MCID: SCR011
MIFTS: 44

Scrapie malady

Neuronal diseases category

Summaries for Scrapie

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66Wikipedia, 34MalaCards
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Wikipedia:66 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards: Scrapie is related to prion disease and creutzfeldt-jakob disease. An important gene associated with Scrapie is PRNP (prion protein). The compounds guanidine hydrochloride and inulin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related mouse phenotypes are other and tumorigenesis.

Aliases & Classifications for Scrapie

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

scrapie 9 11 46 63


External Ids:

Disease Ontology9 DOID:5434
SNOMED-CT59 35103004
MeSH36 D012608

Related Diseases for Scrapie

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Scrapie via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1prion disease30.8CLU, PRNP, MAPT
2creutzfeldt-jakob disease30.6PRND, PRNP, MSMB, MAPT, CST3
3variant creutzfeldt-jakob disease30.4MSMB, PRNP
4memory impairment30.0MAPT, PRNP
5alzheimer's disease29.7CLU, PRND, PRNP, MAPT, CST3
6chronic wasting disease10.5
7neuronitis10.5
8kuru10.3
9tonsillitis10.1
10encephalitis10.1
11neuroblastoma10.1
12hemorrhage, intracerebral10.0CST3, PRNP
13progressive supranuclear palsy10.0MAPT, PRNP
14lewy body dementia10.0PRNP, MAPT
15spinocerebellar ataxia10.0MAPT, PRNP
16multiple system atrophy10.0MAPT, PRNP
17myositis10.0PRNP, MAPT
18familial creutzfeldt-jakob disease10.0MSMB, PRNP, PRND
19toxic encephalopathy10.0MAPT, PRNP
20brain disease10.0MAPT, PRNP
21congenital heart disease10.0CST3, CLU
22acute myocardial infarction10.0CST3, CLU
23huntington's disease10.0MAPT, PRNP
24pick's disease10.0CLU, MAPT
25fibrosarcoma10.0CST3, CLU
26proteinuria10.0CST3, CLU
27infertility10.0MSMB, PRND, CLU
28atherosclerosis10.0CLU, PRNP, CST3
29pharyngitis10.0
30neuroaxonal dystrophy10.0
31louping ill10.0
32cerebritis10.0
33encephalomyelitis10.0
34mastitis10.0
35mouth disease10.0
36retinitis10.0
37neurologic diseases10.0
38genetic prion diseases10.0
39endotheliitis10.0
40cerebral amyloid angiopathy10.0CST3, MAPT, PRNP
41vascular dementia10.0PRNP, MAPT, CST3
42amyloid tumor10.0PRNP, MAPT, CST3
43amyotrophic lateral sclerosis10.0CST3, MAPT, PRNP
44cerebrovascular disease10.0CST3, MAPT, PRNP
45coronary artery disease10.0CLU, CST3
46malignant glioma9.9CLU, PRNP, MAPT
47ischemia9.9CST3, MAPT, CLU
48adenocarcinoma9.9CLU, MSMB, MAPT
49amyloidosis9.9CLU, PRNP, MAPT, CST3
50dementia9.9CST3, MAPT, PRNP, CLU

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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34MalaCards
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MalaCards organs/tissues related to Scrapie:

34
Brain, Testes, Lymph node, T cells, Retina, Spleen, B cells, Tonsil, Skin, Placenta, Medulla oblongata, Kidney, Cerebellum, Cortex, Pituitary, Liver, Adrenal gland, Salivary gland, Bone, Endothelial, Eye

Animal Models for Scrapie or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Scrapie:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.7MAPT, PRNP, CLU
2MP:00020068.6CST3, MAPT, MSMB
3MP:00053697.8CST3, MAPT, PRNP, CLU
4MP:00053877.6CLU, PRND, PRNP, MSMB, MAPT
5MP:00036317.5CLU, PRND, PRNP, MAPT, CST3

Publications for Scrapie

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Sources:
53PubMed
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Articles related to Scrapie:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
2
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
3
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
4
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
5
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
6
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
7
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
8
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
9
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
10
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. (20085753)
2010
11
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
12
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
13
Scrapie genetics before the discovery of prions. (19707236)
2010
14
Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. (19751582)
2009
15
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
16
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
17
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. (19606066)
2009
18
Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep. (19577317)
2009
19
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
20
Distinct spatial activation of intrinsic and extrinsic apoptosis pathways in natural scrapie: association with prion-related lesions. (19401142)
2009
21
Olfactory system involvement in natural scrapie disease. (19158242)
2009
22
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
23
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
24
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
25
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. (18667494)
2008
26
Detection of prion infectivity in fat tissues of scrapie-infected mice. (19057664)
2008
27
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
28
Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility. (17361441)
2007
29
Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. (19164931)
2007
30
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
31
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
32
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
33
An evaluation of scrapie surveillance in the United States. (17482695)
2007
34
Effectiveness of capillary electrophoresis fluoroimmunoassay of blood PrpSc for evaluation of scrapie pathogenesis in sheep. (17823402)
2007
35
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
36
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
37
Infectivity of scrapie prion protein (PrPSc) following in vitro digestion with bovine gastrointestinal microbiota. (17542960)
2007
38
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
39
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
40
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
41
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)
2006
42
Scrapie and chronic wasting disease. (12733429)
2003
43
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
44
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
45
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
46
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
47
Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. (8372644)
1993
48
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
49
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991
50
Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)
1990

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Scrapie

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Pathways for genes affiliated with Scrapie

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Compounds for genes affiliated with Scrapie

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46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 52PharmGKB
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Compounds related to Scrapie according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride469.9MSMB, PRNP
2inulin469.8CST3, CLU
3kininogen469.7CST3, CLU
4formate469.6MAPT, PRNP
5guanidine46 25 1211.6MAPT, PRNP
6homocysteine46 2510.6CLU, CST3
7sodium dodecylsulfate469.5PRNP, MAPT
8vitamin b12469.5MAPT, CST3
9silver469.4CST3, MAPT
10colchicine46 62 3 30 1213.3MAPT, CLU
11agarose469.3CLU, PRNP, CST3
12polysaccharide469.3CST3, PRNP, CLU
13kainate46 3010.3MAPT, CLU
14superoxide46 2510.3CST3, PRNP, CLU
15formaldehyde46 2510.2MAPT, PRNP
16sialic acid469.2CLU, CST3
17cholesterol46 30 25 1212.2CLU, PRNP, CST3
18valine469.2PRND, PRNP, MAPT
19urea46 25 1211.1CST3, MAPT
20steroid469.1CST3, MSMB, CLU
21aspartate469.1PRNP, MAPT, CST3
22paraffin469.0CLU, PRNP, MAPT
23proline469.0MAPT, PRNP, CLU
24heparin46 30 25 1212.0MAPT, PRNP, CLU
25arginine469.0CST3, MAPT, PRNP
26h2o2469.0MAPT, PRNP, CLU
27folate468.9CST3, MAPT, CLU
28n acetylcysteine468.9CLU, MAPT, CST3
29threonine468.9CST3, MAPT, PRNP
30lactate468.9CLU, MAPT, CST3
31testosterone46 62 25 1211.8CLU, MSMB, MAPT
32zinc46 259.8CLU, PRNP, MAPT
33alanine468.8CST3, MAPT, PRNP
34glutamate468.7CLU, PRNP, MAPT
35docetaxel46 52 62 1211.7CLU, MAPT
36methionine468.7CST3, MAPT, PRNP, PRND
37calcium46 52 25 1211.5CLU, PRNP, MSMB, CST3
38serine468.5CLU, PRNP, MAPT, CST3
39cysteine468.4CST3, MAPT, MSMB, CLU

GO Terms for genes affiliated with Scrapie

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17Gene Ontology
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Cellular components related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312259.6PRNP, PRND

Molecular functions related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:0080179.2MAPT, PRNP

Products for genes affiliated with Scrapie

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Sources for Scrapie

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet