Aliases & Classifications for Scotoma

Aliases & Descriptions for Scotoma:

Name: Scotoma 12 29 14
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
SNOMED-CT 64 193673000 33970004

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and migraine, familial hemiplegic, 2. An important gene associated with Scotoma is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and the visual cycle I (vertebrates). The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and pituitary.

Wikipedia : 71 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Related Disease Score Top Affiliating Genes
1 optic atrophy 1 10.9
2 migraine, familial hemiplegic, 2 10.7
3 migraine, familial hemiplegic, 3 10.7
4 optic atrophy 7 10.7
5 migraine, familial hemiplegic, 1 10.7
6 leber optic atrophy 10.7
7 birdshot chorioretinopathy 10.7
8 familial hemiplegic migraine 10.7
9 retinitis 10.2
10 cone-rod dystrophy 3 10.1 ABCA4 KCNMA1
11 allergic contact dermatitis of eyelid 10.1 MT-ND4 OPA1
12 alopecia, androgenetic, 2 10.0 MT-ND4 OPA1 TMEM126A
13 hypopigmentation of eyelid 10.0 MT-ND4 SNCA
14 autoimmune gastrointestinal dysmotility 10.0 OPA1 TMEM126A
15 lipoprotein lipase deficiency 10.0 MT-ND4 SNCA
16 growth hormone deficiency, isolated partial 10.0 MT-ND4 SNCA
17 hypertrichosis terminalis, generalized, with or without gingival hyperplasia 9.9 ABCA4 RDH5
18 neuritis 9.9
19 spinocerebellar ataxia, autosomal recessive 15 9.8 MT-ND4 OPA1 SNCA TMEM126A
20 macular holes 9.8
21 headache 9.8
22 systemic lupus erythematosus 9.7
23 stargardt disease 9.7
24 cataract 9.7
25 amblyopia 9.7
26 open-angle glaucoma 9.7
27 choroiditis 9.7
28 uveitis 9.7
29 cerebritis 9.7
30 strabismus 9.7
31 adenoma 9.7
32 lupus erythematosus 9.7
33 anterior uveitis 9.7
34 aneurysm 9.7
35 pituitary tumors 9.7
36 hepatitis c virus 9.6
37 hepatitis 9.6
38 retinal vein occlusion 9.6
39 sinusitis 9.6
40 cytomegalovirus retinitis 9.6
41 migraine with aura 9.6
42 neuroretinitis 9.6
43 endocarditis 9.6
44 astigmatism 9.6
45 myopia 9.6
46 optic neuritis 9.6
47 hepatitis c 9.6
48 melanoma 9.6
49 central retinal vein occlusion 9.6
50 chromophobe adenoma 9.6

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 3,Phase 1,Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3
3 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2
4 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2
5 Omega 3 Fatty Acid Nutraceutical Phase 3
6 Idebenone Approved, Investigational Phase 2 58186-27-9
7 Ubiquinone Phase 2
8
Imidacloprid Phase 2 105827-78-9 86418
9 Trace Elements Phase 2
10 Protective Agents Phase 2
11 Micronutrients Phase 2
12 Antioxidants Phase 2
13
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
14
Lutein Approved, Nutraceutical 127-40-2 6433159 5368396
15
Diminazene Experimental 536-71-0
16 Diminazene aceturate
17 Anti-Infective Agents
18 Antiparasitic Agents
19 Antiprotozoal Agents
20 Liver Extracts
21 Tissue Plasminogen Activator
22 Plasminogen
23 Fibrinolytic Agents

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Unknown status NCT01255774 Phase 3
2 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Unknown status NCT01418820 Phase 2, Phase 3
3 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3
4 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3
5 Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD). Terminated NCT00987129 Phase 3
6 Scotoma Reduction in AMD Patients Treated With Ranibizumab Completed NCT00467935 Phase 1, Phase 2
7 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
8 Low Vision Study Comparing EV Training vs. CCTV for AMD Rehabilitation Completed NCT00971464 Phase 2
9 Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial) Completed NCT00504400 Phase 2
10 Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy Completed NCT00747487 Phase 2
11 Gene Therapy for Achromatopsia (CNGB3) Recruiting NCT03001310 Phase 1, Phase 2
12 Visuomotor Rehabilitation Training Completed NCT01691027 Early Phase 1
13 A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph Completed NCT01843582
14 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
15 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277
16 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
17 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671
18 A Clinical Study of Fundus Findings in Toxaemia of Pregnancy Completed NCT03076619
19 Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery Completed NCT00419185
20 Age-related Normative Values for the Octopus 900 Perimeter Completed NCT01518686
21 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
22 Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV) Recruiting NCT02829606
23 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema Recruiting NCT02457884
24 Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery Recruiting NCT02894424
25 Telescope Exchange Study Recruiting NCT03011554
26 Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina Recruiting NCT02088151
27 Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial Fibrillation Recruiting NCT02424110
28 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
29 Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients Active, not recruiting NCT00902109
30 Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter Active, not recruiting NCT01068938
31 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730
32 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504
33 Treatment Trial for Acute Central Serous Chorioretinopathy Enrolling by invitation NCT02784665
34 Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration Enrolling by invitation NCT02747368
35 Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration Complications Not yet recruiting NCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

Genetic tests related to Scotoma:

id Genetic test Affiliating Genes
1 Scotoma 29

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

39
Eye, Testes, Pituitary, Cortex, Brain, Retina, Occipital Lobe

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 216)
id Title Authors Year
1
Scotoma Visibility and Reading Rate with Bilateral Central Scotomas. ( 28030516 )
2016
2
MAPPING THE DENSE SCOTOMA AND ITS ENLARGEMENT IN STARGARDT DISEASE. ( 26909568 )
2016
3
Characteristics of the preferred retinal loci of better and worse seeing eyes of patients with a central scotoma. ( 27769327 )
2016
4
Progressing Scintillating Scotoma Captured on Automated Visual Field Testing. ( 26854039 )
2016
5
The Effects of Nocturnal Dip and Blood Pressure Variability on Paracentral Scotoma in Early Open-Angle Glaucoma. ( 27128963 )
2016
6
Optic Disk Pit with Sudden Central Visual Field Scotoma. ( 27872777 )
2016
7
Assessing the GOANNA Visual Field Algorithm Using Artificial Scotoma Generation on Human Observers. ( 27622080 )
2016
8
Comparison of retinal vessel diameter between open-angle glaucoma patients with initial parafoveal scotoma and peripheral nasal step. ( 27916714 )
2016
9
Structure-Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma. ( 26848881 )
2016
10
Long-lasting, dense scotoma under light-adapted conditions in patient with multiple evanescent white dot syndrome. ( 26678272 )
2015
11
Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. ( 26476213 )
2015
12
Comparison of Risk Factors for Initial Central Scotoma versus Initial Peripheral Scotoma in Normal-tension Glaucoma. ( 25829826 )
2015
13
Scotoma analysis of 10-2 visual field testing with a red target in screening for hydroxychloroquine retinopathy. ( 26316692 )
2015
14
Microperimetry biofeedback training in a patient with bilateral myopic macular degeneration with central scotoma. ( 26265646 )
2015
15
Random word recognition chart helps scotoma assessment in low vision. ( 25946100 )
2015
16
Optimal point of fixation to faces for vision with a simulated central scotoma. ( 26326621 )
2015
17
fMRI of the rod scotoma elucidates cortical rod pathways and implications for lesion measurements. ( 25848028 )
2015
18
Stop before you saccade: Looking into an artificial peripheral scotoma. ( 26067525 )
2015
19
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. ( 26060390 )
2015
20
Size of the foveal blue scotoma related to the shape of the foveal pit but not to macular pigment. ( 25449158 )
2015
21
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. ( 24595065 )
2014
22
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma: Reply. ( 25313790 )
2014
23
Xanthic scotoma. ( 25256032 )
2014
24
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. ( 24045572 )
2014
25
Reading with peripheral vision: a comparison of reading dynamic scrolling and static text with a simulated central scotoma. ( 24680772 )
2014
26
Central scotoma and 'muddled thinking' as migraine aura. ( 24045570 )
2014
27
Adaptation to a simulated central scotoma during visual search training. ( 24456805 )
2014
28
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. ( 25313789 )
2014
29
Paracentral scotoma in glaucoma detected by 10-2 but not by 24-2 perimetry. ( 24442888 )
2014
30
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. ( 23697959 )
2013
31
A behavioral task for the validation of a gaze-contingent simulated scotoma. ( 23526257 )
2013
32
Scotomas in molecular virology and epidemiology of hepatitis C virus. ( 24307785 )
2013
33
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. ( 23481153 )
2013
34
Fixation stability and scotoma mapping for patients with low vision. ( 23334309 )
2013
35
Arcuate scotoma associated with traction at the optic disc. ( 23449516 )
2013
36
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. ( 23620092 )
2013
37
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates. ( 24357841 )
2013
38
Rehabilitative approach in patients with ring scotoma. ( 24093190 )
2013
39
The effect of strabismus on object detection in the ring scotoma of a monocular bioptic telescope. ( 23639041 )
2013
40
Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma. ( 23972895 )
2013
41
Characteristics of optic disc morphology in glaucoma patients with parafoveal scotoma compared to peripheral scotoma. ( 22714895 )
2012
42
Patient awareness of binocular central scotoma in age-related macular degeneration. ( 22863789 )
2012
43
FUNDUS AUTOFLUORESCENCE IMAGING IN A PATIENT WITH RAPIDLY DEVELOPING SCOTOMA. ( 23293707 )
2012
44
Decreased vision and junctional scotoma from pituicytoma. ( 22740829 )
2012
45
Recommendations for the treatment of hypertension in the elderly and very elderly--a scotoma within international guidelines. ( 22573500 )
2012
46
Lack of spatial remapping of the visual field surrounding a monocular scotoma. ( 21682767 )
2012
47
Opposite effects of perceptual and working memory load on perceptual filling-in of an artificial scotoma. ( 24168648 )
2012
48
Chronic disabling pain: a scotoma in the eye of both pain medicine and rehabilitation in Europe. ( 23159955 )
2012
49
Facial pain, scotomas and hemihypaesthesia as presenting symptoms of type A aortic dissection in a patient with migraine with aura. ( 22407662 )
2012
50
Treating our societal scotoma: the case for investing in geriatrics, our nation's future, and our patients. ( 22547475 )
2012

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

GO Terms for Scotoma

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.35 MT-ND4 OPA1 SNCA TMEM126A VARS
2 mitochondrial respiratory chain complex I GO:0005747 8.62 MT-ND4 SNCA

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.62 CYP4V2 MT-ND4 RDH5 SNCA
2 response to stimulus GO:0050896 9.56 ABCA4 CYP4V2 OPA1 RDH5
3 aging GO:0007568 9.33 MT-ND4 OPA1 SNCA
4 retinoid metabolic process GO:0001523 9.13 ABCA4 CYP4V2 RDH5
5 visual perception GO:0007601 8.92 ABCA4 CYP4V2 OPA1 RDH5

Molecular functions related to Scotoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.92 CYP4V2 MT-ND4 RDH5 SNCA

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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