Aliases & Classifications for Scotoma

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Aliases & Descriptions for Scotoma:

Name: Scotoma 10 12
Generalized Visual Field Contraction or Constriction 10
Sector or Arcuate Visual Field Defects 10
Enlarged Paracaecal Scotoma 10
 
Scotoma of Blind Spot Area 10
Blind Spot Area Scotoma 10
Enlarged Angioscotoma 10
Enlarged Blind Spot 10

Classifications:



External Ids:

Disease Ontology10 DOID:9335
SNOMED-CT59 193673000, 33970004
UMLS65 C0029657, C0152192, C0155011 C0155012, more

Summaries for Scotoma

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Wikipedia:68 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards based summary: Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and leukemia. An important gene associated with Scotoma is OPA1 (OPA1, Mitochondrial Dynamin Like GTPase), and among its related pathways is the visual cycle I (vertebrates). Affiliated tissues include eye, liver and breast, and related mouse phenotype cardiovascular system.

Related Diseases for Scotoma

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Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Symptoms for Scotoma

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Drugs & Therapeutics for Scotoma

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Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bevacizumabapproved, investigationalPhase 31875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
RanibizumabapprovedPhase 3, Phase 1, Phase 2460347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
3Angiogenesis InhibitorsPhase 3, Phase 1, Phase 23688
4Immunologic FactorsPhase 3, Phase 1, Phase 218483
5Angiogenesis Modulating AgentsPhase 3, Phase 1, Phase 23611
6Omega 3 Fatty AcidNutraceuticalPhase 3912
7
ImidaclopridPhase 2139105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
8Protective AgentsPhase 25651
9idebenonePhase 219
10AntioxidantsPhase 22442
11
Latanoprostapproved, investigational184130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
12
Luteinapproved, nutraceutical69127-40-25368396, 6433159
Synonyms:
(3R,3'R)-beta,beta-Carotene-3,3'-Diol, Lutein
(3R,3'R,6'R)-Lutein
(3R,3'R,6S)-4,5-Didehydro-5,6-Dihydro-beta,beta-Carotene-3,3'-Diol
3,3'-Dihydroxy-alpha-carotene
4,5-Didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol
All-trans-(+)-Xanthophyll
All-trans-Lutein
All-trans-Xanthophyll
 
Bo-Xan
Lutein
Lutein ester
Luteine
Phylloxanthin
SID548587
Vegetable lutein
Vegetable luteol
beta,epsilon-Carotene-3,3'-diol
trans-Lutein
13Diminazene aceturate10
14Liver Extracts3572
15Tissue Plasminogen Activator202
16Plasminogen198
17Fibrinolytic Agents1567

Interventional clinical trials:

(show all 27)
idNameStatusNCT IDPhase
1Bevacizumab Versus Ranibizumab for Diabetic RetinopathyCompletedNCT00545870Phase 3
2A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular AdhesionCompletedNCT01889251Phase 3
3Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis TherapyRecruitingNCT01255774Phase 3
4Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic LesionsActive, not recruitingNCT01418820Phase 2, Phase 3
5Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD).TerminatedNCT00987129Phase 3
6Scotoma Reduction in AMD Patients Treated With RanibizumabCompletedNCT00467935Phase 1, Phase 2
7Evaluation of Eye Movement Tracking Systems for Visual RehabilitationCompletedNCT00013429Phase 2
8Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial)CompletedNCT00504400Phase 2
9Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic NeuropathyCompletedNCT00747487Phase 2
10Low Vision Study Comparing EV Training vs. CCTV for AMD RehabilitationCompletedNCT00971464Phase 2
11Visuomotor Rehabilitation TrainingCompletedNCT01691027Phase 0
12A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus PhotographCompletedNCT01843582
13The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration TherapyCompletedNCT00921427Phase 0
14Detection of Topographic Residual Acuity in Patients With Age Related Macular DegenerationCompletedNCT00329277
15Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole SurgeryCompletedNCT00419185
16Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular DegenerationCompletedNCT00879671
17Age-related Normative Values for the Octopus 900 PerimeterCompletedNCT01518686
18Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular OedemaRecruitingNCT02457884
19Sparing of the Fovea in Geographic Atrophy ProgressionRecruitingNCT02332343
20Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the RetinaRecruitingNCT02088151
21Treatment Trial for Acute Central Serous ChorioretinopathyRecruitingNCT02784665
22Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial FibrillationRecruitingNCT02424110
23Oxidative Stress and Endothelial Function in Pregnancy ComplicationsRecruitingNCT02603913
24Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma PatientsActive, not recruitingNCT00902109
25Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX PerimeterActive, not recruitingNCT01068938
26Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular DegenerationNot yet recruitingNCT02747368
27Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration ComplicationsNot yet recruitingNCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

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Anatomical Context for Scotoma

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MalaCards organs/tissues related to Scotoma:

33
Eye, Liver, Breast, Retina, Endothelial, T cells, Prostate

Animal Models for Scotoma or affiliated genes

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MGI Mouse Phenotypes related to Scotoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3ABCA4, KCNMA1, OPA1, SLC22A3, SNCA

Publications for Scotoma

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Articles related to Scotoma:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
An adolescent case of familial hyperparathyroidism with a germline frameshift mutation of the CDC73 gene. (26568659)
2015
2
Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study. (26506437)
2015
3
Comprehensive clinical evaluation of a large Spanish family with Anderson-Fabry disease, novel GLA mutation and severe cardiac phenotype. (24679964)
2014
4
Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels. (25046809)
2014
5
Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. (23266269)
2013
6
High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes. (24130685)
2013
7
Effect of diazepam on severity of acute pancreatitis: possible involvement of peripheral benzodiazepine receptors. (23956866)
2013
8
Hirsutella sinensis mycelium suppresses interleukin-1I^ and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. (23459183)
2013
9
Neuropsychiatric symptoms in primary progressive aphasia: phenomenology, pathophysiology, and approach to assessment and treatment. (23997827)
2013
10
A novel PS1 gene mutation in a large Aboriginal kindred. (20481270)
2010
11
Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method. (20472432)
2010
12
Activation of glycolysis and apoptosis in glycogen storage disease type Ia. (19419892)
2009
13
Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma. (18415053)
2008
14
A case study of a graphical misrepresentation: drawing the wrong conclusions about the measles, mumps and rubella virus vaccine. (17867721)
2007
15
Dubin-Johnson syndrome--a clinicopathologic study of twenty cases. (17183837)
2006
16
Regulation of protein synthesis in lymphoblasts from vanishing white matter patients. (16185887)
2006
17
Apolipoprotein E4 genotype increases the risk of postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft surgery. (16953165)
2006
18
Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice. (16880618)
2006
19
Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency. (15928241)
2005
20
Disorders of calcium metabolism during pregnancy and breast feeding]. (16018145)
2005
21
Phosphodiesterase 5 inhibition in chronic heart failure and pulmonary hypertension. (16387567)
2005
22
Metabolic emergencies related to diabetes mellitus: ketoacidosis and hyperosmolar state]. (16035313)
2005
23
Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit Skp2 in early esophageal squamous cell carcinoma. (15161026)
2004
24
Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. (12615701)
2003
25
Pineal germinoma followed by hematogenous metastases. (12602751)
2003
26
Trichophyton raubitschekii: a new agent of dermatophytosis in Brazil? (12639464)
2003
27
Pediatric surgical images: mixed gonadal dysgenesis. (12778409)
2003
28
Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. (12186860)
2002
29
Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitro. (10603396)
2000
30
Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides. (10736423)
2000
31
Urinary fibronectin levels in patients treated with intravesical bacillus Calmette-GuAcrin for superficial bladder cancer. (10895085)
2000
32
Near-normal urinary albumin concentrations predict progression to diabetic nephropathy in Type 1 diabetes mellitus. (11131103)
2000
33
Inhibition of L-type calcium channels by octreotide in isolated human neuroendocrine tumor cells of the gut. (9753663)
1998
34
Aromatase cytochrome P450 transcripts are detected in fractured human bone but not in normal skeletal tissue. (9356737)
1997
35
Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression. (9169593)
1997
36
Simultaneous multiple brain hemorrhage associated with migraine--a case report. (9194542)
1997
37
In vitro cytogenetic analysis of the effects of oxytocin on human peripheral blood lymphocytes. (8841495)
1996
38
Induction of ceramide glucosyltransferase activity in cultured human keratinocytes. Correlation with culture differentiation. (8703011)
1996
39
H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. (8491191)
1993
40
Fleroxacin in the treatment of chancroid: an open study in men seropositive or seronegative for the human immunodeficiency virus type 1. (8452188)
1993
41
Iodine induced splitting of peptide bonds in human thyroglobulin. (7522534)
1993
42
Cannabinoid-receptor expression in human leukocytes. (8508790)
1993
43
Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. (1549469)
1992
44
Some properties of gingival 12-lipoxygenase activity in human and dog. (2124101)
1990
45
Human chorionic gonadotrophin producing ovarian dysgerminoma. (3665890)
1987
46
Treatment of dumping syndrome by interposition of an antiperistaltic segment of small intestine. (1123267)
1975
47
Chondrosarcoma of the hand arising from a pre-existent benign solitary enchondroma. (1192657)
1975
48
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
49
An electromyographic study of lagophthalmos in leprosy. (5749655)
1968
50
Hypervitaminosis D; report of nine cases. (18909525)
1948

Variations for Scotoma

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Expression for genes affiliated with Scotoma

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Search GEO for disease gene expression data for Scotoma.

Pathways for genes affiliated with Scotoma

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Pathways related to Scotoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2ABCA4, RDH5

GO Terms for genes affiliated with Scotoma

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Sources for Scotoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet