Aliases & Classifications for Scotoma

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Aliases & Descriptions for Scotoma:

Name: Scotoma 10 12
Generalized Visual Field Contraction 10
Arcuate Visual Field Defects 10
Blind Spot Area Scotoma Nos 10
Enlarged Paracaecal Scotoma 10
 
Scotoma of Blind Spot Area 10
Enlarged Angioscotoma 10
Enlarged Blind Spot 10
Constriction 10
Sector 10


Classifications:



External Ids:

Disease Ontology10 DOID:9335
SNOMED-CT59 193673000, 33970004
ICD9CM29 368.44

Summaries for Scotoma

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Wikipedia:68 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards based summary: Scotoma, also known as generalized visual field contraction, is related to optic atrophy plus syndrome and macular degeneration, age-related, 1. An important gene associated with Scotoma is OPA1 (Optic Atrophy 1 (Autosomal Dominant)), and among its related pathways is the visual cycle I (vertebrates). Affiliated tissues include eye, testes and pituitary, and related mouse phenotype cardiovascular system.

Related Diseases for Scotoma

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Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Symptoms for Scotoma

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Drugs & Therapeutics for Scotoma

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Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bevacizumabapproved, investigationalPhase 31820216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2Omega 3 Fatty AcidNutraceuticalPhase 3890
3
ImidaclopridPhase 2128105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
4idebenonePhase 217
5
Latanoprostapproved, investigational180130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
6
Luteinapproved, nutraceutical69127-40-25368396, 6433159
Synonyms:
(3R,3'R)-beta,beta-Carotene-3,3'-Diol, Lutein
(3R,3'R,6'R)-Lutein
(3R,3'R,6S)-4,5-Didehydro-5,6-Dihydro-beta,beta-Carotene-3,3'-Diol
3,3'-Dihydroxy-alpha-carotene
4,5-Didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol
All-trans-(+)-Xanthophyll
All-trans-Lutein
All-trans-Xanthophyll
 
Bo-Xan
Lutein
Lutein ester
Luteine
Phylloxanthin
SID548587
Vegetable lutein
Vegetable luteol
beta,epsilon-Carotene-3,3'-diol
trans-Lutein
7Diminazene aceturate10
8Tissue Plasminogen Activator198
9Plasminogen177

Interventional clinical trials:

(show all 25)
idNameStatusNCT IDPhase
1Bevacizumab Versus Ranibizumab for Diabetic RetinopathyCompletedNCT00545870Phase 3
2A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular AdhesionCompletedNCT01889251Phase 3
3Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis TherapyRecruitingNCT01255774Phase 3
4Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic LesionsActive, not recruitingNCT01418820Phase 2, Phase 3
5Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD).TerminatedNCT00987129Phase 3
6Scotoma Reduction in AMD Patients Treated With RanibizumabCompletedNCT00467935Phase 1, Phase 2
7Evaluation of Eye Movement Tracking Systems for Visual RehabilitationCompletedNCT00013429Phase 2
8Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial)CompletedNCT00504400Phase 2
9Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic NeuropathyCompletedNCT00747487Phase 2
10Low Vision Study Comparing EV Training vs. CCTV for AMD RehabilitationCompletedNCT00971464Phase 2
11Visuomotor Rehabilitation TrainingCompletedNCT01691027Phase 0
12A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus PhotographCompletedNCT01843582
13The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration TherapyCompletedNCT00921427Phase 0
14Detection of Topographic Residual Acuity in Patients With Age Related Macular DegenerationCompletedNCT00329277
15Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole SurgeryCompletedNCT00419185
16Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular DegenerationCompletedNCT00879671
17Age-related Normative Values for the Octopus 900 PerimeterCompletedNCT01518686
18Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular OedemaRecruitingNCT02457884
19Sparing of the Fovea in Geographic Atrophy ProgressionRecruitingNCT02332343
20Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the RetinaRecruitingNCT02088151
21Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial FibrillationRecruitingNCT02424110
22Oxidative Stress and Endothelial Function in Pregnancy ComplicationsRecruitingNCT02603913
23Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma PatientsActive, not recruitingNCT00902109
24Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX PerimeterActive, not recruitingNCT01068938
25Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration ComplicationsNot yet recruitingNCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

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Anatomical Context for Scotoma

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MalaCards organs/tissues related to Scotoma:

33
Eye, Testes, Pituitary, Cortex, Occipital lobe, Retina, Brain

Animal Models for Scotoma or affiliated genes

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MGI Mouse Phenotypes related to Scotoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4ABCA4, KCNMA1, OPA1, SLC22A3, SNCA

Publications for Scotoma

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Articles related to Scotoma:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. (26476213)
2015
2
Stop before you saccade: Looking into an artificial peripheral scotoma. (26067525)
2015
3
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. (24595065)
2014
4
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. (23697959)
2013
5
Patient awareness of binocular central scotoma in age-related macular degeneration. (22863789)
2012
6
FUNDUS AUTOFLUORESCENCE IMAGING IN A PATIENT WITH RAPIDLY DEVELOPING SCOTOMA. (23293707)
2012
7
Scotoma displacement in the macular mapping test as a tool for identification of preferred retinal loci. (22333854)
2012
8
Treating our societal scotoma: the case for investing in geriatrics, our nation's future, and our patients. (22547475)
2012
9
Facial pain, scotomas and hemihypaesthesia as presenting symptoms of type A aortic dissection in a patient with migraine with aura. (22407662)
2012
10
Object detection in the ring scotoma of a monocular bioptic telescope. (21555615)
2011
11
Sildenafil improves scotoma after posterior cerebral infarctions: a case report. (20037762)
2010
12
Small effect of interline spacing on maximal reading speed in low-vision patients with central field loss irrespective of scotoma size. (19834038)
2010
13
Scotoma size reduction as an adaptive strategy in age-related macular degeneration. (20648088)
2010
14
Microstrabismus: Fixation point scotoma, a perimetric artefact. (19200806)
2009
15
A novel high-resolution kinetic method for visual field mapping of scotoma in age-related macular degeneration. (15497550)
2004
16
Unveiling the foveal blue scotoma through an afterimage. (14659964)
2004
17
Modified astigmatism dial diagram for locating eccentric fixation in patients with central scotoma. (12749291)
2003
18
An unusual junctional scotoma. (12504743)
2002
19
Iatrogenic ring scotoma after laser in situ keratomileusis. (12388042)
2002
20
The effects of simulated cataract on reading with normal vision and simulated central scotoma. (10755163)
1999
21
Compression of the prechiasmatic optic nerve produces a junctional scotoma. (10458197)
1999
22
Effects of cataract and scotoma on visual acuity: a simulation study. (10445638)
1999
23
Residual Vision in Multiple Retinal Locations within a Scotoma: Implications for Blindsight. (23962011)
1997
24
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
25
Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. (8841306)
1996
26
Responses of cells in monkey visual cortex during perceptual filling-in of an artificial scotoma. (7477262)
1995
27
Scotoma perception in white-noise-field campimetry and postchiasmal visual pathway lesions. (7492935)
1995
28
Resolution of an absolute scotoma after spontaneous disappearance of idiopathic full-thickness macular hole. (8023867)
1994
29
Contrast sensitivity peripheral to an absolute central scotoma in age-related macular degeneration and the influence of a yellow or an orange filter. (8299504)
1993
30
Is there a systematic location for the pseudo-fovea in patients with central scotoma? (8333174)
1993
31
Resolution of an absolute scotoma and improvement of relative scotomata after successful macular hole surgery. (8352296)
1993
32
Effect of a scotoma on eye movements during visual search. (2622676)
1989
33
Increase of the short-term fluctuation of the differential light threshold around a physiologic scotoma. (2596568)
1989
34
The effect of a foveal scotoma on the visual lobe. (3211561)
1988
35
Residual vision in a scotoma. A follow-up study of 'form' discrimination. (3801855)
1987
36
Clinical spatial contrast sensitivity measurement: implications of artificial scotoma experiments. (3953753)
1986
37
Junction scotoma and involvement of the optochiasmal junction. (4010084)
1985
38
Visual field recovery from scotoma in patients with postgeniculate damage. A review of 55 cases. (4005527)
1985
39
Central versus peripheral vision: evaluation of the residual function resulting from a uniocular macular scotoma. (742652)
1978
40
Scotoma due to arterial hypotension. (4800601)
1973
41
The migrainous scintillating scotoma. (5067127)
1972
42
Binocular suppression scotoma: its role in phorias and intermittent tropias. (5425262)
1970
43
Differential diagnosis of the arcuate scotoma. (5763851)
1969
44
Radial peripapillary capillaries of the retina. II. Possible role in Bjerrum scotoma. (5635900)
1968
45
THE BJERRUM SCOTOMA. (14271000)
1965
46
The temporal half-moon: a self-observation in flimmer scotoma. (13217784)
1954
47
Ring Scotoma after Retrobulbar Neuritis. (19993471)
1947
48
Central Scotoma in Anterior Uveitis: A Further Contribution. (16692615)
1922
49
CENTRAL SCOTOMA IN ANTERIOR UVEITIS. (18168184)
1922
50
BITEMPORAL HEMIOPIA: THE LATER STAGES AND THE SPECIAL FEATURES OF THE SCOTOMA: With an examination of current theories of the mechanism of production of the field defects. (18167670)
1917

Variations for Scotoma

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Expression for genes affiliated with Scotoma

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Search GEO for disease gene expression data for Scotoma.

Pathways for genes affiliated with Scotoma

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Pathways related to Scotoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4ABCA4, RDH5

GO Terms for genes affiliated with Scotoma

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Cellular components related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:00431959.6KCNMA1, SNCA

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoid metabolic processGO:00015239.5ABCA4, RDH5
2phototransduction, visible lightGO:00076039.3ABCA4, RDH5
3visual perceptionGO:00076018.6ABCA4, CYP4V2, OPA1, RDH5

Sources for Scotoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet