MCID: SCL018
MIFTS: 56

Scoliosis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Scoliosis

MalaCards integrated aliases for Scoliosis:

Name: Scoliosis 12 72 28 40 41 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060249
ICD10 32 M41 M41.9
MeSH 41 D012600
NCIt 46 C78603
SNOMED-CT 64 298382003 36773001
UMLS 69 C0036439

Summaries for Scoliosis

MedlinePlus : 40 Scoliosis causes a sideways curve of your backbone, or spine. These curves are often S- or C-shaped. Scoliosis is most common in late childhood and the early teens, when children grow fast. Girls are more likely to have it than boys. It can run in families. Symptoms include leaning to one side and having uneven shoulders and hips. Sometimes it is easy to notice, but not always. Children may get screening for scoliosis at school or during a checkup. If it looks like there is a problem, your doctor will use your medical and family history, a physical exam, and imaging tests to make a diagnosis. Treatment depends on your age, how much more you're likely to grow, how much curving there is, and whether the curve is temporary or permanent. People with mild scoliosis might only need checkups to see if the curve is getting worse. Others might need to wear a brace or have surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Scoliosis is related to idiopathic scoliosis and spondylocostal dysostosis 3, autosomal recessive. An important gene associated with Scoliosis is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Thrombin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are behavior/neurological and cellular

Disease Ontology : 12 A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine.

Wikipedia : 72 Scoliosis is a medical condition in which a person\'s spine has a sideways curve. The curve is usually... more...

Related Diseases for Scoliosis

Diseases in the Scoliosis family:

Infantile Scoliosis

Diseases related to Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
# Related Disease Score Top Affiliating Genes
1 idiopathic scoliosis 33.7 BNC2 CHD7 COL1A2 FBN1 IS1 SNTG1
2 spondylocostal dysostosis 3, autosomal recessive 32.5 DLL3 MESP2
3 marfan syndrome 32.1 COL1A2 FBN1 FBN2
4 spondylocostal dysostosis 1, autosomal recessive 31.6 DLL3 MESP2
5 stiff skin syndrome 31.5 COL1A2 FBN1
6 brittle bone disorder 30.2 COL1A1 COL1A2 COL2A1 FGFR3
7 pectus excavatum 30.1 FBN1 FGFR3
8 dysostosis 29.9 DLL3 EXT2 FGFR3 MESP2
9 spondyloepiphyseal dysplasia congenita 29.8 COL1A1 COL1A2 COL2A1 FGFR3
10 spondyloepiphyseal dysplasia with congenital joint dislocations 29.4 COL2A1 FGFR3
11 scoliosis, isolated 1 12.4
12 horizontal gaze palsy with progressive scoliosis 12.4
13 gaze palsy, familial horizontal, with progressive scoliosis, 1 12.2
14 radioulnar synostosis-microcephaly-scoliosis syndrome 12.1
15 scoliosis, isolated 3 12.1
16 scoliosis, isolated 4 12.1
17 scoliosis, isolated 5 12.1
18 seizures, scoliosis, and macrocephaly syndrome 12.1
19 acrodysplasia scoliosis 12.1
20 scoliosis, isolated 2 12.1
21 gaze palsy, familial horizontal, with progressive scoliosis, 2 12.0
22 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 12.0
23 brachydactyly, type a1, with short stature, scoliosis, microcephaly, ptosis, hearing loss, and mental retardation 12.0
24 infantile scoliosis 11.9
25 scoliosis with unilateral unsegmented bar 11.9
26 spondylocarpotarsal synostosis syndrome 11.9
27 dislocated elbows, bowed tibias, scoliosis, deafness, cataract, microcephaly, and mental retardation 11.9
28 rhizomelic dysplasia, scoliosis, and retinitis pigmentosa 11.8
29 scoliosis, arachnodactyly, and blindness 11.8
30 opthalmoplegia progressive external scoliosis 11.8
31 syncamptodactyly scoliosis 11.8
32 duane anomaly-myopathy-scoliosis syndrome 11.8
33 steel syndrome 11.7
34 macs syndrome 11.6
35 camptodactyly, tall stature, and hearing loss syndrome 11.4
36 shprintzen omphalocele syndrome 11.4
37 arthrogryposis, distal, type 4 11.4
38 epiphyseal chondrodysplasia, miura type 11.4
39 pilotto syndrome 11.3
40 friedreich ataxia 1 11.3
41 spondylocostal dysostosis 5 11.3
42 central core disease of muscle 11.1
43 multiple pterygium syndrome, escobar variant 11.1
44 proximal spinal muscular atrophy 11.1
45 larsen syndrome 11.1
46 rigid spine muscular dystrophy 1 11.1
47 superior mesenteric artery syndrome 11.0
48 dental anomalies and short stature 11.0
49 rett syndrome 11.0
50 spinal muscular atrophy 11.0

Graphical network of the top 20 diseases related to Scoliosis:



Diseases related to Scoliosis

Symptoms & Phenotypes for Scoliosis

MGI Mouse Phenotypes related to Scoliosis:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 CHD7 COL1A1 COL1A2 COL2A1 DCC DLL3
2 cellular MP:0005384 10.25 CHD7 COL1A1 COL1A2 COL2A1 DCC FBN1
3 mortality/aging MP:0010768 10.21 BNC2 CHD7 COL1A1 COL1A2 COL2A1 DCC
4 growth/size/body region MP:0005378 10.2 BNC2 CHD7 COL1A1 COL1A2 COL2A1 DLL3
5 embryo MP:0005380 10.08 CHD7 COL1A1 COL2A1 DLL3 EXT2 FBN1
6 limbs/digits/tail MP:0005371 10.06 CHD7 COL1A1 COL1A2 COL2A1 DLL3 FBN1
7 craniofacial MP:0005382 10.04 DLL3 FBN1 FGFR3 BNC2 CHD7 COL1A1
8 nervous system MP:0003631 10 CHD7 COL1A1 COL2A1 DCC DLL3 FBN1
9 hearing/vestibular/ear MP:0005377 9.91 CHD7 COL1A1 COL2A1 DLL3 FGFR3 ROBO3
10 muscle MP:0005369 9.87 CHD7 COL1A1 COL1A2 DLL3 FBN1 FBN2
11 respiratory system MP:0005388 9.76 FGFR3 ROBO3 CHD7 COL1A1 COL2A1 DCC
12 skeleton MP:0005390 9.73 BNC2 CHD7 COL1A1 COL1A2 COL2A1 DLL3
13 vision/eye MP:0005391 9.23 CHD7 COL1A1 COL2A1 DCC DLL3 FBN2

Drugs & Therapeutics for Scoliosis

Drugs for Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2 1197-18-8 5526
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Aminocaproic Acid Approved, Investigational Phase 4,Phase 1 60-32-2 564
9
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
10
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
11
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1 2078-54-8 4943
12
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
13
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
14
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
15
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
16
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Menthol Approved Phase 4 2216-51-5 16666
19
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
20
Iodine Approved, Investigational Phase 4 7553-56-2 807
21
Povidone Approved Phase 4 9003-39-8
22
Povidone-iodine Approved Phase 4 25655-41-8
23
Acetaminophen Approved Phase 4 103-90-2 1983
24
Cyclobenzaprine Approved Phase 4 303-53-7 2895
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
27 Coagulants Phase 4,Phase 3,Phase 1,Phase 2
28 Hemostatics Phase 4,Phase 3,Phase 1,Phase 2
29 Antifibrinolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Bone Density Conservation Agents Phase 4,Phase 3
31
Cobalt Phase 4 7440-48-4 104729
32 Micronutrients Phase 4,Phase 3
33 Trace Elements Phase 4,Phase 3
34 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
35 Anesthetics, Local Phase 4
36 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
39 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Phase 1
40 Narcotics Phase 4,Phase 3,Phase 2,Phase 1
41 Adjuvants, Anesthesia Phase 4
42 Adrenergic Agents Phase 4,Phase 1
43 Adrenergic Agonists Phase 4,Phase 1
44 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 1
45 Adrenergic alpha-Agonists Phase 4,Phase 1
46 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
47 Anesthetics, General Phase 4,Phase 1,Phase 2
48 Anesthetics, Intravenous Phase 4,Phase 2,Phase 1
49 Anti-Anxiety Agents Phase 4,Phase 3
50 GABA Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 248)

# Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109 Phase 4
3 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
4 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
5 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
6 Effects of Dexmedetomidine on the Postoperative Experience in Children Completed NCT01748630 Phase 4 dexmedetomidine;Midazolam;fentanyl
7 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
8 Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy Completed NCT01882400 Phase 4 Bisphosphonate treatment
9 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
10 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
11 The Use of Intraoperative Intrathecal Morphine Versus Epidural Extended Release Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion Completed NCT00880607 Phase 4 DepoDur™
12 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Recruiting NCT02206685 Phase 4 Methadone;Normal Saline
13 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
14 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
15 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin Recruiting NCT01977937 Phase 4 Gabapentin;Simple Syrup
16 Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery Recruiting NCT02527512 Phase 4 Povidone-Iodine
17 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
18 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Active, not recruiting NCT02188576 Phase 4 high dose TXA;Low dose TXA
19 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
20 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
21 Posterior Spinal Fusion With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
22 Comparison of Actifuse ABX and Local Bone in Spinal Surgery Terminated NCT01852747 Phase 4
23 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Unknown status NCT02285621 Phase 3
24 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
25 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
26 Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery Completed NCT00737997 Phase 3 Morphine
27 IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction Completed NCT01205256 Phase 3 methadone
28 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
29 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
30 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
31 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
32 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
33 Amantadine Sulphate Usage in Spine Deformities Corrective Surgeries Patients Recruiting NCT03178708 Phase 2, Phase 3 Group A amantadine sulfate
34 Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease Enrolling by invitation NCT02496364 Phase 3 Placebo (Topical);Placebo (Intravenous);Tranexamic Acid (Topical);Tranexamic Acid (Intravenous)
35 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
36 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
37 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
38 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
39 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
40 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
41 Phase II Clinical Study of Thalidomide in the Treatment of Ankylosing Spondylitis Completed NCT02201043 Phase 2 Thalidomide 150mg;Thalidomide 100mg;Placebo
42 The Use of Dermabond Versus Standard Staple for Wound Closure in Children With Neuromuscular Scoliosis Undergoing Spinal Deformity Correction Surgery Recruiting NCT01135940 Phase 2
43 Value of 3D Modeling in Spine Surgery Recruiting NCT02771899 Phase 2
44 Safety and Efficacy Study of Spinal Tethering Recruiting NCT02897453 Phase 2
45 Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion Recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
46 Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation Recruiting NCT02388165 Phase 2
47 Non-Idiopathic Scoliosis Treated With Tranexamic Acid Suspended NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
48 Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) Syndrome Terminated NCT00527878 Phase 2 Ranitidine;Placebo
49 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1
50 Influence of Leg Length Discrepancy on the Spinal Shape and Biomechanics in Functional and Idiopathic Scoliosis Patients Completed NCT00155545 Phase 1

Search NIH Clinical Center for Scoliosis

Cochrane evidence based reviews: scoliosis

Genetic Tests for Scoliosis

Genetic tests related to Scoliosis:

# Genetic test Affiliating Genes
1 Scoliosis 28

Anatomical Context for Scoliosis

MalaCards organs/tissues related to Scoliosis:

38
Bone, Testes, Skin, Spinal Cord, Brain, Lung, Skeletal Muscle

Publications for Scoliosis

Articles related to Scoliosis:

(show top 50) (show all 888)
# Title Authors Year
1
Central core disease with scoliosis for congenital hip dislocation surgery: An anaesthetic demur. ( 29416159 )
2018
2
Growth Friendly Surgery and Serial Cast Correction in the Treatment of Early-onset Scoliosis for Patients With Prader-Willi Syndrome. ( 29401073 )
2018
3
Variation in Adolescent Idiopathic Scoliosis Surgery: Implications for Improving Healthcare Value. ( 29426688 )
2018
4
Bone Mineral Density After Spinal Fusion Surgery for Adolescent Idiopathic Scoliosis at a Minimum 20-Year Follow-up. ( 29413740 )
2018
5
Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389797 )
2018
6
Increased PT/SS may play an important role in the pathogenesis of lumbar spondylolisthesis with degenerative lumbar scoliosis. ( 29358108 )
2018
7
Minimally Invasive Surgery for Neuromuscular Scoliosis: Results and Complications in a Series of one hundred Patients. ( 29419720 )
2018
8
Supplementary Addendum to "Radiation dose of digital radiography (DR) versus micro-dose x-ray (EOS) on patients with adolescent idiopathic scoliosis: 2016 SOSORT- IRSSD "John Sevastic Award" Winner in Imaging Research". ( 29435497 )
2018
9
Ethnic Variation in Satisfaction and Appearance Concerns in Adolescents With Idiopathic Scoliosis Undergoing Posterior Spinal Fusion With Instrumentation. ( 29413737 )
2018
10
Prevalence and impact of low body mass index on outcomes in patients with adolescent idiopathic scoliosis: a systematic review. ( 29434317 )
2018
11
Evidence-Based Thresholds for the Volume-Value Relationship in Adolescent Idiopathic Scoliosis: Outcomes and Economies of Scale. ( 29413738 )
2018
12
Who Needs a Pediatric Intensive Care Unit After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis? ( 29413735 )
2018
13
LETTER TO THE EDITOR CONCERNING: Effectiveness of the Rigo ChA-neau versus Boston-style orthoses for adolescent idiopathicscoliosis: a retrospective study, by Minsk MK, Venuti KD, Daumit GL, Sponseller PD. Scoliosis Spinal Disord. 2017 Mar 20;12:7. ( 29435498 )
2018
14
Defining and Correcting Asymmetry in Isolated Unilateral Frontosphenoidal Synostosis: Differences in Orbital Shape, Facial Scoliosis, and Skullbase Twist Compared to Unilateral Coronal Synostosis. ( 29065043 )
2018
15
Additional Risk Factors for Adding-On After Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis: Implication of Lowest Instrumented Vertebra Angle and Lumbosacral Takeoff. ( 29413739 )
2018
16
Vertebral Axial Asymmetry in Adolescent Idiopathic Scoliosis. ( 29413732 )
2018
17
Incidence, Risk Factors, and Evolution of Proximal Junctional Kyphosis After Posterior Hemivertebra Resection and Short Fusion in Young Children With Congenital Scoliosis. ( 29419719 )
2018
18
Increased Radiation but No Benefits in Pedicle Screw Accuracy With Navigation versus a Freehand Technique in Scoliosis Surgery. ( 29432262 )
2018
19
Novel Mutations in SCN4A Gene Cause Myotonia Congenita with Scoliosis. ( 29451154 )
2018
20
Can bracing help adults with chronic back pain and scoliosis? Short-term results from a pilot study. ( 29446692 )
2018
21
2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. ( 29435499 )
2018
22
Circulating miRNAs as diagnostic biomarkers for adolescent idiopathic scoliosis. ( 29422531 )
2018
23
CORR InsightsAr: Curve Progression in Adolescent Idiopathic Scoliosis Does Not Match Skeletal Growth. ( 29389798 )
2018
24
Torsion bottle, a very simple, reliable, and cheap tool for a basic scoliosis screening. ( 29445775 )
2018
25
Effect of Posterior Fossa Decompression for Chiari Malformation-I on Scoliosis. ( 29298440 )
2018
26
Horizontal Gaze Palsy With Progressive Scoliosis: Two Novel ROBO3 Mutations in a Compound Heterozygous Sporadic Case. ( 29215389 )
2018
27
Trunk rotation alters postural sway but not gait in female children and early adolescents: Results from a school-based screening for scoliosis. ( 29413801 )
2018
28
Predictors of Deterioration in Sagittal Balance Following Long Fusion Arthrodesis to L5 in Patients with Adult Scoliosis. ( 29442100 )
2018
29
Current Evidence Regarding the Diagnostic Methods for Pediatric Lumbar Spondylolisthesis: A Report From the Scoliosis Research Society Evidence Based Medicine Committee. ( 29413742 )
2018
30
Estrogen receptor gene polymorphism in patients with degenerative lumbar scoliosis. ( 27399961 )
2017
31
A novel TRAPPC11 mutation in two Turkish families associated with cerebral atrophy, global retardation, scoliosis, achalasia and alacrima. ( 27707803 )
2017
32
A novel mutation of ROBO3 in horizontal gaze palsy with progressive scoliosis. ( 27267957 )
2017
33
Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis-a guide to reference values using serial imaging. ( 28065817 )
2017
34
Multimodal intraoperative neuromonitoring in scoliosis surgery: A two-year prospective analysis in a single centre. ( 28084243 )
2017
35
Accelerated Discharge Protocol for Posterior Spinal Fusion Patients With Adolescent Idiopathic Scoliosis Decreases Hospital Postoperative Charges 22. ( 28072636 )
2017
36
Anterior release may not be necessary for idiopathic scoliosis with large curve of more than 75A^ and flexibility less than 25. ( 28939170 )
2017
37
Analysing the change of sagittal balance in patients with Lenke 5 idiopathic scoliosis. ( 28889983 )
2017
38
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
39
Current Evidence Regarding the Treatment of Pediatric Lumbar Spondylolisthesis: A Report From the Scoliosis Research Society Evidence Based Medicine Committee. ( 28882346 )
2017
40
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
41
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
42
Diffusion Tensor Imaging of Lumbar Vertebras in Female Adolescent Idiopathic Scoliosis: Initial Findings. ( 28937482 )
2017
43
Is the Superior Articular Process a Reliable Landmark for Determining the Transverse Plane Angulation of Thoracic Pedicles in Patients With Adolescent Idiopathic Scoliosis? ( 28038694 )
2017
44
Differential Rod Contouring is Essential for Improving Vertebral Rotation in Patients With Adolescent Idiopathic Scoliosis: Thoracic Curves Assessed With Intraoperative CT. ( 28953709 )
2017
45
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
46
Progressive Infantile Scoliosis Managed With Osteopathic Manipulative Treatment. ( 28846126 )
2017
47
A Comparative Study of Sagittal Balance in Patients with Neuromuscular Scoliosis. ( 28954007 )
2017
48
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
49
Effects of Nuss procedure on thoracic scoliosis in patients with pectus excavatum. ( 29268389 )
2017
50
The Role of Correction in the Conservative Treatment of Adolescent Idiopathic Scoliosis. ( 29399228 )
2017

Variations for Scoliosis

ClinVar genetic disease variations for Scoliosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NSD1 NM_022455.4(NSD1): c.6050G> A (p.Arg2017Gln) single nucleotide variant Pathogenic/Likely pathogenic rs587784177 GRCh38 Chromosome 5, 177283827: 177283827
2 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
3 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
4 FBN1 NM_000138.4(FBN1): c.6800A> T (p.Asn2267Ile) single nucleotide variant Pathogenic rs1057518812 GRCh38 Chromosome 15, 48430742: 48430742

Expression for Scoliosis

Search GEO for disease gene expression data for Scoliosis.

Pathways for Scoliosis

GO Terms for Scoliosis

Cellular components related to Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 COL1A1 COL1A2 COL2A1 FBN1
2 extracellular matrix GO:0031012 9.55 COL1A1 COL1A2 COL2A1 FBN1 FBN2
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1
4 proteinaceous extracellular matrix GO:0005578 9.35 COL1A1 COL1A2 COL2A1 FBN1 FBN2
5 microfibril GO:0001527 9.26 FBN1 FBN2
6 collagen type I trimer GO:0005584 8.62 COL1A1 COL1A2

Biological processes related to Scoliosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.77 CHD7 COL1A1 COL2A1
2 ossification GO:0001503 9.75 COL1A1 COL2A1 EXT2
3 palate development GO:0060021 9.73 BNC2 CHD7 COL2A1
4 camera-type eye development GO:0043010 9.7 CHD7 FBN1 FBN2
5 collagen catabolic process GO:0030574 9.69 COL1A1 COL1A2 COL2A1
6 blood vessel development GO:0001568 9.61 CHD7 COL1A1 COL1A2
7 limb morphogenesis GO:0035108 9.58 COL2A1 FBN2
8 heart morphogenesis GO:0003007 9.58 CHD7 COL2A1 MESP2
9 protein heterotrimerization GO:0070208 9.57 COL1A1 COL1A2
10 embryonic eye morphogenesis GO:0048048 9.55 FBN1 FBN2
11 skin morphogenesis GO:0043589 9.54 COL1A1 COL1A2
12 collagen fibril organization GO:0030199 9.54 COL1A1 COL1A2 COL2A1
13 bone trabecula formation GO:0060346 9.49 COL1A1 FBN2
14 endochondral bone growth GO:0003416 9.48 BNC2 FGFR3
15 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.46 COL1A1 COL2A1
16 extracellular matrix organization GO:0030198 9.35 COL1A1 COL1A2 COL2A1 FBN1 FBN2
17 endochondral ossification GO:0001958 9.33 COL1A1 COL2A1 FGFR3
18 regulation of cellular response to growth factor stimulus GO:0090287 9.32 FBN1 FBN2
19 sequestering of TGFbeta in extracellular matrix GO:0035583 9.26 FBN1 FBN2
20 skeletal system development GO:0001501 9.17 CHD7 COL1A1 COL1A2 COL2A1 DLL3 FBN1

Molecular functions related to Scoliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 9.26 DLL3 MEGF10
2 extracellular matrix constituent conferring elasticity GO:0030023 9.16 FBN1 FBN2
3 platelet-derived growth factor binding GO:0048407 9.13 COL1A1 COL1A2 COL2A1
4 extracellular matrix structural constituent GO:0005201 9.02 COL1A1 COL1A2 COL2A1 FBN1 FBN2

Sources for Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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