Aliases & Classifications for Scotoma

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Aliases & Descriptions for Scotoma:

Name: Scotoma 11 13 25
Generalized Visual Field Contraction or Constriction 11
Sector or Arcuate Visual Field Defects 11
Enlarged Paracaecal Scotoma 11
 
Scotoma of Blind Spot Area 11
Blind Spot Area Scotoma 11
Enlarged Angioscotoma 11
Enlarged Blind Spot 11

Classifications:



External Ids:

Disease Ontology11 DOID:9335
SNOMED-CT60 193673000, 33970004

Summaries for Scotoma

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Wikipedia:69 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

MalaCards based summary: Scotoma, also known as generalized visual field contraction or constriction, is related to retinitis and noninfectious dermatoses of eyelid. An important gene associated with Scotoma is OPA1 (OPA1, Mitochondrial Dynamin Like GTPase), and among its related pathways is the visual cycle I (vertebrates). Affiliated tissues include eye, testes and retina.

Related Diseases for Scotoma

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Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis10.3
2noninfectious dermatoses of eyelid10.3MT-ND4, TMEM126A
3dandy-walker malformation with nasopharyngeal teratoma and diaphragmatic hernia10.3OPA1, TMEM126A
4hyperinsulinism10.2ABCA4, KCNMA1
5patau syndrome10.1MT-ND4, SNCA
6mitochondrial neurogastrointestinal encephalopathy disease10.1MT-ND4, OPA1
7optic atrophy 110.0
8neuritis10.0
9hypertrichosis terminalis, generalized, with or without gingival hyperplasia10.0ABCA4, RDH5
10macular holes9.9
11headache9.9
12migraine, familial hemiplegic, 29.9
13migraine, familial hemiplegic, 39.9
14optic atrophy 79.9
15migraine, familial hemiplegic, 19.9
16familial hemiplegic migraine9.9
17leber hereditary optic neuropathy9.9
18impetigo herpetiformis9.8ABCA4, RDH5
19chronic intestinal vascular insufficiency9.8MT-ND4, SNCA
20systemic lupus erythematosus9.8
21stargardt disease9.8
22cataract9.8
23amblyopia9.8
24choroiditis9.8
25uveitis9.8
26cerebritis9.8
27strabismus9.8
28adenoma9.8
29lupus erythematosus9.8
30anterior uveitis9.8
31aneurysm9.8
32pituitary tumors9.8
33posterior polar cataract9.8ABCA4, RDH5
34hepatitis c virus9.7
35hepatitis9.7
36retinal vein occlusion9.7
37sinusitis9.7
38cytomegalovirus retinitis9.7
39migraine with aura9.7
40neuroretinitis9.7
41endocarditis9.7
42open-angle glaucoma9.7
43astigmatism9.7
44myopia9.7
45optic neuritis9.7
46hepatitis c9.7
47melanoma9.7
48central retinal vein occlusion9.7
49chromophobe adenoma9.7
50pituitary adenoma9.7

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to scotoma

Symptoms for Scotoma

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Drugs & Therapeutics for Scotoma

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Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BevacizumabPhase 31938216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
2
RanibizumabPhase 3, Phase 1, Phase 2469347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
3
imidaclopridPhase 2154105827-78-986418
Synonyms:
(e)-imidacloprid
(z)-imidacloprid
1-((6-Chloro-3-pyridyl)methyl)-N-nitro-2-imidazolidinimine
1-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine
1-[(6-Chloro-3-pyridinyl)methyl]-4,5-dihydro-N-nitro-1H-imidazol-2-amine, 9CI
Admire
Advantage
Advantage flea adulticide
Bayer brand of imidacloprid
 
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid (old RN)
Imidacloprid [iso]
Merit
Merit (insecticide)
Premise 75
Provado
4UbiquinonePhase 2132
5idebenonePhase 22158186-27-9
6
Latanoprost196130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
7
XanthophyllNutraceutical69127-40-26433159, 5368396
Synonyms:
(3R,3'R)-beta,beta-Carotene-3,3'-Diol, Lutein
(3R,3'R,6'R)-Lutein
(3R,3'R,6S)-4,5-Didehydro-5,6-Dihydro-beta,beta-Carotene-3,3'-Diol
3,3'-Dihydroxy-alpha-carotene
4,5-Didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol
All-trans-(+)-Xanthophyll
All-trans-Lutein
All-trans-Xanthophyll
 
Bo-Xan
Lutein
Lutein ester
Luteine
Phylloxanthin
Vegetable lutein
Vegetable luteol
beta,epsilon-Carotene-3,3'-diol
trans-Lutein

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Bevacizumab Versus Ranibizumab for Diabetic RetinopathyCompletedNCT00545870Phase 3
2A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular AdhesionCompletedNCT01889251Phase 3
3Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis TherapyRecruitingNCT01255774Phase 3
4Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic LesionsActive, not recruitingNCT01418820Phase 2, Phase 3
5Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD).TerminatedNCT00987129Phase 3
6Scotoma Reduction in AMD Patients Treated With RanibizumabCompletedNCT00467935Phase 1, Phase 2
7Evaluation of Eye Movement Tracking Systems for Visual RehabilitationCompletedNCT00013429Phase 2
8Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial)CompletedNCT00504400Phase 2
9Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic NeuropathyCompletedNCT00747487Phase 2
10Low Vision Study Comparing EV Training vs. CCTV for AMD RehabilitationCompletedNCT00971464Phase 2
11Visuomotor Rehabilitation TrainingCompletedNCT01691027Phase 0
12A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus PhotographCompletedNCT01843582
13The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration TherapyCompletedNCT00921427Phase 0
14Detection of Topographic Residual Acuity in Patients With Age Related Macular DegenerationCompletedNCT00329277
15Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole SurgeryCompletedNCT00419185
16Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular DegenerationCompletedNCT00879671
17Age-related Normative Values for the Octopus 900 PerimeterCompletedNCT01518686
18Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV)RecruitingNCT02829606
19Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular OedemaRecruitingNCT02457884
20Sparing of the Fovea in Geographic Atrophy ProgressionRecruitingNCT02332343
21Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the RetinaRecruitingNCT02088151
22Treatment Trial for Acute Central Serous ChorioretinopathyRecruitingNCT02784665
23Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial FibrillationRecruitingNCT02424110
24Oxidative Stress and Endothelial Function in Pregnancy ComplicationsRecruitingNCT02603913
25Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma PatientsActive, not recruitingNCT00902109
26Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX PerimeterActive, not recruitingNCT01068938
27Clinical Study of LPI With Different Laser WavelengthsActive, not recruitingNCT02901730
28Clinical Study of LPI on Different Sites of IrisActive, not recruitingNCT02870504
29Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole SurgeryNot yet recruitingNCT02894424
30Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular DegenerationNot yet recruitingNCT02747368
31Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration ComplicationsNot yet recruitingNCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

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Genetic tests related to Scotoma:

id Genetic test Affiliating Genes
1 Scotoma25

Anatomical Context for Scotoma

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MalaCards organs/tissues related to Scotoma:

34
Eye, Testes, Retina, Endothelial, Pituitary, Cortex, Brain

Animal Models for Scotoma or affiliated genes

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Publications for Scotoma

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Articles related to Scotoma:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. (26060390)
2015
2
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. (24595065)
2014
3
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. (25313789)
2014
4
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. (23697959)
2013
5
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. (23620092)
2013
6
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. (23481153)
2013
7
Scotoma displacement in the macular mapping test as a tool for identification of preferred retinal loci. (22333854)
2012
8
Characteristics of optic disc morphology in glaucoma patients with parafoveal scotoma compared to peripheral scotoma. (22714895)
2012
9
Object detection in the ring scotoma of a monocular bioptic telescope. (21555615)
2011
10
Sildenafil improves scotoma after posterior cerebral infarctions: a case report. (20037762)
2010
11
Small effect of interline spacing on maximal reading speed in low-vision patients with central field loss irrespective of scotoma size. (19834038)
2010
12
Scotoma size reduction as an adaptive strategy in age-related macular degeneration. (20648088)
2010
13
Size scaling compensates for sensitivity loss produced by a simulated central scotoma in a shape-from-texture task. (21047750)
2010
14
Anatomical correlate of a persistent paracentral scotoma after an airbag injury. (19485304)
2009
15
Occurrence of reversible bilateral scotoma 1 hour after single-pulse transcranial magnetic stimulation: a case report. (17388724)
2007
16
Peculiar arcuate scotoma in pathologic myopia--optical coherence tomography to detect peripapillary neural tissue loss over the disc crescent. (15688158)
2005
17
Artificial scotoma-induced perceptual distortions are orientation dependent and short lived. (15137584)
2004
18
An unusual junctional scotoma. (12504743)
2002
19
Association of preoperative photoreceptor displacement and improved central scotoma after idiopathic macular hole surgery. (12414433)
2002
20
Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. (11730655)
2001
21
Filling-in of the foveal blue scotoma. (11704235)
2001
22
Compression of the prechiasmatic optic nerve produces a junctional scotoma. (10970241)
2000
23
Effects of cataract and scotoma on visual acuity: a simulation study. (10445638)
1999
24
Incongruous homonymous hemianopic scotoma. (10371081)
1999
25
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
26
Resolution of an absolute scotoma after spontaneous disappearance of idiopathic full-thickness macular hole. (8023867)
1994
27
Contrast sensitivity peripheral to an absolute central scotoma in age-related macular degeneration and the influence of a yellow or an orange filter. (8299504)
1993
28
Is there a systematic location for the pseudo-fovea in patients with central scotoma? (8333174)
1993
29
A cluster and scotoma analysis based on empiric criteria. (8299977)
1993
30
Xanthic scotoma and yellow foveolar shadow caused by a pseudo-operculum after vitreofoveal separation. (1410833)
1992
31
Effect of a scotoma on eye movements during visual search. (2622676)
1989
32
Increase of the short-term fluctuation of the differential light threshold around a physiologic scotoma. (2596568)
1989
33
The effect of a foveal scotoma on the visual lobe. (3211561)
1988
34
Residual vision in a scotoma. A follow-up study of 'form' discrimination. (3801855)
1987
35
Clinical spatial contrast sensitivity measurement: implications of artificial scotoma experiments. (3953753)
1986
36
Scanning characters and reading with a central scotoma. (4083327)
1985
37
Intactness of useful central vision during migraine scotoma. (7390804)
1980
38
Central versus peripheral vision: evaluation of the residual function resulting from a uniocular macular scotoma. (742652)
1978
39
The limitations of kinetic perimetry in early scotoma detection. (662282)
1978
40
Scotoma due to arterial hypotension. (4800601)
1973
41
The migrainous scintillating scotoma. (5067127)
1972
42
Migraine equivalent: the scintillating scotoma. (5163773)
1971
43
Differential diagnosis of the arcuate scotoma. (5763851)
1969
44
Occlusion of a cilioretinal artery with permanent central scotoma. (13873502)
1962
45
The temporal half-moon: a self-observation in flimmer scotoma. (13217784)
1954
46
Ring Scotoma after Retrobulbar Neuritis. (19993471)
1947
47
Scotoma as a complication of decompression sickness. (20997673)
1946
48
A Scotoma Associated with Menstruation. (16693242)
1940
49
BITEMPORAL HEMIOPIA: THE LATER STAGES AND THE SPECIAL FEATURES OF THE SCOTOMA: With an examination of current theories of the mechanism of production of the field defects. (18167670)
1917
50
BITEMPORAL HEMIOPIA: THE LATER STAGES AND THE SPECIAL FEATURES OF THE SCOTOMA: With an examination of current theories of the mechanism of production of the field defects. (18167666)
1917

Variations for Scotoma

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Expression for genes affiliated with Scotoma

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Search GEO for disease gene expression data for Scotoma.

Pathways for genes affiliated with Scotoma

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Pathways related to Scotoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4ABCA4, RDH5

GO Terms for genes affiliated with Scotoma

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Cellular components related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IGO:000574710.2MT-ND4, SNCA
2mitochondrial inner membraneGO:00057439.3MT-ND4, OPA1, TMEM126A
3mitochondrionGO:00057398.4MT-ND4, OPA1, SNCA, TMEM126A, VARS

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1retinoid metabolic processGO:00015239.6ABCA4, RDH5
2visual perceptionGO:00076019.1ABCA4, OPA1, RDH5
3agingGO:00075688.9MT-ND4, OPA1, SNCA

Sources for Scotoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet