MCID: SSN001
MIFTS: 51

Seasonal Affective Disorder malady

Summaries for Seasonal Affective Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards: Seasonal Affective Disorder, also known as winter depression, is related to sleep disorder and bipolar disorder. An important gene associated with Seasonal Affective Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Serotonin Receptor 2 and ELK-SRF/GATA4 signaling and Circadian Repression of Expression by REV-ERBA. The compounds gnrh and antidepressants have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:8 A mental depression that involves presentation of depressive symptoms only during a specific season of the year.

Wikipedia:64 Seasonal affective disorder (SAD), also known as winter depression, winter blues, summer depression,... more...

Description from OMIM:47 608516

Aliases & Classifications for Seasonal Affective Disorder

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Aliases & Descriptions:

seasonal affective disorder 8 47 45 34 61
winter depression 8 61


External Ids:

Disease Ontology8 DOID:0060167

Related Diseases for Seasonal Affective Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Seasonal Affective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder30.9CLOCK
2bipolar disorder30.7HTR2A, SLC6A4
3bulimia nervosa30.4SLC6A4, NPY, HTR2A
4chronic fatigue syndrome30.4SLC6A4, POMC, CRH, HTR1A
5obsessive-compulsive disorder30.3TPH1, SLC6A4, DRD4, HTR2A, HTR1A
6anxiety disorder30.3TPH1, SLC6A4, CRH, GABBR1, GAL, NPY
7conduct disorder30.1DRD4, SLC6A4
8autistic disorder30.1HTR1A, HTR2A, SLC6A4
9melancholia30.1POMC, CRH
10delayed sleep phase syndrome30.1CLOCK, PER3
11attention deficit hyperactivity disorder30.1TPH1, SLC6A4, DRD4, HTR2A, HTR2C
12panic disorder30.1HTR1A, CRH, POMC, SLC6A4
13anorexia nervosa30.0TPH1, SLC6A4, POMC, PRL, CRH, GAL
14adjustment disorder10.2
15pain disorder10.2
16bipolar i disorder10.2
17major depressive disorder10.1
18multiple chemical sensitivity10.1
19neurotic disorder10.1
20atypical depressive disorder10.1
21trichotillomania10.1
22n syndrome10.1
23brain injury10.1
24hypersomnia10.1
25spinal cord injury10.1
26heroin dependence10.0DRD4
27drug dependence10.0SLC6A4
28neuroleptic malignant syndrome10.0HTR1A
29cocaine abuse10.0SLC6A4
30alcoholic psychosis10.0SLC6A4
31borderline personality disorder10.0TPH1, SLC6A4
32acute myocardial infarction10.0SLC6A4, HTR2A
33antisocial personality disorder10.0HTR2A, SLC6A4
34premature ejaculation10.0SLC6A4, HTR1A
35nicotine dependence10.0SLC6A4, DRD4
36serotonin syndrome10.0HTR1A, HTR2A
37generalized anxiety disorder10.0HTR1A, SLC6A4
38down syndrome10.0GAL, HTR1A
39alcohol abuse10.0SLC6A4, GAL
40constipation10.0SLC6A4
41hepatitis10.0GAL
42endogenous depression10.0CRH, SLC6A4
43social phobia10.0SLC6A4, HTR1A
44cyclothymic disorder10.0HTR2C, HTR2A
45substance abuse10.0SLC6A4, CRH, DRD4
46hypokalemia10.0POMC
47personality disorder10.0TPH1, SLC6A4, DRD4
48paraganglioma10.0GAL
49irritable bowel syndrome10.0CRH, SLC6A4, TPH1
50pathological gambling10.0DRD4

Graphical network of the top 20 diseases related to Seasonal Affective Disorder:



Diseases related to seasonal affective disorder

Clinical Features for Seasonal Affective Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608516

Drugs & Therapeutics for Seasonal Affective Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Seasonal Affective Disorder

Drug clinical trials:

Search ClinicalTrials for Seasonal Affective Disorder

Search NIH Clinical Center for Seasonal Affective Disorder

Search CenterWatch for Seasonal Affective Disorder

Genetic Tests for Seasonal Affective Disorder

Anatomical Context for Seasonal Affective Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Seasonal Affective Disorder:

33
Skin, Spinal cord, Brain, Retina, Thyroid, Salivary gland, Adrenal gland, T cells, Pineal, Pituitary

Animal Models for Seasonal Affective Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Seasonal Affective Disorder

Sources:
51PubMed
See all sources

Articles related to Seasonal Affective Disorder:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Are you SAD? Recognizing seasonal affective disorder. (21329283)
2010
2
Report of two double-blind randomized placebo-controlled pilot studies of a carbohydrate-rich nutrient mixture for treatment of seasonal affective disorder (SAD). (19769596)
2010
3
Narrow-band blue-light treatment of seasonal affective disorder in adults and the influence of additional nonseasonal symptoms. (19016463)
2009
4
The prevalence of seasonal affective disorder (SAD) in Greenland is related to latitude. (19306154)
2009
5
Season of birth in siblings of patients with seasonal affective disorder. A test of the parental conception habits hypothesis. (17902009)
2007
6
Long-term and preventative treatment for seasonal affective disorder. (17927295)
2007
7
A randomized controlled trial of cognitive-behavioral therapy, light therapy, and their combination for seasonal affective disorder. (17563165)
2007
8
A pilot study of adherence with light treatment for seasonal affective disorder. (17161464)
2007
9
Seasonal affective disorder. (17111890)
2006
10
Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism. (14744475)
2004
11
Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder. (14560322)
2004
12
Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder. (12167522)
2002
13
Depressive symptomatology differentiates subgroups of patients with seasonal affective disorder. (11816051)
2002
14
Changes of clinical pattern in seasonal affective disorder (SAD) over time in a German-speaking sample. (12111337)
2002
15
Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls. (11722161)
2001
16
Reboxetine in seasonal affective disorder: an open trial. (11226806)
2001
17
Seasonality, social zeitgebers and mood variability in entrainment of mood. Implications for seasonal affective disorder. (10814770)
2000
18
Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission. (10722178)
2000
19
Pathophysiology of seasonal affective disorder: a review. (11109298)
2000
20
Dose-response relationship of phototherapy for seasonal affective disorder: a meta-analysis. (10353446)
1999
21
Update on seasonal affective disorder (SAD). (11042997)
1999
22
Efficacy of light versus tryptophan therapy in seasonal affective disorder. (9716275)
1998
23
Psoralens in association with seasonal affective disorder. (9710320)
1998
24
Seasonal affective disorder. (9802288)
1998
25
Eating style in seasonal affective disorder: who will gain weight in winter? (9056125)
1997
26
L-tryptophan augmentation of light therapy in patients with seasonal affective disorder. (9114947)
1997
27
Rapid tryptophan depletion in drug-free depressed patients with seasonal affective disorder. (9247407)
1997
28
Two naturally occurring amino acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls. (8959291)
1996
29
Effects of bright light on sleepiness, melatonin, and 25-hydroxyvitamin D(3) in winter seasonal affective disorder. (9172707)
1996
30
Subsyndromal seasonal affective disorder in Antarctica. (8831642)
1996
31
'Natural' light treatment of seasonal affective disorder. (8731073)
1996
32
Side effects related to light therapy in seasonal affective disorder. (8166333)
1994
33
Pain and seasonal affective disorder. (8199805)
1994
34
Relationship between cognitive sensitivity to (symbolic) light in remitted seasonal affective disorder patients and the onset time of a subsequent depressive episode. (8046159)
1994
35
A simple portable ocular light device for phototherapy of seasonal affective disorder. (7833983)
1994
36
Sleep in fall/winter seasonal affective disorder: effects of light and changing seasons. (8064650)
1994
37
A photobiological evaluation of lamps used in the phototherapy of seasonal affective disorder. (8459321)
1993
38
Seasonal affective disorder: lower or raised resting metabolic rate? (8377675)
1993
39
Frequency of seasonal affective disorder among individuals seeking treatment at a northern Canadian mental health center. (8464954)
1993
40
Seasonal affective disorder: the hidden benefits. (8109694)
1993
41
Light visor treatment for seasonal affective disorder: a multicenter study. (8464953)
1993
42
Light therapy in seasonal affective disorder is independent of time of day or circadian phase. (8250678)
1993
43
Predictors of response to phototherapy in seasonal affective disorder. (1544295)
1992
44
Ultraviolet versus non-ultraviolet light therapy for seasonal affective disorder. (2033028)
1991
45
Tryptophan treatment and melatonin response in a patient with seasonal affective disorder. (2040722)
1991
46
Phototherapeutic response variability in seasonal affective disorder. (1869498)
1991
47
Nursing students' anticipation of experiencing symptoms of seasonal affective disorder. (2087390)
1990
48
Seasonal affective disorder. (2622845)
1989
49
Geophysical variables and behavior: LVII. Seasonal affective disorder and phototherapy. (2664847)
1989
50
Why not treat melancholia with melatonin and tryptophan and treat seasonal affective disorders with bright light? (3226357)
1988

Genetic Variations for Seasonal Affective Disorder

Expression for genes affiliated with Seasonal Affective Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Seasonal Affective Disorder

Search GEO for disease gene expression data for Seasonal Affective Disorder.

Pathways for genes affiliated with Seasonal Affective Disorder

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 50PharmGKB, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9HTR2A, HTR2C
29.6CLOCK, NPAS2
39.6CLOCK, NPAS2
49.6NPAS2, CLOCK
59.6POMC, CRH
69.4SLC6A4, GABBR1, GNB3
79.4CRH, GABBR1, GAL
8
Hide members
9.3PER3, CLOCK, NPAS2
9
Hide members
9.3GNB3, HTR2C, HTR2A, OPN4
109.2TPH1, SLC6A4, HTR2A, HTR1A, GNB3
11
Hide members
9.1HTR2C, HTR1A, HTR2A, DRD4, SLC6A4
128.3GNB3, HTR1A, NPY, GABBR1, TPH1
13
Hide members
7.5GNB3, HTR2C, HTR1A, HTR2A, DRD4, GABBR1
14
Hide members
5.7POMC, GNB3, HTR2C, HTR1A, HTR2A, NPY
15
Hide members
5.7NPY, HTR2A, HTR1A, HTR2C, GNB3, DRD4

Compounds for genes affiliated with Seasonal Affective Disorder

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 280)
idCompoundScoreTop Affiliating Genes
1gnrh4510.0GAL, GABBR1
2antidepressants509.5GNB3, TPH1, HTR2A, HTR1A, GAL
3fluvoxamine45 50 1111.3HTR2A, TPH1, CLOCK, HTR1A, SLC6A4
4pindolol45 29 1111.2HTR1A, HTR2A, PRL, SLC6A4
5m-chlorophenylpiperazine459.2HTR2C, SLC6A4, PRL, HTR2A, HTR1A
6mcpp459.2SLC6A4, HTR2A, HTR1A, HTR2C, PRL
7terguride29 4510.2HTR2A, HTR2C, HTR1A, PRL, DRD4
8paroxetine45 50 29 1112.2HTR2A, HTR1A, TPH1, SLC6A4, PRL, DRD4
95-hydroxytryptophan459.2TPH1, SLC6A4, PRL, CRH, HTR2A, HTR1A
10lisuride29 45 1111.2PRL, HTR2C, HTR2A, HTR1A, DRD4
11paliperidone45 1110.2DRD4, HTR2C, HTR2A, PRL, HTR1A
12pergolide29 45 1111.1HTR2C, PRL, HTR2A, DRD4, HTR1A
13pramipexole45 50 29 1112.1HTR1A, HTR2A, DRD4, PRL, HTR2C
14flesinoxan459.1HTR2A, POMC, PRL, HTR1A
15roxindole29 4510.1DRD4, HTR2A, HTR1A, HTR2C
16cabergoline29 45 1111.0HTR1A, HTR2C, HTR2A, DRD4, PRL
17citalopram50 45 11 2412.0HTR2C, HTR2A, PRL, TPH1, HTR1A, SLC6A4
18aripiprazole29 50 45 11 2413.0PRL, HTR2C, DRD4, HTR2A, HTR1A
19clomipramine45 50 1111.0CRH, SLC6A4, HTR2A, HTR1A, HTR2C, PRL
20ziprasidone50 29 45 1112.0PRL, DRD4, HTR2A, HTR1A, HTR2C
21risperidone29 45 50 60 11 2414.0HTR1A, HTR2A, DRD4, PRL, SLC6A4, HTR2C
22olanzapine50 45 29 11 2412.9PRL, GNB3, DRD4, HTR2A, HTR2C, HTR1A
23apomorphine45 29 1110.9HTR1A, HTR2C, PRL, HTR2A, DRD4
24ipsapirone45 299.9HTR1A, HTR2A, PRL, POMC, HTR2C
25quetiapine45 50 29 11 2412.8DRD4, PRL, HTR2C, HTR1A, HTR2A
26mhpg458.7CRH, DRD4, NPY, SLC6A4, PRL
27maoa458.7TPH1, SLC6A4, HTR2C, HTR1A, HTR2A, DRD4
28bromocriptine29 45 1110.7DRD4, POMC, HTR1A, HTR2C, PRL, HTR2A
29yohimbine45 29 2 1111.6HTR2C, CRH, NPY, HTR2A, HTR1A
30sulpiride45 29 1110.6HTR2C, NPY, DRD4, PRL, CRH
31fluoxetine50 45 29 1111.5GNB3, HTR2C, HTR1A, HTR2A, SLC6A4, PRL
32melatonin45 60 29 11 2412.4HTR2C, CLOCK, GAL, TPH1, PRL, OPN4
33topiramate45 11 2410.4CRH, POMC, GAL, NPY, HTR2C
34mirtazapine50 45 1110.3GAL, CRH, PRL, POMC, SLC6A4, HTR2A
35clozapine45 29 50 1111.1SLC6A4, POMC, DRD4, HTR1A, HTR2A, PRL
36haloperidol45 29 2 50 1112.0NPY, DRD4, HTR2A, HTR1A, SLC6A4, POMC
37amphetamine45 118.9SLC6A4, POMC, GABBR1, NPY, GAL, TPH1
38catecholamine457.8POMC, TPH1, CRH, GABBR1, NPY, DRD4
39corticosterone45 60 249.8GAL, NPY, HTR1A, CRH, PRL, POMC
40opiate457.6GAL, NPY, GABBR1, PRL, CRH, POMC
41clonidine45 29 119.5GAL, GABBR1, POMC, PRL, NPY, SLC6A4
42epinephrine45 11 249.5GAL, SLC6A4, GNB3, POMC, PRL, NPY
43fenfluramine29 45 119.3HTR1A, HTR2C, HTR2A, NPY, TPH1, SLC6A4
44gaba457.2NPY, GABBR1, DRD4, GAL, HTR2C, CRH
45acetylcholine45 50 29 11 2411.2NPY, HTR2C, HTR1A, TPH1, POMC, CRH
46adenylate457.0HTR1A, GABBR1, OPN4, CRH, POMC, HTR2C
47cocaine45 118.0HTR2C, NPY, DRD4, GAL, GABBR1, CRH
485-hydroxytryptamine456.3TPH1, SLC6A4, POMC, PRL, CRH, GABBR1
49norepinephrine45 11 248.0DRD4, NPY, HTR2A, HTR1A, HTR2C, GNB3
50dopamine45 29 11 248.5TPH1, GNB3, HTR2C, HTR1A, HTR2A, NPY

GO Terms for genes affiliated with Seasonal Affective Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.7POMC, PRL, GAL
2integral to plasma membraneGO:0058878.6SLC6A4, GABBR1, DRD4, HTR2A, HTR1A, HTR2C

Biological processes related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR2A, HTR1A
2regulation of serotonin secretionGO:01406210.2HTR1A, CRH
3response to immobilization stressGO:03590210.2CRH, TPH1
4regulation of dopamine metabolic processGO:04205310.2HTR1A, DRD4
5phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2C, HTR2A
6positive regulation of phosphatidylinositol biosynthetic processGO:01051310.1HTR2C, HTR2A
7regulation of behaviorGO:05079510.0HTR1A, HTR2A
8vasoconstrictionGO:04231010.0SLC6A4, HTR1A
9serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR1A, HTR2C
10synaptic transmission, dopaminergicGO:0019639.9DRD4, CRH
11behavioral fear responseGO:0016629.9DRD4, HTR1A, HTR2C
12parturitionGO:0075679.8PRL, CRH
13cellular calcium ion homeostasisGO:0068749.7DRD4, HTR2A, HTR2C
14regulation of appetiteGO:0320989.6POMC, HTR2C
15circadian rhythmGO:0076239.0TPH1, PER3, SLC6A4, CLOCK, PRL
16feeding behaviorGO:0076319.0HTR2C, NPY, GAL, CRH
17regulation of blood pressureGO:0082178.9POMC, NPY, GNB3
18response to drugGO:0424938.8HTR2C, HTR2A, GAL, CRH, PRL, SLC6A4
19neuropeptide signaling pathwayGO:0072188.4POMC, GAL, NPY
20synaptic transmissionGO:0072688.2GNB3, HTR2C, HTR2A, NPY, GABBR1, CRH

Molecular functions related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
11-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.9HTR2A, HTR2C
2serotonin receptor activityGO:0049939.7HTR2A, HTR1A, HTR2C
3drug bindingGO:0081449.6HTR2C, HTR2A, DRD4
4serotonin bindingGO:0513789.6HTR2C, HTR2A
5neuropeptide hormone activityGO:0051849.2CRH, GAL, NPY
6hormone activityGO:0051799.1POMC, PRL, CRH
7signal transducer activityGO:0048718.9PER3, CLOCK, NPAS2, GNB3

Products for genes affiliated with Seasonal Affective Disorder

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Sources for Seasonal Affective Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet