Sebastian Syndrome malady

MalaCards: Sebastian Syndrome, also known as sebastian platelet syndrome, is related to may-hegglin anomaly and epstein syndrome. An important gene associated with Sebastian Syndrome is MYH9 (myosin, heavy chain 9, non-muscle).

OMIM: 605249

sebastian syndrome 7 16 33 32 43 sebastian platelet syndrome 16

Diseases related to sebastian syndrome by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	may-hegglin anomaly	8.1
2	epstein syndrome	6.3
3	fechtner syndrome	6.3
4	macrothrombocytopenia	6.3
5	myh9 related thrombocytopenia	6.3

Clinical features from OMIM: 605249

Approved drugs:

Drug clinical trials:

Articles related to sebastian syndrome:

id	Title	Authors	Year	Affiliating Genes
1	MYH9-related disease: may-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness. (12792306)	Seri M.... Savoia A.	2003	MYH9
2	Defective expression of GPIb/IX/V complex in platelets from patients with May-Hegglin anomaly and Sebastian syndrome. (12217806)	Di Pumpo M.... Balduini C.L.	2002	MYH9
3	Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome). (11159552)	Kunishima S.... Saito H.	2001	MYH9
4	Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. (10973259)	Seri M.... Martignetti J.A.	2000	MYH9

Genes related to sebastian syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	MYH9	myosin, heavy chain 9, non-muscle	11.1	Publications, Disorders, Summaries