Aliases & Classifications for Scrapie

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT
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Aliases & Descriptions for Scrapie:

Name: Scrapie 10 47 12 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:5434
SNOMED-CT59 35103004
MeSH36 D012608

Summaries for Scrapie

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Wikipedia:68 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to alzheimer disease and encephalopathy. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways are Glypican 1 network and A-beta Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and lymph node, and related mouse phenotypes are reproductive system and normal.

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer disease29.3ADAM10, APP, CHAT, GFAP, MAP2, MAPT
2encephalopathy10.9
3prion disease10.6
4creutzfeldt-jakob disease10.6
5chronic wasting disease10.6
6neuronitis10.6
7kuru10.3
8familial mediterranean fever type 110.3PRND, PRNP
9harp syndrome10.3PRND, PRNP
10neuroblastoma10.3
11prion disease with protracted course10.3APP, PRNP
12cerebral palsy10.2APP, GFAP
13intravascular angioleiomyoma10.2MAPT, PRNP
14stress polycythemia10.2APP, SPRN
15pharyngitis10.2
16tonsillitis10.2
17encephalitis10.2
18headache10.2CHAT, GFAP
19retinal degeneration autosomal recessive clumped pigment type10.2APP, CHAT
20chiari malformation type 110.2GFAP, MAP2
21central nervous system sarcoma10.1GFAP, MAP2
22urethritis10.1GFAP, MAP2
23progesterone-receptor positive breast cancer10.1GFAP, MAP2
24kernicterus10.1GFAP, MAPT
25selective igg deficiency disease10.1GFAP, MAP2
26rete ovarii cystadenofibroma10.1GFAP, MAP2
27brain meningioma10.1GFAP, MAP2
28atrioventricular septal defect 510.1APP, MAPT
29central nervous system fibrosarcoma10.1GFAP, MAP2
30lipoprotein glomerulopathy10.1APP, MAPT
313mc syndrome10.1MAPT, PRNP
32macular degeneration, age-related, 1110.1APP, MAPT, PRNP
33dementia, lewy body10.1APP, MAPT, PRNP
34birdshot chorioretinopathy10.0APP, GFAP, MAPT
35apocrine adenocarcinoma10.0MAPT, PRNP
36optic nerve neoplasm10.0GFAP, MAP2
37demyelinating disease10.0APP, MAPT, PRNP
38neuroaxonal dystrophy10.0
39louping ill10.0
40cerebritis10.0
41mastitis10.0
42mouth disease10.0
43peritonitis10.0
44retinitis10.0
45neurologic diseases10.0
46genetic prion diseases10.0
47endotheliitis10.0
48teeth hard tissue disease10.0ADAM10, APP, MAPT
49supranuclear palsy, progressive atypical10.0APP, CHAT, MAPT
50ischemic bone disease10.0APP, GFAP, MAP2

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at HomeRecruitingNCT02346305

Search NIH Clinical Center for Scrapie


Cochrane evidence based reviews: Scrapie

Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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MalaCards organs/tissues related to Scrapie:

33
Brain, Testes, Lymph node, Spleen, T cells, Placenta, B cells

Animal Models for Scrapie or affiliated genes

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MGI Mouse Phenotypes related to Scrapie:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9APP, CHAT, MAP2, MT2A, PRND, PRNP
2MP:00028737.8ADAM10, APP, CHAT, GFAP, MAPT, MT2A
3MP:00053866.7APP, CHAT, GFAP, MAP2, MAPT, MT2A
4MP:00036316.1ADAM10, APP, CHAT, GFAP, MAP2, MAPT
5MP:00107685.7ADAM10, APP, CHAT, GFAP, MAP2, MAPT
6MP:00053785.6ADAM10, APP, CHAT, GFAP, MAP2, MAPT

Publications for Scrapie

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Articles related to Scrapie:

(show top 50)    (show all 652)
idTitleAuthorsYear
1
Correction: Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells. (25821952)
2015
2
EFSA assesses the impact of scrapie eradication policies. (25125401)
2014
3
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
4
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
5
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
6
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
7
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
8
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
9
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
10
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
11
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
12
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. (20085753)
2010
13
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
14
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
15
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
16
Scrapie genetics before the discovery of prions. (19707236)
2010
17
Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. (19751582)
2009
18
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
19
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
20
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. (19606066)
2009
21
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
22
Distinct spatial activation of intrinsic and extrinsic apoptosis pathways in natural scrapie: association with prion-related lesions. (19401142)
2009
23
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
24
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
25
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
26
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. (18667494)
2008
27
Detection of prion infectivity in fat tissues of scrapie-infected mice. (19057664)
2008
28
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
29
Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility. (17361441)
2007
30
Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. (19164931)
2007
31
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
32
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
33
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
34
An evaluation of scrapie surveillance in the United States. (17482695)
2007
35
Effectiveness of capillary electrophoresis fluoroimmunoassay of blood PrpSc for evaluation of scrapie pathogenesis in sheep. (17823402)
2007
36
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
37
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
38
Infectivity of scrapie prion protein (PrPSc) following in vitro digestion with bovine gastrointestinal microbiota. (17542960)
2007
39
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
40
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
41
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
42
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)
2006
43
Scrapie and chronic wasting disease. (12733429)
2003
44
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
45
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
46
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
47
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
48
Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. (8372644)
1993
49
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
50
Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)
1990

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

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GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear peripheryGO:003439910.0MAP2, MAPT
2microtubule associated complexGO:00058759.9MAP2, MAPT
3dendritic shaftGO:00431989.9APP, MAP2
4anchored component of membraneGO:00312259.7PRND, PRNP, SPRN
5cell bodyGO:00442979.5GFAP, MAP2, MAPT
6postsynaptic densityGO:00140698.8ADAM10, MAP2, MAPT
7cell surfaceGO:00099868.6ADAM10, APP, PRNP, TF

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:00080889.7APP, MAPT
2dendrite developmentGO:00163589.5APP, MAP2
3cellular copper ion homeostasisGO:00068789.0APP, MT2A, PRND, PRNP
4axonogenesisGO:00074098.7APP, MAP2, MAPT

Molecular functions related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tubulin bindingGO:00156319.2MAP2, MAPT, PRNP
2microtubule bindingGO:00080179.2MAP2, MAPT, PRNP

Sources for Scrapie

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet