MCID: SCR008
MIFTS: 65

Scrub Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

MalaCards integrated aliases for Scrub Typhus:

Name: Scrub Typhus 12 55 51 3 41 14 69
Tsutsugamushi Disease 12 55
Tsutsugamushi Fever 12 55
Typhus Fever Due to Rickettsia Tsutsugamushi 12
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

55
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Scrub Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Scrub Typhus, also known as tsutsugamushi disease, is related to epidemic typhus and acalculous cholecystitis, and has symptoms including fever, headache and muscle pain. An important gene associated with Scrub Typhus is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Akt Signaling and Toll-Like receptor Signaling Pathways. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and skin, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

Wikipedia : 72 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 32.1 CD40LG GPT TCN2
2 acalculous cholecystitis 30.6 CD40LG CRP
3 japanese spotted fever 30.5 CD40LG CRP
4 hepatitis 30.5 GPT SLC17A5 TNF
5 mononeuritis multiplex 30.3 CD40LG CRP
6 vasculitis 30.1 CD40LG CRP TNF
7 hellp syndrome 30.1 F3 GPT SLC17A5
8 hepatitis a 30.0 F3 GPT TNF
9 respiratory failure 30.0 CRP F3 IL10 TNF
10 transverse myelitis 29.9 IL10 TNF
11 aseptic meningitis 29.8 IL10 IL1B TNF
12 stroke, ischemic 29.6 CRP F3 TLR4
13 hemorrhagic fever with renal syndrome 29.5 CD40LG CRP IL10 TNF
14 viral hepatitis 29.3 CD40LG GPT SLC17A5 TLR2 TNF
15 bacterial meningitis 29.2 CRP IL10 IL1B TLR2 TNF
16 peritonitis 29.2 CRP IL10 IL1B TLR2 TNF
17 leptospirosis 29.1 CD40LG CRP IL10 IL1B TLR2 TNF
18 meningitis 29.0 CD40LG CRP IL10 IL1B TLR2 TNF
19 q fever 28.8 CD40LG IL10 IL1B TLR2 TLR4 TNF
20 lyme disease 28.7 CD40LG CRP IL1B TLR2 TNF
21 hemorrhagic fever 28.7 CD40LG F3 GPT IL10 SLC17A5 TNF
22 pneumonia 28.1 CD40LG CRP IL10 IL1B TLR2 TLR4
23 myocardial infarction 27.5 CD40LG CRP F3 IL10 IL1B TLR4
24 malaria 27.0 CD40LG CRP F3 IL10 IL1B TCN2
25 endemic typhus 11.7
26 paraquat poisoning 10.6 GPT SLC17A5
27 pyridoxine deficiency 10.5 GPT SLC17A5
28 pyomyositis 10.5 CRP GPT
29 kwashiorkor 10.5 GPT SLC17A5
30 adult dermatomyositis 10.5 GPT TNF
31 acute respiratory distress syndrome 10.4
32 melancholia 10.4 CRP TNF
33 punctate inner choroidopathy 10.4 IL10 TNF
34 neurosyphilis 10.4 IL10 TLR2
35 tropical endomyocardial fibrosis 10.4 IL10 TNF
36 microscopic polyangiitis 10.4 IL10 TNF
37 multifocal choroiditis 10.4 IL10 TNF
38 tungiasis 10.4 IL10 TNF
39 endomyocardial fibrosis 10.4 IL10 TNF
40 relapsing fever 10.4 CRP TNF
41 spotted fever 10.4
42 transient hypogammaglobulinemia 10.4 IL10 TNF
43 choroiditis 10.4 IL10 TNF
44 dental abscess 10.4 CRP TLR4
45 rocky mountain spotted fever 10.3 CD40LG SLC17A5
46 spondylarthropathy 10.3 TLR4 TNF
47 mucocutaneous leishmaniasis 10.3 IL10 TNF
48 idiopathic achalasia 10.3 IL10 TNF
49 acute cervicitis 10.3 TLR2 TLR4
50 trichuriasis 10.3 IL10 TNF

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Symptoms:

12
  • fever
  • headache
  • muscle pain
  • cough
  • maculopapular rash
  • eschar
  • splenomegaly
  • lymphadenopathy

Human phenotypes related to Scrub Typhus:

55 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
2 photophobia 55 31 frequent (33%) Frequent (79-30%) HP:0000613
3 hyperhidrosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000975
4 skin rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0000988
5 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
6 lethargy 55 31 hallmark (90%) Very frequent (99-80%) HP:0001254
7 meningitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001287
8 tremor 55 31 occasional (7.5%) Occasional (29-5%) HP:0001337
9 splenomegaly 55 31 occasional (7.5%) Occasional (29-5%) HP:0001744
10 abnormal bleeding 55 31 occasional (7.5%) Occasional (29-5%) HP:0001892
11 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
12 nausea and vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002017
13 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
14 dyspnea 55 31 occasional (7.5%) Occasional (29-5%) HP:0002094
15 headache 55 31 frequent (33%) Frequent (79-30%) HP:0002315
16 encephalitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002383
17 hypotension 55 31 frequent (33%) Frequent (79-30%) HP:0002615
18 lymphadenopathy 55 31 frequent (33%) Frequent (79-30%) HP:0002716
19 myalgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0003326
20 anterior uveitis 55 31 frequent (33%) Frequent (79-30%) HP:0012122
21 macule 55 31 frequent (33%) Frequent (79-30%) HP:0012733
22 cough 55 31 hallmark (90%) Very frequent (99-80%) HP:0012735
23 myocarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012819
24 gangrene 55 31 frequent (33%) Frequent (79-30%) HP:0100758
25 behavioral abnormality 55 Occasional (29-5%)
26 restrictive lung disease 55 Occasional (29-5%)
27 reduced consciousness/confusion 55 Very frequent (99-80%)
28 restrictive ventilatory defect 31 occasional (7.5%) HP:0002091

MGI Mouse Phenotypes related to Scrub Typhus:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 CD40LG CRP TLR2 F3 TLR4 IL10
2 cardiovascular system MP:0005385 10.01 TLR2 CRP F3 TLR4 IL10 TNF
3 immune system MP:0005387 9.92 CD40LG CRP TLR2 F3 TLR4 IL10
4 integument MP:0010771 9.8 TLR2 F3 TLR4 IL10 TNF IL1B
5 neoplasm MP:0002006 9.63 TLR2 F3 TLR4 IL10 TNF IL1B
6 nervous system MP:0003631 9.56 SLC17A5 CD40LG TLR2 F3 TLR4 IL10
7 skeleton MP:0005390 9.17 CD40LG TLR2 TLR4 GPT IL10 TNF

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4,Phase 3
6 Antimalarials Phase 4,Phase 3
7 Antiparasitic Agents Phase 4,Phase 3
8 Antiprotozoal Agents Phase 4,Phase 3
9 Antitubercular Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 0 5462516
11
Rifampin Approved 13292-46-1 5381226 5458213
12
Ethanol Approved 64-17-5 702
13 Cytochrome P-450 CYP3A Inducers
14 Nucleic Acid Synthesis Inhibitors
15 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 doxycycline;rifampin
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus RDT Study Recruiting NCT03269266
6 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
7 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
8 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
9 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367
10 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

38
Testes, Lung, Skin, Kidney, Liver, T Cells, Monocytes

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 688)
# Title Authors Year
1
Dysregulated Th1 Immune and Vascular Responses in Scrub Typhus Pathogenesis. ( 29431689 )
2018
2
Clinical proteomic analysis of scrub typhus infection. ( 29449793 )
2018
3
Predictors of Severity in Pediatric Scrub Typhus. ( 29368107 )
2018
4
Scrub typhus reinfection. ( 29137528 )
2018
5
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
6
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
7
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
8
Scrub Typhus Outbreak in Chonburi Province, Central Thailand, 2013. ( 29350148 )
2018
9
Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection. ( 29430404 )
2018
10
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
11
Clinical manifestations of scrub typhus. ( 28449088 )
2017
12
Lateral Flow Rapid Test for Accurate and Early Diagnosis of Scrub Typhus: A Febrile Illness of Historically Military Importance in the Pacific Rim. ( 28291501 )
2017
13
Serologic Evidence of Scrub Typhus in the Peruvian Amazon. ( 28726619 )
2017
14
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
15
Typhoid and Scrub Typhus Coinfection in a Returned Traveler. ( 28890912 )
2017
16
Scrub typhus meningitis in a renal transplant recipient. ( 28356672 )
2017
17
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
18
The genotypes of Orientia tsutsugamushi, identified in scrub typhus patients in northern Vietnam. ( 28531311 )
2017
19
Drug treatment of scrub typhus: a systematic review and meta-analysis of controlled clinical trials. ( 29253266 )
2017
20
Epidemiological characteristics of scrub typhus on the Jeju Island. ( 29370684 )
2017
21
Increased level and interferon-I^ production of circulating natural killer cells in patients with scrub typhus. ( 28750012 )
2017
22
Acute-phase diagnosis of murine and scrub typhus in Belgian travelers by polymerase chain reaction: a case report. ( 28407761 )
2017
23
Climate variability, animal reservoir and transmission of scrub typhus in Southern China. ( 28273079 )
2017
24
Scrub Typhus Outbreak in a Remote Primary School, Bhutan, 2014. ( 28726604 )
2017
25
Epidemiological, clinical and laboratory profile of scrub typhus cases detected by serology and RT-PCR in Kumaon, Uttarakhand: a hospital-based study. ( 29173047 )
2017
26
A review of the global epidemiology of scrub typhus. ( 29099844 )
2017
27
Guillain-Barre Syndrome with Falciparum Malaria and Scrub Typhus Mixed Infection-An Unusual Combination. ( 29207762 )
2017
28
Differences in agricultural activities related to incidence of scrub typhus between Korea and Japan. ( 29121711 )
2017
29
Validation of Geno-Sen's Scrub Typhus Real Time Polymerase Chain Reaction Kit by its Comparison with a Serological ELISA Test. ( 28878522 )
2017
30
Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients. ( 29259327 )
2017
31
Scrub typhus: A prospective, observational study during an outbreak in Rajasthan, India. ( 28816212 )
2017
32
Renal Manifestation in Scrub Typhus during a Major Outbreak in Central Nepal. ( 29217880 )
2017
33
Rapid increase of scrub typhus incidence in Guangzhou, southern China, 2006-2014. ( 28056840 )
2017
34
Use of eschar swabbing for the molecular diagnosis and genotyping of Orientia tsutsugamushi causing scrub typhus in Quang Nam province, Vietnam. ( 28241043 )
2017
35
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
36
Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans. ( 28892515 )
2017
37
Dengue and Scrub Typhus Coinfection in a Patient Presenting with Febrile Illness. ( 28386493 )
2017
38
Differentiation of severe fever with thrombocytopenia syndrome from scrub typhus. ( 29293899 )
2017
39
Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. ( 28709838 )
2017
40
Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin. ( 28461826 )
2017
41
Clinical Profile of Scrub Typhus Meningoencephalitis among South Indian Children. ( 29272545 )
2017
42
Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001-2013). ( 28298367 )
2017
43
Clinical Score to Differentiate Scrub Typhus and Dengue: A Tool to Differentiate Scrub Typhus and Dengue. ( 28250620 )
2017
44
Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus. ( 28419138 )
2017
45
Epidemiologic characteristics of scrub typhus in Jeju Island, Korea. ( 28823118 )
2017
46
Meteorological factors affecting scrub typhus occurrence: a retrospective study of Yamagata Prefecture, Japan, 1984-2014. ( 27788693 )
2017
47
Scrub typhus: radiological and clinical findings in abdominopelvic involvement. ( 28044222 )
2017
48
Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis. ( 28885357 )
2017
49
Scrub Typhus as a Cause of Acute Encephalitis Syndrome, Gorakhpur, Uttar Pradesh, India. ( 28726617 )
2017
50
Rickettsial Infections in Goa-Not Just Scrub Typhus! ( 28799301 )
2017

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

Pathways related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CD40LG IL10 IL1B TLR2 TLR4 TNF
2
Show member pathways
12.86 F3 IL1B TLR2 TLR4 TNF
3
Show member pathways
12.73 CD40LG IL10 IL1B TNF
4
Show member pathways
12.68 IL1B TLR2 TLR4 TNF
5
Show member pathways
12.59 CD40LG IL1B TLR2 TLR4 TNF
6
Show member pathways
12.52 CD40LG IL1B TLR2 TLR4 TNF
7
Show member pathways
12.48 IL10 IL1B TLR2 TLR4 TNF
8 12.45 CD40LG IL10 IL1B TLR2 TNF
9
Show member pathways
12.41 IL10 IL1B TLR2 TLR4 TNF
10
Show member pathways
12.34 CD40LG IL10 IL1B TNF
11
Show member pathways
12.25 CRP IL1B TCN2 TNF
12
Show member pathways
12.16 IL1B TLR4 TNF
13
Show member pathways
12.11 IL1B TLR4 TNF
14 12.11 IL10 IL1B TLR2 TLR4 TNF
15
Show member pathways
12.1 IL1B TLR2 TLR4 TNF
16 12.08 TLR2 TLR4 TNF
17 12.07 IL10 IL1B TNF
18
Show member pathways
12.05 IL10 IL1B TNF
19
Show member pathways
11.93 IL1B TLR2 TLR4
20 11.91 IL1B TLR4 TNF
21
Show member pathways
11.9 CD40LG IL10 IL1B TLR2 TLR4 TNF
22 11.89 IL10 IL1B TNF
23 11.82 F3 IL1B TNF
24 11.79 CD40LG IL1B TLR4 TNF
25
Show member pathways
11.78 IL1B TLR2 TLR4
26 11.75 IL1B TLR2 TLR4 TNF
27
Show member pathways
11.74 IL10 IL1B TLR2 TLR4 TNF
28 11.71 IL10 IL1B TNF
29 11.67 IL10 IL1B TNF
30 11.66 IL10 IL1B TLR4 TNF
31 11.64 IL10 IL1B TLR2 TLR4 TNF
32
Show member pathways
11.59 CD40LG IL1B TNF
33 11.47 IL10 IL1B TNF
34 11.47 IL1B TLR2 TLR4 TNF
35 11.39 IL1B TLR2 TLR4 TNF
36 11.29 IL10 IL1B TNF
37 11.21 IL10 IL1B TNF
38 11.21 IL10 IL1B TLR4 TNF
39 11.17 CD40LG IL10 TLR2 TLR4 TNF
40 11.13 CD40LG IL10 IL1B TNF
41 11.09 IL1B TLR2
42 11.02 IL1B TNF
43 10.95 CRP TNF
44 10.87 IL1B TNF
45 10.79 CD40LG IL10 IL1B TLR2 TLR4 TNF

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CD40LG CRP F3 IL10 IL1B TCN2
2 cell surface GO:0009986 9.35 CD40LG F3 TLR2 TLR4 TNF
3 extracellular space GO:0005615 9.23 CD40LG CRP F3 GPT IL10 IL1B

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.99 CD40LG IL10 IL1B TNF
2 positive regulation of gene expression GO:0010628 9.92 CRP IL1B TLR2 TLR4 TNF
3 immune response GO:0006955 9.91 CD40LG IL10 IL1B TLR2 TLR4 TNF
4 response to lipopolysaccharide GO:0032496 9.88 IL10 IL1B TLR2 TLR4
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 IL1B TLR4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.86 IL10 TLR4 TNF
7 activation of MAPK activity GO:0000187 9.85 IL1B TLR4 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL10 IL1B TNF
9 defense response to Gram-positive bacterium GO:0050830 9.82 CRP TLR2 TNF
10 positive regulation of JNK cascade GO:0046330 9.79 IL1B TLR4 TNF
11 positive regulation of interferon-gamma production GO:0032729 9.74 IL1B TLR4 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IL1B TLR4 TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 CD40LG IL1B TLR2 TLR4 TNF
14 negative regulation of interferon-gamma production GO:0032689 9.71 IL10 TLR4
15 positive regulation of interferon-beta production GO:0032728 9.7 TLR2 TLR4
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.7 IL10 TNF
17 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
19 negative regulation of interleukin-6 production GO:0032715 9.69 IL10 TLR4 TNF
20 positive regulation of macrophage activation GO:0043032 9.68 IL10 TLR4
21 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR2 TLR4
24 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2
25 positive regulation of interleukin-12 production GO:0032735 9.67 CD40LG TLR2 TLR4
26 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TLR2 TLR4 TNF
27 I-kappaB phosphorylation GO:0007252 9.66 TLR2 TLR4
28 regulation of cytokine secretion GO:0050707 9.65 TLR2 TLR4
29 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
30 positive regulation of interleukin-10 production GO:0032733 9.65 CD40LG TLR2 TLR4
31 negative regulation of lipid storage GO:0010888 9.64 CRP TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 TLR4 TNF
34 endothelial cell apoptotic process GO:0072577 9.63 IL10 TNF
35 positive regulation of chemokine production GO:0032722 9.63 TLR2 TLR4 TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 TLR4
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
39 positive regulation of fever generation GO:0031622 9.6 IL1B TNF
40 regulation of immunoglobulin secretion GO:0051023 9.59 CD40LG TNF
41 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
43 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 IL1B TLR2 TLR4 TNF
44 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
46 positive regulation of interleukin-8 production GO:0032757 9.46 IL1B TLR2 TLR4 TNF
47 positive regulation of NF-kappaB import into nucleus GO:0042346 9.26 IL1B TLR2 TLR4 TNF
48 inflammatory response GO:0006954 9.17 CD40LG CRP IL10 IL1B TLR2 TLR4
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 IL10 IL1B TLR2 TLR4 TNF

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
2 cytokine activity GO:0005125 8.92 CD40LG IL10 IL1B TNF

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....