Aliases & Classifications for Scrapie

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Scrapie, Aliases & Descriptions:

Name: Scrapie 9 11 43 60


External Ids:

Disease Ontology9 DOID:5434
SNOMED-CT55 35103004
MeSH33 D012608

Summaries for Scrapie

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Wikipedia:63 Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one... more...

MalaCards based summary: Scrapie is related to creutzfeldt-jakob disease and prion disease. An important gene associated with Scrapie is PRNP (prion protein). The compounds guanidine hydrochloride and inulin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related mouse phenotypes are other and tumorigenesis.

Related Diseases for Scrapie

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Diseases related to Scrapie via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1creutzfeldt-jakob disease31.1MSMB, PRNP
2prion disease30.6CLU, PRNP, MAPT
3alzheimer disease29.3CLU, PRND, PRNP, MAPT, CST3
4chronic wasting disease10.5
5neuronitis10.5
6kuru10.3
7neuroblastoma10.2
8hemorrhage, intracerebral10.2CST3, PRNP
9pharyngitis10.1
10tonsillitis10.1
11encephalitis10.1
12supranuclear palsy, progressive10.1MAPT, PRNP
13dementia, lewy body10.1PRNP, MAPT
14spinocerebellar ataxia10.1MAPT, PRNP
15multiple system atrophy10.0MAPT, PRNP
16myositis10.0PRNP, MAPT
17familial creutzfeldt-jakob disease10.0MSMB, PRNP, PRND
18toxic encephalopathy10.0MAPT, PRNP
19brain disease10.0MAPT, PRNP
20congenital heart disease10.0CST3, CLU
21neuroaxonal dystrophy10.0
22louping ill10.0
23cerebritis10.0
24mastitis10.0
25mouth disease10.0
26peritonitis10.0
27retinitis10.0
28neurologic diseases10.0
29genetic prion diseases10.0
30endotheliitis10.0
31acute myocardial infarction10.0CST3, CLU
32huntington disease10.0MAPT, PRNP
33fibrosarcoma10.0CST3, CLU
34pick disease10.0CLU, MAPT
35proteinuria9.9CST3, CLU
36infertility9.9MSMB, PRND, CLU
37atherosclerosis9.9CLU, PRNP, CST3
38cerebral amyloid angiopathy9.9CST3, MAPT, PRNP
39vascular dementia9.9PRNP, MAPT, CST3
40amyotrophic lateral sclerosis 19.8CST3, MAPT, PRNP
41stroke, ischemic9.8CST3, MAPT, PRNP
42coronary artery disease9.8CLU, CST3
43malignant glioma9.7CLU, PRNP, MAPT
44ischemia9.7CST3, MAPT, CLU
45adenocarcinoma9.6CLU, MSMB, MAPT
46amyloidosis9.6CLU, PRNP, MAPT, CST3
47dementia9.6CST3, MAPT, PRNP, CLU

Graphical network of the top 20 diseases related to Scrapie:



Diseases related to scrapie

Symptoms for Scrapie

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Drugs & Therapeutics for Scrapie

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Drug clinical trials:

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Genetic Tests for Scrapie

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Anatomical Context for Scrapie

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MalaCards organs/tissues related to Scrapie:

31
Brain, Testes, Lymph node, Spleen, Retina, Placenta, T cells, B cells, Kidney, Skin, Tonsil, Medulla oblongata, Eye, Bone, Cortex, Cerebellum, Liver, Salivary gland, Adrenal gland, Endothelial, Pituitary, Neutrophil

Animal Models for Scrapie or affiliated genes

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MGI Mouse Phenotypes related to Scrapie:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.7MAPT, PRNP, CLU
2MP:00020068.6CST3, MAPT, MSMB
3MP:00053697.8CST3, MAPT, PRNP, CLU
4MP:00053877.6CLU, PRND, PRNP, MSMB, MAPT
5MP:00036317.5CLU, PRND, PRNP, MAPT, CST3

Publications for Scrapie

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Articles related to Scrapie:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Correction: Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells. (25821952)
2015
2
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein. (25248142)
2014
3
EFSA assesses the impact of scrapie eradication policies. (25125401)
2014
4
Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain. (22272295)
2012
5
Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35. (22787236)
2012
6
Disease phenotype in sheep after infection with cloned murine scrapie strains. (22421207)
2012
7
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. (21980292)
2011
8
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. (21909267)
2011
9
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie. (20093056)
2011
10
Detection of prions in the faeces of sheep naturally infected with classical scrapie. (21592355)
2011
11
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. (21539311)
2011
12
Differentiating blood samples from scrapie infected and non-infected hamsters by detecting disease-associated prion proteins using Multimer Detection System. (20085753)
2010
13
Surveillance and simulation of bovine spongiform encephalopathy and scrapie in small ruminants in Switzerland. (20398417)
2010
14
Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. (19968641)
2010
15
The distribution of four trace elements (Fe, Mn, Cu, Zn) in forage and the relation to scrapie in Iceland. (20492671)
2010
16
Scrapie genetics before the discovery of prions. (19707236)
2010
17
Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. (19751582)
2009
18
Prevalence of sheep infected with classical scrapie in Great Britain, 1993-2007. (19351431)
2009
19
Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival. (19212437)
2009
20
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases. (19606066)
2009
21
Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep. (19577317)
2009
22
Identification of proteins co-purifying with scrapie infectivity. (19367687)
2009
23
Neuroanatomical distribution of abnormal prion protein in naturally occurring atypical scrapie cases in Great Britain. (18797889)
2008
24
Excretion of BSE and scrapie prions in stools from murine models. (18395370)
2008
25
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces. (18089760)
2008
26
Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. (18667494)
2008
27
Detection of prion infectivity in fat tissues of scrapie-infected mice. (19057664)
2008
28
Treatment of scrapie pathogen 263K with tetracycline partially abolishes protease-resistant activity in vitro and reduces infectivity in vivo. (17672209)
2007
29
Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility. (17361441)
2007
30
Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. (19164931)
2007
31
Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep. (17848990)
2007
32
Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. (17524497)
2007
33
Characterization of scrapie-infected and normal hamster blood as an experimental model for TSE-infected human blood. (17486885)
2007
34
An evaluation of scrapie surveillance in the United States. (17482695)
2007
35
Effectiveness of capillary electrophoresis fluoroimmunoassay of blood PrpSc for evaluation of scrapie pathogenesis in sheep. (17823402)
2007
36
Prion protein expression differences in microglia and astroglia influence scrapie-induced neurodegeneration in the retina and brain of transgenic mice. (17652390)
2007
37
Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. (17728226)
2007
38
PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie. (17177611)
2006
39
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. (16724107)
2006
40
Assessment of calcium-binding proteins (Parvalbumin and Calbindin D-28K) and perineuronal nets in normal and scrapie-affected adult sheep brains. (16828173)
2006
41
Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)
2006
42
Scrapie and chronic wasting disease. (12733429)
2003
43
Ultrastructural changes in the optic nerves of rodents with experimental Creutzfeldt-Jakob Disease (CJD), Gerstmann-StrAoussler-Scheinker disease (GSS) or scrapie. (12921728)
2003
44
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. (10773427)
2000
45
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. (8962161)
1996
46
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)
1993
47
Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. (8372644)
1993
48
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
49
Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. (1681473)
1991
50
Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)
1990

Variations for Scrapie

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Expression for genes affiliated with Scrapie

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Search GEO for disease gene expression data for Scrapie.

Pathways for genes affiliated with Scrapie

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Compounds for genes affiliated with Scrapie

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Compounds related to Scrapie according to GeneCards Suite gene sharing:

(show all 39)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride439.9PRNP, MSMB
2inulin439.8CST3, CLU
3kininogen439.7CLU, CST3
4formate439.6PRNP, MAPT
5guanidine43 24 1211.6PRNP, MAPT
6homocysteine43 2410.5CLU, CST3
7sodium dodecylsulfate439.5PRNP, MAPT
8vitamin b12439.5MAPT, CST3
9silver439.4MAPT, CST3
10colchicine43 59 2 28 1213.3CLU, MAPT
11agarose439.3PRNP, CLU, CST3
12polysaccharide439.3CLU, PRNP, CST3
13kainate43 2810.3CLU, MAPT
14superoxide43 2410.3CLU, CST3, PRNP
15formaldehyde43 2410.2MAPT, PRNP
16cholesterol43 28 24 1212.2PRNP, CST3, CLU
17valine439.2MAPT, PRNP, PRND
18urea43 24 1211.1MAPT, CST3
19steroid439.1MSMB, CLU, CST3
20aspartate439.1PRNP, CST3, MAPT
21sialic acid439.0CLU, CST3
22paraffin439.0CLU, PRNP, MAPT
23proline439.0MAPT, PRNP, CLU
24heparin43 28 24 1212.0MAPT, PRNP, CLU
25arginine439.0PRNP, CST3, MAPT
26h2o2439.0PRNP, MAPT, CLU
27docetaxel43 49 59 1211.9MAPT, CLU
28folate438.9MAPT, CST3, CLU
29n acetylcysteine438.9CLU, MAPT, CST3
30threonine438.9PRNP, MAPT, CST3
31lactate438.9CST3, CLU, MAPT
32zinc43 249.8PRNP, CLU, MAPT
33testosterone43 59 24 1211.8MSMB, CLU, MAPT
34alanine438.8MAPT, CST3, PRNP
35glutamate438.7CLU, PRNP, MAPT
36methionine438.7PRND, PRNP, MAPT, CST3
37calcium43 49 24 1211.5CST3, MSMB, PRNP, CLU
38serine438.5CLU, PRNP, MAPT, CST3
39cysteine438.4CLU, MSMB, MAPT, CST3

GO Terms for genes affiliated with Scrapie

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Cellular components related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:00312259.6PRNP, PRND

Molecular functions related to Scrapie according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:00080179.2MAPT, PRNP

Products for genes affiliated with Scrapie

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Sources for Scrapie

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