MCID: SCR011
MIFTS: 39

Scrapie malady

Categories: Neuronal diseases, Blood diseases

Aliases & Classifications for Scrapie

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Aliases & Descriptions for Scrapie:

Name: Scrapie 11 49 38 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:5434
SNOMED-CT61 35103004
MeSH38 D012608

Summaries for Scrapie

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Wikipedia:70 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to creutzfeldt-jakob disease and familial mediterranean fever type 2. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways are Glypican 1 network and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and spleen, and related mouse phenotypes are immune system and behavior/neurological.

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1creutzfeldt-jakob disease11.2
2familial mediterranean fever type 210.6PRND, PRNP
3encephalopathy10.5
4choroid plexus cancer10.5PRNP, SPRN
5diabetes insipidus, neurohypophyseal10.5MSMB, PRNP
6alagille syndrome10.4MSMB, PRND, PRNP
7glucose transporter type 1 deficiency syndrome10.4APOE, PRNP
8huntington disease-like 110.3APP, MSMB, PRNP
9hemiplegia alterans10.3APOE, GFAP
10prion disease10.3
11intravascular angioleiomyoma10.3APOE, APP
12chiari malformation type 410.2GFAP, MAP2
13chronic wasting disease10.2
14neuronitis10.2
15respiratory syncytial virus infectious disease10.2APOE, RPSA
16alzheimer disease 19, late onset10.2APOE, CLU
17intracystic papillary adenoma10.2GFAP, MAP2
18congenital hypogammaglobulinemia10.2GFAP, MAP2
19retinal arteries, tortuosity of10.2APOE, APP
20epidermolysis bullosa with pyloric atresia10.1APOE, APP
21ulcerative colitis10.1APOE, GFAP
22large intestine lipoma10.1GFAP, MAP2
23microsporidiosis10.1APOE, PRNP
24polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.1APOE, APP, PRNP
25rheumatic disease10.1APOE, APP
26chronic gonorrhea of cervix10.0APP, SPRN
27ovarian mucinous cystadenocarcinoma10.0GFAP, MAP2, PRNP
28tinea unguium10.0APOE, APP, PRNP
29brain meningioma10.0APOE, GFAP
30anti-p200 pemphigoid10.0APOE, MAP2
31kuru9.9
32gastric small cell carcinoma9.9GFAP, TF
33mixed epithelial stromal tumour9.9GFAP, MAP2
34xfe progeroid syndrome9.9CLU, TF
35neuroblastoma9.9
36angiomyolipoma9.8APOE, APP, GFAP, PRNP
37chronic intestinal vascular insufficiency9.8APOE, APP, GFAP, PRNP
38alzheimer disease9.8
39tonsillitis9.8
40pharyngitis9.8
41encephalitis9.8
42long qt syndrome 59.7APP, GFAP, MAP2, PRNP
43adenomyoma of uterine corpus9.7GFAP, MAP2
44louping ill9.6
45mastitis9.6
46neuroaxonal dystrophy9.6
47cerebritis9.6
48retinitis9.6
49mouth disease9.6
50peritonitis9.6

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EthanolapprovedPhase 3204364-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
2
MethotrexateapprovedPhase 215181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
3
Folic Acidapproved, nutraceutical, vet_approvedPhase 2427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
4Immunosuppressive AgentsPhase 212770
5Nucleic Acid Synthesis InhibitorsPhase 24855
6Vitamin B ComplexPhase 24229
7Folic Acid AntagonistsPhase 22200
8AntimetabolitesPhase 211774
9Antirheumatic AgentsPhase 210627
10Antimetabolites, AntineoplasticPhase 27171
11Dermatologic AgentsPhase 25674
12Vitamin B9NutraceuticalPhase 24279
13Folinic AcidNutraceuticalPhase 23150
14FolateNutraceuticalPhase 24279
15Central Nervous System Depressants12806
16Anesthetics9001

Interventional clinical trials:

idNameStatusNCT IDPhase
1Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep ApneaRecruitingNCT02989181Phase 3
2Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid ArthritisRecruitingNCT02638948Phase 2
3Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at HomeRecruitingNCT02346305
4Regional Versus General Anesthesia for Promoting Independence After Hip FractureRecruitingNCT02507505

Search NIH Clinical Center for Scrapie


Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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MalaCards organs/tissues related to Scrapie:

35
Brain, Testes, Spleen, Lymph node, Retina, Placenta, T cells

Animal Models for Scrapie or affiliated genes

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MGI Mouse Phenotypes related to Scrapie:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2ADAM10, APOE, APP, CLU, GFAP, MSMB
2MP:00053868.1APOE, APP, CLU, GFAP, MAP2, PRND
3MP:00053787.1ADAM10, APOE, APP, GFAP, MAP2, PRNP
4MP:00036316.8ADAM10, APOE, APP, CLU, GFAP, MAP2

Publications for Scrapie

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Articles related to Scrapie:

(show top 50)    (show all 704)
idTitleAuthorsYear
1
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. (26655166)
2016
2
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. (27211330)
2016
3
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. (27317933)
2016
4
Atypical scrapie in Australia. (27807855)
2016
5
Prion protein scrapie and the normal cellular prion protein. (26645475)
2016
6
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie. (27385410)
2016
7
Transmission of atypical scrapie to homozygous ARQ sheep. (27320968)
2016
8
Correction: Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells. (25821952)
2015
9
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
10
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
11
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
12
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
13
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
14
Direct evidence of generation and accumulation of I^-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for I^-form prion protein. (22356913)
2012
15
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
16
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
17
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
18
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
19
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
20
Sheep with scrapie and mastitis transmit infectious prions through the milk. (21084475)
2011
21
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
22
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
23
Scrapie genetics before the discovery of prions. (19707236)
2010
24
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
25
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
26
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
27
Olfactory system involvement in natural scrapie disease. (19158242)
2009
28
Scrapie pathogenesis: the role of complement C1q in scrapie agent uptake by conventional dendritic cells. (19155476)
2009
29
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
30
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
31
In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie. (19008409)
2008
32
Observing fibrillar assemblies on scrapie-infected cells. (18175144)
2008
33
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
34
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
35
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
36
An evaluation of scrapie surveillance in the United States. (17482695)
2007
37
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
38
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
39
Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters. (17181988)
2007
40
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
41
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
42
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
43
Scrapie and chronic wasting disease. (12733429)
2003
44
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
45
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
46
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
47
Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform. (8643624)
1996
48
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
49
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
50
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

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Pathways related to Scrapie according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6APP, PRNP
29.4ADAM10, APP
39.3APOE, APP
48.9ADAM10, APOE, APP
57.9APOE, APP, CLU, GFAP, MAP2, PRNP

GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1astrocyte projectionGO:009744910.3APP, GFAP
2anchored component of membraneGO:003122510.1PRND, PRNP, SPRN
3blood microparticleGO:00725629.0APOE, CLU, TF
4Golgi apparatusGO:00057948.5ADAM10, APOE, APP, CLU, PRNP, SCRG1
5cell surfaceGO:00099868.3ADAM10, APP, CLU, PRNP, TF
6extracellular spaceGO:00056157.9APOE, APP, CLU, MSMB, SCRG1, TF
7membraneGO:00160207.6ADAM10, APOE, APP, GFAP, PRNP, RPSA
8cytoplasmGO:00057376.3ADAM10, APOE, APP, CLU, GFAP, MAP2

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:003110210.0APOE, GFAP
2negative regulation of beta-amyloid formationGO:19024309.9APOE, CLU
3protein importGO:00170389.8APOE, CLU
4reverse cholesterol transportGO:00436919.8APOE, CLU
5regulation of beta-amyloid clearanceGO:19002219.8APOE, CLU
6cellular copper ion homeostasisGO:00068789.3APP, MT2A, PRND, PRNP
7response to oxidative stressGO:00069799.1APOE, APP, PRNP
8platelet degranulationGO:00025768.7APP, CLU, TF

Sources for Scrapie

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet