MCID: SBR004
MIFTS: 39

Seborrheic Dermatitis malady

Categories: Skin diseases

Aliases & Classifications for Seborrheic Dermatitis

Aliases & Descriptions for Seborrheic Dermatitis:

Name: Seborrheic Dermatitis 12 29 52 14 69
Seborrhoeic Dermatitis 12
Dermatitis, Seborrheic 42
Seborrhoeic Eczema 12
Skin Seborrheic 12
Seborrhea 12

Classifications:



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Disease Ontology 12 DOID:8741
ICD10 33 L21 L21.9
ICD9CM 35 690.1 690.10 706.3
MeSH 42 D012628
NCIt 47 C111888
UMLS 69 C0036508

Summaries for Seborrheic Dermatitis

Disease Ontology : 12 A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss.

MalaCards based summary : Seborrheic Dermatitis, also known as seborrhoeic dermatitis, is related to seborrhea-like dermatitis with psoriasiform elements and seborrheic infantile dermatitis. An important gene associated with Seborrheic Dermatitis is BTD (Biotinidase). The drugs Salicylic acid and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and t cells, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Seborrheic dermatitis, also known as seborrheic eczema or simply as seborrhea, is a chronic, relapsing... more...

Related Diseases for Seborrheic Dermatitis

Graphical network of the top 20 diseases related to Seborrheic Dermatitis:



Diseases related to Seborrheic Dermatitis

Symptoms & Phenotypes for Seborrheic Dermatitis

GenomeRNAi Phenotypes related to Seborrheic Dermatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.84 SLCO2A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 SETBP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.84 SETBP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.84 SETBP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.84 IDH2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.84 SETBP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.84 SETBP1 SHBG SLCO2A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.84 IDH2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.84 IDH2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.84 SETBP1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.84 SETBP1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.84 SETBP1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.84 IDH2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.84 SHBG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 SLCO2A1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.84 SLCO2A1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.84 IDH2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.84 SHBG
19 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.84 SHBG
20 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.84 SHBG IDH2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.84 IDH2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.84 SETBP1 SLCO2A1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.84 SETBP1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.84 SETBP1

Drugs & Therapeutics for Seborrheic Dermatitis

Drugs for Seborrheic Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
3
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
4
Ciclopirox Approved, Investigational Phase 4,Phase 3 29342-05-0 2749
5
Tacrolimus Approved, Investigational Phase 4,Phase 3 104987-11-3 445643 439492
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
7
Ketoconazole Approved, Investigational Phase 4,Phase 3 65277-42-1 47576 3823
8
Drospirenone Approved Phase 4 67392-87-4 68873
9
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11 Analgesics Phase 4,Phase 2,Phase 1
12 Salicylates Phase 4
13 Cyclooxygenase Inhibitors Phase 4
14 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
15 Dermatologic Agents Phase 4,Phase 2,Phase 1
16 Hormone Antagonists Phase 4,Phase 3
17 Hormones Phase 4,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
20 Emollients Phase 4
21 Anti-Infective Agents Phase 4,Phase 3
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Antifungal Agents Phase 4,Phase 3
24 Keratolytic Agents Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
26 Antirheumatic Agents Phase 4,Phase 2,Phase 1
27 insulin Phase 4
28 Estradiol valerate Phase 4 979-32-8
29 diuretics Phase 4
30 Natriuretic Agents Phase 4
31 Steroid Synthesis Inhibitors Phase 4,Phase 3
32 Contraceptive Agents Phase 4,Phase 1,Phase 2
33 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
34 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
35 Trace Elements Phase 4
36 Diuretics, Potassium Sparing Phase 4
37 Drospirenone and ethinyl estradiol combination Phase 4
38 Vitamin B Complex Phase 4
39 Estradiol 17 beta-cypionate Phase 4
40 Estradiol 3-benzoate Phase 4
41 Vitamins Phase 4
42 Estrogens Phase 4
43 Polyestradiol phosphate Phase 4
44 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
45 Insulin, Globin Zinc Phase 4
46 Mineralocorticoid Receptor Antagonists Phase 4
47 Mineralocorticoids Phase 4
48 Micronutrients Phase 4
49 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
50 Folate Nutraceutical Phase 4

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea Unknown status NCT01139749 Phase 4
2 Promiseb Topical Cream for Cradle Cap Completed NCT01214434 Phase 4
3 Proactive Treatment of Tacrolimus Ointment for Adult Facial Seborrheic Dermatitis Completed NCT01591070 Phase 4
4 STUDY TO ASSESS THE LONG-TERM SAFETY OF EXTINA (KETOCONAZOLE) FOAM, 2% Completed NCT00703846 Phase 4
5 Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis Completed NCT00824863 Phase 4
6 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4
7 Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis Unknown status NCT01011621 Phase 3
8 Efficacy and Safety of ASF1057 in the Treatment of Seborrhoeic Dermatitis Completed NCT00565279 Phase 3
9 Two Topical K40 Formulations in Adults With Seborrhoeic Dermatitis (SD) of the Scalp Completed NCT01137630 Phase 2, Phase 3
10 Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis Completed NCT00862654 Phase 3
11 K301 for the Treatment of Seborrhoeic Eczema (SE) of the Scalp Completed NCT01137331 Phase 3
12 Tacrolimus Ointment Interest (PROTOPIC ®) in the Maintenance Treatment of Severe Seborrheic Dermatitis Recruiting NCT02004860 Phase 3
13 A 4 Week Study of Elidel for the Treatment of Seborrheic Dermatitis Completed NCT00403559 Phase 2
14 A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis of the Face Completed NCT00408330 Phase 2
15 Safety and Efficacy Study in Subjects With Seborrheic Dermatitis Completed NCT01703793 Phase 2
16 A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Seborrheic Dermatitis Completed NCT02749383 Phase 2
17 Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers Completed NCT01254162 Phase 2
18 The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage Completed NCT00991198 Phase 2
19 Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne Recruiting NCT03076320 Phase 1, Phase 2
20 Efficacy of Aerosal® in the Treatment of Inverse Psoriasis and Sebopsoriasis Withdrawn NCT01574872 Phase 2
21 Botulinum Toxin for Treatment of Seborrhic Dermatitis in Parkinsonian Patients Unknown status NCT00767546 Phase 1
22 Petrolatum's Effect on Initial Symptoms of Nonscalp Seborrheic Dermatitis and Preventing Exacerbation Unknown status NCT01315951
23 Evaluation of the Effectiveness of a Product Containing Topical Hydrocortisone in the Treatment of Seborrheic Dermatitis of the Face Unknown status NCT01024374
24 HIV Indicator Diseases Across Europe Study Unknown status NCT01681706
25 HIV Indicator Diseases Survey Across Europe - UK Arm Unknown status NCT01196468
26 HairMax LaserComb Open Label Study to Treat Seborrheic Dermatitis Completed NCT00830908
27 Neurobiology of the Scalp in Seborrheic Dermatitis Completed NCT02349854
28 Safety and Efficacy of SEBORRHEAMEDIS Face Cream in Patients With Seborrheic Dermatitis Completed NCT02656368
29 Seborrheic Dermatitis: Ketoconazole 2% Foam Versus Ketoconazole 2% Shampoo Completed NCT01203189
30 An Investigator-Initiated Study to Assess the Cooling Effect of Triamcinolone Acetonide Aerosol When Used for Steroid-Responsive Dermatoses Completed NCT01736670
31 Drug Utilization Study on Diane-35 (and Generics) in Three European Healthcare Databases Completed NCT02349399
32 Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis Recruiting NCT03114111
33 Furocyst - Poly Cystic Ovary Syndrome Study Recruiting NCT02703064
34 Drug Utilization Study on the Prescribing Indications for Cyproterone Acetate and Ethinyl Estradiol in 5 European Countries Recruiting NCT02494297

Search NIH Clinical Center for Seborrheic Dermatitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: dermatitis, seborrheic

Genetic Tests for Seborrheic Dermatitis

Genetic tests related to Seborrheic Dermatitis:

id Genetic test Affiliating Genes
1 Seborrheic Dermatitis 29

Anatomical Context for Seborrheic Dermatitis

MalaCards organs/tissues related to Seborrheic Dermatitis:

39
Skin, Tongue, T Cells

Publications for Seborrheic Dermatitis

Articles related to Seborrheic Dermatitis:

(show top 50) (show all 62)
id Title Authors Year
1
Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial. ( 27778328 )
2017
2
Malassezia arunalokei sp. nov., a Novel Yeast Species Isolated from Seborrheic Dermatitis Patients and Healthy Individuals from India. ( 27147721 )
2016
3
Prevalence and related factors of psoriasis and seborrheic dermatitis: a community-based study. ( 27511489 )
2016
4
Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp. ( 27489423 )
2016
5
Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. ( 27904273 )
2016
6
Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial. ( 27648378 )
2016
7
Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. ( 27804089 )
2016
8
Diffuse HIV-associated seborrheic dermatitis - a case series. ( 27013615 )
2016
9
Biofilm production and antifungal susceptibility of co-cultured Malassezia pachydermatis and Candida parapsilosis isolated from canine seborrheic dermatitis. ( 26868903 )
2016
10
Seborrheic dermatitis treatment with stellate ganglion block: a case report. ( 27064785 )
2016
11
Comprehensive pyrosequencing analysis of the bacterial microbiota of the skin of patients with seborrheic dermatitis. ( 27301664 )
2016
12
Noncorticosteroid Combination Shampoo versus 1% Ketoconazole Shampoo for the Management of Mild-to-Moderate Seborrheic Dermatitis of the Scalp: Results from a Randomized, Investigator-Single-Blind Trial Using Clinical and Trichoscopic Evaluation. ( 27171495 )
2016
13
Isolation and identification of Malassezia species from Chinese and Korean patients with seborrheic dermatitis and in vitro studies on their bioactivity on sebaceous lipids and IL-8 production. ( 26786542 )
2016
14
Loss of MPZL3 Function Causes Seborrheic Dermatitis-like Phenotype in Mice. ( 27488654 )
2016
15
Clinical manifestation and associated factors of seborrheic dermatitis in Korea. ( 26771150 )
2016
16
Dermoscopic findings in scalp psoriasis and seborrheic dermatitis; two new signs; signet ring vessel and hidden hair. ( 25657395 )
2015
17
Infantile seborrheic dermatitis: a pediatric Siddha medicine treatise. ( 25889138 )
2015
18
Clinical Characteristics and Quality of Life of Seborrheic Dermatitis Patients in a Tropical Country. ( 26538714 )
2015
19
Maintenance Therapy of Facial Seborrheic Dermatitis with 0.1% Tacrolimus Ointment. ( 26512166 )
2015
20
Topical anti-inflammatory agents for seborrheic dermatitis of the face or scalp: summary of a Cochrane Review. ( 25629391 )
2015
21
Evaluation of a Topical Anti-inflammatory/Antifungal Combination Cream in Mild-to-moderate Facial Seborrheic Dermatitis: An Intra-subject Controlled Trial Examining Treated vs. Untreated Skin Utilizing Clinical Features and Erythema-directed Digital Photography. ( 26430489 )
2015
22
Malassezia intra-specific diversity and potentially new species in the skin microbiota from Brazilian healthy subjects and seborrheic dermatitis patients. ( 25695430 )
2015
23
Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial. ( 26016699 )
2015
24
Seborrheic Dermatitis and Dandruff: A Comprehensive Review. ( 27148560 )
2015
25
Plica polonica secondary to seborrheic dermatitis. ( 26456757 )
2015
26
Diagnosis and treatment of seborrheic dermatitis. ( 25822272 )
2015
27
Refractory seborrheic dermatitis of the head in a patient with malignant lymphoma. ( 25566053 )
2014
28
Utilization of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry for identification of infantile seborrheic dermatitis-causing Malassezia and incidence of culture-based cutaneous Malassezia microbiota of 1-month-old infants. ( 24387229 )
2014
29
Reflectance confocal microscopy features of seborrheic dermatitis for plaque psoriasis differentiation. ( 25323385 )
2014
30
Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study. ( 25473226 )
2014
31
Red face revisited: Endogenous dermatitis in the form of atopic dermatitis and seborrheic dermatitis. ( 24314384 )
2014
32
Treatment of seborrheic dermatitis: the efficiency of sertaconazole 2% cream vs. tacrolimus 0.03% cream. ( 24171300 )
2013
33
Psychiatric comorbidities and alexithymia in patients with seborrheic dermatitis: a questionnaire study in Turkey. ( 23609607 )
2013
34
Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial. ( 24250695 )
2013
35
Evaluation of Expression of Lipases and Phospholipases of Malassezia restricta in Patients with Seborrheic Dermatitis. ( 24003273 )
2013
36
Retrospective Analysis of the Relationship Between Infantile Seborrheic Dermatitis and Atopic Dermatitis. ( 24224924 )
2013
37
Double blind study of sertaconazole 2% cream vs. clotrimazole 1% cream in treatment of seborrheic dermatitis. ( 23829055 )
2013
38
Treating seborrheic dermatitis: review of mechanisms and therapeutic options. ( 23884493 )
2013
39
Oxidative stress in patients with scalp seborrheic dermatitis. ( 24001414 )
2013
40
Seborrheic dermatitis and hypertension in adults: a cross-sectional study. ( 24267636 )
2013
41
Rational management of papulopustular rosacea with concomitant facial seborrheic dermatitis: a case report. ( 21278898 )
2011
42
Papulosquamous disorders: atopic dermatitis, psoriasis, seborrheic dermatitis, and nickel contact dermatitis. ( 21815450 )
2011
43
Follicular variant of seborrheic dermatitis: is it identical to Malassezia folliculitis? ( 21675495 )
2011
44
AhR ligands, malassezin, and indolo[3,2-b]carbazole are selectively produced by Malassezia furfur strains isolated from seborrheic dermatitis. ( 18219281 )
2008
45
Unilateral seborrheic dermatitis after decompression of Chiari I malformation and syringomyelia. ( 16844532 )
2006
46
Transient band-like keratopathy after treatment for seborrheic dermatitis. ( 15778610 )
2005
47
A novel T cell receptor transgenic animal model of seborrheic dermatitis-like skin disease. ( 15654969 )
2005
48
Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy. ( 14731170 )
2004
49
Superficial fungal infections: an update on pityriasis versicolor, seborrheic dermatitis, tinea capitis, and onychomycosis. ( 14678722 )
2003
50
Management of seborrheic dermatitis and pityriasis versicolor. ( 11702314 )
2000

Variations for Seborrheic Dermatitis

Expression for Seborrheic Dermatitis

Search GEO for disease gene expression data for Seborrheic Dermatitis.

Pathways for Seborrheic Dermatitis

GO Terms for Seborrheic Dermatitis

Biological processes related to Seborrheic Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 establishment of skin barrier GO:0061436 8.62 ABCA12 ALOX12B

Molecular functions related to Seborrheic Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 8.62 ABCA12 SLCO2A1

Sources for Seborrheic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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