MCID: SBR005
MIFTS: 52

Seborrheic Keratosis malady

Rare diseases, Skin diseases categories
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Summaries for Seborrheic Keratosis

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Wikipedia:65 A seborrheic keratosis (also known as \"seborrheic verruca,\" and \"senile wart\") is a noncancerous... more...

MalaCards based summary: Seborrheic Keratosis, also known as keratosis seborrheica, is related to psoriasis and adenocarcinoma. An important gene associated with Seborrheic Keratosis is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Endochondral Ossification and ATF-2 transcription factor network. The compounds p005 and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Description from OMIM:46 182000

Aliases & Classifications for Seborrheic Keratosis

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Seborrheic Keratosis, Aliases & Descriptions:

Name: Seborrheic Keratosis 8 10 44 62
Keratosis Seborrheica 42 62
 
Keratosis, Seborrheic 42
Seborrheic Keratoses 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Related Diseases for Seborrheic Keratosis

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Graphical network of the top 20 diseases related to Seborrheic Keratosis:



Diseases related to seborrheic keratosis

Symptoms for Seborrheic Keratosis

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Clinical features from OMIM:

182000

Drugs & Therapeutics for Seborrheic Keratosis

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Drug clinical trials:

Search ClinicalTrials for Seborrheic Keratosis

Search NIH Clinical Center for Seborrheic Keratosis

Genetic Tests for Seborrheic Keratosis

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Anatomical Context for Seborrheic Keratosis

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MalaCards organs/tissues related to Seborrheic Keratosis:

32
Skin, Liver, Breast, Colon, Myeloid, T cells

Animal Models for Seborrheic Keratosis or affiliated genes

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Publications for Seborrheic Keratosis

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Articles related to Seborrheic Keratosis:

(show top 50)    (show all 219)
idTitleAuthorsYear
1
Association of Dowling-Degos disease and multiple seborrheic keratosis in a "Christmas tree pattern". (25405133)
2014
2
Dermatofibroma with seborrheic keratosis-like changes: a dermoscopic challenge. Diagnosis: Dermatofibroma with seborrheic keratosis-like changes. (25219724)
2014
3
Clonal seborrheic keratosis versus epidermal nevus. (23866887)
2013
4
Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. (23662587)
2013
5
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
6
Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (22236073)
2012
7
Bowenoid transformation in seborrheic keratosis: A retrospective analysis of 429 patients. (23267371)
2012
8
Seborrheic keratosis of the external auditory canal. (22090002)
2012
9
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
10
Seborrheic keratosis, keratotic type, of the external auditory canal. (21636843)
2011
11
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
12
A case of irritated seborrheic keratosis associated with a previous incision site. (20532145)
2010
13
Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. (20425131)
2010
14
The vasculature of nonmelanocytic skin tumors in reflectance confocal microscopy, II: Vascular features of seborrheic keratosis. (20566947)
2010
15
Malignant melanoma with a seborrheic keratosis-like clinical presentation. (20101348)
2009
16
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
17
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
18
Giant genital seborrheic keratosis or Buschke LAPwenstein tumor? (18823349)
2008
19
Squamous eddies in irritated seborrheic keratosis. (17284959)
2007
20
Vulvar seborrheic keratosis. (18053380)
2007
21
Overexpression of p27KIP1 in seborrheic keratosis. (17942027)
2007
22
Pityrosporum and seborrheic keratosis: an association. (16150211)
2005
23
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
24
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. (15128703)
2004
25
"Globulelike" dermoscopic structures in pigmented seborrheic keratosis. (14732676)
2004
26
Desmoplastic seborrheic keratosis. (12775983)
2003
27
Frequency of seborrheic keratosis biopsies in the United States: a benchmark of skin lesion care quality and cost effectiveness. (12859377)
2003
28
Dermoscopic diagnosis of seborrheic keratosis. (12074865)
2002
29
Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. (12472343)
2002
30
Sebaceoma arising in association with seborrheic keratosis. (11176054)
2001
31
Compare your diagnosis. Xanthogranuloma, seborrheic keratosis associated with mycosis fungoides, Kikuchi's disease. (10027533)
1999
32
A case of seborrheic keratosis distributed along skin cleavage lines. (9609989)
1998
33
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
34
Malignant melanoma simulating a seborrheic keratosis: a case report. (9141366)
1997
35
Globulelike dermoscopic structures in pigmented seborrheic keratosis. (9126023)
1997
36
Dermacase. Seborrheic keratosis. (8081119)
1994
37
Clinical misdiagnosis of melanoma as well as squamous cell carcinoma masquerading as seborrheic keratosis. (8151040)
1994
38
Seborrheic keratosis with trichilemmomas masquerading as melanoma. (7835066)
1994
39
Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction. (1337468)
1992
40
Acantholytic variant of seborrheic keratosis. (2138642)
1990
41
Seborrheic keratosis with focal acantholysis. (2470800)
1989
42
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
43
Multiple small papular seborrheic keratosis. (2976363)
1988
44
Seborrheic keratosis? (3965523)
1985
45
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
46
Seborrheic keratosis and papillomatosis: markers of breast adenocarcinoma. (6225626)
1983
47
Squamous cell carcinoma arising in seborrheic keratosis. (6970889)
1981
48
A tridimensional view of seborrheic keratosis. (6447911)
1980
49
Treatment of seborrheic keratosis. (4247377)
1970
50
Seborrheic keratosis and verruca, with special reference to the melanotic variety. (14810197)
1951

Variations for Seborrheic Keratosis

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Expression for genes affiliated with Seborrheic Keratosis

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Expression patterns in normal tissues for genes affiliated with Seborrheic Keratosis

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Pathways for genes affiliated with Seborrheic Keratosis

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Compounds for genes affiliated with Seborrheic Keratosis

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Compounds related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1p005449.9TGFB2, TP63
2cd 437449.8BCL2, NR1H2
3noxa449.8BCL2, TP63
4n-(4-hydroxyphenyl)retinamide449.5BCL2, NR1H2
5tamoxifen44 50 28 1112.5NR1H2, BCL2, TGFB2
6mptp449.4TGFB2, BCL2
7genistein44 28 61 2 24 1114.3TGFB2, BCL2, NR1H2
8doxorubicin44 50 1111.3TP63, FGFR3, BCL2
9paraffin449.3TP63, TGFB2, BCL2, FGFR3
10dexamethasone44 50 28 1112.3TGFB2, BCL2, NR1H2, FGFR3
11glutamate449.3FGFR3, NR1H2, TGFB2, TP63
12progesterone44 28 61 24 1113.2TP63, TGFB2, BCL2, NR1H2
13steroid449.1TGFB2, KLK8, NR1H2, TP63
14estrogen449.0BCL2, TP63, TGFB2, NR1H2
15vegf448.6FGFR3, TP63, TGFB2, POU5F1, BCL2, NR1H2
16retinoic acid44 249.6TP63, POU5F1, DSG1, BCL2, NR1H2, TGFB2
17serine448.5BCL2, FGFR3, KLK8, TGFB2, NR1H2, DSG1

GO Terms for genes affiliated with Seborrheic Keratosis

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Cellular components related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.8FGFR3, DSG1
2chromatinGO:0007859.5MAGED1, TP63
3nucleoplasmGO:0056548.4NR1H2, MED10, POU5F1, TP63

Biological processes related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:04854610.0BCL2, FGFR3
2response to progesteroneGO:03257010.0DSG1, TGFB2
3somatic stem cell maintenanceGO:0350199.8FGFR3, POU5F1
4cell agingGO:0075699.8TP63, BCL2
5keratinocyte proliferationGO:0436169.8KLK8, TP63
6response to gamma radiationGO:0103329.8BCL2, TP63
7positive regulation of neuron apoptotic processGO:0435259.8FGFR3, TGFB2
8positive regulation of cell growthGO:0303079.7TGFB2, BCL2
9positive regulation of apoptotic signaling pathwayGO:20012359.7TP63, MAGED1
10neuron apoptotic processGO:0514029.7TP63, BCL2
11negative regulation of epithelial cell proliferationGO:0506809.7MAGED1, TGFB2, FGFR3
12hair follicle morphogenesisGO:0310699.6BCL2, TP63, TGFB2
13response to woundingGO:0096119.6KLK8, POU5F1, TGFB2
14cell deathGO:0082199.5TGFB2, BCL2, KLK8
15cell growthGO:0160499.4BCL2, TGFB2
16apoptotic processGO:0069159.0DSG1, BCL2, TP63, MAGED1
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TP63, MED10, NR1H2, POU5F1

Molecular functions related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435658.6TP63, POU5F1, BCL2, NR1H2
2protein bindingGO:0055157.3TP63, TGFB2, POU5F1, MAGED1, BCL2, NR1H2

Products for genes affiliated with Seborrheic Keratosis

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Sources for Seborrheic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet