Aliases & Classifications for Scotoma

About this section

Aliases & Descriptions for Scotoma:

Name: Scotoma 11 26 13
Generalized Visual Field Contraction or Constriction 11
Sector or Arcuate Visual Field Defects 11
Enlarged Paracaecal Scotoma 11
 
Scotoma of Blind Spot Area 11
Blind Spot Area Scotoma 11
Enlarged Angioscotoma 11
Enlarged Blind Spot 11

Classifications:



External Ids:

Disease Ontology11 DOID:9335
SNOMED-CT61 193673000, 33970004

Summaries for Scotoma

About this section
Wikipedia:70 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards based summary: Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and migraine, familial hemiplegic, 2. An important gene associated with Scotoma is TMEM126A (Transmembrane Protein 126A), and among its related pathways are Metabolism of fat-soluble vitamins and the visual cycle I (vertebrates). Affiliated tissues include eye, testes and retina.

Related Diseases for Scotoma

About this section

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1optic atrophy 110.9
2migraine, familial hemiplegic, 210.7
3migraine, familial hemiplegic, 310.7
4optic atrophy 710.7
5migraine, familial hemiplegic, 110.7
6leber optic atrophy10.7
7retinitis10.2
8noninfectious dermatoses of eyelid10.2MT-ND4, TMEM126A
9dandy-walker malformation with nasopharyngeal teratoma and diaphragmatic hernia10.1OPA1, TMEM126A
10leukodystrophy, hypomyelinating, 510.1CYP4V2, KCNMA1
11hyperinsulinism10.1ABCA4, KCNMA1
12patau syndrome10.0MT-ND4, SNCA
13hypertrichosis terminalis, generalized, with or without gingival hyperplasia10.0ABCA4, RDH5
14neuritis9.9
15chronic intestinal vascular insufficiency9.8MT-ND4, SNCA
16mitochondrial neurogastrointestinal encephalopathy disease9.8MT-ND4, OPA1
17macular holes9.8
18headache9.8
19impetigo herpetiformis9.8ABCA4, RDH5
20systemic lupus erythematosus9.7
21stargardt disease9.7
22cataract9.7
23amblyopia9.7
24open-angle glaucoma9.7
25choroiditis9.7
26uveitis9.7
27cerebritis9.7
28strabismus9.7
29adenoma9.7
30lupus erythematosus9.7
31anterior uveitis9.7
32aneurysm9.7
33pituitary tumors9.7
34hepatitis c virus9.6
35hepatitis9.6
36retinal vein occlusion9.6
37sinusitis9.6
38cytomegalovirus retinitis9.6
39migraine with aura9.6
40neuroretinitis9.6
41endocarditis9.6
42astigmatism9.6
43myopia9.6
44optic neuritis9.6
45hepatitis c9.6
46central retinal vein occlusion9.6
47chromophobe adenoma9.6
48pituitary adenoma9.6
49subacute bacterial endocarditis9.6
50retinal detachment9.6

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Symptoms for Scotoma

About this section

Drugs & Therapeutics for Scotoma

About this section

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RanibizumabapprovedPhase 3, Phase 1, Phase 2474347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
2
Bevacizumabapproved, investigationalPhase 31968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3Angiogenesis InhibitorsPhase 3, Phase 1, Phase 24143
4Angiogenesis Modulating AgentsPhase 3, Phase 1, Phase 24072
5Omega 3 Fatty AcidNutraceuticalPhase 3969
6Idebenoneapproved, investigationalPhase 22158186-27-9
7Trace ElementsPhase 25802
8Protective AgentsPhase 27190
9UbiquinonePhase 2139
10MicronutrientsPhase 25802
11
ImidaclopridPhase 2166105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
12AntioxidantsPhase 22928
13
Latanoprostapproved, investigational197130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
14
Luteinapproved, nutraceutical69127-40-26433159, 5368396
Synonyms:
(3R,3'R)-beta,beta-Carotene-3,3'-Diol, Lutein
(3R,3'R,6'R)-Lutein
(3R,3'R,6S)-4,5-Didehydro-5,6-Dihydro-beta,beta-Carotene-3,3'-Diol
3,3'-Dihydroxy-alpha-carotene
4,5-Didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol
All-trans-(+)-Xanthophyll
All-trans-Lutein
All-trans-Xanthophyll
 
Bo-Xan
Lutein
Lutein ester
Luteine
Phylloxanthin
Vegetable lutein
Vegetable luteol
beta,epsilon-Carotene-3,3'-diol
trans-Lutein
15
Diminazeneexperimental3536-71-0
Synonyms:
1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE
4,4'-(1-Triazene-1,3-diyl)bis-benzenecarboximidamide
 
4,4'-(Diazoamino)benzamidine
Diminazene aceturate
Diminazine
Diminazine aceturate
16Diminazene aceturate10
17Antiprotozoal Agents1986
18Antiparasitic Agents2127
19Anti-Infective Agents21402
20Liver Extracts3868
21Tissue Plasminogen Activator231
22Fibrinolytic Agents2317
23Plasminogen236

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis TherapyUnknown statusNCT01255774Phase 3
2Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic LesionsUnknown statusNCT01418820Phase 2, Phase 3
3Bevacizumab Versus Ranibizumab for Diabetic RetinopathyCompletedNCT00545870Phase 3
4A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular AdhesionCompletedNCT01889251Phase 3
5Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD).TerminatedNCT00987129Phase 3
6Scotoma Reduction in AMD Patients Treated With RanibizumabCompletedNCT00467935Phase 1, Phase 2
7Evaluation of Eye Movement Tracking Systems for Visual RehabilitationCompletedNCT00013429Phase 2
8Low Vision Study Comparing EV Training vs. CCTV for AMD RehabilitationCompletedNCT00971464Phase 2
9Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial)CompletedNCT00504400Phase 2
10Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic NeuropathyCompletedNCT00747487Phase 2
11Gene Therapy for Achromatopsia (CNGB3)RecruitingNCT03001310Phase 1, Phase 2
12Visuomotor Rehabilitation TrainingCompletedNCT01691027Early Phase 1
13A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus PhotographCompletedNCT01843582
14The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration TherapyCompletedNCT00921427Early Phase 1
15Detection of Topographic Residual Acuity in Patients With Age Related Macular DegenerationCompletedNCT00329277
16Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular DegenerationCompletedNCT00879671
17Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole SurgeryCompletedNCT00419185
18Age-related Normative Values for the Octopus 900 PerimeterCompletedNCT01518686
19Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV)RecruitingNCT02829606
20Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular OedemaRecruitingNCT02457884
21Sparing of the Fovea in Geographic Atrophy ProgressionRecruitingNCT02332343
22Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the RetinaRecruitingNCT02088151
23Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial FibrillationRecruitingNCT02424110
24Oxidative Stress and Endothelial Function in Pregnancy ComplicationsRecruitingNCT02603913
25Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma PatientsActive, not recruitingNCT00902109
26Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX PerimeterActive, not recruitingNCT01068938
27Clinical Study of LPI With Different Laser WavelengthsActive, not recruitingNCT02901730
28Clinical Study of LPI on Different Sites of IrisActive, not recruitingNCT02870504
29Treatment Trial for Acute Central Serous ChorioretinopathyEnrolling by invitationNCT02784665
30Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole SurgeryNot yet recruitingNCT02894424
31Telescope Exchange StudyNot yet recruitingNCT03011554
32Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular DegenerationNot yet recruitingNCT02747368
33Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration ComplicationsNot yet recruitingNCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

About this section

Genetic tests related to Scotoma:

id Genetic test Affiliating Genes
1 Scotoma26

Anatomical Context for Scotoma

About this section

MalaCards organs/tissues related to Scotoma:

35
Eye, Testes, Retina, Endothelial, Liver, Pituitary, Cortex

Animal Models for Scotoma or affiliated genes

About this section

Publications for Scotoma

About this section

Articles related to Scotoma:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Characteristics of the preferred retinal loci of better and worse seeing eyes of patients with a central scotoma. (27769327)
2016
2
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. (26060390)
2015
3
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. (24595065)
2014
4
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. (25313789)
2014
5
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. (23697959)
2013
6
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. (23620092)
2013
7
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. (23481153)
2013
8
Scotoma displacement in the macular mapping test as a tool for identification of preferred retinal loci. (22333854)
2012
9
Characteristics of optic disc morphology in glaucoma patients with parafoveal scotoma compared to peripheral scotoma. (22714895)
2012
10
Object detection in the ring scotoma of a monocular bioptic telescope. (21555615)
2011
11
Sildenafil improves scotoma after posterior cerebral infarctions: a case report. (20037762)
2010
12
Small effect of interline spacing on maximal reading speed in low-vision patients with central field loss irrespective of scotoma size. (19834038)
2010
13
Scotoma size reduction as an adaptive strategy in age-related macular degeneration. (20648088)
2010
14
Size scaling compensates for sensitivity loss produced by a simulated central scotoma in a shape-from-texture task. (21047750)
2010
15
Anatomical correlate of a persistent paracentral scotoma after an airbag injury. (19485304)
2009
16
Peculiar arcuate scotoma in pathologic myopia--optical coherence tomography to detect peripapillary neural tissue loss over the disc crescent. (15688158)
2005
17
Artificial scotoma-induced perceptual distortions are orientation dependent and short lived. (15137584)
2004
18
An unusual junctional scotoma. (12504743)
2002
19
Association of preoperative photoreceptor displacement and improved central scotoma after idiopathic macular hole surgery. (12414433)
2002
20
Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. (11730655)
2001
21
Filling-in of the foveal blue scotoma. (11704235)
2001
22
Compression of the prechiasmatic optic nerve produces a junctional scotoma. (10970241)
2000
23
Effects of cataract and scotoma on visual acuity: a simulation study. (10445638)
1999
24
Incongruous homonymous hemianopic scotoma. (10371081)
1999
25
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
26
Resolution of an absolute scotoma after spontaneous disappearance of idiopathic full-thickness macular hole. (8023867)
1994
27
Contrast sensitivity peripheral to an absolute central scotoma in age-related macular degeneration and the influence of a yellow or an orange filter. (8299504)
1993
28
Is there a systematic location for the pseudo-fovea in patients with central scotoma? (8333174)
1993
29
A cluster and scotoma analysis based on empiric criteria. (8299977)
1993
30
Xanthic scotoma and yellow foveolar shadow caused by a pseudo-operculum after vitreofoveal separation. (1410833)
1992
31
Effect of a scotoma on eye movements during visual search. (2622676)
1989
32
Increase of the short-term fluctuation of the differential light threshold around a physiologic scotoma. (2596568)
1989
33
The effect of a foveal scotoma on the visual lobe. (3211561)
1988
34
Residual vision in a scotoma. A follow-up study of 'form' discrimination. (3801855)
1987
35
Clinical spatial contrast sensitivity measurement: implications of artificial scotoma experiments. (3953753)
1986
36
Scanning characters and reading with a central scotoma. (4083327)
1985
37
Intactness of useful central vision during migraine scotoma. (7390804)
1980
38
Central versus peripheral vision: evaluation of the residual function resulting from a uniocular macular scotoma. (742652)
1978
39
The limitations of kinetic perimetry in early scotoma detection. (662282)
1978
40
Scotoma due to arterial hypotension. (4800601)
1973
41
The migrainous scintillating scotoma. (5067127)
1972
42
Migraine equivalent: the scintillating scotoma. (5163773)
1971
43
Differential diagnosis of the arcuate scotoma. (5763851)
1969
44
Occlusion of a cilioretinal artery with permanent central scotoma. (13873502)
1962
45
The temporal half-moon: a self-observation in flimmer scotoma. (13217784)
1954
46
Ring Scotoma after Retrobulbar Neuritis. (19993471)
1947
47
Scotoma as a complication of decompression sickness. (20997673)
1946
48
A Scotoma Associated with Menstruation. (16693242)
1940
49
BITEMPORAL HEMIOPIA: THE LATER STAGES AND THE SPECIAL FEATURES OF THE SCOTOMA: With an examination of current theories of the mechanism of production of the field defects. (18167670)
1917
50
BITEMPORAL HEMIOPIA: THE LATER STAGES AND THE SPECIAL FEATURES OF THE SCOTOMA: With an examination of current theories of the mechanism of production of the field defects. (18167666)
1917

Variations for Scotoma

About this section

Expression for genes affiliated with Scotoma

About this section
Search GEO for disease gene expression data for Scotoma.

Pathways for genes affiliated with Scotoma

About this section

GO Terms for genes affiliated with Scotoma

About this section

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:000574710.0MT-ND4, SNCA
2mitochondrial inner membraneGO:00057439.4MT-ND4, OPA1, TMEM126A

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to stimulusGO:00508969.5CYP4V2, RDH5
2retinoid metabolic processGO:00015239.2ABCA4, CYP4V2, RDH5
3agingGO:00075689.1MT-ND4, OPA1, SNCA
4visual perceptionGO:00076018.3ABCA4, CYP4V2, OPA1, RDH5

Sources for Scotoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet