Aliases & Classifications for Scotoma

MalaCards integrated aliases for Scotoma:

Name: Scotoma 12 29 14
Generalized Visual Field Contraction or Constriction 12
Sector or Arcuate Visual Field Defects 12
Enlarged Paracaecal Scotoma 12
Scotoma of Blind Spot Area 12
Blind Spot Area Scotoma 12
Enlarged Angioscotoma 12
Enlarged Blind Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9335
SNOMED-CT 64 193673000 33970004

Summaries for Scotoma

MalaCards based summary : Scotoma, also known as generalized visual field contraction or constriction, is related to optic atrophy 1 and migraine, familial hemiplegic, 2. An important gene associated with Scotoma is TMEM126A (Transmembrane Protein 126A), and among its related pathways/superpathways is the visual cycle I (vertebrates). The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina.

Wikipedia : 72 A scotoma (Greek σκότος/skótos, darkness; plural: scotomas or scotomata) is an area of partial... more...

Related Diseases for Scotoma

Diseases related to Scotoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 optic atrophy 1 10.9
2 migraine, familial hemiplegic, 2 10.7
3 migraine, familial hemiplegic, 3 10.7
4 optic atrophy 7 10.7
5 migraine, familial hemiplegic, 1 10.7
6 leber optic atrophy 10.7
7 mohr-tranebjaerg syndrome 10.7
8 cone-rod dystrophy 10.7
9 birdshot chorioretinopathy 10.7
10 familial hemiplegic migraine 10.7
11 autosomal dominant optic atrophy plus syndrome 10.7
12 retinitis pigmentosa 19 10.3 ABCA4 KCNMA1
13 retinitis 10.2
14 allergic contact dermatitis of eyelid 10.2 MT-ND4 OPA1
15 androgen insensitivity 10.1 MT-ND4 OPA1 TMEM126A
16 ausems wittebol-post hennekam syndrome 9.9 OPA1 TMEM126A
17 neuritis 9.9
18 ciliary dyskinesia, primary, 9, with or without situs inversus 9.8 ABCA4 RDH5
19 macular holes 9.8
20 headache 9.8
21 hypopigmentation of eyelid 9.8 MT-ND4 SNCA
22 systemic lupus erythematosus 9.7
23 stargardt disease 9.7
24 cataract 9.7
25 amblyopia 9.7
26 open-angle glaucoma 9.7
27 choroiditis 9.7
28 uveitis 9.7
29 cerebritis 9.7
30 strabismus 9.7
31 adenoma 9.7
32 lupus erythematosus 9.7
33 anterior uveitis 9.7
34 aneurysm 9.7
35 pituitary tumors 9.7
36 cole-carpenter syndrome 9.6 DLG3 SNCA
37 charcot-marie-tooth disease, dominant intermediate f 9.6 MT-ND4 SNCA
38 hepatitis c virus 9.6
39 pituitary adenoma 9.6
40 hepatitis 9.6
41 retinal vein occlusion 9.6
42 sinusitis 9.6
43 cytomegalovirus retinitis 9.6
44 migraine with aura 9.6
45 neuroretinitis 9.6
46 endocarditis 9.6
47 astigmatism 9.6
48 myopia 9.6
49 optic neuritis 9.6
50 hepatitis c 9.6

Graphical network of the top 20 diseases related to Scotoma:



Diseases related to Scotoma

Symptoms & Phenotypes for Scotoma

Drugs & Therapeutics for Scotoma

Drugs for Scotoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 3,Phase 1,Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3
3 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2
4 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2
5 Omega 3 Fatty Acid Nutraceutical Phase 3
6
Idebenone Approved, Investigational Phase 2 58186-27-9
7
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
8 Antioxidants Phase 2
9 Micronutrients Phase 2
10 Protective Agents Phase 2
11 Trace Elements Phase 2
12 Ubiquinone Phase 2
13
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
14 Anti-Infective Agents
15 Antiparasitic Agents
16 Antiprotozoal Agents
17 Diminazene aceturate
18 Liver Extracts
19 Fibrinolytic Agents
20 Plasminogen
21 Tissue Plasminogen Activator
22
Lutein Nutraceutical 127-40-2 6433159 5368396

Interventional clinical trials:

(show all 34)

id Name Status NCT ID Phase Drugs
1 Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy Unknown status NCT01255774 Phase 3 ranibizumab
2 Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions Unknown status NCT01418820 Phase 2, Phase 3
3 Bevacizumab Versus Ranibizumab for Diabetic Retinopathy Completed NCT00545870 Phase 3 bevacizumab;Ranibizumab
4 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3 Ocriplasmin;Sham injection
5 Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD). Terminated NCT00987129 Phase 3
6 Scotoma Reduction in AMD Patients Treated With Ranibizumab Completed NCT00467935 Phase 1, Phase 2 intravitreal injection Lucentis (ranibizumab)
7 Evaluation of Eye Movement Tracking Systems for Visual Rehabilitation Completed NCT00013429 Phase 2
8 Low Vision Study Comparing EV Training vs. CCTV for AMD Rehabilitation Completed NCT00971464 Phase 2
9 Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial) Completed NCT00504400 Phase 2 Intravitreal injection ranibizumab
10 Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy Completed NCT00747487 Phase 2 Idebenone;Placebo
11 Visuomotor Rehabilitation Training Completed NCT01691027 Early Phase 1
12 A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph Completed NCT01843582
13 The Use of Transcranial Direct Current Stimulation (TDCS) to Enhance the Rehabilitative Effect of Vision Restoration Therapy Completed NCT00921427 Early Phase 1
14 Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration Completed NCT00329277
15 Sparing of the Fovea in Geographic Atrophy Progression Completed NCT02332343
16 Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration Completed NCT00879671
17 A Clinical Study of Fundus Findings in Toxaemia of Pregnancy Completed NCT03076619
18 Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery Completed NCT00419185
19 Age-related Normative Values for the Octopus 900 Perimeter Completed NCT01518686
20 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
21 Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV) Recruiting NCT02829606
22 Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema Recruiting NCT02457884
23 Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery Recruiting NCT02894424
24 Telescope Exchange Study Recruiting NCT03011554
25 Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina Recruiting NCT02088151
26 Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial Fibrillation Recruiting NCT02424110
27 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
28 Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients Active, not recruiting NCT00902109
29 Comparison of Visual Fields: Humphrey Field Analyzer (HFA) SITA Strategy, SCOPE (GATE Strategy) and Humphrey MATRIX Perimeter Active, not recruiting NCT01068938
30 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730
31 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504
32 Treatment Trial for Acute Central Serous Chorioretinopathy Enrolling by invitation NCT02784665
33 Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration Enrolling by invitation NCT02747368
34 Surgery, Tissue Plasminogen Activator, Antiangiogenic Agents and Age Related Macular Degeneration Complications Not yet recruiting NCT02557451

Search NIH Clinical Center for Scotoma

Genetic Tests for Scotoma

Genetic tests related to Scotoma:

id Genetic test Affiliating Genes
1 Scotoma 29

Anatomical Context for Scotoma

MalaCards organs/tissues related to Scotoma:

39
Eye, Testes, Retina, Endothelial, Liver, Cortex, Pituitary

Publications for Scotoma

Articles related to Scotoma:

(show top 50) (show all 225)
id Title Authors Year
1
Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma. ( 28821922 )
2017
2
Retinal slippage fold causing a matching contralateral scotoma. ( 28395868 )
2017
3
Acquired unilateral scotoma. ( 28684101 )
2017
4
Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma. ( 28614218 )
2017
5
Temporal crescent syndrome vs arcuate scotoma. ( 28318737 )
2017
6
Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation. ( 28282064 )
2017
7
TEMPORAL THINNING IN SICKLE CELL RETINOPATHY IS ASSOCIATED WITH DIMINISHED PERFUSION ON OCTA AND DENSE SCOTOMA ON MICROPERIMETERY. ( 28644178 )
2017
8
SCOTOMA CHARACTERISTICS IN MACULAR TELANGIECTASIA TYPE 2: MacTel Project Report No. 7-The MacTel Research Group. ( 28609329 )
2017
9
Ocular and Systemic Risk Factors of Different Morphologies of Scotoma in Patients with Normal-Tension Glaucoma. ( 28815087 )
2017
10
The Effects of Nocturnal Dip and Blood Pressure Variability on Paracentral Scotoma in Early Open-Angle Glaucoma. ( 27128963 )
2016
11
Optic Disk Pit with Sudden Central Visual Field Scotoma. ( 27872777 )
2016
12
Characteristics of the preferred retinal loci of better and worse seeing eyes of patients with a central scotoma. ( 27769327 )
2016
13
Scotoma Visibility and Reading Rate with Bilateral Central Scotomas. ( 28030516 )
2016
14
Structure-Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma. ( 26848881 )
2016
15
MAPPING THE DENSE SCOTOMA AND ITS ENLARGEMENT IN STARGARDT DISEASE. ( 26909568 )
2016
16
Progressing Scintillating Scotoma Captured on Automated Visual Field Testing. ( 26854039 )
2016
17
Assessing the GOANNA Visual Field Algorithm Using Artificial Scotoma Generation on Human Observers. ( 27622080 )
2016
18
Comparison of retinal vessel diameter between open-angle glaucoma patients with initial parafoveal scotoma and peripheral nasal step. ( 27916714 )
2016
19
Scotoma analysis of 10-2 visual field testing with a red target in screening for hydroxychloroquine retinopathy. ( 26316692 )
2015
20
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy. ( 26060390 )
2015
21
Optimal point of fixation to faces for vision with a simulated central scotoma. ( 26326621 )
2015
22
fMRI of the rod scotoma elucidates cortical rod pathways and implications for lesion measurements. ( 25848028 )
2015
23
Microperimetry biofeedback training in a patient with bilateral myopic macular degeneration with central scotoma. ( 26265646 )
2015
24
Random word recognition chart helps scotoma assessment in low vision. ( 25946100 )
2015
25
Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. ( 26476213 )
2015
26
Stop before you saccade: Looking into an artificial peripheral scotoma. ( 26067525 )
2015
27
Comparison of Risk Factors for Initial Central Scotoma versus Initial Peripheral Scotoma in Normal-tension Glaucoma. ( 25829826 )
2015
28
Long-lasting, dense scotoma under light-adapted conditions in patient with multiple evanescent white dot syndrome. ( 26678272 )
2015
29
Size of the foveal blue scotoma related to the shape of the foveal pit but not to macular pigment. ( 25449158 )
2015
30
Comment on "Central scotoma and 'muddled thinking' as migraine aura" by Daroff. ( 24045572 )
2014
31
Adaptation to a simulated central scotoma during visual search training. ( 24456805 )
2014
32
Paracentral scotoma in glaucoma detected by 10-2 but not by 24-2 perimetry. ( 24442888 )
2014
33
Anatomical attributes of the optic nerve head in eyes with parafoveal scotoma in normal tension glaucoma. ( 24595065 )
2014
34
Xanthic scotoma. ( 25256032 )
2014
35
Central scotoma and 'muddled thinking' as migraine aura. ( 24045570 )
2014
36
Reading with peripheral vision: a comparison of reading dynamic scrolling and static text with a simulated central scotoma. ( 24680772 )
2014
37
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma: Reply. ( 25313790 )
2014
38
Confusion Between Bitemporal Hemianopia and Cecocentral Scotoma. ( 25313789 )
2014
39
The effect of strabismus on object detection in the ring scotoma of a monocular bioptic telescope. ( 23639041 )
2013
40
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. ( 23481153 )
2013
41
Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. ( 23620092 )
2013
42
Fixation stability and scotoma mapping for patients with low vision. ( 23334309 )
2013
43
Arcuate scotoma associated with traction at the optic disc. ( 23449516 )
2013
44
Initial central scotomas vs peripheral scotomas in normal-tension glaucoma: clinical characteristics and progression rates. ( 24357841 )
2013
45
Parafoveal scotoma progression in glaucoma: humphrey 10-2 versus 24-2 visual field analysis. ( 23697959 )
2013
46
Rehabilitative approach in patients with ring scotoma. ( 24093190 )
2013
47
Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma. ( 23972895 )
2013
48
A behavioral task for the validation of a gaze-contingent simulated scotoma. ( 23526257 )
2013
49
Scotomas in molecular virology and epidemiology of hepatitis C virus. ( 24307785 )
2013
50
Characteristics of optic disc morphology in glaucoma patients with parafoveal scotoma compared to peripheral scotoma. ( 22714895 )
2012

Variations for Scotoma

Expression for Scotoma

Search GEO for disease gene expression data for Scotoma.

Pathways for Scotoma

Pathways related to Scotoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.36 ABCA4 RDH5

GO Terms for Scotoma

Cellular components related to Scotoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I GO:0005747 8.62 MT-ND4 SNCA

Biological processes related to Scotoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.46 ABCA4 OPA1 RDH5 TRPM1
2 retinoid metabolic process GO:0001523 9.26 ABCA4 RDH5
3 aging GO:0007568 9.13 MT-ND4 OPA1 SNCA
4 visual perception GO:0007601 8.92 ABCA4 OPA1 RDH5 TRPM1

Sources for Scotoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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