Seborrheic Dermatitis malady

Disease Ontology: A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast malassezia furfur. the symptoms include itching, skin lesions and scales, redness, plaques and hair loss.⁶

MalaCards: Seborrheic Dermatitis, also known as other seborrheic dermatitis, is related to dermatitis and acne. An important gene associated with Seborrheic Dermatitis is BTD (biotinidase). The drugs betamethasone acetate and pyrithione zinc and the compounds biotin and naringenin have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia: Seborrhoeic dermatitis (also seborrheic dermatitis AmE, seborrhea) (also known as \"seborrheic eczema\")...⁴⁴ more...

Aliases & Descriptions:

seborrheic dermatitis 6 8 32 43 other seborrheic dermatitis 6 43 other seborrheic dermatitis (disorder) 6 seborrheic dermatitis (disorder) 6 sebaceous gland overactivity 43 seborrheic dermatitis nos 6 seborrhea nos (disorder) 6

seborrhoeic dermatitis 6 seborrhea (disorder) 6 seborrhoeic eczema 6 skin seborrheic 6 seborrhoea 6 seborrhea 6

Diseases related to seborrheic dermatitis by text searches and GeneDecks gene sharing:

(show all 13)

id	Related Disease	Score	Top Affiliating Genes
1	dermatitis	27.6	AHR, SHBG, SETBP1, BTD, ZNF750
2	acne	27.1	BTD, SHBG
3	congenital hypothyroidism	12.6	BTD, SHBG
4	hypertrichosis	12.6	SHBG, SETBP1
5	adrenal hyperplasia	12.6	BTD, SHBG
6	glycogen storage disease	12.5	SHBG, BTD
7	alopecia	12.5	BTD, SHBG
8	ovarian endometriosis	12.2	SHBG, AHR
9	bilirubin metabolic disorder	12.2	BTD, SHBG
10	seborrheic infantile dermatitis	9.9
11	seborrhea-like dermatitis with psoriasiform elements	7.1
12	folliculitis	6.8
13	garret tripp syndrome	6.8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 betamethasone, betamethasone acetate, betamethasone benzoate, betamethasone dipropionate, betamethasone sodium phosphate, betamethasone valerate, betamethasone valerate pwdr [va product], chloroxine, coal tar, coal tar distillate, coal tar distillate [va product], coal tar extract, coal tar,colloidal, coal tar,crude, coal tar,refined, ketoconazole, pyrithione zinc, salicylic acid, salicylic acid pwdr [va product], selenium sulfide, sulfacetamide, sulfacetamide sodium, sulfur, sulfur pwdr [va product], sulfur,colloidal, sulfur,precipitated, zinc pyrithione

MalaCards organs/tissues related to seborrheic dermatitis:

²²

Articles related to seborrheic dermatitis:

id	Title	Authors	Year	Affiliating Genes
1	AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis. (18219281)	Gaitanis G.... Skaltsounis A.L.	2008	AHR
2	Biotin recycling impairment in phenylketonuric children with seborrheic dermatitis. (9888332)	Schulpis K.H.... Georgala S.	1998	BTD

Genes related to seborrheic dermatitis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	BTD	biotinidase	11.0	Publications
2	SHBG	sex hormone-binding globulin	11.0
3	ZNF750	zinc finger protein 750	11.0
4	AHR	aryl hydrocarbon receptor	11.0	Publications
5	SETBP1	SET binding protein 1	11.0

Compounds related to seborrheic dermatitis according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	biotin32 9 18 9	12.5	SHBG, BTD
2	naringenin32 9 9	11.3	SHBG, AHR
3	flutamide32 9 9	11.3	SHBG, AHR
4	progestin32	9.3	AHR, SHBG
5	atorvastatin32 34 9 18 9	13.2	SHBG, AHR
6	estrone32 9 18 9	12.2	SHBG, AHR
7	thyroxine32 18	10.1	SHBG, AHR
8	arginine32	8.6	BTD, SHBG, AHR
9	alanine32	8.4	BTD, SHBG, AHR

Biological processes related to seborrheic dermatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	9.4	ZNF750, BTD