MCID: SSN001
MIFTS: 53

Seasonal Affective Disorder malady

Summaries for Seasonal Affective Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards: Seasonal Affective Disorder, also known as winter depression, is related to sleep disorder and mood disorder. An important gene associated with Seasonal Affective Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Serotonin Receptor 2 and ELK-SRF/GATA4 signaling and Circadian Repression of Expression by REV-ERBA. The compounds gnrh and antidepressants have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and testes, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:8 A mental depression that involves presentation of depressive symptoms only during a specific season of the year.

Wikipedia:63 Seasonal affective disorder (SAD), also known as winter depression, winter blues, summer depression,... more...

Description from OMIM:46 608516

Aliases & Classifications for Seasonal Affective Disorder

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8Disease Ontology, 46OMIM, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

seasonal affective disorder 8 46 44 33 60
winter depression 8 60


External Ids:

Disease Ontology8 DOID:0060167

Related Diseases for Seasonal Affective Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Seasonal Affective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder30.8CLOCK
2mood disorder30.7GABBR1, GAL, DRD4, NPY, HTR2A, HTR1A
3personality disorder30.7TPH1, SLC6A4, DRD4
4bipolar disorder30.6HTR2A, SLC6A4
5thyroiditis30.5POMC
6eating disorder30.5HTR1A, HTR2A, NPY, GAL, CRH, SLC6A4
7bulimia nervosa30.4SLC6A4, NPY, HTR2A
8chronic fatigue syndrome30.4SLC6A4, POMC, CRH, HTR1A
9obsessive-compulsive disorder30.2TPH1, SLC6A4, DRD4, HTR2A, HTR1A
10anxiety disorder30.2TPH1, SLC6A4, CRH, GABBR1, GAL, NPY
11obesity30.2GNB3, HTR2C, HTR1A, HTR2A, NPY, DRD4
12conduct disorder30.0DRD4, SLC6A4
13autistic disorder30.0HTR1A, HTR2A, SLC6A4
14melancholia30.0POMC, CRH
15attention deficit hyperactivity disorder30.0TPH1, SLC6A4, DRD4, HTR2A, HTR2C
16panic disorder30.0HTR1A, CRH, POMC, SLC6A4
17anorexia nervosa30.0TPH1, SLC6A4, POMC, PRL, CRH, GAL
18cerebritis10.4
19major depressive disorder10.3
20atypical depressive disorder10.3
21adjustment disorder10.3
22somatization disorder10.2
23pain disorder10.2
24retinitis10.2
25multiple chemical sensitivity10.0
26trichotillomania10.0
27learning disability10.0
28vitamin metabolic disorder10.0
29heroin dependence10.0DRD4
30drug dependence10.0SLC6A4
31neuroleptic malignant syndrome10.0HTR1A
32cocaine abuse10.0SLC6A4
33alcoholic psychosis10.0SLC6A4
34borderline personality disorder10.0TPH1, SLC6A4
35acute myocardial infarction10.0SLC6A4, HTR2A
36antisocial personality disorder10.0HTR2A, SLC6A4
37premature ejaculation10.0SLC6A4, HTR1A
38nicotine dependence10.0SLC6A4, DRD4
39serotonin syndrome10.0HTR1A, HTR2A
40generalized anxiety disorder10.0HTR1A, SLC6A4
41down syndrome10.0GAL, HTR1A
42alcohol abuse10.0SLC6A4, GAL
43constipation10.0SLC6A4
44hepatitis10.0GAL
45endogenous depression10.0CRH, SLC6A4
46social phobia10.0SLC6A4, HTR1A
47cyclothymic disorder10.0HTR2C, HTR2A
48substance abuse10.0SLC6A4, CRH, DRD4
49hypokalemia10.0POMC
50paraganglioma10.0GAL

Graphical network of the top 20 diseases related to Seasonal Affective Disorder:



Diseases related to seasonal affective disorder

Clinical Features for Seasonal Affective Disorder

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46OMIM
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Clinical features from OMIM:

608516

Drugs & Therapeutics for Seasonal Affective Disorder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Seasonal Affective Disorder

Drug clinical trials:

Search ClinicalTrials for Seasonal Affective Disorder

Search NIH Clinical Center for Seasonal Affective Disorder

Search CenterWatch for Seasonal Affective Disorder

Genetic Tests for Seasonal Affective Disorder

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Anatomical Context for Seasonal Affective Disorder

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32MalaCards
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MalaCards organs/tissues related to Seasonal Affective Disorder:

32
Brain, Thyroid, Testes, Eye, Skin, Spinal cord, Bone, T cells, Pituitary, Retina, Pineal

Animal Models for Seasonal Affective Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Seasonal Affective Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053757.1HTR2C, NPY, GABBR1, POMC, CLOCK, TPH1
2MP:00107716.8HTR2C, GAL, GABBR1, CRH, PRL, POMC
3MP:00053786.6NPY, GAL, GABBR1, CRH, POMC, CLOCK
4MP:00053764.9GAL, DRD4, NPAS2, NPY, HTR1A, HTR2C
5MP:00036314.6DRD4, NPAS2, NPY, HTR1A, HTR2C, GNB3
6MP:00053864.5TPH1, HTR2C, HTR1A, HTR2A, NPY, NPAS2

Publications for Seasonal Affective Disorder

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50PubMed
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Articles related to Seasonal Affective Disorder:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Association between seasonal affective disorder and subjective quality of the sleep/wake cycle in adolescents. (24405784)
2013
2
The post illumination pupil response is reduced in seasonal affective disorder. (23809464)
2013
3
Improvement in Fatigue, Sleepiness, and Health-Related Quality of Life with Bright Light Treatment in Persons with Seasonal Affective Disorder and Subsyndromal SAD. (21747994)
2011
4
Second-generation antidepressants for seasonal affective disorder. (22161433)
2011
5
Atypical pattern of rod electroretinogram modulation by recent light history: a possible biomarker of seasonal affective disorder. (20832867)
2011
6
A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (18804284)
2009
7
Low serotonin levels and seasonal affective disorder. (19186305)
2009
8
What is this thing called "SAD"? A critique of the concept of Seasonal Affective Disorder. (18589628)
2008
9
Personality and seasonal affective disorder: results from the CAN-SAD study. (16647139)
2006
10
Dysfunctional attitudes in seasonal affective disorder. (16290816)
2006
11
The Seasonal Health Questionnaire is more effective at detecting seasonal affective disorder than the Seasonal Pattern Adjustment Questionnaire. (15273215)
2004
12
Treatment of seasonal affective disorder: unipolar versus bipolar differences. (15538998)
2004
13
A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder. (14504682)
2004
14
Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. (11910270)
2002
15
Seasonal affective disorder among general practice attenders. (11983634)
2002
16
Polysomnographic sleep effects of fluoxetine and nefazodone on a seasonal affective disorder patient. (14592151)
2002
17
Comparison of consultation rates in primary care attenders with and without seasonal affective disorder. (11223107)
2001
18
Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure. (11328240)
2001
19
Seasonal affective disorder: spatial organization of EEG power and coherence in the depressive state and in light-induced and summer remission. (11756015)
2001
20
Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission. (11682283)
2001
21
Melatonin, psoralens, and the genetic basis of seasonal affective disorder and seasonality. (10790773)
2000
22
Accelerated post-glucose glycaemia and altered alliesthesia-test in Seasonal Affective Disorder. (10363663)
1999
23
Winter and summer outdoor light exposure in women with and without seasonal affective disorder. (10701473)
1999
24
Winter depression with spring exacerbation: A frequent occurrence in women with seasonal affective disorder. (10575328)
1999
25
Bright morning light reduces depressive symptoms in seasonal affective disorder. (18751194)
1999
26
Seasonal affective disorder. (10389057)
1999
27
Phototherapy for the treatment of seasonal affective disorder. (10848168)
1999
28
Seasonal Affective Disorder and response to light in two patients with learning disability. (9543203)
1998
29
Cognitive characteristics of seasonal affective disorder: a preliminary investigation. (9716282)
1998
30
Prevention of winter seasonal affective disorder by bright-light treatment. (8878339)
1996
31
Seasonal affective disorder in a tropical country: a case report. (7792337)
1995
32
Light therapy for seasonal affective disorder. The effects of timing. (7620745)
1995
33
Phototherapy for seasonal affective disorder: a blind comparison of three different schedules. (8010369)
1994
34
Heat-loss response to a thermal challenge in seasonal affective disorder. (7972575)
1994
35
1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: effects of light. (7701056)
1994
36
A controlled trial of cyanocobalamin (vitamin B12) in the treatment of winter seasonal affective disorder. (7852661)
1994
37
Spontaneous eye blink rate in winter seasonal affective disorder. (8516420)
1993
38
Side effects of light therapy in seasonal affective disorder. (8465886)
1993
39
Defining seasonal affective disorder(s) (1391279)
1992
40
Recurrent brief depression and its relationship to seasonal affective disorder. (1390951)
1992
41
Clinical evidence for thyroid dysfunction in patients with seasonal affective disorder. (1438648)
1992
42
Seasonal panic disorder: a possible variant of seasonal affective disorder. (1305610)
1992
43
Seasonal affective disorder (SAD) with non-24-hour sleep-wake rhythm during depressive phase. (1635314)
1992
44
Shift-workers and seasonal affective disorder. (2025869)
1991
45
Seasonal affective disorder: a new light? (2037986)
1991
46
Phototherapy for seasonal affective disorder (SAD) in Siberia. (1365144)
1991
47
Seasonal affective disorder. A sad situation. (2235576)
1990
48
Effects of different wavelengths in seasonal affective disorder. (2149726)
1990
49
Seasonal affective disorder. Winter depression. (2235575)
1990
50
Seasonal affective disorder and visual impairment: two case studies. (2600066)
1989

Genetic Variations for Seasonal Affective Disorder

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Expression for genes affiliated with Seasonal Affective Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seasonal Affective Disorder

Search GEO for disease gene expression data for Seasonal Affective Disorder.

Pathways for genes affiliated with Seasonal Affective Disorder

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 49PharmGKB, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology
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Pathways related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9HTR2A, HTR2C
29.6CLOCK, NPAS2
39.6CLOCK, NPAS2
49.6NPAS2, CLOCK
59.6POMC, CRH
69.4SLC6A4, GABBR1, GNB3
79.4CRH, GABBR1, GAL
8
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9.3PER3, CLOCK, NPAS2
9
Hide members
9.3GNB3, HTR2C, HTR2A, OPN4
109.2TPH1, SLC6A4, HTR2A, HTR1A, GNB3
11
Hide members
9.1HTR2C, HTR1A, HTR2A, DRD4, SLC6A4
128.3GNB3, HTR1A, NPY, GABBR1, TPH1
13
Hide members
7.5GNB3, HTR2C, HTR1A, HTR2A, DRD4, GABBR1
14
Hide members
5.7POMC, GNB3, HTR2C, HTR1A, HTR2A, NPY
15
Hide members
5.7NPY, HTR2A, HTR1A, HTR2C, GNB3, DRD4

Compounds for genes affiliated with Seasonal Affective Disorder

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 280)
idCompoundScoreTop Affiliating Genes
1gnrh4410.0GAL, GABBR1
2antidepressants499.5GNB3, TPH1, HTR2A, HTR1A, GAL
3fluvoxamine44 49 1111.3HTR2A, TPH1, CLOCK, HTR1A, SLC6A4
4pindolol44 28 1111.2HTR1A, HTR2A, PRL, SLC6A4
5m-chlorophenylpiperazine449.2HTR2C, SLC6A4, PRL, HTR2A, HTR1A
6mcpp449.2SLC6A4, HTR2A, HTR1A, HTR2C, PRL
7terguride28 4410.2HTR2A, HTR2C, HTR1A, PRL, DRD4
8paroxetine44 49 28 1112.2HTR2A, HTR1A, TPH1, SLC6A4, PRL, DRD4
95-hydroxytryptophan449.2TPH1, SLC6A4, PRL, CRH, HTR2A, HTR1A
10lisuride28 44 1111.2PRL, HTR2C, HTR2A, HTR1A, DRD4
11paliperidone44 1110.2DRD4, HTR2C, HTR2A, PRL, HTR1A
12pergolide28 44 1111.1HTR2C, PRL, HTR2A, DRD4, HTR1A
13pramipexole44 49 28 1112.1HTR1A, HTR2A, DRD4, PRL, HTR2C
14flesinoxan449.1HTR2A, POMC, PRL, HTR1A
15roxindole28 4410.1DRD4, HTR2A, HTR1A, HTR2C
16cabergoline28 44 1111.0HTR1A, HTR2C, HTR2A, DRD4, PRL
17citalopram49 44 11 2412.0HTR2C, HTR2A, PRL, TPH1, HTR1A, SLC6A4
18aripiprazole28 49 44 11 2413.0PRL, HTR2C, DRD4, HTR2A, HTR1A
19clomipramine44 49 1111.0CRH, SLC6A4, HTR2A, HTR1A, HTR2C, PRL
20ziprasidone49 28 44 1112.0PRL, DRD4, HTR2A, HTR1A, HTR2C
21risperidone28 44 49 59 11 2414.0HTR1A, HTR2A, DRD4, PRL, SLC6A4, HTR2C
22olanzapine49 44 28 11 2412.9PRL, GNB3, DRD4, HTR2A, HTR2C, HTR1A
23apomorphine44 28 1110.9HTR1A, HTR2C, PRL, HTR2A, DRD4
24ipsapirone44 289.9HTR1A, HTR2A, PRL, POMC, HTR2C
25quetiapine44 49 28 11 2412.8DRD4, PRL, HTR2C, HTR1A, HTR2A
26mhpg448.7CRH, DRD4, NPY, SLC6A4, PRL
27maoa448.7TPH1, SLC6A4, HTR2C, HTR1A, HTR2A, DRD4
28bromocriptine28 44 1110.7DRD4, POMC, HTR1A, HTR2C, PRL, HTR2A
29yohimbine44 28 2 1111.6HTR2C, CRH, NPY, HTR2A, HTR1A
30sulpiride44 28 1110.6HTR2C, NPY, DRD4, PRL, CRH
31fluoxetine49 44 28 1111.5GNB3, HTR2C, HTR1A, HTR2A, SLC6A4, PRL
32melatonin44 59 28 11 2412.4HTR2C, CLOCK, GAL, TPH1, PRL, OPN4
33topiramate44 11 2410.4CRH, POMC, GAL, NPY, HTR2C
34mirtazapine49 44 1110.3GAL, CRH, PRL, POMC, SLC6A4, HTR2A
35clozapine44 28 49 1111.1SLC6A4, POMC, DRD4, HTR1A, HTR2A, PRL
36haloperidol44 28 2 49 1112.0NPY, DRD4, HTR2A, HTR1A, SLC6A4, POMC
37amphetamine44 118.9SLC6A4, POMC, GABBR1, NPY, GAL, TPH1
38catecholamine447.8POMC, TPH1, CRH, GABBR1, NPY, DRD4
39corticosterone44 59 249.8GAL, NPY, HTR1A, CRH, PRL, POMC
40opiate447.6GAL, NPY, GABBR1, PRL, CRH, POMC
41clonidine44 28 119.5GAL, GABBR1, POMC, PRL, NPY, SLC6A4
42epinephrine44 11 249.5GAL, SLC6A4, GNB3, POMC, PRL, NPY
43fenfluramine28 44 119.3HTR1A, HTR2C, HTR2A, NPY, TPH1, SLC6A4
44gaba447.2NPY, GABBR1, DRD4, GAL, HTR2C, CRH
45acetylcholine44 49 28 11 2411.2NPY, HTR2C, HTR1A, TPH1, POMC, CRH
46adenylate447.0HTR1A, GABBR1, OPN4, CRH, POMC, HTR2C
47cocaine44 118.0HTR2C, NPY, DRD4, GAL, GABBR1, CRH
485-hydroxytryptamine446.3TPH1, SLC6A4, POMC, PRL, CRH, GABBR1
49norepinephrine44 11 248.0DRD4, NPY, HTR2A, HTR1A, HTR2C, GNB3
50dopamine44 28 11 248.5TPH1, GNB3, HTR2C, HTR1A, HTR2A, NPY

GO Terms for genes affiliated with Seasonal Affective Disorder

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16Gene Ontology
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Cellular components related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.7POMC, PRL, GAL
2integral to plasma membraneGO:0058878.6SLC6A4, GABBR1, DRD4, HTR2A, HTR1A, HTR2C

Biological processes related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR2A, HTR1A
2regulation of serotonin secretionGO:01406210.2HTR1A, CRH
3response to immobilization stressGO:03590210.2CRH, TPH1
4regulation of dopamine metabolic processGO:04205310.2HTR1A, DRD4
5phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2C, HTR2A
6positive regulation of phosphatidylinositol biosynthetic processGO:01051310.1HTR2C, HTR2A
7regulation of behaviorGO:05079510.0HTR1A, HTR2A
8vasoconstrictionGO:04231010.0SLC6A4, HTR1A
9serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR1A, HTR2C
10synaptic transmission, dopaminergicGO:0019639.9DRD4, CRH
11behavioral fear responseGO:0016629.9DRD4, HTR1A, HTR2C
12parturitionGO:0075679.8PRL, CRH
13cellular calcium ion homeostasisGO:0068749.7DRD4, HTR2A, HTR2C
14regulation of appetiteGO:0320989.6POMC, HTR2C
15circadian rhythmGO:0076239.0TPH1, PER3, SLC6A4, CLOCK, PRL
16feeding behaviorGO:0076319.0HTR2C, NPY, GAL, CRH
17regulation of blood pressureGO:0082178.9POMC, NPY, GNB3
18response to drugGO:0424938.8HTR2C, HTR2A, GAL, CRH, PRL, SLC6A4
19neuropeptide signaling pathwayGO:0072188.4POMC, GAL, NPY
20synaptic transmissionGO:0072688.2GNB3, HTR2C, HTR2A, NPY, GABBR1, CRH

Molecular functions related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
11-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.9HTR2A, HTR2C
2serotonin receptor activityGO:0049939.7HTR2A, HTR1A, HTR2C
3drug bindingGO:0081449.6HTR2C, HTR2A, DRD4
4serotonin bindingGO:0513789.6HTR2C, HTR2A
5neuropeptide hormone activityGO:0051849.2CRH, GAL, NPY
6hormone activityGO:0051799.1POMC, PRL, CRH
7signal transducer activityGO:0048718.9PER3, CLOCK, NPAS2, GNB3

Products for genes affiliated with Seasonal Affective Disorder

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Sources for Seasonal Affective Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet