Aliases & Classifications for Scotoma

MalaCards integrated aliases for Scotoma:

Name: Scotoma 12 72 28 14
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
SNOMED-CT 64 193673000 33970004

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and cone-rod dystrophy 2. An important gene associated with Scotoma is TMEM126A (Transmembrane Protein 126A), and among its related pathways/superpathways is the visual cycle I (vertebrates). The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related phenotype is nervous system.

Wikipedia : 72 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 optic atrophy 1 11.0
2 cone-rod dystrophy 2 10.8
3 migraine, familial hemiplegic, 1 10.8
4 mohr-tranebjaerg syndrome 10.8
5 migraine, familial hemiplegic, 2 10.8
6 birdshot chorioretinopathy 10.8
7 migraine, familial hemiplegic, 3 10.8
8 optic atrophy 5 10.8
9 optic atrophy 7 with or without auditory neuropathy 10.8
10 familial hemiplegic migraine 10.8
11 retinitis 10.3
12 macular degeneration, age-related, 1 10.2
13 migraine with or without aura 1 10.2
14 retinitis pigmentosa 19 10.1 ABCA4 KCNMA1
15 aging 10.1
16 tritanopia 10.0 MT-ND4 SNCA
17 neuritis 10.0
18 chromosome 3q29 deletion syndrome 9.9 DLG3 SNCA
19 3-methylglutaconic aciduria, type v 9.9 MT-ND4 SNCA
20 macular holes 9.9
21 headache 9.9
22 optic nerve disease 9.8 MT-ND4 OPA1
23 systemic lupus erythematosus 9.8
24 strabismus 9.8
25 stargardt disease 9.8
26 cataract 9.8
27 amblyopia 9.8
28 open-angle glaucoma 9.8
29 choroiditis 9.8
30 uveitis 9.8
31 cerebritis 9.8
32 adenoma 9.8
33 lupus erythematosus 9.8
34 anterior uveitis 9.8
35 aneurysm 9.8
36 pituitary tumors 9.8
37 blood group, i system 9.7
38 retinal detachment 9.7
39 stroke, ischemic 9.7
40 astigmatism 9.7
41 meningioma, familial 9.7
42 hepatitis c virus 9.7
43 episodic pain syndrome, familial, 1 9.7
44 hepatitis 9.7
45 retinal vein occlusion 9.7
46 sinusitis 9.7
47 cytomegalovirus retinitis 9.7
48 migraine with aura 9.7
49 neuroretinitis 9.7
50 endocarditis 9.7

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

MGI Mouse Phenotypes related to Scotoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 ABCA4 ARSG DLG3 KCNMA1 OPA1 SNCA

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 3,Phase 1,Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3
3 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2
4 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2
5 Omega 3 Fatty Acid Nutraceutical Phase 3
6
Idebenone Approved, Investigational Phase 2 58186-27-9
7
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
8 Ubiquinone Phase 2
9 Micronutrients Phase 2
10 Trace Elements Phase 2
11 Protective Agents Phase 2
12 Antioxidants Phase 2
13
Latanoprost Approved, Investigational 130209-82-4 5311221 5282380
14
Lutein Approved, Investigational, Nutraceutical 127-40-2 6433159
15 Diminazene aceturate
16 Anti-Infective Agents
17 Antiprotozoal Agents
18 Antiparasitic Agents
19 Fibrinolytic Agents
20 Tissue Plasminogen Activator
21 Plasminogen
22 Liver Extracts

Interventional clinical trials:

(show all 35)

# Name Status NCT ID Phase Drugs
1 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Unknown status NCT01255774 Phase 3 ranibizumab
2 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Unknown status NCT01418820 Phase 2, Phase 3
3 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3 bevacizumab;Ranibizumab
4 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3 Ocriplasmin;Sham injection
5 Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD). Terminated NCT00987129 Phase 3
6 Scotoma Reduction in AMD Patients Treated With Ranibizumab Completed NCT00467935 Phase 1, Phase 2 intravitreal injection Lucentis (ranibizumab)
7 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
8 Low Vision Study Comparing EV Training vs. CCTV for AMD Rehabilitation Completed NCT00971464 Phase 2
9 Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial) Completed NCT00504400 Phase 2 Intravitreal injection ranibizumab
10 Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy Completed NCT00747487 Phase 2 Idebenone;Placebo
11 Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients Unknown status NCT00902109
12 Visuomotor Rehabilitation Training for Manual Task Deficits From Macular Scotomas Completed NCT01691027
13 A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph Completed NCT01843582
14 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
15 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
16 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277
17 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671
18 A Clinical Study of Fundus Findings in Toxaemia of Pregnancy Completed NCT03076619
19 Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery Completed NCT00419185
20 Age-related Normative Values for the Octopus 900 Perimeter Completed NCT01518686
21 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
22 Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV) Recruiting NCT02829606
23 Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery Recruiting NCT02894424
24 Telescope Exchange Study Recruiting NCT03011554
25 Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina Recruiting NCT02088151
26 Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial Fibrillation Recruiting NCT02424110
27 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
28 Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration Complications Recruiting NCT02557451
29 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema Active, not recruiting NCT02457884
30 Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter Active, not recruiting NCT01068938
31 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730
32 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504
33 Treatment Trial for Acute Central Serous Chorioretinopathy Enrolling by invitation NCT02784665
34 Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration Enrolling by invitation NCT02747368
35 " Sweeper " and Epiretinal Membrane Surgery Not yet recruiting NCT03350607

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

Genetic tests related to Scotoma:

# Genetic test Affiliating Genes
1 Scotoma 28

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

38
Eye, Testes, Retina, Endothelial, Liver, Cortex, Pituitary

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 227)
# Title Authors Year
1
Simulation of a central scotoma using contact lenses with an opaque centre. ( 29265475 )
2018
2
TEMPORAL THINNING IN SICKLE CELL RETINOPATHY IS ASSOCIATED WITH DIMINISHED PERFUSION ON OCTA AND DENSE SCOTOMA ON MICROPERIMETERY. ( 28644178 )
2017
3
Acquired unilateral scotoma. ( 28684101 )
2017
4
Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma. ( 28821922 )
2017
5
Retinal slippage fold causing a matching contralateral scotoma. ( 28395868 )
2017
6
Temporal crescent syndrome vs arcuate scotoma. ( 28318737 )
2017
7
Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation. ( 28282064 )
2017
8
Artificial scotoma estimation based on population receptive field mapping. ( 29253656 )
2017
9
Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma. ( 28614218 )
2017
10
Ocular and Systemic Risk Factors of Different Morphologies of Scotoma in Patients with Normal-Tension Glaucoma. ( 28815087 )
2017
11
Retinal Nerve Fiber Layer Defect and Paracentral Scotoma after Internal Limiting Membrane Peeling with a Nitinol Loop. ( 29276228 )
2017
12
SCOTOMA CHARACTERISTICS IN MACULAR TELANGIECTASIA TYPE 2: MacTel Project Report No. 7-The MacTel Research Group. ( 28609329 )
2017
13
Comparison of retinal vessel diameter between open-angle glaucoma patients with initial parafoveal scotoma and peripheral nasal step. ( 27916714 )
2016
14
The Effects of Nocturnal Dip and Blood Pressure Variability on Paracentral Scotoma in Early Open-Angle Glaucoma. ( 27128963 )
2016
15
Assessing the GOANNA Visual Field Algorithm Using Artificial Scotoma Generation on Human Observers. ( 27622080 )
2016
16
Characteristics of the preferred retinal loci of better and worse seeing eyes of patients with a central scotoma. ( 27769327 )
2016
17
MAPPING THE DENSE SCOTOMA AND ITS ENLARGEMENT IN STARGARDT DISEASE. ( 26909568 )
2016
18
Optic Disk Pit with Sudden Central Visual Field Scotoma. ( 27872777 )
2016
19
Structure-Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma. ( 26848881 )
2016
20
Progressing Scintillating Scotoma Captured on Automated Visual Field Testing. ( 26854039 )
2016
21
Scotoma Visibility and Reading Rate with Bilateral Central Scotomas. ( 28030516 )
2016
22
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. ( 26060390 )
2015
23
Optimal point of fixation to faces for vision with a simulated central scotoma. ( 26326621 )
2015
24
Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. ( 26476213 )
2015
25
Long-lasting, dense scotoma under light-adapted conditions in patient with multiple evanescent white dot syndrome. ( 26678272 )
2015
26
Random word recognition chart helps scotoma assessment in low vision. ( 25946100 )
2015
27
Stop before you saccade: Looking into an artificial peripheral scotoma. ( 26067525 )
2015
28
Scotoma analysis of 10-2 visual field testing with a red target in screening for hydroxychloroquine retinopathy. ( 26316692 )
2015
29
Microperimetry biofeedback training in a patient with bilateral myopic macular degeneration with central scotoma. ( 26265646 )
2015
30
Size of the foveal blue scotoma related to the shape of the foveal pit but not to macular pigment. ( 25449158 )
2015
31
Comparison of Risk Factors for Initial Central Scotoma versus Initial Peripheral Scotoma in Normal-tension Glaucoma. ( 25829826 )
2015
32
fMRI of the rod scotoma elucidates cortical rod pathways and implications for lesion measurements. ( 25848028 )
2015
33
Central scotoma and 'muddled thinking' as migraine aura. ( 24045570 )
2014
34
Reading with peripheral vision: a comparison of reading dynamic scrolling and static text with a simulated central scotoma. ( 24680772 )
2014
35
Adaptation to a simulated central scotoma during visual search training. ( 24456805 )
2014
36
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. ( 25313789 )
2014
37
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. ( 24045572 )
2014
38
Paracentral scotoma in glaucoma detected by 10-2 but not by 24-2 perimetry. ( 24442888 )
2014
39
Xanthic scotoma. ( 25256032 )
2014
40
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. ( 24595065 )
2014
41
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma: Reply. ( 25313790 )
2014
42
Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma. ( 23972895 )
2013
43
Arcuate scotoma associated with traction at the optic disc. ( 23449516 )
2013
44
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates. ( 24357841 )
2013
45
A behavioral task for the validation of a gaze-contingent simulated scotoma. ( 23526257 )
2013
46
Scotomas in molecular virology and epidemiology of hepatitis C virus. ( 24307785 )
2013
47
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. ( 23697959 )
2013
48
Fixation stability and scotoma mapping for patients with low vision. ( 23334309 )
2013
49
Rehabilitative approach in patients with ring scotoma. ( 24093190 )
2013
50
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. ( 23481153 )
2013

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

Pathways related to Scotoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.36 ABCA4 RDH5

GO Terms for Scotoma

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I GO:0005747 8.62 MT-ND4 SNCA

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.56 ABCA4 DLG3 KCNMA1 TRPM1
2 response to stimulus GO:0050896 9.46 ABCA4 OPA1 RDH5 TRPM1
3 retinoid metabolic process GO:0001523 9.32 ABCA4 RDH5
4 aging GO:0007568 9.13 MT-ND4 OPA1 SNCA
5 visual perception GO:0007601 8.92 ABCA4 OPA1 RDH5 TRPM1

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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