MCID: SCR011
MIFTS: 38

Scrapie malady

Category: Neuronal diseases

Aliases & Classifications for Scrapie

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Aliases & Descriptions for Scrapie:

Name: Scrapie 11 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:5434
SNOMED-CT62 35103004
MeSH39 D012608

Summaries for Scrapie

About this section
MalaCards based summary: Scrapie is related to creutzfeldt-jakob disease and encephalopathy. An important gene associated with Scrapie is SCRG1 (Stimulator Of Chondrogenesis 1), and among its related pathways are Glypican 1 network and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and spleen, and related mouse phenotypes are immune system and behavior/neurological.

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1creutzfeldt-jakob disease11.2
2encephalopathy10.5
3prion disease10.3
4adult choroid plexus cancer10.2PRNP, SPRN
5deafness, autosomal recessive 10110.2GFAP, PRNP
6chronic wasting disease10.2
7neuronitis10.2
8alagille syndrome10.2MSMB, PRND, PRNP
9homocystinuria caused by cystathionine beta-synthase deficiency10.2APOE, PRNP
10huntington disease-like 110.2APP, MSMB, PRNP
11charcot-marie-tooth disease10.2APP, GFAP, PRNP
12amelogenesis imperfecta, type iia310.1ADAM10, APP
13children's interstitial lung disease10.1GFAP, MAP2
14pars planitis10.1APOE, RPSA
15encephalitozoonosis10.1APOE, APP
16vulvar benign neoplasm10.1GFAP, MAP2
17adenofibroma10.1GFAP, MAP2
18polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.1APOE, APP, PRNP
19hemorrhagic proctocolitis10.1GFAP, MAP2
20contagious pustular dermatitis10.1APOE, APP, PRNP
21coenzyme q10 deficiency, primary, 110.1APOE, APP, PRNP
22bone dysplasia azouz type10.1APOE, APP, GFAP
23alzheimer disease 19, late onset10.1APOE, CLU
24hard palate cancer10.0APOE, APP, PRNP
25ichthyosis lamellar 210.0APOE, APP, GFAP
26ovarian mucinous adenocarcinoma10.0GFAP, MAP2, PRNP
27bronchiolitis obliterans10.0GFAP, MAP2
28fancf-related fanconi anemia10.0APOE, MSMB, PRND, PRNP
29eumycotic mycetoma10.0APOE, APP, PRNP
30brain stem astrocytic neoplasm10.0GFAP, MAP2
31substance-induced psychosis10.0APOE, APP, GFAP, PRNP
32epithelioid type angiomyolipoma10.0APOE, APP, GFAP, PRNP
33kuru9.9
34calcific tendinitis9.9GFAP, MAP2
35xfe progeroid syndrome9.9CLU, TF
36neuroblastoma9.9
37long qt syndrome 59.8APP, GFAP, MAP2, PRNP
38alzheimer disease9.8
39tonsillitis9.8
40pharyngitis9.8
41encephalitis9.8
42prion disease with protracted course9.7APOE, MSMB, PRND, PRNP, RPSA, SPRN
43louping ill9.6
44mastitis9.6
45neuroaxonal dystrophy9.6
46cerebritis9.6
47retinitis9.6
48mouth disease9.6
49peritonitis9.6
50genetic prion diseases9.6

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms & Phenotypes for Scrapie

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MGI Mouse Phenotypes related to Scrapie according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2ADAM10, APOE, APP, CLU, GFAP, MSMB
2MP:00053868.2APOE, APP, CLU, GFAP, MAP2, PRND
3MP:00053787.1ADAM10, APOE, APP, GFAP, MAP2, PRNP
4MP:00036316.8ADAM10, APOE, APP, CLU, GFAP, MAP2

Drugs & Therapeutics for Scrapie

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Drugs for Scrapie (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EthanolapprovedPhase 3213764-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
2
MethotrexateapprovedPhase 215511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
3
Folic Acidapproved, nutraceutical, vet_approvedPhase 2439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
4
leucovorinapproved, NutraceuticalPhase 2323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
5Vitamin B ComplexPhase 24337
6Immunosuppressive AgentsPhase 213086
7Nucleic Acid Synthesis InhibitorsPhase 24962
8Folic Acid AntagonistsPhase 22257
9AntimetabolitesPhase 212054
10Antirheumatic AgentsPhase 210956
11Antimetabolites, AntineoplasticPhase 27361
12Dermatologic AgentsPhase 25806
13FolateNutraceuticalPhase 24392
14Vitamin B9NutraceuticalPhase 24392
15Central Nervous System Depressants13403
16Anesthetics9596

Interventional clinical trials:

idNameStatusNCT IDPhase
1Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep ApneaRecruitingNCT02989181Phase 3
2Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid ArthritisRecruitingNCT02638948Phase 2
3Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at HomeRecruitingNCT02346305
4Regional Versus General Anesthesia for Promoting Independence After Hip FractureRecruitingNCT02507505

Search NIH Clinical Center for Scrapie


Cochrane evidence based reviews: scrapie

Genetic Tests for Scrapie

About this section

Anatomical Context for Scrapie

About this section

MalaCards organs/tissues related to Scrapie:

36
Brain, Testes, Spleen, Lymph node, Retina, Placenta, T cells

Publications for Scrapie

About this section

Articles related to Scrapie:

(show top 50)    (show all 704)
idTitleAuthorsYear
1
Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep. (27936597)
2017
2
Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells. (28063003)
2017
3
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus. (27751198)
2017
4
Identification of the first case of atypical scrapie in Japan. (27616556)
2016
5
The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein. (27317933)
2016
6
Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health. (27928518)
2016
7
Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia. (26807844)
2016
8
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. (27921253)
2016
9
Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases. (27211330)
2016
10
Controlling scrapie and bovine spongiform encephalopathy in goats. (26868240)
2016
11
Altered trafficking of abnormal prion protein in atypical scrapie: Prion protein accumulation in oligodendroglial inner mesaxons. (26750308)
2016
12
Prion protein scrapie and the normal cellular prion protein. (26645475)
2016
13
Temporal Resolution of Misfolded Prion Protein Transport, Accumulation, Glial Activation, and Neuronal Death in the Retinas of Mice Inoculated with Scrapie. (27521336)
2016
14
Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds. (26755614)
2016
15
MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15. (27826142)
2016
16
Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs. (27417309)
2016
17
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells. (27537339)
2016
18
Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats. (27005313)
2016
19
Evidence of scrapie transmission to sheep via goat milk. (27640200)
2016
20
Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. (27991723)
2016
21
Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. (27033930)
2016
22
Isolation of a Defective Prion Mutant from Natural Scrapie. (27880822)
2016
23
Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains. (26936223)
2016
24
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. (26847623)
2016
25
Phosphorylated human tau associates with mouse prion protein amyloid in scrapie-infected mice but does not increase progression of clinical disease. (27463540)
2016
26
Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie. (27385410)
2016
27
Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic. (27215403)
2016
28
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions. (27259989)
2016
29
Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion. (26653410)
2016
30
Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice. (27221113)
2016
31
Goat K222-PrP(C) polymorphic variant does not provide resistance to atypical scrapie in transgenic mice. (27659200)
2016
32
Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model. (26655166)
2016
33
Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain. (26976340)
2016
34
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models. (26887380)
2016
35
Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. (27021907)
2016
36
CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection. (26773845)
2016
37
Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals. (27590859)
2016
38
Transmission of atypical scrapie to homozygous ARQ sheep. (27320968)
2016
39
Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease. (27109462)
2016
40
In this issue - December 2016: Chemical immobilisation of free-range cattlea88A^a88Dairy cow progesterone assaya88A^a88Atypical scrapie in sheepa88A^a88Antibiotic resistance in healthy dogsa88A^a88Contrast CT in dermoid sinusesa88A^ Pneumorrhachis in a doga88A^a88Dorsal perineal artery for axial pattern flap surgery in a cata88A^a88Inducing emesis in dogs. (27891596)
2016
41
Atypical scrapie in Australia. (27807855)
2016
42
A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. (27216989)
2016
43
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. (27393736)
2016
44
Evaluation of efficacy of prion reduction filters using blood from an endogenously infected 263K scrapie hamster model. (26033029)
2015
45
Mechanism of Scrapie Prion Precipitation with Phosphotungstate Anions. (25695325)
2015
46
Synthetic Scrapie Infectivity: Interaction between Recombinant PrP and Scrapie Brain-Derived RNA. (25585171)
2015
47
Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice. (26396245)
2015
48
Correction: A Bovine Cell Line That Can Be Infected by Natural Sheep Scrapie Prions. (25806533)
2015
49
PrP genotype frequencies and risk evaluation for scrapie in dairy sheep breeds from southern Italy. (26549664)
2015
50
Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time. (25928902)
2015

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

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GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:003122510.5PRND, PRNP, SPRN
2dendritic shaftGO:004319810.2APP, MAP2
3blood microparticleGO:00725629.6APOE, CLU, TF
4postsynaptic densityGO:00140699.1ADAM10, MAP2, PRNP
5endoplasmic reticulum lumenGO:00057888.9ADAM10, APOE, APP, TF
6cell surfaceGO:00099868.9ADAM10, APP, CLU, PRNP, TF
7Golgi apparatusGO:00057948.7ADAM10, APOE, APP, CLU, PRNP, SCRG1
8extracellular spaceGO:00056158.0ADAM10, APOE, APP, CLU, MSMB, SCRG1
9extracellular regionGO:00055768.0APOE, APP, CLU, MSMB, PRND, SCRG1

Biological processes related to Scrapie according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuron deathGO:190121610.5CLU, PRNP
2negative regulation of long-term synaptic potentiationGO:190027210.4APOE, PRNP
3negative regulation of beta-amyloid formationGO:190243010.3APOE, CLU
4nitric oxide mediated signal transductionGO:000726310.2APOE, MT2A
5protein importGO:001703810.2APOE, CLU
6regulation of beta-amyloid clearanceGO:190022110.2APOE, CLU
7positive regulation of receptor-mediated endocytosisGO:004826010.0CLU, TF
8cellular copper ion homeostasisGO:00068789.8APP, MT2A, PRND, PRNP
9reverse cholesterol transportGO:00436919.6APOE, CLU
10response to oxidative stressGO:00069799.6APOE, APP, PRNP
11platelet degranulationGO:00025769.5APP, CLU, TF
12cellular protein metabolic processGO:00442678.8ADAM10, APOE, APP, TF
13post-translational protein modificationGO:00436878.7ADAM10, APOE, APP, TF

Molecular functions related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-amyloid bindingGO:00015409.7APOE, CLU, PRNP
2low-density lipoprotein particle receptor bindingGO:00507509.6APOE, CLU

Sources for Scrapie

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2CDC
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15ExPASy
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67Tumor Gene Family of Databases
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69UMLS via Orphanet