MCID: SSN001
MIFTS: 56

Seasonal Affective Disorder malady

Mental diseases category
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Summaries for Seasonal Affective Disorder

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards: Seasonal Affective Disorder, also known as winter depression, is related to chronic fatigue syndrome and bulimia nervosa. An important gene associated with Seasonal Affective Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. The compounds antidepressants and flesinoxan have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and skin, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Disease Ontology:8 A mental depression that involves presentation of depressive symptoms only during a specific season of the year.

Wikipedia:65 Seasonal affective disorder (SAD), also known as winter depression, winter blues, summer depression,... more...

Description from OMIM:47 608516

Aliases & Classifications for Seasonal Affective Disorder

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8Disease Ontology, 47OMIM, 45Novoseek, 34MedlinePlus, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

seasonal affective disorder 8 47 45 34 62
winter depression 8 62


External Ids:

Disease Ontology8 DOID:0060167

Related Diseases for Seasonal Affective Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Seasonal Affective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome30.5SLC6A4, POMC, CRH, HTR1A
2bulimia nervosa30.5SLC6A4, NPY, HTR2A
3personality disorder30.5TPH1, DRD4, SLC6A4
4obsessive-compulsive disorder30.4TPH1, HTR1A, DRD4, SLC6A4, HTR2A
5bipolar disorder30.3HTR2A, SLC6A4
6attention deficit hyperactivity disorder30.2SLC6A4, HTR2A, DRD4
7melancholia30.2POMC, CRH
8delayed sleep phase syndrome30.2CLOCK, PER3
9panic disorder30.2HTR1A, CRH, POMC, SLC6A4
10eating disorder30.0GAL, HTR2A, HTR1A, CRH, SLC6A4, NPY
11obesity29.9DRD4, NPY, GNB3, POMC, HTR2A, CLOCK
12anorexia nervosa29.7HTR2C, HTR2A, SLC6A4, NPY, GAL, DRD4
13mood disorder29.6GNB3, POMC, SLC6A4, NPY, GABBR1, GAL
14thyroiditis10.4
15cerebritis10.4
16blindness10.3
17retinitis10.2
18pathological gambling10.1DRD4
19neuroleptic malignant syndrome10.1HTR1A
20alcoholic psychosis10.1SLC6A4
21oppositional defiant disorder10.1DRD4
22pervasive developmental disorder10.1SLC6A4
23antisocial personality disorder10.1HTR2A, SLC6A4
24premature ejaculation10.1HTR1A, SLC6A4
25serotonin syndrome10.1HTR1A, HTR2A
26generalized anxiety disorder10.1SLC6A4, HTR1A
27endogenous depression10.1CRH, SLC6A4
28social phobia10.1HTR1A, SLC6A4
29adrenal carcinoma10.1POMC
30borderline personality disorder10.1SLC6A4, TPH1
31conduct disorder10.1DRD4, SLC6A4
32substance dependence10.1SLC6A4, DRD4, TPH1
33anxiety disorder10.1SLC6A4, CRH, TPH1
34irritable bowel syndrome10.1TPH1, SLC6A4, CRH
35autistic disorder10.1HTR1A, HTR2A, SLC6A4
36substance abuse10.1DRD4, SLC6A4, CRH
37cyclothymic disorder10.1HTR2A, HTR2C
38withdrawal disorder10.1GABBR1, CRH
39gonadal disease10.1CRH, POMC
40cushing's syndrome10.1CRH, POMC
41amnestic disorder10.1HTR1A, POMC
42gastrointestinal system disease10.1TPH1, CRH
43hypothalamic disease10.1CRH, PRL
44hypoadrenalism10.1CRH, POMC
45infantile epileptic encephalopathy10.1POMC, CRH
46major depressive disorder10.1
47multiple chemical sensitivity10.1
48trichotillomania10.1
49learning disability10.1
50brain injury10.1

Graphical network of the top 20 diseases related to Seasonal Affective Disorder:



Diseases related to seasonal affective disorder

Symptoms for Seasonal Affective Disorder

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47OMIM
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Clinical features from OMIM:

608516

Drugs & Therapeutics for Seasonal Affective Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Seasonal Affective Disorder

Search NIH Clinical Center for Seasonal Affective Disorder

Genetic Tests for Seasonal Affective Disorder

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Anatomical Context for Seasonal Affective Disorder

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33MalaCards
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MalaCards organs/tissues related to Seasonal Affective Disorder:

33
Brain, Thyroid, Skin, Testes, Eye, Bone, Spinal cord, T cells, Retina, Pineal, Pituitary

Animal Models for Seasonal Affective Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Seasonal Affective Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4PRL, HTR2A, CRH, GAL, SLC6A4, POMC
2MP:00053757.4TPH1, POMC, CLOCK, HTR2C, GABBR1, NPY
3MP:00107716.9TPH1, POMC, CLOCK, PRL, HTR2C, CRH
4MP:00053786.3TPH1, POMC, CLOCK, HTR2C, CRH, GAL
5MP:00053765.1HTR1A, HTR2C, PRL, CLOCK, POMC, TPH1
6MP:00036314.6HTR2C, PRL, CLOCK, POMC, GNB3, PER3
7MP:00053864.5SLC6A4, PER3, TPH1, POMC, CLOCK, PRL

Publications for Seasonal Affective Disorder

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Sources:
52PubMed
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Articles related to Seasonal Affective Disorder:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
Altered resting-state activity in seasonal affective disorder. (22987670)
2014
2
Can transcranial brain-targeted bright light treatment via ear canals be effective in relieving symptoms in seasonal affective disorder? A pilot study. (22296809)
2012
3
Are you SAD? Recognizing seasonal affective disorder. (21329283)
2010
4
A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (18804284)
2009
5
Escitalopram in seasonal affective disorder: results of an open trial. (17327956)
2007
6
Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder. (17151164)
2006
7
What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)? (15645001)
2005
8
Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy. (12586452)
2003
9
Evidence supports validity of seasonal affective disorder. (12420659)
2002
10
Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. (11910270)
2002
11
Genetics of seasonal affective disorder. (11897319)
2002
12
Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? (12103471)
2002
13
Seasonal affective disorder in an Arctic community. (11942945)
2002
14
Monoaminergic function in the pathogenesis of seasonal affective disorder. (11806867)
2001
15
Possible genetic link between seasonal affective disorder and eating disorders. (11291638)
2001
16
Seasonality, social zeitgebers and mood variability in entrainment of mood. Implications for seasonal affective disorder. (10814770)
2000
17
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
18
Accelerated post-glucose glycaemia and altered alliesthesia-test in Seasonal Affective Disorder. (10363663)
1999
19
Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A. (10089016)
1999
20
The prevalence of seasonal affective disorder in The Netherlands: a prospective and retrospective study of seasonal mood variation in the general population. (10386184)
1999
21
Winter and summer outdoor light exposure in women with and without seasonal affective disorder. (10701473)
1999
22
Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. (9577843)
1998
23
Case study: dawn simulation as maintenance treatment in a nine-year-old patient with seasonal affective disorder. (9735618)
1998
24
Suicide after bright light treatment in seasonal affective disorder: a case report. (9771819)
1998
25
Effects of fluoxetine versus bright light in the treatment of seasonal affective disorder. (9723147)
1998
26
Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms. (9107154)
1997
27
Eating style in seasonal affective disorder: who will gain weight in winter? (9056125)
1997
28
L-tryptophan augmentation of light therapy in patients with seasonal affective disorder. (9114947)
1997
29
Suicidal tendencies as a complication of light therapy for seasonal affective disorder: a report of three cases. (9378689)
1997
30
Seasonal affective disorder in Australia: is photoperiod critical? (9140637)
1997
31
School and seasonal affective disorder. (8633723)
1996
32
Seasonal affective disorder in a tropical country: a case report. (7792337)
1995
33
Multicenter, placebo-controlled study of fluoxetine in seasonal affective disorder. (8526243)
1995
34
A longitudinal follow-up study of seasonal affective disorder. (7755115)
1995
35
Influence of phototherapy treatment duration for seasonal affective disorder: outcome at one vs. two weeks. (8580228)
1995
36
Estrogen could control photoperiodic adjustment in seasonal affective disorder. (8524174)
1995
37
Olfactory function in winter seasonal affective disorder. (7573599)
1995
38
Seasonal affective disorder: are the DSM-III-R criteria valid? (7846253)
1994
39
Multiple chemical sensitivity: lessons from seasonal affective disorder. (7778119)
1994
40
Onset of depressive episodes in a woman with seasonal affective disorder of "spring type" coincident with atmospheric temperature, but not with sunshine duration. (8201789)
1993
41
Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder. (8127946)
1993
42
Predictors of response to phototherapy in seasonal affective disorder. (1544295)
1992
43
Defining seasonal affective disorder(s) (1391279)
1992
44
A seasonal depression. Management of seasonal affective disorder. (1465471)
1992
45
Uncommon disorders. Summer seasonal affective disorder. (1503943)
1992
46
Diurnal variation of symptoms in seasonal affective disorder. (1862158)
1991
47
Prolactin levels in women with seasonal affective disorder. (2343937)
1990
48
Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. (2497477)
1989
49
Ophthalmic implications of seasonal affective disorder. (2668388)
1989
50
Seasonal affective disorder. (2622845)
1989

Variations for Seasonal Affective Disorder

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Expression for genes affiliated with Seasonal Affective Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seasonal Affective Disorder

Search GEO for disease gene expression data for Seasonal Affective Disorder.

Pathways for genes affiliated with Seasonal Affective Disorder

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 12EMD Millipore, 53QIAGEN, 30KEGG, 5Cell Signaling Technology
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Pathways related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8POMC, CRH
29.7HTR2C, HTR2A
3
Show member pathways
9.6GNB3, GABBR1, SLC6A4
49.5NPAS2, CLOCK
59.5NPAS2, CLOCK
69.5GABBR1, GAL, CRH
79.5GNB3, POMC, CRH
89.5CRH, POMC, GNB3
9
Show member pathways
9.4HTR2C, HTR2A, GNB3
10
Show member pathways
9.3DRD4, HTR1A, HTR2C, HTR2A
119.2GNB3, TPH1, HTR2A, HTR1A, SLC6A4
12
Show member pathways
9.2GNB3, HTR2A, HTR2C, HTR1A
13
Show member pathways
9.2GNB3, HTR2A, HTR2C, OPN4
14
Show member pathways
9.1NPAS2, CLOCK, PER3
159.0TPH1, HTR2A, HTR2C, HTR1A, SLC6A4
168.5GNB3, TPH1, HTR1A, GABBR1, NPY
17
Show member pathways
7.9GNB3, CLOCK, PRL, CRH, NPY
18
Show member pathways
7.1GABBR1, DRD4, HTR1A, HTR2C, HTR2A, CLOCK
19
Show member pathways
5.9HTR2C, HTR2A, PRL, POMC, GNB3, HTR1A
20
Show member pathways
5.9NPY, GNB3, POMC, OPN4, GABBR1, GAL

Compounds for genes affiliated with Seasonal Affective Disorder

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Sources:
51PharmGKB, 45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 294)
idCompoundScoreTop Affiliating Genes
1antidepressants519.4TPH1, HTR2A, GAL, GNB3, HTR1A
2flesinoxan459.2PRL, HTR2A, HTR1A, POMC
35-hydroxytryptophan459.2PRL, HTR1A, CRH, SLC6A4, TPH1, HTR2A
4paroxetine45 51 29 1112.2PRL, TPH1, HTR2A, DRD4, SLC6A4, HTR1A
5m-chlorophenylpiperazine459.1HTR2A, HTR2C, HTR1A, SLC6A4, PRL
6mcpp459.1SLC6A4, PRL, HTR2A, HTR1A, HTR2C
7fluvoxamine45 51 1111.1TPH1, CLOCK, HTR2A, HTR1A, SLC6A4
8terguride45 2910.1HTR1A, PRL, HTR2A, DRD4, HTR2C
9selective serotonin reuptake inhibitors519.1SLC6A4, GAL, HTR2A, HTR1A
10lisuride45 29 1111.0DRD4, HTR1A, HTR2C, PRL, HTR2A
11paliperidone45 1110.0PRL, HTR2A, DRD4, HTR2C, HTR1A
12pergolide45 29 1111.0PRL, HTR2A, HTR2C, HTR1A, DRD4
13pramipexole45 29 51 1112.0PRL, HTR2A, HTR2C, HTR1A, DRD4
14ipsapirone45 299.9POMC, PRL, HTR2A, HTR2C, HTR1A
15cabergoline45 29 1110.9PRL, HTR2A, HTR2C, HTR1A, DRD4
16clomipramine45 51 1110.9CRH, SLC6A4, HTR1A, HTR2C, HTR2A, PRL
17quetiapine45 51 29 24 1112.9PRL, DRD4, HTR2A, HTR1A, SLC6A4, HTR2C
18aripiprazole29 45 51 24 1112.9HTR1A, PRL, DRD4, HTR2C, HTR2A
19risperidone45 51 29 61 24 1113.8PRL, SLC6A4, DRD4, HTR1A, HTR2C, HTR2A
20ziprasidone29 51 45 1111.8HTR1A, HTR2C, DRD4, PRL, HTR2A
21maoa458.8SLC6A4, TPH1, POMC, HTR2A, HTR2C, HTR1A
22mhpg458.7NPY, PRL, CRH, SLC6A4, DRD4
23citalopram45 51 24 1111.7SLC6A4, HTR1A, HTR2C, CRH, HTR2A, PRL
24apomorphine29 45 1110.6HTR2C, PRL, HTR1A, DRD4, HTR2A
25olanzapine45 51 29 24 1112.6HTR2C, HTR1A, HTR2A, DRD4, GNB3, PRL
26sulpiride45 29 1110.4DRD4, NPY, CRH, HTR2C, PRL
27yohimbine45 3 29 1111.4HTR1A, NPY, CRH, HTR2C, HTR2A
28fluoxetine45 51 29 1111.4SLC6A4, CRH, HTR1A, HTR2C, GNB3, TPH1
29bromocriptine45 29 1110.4POMC, PRL, HTR2A, HTR2C, HTR1A, DRD4
30topiramate45 51 24 1111.3HTR2C, CRH, GAL, NPY, POMC
31mirtazapine45 51 1110.3SLC6A4, GAL, CRH, HTR2C, HTR2A, PRL
32amphetamine45 51 1110.2NPY, TPH1, POMC, DRD4, GAL, GABBR1
33clozapine45 29 51 1111.2DRD4, HTR1A, HTR2C, HTR2A, PRL, POMC
34catecholamine458.1NPY, GABBR1, GAL, DRD4, CRH, POMC
35haloperidol45 51 29 3 1112.1PRL, DRD4, HTR2A, HTR1A, POMC, NPY
36melatonin45 29 61 24 1112.1GAL, PRL, CLOCK, TPH1, OPN4, DRD4
37corticosterone45 61 249.9PRL, HTR1A, CRH, GAL, NPY, POMC
38opiate457.8CRH, POMC, SLC6A4, PRL, NPY, GABBR1
39clonidine45 51 29 1110.8POMC, GAL, GABBR1, NPY, SLC6A4, PRL
40epinephrine45 24 119.6PRL, CRH, POMC, DRD4, GAL, SLC6A4
41acetylcholine45 51 29 24 1111.5GAL, TPH1, POMC, HTR1A, HTR2C, CRH
42gaba457.4TPH1, POMC, HTR2C, SLC6A4, DRD4, CRH
43fenfluramine45 29 119.4POMC, NPY, SLC6A4, CRH, PRL, HTR2A
44gnrh457.3GAL, POMC, PRL, HTR2C, CRH, GABBR1
45adenylate457.2GABBR1, CRH, NPY, HTR1A, HTR2C, POMC
46glutamate457.2SLC6A4, NPY, OPN4, GABBR1, GAL, DRD4
47cocaine45 118.1CRH, DRD4, GAL, GABBR1, NPY, POMC
485-hydroxytryptamine456.4SLC6A4, NPY, GABBR1, GAL, DRD4, CRH
49norepinephrine45 24 118.2POMC, TPH1, GNB3, HTR2C, SLC6A4, NPY
50dopamine45 29 24 118.5HTR2A, PRL, CLOCK, POMC, TPH1, GNB3

GO Terms for genes affiliated with Seasonal Affective Disorder

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16Gene Ontology
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Cellular components related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.7SLC6A4, TPH1, GNB3
2integral component of plasma membraneGO:0058878.7SLC6A4, GABBR1, DRD4, HTR1A, HTR2C, HTR2A
3plasma membraneGO:0058867.8GNB3, HTR2A, HTR2C, HTR1A, DRD4, GABBR1
4extracellular regionGO:0055767.6POMC, PRL, CRH, GAL, GABBR1, NPY

Biological processes related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR1A, HTR2A
2regulation of serotonin secretionGO:01406210.3CRH, HTR1A
3response to immobilization stressGO:03590210.2TPH1, CRH
4regulation of dopamine metabolic processGO:04205310.2DRD4, HTR1A
5synaptic transmission, dopaminergicGO:00196310.1DRD4, CRH
6regulation of behaviorGO:05079510.1HTR1A, HTR2A
7behavioral response to cocaineGO:04814810.1DRD4, HTR2A
8phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2C, HTR2A
9positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2A, HTR2C
10vasoconstrictionGO:04231010.0HTR1A, SLC6A4
11photoperiodismGO:0096489.9CLOCK, DRD4
12serotonin receptor signaling pathwayGO:0072109.8HTR2A, HTR2C, HTR1A
13behavioral fear responseGO:0016629.8HTR2C, HTR1A, DRD4
14cellular calcium ion homeostasisGO:0068749.7DRD4, HTR2C, HTR2A
15release of sequestered calcium ion into cytosolGO:0512099.7HTR2C, HTR2A
16regulation of appetiteGO:0320989.7POMC, HTR2C
17negative regulation of adenylate cyclase activityGO:0071949.6GABBR1, DRD4
18circadian rhythmGO:0076239.5TPH1, CLOCK, DRD4, SLC6A4
19circadian regulation of gene expressionGO:0329229.3CLOCK, PER3
20response to drugGO:0424939.2SLC6A4, GAL, CRH, HTR2C, HTR2A
21regulation of blood pressureGO:0082179.2NPY, POMC, GNB3
22neuropeptide signaling pathwayGO:0072189.0POMC, GAL, NPY
23feeding behaviorGO:0076318.9NPY, GAL, CRH, HTR2C
24synaptic transmissionGO:0072688.4NPY, GABBR1, CRH, HTR2C, HTR2A, GNB3

Molecular functions related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
11-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.9HTR2C, HTR2A
2serotonin bindingGO:0513789.7HTR2A, HTR2C
3serotonin receptor activityGO:0049939.7HTR1A, HTR2C, HTR2A
4drug bindingGO:0081449.6DRD4, HTR2C, HTR2A
5G-protein coupled receptor bindingGO:0016649.2NPY, POMC
6neuropeptide hormone activityGO:0051849.2CRH, GAL, NPY
7hormone activityGO:0051799.1CRH, PRL, POMC
8signal transducer activityGO:0048718.9PER3, GNB3, CLOCK, NPAS2
9protein bindingGO:0055156.6PER3, GNB3, CLOCK, PRL, HTR1A, CRH

Products for genes affiliated with Seasonal Affective Disorder

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Sources for Seasonal Affective Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet