions:

sclerosing hemangioma 8 10
cutaneous fibrous histiocytoma 61
sclerosing haemangioma 8


External Ids:

Disease Ontology8 DOID:495
SNOMED-CT57 72079004, 134302009

Related Diseases for Sclerosing Hemangioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sclerosing Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.5AR, CTNNB1, CTNND1, FOXM1, SFTPB, TUBA1B
2adenoma30.4CHGA, SYP, NKX2-1, CTNNB1, MYC, MUC1
3familial adenomatous polyposis30.3CTNND1, CTNNB1, MYC, CDH1, AXIN1
4colorectal cancer30.0CTNND1, CTNNB1, NKX2-1, MYC, CDH1, MMP9
5pulmonary sclerosing hemangioma11.0
6cutaneous fibrous histiocytoma10.9
7giant hemangioma10.3
8fibrous histiocytoma10.2
9familial hemangioma10.2
10pulmonary sequestration10.1
11spindle cell hemangioma10.1
12lymphangioleiomyomatosis10.1
13small cell carcinoma10.1
14hemangioendothelioma10.1
15soft tissue sarcoma10.1
16hemangioma, hereditary10.1
17epithelioid hemangioendothelioma10.1
18angiomyolipoma10.0ACTC1
19thymoma10.0NKX2-1
20hemangioma of lung10.0SFTPB
21lobular neoplasia10.0CTNND1
22pulmonary blastoma10.0NKX2-1
23chordoma10.0MUC1
24cerebral primitive neuroectodermal tumor10.0ENO2
25papilloma10.0ACTC1
26cystadenocarcinoma10.0MUC1
27gastritis10.0CHGA
28ductal carcinoma in situ10.0CDH1
29somatostatinoma10.0CHGA
30sertoli-leydig cell tumor10.0MUC1
31hepatitis b10.0FOXM1
32pulmonary fibrosis10.0MMP9
33bladder carcinoma10.0CDH1
34laryngeal squamous cell carcinoma10.0CDH1
35bronchiolitis obliterans10.0TUBA1B
36stomach cancer10.0CDH1
37thyroid cancer10.0CHGA, NKX2-1
38hypertension10.0MMP9
39multiple endocrine neoplasia10.0CHGA
40fasciitis10.0ACTC1
41huntington's disease10.0AR
42gastrointestinal system disease10.0CDH1
43meningioma10.0SYP, MUC1
44esophageal cancer10.0CDH1
45gynecomastia10.0AR
46gastrointestinal stromal tumor10.0ENO2, ACTC1
47meningitis10.0MMP9
48leiomyoma10.0ESR2, ACTC1
49pulmonary alveolar proteinosis10.0SFTPB, MUC1
50endometriosis10.0ESR2, ACTC1

Graphical network of the top 20 diseases related to Sclerosing Hemangioma:



Diseases related to sclerosing hemangioma

Clinical Features for Sclerosing Hemangioma

Drugs & Therapeutics for Sclerosing Hemangioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Sclerosing Hemangioma

Drug clinical trials:

Search ClinicalTrials for Sclerosing Hemangioma

Search NIH Clinical Center for Sclerosing Hemangioma

Search CenterWatch for Sclerosing Hemangioma

Genetic Tests for Sclerosing Hemangioma

Anatomical Context for Sclerosing Hemangioma

Animal Models for Sclerosing Hemangioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sclerosing Hemangioma:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.5ACTC1, AR
2MP:000537910.5MYC, ESR2
3MP:000538910.0CTNNB1, MYC, CDH1, MMP9
4MP:00053679.9CTNND1, AR, CHGA, AXIN1, ESR2
5MP:00107719.7CTNND1, CTNNB1, AR, MYC, CDH1, MMP9
6MP:00053889.7SFTPB, FOXM1, CTNNB1, AXIN1, MMP9, ENO2
7MP:00053699.6FOXM1, MYC, MMP9, ACTC1, ESR2
8MP:00053709.6ESR2, MUC1, MYC, AR, CTNNB1, FOXM1
9MP:00030129.5CTNNB1, NKX2-1, SYP, MYC, MUC1, CDH1
10MP:00053909.5AR, NKX2-1, MYC, AXIN1, ESR2
11MP:00028739.5CTNNB1, AR, SYP, MYC, MUC1, CDH1
12MP:00053819.4CTNND1, CTNNB1, AR, NKX2-1, MYC, MUC1
13MP:00020069.4ESR2, FOXM1, CTNND1, CTNNB1, AR, NKX2-1
14MP:00053869.2AR, CTNNB1, SFTPB, TUBA1A, NKX2-1, MYC
15MP:00053859.2FOXM1, CTNNB1, AR, NKX2-1, CHGA, MYC
16MP:00036319.2TUBA1A, CTNND1, CTNNB1, AR, NKX2-1, SYP
17MP:00053789.1TUBA1A, CTNNB1, AR, NKX2-1, CHGA, MYC
18MP:00107689.0AR, CTNNB1, CTNND1, FOXM1, SFTPB, NKX2-1
19MP:00053848.9AR, CTNNB1, CTNND1, FOXM1, TUBA1A, NKX2-1

Publications for Sclerosing Hemangioma

Sources:
51PubMed
See all sources

Articles related to Sclerosing Hemangioma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). (23587094)
2013
2
Napsin A is differentially expressed in sclerosing hemangiomas of the lung. (23194051)
2012
3
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. (22740968)
2012
4
Pulmonary sclerosing hemangioma: report of two cases. (22943472)
2012
5
In pulmonary sclerosing hemangioma expression of I^-catenin, Axin, and C-myc differs between the two cell types. (22614067)
2012
6
Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes. (20422318)
2011
7
Sclerosing hemangioma in the liver. (22102394)
2011
8
Multiple FDG-avid sclerosing hemangiomas mimicking pulmonary metastases in a case of soft tissue sarcoma. (20675249)
2010
9
So-called sclerosing hemangioma of lung: current concept. (20123460)
2010
10
Sclerosing hemangioma of the lung. (19415961)
2009
11
Sclerosing hemangioma with lymph nodal metastases. (19679971)
2009
12
Sclerosing hemangioma with an air halo. (19026830)
2008
13
Endobronchial sclerosing hemangioma: a rare presentation of a parenchymal tumor. (18245708)
2008
14
Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung. (18067639)
2008
15
Recurrence of pulmonary sclerosing hemangioma. (18278694)
2008
16
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. (17383052)
2007
17
Sclerosing hemangioma with florid endobronchial and endobronchiolar growth. (17120028)
2007
18
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. (17473941)
2007
19
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. (17914564)
2007
20
Bilateral multiple pulmonary sclerosing hemangioma. (15828298)
2005
21
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. (16305908)
2005
22
Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. (15201499)
2004
23
Pulmonary sclerosing hemangioma associated with familial adenomatous polyposis. (15188145)
2004
24
Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesis. (15270615)
2004
25
Clinicopathological analysis of pulmonary sclerosing hemangioma. (15561002)
2004
26
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. (12653576)
2003
27
Pulmonary sclerosing hemangioma with lymph node metastases. (14571291)
2003
28
Sclerosing hemangioma of the lung with cystic appearance. (12949064)
2003
29
The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. (11955335)
2002
30
Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma: the role of electron microscopy in preventing an erroneous diagnosis of metastasis. (12227952)
2002
31
Sclerosing hemangioma with metastases to multiple nodal stations. (11899220)
2002
32
Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): a new clue to its histogenesis. (11075855)
2000
33
Sclerosing hemangioma of the lung--benign sclerosing pneumocytoma. (10481534)
1999
34
Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney. (8702253)
1996
35
Positive expression of c-myc and p53 products in two cases of pulmonary sclerosing hemangioma]. (8821986)
1995
36
A case of sclerosing hemangioma of the lung: correlation of MR images with pathological findings. (7667514)
1995
37
Fine needle aspiration cytodiagnosis of pulmonary sclerosing hemangioma. (7762366)
1995
38
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
39
Sclerosing hemangioma of the lung. Granulomatous variant. (7944888)
1994
40
Sclerosing hemangioma of the lung: a clinicopathologic study. (8252456)
1993
41
Pulmonary sclerosing hemangioma of the lung. A type II pneumocytoma by immunohistochemical and immunoelectron microscopic studies. (2548701)
1989
42
So-called sclerosing hemangioma of the lung--two cases report with ultrastructural study. (2561731)
1989
43
Sclerosing hemangioma of the lung: report of a case. (2824660)
1987
44
Fine needle aspiration cytology of sclerosing hemangioma of the lung, a mimicker of bronchioloalveolar carcinoma. (3004083)
1986
45
Sclerosing hemangioma of the lung. Immunohistochemical characterization of its origin as related to surfactant apoprotein. (2981138)
1985
46
Pulmonary sclerosing hemangioma: sometimes a form of pulmonary hamartoma. (7089615)
1982
47
Sclerosing hemangioma of the lung: a clinicopathologic study of 51 cases. (6252791)
1980
48
Sclerosing hemangioma of the lung: an ultrastructural study. (225006)
1979
49
Electron microscopic study of so-called "pulmonary sclerosing hemangioma". Report of a case suggesting epithelial origin. (4342853)
1972
50
Sclerosing hemangioma. (14867901)
1951

Genetic Variations for Sclerosing Hemangioma

Expression for genes affiliated with Sclerosing Hemangioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sclerosing Hemangioma

Search GEO for disease gene expression data for Sclerosing Hemangioma.

Pathways for genes affiliated with Sclerosing Hemangioma

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN, 53R&D Systems, 56SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CTNND1
2
Hide members
10.2AR, MYC
310.2CDH1, CTNND1
410.2CTNNB1, CDH1
510.2CDH1, CTNNB1
610.1CTNND1, CTNNB1, AXIN1
710.1AR, MYC, AXIN1
8
Cell adhesion Gap junctions
Hide members
10.0ACTC1, TUBA1A, TUBA1B
910.0AXIN1, MYC, CTNNB1
1010.0AXIN1, MYC, CTNNB1
1110.0ESR2, MYC, AR
1210.0CTNNB1, MUC1, CDH1
1310.0CTNND1, CTNNB1, CDH1
1410.0CTNND1, CTNNB1, CDH1
1510.0CTNND1, CDH1, MMP9
1610.0CTNNB1, MYC, CDH1
17
Hide members
9.9CDH1, CTNNB1, CTNND1, SFTPA1
18
Hide members
9.9CTNND1, CTNNB1, MYC, AXIN1
199.9ACTC1, CDH1, CTNNB1, CTNND1
209.9CDH1, MUC1, CTNNB1, CTNND1
219.9TUBA1B, NKX2-1, SYP, ENO2
229.9ESR2, MYC, AR, CTNNB1
239.9CTNNB1, MYC, CDH1, AXIN1
249.9CTNNB1, MYC, CDH1, AXIN1
25
Hide members
9.9AXIN1, CDH1, MYC, CTNNB1
26
Hide members
9.9AXIN1, CDH1, MYC, CTNNB1
279.9AXIN1, CDH1, MYC, CTNNB1
28
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
9.9TUBA1B, TUBA1A, CTNNB1, AXIN1
299.9CTNNB1, AR, MYC, CDH1
309.9FOXM1, CTNNB1, AR, ESR2
31
Hide members
9.8ESR2, AXIN1, CDH1, MYC, CTNND1
329.8ACTC1, CDH1, CTNND1, TUBA1A, TUBA1B
33
Development Slit-Robo signaling
Hide members
9.7TUBA1B, TUBA1A, CTNNB1, CDH1, ACTC1
34
Hide members
9.7CTNNB1, MYC, MUC1, CDH1, MMP9
359.7MMP9, CDH1, MYC, AR, CTNNB1
369.6MMP9, AXIN1, CDH1, MYC, AR, CTNNB1

Compounds for genes affiliated with Sclerosing Hemangioma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1guanine45 11 2412.7AR
2cycloheximide4510.6SFTPB
3dihydrotestosterone45 29 11 2413.6ESR2
4butyrate4510.6TUBA1B
5glutamate4510.5TUBA1B, AR
6mucicarmine4510.4ACTC1, NKX2-1, SYP, MUC1
7smcc4510.4SYP, ENO2, CHGA
8s 1004510.2ENO2, SYP, CHGA, MUC1, ACTC1
9estramustine45 1111.2TUBA1B, AR, CHGA, ESR2
10cyclopamine45 6011.2CTNNB1, MYC, CDH1
11bicalutamide45 60 1112.2CTNNB1, ESR2, CHGA, AR
12b 7234510.2NKX2-1, MUC1, CDH1, ACTC1, CHGA, SYP
13etoposide45 50 60 1113.1CHGA, AR, TUBA1B, CDH1, ESR2
14creatinine4510.1SYP, ACTC1, CHGA, CDH1, MMP9
15forskolin45 50 1112.1ENO2, NKX2-1, TUBA1B
16silver4510.1TUBA1B, SYP, CHGA, ENO2, CDH1
17steroid4510.1NKX2-1, FOXM1, ACTC1, SYP, TUBA1B, AR
182,4-dinitrophenol4510.0SFTPB, NKX2-1, AR
19paclitaxel45 50 1112.0TUBA1B, CTNNB1, CHGA, CDH1, MYC
20hyaluronic acid45 2411.0CDH1, MUC1, MYC, MMP9, ENO2
21retinoid459.9AR, CTNNB1, ESR2, SFTPB, CDH1, MYC
22agar459.9CDH1, MUC1, MYC, CTNNB1, AR, FOXM1
23docetaxel45 50 60 1112.9TUBA1A, TUBA1B, AR, MYC, CDH1, ENO2
24matrigel459.9CTNNB1, AR, CHGA, MUC1, CDH1, MMP9
25curcumin459.9CDH1, MYC, AR, CTNNB1, MMP9
26tamoxifen45 50 29 1112.8ESR2, CTNNB1, AR, MYC, MUC1, CHGA
2712-o-tetradecanoylphorbol 13-acetate459.8MYC, CHGA, FOXM1, SFTPB, MUC1, CDH1
28hematoxylin459.8ENO2, ACTC1, MMP9, CDH1, MUC1, CHGA
295-aza-2deoxycytidine459.8MYC, CTNNB1, ESR2, CDH1, AR
30formaldehyde45 2410.8ENO2, CHGA, NKX2-1, ACTC1, MMP9, CDH1
31genistein45 29 60 2 11 2414.8SYP, AR, CTNNB1, CDH1, MMP9, ESR2
32actinomycin d459.8MYC, ESR2, AR, SFTPB, MMP9, MUC1
33sucrose45 11 2411.8CDH1, CHGA, SYP, CTNNB1, SFTPB
34serine459.8TUBA1B, MMP9, CDH1, SFTPB, CTNND1, NKX2-1
35chloramphenicol45 2 1111.8MMP9, FOXM1, MYC, CHGA, MUC1, AR
36dmso459.7MUC1, ENO2, CHGA, MYC, ESR2
37doxorubicin45 50 1111.7MYC, TUBA1B, AR, CDH1, ESR2, CTNNB1
38ribonucleic acid459.7CHGA, MUC1, MYC, SFTPB, MMP9, ACTC1
39cisplatin45 50 60 1112.7CHGA, TUBA1B, CTNNB1, SYP, MYC, MUC1
40vitamin a45 11 2411.6SFTPB, MMP9, CTNNB1, MYC
41glycogen45 2410.6CTNNB1, SYP, TUBA1B, CHGA, ENO2, MYC
42dexamethasone45 50 29 1112.6CTNNB1, NKX2-1, MYC, CDH1, MMP9, ENO2
43cysteine459.5TUBA1B, SFTPB, CTNNB1, SYP, CHGA, ESR2
44testosterone45 60 11 2412.5ESR2, ENO2, ACTC1, MMP9, CDH1, CHGA
45progesterone45 60 29 11 2413.4SFTPB, CTNNB1, AR, NKX2-1, ESR2, ENO2
46calcium45 50 11 2412.2SFTPA1, MUC1, CHGA, SYP, CDH1, ACTC1
47paraffin459.1ESR2, NKX2-1, AR, ENO2, ACTC1, MMP9
48tyrosine459.1SYP, CHGA, MUC1, CDH1, MMP9, ACTC1
49vegf458.9TUBA1B, SFTPB, CTNND1, CTNNB1, AR, MMP9
50retinoic acid45 249.8TUBA1B, SFTPB, FOXM1, NKX2-1, AR, MYC

GO Terms for genes affiliated with Sclerosing Hemangioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.2AXIN1, CTNNB1
2cell-cell adherens junctionGO:00591310.1CDH1, CTNNB1, CTNND1
3lateral plasma membraneGO:01632810.0AXIN1, CTNNB1, CDH1
4cytoplasmic microtubuleGO:0058819.9AXIN1, TUBA1B, TUBA1A
5catenin complexGO:0163429.9CDH1, CTNNB1

Biological processes related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiation involved in prostate gland developmentGO:06074210.4AR, CTNNB1
2cellular response to indole-3-methanolGO:07168110.4CDH1, CTNNB1
3regulation of protein localization to cell surfaceGO:200000810.4CDH1, CTNNB1
4cytoskeleton-dependent intracellular transportGO:03070510.4TUBA1B, TUBA1A
5prostate gland epithelium morphogenesisGO:06074010.3AR, ESR2
6negative regulation of stress-activated MAPK cascadeGO:03287310.3FOXM1, MYC
7dorsal/ventral axis specificationGO:00995010.3CTNNB1, AXIN1
8epithelial tube branching involved in lung morphogenesisGO:06044110.2CTNNB1, NKX2-1
9canonical Wnt receptor signaling pathwayGO:06007010.2CTNNB1, MYC, AXIN1
10cell-cell adhesionGO:0163379.9CTNNB1, CTNND1, CDH1
11negative regulation of transcription from RNA polymerase II promoterGO:0001229.8ESR2, MYC, NKX2-1, CTNNB1, FOXM1
12positive regulation of transcription, DNA-dependentGO:0458939.7CDH1, MYC, NKX2-1, AR, CTNNB1, FOXM1
13response to drugGO:0424939.6ACTC1, MYC, CTNNB1, CDH1

Molecular functions related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:01990310.2CTNND1, CTNNB1, CDH1
2beta-catenin bindingGO:00801310.2AXIN1, CDH1, AR
3transcription regulatory region DNA bindingGO:04421210.1NKX2-1, FOXM1, CTNNB1, AR
4structural constituent of cytoskeletonGO:00520010.1TUBA1A, TUBA1B, SYNM
5enzyme bindingGO:01989910.0AXIN1, CTNNB1, ESR2, AR
6I-SMAD bindingGO:0704119.9AXIN1, CTNNB1
7transcription factor bindingGO:0081349.8AR, MYC, FOXM1, CTNNB1
8sequence-specific DNA binding transcription factor activityGO:0037009.6AR, FOXM1, CTNNB1, NKX2-1, ESR2, MYC
9protein bindingGO:0055158.7MMP9, MUC1, MYC, SYNM, NKX2-1, AR

Products for genes affiliated with Sclerosing Hemangioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sclerosing Hemangioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet