MCID: SBR005
MIFTS: 48

Seborrheic Keratosis malady

Summaries for Seborrheic Keratosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A seborrheic keratosis (also known as \"seborrheic verruca,\" and \"senile wart\") is a noncancerous... more...

MalaCards: Seborrheic Keratosis, also known as keratosis seborrheica, is related to melanoma and squamous cell carcinoma. An important gene associated with Seborrheic Keratosis is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and TP53 network. The compounds vitamin a and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast, and related mouse phenotypes are endocrine/exocrine gland and integument.

Description from OMIM:46 182000

Aliases & Classifications for Seborrheic Keratosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

seborrheic keratosis 8 10 44 60
keratosis seborrheica 42
keratosis, seborrheic 42
seborrheic keratoses 42


Related Diseases for Seborrheic Keratosis

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17GeneCards, 18GeneDecks
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Diseases related to Seborrheic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.1NR1H2, DSG1, MAGED1, FGFR3, BCL2, TP63
2squamous cell carcinoma31.0RBP1, NR1H2, DSG1, FGFR3, BCL2, TP63
3adenocarcinoma30.4KLK8, BCL2, TP63, TGFB2
4psoriasis30.1KLK8, NR1H2, POU5F1
5keratosis11.3
6basal cell carcinoma10.8
7inflamed seborrheic keratosis10.5
8vulvar seborrheic keratosis10.5
9in situ carcinoma10.5
10actinic keratosis10.4
11epidermodysplasia verruciformis10.4
12acanthoma10.4
13inverted follicular keratosis10.4
14dermatosis papulosa nigra10.3
15lepromatous leprosy10.3
16leprosy10.3
17clear cell acanthoma10.3
18melanoacanthoma10.3
19cutaneous ganglioneuroma10.3
20lichen planus10.3
21ganglioneuroma10.3
22keratosis, seborrheic, somatic10.3
23neurofibromatosis10.2
24acanthosis nigricans10.2
25dysplastic nevus syndrome10.2
26pityriasis rubra pilaris10.2
27hypoglycemia10.2
28cheilitis10.2
29cryoglobulinemia10.1
30malignant conjunctiva melanoma10.1
31congenital ichthyosiform erythroderma10.1
32rosacea10.1
33folliculitis10.1
34pemphigus10.1
35follicular infundibulum tumor10.1
36fibroepithelial basal cell carcinoma10.1
37syringoma10.1
38eccrine porocarcinoma10.1
39mycosis fungoides10.1
40verrucous carcinoma10.1
41poems syndrome10.1
42porokeratosis10.1
43granuloma annulare10.1
44adenoiditis10.1
45alopecia10.1
46breast adenocarcinoma10.1
47breast disease10.1
48breast papillomatosis10.1
49myiasis10.1
50pigmentation disease10.1

Graphical network of the top 20 diseases related to Seborrheic Keratosis:



Diseases related to seborrheic keratosis

Clinical Features for Seborrheic Keratosis

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46OMIM
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Clinical features from OMIM:

182000

Drugs & Therapeutics for Seborrheic Keratosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Seborrheic Keratosis

Drug clinical trials:

Search ClinicalTrials for Seborrheic Keratosis

Search NIH Clinical Center for Seborrheic Keratosis

Search CenterWatch for Seborrheic Keratosis

Genetic Tests for Seborrheic Keratosis

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Anatomical Context for Seborrheic Keratosis

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32MalaCards
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MalaCards organs/tissues related to Seborrheic Keratosis:

32
Skin, Liver, Breast, Colon, Myeloid, T cells

Animal Models for Seborrheic Keratosis or affiliated genes

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36MGI
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Publications for Seborrheic Keratosis

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50PubMed
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Articles related to Seborrheic Keratosis:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Clonal seborrheic keratosis versus epidermal nevus. (23866887)
2013
2
Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification. (23786588)
2013
3
Clonal seborrheic keratosis: dermoscopic and confocal microscopy characterization. (24033484)
2013
4
Malignant hidroacanthoma simplex: arising in hidroacanthoma simplex mimicking clonal seborrheic keratosis. (22353024)
2013
5
Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (22236073)
2012
6
Association between melanocytic neoplasms and seborrheic keratosis: more than a coincidental collision? (23785597)
2012
7
Giant seborrheic keratosis of the genitalia. (22837573)
2012
8
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
9
Seborrheic keratosis, keratotic type, of the external auditory canal. (21636843)
2011
10
Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. (21602158)
2011
11
Increased glucose uptake by seborrheic keratosis detected by positron emission tomography. (21175767)
2011
12
Seborrheic keratosis of the external auditory canal. (22033969)
2011
13
Human papillomavirus-induced lesions on tattoos may show features of seborrheic keratosis. (21422356)
2011
14
What caused this spotted, itchy rash on the shins? Seborrheic keratosis. (21534378)
2011
15
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
16
A case of irritated seborrheic keratosis associated with a previous incision site. (20532145)
2010
17
Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy. (21039905)
2010
18
Myiasis in a large perigenital seborrheic keratosis. (21063538)
2010
19
Ungual seborrheic keratosis. (20180892)
2010
20
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
21
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
22
Giant genital seborrheic keratosis or Buschke LAPwenstein tumor? (18823349)
2008
23
Multiple facial seborrheic keratosis-like lesions in a young woman with epidermodysplasia verruciformis. (18412865)
2008
24
Giant pedunculated seborrheic keratosis of penis. (19967020)
2008
25
Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma. (17433176)
2007
26
Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. (16972954)
2006
27
Seborrheic keratosis-like porokeratosis: a case report. (15748559)
2005
28
Differentiation of hidroacanthoma simplex from clonal seborrheic keratosis--an immunohistochemical study. (15166504)
2004
29
Lidocaine iontophoresis versus EMLA cream for CO2 laser treatment in seborrheic keratosis. (16083154)
2004
30
Seborrheic keratosis of the conjunctiva. (15283223)
2004
31
Gigantic metameric seborrheic keratosis. (12900651)
2003
32
Seborrheic Keratosis-like lesions in patients with epidermodysplasia verruciformis. (12598709)
2003
33
Pemphigus foliaceus presenting as eruptive seborrheic keratosis and responding to oral gold treatment. (12851996)
2002
34
Sebaceoma arising in association with seborrheic keratosis. (11176054)
2001
35
Absence of human papillomavirus DNA in nongenital seborrheic keratosis. (11641533)
2001
36
Malignant melanoma arising in a seborrheic keratosis. (10775864)
2000
37
Compare your diagnosis. Xanthogranuloma, seborrheic keratosis associated with mycosis fungoides, Kikuchi's disease. (10027533)
1999
38
A solitary cutaneous tumor with distinct areas of verruca and seborrheic keratosis-like lesion. (10607930)
1999
39
Malignant melanoma simulating a seborrheic keratosis: a case report. (9141366)
1997
40
A possible case of eccrine poroma arising in seborrheic keratosis with partial intermediate malignancy and tumor of the follicular infundibulum. (9375465)
1997
41
Diagnosis and treatment of seborrheic keratosis. (1826534)
1991
42
Adenocarcinoma arising in a seborrheic keratosis. (1835342)
1991
43
Human papillomavirus (HPV) infection in seborrheic keratosis. (2543229)
1989
44
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis. (3286780)
1988
45
Stereological study of desmosomes in basal cell carcinoma and seborrheic keratosis. (2955125)
1987
46
An acantholytic variant of seborrheic keratosis. (2946737)
1986
47
Seborrheic keratosis and papillomatosis: markers of breast adenocarcinoma. (6225626)
1983
48
Inverted follicular keratosis is an irritated seborrheic keratosis. (6229190)
1983
49
Transformation of seborrheic keratosis into Bowen's disease. (154527)
1978
50
Seborrheic keratosis of penis. (4275401)
1974

Genetic Variations for Seborrheic Keratosis

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Expression for genes affiliated with Seborrheic Keratosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seborrheic Keratosis

Search GEO for disease gene expression data for Seborrheic Keratosis.

Pathways for genes affiliated with Seborrheic Keratosis

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52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TGFB2, BCL2
29.8TP63, BCL2
39.2TGFB2, TP63, BCL2, FGFR3

Compounds for genes affiliated with Seborrheic Keratosis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2411.8TGFB2, NR1H2
2cd 437449.8BCL2, NR1H2
3noxa449.5TP63, BCL2
4retinaldehyde449.4NR1H2, RBP1
5acitretin44 1110.4RBP1, NR1H2
6n-(4-hydroxyphenyl)retinamide449.2BCL2, NR1H2, RBP1
7steroid448.8TGFB2, NR1H2, RBP1, KLK8
8vegf448.7NR1H2, POU5F1, FGFR3, BCL2, TP63, TGFB2
9serine448.7KLK8, NR1H2, DSG1, FGFR3, BCL2, TGFB2
10paraffin448.7RBP1, FGFR3, BCL2, TP63, TGFB2
11progesterone44 59 28 11 2412.5RBP1, NR1H2, BCL2, TP63, TGFB2
12retinoic acid44 248.9TGFB2, TP63, BCL2, POU5F1, DSG1, NR1H2

GO Terms for genes affiliated with Seborrheic Keratosis

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16Gene Ontology
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Biological processes related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:04854610.0BCL2, FGFR3
2response to progesterone stimulusGO:03257010.0TGFB2, DSG1
3keratinocyte proliferationGO:0436169.9TP63, KLK8
4cell agingGO:0075699.8TP63, BCL2
5neuron apoptotic processGO:0514029.8TP63, BCL2
6hair follicle morphogenesisGO:0310699.7TGFB2, TP63, BCL2
7developmental growthGO:0485899.7TBCE, BCL2
8negative regulation of epithelial cell proliferationGO:0506809.7TGFB2, FGFR3, MAGED1
9response to woundingGO:0096119.5KLK8, POU5F1, TGFB2
10cell deathGO:0082199.5KLK8, BCL2, TGFB2
11response to gamma radiationGO:0103329.5BCL2, TP63

Molecular functions related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0TP63, BCL2, POU5F1, NR1H2

Products for genes affiliated with Seborrheic Keratosis

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Sources for Seborrheic Keratosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet