Aliases & Classifications for Scrapie

About this section

Aliases & Descriptions for Scrapie:

Name: Scrapie 11 13 48 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:5434
SNOMED-CT60 35103004
MeSH37 D012608

Summaries for Scrapie

About this section
Wikipedia:69 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to creutzfeldt-jakob disease and encephalopathy. An important gene associated with Scrapie is SCRG1 (Stimulator Of Chondrogenesis 1), and among its related pathways are Glypican 1 network and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and spleen, and related mouse phenotypes are behavior/neurological and growth/size/body region.

Related Diseases for Scrapie

About this section

Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1creutzfeldt-jakob disease10.8
2encephalopathy10.7
3familial mediterranean fever type 210.6PRND, PRNP
4diabetes insipidus, neurohypophyseal10.5MSMB, PRNP
5choroid plexus cancer10.5PRNP, SPRN
6prion disease10.4
7alagille syndrome10.3MSMB, PRND, PRNP
8chronic wasting disease10.3
9neuronitis10.3
10huntington disease-like 110.3APP, MSMB, PRNP
11gastric small cell carcinoma10.3GFAP, TF
12hemiplegia alterans10.3CHAT, GFAP
13chiari malformation type 410.2GFAP, MAP2
14gemistocytic astrocytoma10.2APP, PRNP, TF
15intracystic papillary adenoma10.2GFAP, MAP2
16chronic gonorrhea of cervix10.2APP, SPRN
17congenital hypogammaglobulinemia10.1GFAP, MAP2
18large intestine lipoma10.1GFAP, MAP2
19kuru10.1
20meier-gorlin syndrome 510.0APP, CHAT
21neuroblastoma10.0
22mixed epithelial stromal tumour10.0GFAP, MAP2
23ovarian mucinous cystadenocarcinoma10.0GFAP, MAP2, PRNP
24alzheimer disease9.9
25tonsillitis9.9
26pharyngitis9.9
27encephalitis9.9
28angiomyolipoma9.8APP, CHAT, GFAP, PRNP
29xfe progeroid syndrome9.8CLU, TF
30adenomyoma of uterine corpus9.8GFAP, MAP2
31chronic intestinal vascular insufficiency9.8APP, CHAT, GFAP, PRNP
32louping ill9.8
33mastitis9.8
34neuroaxonal dystrophy9.8
35cerebritis9.8
36retinitis9.8
37mouth disease9.8
38peritonitis9.8
39genetic prion diseases9.8
40endotheliitis9.8
41spinal muscular atrophy, lower extremity-predominant, 2, ad9.4CLU, TF
42long qt syndrome 59.2APP, CHAT, GFAP, MAP2, PRNP
43prion disease with protracted course8.7CLU, MSMB, PRND, PRNP, RPSA, SPRN
44breast epithelioid hemangioma8.5ADAM10, MAP2, MSMB, PRND, PRNP, SPRN
45hypersensitivity syndrome, carbamazepine-induced7.9ADAM10, APP, CHAT, CLU, GFAP, MAP2
46extrahepatic bile duct adenoma5.6ADAM10, APP, CHAT, CLU, GFAP, MAP2

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

About this section

Drugs & Therapeutics for Scrapie

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at HomeRecruitingNCT02346305

Search NIH Clinical Center for Scrapie


Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

About this section

Anatomical Context for Scrapie

About this section

MalaCards organs/tissues related to Scrapie:

34
Brain, Testes, Spleen, Lymph node, Retina, Placenta, T cells

Animal Models for Scrapie or affiliated genes

About this section

MGI Mouse Phenotypes related to Scrapie:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053866.9APP, CHAT, CLU, GFAP, MAP2, PRND
2MP:00053786.4ADAM10, APP, CHAT, GFAP, MAP2, PRNP
3MP:00036316.4ADAM10, APP, CHAT, CLU, GFAP, MAP2

Publications for Scrapie

About this section

Articles related to Scrapie:

(show top 50)    (show all 694)
idTitleAuthorsYear
1
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. (26655166)
2016
2
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. (27211330)
2016
3
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. (27317933)
2016
4
Prion protein scrapie and the normal cellular prion protein. (26645475)
2016
5
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie. (27385410)
2016
6
Transmission of atypical scrapie to homozygous ARQ sheep. (27320968)
2016
7
Correction: Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells. (25821952)
2015
8
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
9
Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. (23651659)
2013
10
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
11
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
12
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
13
Direct evidence of generation and accumulation of I^-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for I^-form prion protein. (22356913)
2012
14
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
15
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
16
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
17
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
18
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
19
Sheep with scrapie and mastitis transmit infectious prions through the milk. (21084475)
2011
20
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
21
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
22
Scrapie genetics before the discovery of prions. (19707236)
2010
23
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
24
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
25
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
26
Olfactory system involvement in natural scrapie disease. (19158242)
2009
27
Scrapie pathogenesis: the role of complement C1q in scrapie agent uptake by conventional dendritic cells. (19155476)
2009
28
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
29
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
30
In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie. (19008409)
2008
31
Observing fibrillar assemblies on scrapie-infected cells. (18175144)
2008
32
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
33
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
34
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
35
An evaluation of scrapie surveillance in the United States. (17482695)
2007
36
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
37
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
38
Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters. (17181988)
2007
39
Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles. (17267596)
2007
40
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
41
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
42
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
43
Scrapie and chronic wasting disease. (12733429)
2003
44
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
45
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
46
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
47
Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform. (8643624)
1996
48
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
49
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
50
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991

Variations for Scrapie

About this section

Expression for genes affiliated with Scrapie

About this section
Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

About this section

GO Terms for genes affiliated with Scrapie

About this section

Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1astrocyte projectionGO:009744910.2APP, GFAP
2anchored component of membraneGO:003122510.0PRND, PRNP, SPRN
3cell surfaceGO:00099868.1ADAM10, APP, CLU, PRNP, TF
4Golgi apparatusGO:00057948.0ADAM10, APP, CLU, PRNP, SCRG1
5cytoplasmGO:00057376.1ADAM10, APP, CHAT, CLU, GFAP, MAP2

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular copper ion homeostasisGO:00068789.2APP, MT2A, PRND, PRNP
2platelet degranulationGO:00025768.5APP, CLU, TF

Sources for Scrapie

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet