MCID: SBR004
MIFTS: 40

Seborrheic Dermatitis

Categories: Skin diseases

Aliases & Classifications for Seborrheic Dermatitis

MalaCards integrated aliases for Seborrheic Dermatitis:

Name: Seborrheic Dermatitis 12 36 28 51 14 69
Seborrhoeic Dermatitis 12
Dermatitis, Seborrheic 41
Seborrhoeic Eczema 12
Skin Seborrheic 12
Seborrhea 12

Classifications:



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Disease Ontology 12 DOID:8741
ICD10 32 L21 L21.9
ICD9CM 34 690.1 690.10 706.3
MeSH 41 D012628
NCIt 46 C111888
KEGG 36 H01652
UMLS 69 C0036508

Summaries for Seborrheic Dermatitis

Disease Ontology : 12 A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss.

MalaCards based summary : Seborrheic Dermatitis, also known as seborrhoeic dermatitis, is related to seborrhea-like dermatitis with psoriasiform elements and seborrheic infantile dermatitis. An important gene associated with Seborrheic Dermatitis is BTD (Biotinidase). The drugs Salicylic acid and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Seborrhoeic dermatitis, also known as seborrhea, is a long-term skin disorder. Symptoms include red,... more...

Related Diseases for Seborrheic Dermatitis

Graphical network of the top 20 diseases related to Seborrheic Dermatitis:



Diseases related to Seborrheic Dermatitis

Symptoms & Phenotypes for Seborrheic Dermatitis

GenomeRNAi Phenotypes related to Seborrheic Dermatitis according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.4 IDH2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.4 SHBG
3 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.4 IDH2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 IDH2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.4 IDH2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.4 SHBG
7 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.4 IDH2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.4 SHBG
9 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.4 SHBG
10 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.4 IDH2 SHBG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.4 IDH2

Drugs & Therapeutics for Seborrheic Dermatitis

Drugs for Seborrheic Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
3
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
4
Ciclopirox Approved, Investigational Phase 4,Phase 3 29342-05-0 2749
5
Tacrolimus Approved, Investigational Phase 4,Phase 3 104987-11-3 445643 439492
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ketoconazole Approved, Investigational Phase 4,Phase 3 65277-42-1 3823 47576
8
Drospirenone Approved Phase 4 67392-87-4 68873
9
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11 Analgesics Phase 4,Phase 2,Phase 1
12 Salicylates Phase 4
13 Cyclooxygenase Inhibitors Phase 4
14 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
15 Hormone Antagonists Phase 4,Phase 3
16 Dermatologic Agents Phase 4,Phase 2,Phase 1
17 Hormones Phase 4,Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Emollients Phase 4
21 Anti-Infective Agents Phase 4,Phase 3
22 Antifungal Agents Phase 4,Phase 3
23 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
25 Keratolytic Agents Phase 4
26 Antirheumatic Agents Phase 4,Phase 2,Phase 1
27 insulin Phase 4
28 Estradiol valerate Phase 4 979-32-8
29 diuretics Phase 4
30 Micronutrients Phase 4
31 Mineralocorticoid Receptor Antagonists Phase 4
32 Mineralocorticoids Phase 4
33 Steroid Synthesis Inhibitors Phase 4,Phase 3
34 Natriuretic Agents Phase 4
35 Trace Elements Phase 4
36 Contraceptive Agents Phase 4,Phase 1,Phase 2
37 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
38 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
39 Vitamin B Complex Phase 4
40 Diuretics, Potassium Sparing Phase 4
41 Vitamins Phase 4
42 Drospirenone and ethinyl estradiol combination Phase 4
43 Estradiol 17 beta-cypionate Phase 4
44 Estradiol 3-benzoate Phase 4
45 Estrogens Phase 4
46 Polyestradiol phosphate Phase 4
47 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
48 Insulin, Globin Zinc Phase 4
49 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
50 Folate Nutraceutical Phase 4

Interventional clinical trials:

(show all 34)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
2 Promiseb Topical Cream for Cradle Cap Completed NCT01214434 Phase 4
3 Proactive Treatment of Tacrolimus Ointment for Adult Facial Seborrheic Dermatitis Completed NCT01591070 Phase 4 Tacrolimus;Tacrolimus
4 STUDY TO ASSESS THE LONG-TERM SAFETY OF EXTINA (KETOCONAZOLE) FOAM, 2% Completed NCT00703846 Phase 4 Ketoconazole
5 Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis Completed NCT00824863 Phase 4 ketoconazole 2% foam
6 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo
7 Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis Unknown status NCT01011621 Phase 3 0.5% prednisolone acetate cream;0.1% betamethasone valerate cream
8 Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis Completed NCT00862654 Phase 3 clobetasol propionate shampoo (4/week) - ketoconazole shampoo (2/week);clobetasol propionate shampoo (2/week) - ketoconazole shampoo (2/week);clobetasol propionate shampoo (2/week);ketoconazole shampoo (2/week)
9 Efficacy and Safety of ASF1057 in the Treatment of Seborrhoeic Dermatitis Completed NCT00565279 Phase 3 ASF1057;ASF1057
10 Two Topical K40 Formulations in Adults With Seborrhoeic Dermatitis (SD) of the Scalp Completed NCT01137630 Phase 2, Phase 3 K40a;K40b;Placebo
11 K301 for the Treatment of Seborrhoeic Eczema (SE) of the Scalp Completed NCT01137331 Phase 3 K301;Placebo
12 Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis Recruiting NCT02004860 Phase 3 Protopic (R);Mycoster (R)
13 A 4 Week Study of Elidel for the Treatment of Seborrheic Dermatitis Completed NCT00403559 Phase 2 Elidel
14 A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis of the Face Completed NCT00408330 Phase 2 Azelaic Acid 15% Gel;Inactive 15% gel base
15 A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Seborrheic Dermatitis Completed NCT02749383 Phase 2 PAC-14028 cream 0.3%;PAC-14028 cream 1.0%;PAC-14028 cream vehicle
16 Safety and Efficacy Study in Subjects With Seborrheic Dermatitis Completed NCT01703793 Phase 2 Test Product 49778;Test Product 10156;Vehicle (placebo)
17 Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers Completed NCT01254162 Phase 2 MTC896 Gel
18 The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage Completed NCT00991198 Phase 2 Topical oxygen;Topical oxygen;placebo
19 Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne Recruiting NCT03076320 Phase 1, Phase 2
20 Botulinum Toxin for Treatment of Seborrhic Dermatitis in Parkinsonian Patients Unknown status NCT00767546 Phase 1 Botulinum toxin
21 Petrolatum's Effect on Initial Symptoms of Nonscalp Seborrheic Dermatitis and Preventing Exacerbation Unknown status NCT01315951
22 Evaluation of the Effectiveness of a Product Containing Topical Hydrocortisone in the Treatment of Seborrheic Dermatitis of the Face Unknown status NCT01024374
23 HIV Indicator Diseases Across Europe Study Unknown status NCT01681706
24 HIV Indicator Diseases Survey Across Europe - UK Arm Unknown status NCT01196468
25 Neurobiology of the Scalp in Seborrheic Dermatitis Completed NCT02349854
26 HairMax LaserComb Open Label Study to Treat Seborrheic Dermatitis Completed NCT00830908
27 Safety and Efficacy of SEBORRHEAMEDIS Face Cream in Patients With Seborrheic Dermatitis Completed NCT02656368
28 Seborrheic Dermatitis: Ketoconazole 2% Foam Versus Ketoconazole 2% Shampoo Completed NCT01203189 ketoconazole 2% foam;ketoconazole 2% shampoo
29 An Investigator-Initiated Study to Assess the Cooling Effect of Triamcinolone Acetonide Aerosol When Used for Steroid-Responsive Dermatoses Completed NCT01736670 Triamcinolone Acetonide spray;Triamcinolone acetonide cream;Alcohol spray
30 Furocyst - Poly Cystic Ovary Syndrome Study Completed NCT02703064
31 Drug Utilization Study on Diane-35 (and Generics) in Three European Healthcare Databases Completed NCT02349399 Cyproterone / Ethinylestradiol (Diane-35, BAY86-5264) and its Generics
32 Drug Utilization Study on the Prescribing Indications for Cyproterone Acetate and Ethinyl Estradiol in 5 European Countries Recruiting NCT02494297
33 Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis Active, not recruiting NCT03114111 aminolevulinic acid (ALA);Placebo
34 Polymorphism of Extrapituitary Promoter of PRL Gene and Relationships With Serum Prolactin Levels in Acne Vulgaris. Not yet recruiting NCT03186222

Search NIH Clinical Center for Seborrheic Dermatitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dermatitis, seborrheic

Genetic Tests for Seborrheic Dermatitis

Genetic tests related to Seborrheic Dermatitis:

# Genetic test Affiliating Genes
1 Seborrheic Dermatitis 28

Anatomical Context for Seborrheic Dermatitis

MalaCards organs/tissues related to Seborrheic Dermatitis:

38
Skin, Testes, Ovary, Tongue, T Cells, Colon

Publications for Seborrheic Dermatitis

Articles related to Seborrheic Dermatitis:

(show top 50) (show all 78)
# Title Authors Year
1
Scalp Seborrheic Dermatitis and Dandruff Therapy Using a Herbal and Zinc Pyrithione-based Therapy of Shampoo and Scalp Lotion. ( 29410727 )
2018
2
New perspectives on dandruff and seborrheic dermatitis: lessons we learned from bacterial and fungal skin microbiota. ( 28690211 )
2017
3
Topical Medications for Seborrheic Dermatitis. ( 28290646 )
2017
4
Dasatinib-induced Seborrheic Dermatitis-like Eruption. ( 29104720 )
2017
5
The genetics of seborrheic dermatitis: a candidate gene approach and pilot genome-wide association study. ( 29203360 )
2017
6
A novel cosmetic antifungal/anti-inflammatory topical gel for the treatment of mild to moderate seborrheic dermatitis of the face: an open-label trial utilizing clinical evaluation and erythema-directed digital photography. ( 28121079 )
2017
7
History of Seborrheic Dermatitis: Conceptual and Clinico-Pathologic Evolution. ( 28705278 )
2017
8
Intertriginous and Seborrheic Dermatitis-Like Lesions in an Endocrine Patient. ( 29210714 )
2017
9
Prevalence and determinants of seborrheic dermatitis in a middle aged and elderly population: the Rotterdam Study. ( 28856679 )
2017
10
High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis. ( 28685715 )
2017
11
Treatment of Seborrheic Dermatitis Using a Novel Herbal-based Cream. ( 28458770 )
2017
12
Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial. ( 27778328 )
2017
13
Comparison of different regimens of pimecrolimus 1% cream in the treatment of facial seborrheic dermatitis. ( 28589618 )
2017
14
RF-Itraconazole Pulse Therapy for Seborrheic Dermatitis: A Treatment Approach to Consider. ( 28262107 )
2017
15
Hydrocortisone 1% cream and sertaconazole 2% cream to treat facial seborrheic dermatitis: A double-blind, randomized clinical trial. ( 28560305 )
2017
16
Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial. ( 27648378 )
2016
17
Noncorticosteroid Combination Shampoo versus 1% Ketoconazole Shampoo for the Management of Mild-to-Moderate Seborrheic Dermatitis of the Scalp: Results from a Randomized, Investigator-Single-Blind Trial Using Clinical and Trichoscopic Evaluation. ( 27171495 )
2016
18
Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. ( 27904273 )
2016
19
Seborrheic dermatitis treatment with stellate ganglion block: a case report. ( 27064785 )
2016
20
Malassezia arunalokei sp. nov., a Novel Yeast Species Isolated from Seborrheic Dermatitis Patients and Healthy Individuals from India. ( 27147721 )
2016
21
Clinical manifestation and associated factors of seborrheic dermatitis in Korea. ( 26771150 )
2016
22
Comprehensive pyrosequencing analysis of the bacterial microbiota of the skin of patients with seborrheic dermatitis. ( 27301664 )
2016
23
Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. ( 28905039 )
2016
24
Prevalence and related factors of psoriasis and seborrheic dermatitis: a community-based study. ( 27511489 )
2016
25
Biofilm production and antifungal susceptibility of co-cultured Malassezia pachydermatis and Candida parapsilosis isolated from canine seborrheic dermatitis. ( 26868903 )
2016
26
Isolation and identification of Malassezia species from Chinese and Korean patients with seborrheic dermatitis and in vitro studies on their bioactivity on sebaceous lipids and IL-8 production. ( 26786542 )
2016
27
Diffuse HIV-associated seborrheic dermatitis - a case series. ( 27013615 )
2016
28
Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. ( 27804089 )
2016
29
Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp. ( 27489423 )
2016
30
Loss of MPZL3 Function Causes Seborrheic Dermatitis-like Phenotype in Mice. ( 27488654 )
2016
31
Maintenance Therapy of Facial Seborrheic Dermatitis with 0.1% Tacrolimus Ointment. ( 26512166 )
2015
32
Evaluation of a Topical Anti-inflammatory/Antifungal Combination Cream in Mild-to-moderate Facial Seborrheic Dermatitis: An Intra-subject Controlled Trial Examining Treated vs. Untreated Skin Utilizing Clinical Features and Erythema-directed Digital Photography. ( 26430489 )
2015
33
Infantile seborrheic dermatitis: a pediatric Siddha medicine treatise. ( 25889138 )
2015
34
Seborrheic Dermatitis and Dandruff: A Comprehensive Review. ( 27148560 )
2015
35
Dermoscopic findings in scalp psoriasis and seborrheic dermatitis; two new signs; signet ring vessel and hidden hair. ( 25657395 )
2015
36
Diagnosis and treatment of seborrheic dermatitis. ( 25822272 )
2015
37
Plica polonica secondary to seborrheic dermatitis. ( 26456757 )
2015
38
Clinical Characteristics and Quality of Life of Seborrheic Dermatitis Patients in a Tropical Country. ( 26538714 )
2015
39
Malassezia intra-specific diversity and potentially new species in the skin microbiota from Brazilian healthy subjects and seborrheic dermatitis patients. ( 25695430 )
2015
40
Topical anti-inflammatory agents for seborrheic dermatitis of the face or scalp: summary of a Cochrane Review. ( 25629391 )
2015
41
Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial. ( 26016699 )
2015
42
Reflectance confocal microscopy features of seborrheic dermatitis for plaque psoriasis differentiation. ( 25323385 )
2014
43
Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study. ( 25473226 )
2014
44
Red face revisited: Endogenous dermatitis in the form of atopic dermatitis and seborrheic dermatitis. ( 24314384 )
2014
45
Refractory seborrheic dermatitis of the head in a patient with malignant lymphoma. ( 25566053 )
2014
46
Utilization of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry for identification of infantile seborrheic dermatitis-causing Malassezia and incidence of culture-based cutaneous Malassezia microbiota of 1-month-old infants. ( 24387229 )
2014
47
Treating seborrheic dermatitis: review of mechanisms and therapeutic options. ( 23884493 )
2013
48
Seborrheic dermatitis and hypertension in adults: a cross-sectional study. ( 24267636 )
2013
49
Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial. ( 24250695 )
2013
50
Double blind study of sertaconazole 2% cream vs. clotrimazole 1% cream in treatment of seborrheic dermatitis. ( 23829055 )
2013

Variations for Seborrheic Dermatitis

Expression for Seborrheic Dermatitis

Search GEO for disease gene expression data for Seborrheic Dermatitis.

Pathways for Seborrheic Dermatitis

GO Terms for Seborrheic Dermatitis

Biological processes related to Seborrheic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of organ growth GO:0046621 8.62 CGA STK4

Sources for Seborrheic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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