Scrapie malady

Wikipedia: Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats. It is one...⁴⁴ more...

MalaCards: Scrapie, also known as scrapie (disorder), is related to bovine spongiform encephalopathy and alzheimer's disease. An important gene associated with Scrapie is SCRG1 (stimulator of chondrogenesis 1), and among its related pathways are Alzheimers Disease Pathway and Neuroscience. The compounds gelfoam and quinolinic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, adrenal gland and b cells, and related mouse phenotypes are nervous system and other.

Aliases & Descriptions:

scrapie 6 8 32 43 scrapie (disorder) 6

Diseases related to scrapie by text searches and GeneDecks gene sharing:

(show top 50)    (show all 133)

id	Related Disease	Score	Top Affiliating Genes
1	bovine spongiform encephalopathy	30.4	PRND, PRNP
2	alzheimer's disease	29.4	CLU, APOE, APP, MAPT, PRNP
3	prion disease	27.4	CLU, APOE, APP, MAPT, NOS1, GFAP
4	immunodeficiency	22.7	RABEPK, BLVRB, CHST8, ITIH4, APOE, APP
5	neuronitis	22.3	BLVRB, CLU, SCN2A, SCRG1, MT2A, ITIH4
6	wernicke encephalopathy	13.4	MAPT, GFAP, PRNP
7	cerebral neuroblastoma	13.4	ENO2, GFAP
8	pineal gland cancer	13.2	ENO2, GFAP
9	gerstmann-straussler-scheinker disease	13.2	APP, PRNP
10	primary progressive aphasia	13.1	APP, MAPT, PRNP
11	semantic dementia	13.1	APOE, MAPT
12	familial creutzfeldt-jakob disease	13.1	MSMB, APOE, PRND, PRNP
13	persistent vegetative state	13.1	APOE, ENO2
14	variant creutzfeldt-jakob disease	13.0	APOE, ENO2, PRND, PRNP
15	supratentorial neoplasm	13.0	ENO2, PRL
16	familial idiopathic basal ganglia calcification	13.0	APP, MAPT
17	normal pressure hydrocephalus	13.0	APOE, MAPT, GFAP
18	cerebral atrophy	13.0	APOE, MAPT, GFAP
19	hereditary cerebral hemorrhage with amyloidosis	12.9	APP, GFAP, CST3
20	achalasia	12.9	BLVRB, ENO2, NOS1
21	cystitis	12.9	ITIH4, ENO2, NOS1, CST3
22	progressive supranuclear palsy	12.9	APOE, MAPT, GFAP, PVALB
23	chronic wasting disease	12.9	ERC1, RPSA, PRNP
24	adenoiditis	12.8	CLU, MSMB, ENO2, RPSA, GFAP
25	impotence	12.8	BLVRB, NOS1, PRL
26	schizophreniform disorder	12.8	APOE, PRL
27	early-onset familial alzheimer disease	12.8	APP, MAPT
28	cerebral amyloid angiopathy	12.8	APOE, APP
29	multiple system atrophy	12.8	APOE, MAPT, GFAP, PVALB, PRNP
30	motor neuron disease	12.8	APOE, MAPT, NOS1, PVALB
31	epilepsy syndrome	12.7	BLVRB, CLU, NOS1, GFAP, PVALB, PRNP
32	intractable epilepsy	12.7	BLVRB, SCN2A, GFAP
33	cognitive disease	12.7	APOE, APP, MAPT
34	ganglioglioma	12.7	ENO2, GFAP, PVALB
35	alzheimer disease type 2	12.7	APOE, APP, MAPT
36	hirschsprung's disease	12.7	BLVRB, ENO2, NOS1, GFAP
37	aicardi-goutieres syndrome	12.6	ITIH4, APP, ENO2, MAPT, PRNP
38	temporal lobe epilepsy	12.6	GFAP, PVALB, PRNP
39	alzheimer disease type 1	12.6	APOE, APP, MAPT, CST3
40	central nervous system disease	12.6	APP, MAPT, GFAP
41	lewy body dementia	12.6	APOE, APP, MAPT
42	aphasia	12.6	APOE, APP, MAPT, PRNP
43	convulsions	12.6	BLVRB, SCN2A, APOE, ENO2
44	tauopathy	12.6	APOE, APP, MAPT, PRNP
45	inclusion body myositis	12.6	APP, NOS1, PRNP, MYL4
46	huntington's disease	12.5	BLVRB, APP, MAPT, NOS1, PRNP
47	pick's disease	12.5	CLU, APOE, APP, MAPT
48	cadasil	12.5	APOE, ENO2, MAPT, CAST, PVALB, PRNP
49	amyloid tumor	12.5	APOE, APP, MAPT, PRNP, CST3
50	beriberi	12.5	APOE, APP, GFAP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to scrapie:

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MGI Mouse Phenotypes related to scrapie:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	8.6	CST3, PRL, PRND, PVALB, RNF111, NOS1
2	other phenotype	MP:0005395	8.4	CLU, PRNP, NOS1, MAPT, APP, APOE
3	normal phenotype	MP:0002873	7.5	NOS1, GFAP, PVALB, PRNP, ERC1, MAFF
4	muscle phenotype	MP:0005369	7.3	CST3, PRNP, PVALB, GFAP, NOS1, PLCB4
5	immune system phenotype	MP:0005387	6.7	MAPT, NOS1, GFAP, PRND, PRL, ENTPD5
6	behavior/neurological phenotype	MP:0005386	6.0	GFAP, PVALB, PRND, PRL, PRNP, NOS1

Articles related to scrapie:

(show top 50)    (show all 80)

id	Title	Authors	Year	Affiliating Genes
1	Strain specific resistance to murine scrapie associat ed with a naturally occurring human prion protein polymorphism at residue 171. (21980292)	Striebel J.F.... Chesebro B.	2011	PRNP
2	A single step multiplex immunofluorometric assay for differential diagnosis of BSE and scrapie. (20214905)	Tang Y.... Sauer M.J.	2010	PRNP
3	Changes of tau profiles in brains of the hamsters inf ected with scrapie strains 263 K or 139 A possibly associated with the alterati on of phosphate kinases. (20356412)	Wang G.R.... Dong X.P.	2010	MAPT
4	Co-existence of scrapie prion protein types 1 and 2 i n sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-typ e characteristics. (19734292)	Cali I.... Gambetti P.	2009	PRNP
5	Prion infection of mice transgenic for human APPSwe: increased accumulation of cortical formic acid extractable Abeta(1-42) and rapid scrapie disease development. (18662767)	Baier M.... Schliebs R.	2008	APP
6	The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation. (18198392)	Green K.M.... Telling G.C.	2008	PRNP
7	Diversity in neuroanatomical distribution of abnormal prion protein in atypical scrapie. (17559305)	Nentwig A.... Seuberlich T.	2007	PRNP
8	Mouse-adapted scrapie infection of SN56 cells: greate r efficiency with microsome-associated versus purified PrP-res. (16474119)	Baron G.S.... Caughey B.	2006	PRNP
9	Scrapie infectivity is quickly cleared in tissues of orally-infected farmed fish. (16776828)	Ingrosso L.... Pocchiari M.	2006	PRND
10	The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines. (15869502)	Pimpinelli F.... Maridonneau-Parini I.	2005	FLOT1
11	Analysis of mammalian scrapie protein by novel monoclonal antibodies recognizing distinct prion protein glycoforms: an immunoblot and immunohistochemical study at the light and electron microscopic levels. (15763182)	Matucci A.... Tridente G.	2005	PRNP
12	Glycosylation-related gene expression in prion diseases: PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation. (15632154)	Barret A.... Gallet P.F.	2005	CHST8
13	Pathology and pathogenesis of bovine spongiform encep halopathy and scrapie. (15148988)	Jeffrey M.... GonzA!lez L.	2004	PRNP
14	Comparison study on clinical and neuropathological characteristics of hamsters inoculated with scrapie strain 263K in different challenging pathways. (15202866)	Zhang J.... Dong X.P.	2004	ENO2, GFAP
15	Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use. (15166274)	Caplazi P.A.... Baszler T.V.	2004	PRNP
16	Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease. (12586339)	Peoc'h K.... Lehmann S.	2003	PRND
17	The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells. (12634848)	Leucht C.... Weiss S.	2003	RPSA
18	Sub-cellular pathology of scrapie: coated pits are in creased in PrP codon 136 alanine homozygous scrapie-affected sheep. (12669239)	Ersdal C.... Jeffrey M.	2003	PRNP
19	Susceptibility of transgenic mice expressing chimeric sheep, bovine and human PrP genes to sheep scrapie. (12679564)	Gombojav A.... Takata M.	2003	PRNP
20	Disease-associated F198S mutation increases the prope nsity of the recombinant prion protein for conformational conversion to scrapie -like form. (12372829)	Vanik D.L.... Surewicz W.K.	2002	PRNP
21	Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain. (11967328)	Mabbott N.A.... Bruce M.E.	2002	PRNP
22	Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein. (11259656)	Vilette D.... Laude H.	2001	PRNP
23	Ovine scrapie: priorities and importance. (11501410)	NovA!k M.... TkA!cikovA! L.	2000	PRNP
24	Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie. (10653023)	Beekes M.... McBride P.A.	2000	PRNP
25	Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. (10545999)	Brown K.L.... Bruce M.E.	1999	PRNP
26	Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie. (10327187)	McBride P.A.... Beekes M.	1999	PRNP
27	Scrapie-free Merino and Poll Dorset sheep from Australia and New Zealand have normal frequencies of scrapie-susceptible PrP genotypes. (9714260)	Hunter N.... Cairns D.	1998	PRNP
28	Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. (9516475)	Dandoy-Dron F.... Dron M.	1998	SCRG1
29	Melatonin and prolactin secretion profile in naturall y occurring scrapie in ewe. (9510437)	Picard-Hagen N.... Toutain P.L.	1998	PRL
30	Guidance on the use of PrP genotyping as an aid to th e control of clinical scrapie. Scrapie Information Group. (9650232)	Dawson M.... Hunter N.	1998	PRNP
31	Characterization of the sheep apolipoprotein E (ApoE) gene and allelic variations of the ApoE gene in scrapie Suffolk sheep. (9524247)	Komatsu Y.... Shinagawa M.	1998	APOE, PRNP
32	A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells. (9450686)	Lehmann S.... Harris D.A.	1997	PRNP
33	Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie. (7636494)	Clouscard C.... Laplanche J.L.	1995	PRNP
34	Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues. (7913757)	Caughey B.	1994	PRNP
35	PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host o f scrapie. (7909834)	Goldmann W.... Hope J.	1994	PRNP
36	PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. (8094373)	Laplanche J.L.... Launay J.M.	1993	PRNP
37	Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. (7678300)	Caughey B.... Raymond G.J.	1993	PRNP
38	The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)	Wisniewski H.M.... Wegiel J.	1992	PRNP
39	Relationship of protease-resistant protein, scrapie-associated fibrils and tubulofilamentous particles to the agent of spongiform encephalopathies. (1363618)	Narang H.K.	1992	PRNP
40	Molecular biology of prions causing infectious and genetic encephalopathies of humans as well as scrapie of sheep and BSE of cattle. (1686599)	Prusiner S.B.	1991	PRNP
41	New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred. (1671440)	Goldfarb L.G.... Gajdusek D.C.	1991	PRNP
42	Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia. (1975028)	Goldfarb L.... Gajdusek D.C.	1990	PRNP
43	The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. (1972856)	Brown H.R.... Robakis N.K.	1990	PRNP
44	Subcellular distribution and physicochemical properti es of scrapie-associated precursor protein and relationship with scrapie agent. (1969124)	Safar J.... Gibbs C.J.	1990	PRNP
45	Cellular isoform of the scrapie agent protein partici pates in lymphocyte activation. (1969332)	Cashman N.R.... Bendheim P.E.	1990	PRNP
46	Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis. (2119503)	Brown P.... Gajdusek D.C.	1990	PRNP
47	Differential glycosylation of the protein (PrP) forming scrapie-associated fibrils. (1969925)	Somerville R.A.... Ritchie L.A.	1990	PRNP
48	Ultrastructure of the cells forming amyloid fibers in Alzheimer disease and scrapie. (1963537)	Wisniewski H.M.... Lossinsky A.S.	1990	ENTPD5
49	Scrapie-associated precursor proteins: antigenic relationship between species and immunocytochemical localization in normal, scrapie, and Creutzfeldt-Jakob disease brains. (1969126)	Safar J.... Gibbs C.J.	1990	PRNP
50	Changes in brain gene expression shared by scrapie and Alzheimer disease. (2780570)	Duguid J.R.... Tourtellotte W.W.	1989	TF, CLU, GFAP

Genes related to scrapie according to GeneCards:

(show all 38)

id	Symbol	Description	Score	GeneCards Section Context
1	SCRG1	stimulator of chondrogenesis 1	11.1	Publications, Summaries, Proteins, Orthologs (show all 5 sections) Aliases & Descriptions
2	PRNP	prion protein	11.0	Publications
3	PRND	prion protein 2 (dublet)	11.0	Publications
4	PVALB	parvalbumin	11.0	Publications
5	CLU	clusterin	11.0	Publications
6	CST3	cystatin C	11.0
7	MAPT	microtubule-associated protein tau	11.0	Publications
8	MORF4	mortality factor 4	11.0
9	SERF1B	small EDRK-rich factor 1B (centromeric)	11.0	Disorders
10	SERF1A	small EDRK-rich factor 1A (telomeric)	11.0
11	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	11.0
12	MT2A	metallothionein 2A	11.0	Publications
13	FLOT1	flotillin 1	11.0	Publications
14	NARFL	nuclear prelamin A recognition factor-like	11.0
15	PIGQ	phosphatidylinositol glycan anchor biosynthesis, class Q	11.0	Disorders
16	MYL4	myosin, light chain 4, alkali; atrial, embryonic	11.0
17	MSMB	microseminoprotein, beta-	11.0	Publications
18	RPSA	ribosomal protein SA	11.0	Publications
19	ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	11.0	Publications
20	RABEPK	Rab9 effector protein with kelch motifs	11.0
21	SSBP1	single-stranded DNA binding protein 1, mitochondrial	11.0
22	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
23	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	11.0	Publications
24	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
25	RNF111	ring finger protein 111	11.0
26	CAST	calpastatin	11.0	Publications
27	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
28	LARS	leucyl-tRNA synthetase	11.0
29	LDLRAP1	low density lipoprotein receptor adaptor protein 1	11.0
30	GFAP	glial fibrillary acidic protein	11.0	Publications
31	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0
32	TF	transferrin	11.0	Publications
33	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
34	PLCB4	phospholipase C, beta 4	11.0	Publications
35	PRL	prolactin	11.0	Publications
36	APP	amyloid beta (A4) precursor protein	11.0	Publications
37	APOE	apolipoprotein E	11.0	Publications
38	ERC1	ELKS/RAB6-interacting/CAST family member 1	11.0

Pathways related to scrapie according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Alzheimers Disease Pathway36	8.9	APOE, APP, MAPT
2	Neuroscience3	8.4	APP, ENO2, MAPT, CAST, NOS1, GFAP
3	Alzheimers disease20	7.7	NOS1, PLCB4, MAPT, APP, APOE

Compounds related to scrapie according to GeneDecks:

(show top 50)    (show all 76)

id	Compound	Score	Top Affiliating Genes
1	gelfoam32	10.0	GFAP, MAPT, TF
2	quinolinic acid32 18	10.9	PVALB, ITIH4, BLVRB, GFAP
3	silver32	9.9	CST3, ENO2, PVALB, GFAP, MAPT
4	alanine32	9.7	CST3, ITIH4, GFAP, TF
5	memantine32 9 9	11.6	ITIH4, APP, MAPT
6	thioflavine s32	9.3	APOE, MAPT, APP
7	spec-t32	9.3	APOE, GFAP, ENO2, MAPT
8	leupeptin32	9.2	CST3, APP, CAST, ITIH4, TF
9	ganglioside32	9.2	ENO2, ITIH4, FLOT1, PRNP, GFAP, APP
10	kainate32	9.2	BLVRB, PVALB, GFAP, MAPT, APOE, CLU
11	superoxide32 18	10.2	MT2A, BLVRB, CLU, ENO2, NOS1, GFAP
12	tacrine32 9 9	11.1	MAPT, APP, APOE
13	lactate32	9.1	MAPT, TF, CST3, GFAP, ENO2, ITIH4
14	sialic acid32	9.1	ENO2, PLCB4, TF, CLU, CST3
15	donepezil32 9 18 9	12.0	MAPT, APP, APOE
16	tetrodotoxin32	9.0	APOE, PVALB, GFAP, NOS1, ENO2
17	formate32	8.9	GFAP, MAPT, APP, APOE, PRNP
18	fluorescein32 9 9	10.9	PLCB4, ITIH4, APOE, TF
19	methotrexate32 34 42 9 9	12.8	CST3, TF, NOS1, ENO2, MT2A, APP
20	formaldehyde32 18	9.8	PRNP, PVALB, GFAP, NOS1, ENO2, BLVRB
21	sodium dodecylsulfate32	8.8	APOE, ITIH4, APP, MAPT, PRNP
22	iron32 18	9.7	APP, GFAP, PVALB, TF, BLVRB, PRNP
23	corticosterone32 18	9.7	NOS1, APP, ITIH4, GFAP, PRL
24	polyethylene glycol32	8.6	CST3, APOE, PRL, TF, GFAP
25	chloroquine32 34 9 9	11.6	ITIH4, APOE, APP, TF, MAPT
26	gaba32 42	9.6	PVALB, GFAP, NOS1, ENO2, TF, APP
27	choline32 9 18 9	11.5	APP, ENO2, MAPT, NOS1, GFAP, PVALB
28	lactacystin32	8.5	NOS1, APOE, MAPT, CAST, APP
29	valine32	8.4	NOS1, PRNP, PRND, ITIH4, APP, APOE
30	cocaine32 9 9	10.3	PRL, ITIH4, NOS1, GFAP, TF
31	paraffin32	8.2	BLVRB, CLU, ITIH4, APOE, TF, ENO2
32	acetylcholine32 9 18 9	11.0	BLVRB, APOE, APP, ENO2, MAPT, NOS1
33	heparin32 9 18 9	11.0	ENO2, ITIH4, PRNP, PLCB4, CLU, APOE
34	h2o232	7.9	MAPT, NOS1, APP, APOE, ITIH4, MT2A
35	nmda32 42	8.8	ITIH4, GFAP, BLVRB, PVALB, APOE, APP
36	dexamethasone32 42 34 9 9	11.8	NOS1, PRL, GFAP, PLCB4, ENO2, APP
37	cyclosporin a32 42	8.7	CST3, ITIH4, APOE, MAPT, NOS1, TF
38	folate32	7.7	TF, CLU, MT2A, APOE, MAPT, PLCB4
39	glutamine32	7.6	TF, ITIH4, APOE, APP, MAPT, ENO2
40	estrogen32	7.5	PRL, TF, PVALB, GFAP, MT2A, APOE
41	creatinine32	7.5	NOS1, GFAP, CST3, TF, CAST, MAPT
42	aspartate32	7.4	MAPT, NOS1, GFAP, PVALB, PRNP, CST3
43	vegf32	7.4	NOS1, CLU, CST3, TF, GFAP, APOE
44	testosterone32 9 18 9	10.3	BLVRB, CLU, MSMB, APOE, APP, GFAP
45	cholesterol32 9 18 9	10.3	APP, CST3, PRNP, ENO2, TF, GFAP
46	lipid32	7.3	MT2A, FLOT1, APOE, CLU, APP, ENO2
47	glutamate32	6.9	PRNP, TF, NOS1, CAST, ENO2, PVALB
48	arginine32	6.9	MAPT, APP, PLCB4, NOS1, GFAP, PRL
49	cysteine32	6.9	CST3, GFAP, APP, ITIH4, APOE, MAPT
50	dopamine32 9 18 9	9.8	APP, PVALB, CLU, ITIH4, APOE, MAPT

Cellular components related to scrapie according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	8.7	SCN2A, LDLRAP1, APP, MAPT, PVALB
2	cytosol	GO:005829	6.9	MAPT, PLCB4, NOS1, RPSA, GFAP, ENO2

Biological processes related to scrapie according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of endopeptidase activity	GO:010951	9.8	ITIH4, CAST, CST3
2	cellular copper ion homeostasis	GO:006878	9.2	MT2A, APP, PRND, PRNP

Molecular functions related to scrapie according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endopeptidase inhibitor activity	GO:004866	9.8	ITIH4, CAST, CST3
2	beta-amyloid binding	GO:001540	8.9	LDLRAP1, APOE, CST3