Aliases & Classifications for Scrapie

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Aliases & Descriptions for Scrapie:

Name: Scrapie 10 47 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:5434
SNOMED-CT59 35103004
MeSH36 D012608
UMLS65 C0036457

Summaries for Scrapie

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Wikipedia:68 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to creutzfeldt-jakob disease and encephalopathy. An important gene associated with Scrapie is PRNP (Prion Protein), and among its related pathways are Glypican 1 network and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, prostate and b cells, and related mouse phenotypes are growth/size/body region and nervous system.

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1creutzfeldt-jakob disease10.8
2encephalopathy10.6
3familial mediterranean fever type 110.6PRND, PRNP
4localized pagetoid reticulosis10.6PRND, PRNP
5harp syndrome10.6PRND, PRNP
6prion disease with protracted course10.5APP, PRNP
7birdshot chorioretinopathy10.4APP, GFAP
8prion disease10.4
9personality disorder10.4APP, SPRN
10chronic wasting disease10.3
11neuronitis10.3
12bronchitis10.3GFAP, MAP2
13unverricht-lundborg syndrome10.3PRNP, RPSA, SPRN
14upper lip cancer10.3APP, GFAP, PRNP
15selective igg deficiency disease10.2GFAP, MAP2
16communicating hydrocephalus10.2APP, GFAP
17clear cell ependymoma10.2GFAP, MAP2
18atopic dermatitis10.2APP, GFAP, PRNP
19lipoma of the rectum10.1GFAP, MAP2
20mucinous cystadenocarcinoma10.1MAP2, PRNP
21kuru10.1
22inherited metabolic disorder10.0GFAP, TF
23iodine hypothyroidism10.0GFAP, MAP2
24neuroblastoma10.0
25alzheimer disease9.9
26tonsillitis9.9
27pharyngitis9.9
28encephalitis9.9
29jervell and lange-nielsen syndrome 29.8APP, GFAP, MAP2, PRNP
30louping ill9.8
31mastitis9.8
32neuroaxonal dystrophy9.8
33cerebritis9.8
34retinitis9.8
35mouth disease9.8
36peritonitis9.8
37neurologic diseases9.8
38genetic prion diseases9.8
39sporadic creutzfeldt-jakob disease9.8
40endotheliitis9.8
41viral laryngitis9.7GFAP, MAP2
42xeroderma pigmentosum, group f9.7CLU, TF
43gerstmann-straussler disease9.7APP, PRND, PRNP, RPSA, SPRN
44al gazali aziz salem syndrome9.7APP, CLU
45hypersensitivity syndrome, carbamazepine-induced9.0ADAM10, APP, CLU, GFAP, PRNP
46breast capillary hemangioma8.9ADAM10, APP, MAP2, PRND, PRNP, RPSA
47intrahepatic bile duct adenoma5.9ADAM10, APP, CLU, GFAP, LDLRAP1, MAP2

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at HomeRecruitingNCT02346305

Search NIH Clinical Center for Scrapie


Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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MalaCards organs/tissues related to Scrapie:

33
Brain, Prostate, B cells, Thyroid, Breast, Testes, Lung

Animal Models for Scrapie or affiliated genes

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MGI Mouse Phenotypes related to Scrapie:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.4ADAM10, APP, GFAP, MAP2, PRNP, RPSA
2MP:00036317.1ADAM10, APP, CLU, GFAP, MAP2, PRND

Publications for Scrapie

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Articles related to Scrapie:

(show top 50)    (show all 682)
idTitleAuthorsYear
1
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. (26655166)
2016
2
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. (27211330)
2016
3
Prion protein scrapie and the normal cellular prion protein. (26645475)
2016
4
Correction: Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells. (25821952)
2015
5
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
6
EFSA assesses the impact of scrapie eradication policies. (25125401)
2014
7
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
8
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
9
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
10
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
11
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
12
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
13
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
14
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
15
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. (20085753)
2010
16
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
17
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
18
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
19
Scrapie genetics before the discovery of prions. (19707236)
2010
20
Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. (19751582)
2009
21
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
22
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
23
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. (19606066)
2009
24
Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep. (19577317)
2009
25
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
26
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
27
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
28
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
29
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. (18667494)
2008
30
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
31
Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility. (17361441)
2007
32
Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. (19164931)
2007
33
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
34
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
35
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
36
An evaluation of scrapie surveillance in the United States. (17482695)
2007
37
Effectiveness of capillary electrophoresis fluoroimmunoassay of blood PrpSc for evaluation of scrapie pathogenesis in sheep. (17823402)
2007
38
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
39
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
40
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
41
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)
2006
42
Scrapie and chronic wasting disease. (12733429)
2003
43
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
44
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
45
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
46
Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. (8372644)
1993
47
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
48
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991
49
Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)
1990
50

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

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Pathways related to Scrapie according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8APP, PRNP
29.7ADAM10, APP
39.7ADAM10, APP
49.3MT2A, TF

GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1recycling endosomeGO:00550379.2LDLRAP1, TF
2cell surfaceGO:00099869.2ADAM10, PRNP, TF

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:00082039.8APP, LDLRAP1
2extracellular matrix organizationGO:00301989.3ADAM10, APP, GFAP
3platelet degranulationGO:00025768.9CLU, TF

Sources for Scrapie

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet