MCID: SCR011
MIFTS: 39

Scrapie malady

Summaries for Scrapie

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63Wikipedia, 32MalaCards
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Wikipedia:63 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards: Scrapie is related to bovine spongiform encephalopathy and prion disease. An important gene associated with Scrapie is PRNP (prion protein). The compounds inulin and kainate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node.

Aliases & Classifications for Scrapie

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

scrapie 8 10 44 60


External Ids:

Disease Ontology8 DOID:5434
SNOMED-CT56 35103004
MeSH34 D012608

Related Diseases for Scrapie

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17GeneCards, 18GeneDecks
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Diseases related to Scrapie via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1bovine spongiform encephalopathy31.1PRNP, PRND
2prion disease31.0PVALB
3neuroblastoma30.1PRNP
4alzheimer's disease29.8CST3, BLVRB, CLU, PRNP, PRND, PVALB
5chronic wasting disease10.5
6neuronitis10.4
7brain disease10.4
8tonsillitis10.1
9encephalitis10.1
10myositis10.0MAPT, PRNP
11bladder carcinoma10.0CLU
12progressive supranuclear palsy10.0PVALB, PRNP, MAPT
13familial creutzfeldt-jakob disease10.0PRND, PRNP, MSMB
14vascular dementia10.0PRNP, CST3, MAPT
15amyloid tumor10.0MAPT, CST3, PRNP
16cerebral amyloid angiopathy10.0CST3, MAPT, PRNP
17multiple sclerosis10.0CLU, CST3, BLVRB
18fibrosarcoma10.0CLU, CST3
19amyloidosis10.0PRNP, MAPT, CLU, CST3
20lewy body dementia10.0PRNP, MAPT
21epilepsy syndrome10.0CLU, BLVRB, PRNP, PVALB
22dementia10.0PVALB, CST3, PRNP, CLU, MAPT
23cadasil10.0CST3, MAPT, PVALB, PRNP
24parkinson's disease10.0PVALB, BLVRB, MAPT, PRNP
25amyotrophic lateral sclerosis10.0CST3, BLVRB, PVALB, PRNP, MAPT
26creutzfeldt-jakob syndrome10.0MSMB, CST3, PVALB, PRNP, PRND, MAPT
27huntington's disease10.0MAPT, BLVRB, PRNP
28multiple system atrophy10.0PRNP, PVALB, MAPT
29hemorrhage, intracerebral10.0PRNP, CST3
30cerebritis9.9
31pharyngitis9.9
32neuroaxonal dystrophy9.9
33louping ill9.9
34blood protein disease9.9
35encephalomyelitis9.9
36mastitis9.9
37mouth disease9.9
38movement disease9.9
39optic nerve disease9.9
40peritonitis9.9
41retinitis9.9
42neurologic diseases9.9
43genetic prion diseases9.9
44variant creutzfeldt-jakob disease9.9

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Clinical Features for Scrapie

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Drugs & Therapeutics for Scrapie

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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32MalaCards
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MalaCards organs/tissues related to Scrapie:

32
Brain, Testes, Lymph node, Retina, B cells, T cells, Spleen, Medulla oblongata, Tonsil, Placenta, Skin, Kidney, Bone, Cortex, Cerebellum, Adrenal gland, Salivary gland, Liver, Pituitary, Endothelial, Eye

Animal Models for Scrapie or affiliated genes

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Publications for Scrapie

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50PubMed
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Articles related to Scrapie:

(show top 50)    (show all 599)
idTitleAuthorsYear
1
Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes. (24401607)
2014
2
Influence of Polymorphisms in the Prion Protein Gene on the Pathogenesis and Neuropathological Phenotype of Sheep Scrapie after Oral Infection. (24342584)
2013
3
Direct evidence of generation and accumulation of I^-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for I^-form prion protein. (22356913)
2012
4
Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein. (22495232)
2012
5
Acetone precipitation of the scrapie agent results in successful recovery of PrP(Sc) but decreased infectivity. (22519670)
2012
6
Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice. (22522067)
2012
7
Genotyping and surveillance for scrapie in Finnish sheep. (22831168)
2012
8
Ultrasensitive detection of scrapie prion protein derived from ARQ and AHQ homozygote sheep by interspecies in vitro amplification. (22548476)
2012
9
Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222. (22516690)
2012
10
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
11
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
12
Blocking of FcR suppresses the intestinal invasion of scrapie agents. (21437246)
2011
13
White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation. (21988781)
2011
14
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
15
Disease-associated prion protein in the dental tissue of mice infected with scrapie. (20202648)
2010
16
PrP(Sc) is associated with B cells in the blood of scrapie-infected sheep. (20646730)
2010
17
Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak. (20031179)
2010
18
Atypical scrapie in sheep from a UK research flock which is free from classical scrapie. (19208228)
2009
19
Immunohistochemical characterisation of classical scrapie neuropathology in sheep. (19515381)
2009
20
Cells expressing anchorless prion protein are resistant to scrapie infection. (19225008)
2009
21
Quantitative reverse-transcription polymerase chain reaction analysis of Alzheimer's-associated genes in mouse scrapie. (19697242)
2009
22
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein. (19223590)
2009
23
Prions are secreted in milk from clinically normal scrapie-exposed sheep. (19494004)
2009
24
Failure to transmit scrapie infection by transferring preimplantation embryos from naturally infected donor sheep. (19604572)
2009
25
Atypical PrPsc distribution in goats naturally affected with scrapie. (18295782)
2008
26
Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs. (18548327)
2008
27
Epidemiological characteristics of classical scrapie outbreaks in 30 sheep flocks in the United Kingdom. (19098982)
2008
28
The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie. (19008382)
2008
29
Effects of new amphotericin analogues on the scrapie isoform of the prion protein. (18691635)
2008
30
Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice. (18768980)
2008
31
Diagnosis of preclinical scrapie in live sheep by the immunohistochemical examination of rectal biopsies. (18375983)
2008
32
The importance of the PrP genotype in active surveillance for ovine scrapie. (17588284)
2008
33
Identification of differentially expressed genes in ileal Peyer's patch of scrapie-infected sheep using RNA arbitrarily primed PCR. (18373840)
2008
34
An evaluation of scrapie surveillance in the United States. (17482695)
2007
35
Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy. (17296770)
2007
36
Atypical scrapie in a Swiss goat and implications for transmissible spongiform encephalopathy surveillance. (17459826)
2007
37
Epidemiological and genetical differences between classical and atypical scrapie cases. (17156738)
2007
38
Exposure of sheep scrapie brain homogenate to rumen-simulating conditions does not result in a reduction of PrP(Sc) levels. (17576225)
2007
39
Increased expression of glial cell line-derived neurotrophic factor (GDNF) in the brains of scrapie-infected mice. (17101222)
2006
40
Synergistic and strain-specific effects of bovine spongiform encephalopathy and scrapie prions in the cell-free conversion of recombinant prion protein. (17098995)
2006
41
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines. (15869502)
2005
42
Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequences. (15215050)
2004
43
Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. (15026410)
2004
44
Scrapie and chronic wasting disease. (12733429)
2003
45
Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor). (12918830)
2003
46
Risks of transmitting scrapie and bovine spongiform encephalopathy by semen and embryos. (9329121)
1997
47
Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period. (8922485)
1996
48
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
49
Topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (Odocoileus hemionus hemionus). (1713390)
1991
50
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells. (1675247)
1991

Genetic Variations for Scrapie

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Expression for genes affiliated with Scrapie

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scrapie

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Pathways for genes affiliated with Scrapie

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Compounds for genes affiliated with Scrapie

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank
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Compounds related to Scrapie according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1inulin4410.3CST3, CLU
2kainate44 2811.2CLU, BLVRB, MAPT, PVALB
3folate4410.2CST3, MT2A, MAPT, CLU
4formaldehyde44 2411.2BLVRB, MAPT, PRNP, PVALB
5methionine4410.2PVALB, CST3, PRND, PRNP, MAPT
6n acetylcysteine4410.1CLU, MAPT, MT2A, CST3
7paraffin4410.1PVALB, PRNP, MAPT, BLVRB, CLU
8silver4410.0MAPT, CST3, PVALB
9superoxide44 2411.0CST3, MT2A, PRNP, BLVRB, CLU
10zinc44 2410.9CLU, MAPT, PRNP, MT2A, PVALB
11latex449.8PVALB, CST3, FLOT1
12calcium44 49 11 2412.5PVALB, CST3, MT2A, PRNP, MYL4, BLVRB

GO Terms for genes affiliated with Scrapie

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16Gene Ontology
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Biological processes related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular copper ion homeostasisGO:00687810.2PRNP, PRND, MT2A

Products for genes affiliated with Scrapie

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Scrapie

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet