MCID: SCL017
MIFTS: 54

Sclerosing Hemangioma malady

Summaries for Sclerosing Hemangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous... more...

MalaCards: Sclerosing Hemangioma, also known as cutaneous fibrous histiocytoma, is related to hemangioma and hemangioma of lung. An important gene associated with Sclerosing Hemangioma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Adherens junction and Glioma. The compounds guanine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and thyroid, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Sclerosing Hemangioma

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60UMLS, 8Disease Ontology, 10DISEASES, 56SNOMED-CT
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Aliases & Descriptions:

sclerosing hemangioma 8 10
cutaneous fibrous histiocytoma 60
sclerosing haemangioma 8


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Disease Ontology8 DOID:495
SNOMED-CT56 72079004, 134302009

Related Diseases for Sclerosing Hemangioma

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17GeneCards, 18GeneDecks
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Diseases related to Sclerosing Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.6NKX2-1, ACTC1, SFTPB
2hemangioma of lung31.4SFTPB
3adenocarcinoma30.4CDH1, AXIN1, MMP9, ACTC1, ENO2, ESR2
4giant cell tumor30.2MUC1, MMP9, ACTC1
5familial adenomatous polyposis30.2CTNND1, CTNNB1, MYC, CDH1, AXIN1
6lung adenocarcinoma30.2SFTPB, FOXM1, CTNNB1, NKX2-1, MUC1, CDH1
7papillary adenocarcinoma30.0MUC1, NKX2-1
8sarcoma30.0ENO2, ACTC1, MUC1, AR
9neuroendocrine tumor30.0NKX2-1, SYP, CHGA, ENO2
10non-small cell lung carcinoma30.0MYC, SFTPB, SYP, CHGA, ENO2, NKX2-1
11lung small cell carcinoma30.0SYP, CHGA, MYC, MUC1, ENO2, NKX2-1
12breast cancer30.0AR, CTNNB1, MYC, CDH1, ESR2, CTNND1
13colorectal cancer30.0MMP9, CDH1, MYC, NKX2-1, CTNNB1, CTNND1
14melanoma30.0CTNND1, ENO2, ACTC1, MMP9, CDH1, NKX2-1
15lung cancer30.0SFTPB, ESR2, ENO2, MYC, CHGA, NKX2-1
16pulmonary sclerosing hemangioma10.9
17cutaneous fibrous histiocytoma10.8
18thyroiditis10.4
19giant hemangioma10.3
20hemangioma of liver10.2
21fibrous histiocytoma10.2
22hepatitis a10.2
23hepatitis10.2
24histiocytoma10.2
25spindle cell hemangioma10.0
26lymphangioleiomyomatosis10.0
27small cell carcinoma10.0
28breast hemangioma10.0
29cavernous hemangioma10.0
30glomangioma10.0
31mediastinitis10.0
32angiomyolipoma10.0ACTC1
33thymoma10.0NKX2-1
34lobular neoplasia10.0CTNND1
35pulmonary blastoma10.0NKX2-1
36chordoma10.0MUC1
37cerebral primitive neuroectodermal tumor10.0ENO2
38papilloma10.0ACTC1
39cystadenocarcinoma10.0MUC1
40gastritis10.0CHGA
41ductal carcinoma in situ10.0CDH1
42somatostatinoma10.0CHGA
43sertoli-leydig cell tumor10.0MUC1
44hepatitis b10.0FOXM1
45pulmonary fibrosis10.0MMP9
46bladder carcinoma10.0CDH1
47laryngeal squamous cell carcinoma10.0CDH1
48bronchiolitis obliterans10.0TUBA1B
49stomach cancer10.0CDH1
50thyroid cancer10.0NKX2-1, CHGA

Graphical network of the top 20 diseases related to Sclerosing Hemangioma:



Diseases related to sclerosing hemangioma

Clinical Features for Sclerosing Hemangioma

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Drugs & Therapeutics for Sclerosing Hemangioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sclerosing Hemangioma

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Anatomical Context for Sclerosing Hemangioma

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32MalaCards
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MalaCards organs/tissues related to Sclerosing Hemangioma:

32
Lung, Skin, Thyroid, Lymph node, Liver, Endothelial, Kidney, Tongue, Bone, Breast, Fetal lung

Animal Models for Sclerosing Hemangioma or affiliated genes

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36MGI
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Publications for Sclerosing Hemangioma

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50PubMed
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Articles related to Sclerosing Hemangioma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Pneumocytoma (formerly known as sclerosing hemangioma of the lung): a rare cause of chest pain. (23380035)
2013
2
Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. (23838116)
2013
3
Cytologic features of sclerosing hemangioma of the lung on crush preparations. (21710650)
2013
4
Napsin A is differentially expressed in sclerosing hemangiomas of the lung. (23194051)
2012
5
A case of pulmonary sclerosing hemangioma with low (18)FDG uptake in PET. (22740968)
2012
6
F-18 FDG PET/CT in evaluation of pulmonary sclerosing hemangioma. (21467848)
2011
7
Pulmonary sclerosing hemangioma with pleural dissemination: report of a case. (21264765)
2011
8
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection. (22263122)
2011
9
A case of sclerosing hemangioma evaluated with diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography. (21057447)
2010
10
So-called sclerosing hemangioma of lung: current concept. (20123460)
2010
11
Sclerosing hemangioma with florid endobronchial and endobronchiolar growth. (17120028)
2007
12
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. (17473941)
2007
13
Increased expression of matrix metalloproteinase 9 and tubulin-alpha in pulmonary sclerosing hemangioma. (17914564)
2007
14
Radiology-pathology conference: sclerosing hemangioma of the lung. (17101410)
2006
15
Pulmonary sclerosing hemangioma presenting as solitary pulmonary nodule: dynamic CT findings and histopathologic comparisons. (16861548)
2006
16
Sclerosing hemangioma. (15954523)
2005
17
Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. (16305908)
2005
18
Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. (15201499)
2004
19
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. (15138814)
2004
20
A case of sclerosing hemangioma surrounded by emphysematous change. (15176609)
2004
21
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. (12653576)
2003
22
Sclerosing hemangioma with lymph node metastasis. (12619190)
2003
23
Sclerosing hemangioma of the lung with cystic appearance. (12949064)
2003
24
The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. (11955335)
2002
25
Sclerosing hemangioma of the lung in a young woman with cutaneous melanoma: the role of electron microscopy in preventing an erroneous diagnosis of metastasis. (12227952)
2002
26
Sclerosing hemangioma with metastases to multiple nodal stations. (11899220)
2002
27
Imprint cytologic features of pulmonary sclerosing hemangioma: comparison with well-differentiated papillary adenocarcinoma. (12115302)
2002
28
Sclerosing hemangioma of lung: A close cytologic mimicker of pulmonary adenocarcinoma. (11747223)
2001
29
Sclerosing hemangioma of the lung. (11089322)
2000
30
Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): a new clue to its histogenesis. (11075855)
2000
31
Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney. (8702253)
1996
32
Positive expression of c-myc and p53 products in two cases of pulmonary sclerosing hemangioma]. (8821986)
1995
33
Fine needle aspiration biopsy cytology of sclerosing hemangioma of the lung. A case report. (8249516)
1993
34
Pulmonary sclerosing hemangioma. Report of a case with diagnosis by fine needle aspiration. (1316026)
1992
35
Pulmonary sclerosing hemangioma of the lung. A type II pneumocytoma by immunohistochemical and immunoelectron microscopic studies. (2548701)
1989
36
Sclerosing hemangioma of the lung. An immunohistochemical study of intermediate filaments and endothelial markers. (2537067)
1989
37
So-called sclerosing hemangioma of the lung--two cases report with ultrastructural study. (2561731)
1989
38
So-called sclerosing hemangioma of the lung. An immunohistochemical, histochemical and ultrastructural study. (2463730)
1988
39
Sclerosing hemangioma of the lung. An epithelial tumor composed of immunohistochemically heterogenous cells. (2823596)
1987
40
Sclerosing hemangioma of the lung. Immunohistochemical demonstration of mesenchymal origin using antibodies to tissue-specific intermediate filaments. (3021315)
1986
41
Fine needle aspiration cytology of sclerosing hemangioma of the lung, a mimicker of bronchioloalveolar carcinoma. (3004083)
1986
42
Is sclerosing hemangioma of lung an alveolar mixed tumour? (6310472)
1983
43
So-called sclerosing hemangioma of the lung. Evidence for mesothelial origin. (6187231)
1983
44
Sclerosing hemangioma of the lung: report of a case with an ultrastructural study. (6251145)
1980
45
Sclerosing hemangioma of the lung: an endothelial or epithelial neoplasm? (196998)
1977
46
Ultrastructure of sclerosing hemangioma. (4372890)
1974
47
Unilateral mixed sclerosing bone dystrophy associated with unilateral lymphangiectasis and capillary hemangioma: a case report. (5055176)
1972
48
Ultrastructure of a sclerosing hemangioma of the lung. (4340663)
1972
49
Sclerosing hemangioma (histiocytoma, xanthoma) of the lung. (13284701)
1956
50
Sclerosing hemangioma. (14867901)
1951

Genetic Variations for Sclerosing Hemangioma

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Expression for genes affiliated with Sclerosing Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sclerosing Hemangioma

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Pathways for genes affiliated with Sclerosing Hemangioma

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CTNND1
2
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10.2MYC, AR
310.2CDH1, CTNND1
410.2CDH1, CTNNB1
510.2CDH1, CTNNB1
610.1AXIN1, CTNNB1, CTNND1
710.1AXIN1, MYC, AR
8
Cell adhesion Gap junctions
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10.0TUBA1A, ACTC1, TUBA1B
910.0AXIN1, CTNNB1, MYC
1010.0CTNNB1, MYC, AXIN1
1110.0ESR2, MYC, AR
1210.0CDH1, MUC1, CTNNB1
1310.0CTNNB1, CDH1, CTNND1
1410.0CDH1, CTNND1, CTNNB1
1510.0CDH1, MMP9, CTNND1
1610.0MYC, CTNNB1, CDH1
17
Hide members
9.9CDH1, CTNNB1, SFTPA1, CTNND1
18
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9.9CTNND1, CTNNB1, MYC, AXIN1
199.9CDH1, ACTC1, CTNND1, CTNNB1
209.9CTNNB1, CTNND1, MUC1, CDH1
219.9TUBA1B, NKX2-1, SYP, ENO2
229.9CTNNB1, AR, MYC, ESR2
239.9CTNNB1, CDH1, AXIN1, MYC
249.9MYC, CDH1, AXIN1, CTNNB1
25
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9.9MYC, AXIN1, CTNNB1, CDH1
26
Hide members
9.9CDH1, MYC, CTNNB1, AXIN1
279.9AXIN1, CDH1, MYC, CTNNB1
28
Cytoskeleton remodeling Reverse signaling by ephrin B
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9.9TUBA1B, TUBA1A, CTNNB1, AXIN1
299.9CDH1, CTNNB1, MYC, AR
309.9AR, CTNNB1, FOXM1, ESR2
31
Hide members
9.8ESR2, AXIN1, MYC, CTNND1, CDH1
329.8TUBA1B, CTNND1, CDH1, ACTC1, TUBA1A
33
Development Slit-Robo signaling
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9.7TUBA1B, TUBA1A, CTNNB1, ACTC1, CDH1
34
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9.7MUC1, MYC, MMP9, CTNNB1, CDH1
359.7AR, CTNNB1, MYC, CDH1, MMP9
369.6MYC, MMP9, AXIN1, CDH1, AR, CTNNB1

Compounds for genes affiliated with Sclerosing Hemangioma

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1guanine44 11 2412.7AR
2cycloheximide4410.6SFTPB
3dihydrotestosterone44 28 11 2413.6ESR2
4butyrate4410.6TUBA1B
5glutamate4410.5TUBA1B, AR
6mucicarmine4410.4ACTC1, NKX2-1, SYP, MUC1
7smcc4410.4SYP, ENO2, CHGA
8s 1004410.2ENO2, SYP, CHGA, MUC1, ACTC1
9estramustine44 1111.2TUBA1B, AR, CHGA, ESR2
10cyclopamine44 5911.2CTNNB1, MYC, CDH1
11bicalutamide44 59 1112.2CTNNB1, ESR2, CHGA, AR
12b 7234410.2NKX2-1, MUC1, CDH1, ACTC1, CHGA, SYP
13etoposide44 49 59 1113.1CHGA, AR, TUBA1B, CDH1, ESR2
14creatinine4410.1SYP, ACTC1, CHGA, CDH1, MMP9
15forskolin44 49 1112.1ENO2, NKX2-1, TUBA1B
16silver4410.1TUBA1B, SYP, CHGA, ENO2, CDH1
17steroid4410.1NKX2-1, FOXM1, ACTC1, SYP, TUBA1B, AR
182,4-dinitrophenol4410.0SFTPB, NKX2-1, AR
19paclitaxel44 49 1112.0TUBA1B, CTNNB1, CHGA, CDH1, MYC
20hyaluronic acid44 2411.0CDH1, MUC1, MYC, MMP9, ENO2
21retinoid449.9AR, CTNNB1, ESR2, SFTPB, CDH1, MYC
22agar449.9CDH1, MUC1, MYC, CTNNB1, AR, FOXM1
23docetaxel44 49 59 1112.9TUBA1A, TUBA1B, AR, MYC, CDH1, ENO2
24matrigel449.9CTNNB1, AR, CHGA, MUC1, CDH1, MMP9
25curcumin449.9CDH1, MYC, AR, CTNNB1, MMP9
26tamoxifen44 49 28 1112.8ESR2, CTNNB1, AR, MYC, MUC1, CHGA
2712-o-tetradecanoylphorbol 13-acetate449.8MYC, CHGA, FOXM1, SFTPB, MUC1, CDH1
28hematoxylin449.8ENO2, ACTC1, MMP9, CDH1, MUC1, CHGA
295-aza-2deoxycytidine449.8MYC, CTNNB1, ESR2, CDH1, AR
30formaldehyde44 2410.8ENO2, CHGA, NKX2-1, ACTC1, MMP9, CDH1
31genistein44 28 59 2 11 2414.8SYP, AR, CTNNB1, CDH1, MMP9, ESR2
32actinomycin d449.8MYC, ESR2, AR, SFTPB, MMP9, MUC1
33sucrose44 11 2411.8CDH1, CHGA, SYP, CTNNB1, SFTPB
34serine449.8TUBA1B, MMP9, CDH1, SFTPB, CTNND1, NKX2-1
35chloramphenicol44 2 1111.8MMP9, FOXM1, MYC, CHGA, MUC1, AR
36dmso449.7MUC1, ENO2, CHGA, MYC, ESR2
37doxorubicin44 49 1111.7MYC, TUBA1B, AR, CDH1, ESR2, CTNNB1
38ribonucleic acid449.7CHGA, MUC1, MYC, SFTPB, MMP9, ACTC1
39cisplatin44 49 59 1112.7CHGA, TUBA1B, CTNNB1, SYP, MYC, MUC1
40vitamin a44 11 2411.6SFTPB, MMP9, CTNNB1, MYC
41glycogen44 2410.6CTNNB1, SYP, TUBA1B, CHGA, ENO2, MYC
42dexamethasone44 49 28 1112.6CTNNB1, NKX2-1, MYC, CDH1, MMP9, ENO2
43cysteine449.5TUBA1B, SFTPB, CTNNB1, SYP, CHGA, ESR2
44testosterone44 59 11 2412.5ESR2, ENO2, ACTC1, MMP9, CDH1, CHGA
45progesterone44 59 28 11 2413.4SFTPB, CTNNB1, AR, NKX2-1, ESR2, ENO2
46calcium44 49 11 2412.2SFTPA1, MUC1, CHGA, SYP, CDH1, ACTC1
47paraffin449.1ESR2, NKX2-1, AR, ENO2, ACTC1, MMP9
48tyrosine449.1SYP, CHGA, MUC1, CDH1, MMP9, ACTC1
49vegf448.9TUBA1B, SFTPB, CTNND1, CTNNB1, AR, MMP9
50retinoic acid44 249.8TUBA1B, SFTPB, FOXM1, NKX2-1, AR, MYC

GO Terms for genes affiliated with Sclerosing Hemangioma

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16Gene Ontology
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Cellular components related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.2AXIN1, CTNNB1
2cell-cell adherens junctionGO:00591310.1CDH1, CTNNB1, CTNND1
3lateral plasma membraneGO:01632810.0AXIN1, CDH1, CTNNB1
4cytoplasmic microtubuleGO:0058819.9TUBA1B, TUBA1A, AXIN1
5catenin complexGO:0163429.9CDH1, CTNNB1

Biological processes related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiation involved in prostate gland developmentGO:06074210.4AR, CTNNB1
2regulation of protein localization to cell surfaceGO:200000810.4CTNNB1, CDH1
3cellular response to indole-3-methanolGO:07168110.4CTNNB1, CDH1
4cytoskeleton-dependent intracellular transportGO:03070510.4TUBA1A, TUBA1B
5prostate gland epithelium morphogenesisGO:06074010.3ESR2, AR
6negative regulation of stress-activated MAPK cascadeGO:03287310.3MYC, FOXM1
7dorsal/ventral axis specificationGO:00995010.3AXIN1, CTNNB1
8epithelial tube branching involved in lung morphogenesisGO:06044110.2NKX2-1, CTNNB1
9canonical Wnt receptor signaling pathwayGO:06007010.2CTNNB1, MYC, AXIN1
10cell-cell adhesionGO:0163379.9CTNND1, CTNNB1, CDH1
11negative regulation of transcription from RNA polymerase II promoterGO:0001229.8ESR2, MYC, NKX2-1, CTNNB1, FOXM1
12positive regulation of transcription, DNA-dependentGO:0458939.7AXIN1, FOXM1, CTNNB1, AR, NKX2-1, MYC
13response to drugGO:0424939.6ACTC1, CDH1, MYC, CTNNB1

Molecular functions related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:01990310.2CDH1, CTNNB1, CTNND1
2beta-catenin bindingGO:00801310.2AR, CDH1, AXIN1
3transcription regulatory region DNA bindingGO:04421210.1FOXM1, CTNNB1, AR, NKX2-1
4structural constituent of cytoskeletonGO:00520010.1SYNM, TUBA1A, TUBA1B
5enzyme bindingGO:01989910.0ESR2, AXIN1, AR, CTNNB1
6I-SMAD bindingGO:0704119.9AXIN1, CTNNB1
7transcription factor bindingGO:0081349.8FOXM1, CTNNB1, AR, MYC
8sequence-specific DNA binding transcription factor activityGO:0037009.6FOXM1, CTNNB1, AR, NKX2-1, MYC, ESR2
9protein bindingGO:0055158.7ESR2, TUBA1B, TUBA1A, FOXM1, CTNND1, CTNNB1

Products for genes affiliated with Sclerosing Hemangioma

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Sources for Sclerosing Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet