MCID: SBC009
MIFTS: 39

Sebaceous Adenoma malady

Cancer diseases, Skin diseases, Endocrine diseases categories
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Summaries for Sebaceous Adenoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Sebaceous adenoma is a cutaneous condition characterized by a slow-growing tumour usually presenting as... more...

MalaCards: Sebaceous Adenoma, also known as skin appendage sebaceous adenoma, is related to glioblastoma multiforme and colorectal cancer. An important gene associated with Sebaceous Adenoma is MKI67 (marker of proliferation Ki-67), and among its related pathways are Cell Cycle / Checkpoint Control and Colorectal Cancer Metastasis. The compounds octreotide and biotin have been mentioned in the context of this disorder. Affiliated tissues include skin and salivary gland, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Sebaceous Adenoma

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Endocrine diseases


Aliases & Descriptions:

sebaceous adenoma 8 10 62
skin appendage sebaceous adenoma 8
adenoma of the sebaceous gland 8


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Disease Ontology8 DOID:2648
SNOMED-CT58 78424008
NCIt40 C4174

Related Diseases for Sebaceous Adenoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sebaceous Adenoma:



Diseases related to sebaceous adenoma

Symptoms for Sebaceous Adenoma

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Drugs & Therapeutics for Sebaceous Adenoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Sebaceous Adenoma

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Anatomical Context for Sebaceous Adenoma

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33MalaCards
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MalaCards organs/tissues related to Sebaceous Adenoma:

33
Skin, Salivary gland

Animal Models for Sebaceous Adenoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sebaceous Adenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5EGF, MSH2, ESR1

Publications for Sebaceous Adenoma

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52PubMed
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Articles related to Sebaceous Adenoma:

(show all 45)
idTitleAuthorsYear
1
A case of sebaceous adenoma of the eyelid showing excessively rapid growth. (23579539)
2013
2
Sebaceous adenoma arising within an ovarian mature cystic teratoma in Muir-Torre syndrome. (21684182)
2012
3
Metachronous occurrence of colorectal cancer in a muir-torre syndrome patient presenting with recurrent sebaceous adenoma of the eyelid: case report and updated review of the literature. (23149194)
2012
4
A rare case of sebaceous adenoma of the palate, with literature review. (21443818)
2011
5
Treatment of sebaceous adenoma with topical photodynamic therapy. (20956668)
2010
6
Sebaceous adenoma of the submandibular gland: a case report. (20032620)
2009
7
Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. (19652586)
2009
8
Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. (19167837)
2009
9
Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. (19101492)
2009
10
Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. (19697727)
2009
11
Sebaceous adenoma of the parotid gland in a 2-year-old male. (17418275)
2007
12
Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia. (17893552)
2007
13
Penile sebaceous adenoma. (17637371)
2007
14
Sebaceous adenoma of the parotid gland. (16878064)
2006
15
Sebaceous adenoma of the eyelid in Muir-Torre syndrome. (15824235)
2005
16
Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. (14505629)
2003
17
Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules. (14629335)
2003
18
Sebaceous adenoma of the cheek. (11755830)
2002
19
Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. (12354803)
2002
20
Sebaceous adenoma in the submandibular gland. (11870356)
2002
21
Sebaceous adenomas with atypical immunohistochemical features in the Muir-Torre syndrome [leter]. (10233335)
1999
22
Solitary facial lesion. Sebaceous adenoma in association with Muir-Torre syndrome (MTS). (9006382)
1997
23
Immunohistochemical study on sebaceous adenoma and sebaceous carcinoma arising in parotid gland. (21594425)
1996
24
Sebaceous adenoma of the submandibular gland: a case report. (8863311)
1996
25
Sebaceous adenoma in the region of the medial canthus causing proptosis. (10707724)
1995
26
Sebaceous adenoma with a cutaneous horn. (7560356)
1995
27
Sebaceous adenoma of parotid gland--a rare tumour diagnosed by fine needle aspiration cytology. (7880973)
1994
28
CT of sebaceous adenoma of the parotid gland. (7976936)
1994
29
Sebaceous adenoma in a patient with acquired immunodeficiency syndrome. (3355190)
1988
30
Sebaceous adenoma of the oral mucosa. (3469349)
1987
31
Sebaceous adenoma of the oral cavity. (6571741)
1983
32
Pathology quiz case 1: Sebaceous adenoma. (6849571)
1983
33
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. II. A freeze-fracture study in conjunction with filipin. (6277960)
1982
34
Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. (7338533)
1981
35
Sebaceous adenoma of the eyelid and visceral malignancy. (4440729)
1974
36
A SEBACEOUS ADENOMA. HISTOLOGICAL AND CHEMICAL STUDIES. (14183145)
1964
37
Sebaceous adenoma of the submaxillary salivary gland. Report of a case. (14011757)
1963
38
A REVIEW ON SEBACEOUS ADENOMA WITH REPORT OF A CASE IN THE EXTERNAL AUDITORY MEATUS. (14082064)
1963
39
Sebaceous adenoma in a dog. (13407925)
1957
40
Scalp: sebaceous adenoma. (13094140)
1953
41
Diethylstilbestrol in the treatment of senile sebaceous adenoma. (14952023)
1952
42
Sebaceous adenoma; review of the literature and report of a case. (18919779)
1948
43
Senile Sebaceous Adenoma. (19991727)
1938
44
Pringle Type of Sebaceous Adenoma. (19990196)
1935
45
Sebaceous Adenoma (Pringle Type) in Mother and Daughter. (19979593)
1917

Variations for Sebaceous Adenoma

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Expression for genes affiliated with Sebaceous Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sebaceous Adenoma

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Pathways for genes affiliated with Sebaceous Adenoma

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Sources:
50PathCards, 5Cell Signaling Technology, 53QIAGEN, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Sebaceous Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MSH2, MKI67
29.3EGF, MSH2
3
Show member pathways
Signal transduction PTEN pathway60
9.3EGF, MSH2
4
Show member pathways
9.1MSH2, ESR1
59.1ESR1, MSH2
6
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.0EGF, ESR1
7
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0EGF, ESR1
89.0EGF, ESR1
99.0EGF, ESR1

Compounds for genes affiliated with Sebaceous Adenoma

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Sebaceous Adenoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1octreotide45 61 29 1112.7MKI67, EGF
2biotin45 24 1111.7MSH2, MKI67
3thymidylate459.7MSH2, MKI67
4irinotecan45 51 1111.7EGF, MKI67
5anastrozole45 51 1111.6MKI67, ESR1
6letrozole45 51 61 1112.6ESR1, MKI67
717beta-hydroxysteroid459.6ESR1, MKI67
8progestins459.6ESR1, MKI67
9bromodeoxyuridine459.5EGF, MKI67
10hydroxyflutamide45 2910.4EGF, ESR1
11lapatinib45 51 1111.4EGF, ESR1
12bicalutamide45 61 1111.4ESR1, EGF
13trastuzumab45 51 1111.4EGF, ESR1
144-hydroxytamoxifen459.3ESR1, EGF
15gefitinib45 51 1111.3ESR1, EGF
16progestin459.3EGF, ESR1
17tgf beta1459.3EGF, MKI67
18geldanamycin45 51 61 1112.3EGF, ESR1
19methotrexate51 45 1111.2ESR1, MKI67
20mg 13245 6110.1ESR1, EGF
21dihydrotestosterone45 29 24 1112.1ESR1, EGF
22paraffin459.0MSH2, ESR1, MKI67
23fulvestrant45 51 29 1112.0EGF, ESR1, MKI67
24mifepristone45 29 61 1112.0EGF, ESR1, MKI67
25gnrh459.0MKI67, ESR1, EGF
26tamoxifen45 51 29 1112.0EGF, ESR1, MKI67
27paclitaxel45 51 1111.0MKI67, ESR1, EGF
28estradiol45 24 1111.0MKI67, ESR1, EGF
29cycloheximide458.9MKI67, ESR1, EGF
30progesterone45 29 61 24 1112.9EGF, ESR1, MKI67
31cyclophosphamide45 51 1110.9ESR1, MKI67
32testosterone45 61 24 1111.9EGF, ESR1, MKI67
33steroid458.9EGF, ESR1, MKI67
34vegf458.8MKI67, ESR1, EGF
35estrogen458.8MKI67, ESR1, EGF
36retinoic acid45 249.6MKI67, ESR1, EGF
375fluorouracil458.5MKI67, ESR1, MSH2, EGF
38doxorubicin45 51 1110.5EGF, MSH2, ESR1, MKI67
39cisplatin45 51 61 1111.5MKI67, ESR1, MSH2, EGF

GO Terms for genes affiliated with Sebaceous Adenoma

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16Gene Ontology
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Biological processes related to Sebaceous Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male gonad developmentGO:0085849.1MSH2, ESR1
2mammary gland alveolus developmentGO:0607498.7EGF, ESR1

Molecular functions related to Sebaceous Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.5MSH2, MKI67
2protein bindingGO:0055157.2EGF, PLIN3, MSH2, ESR1, MKI67

Products for genes affiliated with Sebaceous Adenoma

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Sources for Sebaceous Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet