MCID: SBR005
MIFTS: 44

Seborrheic Keratosis malady

Summaries for Seborrheic Keratosis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 A seborrheic keratosis (also known as \"seborrheic verruca,\" and \"senile wart\") is a noncancerous... more...

MalaCards: Seborrheic Keratosis, also known as keratosis seborrheica, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Seborrheic Keratosis is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and TP53 network. The compounds vitamin a and cd 437 have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and integument.

Description from OMIM:47 182000

Aliases & Classifications for Seborrheic Keratosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 47OMIM, 35MeSH, 40NCIt, 27ICD9CM
See all sources

Aliases & Descriptions:

seborrheic keratosis 8 10 45 61
keratosis seborrheica 43
keratosis, seborrheic 43
seborrheic keratoses 43


Related Diseases for Seborrheic Keratosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Seborrheic Keratosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.0RBP1, NR1H2, DSG1, TP63, TGFB2, FGFR3
2adenocarcinoma30.4TP63, BCL2, KLK8, TGFB2
3basal cell carcinoma10.8
4inflamed seborrheic keratosis10.5
5vulvar seborrheic keratosis10.5
6actinic keratosis10.4
7epidermodysplasia verruciformis10.4
8acanthoma10.4
9dermatosis papulosa nigra10.3
10lepromatous leprosy10.3
11clear cell acanthoma10.3
12melanoacanthoma10.3
13cutaneous ganglioneuroma10.3
14lichen planus10.3
15ganglioneuroma10.3
16lentigo maligna melanoma10.3
17keratosis, seborrheic, somatic10.3
18neurofibromatosis10.2
19acanthosis nigricans10.2
20dysplastic nevus syndrome10.2
21pityriasis rubra pilaris10.2
22hypoglycemia10.2
23n syndrome10.2
24actinic cheilitis10.2
25kindler syndrome10.2
26trichostasis spinulosa10.2
27solitary fibrous tumor10.2
28pemphigus erythematosus10.2
29cryoglobulinemia10.1
30malignant conjunctiva melanoma10.1
31congenital ichthyosiform erythroderma10.1
32rosacea10.1
33folliculitis10.1
34anal carcinoma in situ10.1
35pemphigus10.1
36follicular infundibulum tumor10.1
37fibroepithelial basal cell carcinoma10.1
38syringoma10.1
39eccrine porocarcinoma10.1
40mycosis fungoides10.1
41verrucous carcinoma10.1
42poems syndrome10.1
43porokeratosis10.1
44granuloma annulare10.1
45alopecia10.1
46anal squamous cell carcinoma10.1
47breast adenocarcinoma10.1
48skin squamous cell carcinoma10.1
49degos disease10.1
50basal cell carcinoma, multiple10.1

Graphical network of the top 20 diseases related to Seborrheic Keratosis:



Diseases related to seborrheic keratosis

Clinical Features for Seborrheic Keratosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

182000

Drugs & Therapeutics for Seborrheic Keratosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Seborrheic Keratosis

Drug clinical trials:

Search ClinicalTrials for Seborrheic Keratosis

Search NIH Clinical Center for Seborrheic Keratosis

Search CenterWatch for Seborrheic Keratosis

Genetic Tests for Seborrheic Keratosis

Anatomical Context for Seborrheic Keratosis

Animal Models for Seborrheic Keratosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Seborrheic Keratosis

Sources:
51PubMed
See all sources

Articles related to Seborrheic Keratosis:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Expression of Lumican in Hidroacanthoma Simplex and Clonal-Type Seborrheic Keratosis as a Potent Differential Diagnostic Marker. (23656908)
2013
2
Development of a novel therapeutic approach using a retinoic acid-loaded microneedle patch for seborrheic keratosis treatment and safety study in humans. (23791975)
2013
3
Case of seborrheic keratosis with underlying basal cell carcinoma suggesting a collision tumor. (23957647)
2013
4
Seborrheic keratosis with basal clear cells: a peculiar microscopic mimic of melanoma in situ. (23590805)
2013
5
Seborrheic keratosis of the vulva clinically mimicking a genital wart: a case study. (22171841)
2013
6
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
7
Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (22236073)
2012
8
Seborrheic keratosis of the external auditory canal. (22710550)
2012
9
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
10
Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. (21602158)
2011
11
Seborrheic keratosis of the external auditory canal. (22033969)
2011
12
Human papillomavirus-induced lesions on tattoos may show features of seborrheic keratosis. (21422356)
2011
13
Key points in dermoscopic diagnosis of basal cell carcinoma and seborrheic keratosis in Japanese. (21175757)
2011
14
Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. (20425131)
2010
15
The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. (20185249)
2010
16
Studying regression of seborrheic keratosis in lichenoid keratosis with sequential dermoscopy imaging. (19996577)
2010
17
Seborrheic keratosis of the conjunctiva: a case report. (20046694)
2009
18
Giant pedunculated seborrheic keratosis of penis. (19967020)
2008
19
Diagnostic quiz. Case No. 1: seborrheic keratosis. (17708041)
2007
20
Giant genital seborrheic keratosis. (17958589)
2007
21
Pigmented malignant hidroacanthoma simplex mimicking irritated seborrheic keratosis. (17026524)
2006
22
Desmoplastic seborrheic keratosis. (12775983)
2003
23
Frequency of seborrheic keratosis biopsies in the United States: a benchmark of skin lesion care quality and cost effectiveness. (12859377)
2003
24
Gigantic metameric seborrheic keratosis. (12655244)
2003
25
Dermoscopic diagnosis of seborrheic keratosis. (12074865)
2002
26
Seborrheic keratosis with compound nevus, junctional nevus and basal cell carcinoma in the same lesion. (11701986)
2001
27
A case of seborrheic keratosis distributed along skin cleavage lines. (9609989)
1998
28
Pigmented and nested sebomatricoma or seborrheic keratosis with sebaceous differentiation? (9700378)
1998
29
Squamous cell carcinoma arising within seborrheic keratosis. (9703085)
1998
30
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
31
Malignant melanoma simulating a seborrheic keratosis: a case report. (9141366)
1997
32
Anti-tumor effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in seborrheic keratosis. (9627701)
1996
33
Dermacase. Seborrheic keratosis. (8495115)
1993
34
Simple epithelial cytokeratin-expression in seborrheic keratosis. (1282137)
1992
35
Benign pigmented tumor with combined features of seborrheic keratosis and compound nevus. (1836990)
1991
36
Seborrheic keratosis with Sutton's phenomenon. (1837036)
1991
37
Acantholytic variant of seborrheic keratosis. (2138642)
1990
38
Simultaneous occurrence of junctional nevus and seborrheic keratosis. (2533059)
1989
39
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
40
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis. (3286780)
1988
41
Seborrheic keratosis of the ear canal. (2960940)
1987
42
Differentiating seborrheic keratosis from skin neoplasm. (4007500)
1985
43
Dermabrasion for the treatment of a giant seborrheic keratosis. (3159772)
1985
44
Trichilemmal neoplasm developing in seborrheic keratosis--report of two cases. (3161921)
1985
45
Halo seborrheic keratosis. (6874189)
1983
46
The relationship of seborrheic keratosis and basal-cell carcinoma? (6224829)
1983
47
Seborrheic keratosis with epidermal cyst. (6967174)
1980
48
Seborrheic keratosis of penis. (4275401)
1974
49
Tumor of the ear canal. Seborrheic keratosis. (5409719)
1970
50
Histophotometric investigation of the nuclear DNA-content in normal epidermis, seborrheic keratosis, keratosis senilis, squamous cell carcinoma and basal cell carcinoma. (14032933)
1963

Genetic Variations for Seborrheic Keratosis

Expression for genes affiliated with Seborrheic Keratosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Seborrheic Keratosis

Search GEO for disease gene expression data for Seborrheic Keratosis.

Pathways for genes affiliated with Seborrheic Keratosis

Sources:
53R&D Systems, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TGFB2, BCL2
29.8TP63, BCL2
39.2TGFB2, TP63, BCL2, FGFR3

Compounds for genes affiliated with Seborrheic Keratosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1vitamin a45 11 2411.8NR1H2, TGFB2
2cd 437459.8NR1H2, BCL2
3noxa459.5BCL2, TP63
4retinaldehyde459.4RBP1, NR1H2
5acitretin45 1110.4NR1H2, RBP1
6n-(4-hydroxyphenyl)retinamide459.2BCL2, NR1H2, RBP1
7steroid458.8RBP1, NR1H2, KLK8, TGFB2
8vegf458.7NR1H2, POU5F1, TGFB2, TP63, BCL2, FGFR3
9serine458.7NR1H2, TGFB2, FGFR3, KLK8, BCL2, DSG1
10paraffin458.7BCL2, FGFR3, RBP1, TGFB2, TP63
11progesterone45 60 29 11 2412.5RBP1, NR1H2, BCL2, TP63, TGFB2
12retinoic acid45 248.9TGFB2, RBP1, NR1H2, DSG1, POU5F1, BCL2

GO Terms for genes affiliated with Seborrheic Keratosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:04854610.0FGFR3, BCL2
2response to progesterone stimulusGO:03257010.0DSG1, TGFB2
3keratinocyte proliferationGO:0436169.9TP63, KLK8
4cell agingGO:0075699.8TP63, BCL2
5neuron apoptotic processGO:0514029.8TP63, BCL2
6hair follicle morphogenesisGO:0310699.7TP63, TGFB2, BCL2
7developmental growthGO:0485899.7BCL2, TBCE
8negative regulation of epithelial cell proliferationGO:0506809.7FGFR3, TGFB2, MAGED1
9response to woundingGO:0096119.5TGFB2, KLK8, POU5F1
10cell deathGO:0082199.5KLK8, BCL2, TGFB2
11response to gamma radiationGO:0103329.5BCL2, TP63

Molecular functions related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0TP63, BCL2, POU5F1, NR1H2

Products for genes affiliated with Seborrheic Keratosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Seborrheic Keratosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet