MCID: SCL017
MIFTS: 39

Sclerosing Hemangioma malady

Cancer diseases category

Summaries for Sclerosing Hemangioma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Benign fibrous histiocytomas (also known as Dermal dendrocytoma,Dermatofibroma,Fibrous... more...

MalaCards: Sclerosing Hemangioma, also known as cutaneous fibrous histiocytoma, is related to hemangioma and giant cell tumor. An important gene associated with Sclerosing Hemangioma is NKX2-1 (NK2 homeobox 1), and among its related pathways is Immune response Bacterial infections in normal airways. The compounds 2,4-dinitrophenol and whey have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and thyroid.

Aliases & Classifications for Sclerosing Hemangioma

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Sources:
63UMLS, 9Disease Ontology, 11DISEASES, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sclerosing hemangioma 9 11
cutaneous fibrous histiocytoma 63
sclerosing haemangioma 9


External Ids:

Disease Ontology9 DOID:495
SNOMED-CT59 72079004, 134302009

Related Diseases for Sclerosing Hemangioma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Sclerosing Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma31.7SFTPB, ACTC1, NKX2-1
2giant cell tumor30.4MUC1, ACTC1
3adenocarcinoma30.3AXIN1, NKX2-1, MUC1, ACTC1, SYNM, SFTPB
4papillary adenocarcinoma30.2NKX2-1, MUC1
5non-small cell lung carcinoma30.1NKX2-1, SFTPB
6breast cancer30.0NKX2-1, SFTPB, MUC1, ACTC1
7pulmonary sclerosing hemangioma11.0
8thyroiditis10.5
9hemangioma of lung10.3
10fibrous histiocytoma10.2
11familial adenomatous polyposis10.2
12hepatitis10.2
13histiocytoma10.2
14endotheliitis10.2
15pulmonary sequestration10.1
16congenital diaphragmatic hernia10.1SFTPB
17glomus tumor10.1ACTC1
18fibroma10.1
19lymphangioleiomyomatosis10.1
20cavernous hemangioma10.1
21colorectal cancer10.1
22glomangioma10.1
23lung cancer10.1
24mediastinitis10.1
25melanoma10.1
26neuroendocrine tumor10.1
27gigantism10.1
28hemangioendothelioma10.1
29epithelioid hemangioendothelioma10.1
30newborn respiratory distress syndrome10.1SFTPB, NKX2-1
31thymus cancer10.1MUC1, NKX2-1
32large cell carcinoma10.1SFTPB, NKX2-1
33sex cord-gonadal stromal tumor10.1MUC1, NKX2-1
34merkel cell carcinoma10.1NKX2-1, MUC1
35interstitial lung disease10.1NKX2-1, SFTPB
36adenosquamous carcinoma10.0NKX2-1, MUC1
37pulmonary alveolar proteinosis10.0MUC1, SFTPB
38respiratory failure10.0SFTPB, NKX2-1
39spindle cell carcinoma10.0MUC1, ACTC1
40spindle cell sarcoma10.0ACTC1, MUC1
41dermatofibrosarcoma protuberans10.0ACTC1, MUC1
42rhabdoid tumor10.0ACTC1, MUC1
43hemangiopericytoma10.0MUC1, ACTC1
44malignant mixed mullerian tumor10.0MUC1, ACTC1
45tubular adenocarcinoma10.0MUC1, ACTC1
46angiosarcoma10.0ACTC1, MUC1
47malignant peripheral nerve sheath tumor10.0ACTC1, MUC1
48teratoma10.0ACTC1, NKX2-1
49lung benign neoplasm10.0NKX2-1, SFTPB
50mucoepidermoid carcinoma10.0MUC1, ACTC1

Graphical network of the top 20 diseases related to Sclerosing Hemangioma:



Diseases related to sclerosing hemangioma

Symptoms for Sclerosing Hemangioma

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Drugs & Therapeutics for Sclerosing Hemangioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sclerosing Hemangioma

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Anatomical Context for Sclerosing Hemangioma

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34MalaCards
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MalaCards organs/tissues related to Sclerosing Hemangioma:

34
Lung, Skin, Thyroid, Lymph node, Liver, Endothelial, Tongue, Breast, Kidney, Fetal lung

Animal Models for Sclerosing Hemangioma or affiliated genes

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Publications for Sclerosing Hemangioma

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53PubMed
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Articles related to Sclerosing Hemangioma:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression. (23910931)
2013
2
Pneumocytoma (formerly known as sclerosing hemangioma of the lung): a rare cause of chest pain. (23380035)
2013
3
A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report. (23714181)
2013
4
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). (23290153)
2013
5
Sclerosing hemangioma of the lung manifesting as a cystic lesion with an air-fluid level. (22832056)
2012
6
Treatment of 28 patients with sclerosing hemangioma (SH) of the lung. (22515818)
2012
7
Pulmonary sclerosing hemangioma: pitfalls in management. (21471259)
2011
8
Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. (21649526)
2011
9
A case of pulmonary sclerosing hemangioma surrounded by giant cystic change on high-resolution computed tomography. (20634757)
2011
10
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. (21645337)
2011
11
A case of sclerosing hemangioma evaluated with diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography. (21057447)
2010
12
Sclerosing hemangioma of the lung. (19415961)
2009
13
Respiratory arrest caused by endobronchial sclerosing hemangioma of the left main bronchus. (23168550)
2009
14
Sclerosing hemangioma with an air halo. (19026830)
2008
15
Endobronchial sclerosing hemangioma: a rare presentation of a parenchymal tumor. (18245708)
2008
16
Pulmonary sclerosing hemangioma manifesting as a nodule with irregular air clefts on high-resolution CT. (17579131)
2007
17
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. (17383052)
2007
18
Sclerosing hemangioma of the lung: a benign tumour with potential for malignancy? (17095978)
2006
19
Bilateral multiple pulmonary sclerosing hemangioma. (15828298)
2005
20
Sclerosing hemangioma. (15954523)
2005
21
Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. (15201499)
2004
22
Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. (15138814)
2004
23
Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. (15116333)
2004
24
Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. (12653576)
2003
25
Biologic significance of thyroid transcription factor-1 and surfactant protein expression in pulmonary sclerosing hemangioma]. (14720435)
2003
26
Pulmonary sclerosing hemangioma with lymph node metastases. (14571291)
2003
27
Unilateral progressive multiple sclerosing hemangioma in a young female successfully treated by pneumonectomy: report of a case. (12222919)
2002
28
The expression of thyroid transcription factor-1 in pulmonary sclerosing hemangioma and a further investigation on histogenesis of the tumor]. (11955335)
2002
29
Sclerosing hemangioma of lung: A close cytologic mimicker of pulmonary adenocarcinoma. (11747223)
2001
30
A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. (10716159)
2000
31
Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. (9546367)
1998
32
Pulmonary sclerosing hemangioma in a woman with multiple uterine fibromas, cysts to thyroid and kidney. (8702253)
1996
33
Positive expression of c-myc and p53 products in two cases of pulmonary sclerosing hemangioma]. (8821986)
1995
34
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
35
Sclerosing hemangioma of the lung. Granulomatous variant. (7944888)
1994
36
Sclerosing hemangioma of the lung: pathological study and enzyme immunoassay for estrogen and progesterone receptors. (8237370)
1993
37
Pulmonary sclerosing hemangioma of the lung. A type II pneumocytoma by immunohistochemical and immunoelectron microscopic studies. (2548701)
1989
38
Sclerosing hemangioma of the lung. An immunohistochemical study of intermediate filaments and endothelial markers. (2537067)
1989
39
So-called sclerosing hemangioma of the lung. An immunohistochemical, histochemical and ultrastructural study. (2463730)
1988
40
Sclerosing hemangioma of the lung. An epithelial tumor composed of immunohistochemically heterogenous cells. (2823596)
1987
41
Sclerosing hemangioma of the lung. Immunohistochemical demonstration of mesenchymal origin using antibodies to tissue-specific intermediate filaments. (3021315)
1986
42
Is sclerosing hemangioma of lung an alveolar mixed tumour? (6310472)
1983
43
Pulmonary sclerosing hemangioma: sometimes a form of pulmonary hamartoma. (7089615)
1982
44
Sclerosing hemangioma of the lung: report of a case with an ultrastructural study. (6251145)
1980
45
Case report 104. Sclerosing hemangioma of right seventh rib. (231328)
1979
46
The air meniscus sign in sclerosing hemangioma of the lung. (208101)
1978
47
Sclerosing hemangioma of the tongue: report of case. (1054080)
1975
48
Fibrous histiocytoma of the lung (sclerosing hemangioma variant?). (4362113)
1974
49
Non-neoplastic sclerotic pulmonary lesion (sclerosing hemangioma). Report of a case. (4331028)
1971
50
Sclerosing hemangioma of the lung. (13667023)
1959

Variations for Sclerosing Hemangioma

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Expression for genes affiliated with Sclerosing Hemangioma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sclerosing Hemangioma

Search GEO for disease gene expression data for Sclerosing Hemangioma.

Pathways for genes affiliated with Sclerosing Hemangioma

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51PathCards, 61Thomson Reuters
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Pathways related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5MUC1, SFTPA1

Compounds for genes affiliated with Sclerosing Hemangioma

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
12,4-dinitrophenol469.9NKX2-1, SFTPB
2whey469.7MUC1, SFTPB
3s 100469.6ACTC1, MUC1
4methanol46 2510.6SFTPB, ACTC1
5reticulin469.6MUC1, ACTC1
6biotin46 25 1211.4ACTC1, MUC1
7gold469.4SFTPB, MUC1
8mucicarmine469.3NKX2-1, ACTC1, MUC1
9b 723469.3NKX2-1, ACTC1, MUC1
10hematoxylin469.3NKX2-1, ACTC1, MUC1
11cyclic amp46 2510.3NKX2-1, MUC1, SFTPB
12formaldehyde46 2510.2MUC1, ACTC1, NKX2-1
13progesterone46 30 62 25 1213.2ACTC1, MUC1, SFTPB
14vegf468.9ACTC1, MUC1, SFTPB
15ribonucleic acid468.8SFTPB, MUC1, ACTC1, NKX2-1
16threonine468.8NKX2-1, MUC1, SFTPB
17paraffin468.8SFTPB, MUC1, ACTC1, NKX2-1
18dexamethasone46 52 30 1211.8NKX2-1, ACTC1, MUC1, SFTPB
19retinoic acid46 259.7NKX2-1, ACTC1, MUC1, SFTPB
20tyrosine468.6SFTPB, MUC1, ACTC1, NKX2-1
21calcium46 52 25 1211.5ACTC1, MUC1, SFTPA1, SFTPB

GO Terms for genes affiliated with Sclerosing Hemangioma

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17Gene Ontology
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Biological processes related to Sclerosing Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.6SFTPA1, SFTPB

Products for genes affiliated with Sclerosing Hemangioma

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Sources for Sclerosing Hemangioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet