MCID: SCL018
MIFTS: 56

Scoliosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Scoliosis

MalaCards integrated aliases for Scoliosis:

Name: Scoliosis 12 29 41 42 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060249
ICD10 33 M41 M41.9
MeSH 42 D012600
NCIt 47 C78603
SNOMED-CT 64 298382003 36773001
UMLS 69 C0036439

Summaries for Scoliosis

MedlinePlus : 41 scoliosis causes a sideways curve of your backbone, or spine. these curves are often s- or c-shaped. scoliosis is most common in late childhood and the early teens, when children grow fast. girls are more likely to have it than boys. it can run in families. symptoms include leaning to one side and having uneven shoulders and hips. sometimes it is easy to notice, but not always. children may get screening for scoliosis at school or during a checkup. if it looks like there is a problem, your doctor will use your medical and family history, a physical exam, and imaging tests to make a diagnosis. treatment depends on your age, how much more you're likely to grow, how much curving there is, and whether the curve is temporary or permanent. people with mild scoliosis might only need checkups to see if the curve is getting worse. others might need to wear a brace or have surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Scoliosis is related to osteogenesis imperfecta, type iv and horizontal gaze palsy with progressive scoliosis. An important gene associated with Scoliosis is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Thrombin and Aminocaproic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine.

Wikipedia : 72 Scoliosis is a medical condition in which a person\'s spine has a sideways curve. The curve is usually... more...

Related Diseases for Scoliosis

Diseases in the Scoliosis family:

Infantile Scoliosis

Diseases related to Scoliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 389)
id Related Disease Score Top Affiliating Genes
1 osteogenesis imperfecta, type iv 31.9 COL1A1 COL1A2
2 horizontal gaze palsy with progressive scoliosis 12.3
3 adolescent idiopathic scoliosis 12.2
4 idiopathic scoliosis 12.1
5 seizures, scoliosis, and macrocephaly syndrome 12.0
6 scoliosis, isolated 3 12.0
7 macrocephaly, alopecia, cutis laxa, and scoliosis 12.0
8 gaze palsy, familial horizontal, with progressive scoliosis, 1 12.0
9 acrodysplasia scoliosis 12.0
10 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 12.0
11 infantile scoliosis 11.8
12 scoliosis with unilateral unsegmented bar 11.8
13 scoliosis, arachnodactyly, and blindness 11.7
14 opthalmoplegia progressive external scoliosis 11.7
15 gaze palsy, familial horizontal, with progressive scoliosis, 2 11.7
16 syncamptodactyly scoliosis 11.7
17 duane anomaly-myopathy-scoliosis syndrome 11.7
18 rhizomelic dysplasia, scoliosis, and retinitis pigmentosa 11.7
19 spondylocarpotarsal synostosis syndrome 11.6
20 steel syndrome 11.6
21 catshl syndrome 11.3
22 epiphyseal chondrodysplasia, miura type 11.3
23 arthrogryposis, distal, type 4 11.2
24 pilotto syndrome 11.2
25 shprintzen omphalocele syndrome 11.2
26 friedreich ataxia 11.2
27 spondylocostal dysostosis 5 11.1
28 rett syndrome 11.0
29 marfan syndrome 11.0
30 congenital erosive and vesicular dermatosis 11.0 COL1A1 COL1A2
31 central core disease 11.0
32 proximal spinal muscular atrophy 11.0
33 larsen syndrome 10.9
34 escobar syndrome 10.9
35 cln12 disease 10.9 COL1A1 COL1A2
36 carbonic anhydrase va deficiency 10.9 COL1A1 COL1A2
37 prpf3-related retinitis pigmentosa 10.9 COL1A1 COL1A2
38 superior mesenteric artery syndrome 10.9
39 dental anomalies and short stature 10.9
40 pens syndrome 10.9 COL1A1 COL1A2
41 spinal muscular atrophy 10.9
42 duchenne muscular dystrophy 10.9
43 pfn1-related amyotrophic lateral sclerosis 10.9 COL1A1 COL1A2
44 spinal stenosis 10.9
45 brachyolmia type 3 10.9
46 klippel-feil syndrome 10.8
47 epilepsy with neurodevelopmental defects 10.8 COL1A1 COL1A2
48 deafness, autosomal recessive 91 10.8 COL1A1 COL1A2
49 neurofibromatosis, type 1 10.8
50 tethered cord syndrome 10.8

Graphical network of the top 20 diseases related to Scoliosis:



Diseases related to Scoliosis

Symptoms & Phenotypes for Scoliosis

MGI Mouse Phenotypes related to Scoliosis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 CHD7 COL1A1 COL1A2 COL2A1 DLL3 FBN1
2 growth/size/body region MP:0005378 10.17 MESP2 RIMS2 BNC2 CHD7 COL1A1 COL1A2
3 mortality/aging MP:0010768 10.13 CHD7 COL1A1 COL1A2 COL2A1 DLL3 EXT2
4 embryo MP:0005380 10.06 EXT2 FBN1 MESP2 ROBO3 CHD7 COL1A1
5 craniofacial MP:0005382 10.02 BNC2 CHD7 COL1A1 COL2A1 DLL3 FBN1
6 limbs/digits/tail MP:0005371 10.02 CHD7 COL1A1 COL1A2 COL2A1 DLL3 FBN1
7 hearing/vestibular/ear MP:0005377 9.88 CHD7 COL1A1 COL2A1 DLL3 FGFR3 ROBO3
8 nervous system MP:0003631 9.85 CHD7 COL1A1 COL2A1 DLL3 FBN1 FGFR3
9 muscle MP:0005369 9.8 CHD7 COL1A1 COL1A2 DLL3 FBN1 FBN2
10 respiratory system MP:0005388 9.5 COL1A1 COL2A1 FBN1 FBN2 FGFR3 ROBO3
11 skeleton MP:0005390 9.4 BNC2 CHD7 COL1A1 COL1A2 COL2A1 DLL3

Drugs & Therapeutics for Scoliosis

Drugs for Scoliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved Phase 4
2
Aminocaproic Acid Approved, Investigational Phase 4,Phase 1 60-32-2 564
3
Tranexamic Acid Approved Phase 4,Phase 3,Phase 1,Phase 2 1197-18-8 5526
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
6
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
9
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
10
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
11
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1 2078-54-8 4943
12
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
13
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
14
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
15
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
16
Ibuprofen Approved Phase 4 15687-27-1 3672
17
Menthol Approved Phase 4 2216-51-5 16666
18
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
19
Povidone Approved Phase 4 9003-39-8
20 Povidone-iodine Approved Phase 4 25655-41-8
21
Acetaminophen Approved Phase 4 103-90-2 1983
22
Cyclobenzaprine Approved Phase 4 303-53-7 2895
23
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
25
gamma-Aminobutyric acid Investigational Phase 4,Phase 3 56-12-2 119
26
Iodine Investigational Phase 4 7553-56-2 807
27 Coagulants Phase 4,Phase 3,Phase 1,Phase 2
28 Hemostatics Phase 4,Phase 3,Phase 1,Phase 2
29 Antifibrinolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
31 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
32
Cobalt Phase 4 7440-48-4 104729
33 Micronutrients Phase 4,Phase 3
34 Trace Elements Phase 4,Phase 3
35 Anesthetics, Local Phase 4
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
38 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Phase 1
39 Narcotics Phase 4,Phase 3,Phase 2,Phase 1
40 Adjuvants, Anesthesia Phase 4
41 Adrenergic Agents Phase 4,Phase 1
42 Adrenergic Agonists Phase 4,Phase 1
43 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 1
44 Adrenergic alpha-Agonists Phase 4,Phase 1
45 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
46 Anesthetics, General Phase 4,Phase 1,Phase 2
47 Anesthetics, Intravenous Phase 4,Phase 2,Phase 1
48 Anti-Anxiety Agents Phase 4,Phase 3
49 GABA Agents Phase 4,Phase 3
50 GABA Modulators Phase 4

Interventional clinical trials:

(show top 50) (show all 234)

id Name Status NCT ID Phase Drugs
1 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
2 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Unknown status NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
3 Scoliosis Surgery Using the PASS® LP System Completed NCT01019109 Phase 4
4 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
5 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
6 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
7 Effects of Dexmedetomidine on the Postoperative Experience in Children Completed NCT01748630 Phase 4 dexmedetomidine;Midazolam;fentanyl
8 Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy Completed NCT01882400 Phase 4 Bisphosphonate treatment
9 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
10 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
11 The Use of Intraoperative Intrathecal Morphine Versus Epidural Extended Release Morphine for Postoperative Pain Control in Pediatric Patients Undergoing Posterior Spinal Fusion Completed NCT00880607 Phase 4 DepoDur™
12 Wound Vac Bandage Comparison After Spinal Fusion Recruiting NCT03000010 Phase 4
13 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Recruiting NCT02206685 Phase 4 Methadone;Normal Saline
14 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
15 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
16 Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin Recruiting NCT01977937 Phase 4 Gabapentin;Simple Syrup
17 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Recruiting NCT02188576 Phase 4 high dose TXA;Low dose TXA
18 Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery Recruiting NCT02527512 Phase 4 Povidone-Iodine
19 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Active, not recruiting NCT02651324 Phase 4 Ketamine
20 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
21 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
22 Posterior Spinal Fusion With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
23 Comparison of Actifuse ABX and Local Bone in Spinal Surgery Terminated NCT01852747 Phase 4
24 Analgesic Effects of Gabapentin After Scoliosis Surgery in Children Completed NCT00684112 Phase 3 Gabapentin;Placebo
25 Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery Completed NCT00737997 Phase 3 Morphine
26 Calcium + Vitamin D Supplementation for Low Bone Mass in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01103115 Phase 3
27 IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction Completed NCT01205256 Phase 3 methadone
28 Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children. Completed NCT00323752 Phase 3
29 Improving Low Bone Mass With Vibration Therapy in Adolescent Idiopathic Scoliosis (AIS) Completed NCT01108211 Phase 3
30 An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion Completed NCT01645111 Phase 2, Phase 3 Clevidipine
31 Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis Recruiting NCT02285621 Phase 3
32 The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery Recruiting NCT03183479 Phase 3 Fibrinogen Concentrate Human;Normal saline
33 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Recruiting NCT02558010 Phase 3 Methadone;Morphine
34 Amantadine Sulphate Usage in Spine Deformities Corrective Surgeries Patients Recruiting NCT03178708 Phase 2, Phase 3 Group A amantadine sulfate
35 Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease Enrolling by invitation NCT02496364 Phase 3 Placebo (Topical);Placebo (Intravenous);Tranexamic Acid (Topical);Tranexamic Acid (Intravenous)
36 Multicenter Schroth Exercise Trial for Scoliosis Unknown status NCT01610908 Phase 2
37 The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery Completed NCT01148888 Phase 2 Magnesium
38 Comparing Two Instrumentation Systems for the Treatment of Adolescent Scoliosis Completed NCT00273598 Phase 2
39 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed NCT01813058 Phase 1, Phase 2 Tranexamic Acid;Placebo
40 Comparison of the Efficacy of Ketamine in Pediatric Patients With Idiopathic Scoliosis After Surgery Completed NCT02571491 Phase 2 Ketamine Hydrochloride;Remifentanil;Morphine hydrochloride
41 Methadone vs Magnesium in Spinal Fusion Completed NCT01795495 Phase 2 Methadone hydrochloride;Magnesium Sulfate;Remifentanil
42 Phase II Clinical Study of Thalidomide in the Treatment of Ankylosing Spondylitis Completed NCT02201043 Phase 2 Thalidomide 150mg;Thalidomide 100mg;Placebo
43 The Use of Dermabond Versus Standard Staple for Wound Closure in Children With Neuromuscular Scoliosis Undergoing Spinal Deformity Correction Surgery Recruiting NCT01135940 Phase 2
44 Value of 3D Modeling in Spine Surgery Recruiting NCT02771899 Phase 2
45 Safety and Efficacy Study of Spinal Tethering Recruiting NCT02897453 Phase 2
46 Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion Recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
47 Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation Recruiting NCT02388165 Phase 2
48 Non-Idiopathic Scoliosis Treated With Tranexamic Acid Suspended NCT01089140 Phase 2 Tranexamic acid 10mg/kg/hr;Tranexamic acid 100 mg/kg/h infusion;Saline solution
49 Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) Syndrome Terminated NCT00527878 Phase 2 Ranitidine;Placebo
50 Safety and Efficacy of Body-mapping Tank Top Equipped With Biofeedback System for Adolescent With Early Scoliosis Completed NCT02471508 Phase 1

Search NIH Clinical Center for Scoliosis

Cochrane evidence based reviews: scoliosis

Genetic Tests for Scoliosis

Genetic tests related to Scoliosis:

id Genetic test Affiliating Genes
1 Scoliosis 29

Anatomical Context for Scoliosis

MalaCards organs/tissues related to Scoliosis:

39
Bone, Testes, Skin, Spinal Cord, Brain, Lung, Skeletal Muscle

Publications for Scoliosis

Articles related to Scoliosis:

(show top 50) (show all 834)
id Title Authors Year
1
Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis. ( 28038693 )
2017
2
Analysing the change of sagittal balance in patients with Lenke 5 idiopathic scoliosis. ( 28889983 )
2017
3
Asymmetry of the Vertebral Body and Pedicles in the True Transverse Plane in Adolescent Idiopathic Scoliosis: A CT-Based Study. ( 28038692 )
2017
4
Pulmonary function and thoracic deformities in adolescent idiopathic scoliosis 27 years or longer after spinal fusion with Harrington instrument. ( 28887065 )
2017
5
Scoliosis in Rett Syndrome: Progression, Comorbidities, and Predictors. ( 28347601 )
2017
6
Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis-a guide to reference values using serial imaging. ( 28065817 )
2017
7
Impact of Scoliosis Severity on Functional Capacity in Patients with Adolescent Idiopathic Scoliosis. ( 28872419 )
2017
8
Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis. ( 28050819 )
2017
9
An immediate effect of PNF specific mobilization on the angle of trunk rotation and the Trunk-Pelvis-Hip Angle range of motion in adolescent girls with double idiopathic scoliosis-a pilot study. ( 28905003 )
2017
10
Full fusion of proximal thoracic curve helps to prevent postoperative cervical tilt in Lenke type 2 adolescent idiopathic scoliosis patients with right-elevated shoulder. ( 28835232 )
2017
11
Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis. ( 28334814 )
2017
12
Distal adding-on phenomenon in adolescent idiopathic scoliosis patients with thoracolumbar vertebra fusion: A case-control study. ( 28930855 )
2017
13
Diffusion Tensor Imaging of Lumbar Vertebras in Female Adolescent Idiopathic Scoliosis: Initial Findings. ( 28937482 )
2017
14
Can surgery for adolescent idiopathic scoliosis of less than 50 degrees of main thoracic curve achieve good results? ( 28943143 )
2017
15
Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee. ( 28259272 )
2017
16
Thumb Ossification Composite Index (TOCI) for Predicting Peripubertal Skeletal Maturity and Peak Height Velocity in Idiopathic Scoliosis: A Validation Study of Premenarchal Girls with Adolescent Idiopathic Scoliosis Followed Longitudinally Until Skeletal Maturity. ( 28872525 )
2017
17
Familial lumbar Scheuermann disease with idiopathic scoliosis in China: First case report. ( 28640085 )
2017
18
Genetic variant of BNC2 gene is functionally associated with adolescent idiopathic scoliosis in Chinese population. ( 28342042 )
2017
19
A novel TRAPPC11 mutation in two Turkish families associated with cerebral atrophy, global retardation, scoliosis, achalasia and alacrima. ( 27707803 )
2017
20
Multimodal intraoperative neuromonitoring in scoliosis surgery: A two-year prospective analysis in a single centre. ( 28084243 )
2017
21
Is a persistent central canal a risk factor for neurological injury in patients undergoing surgical correction of scoliosis? ( 28920082 )
2017
22
Spine Growth Modulation in Early Adolescent Idiopathic Scoliosis: Two-Year Results of Prospective US FDA IDE Pilot Clinical Safety Study of Titanium Clip-Screw Implant. ( 28882349 )
2017
23
Unusual Mechanism for Superior Mesenteric Artery Syndrome after Scoliosis Surgery. ( 28759898 )
2017
24
Magnetically controlled growing rods for scoliosis surgery. ( 28044467 )
2017
25
Early Ambulation Decreases Length of Hospital Stay, Perioperative Complications and Improves Functional Outcomes in Elderly Patients Undergoing Surgery for Correction of Adult Degenerative Scoliosis. ( 28902101 )
2017
26
Radiographic Risk Factors of Reoperation Following Minimally Invasive Decompression for Lumbar Canal Stenosis Associated With Degenerative Scoliosis and Spondylolisthesis. ( 28894678 )
2017
27
Superior Mesenteric Artery Syndrome as a Complication of Scoliosis Surgery. ( 28437498 )
2017
28
Surgical Treatment With Pedicle Screws of Scoliosis Associated With Osteogenesis Imperfecta in Children. ( 28882354 )
2017
29
Is the Superior Articular Process a Reliable Landmark for Determining the Transverse Plane Angulation of Thoracic Pedicles in Patients With Adolescent Idiopathic Scoliosis? ( 28038694 )
2017
30
A Comparative Study of Sagittal Balance in Patients with Neuromuscular Scoliosis. ( 28954007 )
2017
31
Unique local bone tissue characteristics in iliac crest bone biopsy from adolescent idiopathic scoliosis with severe spinal deformity. ( 28054655 )
2017
32
Differential Rod Contouring is Essential for Improving Vertebral Rotation in Patients With Adolescent Idiopathic Scoliosis: Thoracic Curves Assessed With Intraoperative CT. ( 28953709 )
2017
33
Progression of trunk imbalance in adolescent idiopathic scoliosis with a thoracolumbar/lumbar curve: is it predictable at the initial visit? ( 28885088 )
2017
34
The oldest record of aquatic amniote congenital scoliosis. ( 28934336 )
2017
35
Uniplanar Versus Fixed Pedicle Screws in the Correction of Thoracic Kyphosis in the Treatment of Adolescent Idiopathic Scoliosis (AIS). ( 28060179 )
2017
36
Predictors for Postoperative Shoulder Balance in Lenke 1 Adolescent Idiopathic Scoliosis: A Prospective Cohort Study. ( 28038696 )
2017
37
Accelerated Discharge Protocol for Posterior Spinal Fusion Patients With Adolescent Idiopathic Scoliosis Decreases Hospital Postoperative Charges 22. ( 28072636 )
2017
38
Outcomes of Primary Posterior Spinal Fusion for Scoliosis in Spinal Muscular Atrophy: Clinical, Radiographic, and Pulmonary Outcomes and Complications. ( 28777284 )
2017
39
Scapular kinematics in adolescent idiopathic scoliosis: A three-dimensional motion analysis during multiplanar humeral elevation. ( 28823466 )
2017
40
Anterior release may not be necessary for idiopathic scoliosis with large curve of more than 75A^ and flexibility less than 25. ( 28939170 )
2017
41
Six-Month Follow-up of Supervised Spinal Stabilization Exercises for Low Back Pain in Adolescent Idiopathic Scoliosis. ( 27984472 )
2017
42
Whether Orthotic Management and Exercise are Equally Effective to the Patients With Adolescent Idiopathic Scoliosis in Mainland China?: A Randomized Controlled Trial Study. ( 28885287 )
2017
43
The optimal treatment for symptomatic neurogenic claudication or radiculopathy in the presence of mild degenerative scoliosis remains unclear. ( 27986245 )
2017
44
Posture Alignment of Adolescent Idiopathic Scoliosis: Photogrammetry in Scoliosis School Screening. ( 28822476 )
2017
45
Porcine spine finite element model: a complementary tool to experimental scoliosis fusionless instrumentation. ( 28070685 )
2017
46
Perioperative Spending on Spinal Fusion for Scoliosis for Children With Medical Complexity. ( 28899986 )
2017
47
Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population. ( 28838314 )
2017
48
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese. ( 28902104 )
2017
49
H-reflex changes in adolescents with idiopathic scoliosis: a randomized clinical trial. ( 28932008 )
2017
50
Reactive scoliosis: a challenging phenomenon in adolescent patients with hip arthritis. ( 28913399 )
2017

Variations for Scoliosis

ClinVar genetic disease variations for Scoliosis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NSD1 NM_022455.4(NSD1): c.6050G> A (p.Arg2017Gln) single nucleotide variant Pathogenic/Likely pathogenic rs587784177 GRCh37 Chromosome 5, 176710828: 176710828
2 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949
3 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
4 FBN1 NM_000138.4(FBN1): c.6800A> T (p.Asn2267Ile) single nucleotide variant Pathogenic rs1057518812 GRCh38 Chromosome 15, 48430742: 48430742

Expression for Scoliosis

Search GEO for disease gene expression data for Scoliosis.

Pathways for Scoliosis

GO Terms for Scoliosis

Cellular components related to Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 COL1A1 COL1A2 COL2A1 FBN1
2 proteinaceous extracellular matrix GO:0005578 9.55 COL1A1 COL1A2 COL2A1 FBN1 FBN2
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1
4 extracellular matrix GO:0031012 9.35 COL1A1 COL1A2 COL2A1 FBN1 FBN2
5 microfibril GO:0001527 9.26 FBN1 FBN2
6 collagen type I trimer GO:0005584 8.62 COL1A1 COL1A2

Biological processes related to Scoliosis according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.77 CHD7 COL1A1 COL2A1
2 ossification GO:0001503 9.75 COL1A1 COL2A1 EXT2
3 palate development GO:0060021 9.73 BNC2 CHD7 COL2A1
4 camera-type eye development GO:0043010 9.7 CHD7 FBN1 FBN2
5 collagen catabolic process GO:0030574 9.69 COL1A1 COL1A2 COL2A1
6 blood vessel development GO:0001568 9.61 CHD7 COL1A1 COL1A2
7 limb morphogenesis GO:0035108 9.58 COL2A1 FBN2
8 heart morphogenesis GO:0003007 9.58 CHD7 COL2A1 MESP2
9 protein heterotrimerization GO:0070208 9.57 COL1A1 COL1A2
10 embryonic eye morphogenesis GO:0048048 9.55 FBN1 FBN2
11 skin morphogenesis GO:0043589 9.54 COL1A1 COL1A2
12 collagen fibril organization GO:0030199 9.54 COL1A1 COL1A2 COL2A1
13 bone trabecula formation GO:0060346 9.49 COL1A1 FBN2
14 endochondral bone growth GO:0003416 9.48 BNC2 FGFR3
15 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.46 COL1A1 COL2A1
16 extracellular matrix organization GO:0030198 9.35 COL1A1 COL1A2 COL2A1 FBN1 FBN2
17 endochondral ossification GO:0001958 9.33 COL1A1 COL2A1 FGFR3
18 regulation of cellular response to growth factor stimulus GO:0090287 9.32 FBN1 FBN2
19 sequestering of TGFbeta in extracellular matrix GO:0035583 9.26 FBN1 FBN2
20 skeletal system development GO:0001501 9.17 CHD7 COL1A1 COL1A2 COL2A1 DLL3 FBN1

Molecular functions related to Scoliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 9.16 FBN1 FBN2
2 platelet-derived growth factor binding GO:0048407 9.13 COL1A1 COL1A2 COL2A1
3 extracellular matrix structural constituent GO:0005201 9.02 COL1A1 COL1A2 COL2A1 FBN1 FBN2
4 Notch binding GO:0005112 8.96 DLL3

Sources for Scoliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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