MCID: SCR011
MIFTS: 45

Scrapie malady

Neuronal diseases category
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Summaries for Scrapie

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Wikipedia:65 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to variant creutzfeldt-jakob disease and prion disease. An important gene associated with Scrapie is PRNP (prion protein). The compounds guanidine hydrochloride and inulin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related mouse phenotypes are other and tumorigenesis.

Aliases & Classifications for Scrapie

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Scrapie, Aliases & Descriptions:

Name: Scrapie 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:5434
SNOMED-CT57 35103004
MeSH34 D012608

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1variant creutzfeldt-jakob disease30.7MSMB, PRNP
2prion disease30.6CLU, PRNP, MAPT
3memory impairment30.1MAPT, PRNP
4creutzfeldt-jakob disease30.0PRND, PRNP, MSMB, MAPT, CST3
5alzheimer's disease29.1CLU, PRND, PRNP, MAPT, CST3
6neuronitis10.5
7chronic wasting disease10.5
8kuru10.3
9neuroblastoma10.2
10hemorrhage, intracerebral10.2CST3, PRNP
11pharyngitis10.1
12tonsillitis10.1
13encephalitis10.1
14progressive supranuclear palsy10.1MAPT, PRNP
15lewy body dementia10.1PRNP, MAPT
16spinocerebellar ataxia10.1MAPT, PRNP
17multiple system atrophy10.1MAPT, PRNP
18myositis10.0PRNP, MAPT
19familial creutzfeldt-jakob disease10.0MSMB, PRNP, PRND
20toxic encephalopathy10.0MAPT, PRNP
21brain disease10.0MAPT, PRNP
22congenital heart disease10.0CST3, CLU
23acute myocardial infarction10.0CST3, CLU
24huntington's disease10.0MAPT, PRNP
25neuroaxonal dystrophy10.0
26louping ill10.0
27cerebritis10.0
28mastitis10.0
29mouth disease10.0
30peritonitis10.0
31retinitis10.0
32neurologic diseases10.0
33genetic prion diseases10.0
34endotheliitis10.0
35pick's disease10.0CLU, MAPT
36fibrosarcoma10.0CST3, CLU
37proteinuria9.9CST3, CLU
38infertility9.9MSMB, PRND, CLU
39atherosclerosis9.9CLU, PRNP, CST3
40cerebral amyloid angiopathy9.9CST3, MAPT, PRNP
41vascular dementia9.9PRNP, MAPT, CST3
42amyloid tumor9.9PRNP, MAPT, CST3
43amyotrophic lateral sclerosis type 149.9CST3, MAPT, PRNP
44cerebrovascular disease9.8CST3, MAPT, PRNP
45coronary artery anomaly9.8CLU, CST3
46malignant glioma9.7CLU, PRNP, MAPT
47ischemia9.7CST3, MAPT, CLU
48adenocarcinoma9.6CLU, MSMB, MAPT
49amyloidosis9.6CLU, PRNP, MAPT, CST3
50dementia9.6CST3, MAPT, PRNP, CLU

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Drug clinical trials:

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Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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MalaCards organs/tissues related to Scrapie:

32
Brain, Testes, Lymph node, Spleen, Retina, T cells, B cells, Kidney, Skin, Placenta, Tonsil, Medulla oblongata, Eye, Bone, Cortex, Cerebellum, Liver, Salivary gland, Adrenal gland, Endothelial, Pituitary, Neutrophil

Animal Models for Scrapie or affiliated genes

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MGI Mouse Phenotypes related to Scrapie:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.7MAPT, PRNP, CLU
2MP:00020068.6CST3, MAPT, MSMB
3MP:00053697.8CST3, MAPT, PRNP, CLU
4MP:00053877.6CLU, PRND, PRNP, MSMB, MAPT
5MP:00036317.5CLU, PRND, PRNP, MAPT, CST3

Publications for Scrapie

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Articles related to Scrapie:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
2
EFSA assesses the impact of scrapie eradication policies. (25125401)
2014
3
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
4
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
5
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
6
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
7
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
8
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
9
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
10
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
11
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. (20085753)
2010
12
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
13
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
14
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
15
Scrapie genetics before the discovery of prions. (19707236)
2010
16
Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. (19751582)
2009
17
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
18
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
19
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. (19606066)
2009
20
Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep. (19577317)
2009
21
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
22
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
23
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
24
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
25
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. (18667494)
2008
26
Detection of prion infectivity in fat tissues of scrapie-infected mice. (19057664)
2008
27
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
28
Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility. (17361441)
2007
29
Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. (19164931)
2007
30
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
31
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
32
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
33
An evaluation of scrapie surveillance in the United States. (17482695)
2007
34
Effectiveness of capillary electrophoresis fluoroimmunoassay of blood PrpSc for evaluation of scrapie pathogenesis in sheep. (17823402)
2007
35
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
36
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
37
Infectivity of scrapie prion protein (PrPSc) following in vitro digestion with bovine gastrointestinal microbiota. (17542960)
2007
38
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
39
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
40
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
41
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)
2006
42
Scrapie and chronic wasting disease. (12733429)
2003
43
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
44
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
45
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
46
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
47
Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. (8372644)
1993
48
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
49
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991
50
Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)
1990

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Expression patterns in normal tissues for genes affiliated with Scrapie

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Pathways for genes affiliated with Scrapie

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Compounds for genes affiliated with Scrapie

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Compounds related to Scrapie according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride449.9MSMB, PRNP
2inulin449.8CST3, CLU
3kininogen449.7CST3, CLU
4formate449.6MAPT, PRNP
5guanidine44 24 1111.6MAPT, PRNP
6homocysteine44 2410.6CLU, CST3
7sodium dodecylsulfate449.5PRNP, MAPT
8vitamin b12449.5MAPT, CST3
9silver449.4CST3, MAPT
10colchicine44 61 2 28 1113.3MAPT, CLU
11agarose449.3CLU, PRNP, CST3
12polysaccharide449.3CST3, PRNP, CLU
13kainate44 2810.3MAPT, CLU
14superoxide44 2410.3CST3, PRNP, CLU
15formaldehyde44 2410.2MAPT, PRNP
16sialic acid449.2CLU, CST3
17cholesterol44 28 24 1112.2CLU, PRNP, CST3
18valine449.2PRND, PRNP, MAPT
19urea44 24 1111.1CST3, MAPT
20steroid449.1CST3, MSMB, CLU
21aspartate449.1PRNP, MAPT, CST3
22paraffin449.0CLU, PRNP, MAPT
23proline449.0MAPT, PRNP, CLU
24heparin44 28 24 1112.0MAPT, PRNP, CLU
25arginine449.0CST3, MAPT, PRNP
26h2o2449.0MAPT, PRNP, CLU
27folate448.9CST3, MAPT, CLU
28n acetylcysteine448.9CLU, MAPT, CST3
29threonine448.9CST3, MAPT, PRNP
30lactate448.9CLU, MAPT, CST3
31testosterone44 61 24 1111.8CLU, MSMB, MAPT
32zinc44 249.8CLU, PRNP, MAPT
33alanine448.8CST3, MAPT, PRNP
34glutamate448.7CLU, PRNP, MAPT
35docetaxel44 50 61 1111.7CLU, MAPT
36methionine448.7CST3, MAPT, PRNP, PRND
37calcium44 50 24 1111.5CLU, PRNP, MSMB, CST3
38serine448.5CLU, PRNP, MAPT, CST3
39cysteine448.4CST3, MAPT, MSMB, CLU

GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312259.6PRNP, PRND

Molecular functions related to Scrapie according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:0080179.2MAPT, PRNP

Products for genes affiliated with Scrapie

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Sources for Scrapie

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet