MCID: SSN001
MIFTS: 56

Seasonal Affective Disorder malady

Mental diseases category
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Summaries for Seasonal Affective Disorder

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MedlinePlus:33 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards based summary: Seasonal Affective Disorder, also known as winter depression, is related to personality disorder and bipolar disorder. An important gene associated with Seasonal Affective Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. The compounds antidepressants and flesinoxan have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and eye, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Disease Ontology:8 A mental depression that involves presentation of depressive symptoms only during a specific season of the year.

Wikipedia:65 Seasonal affective disorder (SAD), also known as winter depression, winter blues, summer depression,... more...

Description from OMIM:46 608516

Aliases & Classifications for Seasonal Affective Disorder

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Seasonal Affective Disorder, Aliases & Descriptions:

Name: Seasonal Affective Disorder 8 46 44 33 62
 
Winter Depression 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0060167

Related Diseases for Seasonal Affective Disorder

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Diseases related to Seasonal Affective Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.9TPH1, DRD4, SLC6A4
2bipolar disorder30.8HTR2A, SLC6A4
3attention deficit hyperactivity disorder30.7SLC6A4, HTR2A, DRD4
4chronic fatigue syndrome30.7SLC6A4, POMC, CRH, HTR1A
5melancholia30.7POMC, CRH
6bulimia nervosa30.7SLC6A4, NPY, HTR2A
7obsessive-compulsive disorder30.6TPH1, HTR1A, DRD4, SLC6A4, HTR2A
8delayed sleep phase syndrome30.4CLOCK, PER3
9panic disorder30.4HTR1A, CRH, POMC, SLC6A4
10eating disorder29.7GAL, HTR2A, HTR1A, CRH, SLC6A4, NPY
11obesity28.7DRD4, NPY, GNB3, POMC, HTR2A, CLOCK
12anorexia nervosa28.5HTR2C, HTR2A, SLC6A4, NPY, GAL, DRD4
13mood disorder28.0GNB3, POMC, SLC6A4, NPY, GABBR1, GAL
14pathological gambling10.6DRD4
15neuroleptic malignant syndrome10.6HTR1A
16alcoholic psychosis10.5SLC6A4
17oppositional defiant disorder10.5DRD4
18pervasive developmental disorder10.5SLC6A4
19antisocial personality disorder10.5HTR2A, SLC6A4
20premature ejaculation10.5HTR1A, SLC6A4
21serotonin syndrome10.5HTR1A, HTR2A
22generalized anxiety disorder10.4SLC6A4, HTR1A
23cerebritis10.4
24thyroiditis10.4
25endogenous depression10.4CRH, SLC6A4
26social phobia10.4HTR1A, SLC6A4
27adrenal carcinoma10.4POMC
28borderline personality disorder10.4SLC6A4, TPH1
29conduct disorder10.4DRD4, SLC6A4
30blindness10.4
31substance dependence10.4SLC6A4, DRD4, TPH1
32anxiety disorder10.4SLC6A4, CRH, TPH1
33irritable bowel syndrome10.4TPH1, SLC6A4, CRH
34autistic disorder10.4HTR1A, HTR2A, SLC6A4
35substance abuse10.4DRD4, SLC6A4, CRH
36cyclothymic disorder10.3HTR2A, HTR2C
37withdrawal disorder10.3GABBR1, CRH
38gonadal disease10.3CRH, POMC
39cushing's syndrome10.3CRH, POMC
40amnestic disorder10.3HTR1A, POMC
41gastrointestinal system disease10.3TPH1, CRH
42hypothalamic disease10.3CRH, PRL
43hypoadrenalism10.3CRH, POMC
44infantile epileptic encephalopathy10.3POMC, CRH
45drug addiction10.3GABBR1, CRH
46gilles de la tourette syndrome10.3DRD4, HTR1A, SLC6A4, HTR2A
47sudden infant death syndrome10.3HTR2A, HTR1A, TPH1, SLC6A4
48alcohol abuse10.3GAL, SLC6A4
49cocaine dependence10.3POMC, SLC6A4
50nicotine dependence10.3DRD4, SLC6A4

Graphical network of the top 20 diseases related to Seasonal Affective Disorder:



Diseases related to seasonal affective disorder

Symptoms for Seasonal Affective Disorder

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Clinical features from OMIM:

608516

Drugs & Therapeutics for Seasonal Affective Disorder

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Drug clinical trials:

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Genetic Tests for Seasonal Affective Disorder

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Anatomical Context for Seasonal Affective Disorder

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MalaCards organs/tissues related to Seasonal Affective Disorder:

32
Brain, Thyroid, Eye, Skin, Testes, Bone, Retina, Spinal cord, T cells, Pineal, Pituitary

Animal Models for Seasonal Affective Disorder or affiliated genes

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MGI Mouse Phenotypes related to Seasonal Affective Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4POMC, HTR2A, CRH, GAL, SLC6A4, PRL
2MP:00053757.4TPH1, POMC, CLOCK, GABBR1, NPY, HTR2C
3MP:00107716.9GAL, TPH1, CRH, PRL, CLOCK, POMC
4MP:00053786.3GABBR1, SLC6A4, NPY, GAL, CRH, TPH1
5MP:00053765.1TPH1, PRL, HTR1A, HTR2C, DRD4, CLOCK
6MP:00036314.6GNB3, PER3, POMC, CLOCK, PRL, HTR2C
7MP:00053864.5TPH1, POMC, CLOCK, PRL, HTR2A, HTR2C

Publications for Seasonal Affective Disorder

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Articles related to Seasonal Affective Disorder:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Altered resting-state activity in seasonal affective disorder. (22987670)
2014
2
Can transcranial brain-targeted bright light treatment via ear canals be effective in relieving symptoms in seasonal affective disorder? A pilot study. (22296809)
2012
3
A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. (18804284)
2009
4
Season of birth in siblings of patients with seasonal affective disorder. A test of the parental conception habits hypothesis. (17902009)
2007
5
Escitalopram in seasonal affective disorder: results of an open trial. (17327956)
2007
6
Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder. (17151164)
2006
7
What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)? (15645001)
2005
8
Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy. (12586452)
2003
9
Evidence supports validity of seasonal affective disorder. (12420659)
2002
10
Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. (11910270)
2002
11
Genetics of seasonal affective disorder. (11897319)
2002
12
Is dawn simulation effective in ameliorating the difficulty awakening in seasonal affective disorder associated with hypersomnia? (12103471)
2002
13
Seasonal affective disorder in an Arctic community. (11942945)
2002
14
Monoaminergic function in the pathogenesis of seasonal affective disorder. (11806867)
2001
15
Possible genetic link between seasonal affective disorder and eating disorders. (11291638)
2001
16
Seasonality, social zeitgebers and mood variability in entrainment of mood. Implications for seasonal affective disorder. (10814770)
2000
17
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
18
Accelerated post-glucose glycaemia and altered alliesthesia-test in Seasonal Affective Disorder. (10363663)
1999
19
Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A. (10089016)
1999
20
The prevalence of seasonal affective disorder in The Netherlands: a prospective and retrospective study of seasonal mood variation in the general population. (10386184)
1999
21
Winter and summer outdoor light exposure in women with and without seasonal affective disorder. (10701473)
1999
22
Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. (9577843)
1998
23
Case study: dawn simulation as maintenance treatment in a nine-year-old patient with seasonal affective disorder. (9735618)
1998
24
Suicide after bright light treatment in seasonal affective disorder: a case report. (9771819)
1998
25
Effects of fluoxetine versus bright light in the treatment of seasonal affective disorder. (9723147)
1998
26
Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms. (9107154)
1997
27
Eating style in seasonal affective disorder: who will gain weight in winter? (9056125)
1997
28
L-tryptophan augmentation of light therapy in patients with seasonal affective disorder. (9114947)
1997
29
Suicidal tendencies as a complication of light therapy for seasonal affective disorder: a report of three cases. (9378689)
1997
30
Seasonal affective disorder in Australia: is photoperiod critical? (9140637)
1997
31
School and seasonal affective disorder. (8633723)
1996
32
Seasonal affective disorder in a tropical country: a case report. (7792337)
1995
33
Multicenter, placebo-controlled study of fluoxetine in seasonal affective disorder. (8526243)
1995
34
A longitudinal follow-up study of seasonal affective disorder. (7755115)
1995
35
Influence of phototherapy treatment duration for seasonal affective disorder: outcome at one vs. two weeks. (8580228)
1995
36
Estrogen could control photoperiodic adjustment in seasonal affective disorder. (8524174)
1995
37
Olfactory function in winter seasonal affective disorder. (7573599)
1995
38
Seasonal affective disorder: are the DSM-III-R criteria valid? (7846253)
1994
39
Multiple chemical sensitivity: lessons from seasonal affective disorder. (7778119)
1994
40
Onset of depressive episodes in a woman with seasonal affective disorder of "spring type" coincident with atmospheric temperature, but not with sunshine duration. (8201789)
1993
41
Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder. (8127946)
1993
42
Predictors of response to phototherapy in seasonal affective disorder. (1544295)
1992
43
Defining seasonal affective disorder(s) (1391279)
1992
44
A seasonal depression. Management of seasonal affective disorder. (1465471)
1992
45
Uncommon disorders. Summer seasonal affective disorder. (1503943)
1992
46
Diurnal variation of symptoms in seasonal affective disorder. (1862158)
1991
47
Prolactin levels in women with seasonal affective disorder. (2343937)
1990
48
Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. (2497477)
1989
49
Ophthalmic implications of seasonal affective disorder. (2668388)
1989
50
Seasonal affective disorder. (2622845)
1989

Variations for Seasonal Affective Disorder

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Expression for genes affiliated with Seasonal Affective Disorder

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Expression patterns in normal tissues for genes affiliated with Seasonal Affective Disorder

Search GEO for disease gene expression data for Seasonal Affective Disorder.

Pathways for genes affiliated with Seasonal Affective Disorder

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Pathways related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8POMC, CRH
29.7HTR2C, HTR2A
3
Show member pathways
9.6GNB3, GABBR1, SLC6A4
49.5NPAS2, CLOCK
59.5NPAS2, CLOCK
69.5GABBR1, GAL, CRH
79.5GNB3, POMC, CRH
89.5CRH, POMC, GNB3
9
Show member pathways
9.4HTR2C, HTR2A, GNB3
10
Show member pathways
9.3DRD4, HTR1A, HTR2C, HTR2A
119.2GNB3, TPH1, HTR2A, HTR1A, SLC6A4
12
Show member pathways
9.2GNB3, HTR2A, HTR2C, HTR1A
13
Show member pathways
9.2GNB3, HTR2A, HTR2C, OPN4
14
Show member pathways
9.1NPAS2, CLOCK, PER3
159.0TPH1, HTR2A, HTR2C, HTR1A, SLC6A4
168.5GNB3, TPH1, HTR1A, GABBR1, NPY
17
Show member pathways
7.9GNB3, CLOCK, PRL, CRH, NPY
18
Show member pathways
7.1GABBR1, DRD4, HTR1A, HTR2C, HTR2A, CLOCK
19
Show member pathways
5.9HTR2C, HTR2A, PRL, POMC, GNB3, HTR1A
20
Show member pathways
5.9NPY, GNB3, POMC, OPN4, GABBR1, GAL

Compounds for genes affiliated with Seasonal Affective Disorder

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Compounds related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 294)
idCompoundScoreTop Affiliating Genes
1antidepressants509.4TPH1, HTR2A, GAL, GNB3, HTR1A
2flesinoxan449.2PRL, HTR2A, HTR1A, POMC
35-hydroxytryptophan449.2PRL, HTR1A, CRH, SLC6A4, TPH1, HTR2A
4paroxetine44 50 28 1112.2PRL, TPH1, HTR2A, DRD4, SLC6A4, HTR1A
5m-chlorophenylpiperazine449.1HTR2A, HTR2C, HTR1A, SLC6A4, PRL
6mcpp449.1SLC6A4, PRL, HTR2A, HTR1A, HTR2C
7fluvoxamine44 50 1111.1TPH1, CLOCK, HTR2A, HTR1A, SLC6A4
8terguride44 2810.1HTR1A, PRL, HTR2A, DRD4, HTR2C
9selective serotonin reuptake inhibitors509.1SLC6A4, GAL, HTR2A, HTR1A
10lisuride44 28 1111.0DRD4, HTR1A, HTR2C, PRL, HTR2A
11paliperidone44 1110.0PRL, HTR2A, DRD4, HTR2C, HTR1A
12pergolide44 28 1111.0PRL, HTR2A, HTR2C, HTR1A, DRD4
13pramipexole44 28 50 1112.0PRL, HTR2A, HTR2C, HTR1A, DRD4
14ipsapirone44 289.9POMC, PRL, HTR2A, HTR2C, HTR1A
15cabergoline44 28 1110.9PRL, HTR2A, HTR2C, HTR1A, DRD4
16clomipramine44 50 1110.9CRH, SLC6A4, HTR1A, HTR2C, HTR2A, PRL
17quetiapine44 50 28 24 1112.9PRL, DRD4, HTR2A, HTR1A, SLC6A4, HTR2C
18aripiprazole28 44 50 24 1112.9HTR1A, PRL, DRD4, HTR2C, HTR2A
19risperidone44 50 28 61 24 1113.8PRL, SLC6A4, DRD4, HTR1A, HTR2C, HTR2A
20ziprasidone28 50 44 1111.8HTR1A, HTR2C, DRD4, PRL, HTR2A
21maoa448.8SLC6A4, TPH1, POMC, HTR2A, HTR2C, HTR1A
22mhpg448.7NPY, PRL, CRH, SLC6A4, DRD4
23citalopram44 50 24 1111.7SLC6A4, HTR1A, HTR2C, CRH, HTR2A, PRL
24apomorphine28 44 1110.6HTR2C, PRL, HTR1A, DRD4, HTR2A
25olanzapine44 50 28 24 1112.6HTR2C, HTR1A, HTR2A, DRD4, GNB3, PRL
26sulpiride44 28 1110.4DRD4, NPY, CRH, HTR2C, PRL
27yohimbine44 2 28 1111.4HTR1A, NPY, CRH, HTR2C, HTR2A
28fluoxetine44 50 28 1111.4SLC6A4, CRH, HTR1A, HTR2C, GNB3, TPH1
29bromocriptine44 28 1110.4POMC, PRL, HTR2A, HTR2C, HTR1A, DRD4
30topiramate44 50 24 1111.3HTR2C, CRH, GAL, NPY, POMC
31mirtazapine44 50 1110.3SLC6A4, GAL, CRH, HTR2C, HTR2A, PRL
32amphetamine44 50 1110.2NPY, TPH1, POMC, DRD4, GAL, GABBR1
33clozapine44 28 50 1111.2DRD4, HTR1A, HTR2C, HTR2A, PRL, POMC
34catecholamine448.1NPY, GABBR1, GAL, DRD4, CRH, POMC
35haloperidol44 50 28 2 1112.1PRL, DRD4, HTR2A, HTR1A, POMC, NPY
36melatonin44 28 61 24 1112.1GAL, PRL, CLOCK, TPH1, OPN4, DRD4
37corticosterone44 61 249.9PRL, HTR1A, CRH, GAL, NPY, POMC
38opiate447.8CRH, POMC, SLC6A4, PRL, NPY, GABBR1
39clonidine44 50 28 1110.8POMC, GAL, GABBR1, NPY, SLC6A4, PRL
40epinephrine44 24 119.6PRL, CRH, POMC, DRD4, GAL, SLC6A4
41acetylcholine44 50 28 24 1111.5GAL, TPH1, POMC, HTR1A, HTR2C, CRH
42gaba447.4TPH1, POMC, HTR2C, SLC6A4, DRD4, CRH
43fenfluramine44 28 119.4POMC, NPY, SLC6A4, CRH, PRL, HTR2A
44gnrh447.3GAL, POMC, PRL, HTR2C, CRH, GABBR1
45adenylate447.2GABBR1, CRH, NPY, HTR1A, HTR2C, POMC
46glutamate447.2SLC6A4, NPY, OPN4, GABBR1, GAL, DRD4
47cocaine44 118.1CRH, DRD4, GAL, GABBR1, NPY, POMC
485-hydroxytryptamine446.4SLC6A4, NPY, GABBR1, GAL, DRD4, CRH
49norepinephrine44 24 118.2POMC, TPH1, GNB3, HTR2C, SLC6A4, NPY
50dopamine44 28 24 118.5HTR2A, PRL, CLOCK, POMC, TPH1, GNB3

GO Terms for genes affiliated with Seasonal Affective Disorder

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Cellular components related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.7SLC6A4, TPH1, GNB3
2integral component of plasma membraneGO:0058878.7SLC6A4, GABBR1, DRD4, HTR1A, HTR2C, HTR2A
3plasma membraneGO:0058867.8GNB3, HTR2A, HTR2C, HTR1A, DRD4, GABBR1
4extracellular regionGO:0055767.6POMC, PRL, CRH, GAL, GABBR1, NPY

Biological processes related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR1A, HTR2A
2regulation of serotonin secretionGO:01406210.3CRH, HTR1A
3response to immobilization stressGO:03590210.2TPH1, CRH
4regulation of dopamine metabolic processGO:04205310.2DRD4, HTR1A
5synaptic transmission, dopaminergicGO:00196310.1DRD4, CRH
6regulation of behaviorGO:05079510.1HTR1A, HTR2A
7behavioral response to cocaineGO:04814810.1DRD4, HTR2A
8phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.1HTR2C, HTR2A
9positive regulation of phosphatidylinositol biosynthetic processGO:01051310.0HTR2A, HTR2C
10vasoconstrictionGO:04231010.0HTR1A, SLC6A4
11photoperiodismGO:0096489.9CLOCK, DRD4
12serotonin receptor signaling pathwayGO:0072109.8HTR2A, HTR2C, HTR1A
13behavioral fear responseGO:0016629.8HTR2C, HTR1A, DRD4
14cellular calcium ion homeostasisGO:0068749.7DRD4, HTR2C, HTR2A
15release of sequestered calcium ion into cytosolGO:0512099.7HTR2C, HTR2A
16regulation of appetiteGO:0320989.7POMC, HTR2C
17negative regulation of adenylate cyclase activityGO:0071949.6GABBR1, DRD4
18circadian rhythmGO:0076239.5TPH1, CLOCK, DRD4, SLC6A4
19circadian regulation of gene expressionGO:0329229.3CLOCK, PER3
20response to drugGO:0424939.2SLC6A4, GAL, CRH, HTR2C, HTR2A
21regulation of blood pressureGO:0082179.2NPY, POMC, GNB3
22neuropeptide signaling pathwayGO:0072189.0POMC, GAL, NPY
23feeding behaviorGO:0076318.9NPY, GAL, CRH, HTR2C
24synaptic transmissionGO:0072688.4NPY, GABBR1, CRH, HTR2C, HTR2A, GNB3

Molecular functions related to Seasonal Affective Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
11-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.9HTR2C, HTR2A
2serotonin bindingGO:0513789.7HTR2A, HTR2C
3serotonin receptor activityGO:0049939.7HTR1A, HTR2C, HTR2A
4drug bindingGO:0081449.6DRD4, HTR2C, HTR2A
5G-protein coupled receptor bindingGO:0016649.2NPY, POMC
6neuropeptide hormone activityGO:0051849.2CRH, GAL, NPY
7hormone activityGO:0051799.1CRH, PRL, POMC
8signal transducer activityGO:0048718.9PER3, GNB3, CLOCK, NPAS2
9protein bindingGO:0055156.6PER3, GNB3, CLOCK, PRL, HTR1A, CRH

Products for genes affiliated with Seasonal Affective Disorder

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Sources for Seasonal Affective Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet