MCID: SBR005
MIFTS: 48

Seborrheic Keratosis malady

Summaries for Seborrheic Keratosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A seborrheic keratosis (also known as \"seborrheic verruca,\" and \"senile wart\") is a noncancerous... more...

MalaCards: Seborrheic Keratosis, also known as keratosis seborrheica, is related to melanoma and squamous cell carcinoma. An important gene associated with Seborrheic Keratosis is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and TP53 network. The compounds vitamin a and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast, and related mouse phenotypes are endocrine/exocrine gland and integument.

Description from OMIM:46 182000

Aliases & Classifications for Seborrheic Keratosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

seborrheic keratosis 8 10 44 60
keratosis seborrheica 42
keratosis, seborrheic 42
seborrheic keratoses 42


Related Diseases for Seborrheic Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Seborrheic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.1NR1H2, DSG1, MAGED1, FGFR3, BCL2, TP63
2squamous cell carcinoma31.0RBP1, NR1H2, DSG1, FGFR3, BCL2, TP63
3adenocarcinoma30.4KLK8, BCL2, TP63, TGFB2
4psoriasis30.1KLK8, NR1H2, POU5F1
5keratosis11.3
6basal cell carcinoma10.8
7inflamed seborrheic keratosis10.5
8vulvar seborrheic keratosis10.5
9in situ carcinoma10.5
10actinic keratosis10.4
11epidermodysplasia verruciformis10.4
12acanthoma10.4
13inverted follicular keratosis10.4
14dermatosis papulosa nigra10.3
15lepromatous leprosy10.3
16leprosy10.3
17clear cell acanthoma10.3
18melanoacanthoma10.3
19cutaneous ganglioneuroma10.3
20lichen planus10.3
21ganglioneuroma10.3
22keratosis, seborrheic, somatic10.3
23neurofibromatosis10.2
24acanthosis nigricans10.2
25dysplastic nevus syndrome10.2
26pityriasis rubra pilaris10.2
27hypoglycemia10.2
28cheilitis10.2
29cryoglobulinemia10.1
30malignant conjunctiva melanoma10.1
31congenital ichthyosiform erythroderma10.1
32rosacea10.1
33folliculitis10.1
34pemphigus10.1
35follicular infundibulum tumor10.1
36fibroepithelial basal cell carcinoma10.1
37syringoma10.1
38eccrine porocarcinoma10.1
39mycosis fungoides10.1
40verrucous carcinoma10.1
41poems syndrome10.1
42porokeratosis10.1
43granuloma annulare10.1
44adenoiditis10.1
45alopecia10.1
46breast adenocarcinoma10.1
47breast disease10.1
48breast papillomatosis10.1
49myiasis10.1
50pigmentation disease10.1

Graphical network of the top 20 diseases related to Seborrheic Keratosis:



Diseases related to seborrheic keratosis

Clinical Features for Seborrheic Keratosis

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46OMIM
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Clinical features from OMIM:

182000

Drugs & Therapeutics for Seborrheic Keratosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Seborrheic Keratosis

Drug clinical trials:

Search ClinicalTrials for Seborrheic Keratosis

Search NIH Clinical Center for Seborrheic Keratosis

Search CenterWatch for Seborrheic Keratosis

Genetic Tests for Seborrheic Keratosis

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Anatomical Context for Seborrheic Keratosis

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32MalaCards
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MalaCards organs/tissues related to Seborrheic Keratosis:

32
Skin, Liver, Breast, Myeloid, T cells, Colon

Animal Models for Seborrheic Keratosis or affiliated genes

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36MGI
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Publications for Seborrheic Keratosis

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50PubMed
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Articles related to Seborrheic Keratosis:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. (23662587)
2013
2
Expression of Lumican in Hidroacanthoma Simplex and Clonal-Type Seborrheic Keratosis as a Potent Differential Diagnostic Marker. (23656908)
2013
3
Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy. (23415460)
2013
4
Case of seborrheic keratosis with underlying basal cell carcinoma suggesting a collision tumor. (23957647)
2013
5
Trichoblastoma shares cytokeratin 15-positive cells with seborrheic keratosis in a composite tumor--novel immunohistochemical findings. (23557961)
2013
6
Bowenoid transformation in seborrheic keratosis: A retrospective analysis of 429 patients. (23267371)
2012
7
Epidermal growth factor receptor expression in mice skin upon ultraviolet B exposure - Seborrheic Keratosis as a coincidental and unique finding. (23326790)
2012
8
Seborrheic keratosis of the external auditory canal in a 1-year-old boy. (23427523)
2012
9
Herpetic folliculitis in seborrheic keratosis of the head. (21752761)
2011
10
The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. (20185249)
2010
11
Malignant melanoma with a seborrheic keratosis-like clinical presentation. (20101348)
2009
12
Irritated seborrheic keratosis with coarse keratohyalin granules. (19942951)
2009
13
Seborrheic keratosis of the nasal vestibule. (18187992)
2007
14
Seborrheic keratosis with basal clear cells: a distinctive microscopic mimic of melanoma in situ. (16384768)
2006
15
Dermoscopy of lichenoid regressing seborrheic keratosis. (16549732)
2006
16
Pityrosporum and seborrheic keratosis: an association. (16150211)
2005
17
Primary cutaneous ganglioneuroma arising within a seborrheic keratosis: a rare association. (15725239)
2005
18
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
19
Melanoma within the seborrheic keratosis. (15056152)
2004
20
Frequency of seborrheic keratosis biopsies in the United States: a benchmark of skin lesion care quality and cost effectiveness. (12859377)
2003
21
Melanoma simulating seborrheic keratosis: a major dermoscopy pitfall. (12622648)
2003
22
Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. (12827609)
2003
23
Giant lobulated seborrheic keratosis at an unusual site. (15027742)
2003
24
Melanoma and seborrheic keratosis differentiation using texture features. (14641886)
2003
25
Seborrheic keratosis of the auricle: report of an unusual case. (11868470)
2002
26
Apoptosis in the areas of squamous differentiation of irritated seborrheic keratosis. (10728813)
2000
27
Superficial spreading (and disappearing) seborrheic keratosis. (10228754)
1999
28
Pigmented and nested sebomatricoma or seborrheic keratosis with sebaceous differentiation? (9700378)
1998
29
Conservative clinical diagnoses in seborrheic keratosis. (9645652)
1998
30
Occult basal cell carcinoma arising in seborrheic keratosis. (9675344)
1998
31
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
32
Two cases of basal cell carcinoma arising in seborrheic keratosis. (9198322)
1997
33
A naturally occurring ring seborrheic keratosis. (8864384)
1996
34
Seborrheic keratosis with trichilemmomas masquerading as melanoma. (7835066)
1994
35
Amyloid in basal cell carcinoma and seborrheic keratosis. (7976084)
1994
36
Seborrheic keratosis-like lesions in epidermodysplasia verruciformis. (8396161)
1993
37
Acantholytic variant of seborrheic keratosis. (2138642)
1990
38
Pathologic quiz case 1. Seborrheic keratosis, irritated type. (2765240)
1989
39
Seborrheic keratosis with possible central regression. (2529103)
1989
40
Squamous cell carcinoma in situ (Bowen's disease) arising in seborrheic keratosis: three lesions in two patients. (2533222)
1989
41
Multiple small papular seborrheic keratosis. (2976363)
1988
42
Seborrheic keratosis? (3965523)
1985
43
Langerhans' cells in seborrheic keratosis. A clinical and ultrastructural study. (2413689)
1985
44
Dermabrasion for the treatment of a giant seborrheic keratosis. (3159772)
1985
45
Giant irritated seborrheic keratosis mimicking verrucous carcinoma. (3910690)
1985
46
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
47
Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. (6229188)
1983
48
Giant pedunculated seborrheic keratosis. (443844)
1979
49
Seborrheic keratosis: an acantholytic variant. (150429)
1978
50
SEBORRHEIC KERATOSIS OR BASAL CELL CARCINOMA?A CASE REPORT. (14177642)
1964

Genetic Variations for Seborrheic Keratosis

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Expression for genes affiliated with Seborrheic Keratosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seborrheic Keratosis

Search GEO for disease gene expression data for Seborrheic Keratosis.

Pathways for genes affiliated with Seborrheic Keratosis

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52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TGFB2, BCL2
29.8TP63, BCL2
39.2TGFB2, TP63, BCL2, FGFR3

Compounds for genes affiliated with Seborrheic Keratosis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2411.8TGFB2, NR1H2
2cd 437449.8BCL2, NR1H2
3noxa449.5TP63, BCL2
4retinaldehyde449.4NR1H2, RBP1
5acitretin44 1110.4RBP1, NR1H2
6n-(4-hydroxyphenyl)retinamide449.2BCL2, NR1H2, RBP1
7steroid448.8TGFB2, NR1H2, RBP1, KLK8
8vegf448.7NR1H2, POU5F1, FGFR3, BCL2, TP63, TGFB2
9serine448.7KLK8, NR1H2, DSG1, FGFR3, BCL2, TGFB2
10paraffin448.7RBP1, FGFR3, BCL2, TP63, TGFB2
11progesterone44 59 28 11 2412.5RBP1, NR1H2, BCL2, TP63, TGFB2
12retinoic acid44 248.9TGFB2, TP63, BCL2, POU5F1, DSG1, NR1H2

GO Terms for genes affiliated with Seborrheic Keratosis

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16Gene Ontology
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Biological processes related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:04854610.0FGFR3, BCL2
2response to progesterone stimulusGO:03257010.0DSG1, TGFB2
3keratinocyte proliferationGO:0436169.9TP63, KLK8
4cell agingGO:0075699.8TP63, BCL2
5neuron apoptotic processGO:0514029.8TP63, BCL2
6hair follicle morphogenesisGO:0310699.7TP63, TGFB2, BCL2
7developmental growthGO:0485899.7BCL2, TBCE
8negative regulation of epithelial cell proliferationGO:0506809.7FGFR3, TGFB2, MAGED1
9response to woundingGO:0096119.5TGFB2, KLK8, POU5F1
10cell deathGO:0082199.5KLK8, BCL2, TGFB2
11response to gamma radiationGO:0103329.5BCL2, TP63

Molecular functions related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0TP63, BCL2, POU5F1, NR1H2

Products for genes affiliated with Seborrheic Keratosis

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Sources for Seborrheic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet