Aliases & Classifications for Scrapie

MalaCards integrated aliases for Scrapie:

Name: Scrapie 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5434
MeSH 42 D012608
SNOMED-CT 64 35103004
UMLS 69 C0036457

Summaries for Scrapie

MalaCards based summary : Scrapie is related to prion disease and creutzfeldt-jakob disease. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related phenotypes are growth/size/body region and nervous system

Wikipedia : 72 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

Related Diseases for Scrapie

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 prion disease 11.2
2 creutzfeldt-jakob disease 11.2
3 kuru 11.1
4 genetic prion diseases 11.1
5 cerebral ventricle cancer 10.7 PRNP SPRN
6 encephalopathy 10.5
7 macrocephaly, alopecia, cutis laxa, and scoliosis 10.5 MSMB PRND PRNP
8 penis basal cell carcinoma 10.5 ENO2 PRNP
9 bladder cancer, childhood 10.5 APP GFAP
10 meningitis and encephalitis 10.5 ENO2 GFAP
11 intellectual disability-polydactyly-uncombable hair syndrome 10.5 ENO2 GFAP
12 nodular medulloblastoma 10.5 ENO2 GFAP
13 vulvar benign neoplasm 10.5 ENO2 GFAP
14 huntington disease-like 1 10.5 APP MSMB PRNP
15 brain glioma 10.5 ENO2 GFAP
16 cauda equina intradural extramedullary astrocytoma 10.5 ENO2 GFAP
17 rh isoimmunization 10.5 ENO2 GFAP
18 cervical squamous cell carcinoma 10.5 APP GFAP PRNP
19 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.5 APP GFAP PRNP
20 cauda equina neoplasm 10.4 ENO2 GFAP
21 axonal neuropathy 10.4 ENO2 GFAP
22 ovarian cystadenocarcinoma 10.4 APP GFAP PRNP
23 demyelinating disease 10.4 ENO2 GFAP
24 childhood choroid plexus cancer 10.4 ENO2 GFAP
25 brachial plexus neuritis 10.4 ENO2 GFAP
26 malignant granular cell myoblastoma 10.4 ENO2 GFAP
27 behcet's syndrome arthropathy 10.4 ENO2 GFAP
28 prostate carcinoma in situ 10.4 APP GFAP PRNP
29 sudden sensorineural hearing loss 10.4 ENO2 GFAP
30 pineoblastoma 10.4 ENO2 GFAP
31 pituitary dwarfism with large sella turcica 10.4 ENO2 GFAP
32 ulnar neuropathy 10.4 ENO2 GFAP
33 hepatic angiomyolipoma 10.4 APP GFAP PRNP
34 pediatric ependymoma 10.4 ENO2 GFAP
35 mixed epithelial stromal tumour 10.3 ENO2 GFAP
36 connective tissue benign neoplasm 10.3 ENO2 GFAP
37 skin glomus tumor 10.3 ENO2 GFAP
38 posterior foramen magnum meningioma 10.3 GFAP TF
39 xeroderma pigmentosum, group f 10.3 CLU TF
40 pacinian tumor 10.3 ENO2 GFAP
41 ulcerative colitis 10.2 ENO2 GFAP
42 chronic wasting disease 10.2
43 neuronitis 10.2
44 nasal cavity squamous cell carcinoma 10.2 ENO2 GFAP
45 chilaiditi syndrome 10.2 GFAP MAP2
46 adenofibroma 10.2 GFAP MAP2
47 peritoneal benign neoplasm 10.2 ENO2 GFAP
48 hemoglobinemia 10.2 GFAP MAP2
49 melanotic medulloblastoma 10.1 ENO2 GFAP
50 ichthyosis lamellar 1 10.1 APP ENO2 GFAP

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to Scrapie

Symptoms & Phenotypes for Scrapie

MGI Mouse Phenotypes related to Scrapie:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 PRNP RPSA SPRN TF ADAM10 APP
2 nervous system MP:0003631 9.28 ADAM10 APP CLU ENO2 GFAP MAP2

Drugs & Therapeutics for Scrapie

Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2 Anesthetics Phase 4
3 Anesthetics, Local Phase 4
4 Central Nervous System Depressants Phase 4
5 Peripheral Nervous System Agents Phase 4
6
Ethanol Approved Phase 3 64-17-5 702

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Recruiting NCT03250507 Phase 4 Bupivacaine;Liposomal bupivacaine;Saline
2 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
3 Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home Unknown status NCT02346305
4 Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Recruiting NCT02507505

Search NIH Clinical Center for Scrapie

Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

Anatomical Context for Scrapie

MalaCards organs/tissues related to Scrapie:

39
Brain, Testes, Spleen, Lymph Node, Placenta, Retina, T Cells

Publications for Scrapie

Articles related to Scrapie:

(show top 50) (show all 724)
id Title Authors Year
1
An in vitro model for assessing effective scrapie decontamination. ( 28757014 )
2017
2
Case-control study on the use of pituitary-derived hormones from sheep as a potential risk factor for the occurrence of atypical scrapie in Great Britain. ( 28213529 )
2017
3
Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. ( 28754560 )
2017
4
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. ( 28063003 )
2017
5
Reduction of NF-I_B (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. ( 28783945 )
2017
6
Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein. ( 28759310 )
2017
7
Precision in the design of an experimental study deflects the significance of proteinase-activated receptor 2 expression in scrapie-inoculated mice. ( 28613153 )
2017
8
Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. ( 28910420 )
2017
9
Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. ( 28758631 )
2017
10
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. ( 27751198 )
2017
11
Classical scrapie transmission in ARR/ARR genotype sheep. ( 28721847 )
2017
12
Scrapie, CWD, and Transmissible Mink Encephalopathy. ( 28838664 )
2017
13
Do we need to explain the occurrence of atypical scrapie? ( 28432247 )
2017
14
Experimental transmission to a calf of an isolate of Spanish classical scrapie. ( 28920852 )
2017
15
The effect of polymorphisms at codon 146 of the goat PRNP gene on susceptibility to challenge with classical scrapie by different routes. ( 28878088 )
2017
16
A novel approach for scrapie-associated prion (PrP(Sc)) detection in blood using the competitive affinity of an aggregate-specific antibody and streptavidin to PrP(Sc). ( 28942337 )
2017
17
A cross-sectional study of PRNP gene in two native Sicilian goat populations in Italy: a relation between prion gene polymorphisms and scrapie incidence. ( 28674232 )
2017
18
Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (BSE) and scrapie in Great Britain. ( 28816650 )
2017
19
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. ( 28636656 )
2017
20
Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats. ( 28691895 )
2017
21
Protein misfolding cyclic amplification corroborates the absence of PrP(Sc) accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie. ( 28619160 )
2017
22
Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep. ( 28472956 )
2017
23
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. ( 27936597 )
2017
24
Transmission of atypical scrapie to homozygous ARQ sheep. ( 27320968 )
2016
25
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. ( 27211330 )
2016
26
MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15. ( 27826142 )
2016
27
Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia. ( 26807844 )
2016
28
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. ( 27317933 )
2016
29
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. ( 26655166 )
2016
30
Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. ( 27033930 )
2016
31
Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals. ( 27590859 )
2016
32
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. ( 26847623 )
2016
33
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells. ( 27537339 )
2016
34
In this issue - December 2016: Chemical immobilisation of free-range cattlea88A^a88Dairy cow progesterone assaya88A^a88Atypical scrapie in sheepa88A^a88Antibiotic resistance in healthy dogsa88A^a88Contrast CT in dermoid sinusesa88A^ Pneumorrhachis in a doga88A^a88Dorsal perineal artery for axial pattern flap surgery in a cata88A^a88Inducing emesis in dogs. ( 27891596 )
2016
35
Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain. ( 26976340 )
2016
36
Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic. ( 27215403 )
2016
37
Isolation of a Defective Prion Mutant from Natural Scrapie. ( 27880822 )
2016
38
Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats. ( 27005313 )
2016
39
Prion protein scrapie and the normal cellular prion protein. ( 26645475 )
2016
40
Evidence of scrapie transmission to sheep via goat milk. ( 27640200 )
2016
41
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. ( 27393736 )
2016
42
Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health. ( 27928518 )
2016
43
Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice. ( 27221113 )
2016
44
Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease. ( 27463540 )
2016
45
Atypical scrapie in Australia. ( 27807855 )
2016
46
Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. ( 26755614 )
2016
47
Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion. ( 26653410 )
2016
48
Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. ( 27991723 )
2016
49
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. ( 27921253 )
2016
50
Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains. ( 26936223 )
2016

Variations for Scrapie

Expression for Scrapie

Search GEO for disease gene expression data for Scrapie.

Pathways for Scrapie

Pathways related to Scrapie according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 APP CLU ENO2 GFAP MAP2 PRNP
2 10.99 ADAM10 APP MT2A PRNP
3 10.67 APP PRNP
4 10.57 ADAM10 APP

GO Terms for Scrapie

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 APP CLU MSMB PRND SCRG1 SPRN
2 extracellular space GO:0005615 9.7 ADAM10 APP CLU ENO2 MSMB SCRG1
3 anchored component of membrane GO:0031225 9.5 PRND PRNP SPRN
4 cell surface GO:0009986 9.35 ADAM10 APP CLU PRNP TF
5 anchored component of external side of plasma membrane GO:0031362 8.96 PRNP
6 astrocyte projection GO:0097449 8.32 APP

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.54 APP CLU TF
2 positive regulation of neuron death GO:1901216 9.46 CLU PRNP
3 positive regulation of receptor-mediated endocytosis GO:0048260 9.4 CLU TF
4 dendrite development GO:0016358 9.13 APP
5 cellular response to beta-amyloid GO:1904646 9.02 APP
6 positive regulation of beta-amyloid formation GO:1902004 8.96 CLU
7 cellular copper ion homeostasis GO:0006878 8.92 APP MT2A PRND PRNP
8 negative regulation of beta-amyloid formation GO:1902430 8.85 CLU
9 modulation of age-related behavioral decline GO:0090647 8.65 APP

Sources for Scrapie

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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