Aliases & Classifications for Scrapie

MalaCards integrated aliases for Scrapie:

Name: Scrapie 12 72 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 41 D012608
SNOMED-CT 64 35103004
UMLS 69 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to chronic wasting disease and creutzfeldt-jakob disease. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related phenotypes are growth/size/body region and nervous system

Wikipedia : 72 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 chronic wasting disease 31.2 PRNP SPRN
2 creutzfeldt-jakob disease 31.1 ENO2 MSMB PRND PRNP RPSA SPRN
3 prion disease 28.5 ADAM10 APP ENO2 MAP2 MSMB PRND
4 alzheimer disease 28.3 ADAM10 APP CLU GFAP MAP2 PRNP
5 kuru 11.3
6 genetic prion diseases 11.2
7 encephalopathy 10.6
8 fatal familial insomnia 10.4 MSMB PRNP
9 akinetic mutism 10.3 ENO2 PRNP
10 binswanger's disease 10.3 APP GFAP
11 neuronitis 10.3
12 intracranial cysts 10.3 ENO2 GFAP
13 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 GFAP
14 melanotic medulloblastoma 10.3 ENO2 GFAP
15 cerebellar medulloblastoma 10.3 ENO2 GFAP
16 gerstmann-straussler disease 10.3 APP MSMB PRNP
17 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 GFAP
18 subependymal glioma 10.3 ENO2 GFAP
19 cerebral neuroblastoma 10.3 ENO2 GFAP
20 cerebral hemorrhage 10.3 APP GFAP PRNP
21 leukoencephalopathy, hereditary diffuse, with spheroids 10.3 APP GFAP PRNP
22 benign ependymoma 10.3 ENO2 GFAP
23 astroblastoma 10.3 ENO2 GFAP
24 toxic encephalopathy 10.3 APP GFAP PRNP
25 plexiform schwannoma 10.3 ENO2 GFAP
26 cerebral ventricle cancer 10.3 ENO2 GFAP
27 cerebrum cancer 10.3 ENO2 GFAP
28 pineal gland cancer 10.3 ENO2 GFAP
29 nervous system disease 10.3 APP GFAP PRNP
30 melanotic neuroectodermal tumor 10.3 ENO2 GFAP
31 subependymoma 10.3 ENO2 GFAP
32 supratentorial cancer 10.2 ENO2 GFAP
33 pineocytoma 10.2 ENO2 GFAP
34 microcystic meningioma 10.2 ENO2 GFAP
35 central nervous system disease 10.2 APP GFAP PRNP
36 papillary ependymoma 10.2 ENO2 GFAP
37 subependymal giant cell astrocytoma 10.2 ENO2 GFAP
38 granular cell tumor 10.2 ENO2 GFAP
39 angiomatous meningioma 10.2 GFAP TF
40 integumentary system benign neoplasm 10.2 ENO2 GFAP
41 congenital disorder of glycosylation, type ia 10.1 CLU TF
42 cystic teratoma 10.1 ENO2 GFAP
43 traumatic brain injury 10.1 ENO2 GFAP
44 dysgerminoma of ovary 10.1 ENO2 GFAP
45 chiari malformation 10.1 GFAP MAP2
46 dysembryoplastic neuroepithelial tumor 10.1 GFAP MAP2
47 medullomyoblastoma 10.1 ENO2 GFAP
48 hemimegalencephaly 10.1 GFAP MAP2
49 aging 10.0
50 hydrocephalus 10.0 APP ENO2 GFAP

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 ADAM10 APP ENO2 GFAP MAP2 PRNP
2 nervous system MP:0003631 9.28 ADAM10 APP CLU ENO2 GFAP MAP2

Drugs & Therapeutics for Scrapie

Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2 Anesthetics Phase 4
3 Anesthetics, Local Phase 4
4 Central Nervous System Depressants Phase 4
5 Peripheral Nervous System Agents Phase 4
6
Ethanol Approved Phase 3 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Recruiting NCT03250507 Phase 4 Bupivacaine;Liposomal bupivacaine;Saline
2 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
3 Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home Recruiting NCT02346305
4 Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Recruiting NCT02507505

Search NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

38
Brain, Testes, Spleen, Lymph Node, Placenta, Retina, T Cells

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 729)
# Title Authors Year
1
Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie. ( 29240410 )
2018
2
Screening of intact yeasts and cell extracts to reduce Scrapie prions during biotransformation of food waste. ( 29422098 )
2018
3
The effect of polymorphisms at codon 146 of the goat PRNP gene on susceptibility to challenge with classical scrapie by different routes. ( 28878088 )
2017
4
Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. ( 29202042 )
2017
5
A cross-sectional study of PRNP gene in two native Sicilian goat populations in Italy: a relation between prion gene polymorphisms and scrapie incidence. ( 28674232 )
2017
6
Do we need to explain the occurrence of atypical scrapie? ( 28432247 )
2017
7
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. ( 28910420 )
2017
8
Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. ( 28754560 )
2017
9
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. ( 28636656 )
2017
10
Scrapie, CWD, and Transmissible Mink Encephalopathy. ( 28838664 )
2017
11
Precision in the design of an experimental study deflects the significance of proteinase-activated receptor 2 expression in scrapie-inoculated mice. ( 28613153 )
2017
12
Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep. ( 28472956 )
2017
13
Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein. ( 28759310 )
2017
14
Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice. ( 29220360 )
2017
15
Experimental transmission to a calf of an isolate of Spanish classical scrapie. ( 28920852 )
2017
16
An in vitro model for assessing effective scrapie decontamination. ( 28757014 )
2017
17
Protein misfolding cyclic amplification corroborates the absence of PrP(Sc) accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie. ( 28619160 )
2017
18
A novel approach for scrapie-associated prion (PrP(Sc)) detection in blood using the competitive affinity of an aggregate-specific antibody and streptavidin to PrP(Sc). ( 28942337 )
2017
19
Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. ( 28758631 )
2017
20
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (BSE) and scrapie in Great Britain. ( 28816650 )
2017
21
Reduction of NF-I_B (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. ( 28783945 )
2017
22
Case-control study on the use of pituitary-derived hormones from sheep as a potential risk factor for the occurrence of atypical scrapie in Great Britain. ( 28213529 )
2017
23
Classical scrapie transmission in ARR/ARR genotype sheep. ( 28721847 )
2017
24
Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection. ( 28968141 )
2017
25
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. ( 27936597 )
2017
26
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. ( 28063003 )
2017
27
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. ( 27751198 )
2017
28
Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats. ( 28691895 )
2017
29
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. ( 27211330 )
2016
30
Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease. ( 27463540 )
2016
31
Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals. ( 27590859 )
2016
32
CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection. ( 26773845 )
2016
33
Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. ( 27033930 )
2016
34
Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease. ( 27109462 )
2016
35
Goat K222-PrP(C) polymorphic variant does not provide resistance to atypical scrapie in transgenic mice. ( 27659200 )
2016
36
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. ( 26847623 )
2016
37
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions. ( 27259989 )
2016
38
Temporal Resolution of Misfolded Prion Protein Transport, Accumulation, Glial Activation, and Neuronal Death in the Retinas of Mice Inoculated with Scrapie. ( 27521336 )
2016
39
Atypical scrapie in Australia. ( 27807855 )
2016
40
Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion. ( 26653410 )
2016
41
Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. ( 27021907 )
2016
42
Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice. ( 27221113 )
2016
43
Identification of the first case of atypical scrapie in Japan. ( 27616556 )
2016
44
Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs. ( 27417309 )
2016
45
Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain. ( 26976340 )
2016
46
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. ( 27921253 )
2016
47
Altered trafficking of abnormal prion protein in atypical scrapie: Prion protein accumulation in oligodendroglial inner mesaxons. ( 26750308 )
2016
48
Transmission of atypical scrapie to homozygous ARQ sheep. ( 27320968 )
2016
49
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells. ( 27537339 )
2016
50
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models. ( 26887380 )
2016

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 APP CLU ENO2 GFAP MAP2 PRNP
2 10.99 ADAM10 APP MT2A PRNP
3 10.67 APP PRNP
4 10.52 ADAM10 APP

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 APP CLU MSMB PRND SCRG1 SPRN
2 extracellular space GO:0005615 9.7 ADAM10 APP CLU ENO2 MSMB SCRG1
3 anchored component of membrane GO:0031225 9.5 PRND PRNP SPRN
4 dendritic shaft GO:0043198 9.4 APP MAP2
5 cell surface GO:0009986 9.35 ADAM10 APP CLU PRNP TF
6 anchored component of external side of plasma membrane GO:0031362 9.26 PRND PRNP
7 astrocyte projection GO:0097449 8.62 APP GFAP

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.61 APP CLU TF
2 positive regulation of neuron death GO:1901216 9.51 CLU PRNP
3 dendrite development GO:0016358 9.49 APP MAP2
4 cellular response to amyloid-beta GO:1904646 9.48 APP PRNP
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.46 CLU TF
6 positive regulation of amyloid-beta formation GO:1902004 9.4 APP CLU
7 negative regulation of amyloid-beta formation GO:1902430 9.37 CLU PRNP
8 negative regulation of long-term synaptic potentiation GO:1900272 9.32 APP PRNP
9 modulation of age-related behavioral decline GO:0090647 9.26 APP PRNP
10 neuron projection maintenance GO:1990535 9.16 APP PRNP
11 positive regulation of amyloid fibril formation GO:1905908 8.96 APP CLU
12 cellular copper ion homeostasis GO:0006878 8.92 APP MT2A PRND PRNP

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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