MCID: SCR011
MIFTS: 37

Scrapie malady

Summaries for Scrapie

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64Wikipedia, 33MalaCards
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Wikipedia:64 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards: Scrapie is related to bovine spongiform encephalopathy and alzheimer's disease. An important gene associated with Scrapie is PRNP (prion protein). The compounds inulin and kainate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node.

Aliases & Classifications for Scrapie

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

scrapie 8 10 45 61


External Ids:

Disease Ontology8 DOID:5434
SNOMED-CT57 35103004
MeSH35 D012608

Related Diseases for Scrapie

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Clinical Features for Scrapie

Drugs & Therapeutics for Scrapie

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Scrapie

Drug clinical trials:

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Search NIH Clinical Center for Scrapie

Search CenterWatch for Scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

Sources:
33MalaCards
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MalaCards organs/tissues related to Scrapie:

33
Bone marrow, Whole blood, Lymph node, Spleen, Brain, Cortex, Cerebellum, Retina, Small intestine, Kidney, Liver, Salivary gland, Adrenal gland, Skin, Placenta, Tonsil, T cells, B cells, Endothelial, Medulla oblongata, Adrenal cortex, Pituitary

Animal Models for Scrapie or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Scrapie

Sources:
51PubMed
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Articles related to Scrapie:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Unsuccessful oral transmission of scrapie from British sheep to cattle. (23723100)
2013
2
PrP-associated resistance to scrapie in five highly infected goat herds. (23100359)
2013
3
Transmission of classical scrapie via goat milk. (23625249)
2013
4
Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep. (23601183)
2013
5
Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis. (24229425)
2013
6
Different antigenicities of the N-terminal region of cellular and scrapie prion proteins. (24117858)
2013
7
Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006 E9 2011). (23388443)
2013
8
Urine proteins identified by two-dimensional differential gel electrophoresis facilitate the differential diagnoses of scrapie. (23704971)
2013
9
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
10
The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection. (22031932)
2012
11
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. (23139828)
2012
12
Propagation of ovine prions from "poor" transmitter scrapie isolates in ovine PrP transgenic mice. (22120785)
2012
13
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
14
Overexpression of Shadoo protein in transgenic mice does not impact the pathogenesis of scrapie. (21458534)
2011
15
Spiroplasma found in the eyes of scrapie affected sheep. (21199275)
2011
16
Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks. (21314971)
2011
17
Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma. (22112371)
2011
18
Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. (21647368)
2011
19
The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep. (20219126)
2010
20
Pathological phenotype of sheep scrapie after blood transfusion. (19625026)
2010
21
Bovine macrophage degradation of scrapie and BSE PrPSc. (19647878)
2010
22
Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie. (20107013)
2010
23
Diagnosis of the first cases of scrapie in Poland. (19716323)
2010
24
Atypical scrapie: impact on eradication policies. (19910225)
2010
25
Evaluation of prion deposits and microglial activation in scrapie-infected mice using molecular imaging probes. (20376566)
2010
26
Distinct spatial activation of intrinsic and extrinsic apoptosis pathways in natural scrapie: association with prion-related lesions. (19401142)
2009
27
Olfactory system involvement in natural scrapie disease. (19158242)
2009
28
Evaluation of the possible transmission of BSE and scrapie to gilthead sea bream (Sparus aurata). (19636413)
2009
29
Differential expression of Prnp and Sprn in scrapie infected sheep also reveals Prnp genotype specific differences. (19070601)
2009
30
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy. (18834644)
2009
31
Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways. (19107494)
2009
32
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
33
Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats. (19008408)
2008
34
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
35
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
36
Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters. (17181988)
2007
37
Selection for scrapie resistance and simultaneous restriction of inbreeding in the rare sheep breed "Mergellander". (17095110)
2007
38
Explaining the heterogeneous scrapie surveillance figures across Europe: a meta-regression approach. (17598881)
2007
39
Detection of preclinical scrapie from serum by infrared spectroscopy and chemometrics. (17036215)
2007
40
PrPSc in salivary glands of scrapie-affected sheep. (17301130)
2007
41
Quantification of Peyer's patches in Cheviot sheep for future scrapie pathogenesis studies. (17320972)
2007
42
Urinary excretion and blood level of prions in scrapie-infected hamsters. (17872544)
2007
43
Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model. (17437544)
2007
44
Early and rapid engraftment of bone marrow-derived microglia in scrapie. (17093096)
2006
45
Disease-associated F198S mutation increases the propensity of the recombinant prion protein for conformational conversion to scrapie-like form. (12372829)
2002
46
Differential diagnosis of infections with the bovine spongiform encephalopathy (BSE) and scrapie agents in sheep. (11798244)
2001
47
Similar signature of the prion protein in natural sheep scrapie and bovine spongiform encephalopathy-linked diseases. (10523578)
1999
48
Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues. (7913757)
1994
49
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
50
Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. (1348570)
1992

Genetic Variations for Scrapie

Expression for genes affiliated with Scrapie

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

Compounds for genes affiliated with Scrapie

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank
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Compounds related to Scrapie according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1inulin4510.3CST3, CLU
2kainate45 2911.2CLU, BLVRB, MAPT, PVALB
3folate4510.2CST3, MT2A, MAPT, CLU
4formaldehyde45 2411.2BLVRB, MAPT, PRNP, PVALB
5methionine4510.2PVALB, CST3, PRND, PRNP, MAPT
6n acetylcysteine4510.1CLU, MAPT, MT2A, CST3
7paraffin4510.1PVALB, PRNP, MAPT, BLVRB, CLU
8silver4510.0MAPT, CST3, PVALB
9superoxide45 2411.0CST3, MT2A, PRNP, BLVRB, CLU
10zinc45 2410.9CLU, MAPT, PRNP, MT2A, PVALB
11latex459.8PVALB, CST3, FLOT1
12calcium45 50 11 2412.5PVALB, CST3, MT2A, PRNP, MYL4, BLVRB

GO Terms for genes affiliated with Scrapie

Sources:
16Gene Ontology
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Biological processes related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular copper ion homeostasisGO:00687810.2PRNP, PRND, MT2A

Products for genes affiliated with Scrapie

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  • Lysates
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Sources for Scrapie

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet