MCID: SCT002
MIFTS: 41

Scotoma malady

Eye category

Summaries for Scotoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards: Scotoma, also known as generalized visual field contraction, is related to blindness and constrictive pericarditis. An important gene associated with Scotoma is PRPH (peripherin). The compound gtp have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and retina, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Scotoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

scotoma 8 10 61
generalized visual field contraction 8
arcuate visual field defects 8
blind spot area scotoma nos 8
enlarged paracaecal scotoma 8
scotoma of blind spot area 8
enlarged angioscotoma 8
enlarged blind spot 8
constriction 8
sector 8


External Ids:

Disease Ontology8 DOID:9335
SNOMED-CT57 193673000, 33970004
ICD9CM27 368.44

Related Diseases for Scotoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Clinical Features for Scotoma

Drugs & Therapeutics for Scotoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Scotoma

Search CenterWatch for Scotoma

Genetic Tests for Scotoma

Anatomical Context for Scotoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Scotoma:

33
Brain, Cortex, Retina, Prefrontal cortex, Temporal lobe, Occipital lobe, Pituitary

Animal Models for Scotoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Scotoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8ABCA4, PRPF3, GUCY2D, OPA3, UNC119
2MP:00036317.5TECTA, KCNMA1, OPA3, GUCY2D, PRL, PRPH

Publications for Scotoma

Sources:
51PubMed
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Articles related to Scotoma:

(show top 50)    (show all 195)
idTitleAuthorsYear
1
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. (24045572)
2014
2
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. (23697959)
2013
3
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. (23620092)
2013
4
Rehabilitative approach in patients with ring scotoma. (24093190)
2013
5
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates. (24357841)
2013
6
The effect of strabismus on object detection in the ring scotoma of a monocular bioptic telescope. (23639041)
2013
7
A behavioral task for the validation of a gaze-contingent simulated scotoma. (23526257)
2013
8
Opposite effects of perceptual and working memory load on perceptual filling-in of an artificial scotoma. (24168648)
2012
9
Cecocentral scotoma as the initial manifestation of subacute bacterial endocarditis. (21468335)
2011
10
Size scaling compensates for sensitivity loss produced by a simulated central scotoma in a shape-from-texture task. (21047750)
2010
11
Neural correlates of perceptual filling-in of an artificial scotoma in humans. (17360383)
2007
12
Resolution of macular scotoma after radial optic neurotomy in central retinal vein occlusion. (16468557)
2006
13
A novel high-resolution kinetic method for visual field mapping of scotoma in age-related macular degeneration. (15497550)
2004
14
Artificial scotoma-induced perceptual distortions are orientation dependent and short lived. (15137584)
2004
15
Development of a viewing strategy during adaptation to an artificial central scotoma. (15358064)
2004
16
Partial recovery of the visual field scotoma upon early retinal photocoagulation and the medical therapy in a preeclamptic patient. (15646176)
2004
17
Association of preoperative photoreceptor displacement and improved central scotoma after idiopathic macular hole surgery. (12414433)
2002
18
Junctional scotoma in giant cerebral aneurysm. (12546452)
2002
19
Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. (11730655)
2001
20
Compression of the prechiasmatic optic nerve produces a junctional scotoma. (10458197)
1999
21
Chronic vitamin E deficiency causing spinocerebellar degeneration, peripheral neuropathy, and centro-cecal scotomata. (10198917)
1999
22
Location and stability of a newly established eccentric retinal locus suitable for reading, achieved through training of patients with a dense central scotoma. (9875992)
1998
23
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
24
Evaluation of amblyopic scotoma by electrophysiological examinations and computerized perimetry. (8823598)
1996
25
Responses of cells in monkey visual cortex during perceptual filling-in of an artificial scotoma. (7477262)
1995
26
A cluster and scotoma analysis based on empiric criteria. (8299977)
1993
27
Effect of a scotoma on eye movements during visual search. (2622676)
1989
28
Post-traumatic headache with scintillating scotoma treated with phenytoin (Dilantin). (2507477)
1989
29
Scintillating scotoma after retinal detachment surgery. (3337202)
1988
30
Residual vision in a scotoma. A follow-up study of 'form' discrimination. (3801855)
1987
31
Acute, severe, symmetric visual loss with cecocentral scotomas due to olfactory groove meningioma. (2947926)
1986
32
Reading with a macular scotoma. I. Retinal location of scotoma and fixation area. (3721792)
1986
33
Junction scotoma and involvement of the optochiasmal junction. (4010084)
1985
34
Visual field recovery from scotoma in patients with postgeniculate damage. A review of 55 cases. (4005527)
1985
35
Scintillating scotoma as the first symptom of systemic lupus erythematosus. (4003508)
1985
36
Anomalous macular vessel and associated acquired paracentral scotoma. (6660272)
1983
37
Monocular performance of functional amblyopes: another look at the scotoma hypothesis. (677258)
1978
38
Sixth annual Richard G. Scobee Memorial Lecture. Some clinical implications of strabismic suppression scotoma. (970710)
1976
39
Duration of the scintillating scotoma. (1123308)
1975
40
The hemodynamics of preheadache scotoma in migraine. (4811861)
1974
41
Scotoma due to arterial hypotension. (4800601)
1973
42
Binocular suppression scotoma: its role in phorias and intermittent tropias. (5425262)
1970
43
Visual phenomena associated with central scotoma caused by obstruction of the central retinal vein. (5905199)
1966
44
An unusual central scotoma. (13985825)
1962
45
The roving ring scotoma with its jack-in-the-box phenomenon of strong-plus (aphakic) spectacle lenses. (13784293)
1961
46
Peripheral melanoblastoma of choroid; (para) central scotoma as an initial sign. (14410612)
1960
47
The temporal half-moon: a self-observation in flimmer scotoma. (13217784)
1954
48
A central scotoma occurring during systemic cortisone therapy. (13116658)
1954
49
Ring Scotoma after Retrobulbar Neuritis. (19993471)
1947
50
Clinical Contributions to the Study of Ring-Scotoma. (16691794)
1887

Genetic Variations for Scotoma

Expression for genes affiliated with Scotoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for genes affiliated with Scotoma

Compounds for genes affiliated with Scotoma

Sources:
45Novoseek, 29IUPHAR
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Compounds related to Scotoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gtp45 299.7ABCA4, VARS, GUCY2D, KCNMA1

GO Terms for genes affiliated with Scotoma

Sources:
16Gene Ontology
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Cellular components related to Scotoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.8ABCA4, GUCY2D

Biological processes related to Scotoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:0076019.2ABCA4, GUCY2D, OPA3, UNC119

Products for genes affiliated with Scotoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Scotoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet