MCID: SCR008
MIFTS: 55

Scrub Typhus malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Scrub Typhus

Aliases & Descriptions for Scrub Typhus:

Name: Scrub Typhus 12 56 52 42 14 69
Tsutsugamushi Disease 12 56
Tsutsugamushi Fever 12 56
Typhus Fever Due to Rickettsia Tsutsugamushi 12
Chigger-Borne Rickettsiosis 12
Mite-Borne Rickettsiosis 12
Scrub Mite-Borne Typhus 12
Chigger-Borne Typhus 12
Japanese River Fever 12
Mite-Borne Typhus 12
Tropical Typhus 12
Scrub Typhus 12
Tsutsugamushi 12
Kedani Fever 12

Characteristics:

Orphanet epidemiological data:

56
scrub typhus
Prevalence: 1-9/100000 (Korea, Republic of),1-9/1000000 (Japan); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13371
ICD10 33 A75.3 A75.2
ICD9CM 35 081.2
MeSH 42 D012612
Orphanet 56 ORPHA83317
MESH via Orphanet 43 D012612
ICD10 via Orphanet 34 A75.3
UMLS via Orphanet 70 C0036472
UMLS 69 C0036472

Summaries for Scrub Typhus

Disease Ontology : 12 A typhus that has material basis in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Scrub Typhus, also known as tsutsugamushi disease, is related to spotted fever and bacterial meningitis, and has symptoms including fever, headache and muscle pain. An important gene associated with Scrub Typhus is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are NF-kappaB Signaling and Folate Metabolism. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia... more...

Related Diseases for Scrub Typhus

Diseases related to Scrub Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
id Related Disease Score Top Affiliating Genes
1 spotted fever 30.4 CD40LG TLR4
2 bacterial meningitis 29.8 CD40LG CRP GPT
3 granulomatous hepatitis 29.8 CRP F3 IL1B
4 neuropathy 29.5 CRP IL1B TLR4
5 myocardial infarction 29.2 CRP F3 IL10 IL1B
6 leptospirosis 10.3
7 acute respiratory distress syndrome 10.3
8 gastric neuroendocrine tumor type 1 10.3 GPT SLC17A5
9 radiation induced cancer 10.3 GPT SLC17A5
10 heterophyiasis 10.3 CRP GPT
11 female infertility of uterine origin 10.3 GPT SLC17A5
12 q fever 10.2
13 meningitis 10.2
14 pestis minor 10.2 CD40LG SLC17A5
15 maturity-onset diabetes of the young 10.2 CD40LG IL10
16 polycythemia due to hypoxia 10.2 CD40LG CRP
17 midline cystocele 10.2 CRP F3
18 cannabis dependence 10.2 CD40LG CRP
19 retinal cancer 10.2 CRP IL1B
20 leiomyosarcoma 10.2 CD40LG CRP
21 diabetic angiopathy 10.2 CD40LG IL10
22 muscular dystrophy-dystroglycanopathy , type a, 12 10.2 F3 IL1B
23 cataract 10.2 CRP IL1B
24 freiberg's disease 10.2 CD40LG F3
25 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.2 CD40LG F3
26 childhood electroclinical syndrome 10.2 IL10 IL1B
27 hepatitis 10.2
28 meningoencephalitis 10.2
29 chronic mucocutaneous candidiasis 10.2 CD40LG CRP
30 ovarian serous cystadenocarcinoma 10.2 CD40LG CRP
31 dermatophytosis 10.2 CD40LG TCN2
32 chronic fungal otitis externa 10.2 CD40LG CRP
33 facial paralysis 10.2 CD40LG IL10
34 chancroid 10.2 GPT IL1B
35 vogt-koyanagi-harada disease 10.2 F3 GPT
36 secretory diarrhea myopathy and deafness 10.1 CRP F3
37 central gyrate choroidal dystrophy 10.1 CD40LG TCN2
38 oropharyngeal anthrax 10.1 CD40LG CRP
39 acute proliferative glomerulonephritis 10.1 F3 GPT SLC17A5
40 sporotrichosis 10.1 CD40LG F3
41 hemophagocytic lymphohistiocytosis 10.1
42 encephalitis 10.1
43 multiple mitochondrial dysfunctions syndrome 10.1 CRP F3 IL10
44 tarsal tunnel syndrome 10.1 IDO1 IL10
45 cervical adenoid basal carcinoma 10.1 IL10 IL1B
46 egg allergy 10.1 CD40LG IL1B
47 chronic inflammatory demyelinating polyneuritis 10.1 CD40LG F3
48 centronuclear myopathy 5 10.1 CD40LG IL10
49 laryngotracheoesophageal cleft type 2 10.1 CRP IL1B SLC17A5
50 noninfectious dermatoses of eyelid 10.1 CD40LG GPT SLC17A5

Graphical network of the top 20 diseases related to Scrub Typhus:



Diseases related to Scrub Typhus

Symptoms & Phenotypes for Scrub Typhus

Symptoms:

12
  • fever
  • headache
  • muscle pain
  • cough
  • maculopapular rash
  • eschar
  • splenomegaly
  • lymphadenopathy

Human phenotypes related to Scrub Typhus:

56 32 (show all 28)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 myalgia 56 32 Very frequent (99-80%) HP:0003326
2 dyspnea 56 32 Occasional (29-5%) HP:0002094
3 fever 56 32 Very frequent (99-80%) HP:0001945
4 headache 56 32 Frequent (79-30%) HP:0002315
5 seizures 56 32 Occasional (29-5%) HP:0001250
6 tremor 56 32 Occasional (29-5%) HP:0001337
7 photophobia 56 32 Frequent (79-30%) HP:0000613
8 abdominal pain 56 32 Frequent (79-30%) HP:0002027
9 nausea and vomiting 56 32 Frequent (79-30%) HP:0002017
10 lethargy 56 32 Very frequent (99-80%) HP:0001254
11 macule 56 32 Frequent (79-30%) HP:0012733
12 hyperhidrosis 56 32 Very frequent (99-80%) HP:0000975
13 encephalitis 56 32 Occasional (29-5%) HP:0002383
14 hypotension 56 32 Frequent (79-30%) HP:0002615
15 splenomegaly 56 32 Occasional (29-5%) HP:0001744
16 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
17 abnormal bleeding 56 32 Occasional (29-5%) HP:0001892
18 myocarditis 56 32 Occasional (29-5%) HP:0012819
19 skin rash 56 32 Very frequent (99-80%) HP:0000988
20 meningitis 56 32 Occasional (29-5%) HP:0001287
21 cough 56 32 Very frequent (99-80%) HP:0012735
22 lymphadenopathy 56 32 Frequent (79-30%) HP:0002716
23 gangrene 56 32 Frequent (79-30%) HP:0100758
24 anterior uveitis 56 32 Frequent (79-30%) HP:0012122
25 reduced consciousness/confusion 56 Very frequent (99-80%)
26 behavioral abnormality 56 Occasional (29-5%)
27 restrictive lung disease 56 Occasional (29-5%)
28 restrictive ventilatory defect 32 HP:0002091

GenomeRNAi Phenotypes related to Scrub Typhus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.78 IL10 SLC17A5 TLR4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.78 TLR4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.78 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 SLC17A5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.78 TLR4 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.78 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.78 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.78 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 TLR4
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.78 SLC17A5
15 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.78 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.78 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.78 TLR4
19 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IL10 SLC17A5
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.78 SLC17A5
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.78 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.78 IL10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 IL10

MGI Mouse Phenotypes related to Scrub Typhus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 TLR4 CD40LG CRP F3 IDO1 IL10
2 hematopoietic system MP:0005397 9.7 CD40LG F3 GPT IDO1 IL10 IL1B
3 homeostasis/metabolism MP:0005376 9.56 CD40LG CRP F3 IDO1 IL10 IL1B
4 immune system MP:0005387 9.17 CD40LG CRP F3 IDO1 IL10 IL1B

Drugs & Therapeutics for Scrub Typhus

Drugs for Scrub Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4,Phase 3
6 Antimalarials Phase 4,Phase 3
7 Antiparasitic Agents Phase 4,Phase 3
8 Antiprotozoal Agents Phase 4,Phase 3
9 Antitubercular Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 5462516
11
Rifampin Approved 13292-46-1 5458213 5381226
12 Cytochrome P-450 CYP3A Inducers
13 Nucleic Acid Synthesis Inhibitors
14 Vaccines

Interventional clinical trials:


id Name Status NCT ID Phase
1 Scrub Typhus Antibiotic Resistance Trial Not yet recruiting NCT03083197 Phase 4
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
6 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
7 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367
8 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861

Search NIH Clinical Center for Scrub Typhus

Cochrane evidence based reviews: scrub typhus

Genetic Tests for Scrub Typhus

Anatomical Context for Scrub Typhus

MalaCards organs/tissues related to Scrub Typhus:

39
Testes, Lung, Skin, Liver, Kidney, T Cells, Brain

Publications for Scrub Typhus

Articles related to Scrub Typhus:

(show top 50) (show all 648)
id Title Authors Year
1
Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001-2013). ( 28298367 )
2017
2
Use of eschar swabbing for the molecular diagnosis and genotyping of Orientia tsutsugamushi causing scrub typhus in Quang Nam province, Vietnam. ( 28241043 )
2017
3
Scrub typhus meningitis in a renal transplant recipient. ( 28356672 )
2017
4
Evaluation of a broad-ranging and convenient enzyme-linked immunosorbent assay using the lysate of infected cells with five serotypes of Orientia tsutsugamushi, a causative agent of scrub typhus. ( 28056811 )
2017
5
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
6
Scrub typhus: radiological and clinical findings in abdominopelvic involvement. ( 28044222 )
2017
7
Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin. ( 28461826 )
2017
8
Lateral Flow Rapid Test for Accurate and Early Diagnosis of Scrub Typhus: A Febrile Illness of Historically Military Importance in the Pacific Rim. ( 28291501 )
2017
9
Climate variability, animal reservoir and transmission of scrub typhus in Southern China. ( 28273079 )
2017
10
Acute-phase diagnosis of murine and scrub typhus in Belgian travelers by polymerase chain reaction: a case report. ( 28407761 )
2017
11
Rapid increase of scrub typhus incidence in Guangzhou, southern China, 2006-2014. ( 28056840 )
2017
12
Clinical Score to Differentiate Scrub Typhus and Dengue: A Tool to Differentiate Scrub Typhus and Dengue. ( 28250620 )
2017
13
Clinical manifestations of scrub typhus. ( 28449088 )
2017
14
Scrub Typhus Leading to Acute Encephalitis Syndrome, Assam, India. ( 27875108 )
2017
15
Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection. ( 28282373 )
2017
16
Dengue and Scrub Typhus Coinfection in a Patient Presenting with Febrile Illness. ( 28386493 )
2017
17
The genotypes of Orientia tsutsugamushi, identified in scrub typhus patients in northern Vietnam. ( 28531311 )
2017
18
Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus. ( 28419138 )
2017
19
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
20
Meteorological factors affecting scrub typhus occurrence: a retrospective study of Yamagata Prefecture, Japan, 1984-2014. ( 27788693 )
2017
21
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
22
Scrub typhus masquerading as acute pancreatitis. ( 27161204 )
2016
23
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. ( 27966835 )
2016
24
Endemic Scrub Typhus in South America. ( 27602667 )
2016
25
Scrub Typhus in Northeastern Thailand: Eschar Distribution, Abnormal Electrocardiographic Findings, and Predictors of Fatal Outcome. ( 27573633 )
2016
26
Determination of Scrub typhus Suggests a New Epidemic Focus in the Anhui Province of China. ( 26860982 )
2016
27
Scrub typhus infection presenting as acute heart failure: A case report and systematic review of literature of cardiopulmonary involvement in scrub typhus infection. ( 27578941 )
2016
28
Clinical Profile of Scrub Typhus in Pregnancy in Sub-Himalayan Region. ( 27651583 )
2016
29
Diagnostic evaluation of rapid tests for scrub typhus in the Indian population is needed. ( 27169486 )
2016
30
Aftershocks of scrub typhus in Nepal. ( 27633427 )
2016
31
Evolution of Eschar in Scrub Typhus. ( 27928073 )
2016
32
Molecular characterization of Orientia tsutsugamushi serotypes causing scrub typhus outbreak in southern region of Andhra Pradesh, India. ( 28256470 )
2016
33
Determination of Cutoff of ELISA and Immunofluorescence Assay for Scrub Typhus. ( 27621559 )
2016
34
Scrub typhus in hilly regions of north east India. ( 27834339 )
2016
35
Acute respiratory failure in scrub typhus patients. ( 27630462 )
2016
36
A Case of Scrub Typhus Complicated by Adult Respiratory Distress Syndrome and Successful Management with Extracorporeal Membrane Oxygenation. ( 27458040 )
2016
37
Scrub Typhus. ( 27208218 )
2016
38
Serological Diagnosis of Acute Scrub Typhus in Southern India: Evaluation of InBios Scrub Typhus Detect IgM Rapid Test and Comparison with other Serological Tests. ( 28050364 )
2016
39
Scrub typhus masquerading as HELLP syndrome and puerperal sepsis in an asymptomatic malaria patient. ( 27413718 )
2016
40
Scrub typhus with hyperacusis and tinnitus. ( 27728719 )
2016
41
Scrub typhus: Experience in management of cases with pulmonary involvement in critical care unit. ( 27076739 )
2016
42
Seroprevalence of Scrub Typhus Infection in Arunachal Pradesh, India. ( 27536803 )
2016
43
Epidemiology & risk factors of scrub typhus in south India. ( 27834329 )
2016
44
Spatiotemporal Dynamics of Scrub Typhus Transmission in Mainland China, 2006-2014. ( 27479297 )
2016
45
A comparative evaluation of the serological and molecular methods for the diagnosis of scrub typhus in Indian settings. ( 27580576 )
2016
46
Analysis of scrub typhus involvement of the lung by bronchoalveolar lavage: A case report. ( 27886863 )
2016
47
The Rapid Effectiveness of Minocycline against Scrub Typhus Meningoencephalitis. ( 27041169 )
2016
48
Eschar: A Stepping Stone to Scrub Typhus. ( 27908651 )
2016
49
An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection. ( 27479584 )
2016
50
Characteristics of Pediatric Scrub Typhus Eschar in South Indian Children. ( 27981627 )
2016

Variations for Scrub Typhus

Expression for Scrub Typhus

Search GEO for disease gene expression data for Scrub Typhus.

Pathways for Scrub Typhus

GO Terms for Scrub Typhus

Cellular components related to Scrub Typhus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CD40LG CRP F3 GPT IL10 IL1B

Biological processes related to Scrub Typhus according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CD40LG IL10 IL1B TLR4
2 B cell proliferation GO:0042100 9.54 CD40LG IL10
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.54 CD40LG IL1B TLR4
4 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 IL1B TLR4
5 negative regulation of interferon-gamma production GO:0032689 9.51 IL10 TLR4
6 positive regulation of interleukin-8 production GO:0032757 9.49 IL1B TLR4
7 negative regulation of interleukin-6 production GO:0032715 9.48 IL10 TLR4
8 positive regulation of interleukin-10 production GO:0032733 9.46 CD40LG TLR4
9 response to lipopolysaccharide GO:0032496 9.46 IDO1 IL10 IL1B TLR4
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.4 IL1B TLR4
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 IL10 IL1B
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.26 IL10 TLR4
13 positive regulation of interleukin-12 production GO:0032735 9.13 CD40LG IDO1 TLR4
14 inflammatory response GO:0006954 9.1 CD40LG CRP IDO1 IL10 IL1B TLR4

Molecular functions related to Scrub Typhus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CD40LG IL10 IL1B

Sources for Scrub Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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