MCID: SCT002
MIFTS: 42

Scotoma malady

Eye diseases category

Summaries for Scotoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards: Scotoma, also known as generalized visual field contraction, is related to impotence and retinal degeneration. An important gene associated with Scotoma is PRPH (peripherin). The compound gtp have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and pituitary, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Scotoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

scotoma 8 10 60
generalized visual field contraction 8
arcuate visual field defects 8
blind spot area scotoma nos 8
enlarged paracaecal scotoma 8
scotoma of blind spot area 8
enlarged angioscotoma 8
enlarged blind spot 8
constriction 8
sector 8


External Ids:

Disease Ontology8 DOID:9335
SNOMED-CT56 193673000, 33970004
ICD9CM27 368.44

Related Diseases for Scotoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Clinical Features for Scotoma

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Drugs & Therapeutics for Scotoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Scotoma

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Anatomical Context for Scotoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Scotoma:

32
Eye, Testes, Pituitary, Cortex, Brain, Retina, Occipital lobe

Animal Models for Scotoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Scotoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8ABCA4, PRPF3, GUCY2D, OPA3, UNC119
2MP:00036317.5TECTA, KCNMA1, OPA3, GUCY2D, PRL, PRPH

Publications for Scotoma

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50PubMed
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Articles related to Scotoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. (24045572)
2014
2
Central scotoma and 'muddled thinking' as migraine aura. (24045570)
2014
3
Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma. (23972895)
2013
4
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates. (24357841)
2013
5
A behavioral task for the validation of a gaze-contingent simulated scotoma. (23526257)
2013
6
Patient awareness of binocular central scotoma in age-related macular degeneration. (22863789)
2012
7
FUNDUS AUTOFLUORESCENCE IMAGING IN A PATIENT WITH RAPIDLY DEVELOPING SCOTOMA. (23293707)
2012
8
Object detection in the ring scotoma of a monocular bioptic telescope. (21555615)
2011
9
Cecocentral scotoma as the initial manifestation of subacute bacterial endocarditis. (21468335)
2011
10
Size scaling compensates for sensitivity loss produced by a simulated central scotoma in a shape-from-texture task. (21047750)
2010
11
Retinal imaging with adaptive optics scanning laser ophthalmoscopy in unexplained central ring scotoma. (18413527)
2008
12
Neural correlates of perceptual filling-in of an artificial scotoma in humans. (17360383)
2007
13
Resolution of macular scotoma after radial optic neurotomy in central retinal vein occlusion. (16468557)
2006
14
Central scotoma associated with intraocular silicone oil tamponade develops before oil removal. (16047183)
2006
15
Artificial scotoma-induced perceptual distortions are orientation dependent and short lived. (15137584)
2004
16
Association of preoperative photoreceptor displacement and improved central scotoma after idiopathic macular hole surgery. (12414433)
2002
17
Junctional scotoma in giant cerebral aneurysm. (12546452)
2002
18
The effects of simulated cataract on reading with normal vision and simulated central scotoma. (10755163)
1999
19
Location and stability of a newly established eccentric retinal locus suitable for reading, achieved through training of patients with a dense central scotoma. (9875992)
1998
20
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
21
Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. (8841306)
1996
22
Evaluation of amblyopic scotoma by electrophysiological examinations and computerized perimetry. (8823598)
1996
23
Effects of a laser-induced temporary scotoma on target acquisition performance. (7642184)
1995
24
Visual scotoma and visual afterimages: some evidence that the perceived visual afterimage may not be a purely retinal phenomenon: a single case study. (8668442)
1995
25
A cluster and scotoma analysis based on empiric criteria. (8299977)
1993
26
The effect of a foveal scotoma on the visual lobe. (3211561)
1988
27
Eccentric fixation with macular scotoma. (3338884)
1988
28
A study of the value of the central and peripheral isoptres in assessing visual field progression in the presence of paracentral scotoma measurements. (3620421)
1987
29
Clinical spatial contrast sensitivity measurement: implications of artificial scotoma experiments. (3953753)
1986
30
Acute, severe, symmetric visual loss with cecocentral scotomas due to olfactory groove meningioma. (2947926)
1986
31
Reading with a macular scotoma. I. Retinal location of scotoma and fixation area. (3721792)
1986
32
Junction scotoma and involvement of the optochiasmal junction. (4010084)
1985
33
Visual field recovery from scotoma in patients with postgeniculate damage. A review of 55 cases. (4005527)
1985
34
Anomalous macular vessel and associated acquired paracentral scotoma. (6660272)
1983
35
Central versus peripheral vision: evaluation of the residual function resulting from a uniocular macular scotoma. (742652)
1978
36
Monocular performance of functional amblyopes: another look at the scotoma hypothesis. (677258)
1978
37
Sixth annual Richard G. Scobee Memorial Lecture. Some clinical implications of strabismic suppression scotoma. (970710)
1976
38
Duration of the scintillating scotoma. (1123308)
1975
39
The hemodynamics of preheadache scotoma in migraine. (4811861)
1974
40
Scotoma due to arterial hypotension. (4800601)
1973
41
Binocular suppression scotoma: its role in phorias and intermittent tropias. (5425262)
1970
42
Visual phenomena associated with central scotoma caused by obstruction of the central retinal vein. (5905199)
1966
43
UNILATERAL SCOTOMA AS THE PRESENTING SIGN OF PITUITARY TUMOR. (14265603)
1965
44
THE BJERRUM SCOTOMA. (14269898)
1964
45
An unusual central scotoma. (13985825)
1962
46
The roving ring scotoma with its jack-in-the-box phenomenon of strong-plus (aphakic) spectacle lenses. (13784293)
1961
47
Peripheral melanoblastoma of choroid; (para) central scotoma as an initial sign. (14410612)
1960
48
The temporal half-moon: a self-observation in flimmer scotoma. (13217784)
1954
49
A central scotoma occurring during systemic cortisone therapy. (13116658)
1954
50
Scotoma as a complication of decompression sickness. (20997673)
1946

Genetic Variations for Scotoma

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Expression for genes affiliated with Scotoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scotoma

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Pathways for genes affiliated with Scotoma

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Compounds for genes affiliated with Scotoma

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44Novoseek, 28IUPHAR
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Compounds related to Scotoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gtp44 289.7ABCA4, VARS, GUCY2D, KCNMA1

GO Terms for genes affiliated with Scotoma

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16Gene Ontology
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Cellular components related to Scotoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.8ABCA4, GUCY2D

Biological processes related to Scotoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:0076019.2ABCA4, GUCY2D, OPA3, UNC119

Products for genes affiliated with Scotoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Scotoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet