MCID: SCR011
MIFTS: 38

Scrapie malady

Categories: Neuronal diseases

Aliases & Classifications for Scrapie

Aliases & Descriptions for Scrapie:

Name: Scrapie 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 42 D012608
SNOMED-CT 64 35103004
UMLS 69 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to creutzfeldt-jakob disease and encephalopathy. An important gene associated with Scrapie is SCRG1 (Stimulator Of Chondrogenesis 1), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. The drugs Ethanol and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 creutzfeldt-jakob disease 11.2
2 encephalopathy 10.5
3 prion disease 10.3
4 adult choroid plexus cancer 10.2 PRNP SPRN
5 deafness, autosomal recessive 101 10.2 GFAP PRNP
6 chronic wasting disease 10.2
7 neuronitis 10.2
8 alagille syndrome 10.2 MSMB PRND PRNP
9 homocystinuria caused by cystathionine beta-synthase deficiency 10.2 APOE PRNP
10 huntington disease-like 1 10.2 APP MSMB PRNP
11 charcot-marie-tooth disease 10.2 APP GFAP PRNP
12 amelogenesis imperfecta, type iia3 10.1 ADAM10 APP
13 children's interstitial lung disease 10.1 GFAP MAP2
14 pars planitis 10.1 APOE RPSA
15 encephalitozoonosis 10.1 APOE APP
16 vulvar benign neoplasm 10.1 GFAP MAP2
17 adenofibroma 10.1 GFAP MAP2
18 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 10.1 APOE APP PRNP
19 hemorrhagic proctocolitis 10.1 GFAP MAP2
20 contagious pustular dermatitis 10.1 APOE APP PRNP
21 coenzyme q10 deficiency, primary, 1 10.1 APOE APP PRNP
22 bone dysplasia azouz type 10.1 APOE APP GFAP
23 alzheimer disease 19, late onset 10.1 APOE CLU
24 hard palate cancer 10.0 APOE APP PRNP
25 ichthyosis lamellar 2 10.0 APOE APP GFAP
26 ovarian mucinous adenocarcinoma 10.0 GFAP MAP2 PRNP
27 bronchiolitis obliterans 10.0 GFAP MAP2
28 fancf-related fanconi anemia 10.0 APOE MSMB PRND PRNP
29 eumycotic mycetoma 10.0 APOE APP PRNP
30 brain stem astrocytic neoplasm 10.0 GFAP MAP2
31 substance-induced psychosis 10.0 APOE APP GFAP PRNP
32 epithelioid type angiomyolipoma 10.0 APOE APP GFAP PRNP
33 kuru 9.9
34 calcific tendinitis 9.9 GFAP MAP2
35 xfe progeroid syndrome 9.9 CLU TF
36 neuroblastoma 9.9
37 long qt syndrome 5 9.8 APP GFAP MAP2 PRNP
38 alzheimer disease 9.8
39 tonsillitis 9.8
40 pharyngitis 9.8
41 encephalitis 9.8
42 prion disease with protracted course 9.7 APOE MSMB PRND PRNP RPSA SPRN
43 louping ill 9.6
44 mastitis 9.6
45 neuroaxonal dystrophy 9.6
46 cerebritis 9.6
47 retinitis 9.6
48 mouth disease 9.6
49 peritonitis 9.6
50 genetic prion diseases 9.6

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.86 APOE APP CLU GFAP MAP2 PRND
2 growth/size/body region MP:0005378 9.81 ADAM10 APOE APP GFAP MAP2 PRNP
3 immune system MP:0005387 9.56 PRND PRNP ADAM10 APOE APP CLU
4 nervous system MP:0003631 9.28 ADAM10 APOE APP CLU GFAP MAP2

Drugs & Therapeutics for Scrapie

Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 3 64-17-5 702
2
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
3
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
5 Folic Acid Antagonists Phase 2
6 Nucleic Acid Synthesis Inhibitors Phase 2
7 Dermatologic Agents Phase 2
8 Vitamin B Complex Phase 2
9 Immunosuppressive Agents Phase 2
10 Antimetabolites Phase 2
11 Antimetabolites, Antineoplastic Phase 2
12 Antirheumatic Agents Phase 2
13 Folate Nutraceutical Phase 2
14 Vitamin B9 Nutraceutical Phase 2
15 Anesthetics
16 Central Nervous System Depressants

Interventional clinical trials:


id Name Status NCT ID Phase
1 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
2 Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid Arthritis Recruiting NCT02638948 Phase 2
3 Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home Recruiting NCT02346305
4 Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Recruiting NCT02507505

Search NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

39
Brain, Testes, Spleen, Lymph Node, Retina, T Cells, Placenta

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 704)
id Title Authors Year
1
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. ( 27936597 )
2017
2
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. ( 28063003 )
2017
3
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. ( 27751198 )
2017
4
Identification of the first case of atypical scrapie in Japan. ( 27616556 )
2016
5
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. ( 27317933 )
2016
6
Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health. ( 27928518 )
2016
7
Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia. ( 26807844 )
2016
8
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. ( 27921253 )
2016
9
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. ( 27211330 )
2016
10
Controlling scrapie and bovine spongiform encephalopathy in goats. ( 26868240 )
2016
11
Altered trafficking of abnormal prion protein in atypical scrapie: Prion protein accumulation in oligodendroglial inner mesaxons. ( 26750308 )
2016
12
Prion protein scrapie and the normal cellular prion protein. ( 26645475 )
2016
13
Temporal Resolution of Misfolded Prion Protein Transport, Accumulation, Glial Activation, and Neuronal Death in the Retinas of Mice Inoculated with Scrapie. ( 27521336 )
2016
14
Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. ( 26755614 )
2016
15
MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15. ( 27826142 )
2016
16
Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs. ( 27417309 )
2016
17
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells. ( 27537339 )
2016
18
Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats. ( 27005313 )
2016
19
Evidence of scrapie transmission to sheep via goat milk. ( 27640200 )
2016
20
Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. ( 27991723 )
2016
21
Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. ( 27033930 )
2016
22
Isolation of a Defective Prion Mutant from Natural Scrapie. ( 27880822 )
2016
23
Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains. ( 26936223 )
2016
24
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. ( 26847623 )
2016
25
Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease. ( 27463540 )
2016
26
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie. ( 27385410 )
2016
27
Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic. ( 27215403 )
2016
28
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions. ( 27259989 )
2016
29
Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion. ( 26653410 )
2016
30
Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice. ( 27221113 )
2016
31
Goat K222-PrP(C) polymorphic variant does not provide resistance to atypical scrapie in transgenic mice. ( 27659200 )
2016
32
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. ( 26655166 )
2016
33
Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain. ( 26976340 )
2016
34
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models. ( 26887380 )
2016
35
Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. ( 27021907 )
2016
36
CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection. ( 26773845 )
2016
37
Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals. ( 27590859 )
2016
38
Transmission of atypical scrapie to homozygous ARQ sheep. ( 27320968 )
2016
39
Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease. ( 27109462 )
2016
40
In this issue - December 2016: Chemical immobilisation of free-range cattlea88A^a88Dairy cow progesterone assaya88A^a88Atypical scrapie in sheepa88A^a88Antibiotic resistance in healthy dogsa88A^a88Contrast CT in dermoid sinusesa88A^ Pneumorrhachis in a doga88A^a88Dorsal perineal artery for axial pattern flap surgery in a cata88A^a88Inducing emesis in dogs. ( 27891596 )
2016
41
Atypical scrapie in Australia. ( 27807855 )
2016
42
A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. ( 27216989 )
2016
43
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. ( 27393736 )
2016
44
Evaluation of efficacy of prion reduction filters using blood from an endogenously infected 263K scrapie hamster model. ( 26033029 )
2015
45
Mechanism of Scrapie Prion Precipitation with Phosphotungstate Anions. ( 25695325 )
2015
46
Synthetic Scrapie Infectivity: Interaction between Recombinant PrP and Scrapie Brain-Derived RNA. ( 25585171 )
2015
47
Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice. ( 26396245 )
2015
48
Correction: A Bovine Cell Line That Can Be Infected by Natural Sheep Scrapie Prions. ( 25806533 )
2015
49
PrP genotype frequencies and risk evaluation for scrapie in dairy sheep breeds from southern Italy. ( 26549664 )
2015
50
Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time. ( 25928902 )
2015

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 APOE APP CLU GFAP MAP2 PRNP
2 10.99 ADAM10 APOE APP
3 10.99 ADAM10 APP MT2A PRNP
4 10.97 APOE MAP2
5 10.91 APOE APP
6 10.74 ADAM10 APP
7 10.67 APP PRNP

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.8 ADAM10 APOE APP CLU PRNP SCRG1
2 extracellular region GO:0005576 9.76 APOE APP CLU MSMB PRND SCRG1
3 postsynaptic density GO:0014069 9.61 ADAM10 MAP2 PRNP
4 blood microparticle GO:0072562 9.58 APOE CLU TF
5 endoplasmic reticulum lumen GO:0005788 9.56 ADAM10 APOE APP TF
6 anchored component of membrane GO:0031225 9.54 PRND PRNP SPRN
7 dendritic shaft GO:0043198 9.46 APP MAP2
8 cell surface GO:0009986 9.35 ADAM10 APP CLU PRNP TF
9 extracellular space GO:0005615 9.17 ADAM10 APOE APP CLU MSMB SCRG1

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.71 ADAM10 APOE APP TF
2 response to oxidative stress GO:0006979 9.67 APOE APP PRNP
3 cellular protein metabolic process GO:0044267 9.67 ADAM10 APOE APP TF
4 platelet degranulation GO:0002576 9.63 APP CLU TF
5 positive regulation of neuron death GO:1901216 9.52 CLU PRNP
6 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 CLU TF
7 nitric oxide mediated signal transduction GO:0007263 9.48 APOE MT2A
8 reverse cholesterol transport GO:0043691 9.43 APOE CLU
9 negative regulation of beta-amyloid formation GO:1902430 9.32 APOE CLU
10 protein import GO:0017038 9.26 APOE CLU
11 negative regulation of long-term synaptic potentiation GO:1900272 9.16 APOE PRNP
12 regulation of beta-amyloid clearance GO:1900221 8.96 APOE CLU
13 cellular copper ion homeostasis GO:0006878 8.92 APP MT2A PRND PRNP

Molecular functions related to Scrapie according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle receptor binding GO:0050750 8.96 APOE CLU
2 beta-amyloid binding GO:0001540 8.8 APOE CLU PRNP

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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