MCID: SCR016
MIFTS: 35

Scrotal Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Scrotal Carcinoma

MalaCards integrated aliases for Scrotal Carcinoma:

Name: Scrotal Carcinoma 12 14 69
Neoplasm of Scrotum 12 69
Scrotum Neoplasm 12 14
Malignant Neoplasm of Scrotum 69
Malignant Tumour of Scrotum 12
Malignant Scrotal Neoplasm 12
Malignant Tumor of Scrotum 12
Carcinoma of Scrotum 12
Scrotum Cancer 12
Scrotal Tumor 12
Scrotal Ca 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3445 DOID:518
ICD10 33 C63.2
ICD9CM 35 187.7

Summaries for Scrotal Carcinoma

MalaCards based summary : Scrotal Carcinoma, also known as neoplasm of scrotum, is related to scrotum squamous cell carcinoma and scrotum basal cell carcinoma, and has symptoms including pain in scrotum An important gene associated with Scrotal Carcinoma is CDKN2B (Cyclin Dependent Kinase Inhibitor 2B), and among its related pathways/superpathways are HTLV-I infection and Cell cycle. The drugs Paclitaxel and Cisplatin have been mentioned in the context of this disorder. Related phenotype is neoplasm.

Related Diseases for Scrotal Carcinoma

Diseases related to Scrotal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
id Related Disease Score Top Affiliating Genes
1 scrotum squamous cell carcinoma 10.9
2 scrotum basal cell carcinoma 10.9
3 cervical adenoid cystic carcinoma 10.7 CDKN2A TP53
4 split hand split foot nystagmus 10.7 CDKN2A TP53
5 benign pleural mesothelioma 10.7 CDKN2A CDKN2B
6 leiomyoma cutis 10.7 CDKN2A TP53
7 anal squamous cell carcinoma 10.7 CDKN2A TP53
8 rectum squamous cell carcinoma 10.7 CDKN2A TP53
9 breast myoepitheliosis 10.7 CDKN2A TP53
10 coccidiosis 10.6 CDKN2A TP53
11 adenocarcinoma in situ 10.6 CDKN2A TP53
12 duodenum cancer 10.6 CDKN2A TP53
13 retinal detachment 10.6 CDKN2A TP53
14 larynx carcinoma in situ 10.6 CDKN2A TP53
15 exertional headache 10.6 CDKN2A CDKN2B
16 phalanx chondroma 10.6 CDKN2A TP53
17 olfactory neural tumor 10.6 CDKN2A TP53
18 orbital lymphoma 10.6 CDKN2A TP53
19 non-suppurative otitis media 10.6 CDKN2A TP53
20 pancreatic agenesis 10.6 CDKN2A TP53
21 villous adenocarcinoma 10.6 CDKN2A TP53
22 spastic ataxia 3 10.6 CDKN2A TP53
23 esophagus squamous cell carcinoma 10.6 CDKN2A TP53
24 pediatric osteosarcoma 10.6 CDKN2A TP53
25 bladder squamous cell carcinoma 10.6 CDKN2A TP53
26 advanced sleep phase syndrome 10.6 CDKN2A TP53
27 plasmodium ovale malaria 10.6 CDKN2A TP53
28 internal auditory canal lipoma 10.6 CDKN2A TP53
29 middle ear squamous cell carcinoma 10.6 CDKN2A TP53
30 childhood oligodendroglioma 10.6 CDKN2A TP53
31 c-p angle neurinoma 10.6 CDKN2A TP53
32 vestibular disease 10.5 CDKN2A TP53
33 secondary hyperparathyroidism of renal origin 10.5 CDKN2A TP53
34 molluscum contagiosum 10.5 CDKN2A TP53
35 fallopian tube squamous cell carcinoma 10.5 CD68 TP53
36 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 10.5 CDKN2A TP53
37 ductal carcinoma in situ 10.5 CDKN2A TP53
38 cecum adenocarcinoma 10.5 CDKN2A TP53
39 enamel hypoplasia cataract hydrocephaly 10.5 SERPINA3 TP53
40 fibrous meningioma 10.5 CD68 CDKN2A
41 adult liposarcoma 10.5 CDKN2A HMGA2
42 pancreatoblastoma 10.5 CDKN2A TP53
43 asthenopia 10.5 CD68 TP53
44 vaginal adenoma 10.5 HMGA2 SERPINA3
45 louse-borne relapsing fever 10.5 AFP CDKN2A
46 choriocarcinoma 10.5 CDKN2A TP53
47 hypersensitivity reaction type iii disease 10.5 AFP TP53
48 neurofibroma of the esophagus 10.4 CD68 CDKN2A
49 spindle epithelial tumor with thymus-like differentiation tumor 10.4 CD68 CDKN2A
50 biliary dyskinesia 10.4 CD68 TP53

Graphical network of the top 20 diseases related to Scrotal Carcinoma:



Diseases related to Scrotal Carcinoma

Symptoms & Phenotypes for Scrotal Carcinoma

UMLS symptoms related to Scrotal Carcinoma:


pain in scrotum

MGI Mouse Phenotypes related to Scrotal Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 AFP CDKN2A CDKN2B SMUG1 TP53

Drugs & Therapeutics for Scrotal Carcinoma

Drugs for Scrotal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
3
Ifosfamide Approved Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 3 51-75-2 4033
5 Isophosphamide mustard Phase 3
6 Alkylating Agents Phase 3
7 Albumin-Bound Paclitaxel Phase 3
8 Antimitotic Agents Phase 3
9 Antineoplastic Agents, Phytogenic Phase 3
10
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Not yet recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer Completed NCT01526486

Search NIH Clinical Center for Scrotal Carcinoma

Genetic Tests for Scrotal Carcinoma

Anatomical Context for Scrotal Carcinoma

Publications for Scrotal Carcinoma

Articles related to Scrotal Carcinoma:

id Title Authors Year
1
Emergency endovascular management of the common femoral artery rupture due to radiotherapy for scrotal carcinoma. ( 25610613 )
2015
2
A case report of scrotal carcinoma and review of the literature. ( 22949906 )
2012
3
Scrotal carcinoma. ( 21791720 )
2011
4
Scrotal carcinoma: a reminder of a disappearing occupational disease. ( 21686921 )
2009
5
Verrucous scrotal carcinoma in a patient with hypospadias: is there a possible association? ( 12559309 )
2003
6
Dynamic lymphoscintigraphy for staging scrotal carcinoma. ( 11176424 )
2001
7
Verrucous scrotal carcinoma: a radioresponsive tumor. ( 10524907 )
1999
8
Scrotal carcinoma following prolonged use of crude coal tar ointment. ( 2702411 )
1989
9
A population-based study of survival after scrotal carcinoma. ( 3965115 )
1985
10
Scrotal carcinoma in Connecticut metalworkers: sequel to a study of sinonasal cancer. ( 7102658 )
1982

Variations for Scrotal Carcinoma

Expression for Scrotal Carcinoma

Search GEO for disease gene expression data for Scrotal Carcinoma.

Pathways for Scrotal Carcinoma

GO Terms for Scrotal Carcinoma

Cellular components related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.73 CDKN2A CDKN2B HMGA2 TP53
2 cell cycle arrest GO:0007050 9.5 CDKN2A CDKN2B TP53
3 positive regulation of cell cycle arrest GO:0071158 9.4 HMGA2 TP53
4 negative regulation of phosphorylation GO:0042326 9.37 CDKN2A CDKN2B
5 replicative senescence GO:0090399 9.26 CDKN2A TP53
6 positive regulation of cellular senescence GO:2000774 9.16 CDKN2A HMGA2
7 senescence-associated heterochromatin focus assembly GO:0035986 8.96 CDKN2A HMGA2
8 base-excision repair GO:0006284 8.8 HMGA2 SMUG1 TP53

Molecular functions related to Scrotal Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.65 TP53
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Scrotal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....