MCID: SBR005
MIFTS: 52

Seborrheic Keratosis malady

Rare diseases, Skin diseases categories
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Summaries for Seborrheic Keratosis

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A seborrheic keratosis (also known as \"seborrheic verruca,\" and \"senile wart\") is a noncancerous... more...

MalaCards: Seborrheic Keratosis, also known as keratosis seborrheica, is related to melanoma and adenocarcinoma. An important gene associated with Seborrheic Keratosis is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Endochondral Ossification and ATF-2 transcription factor network. The compounds p005 and cd 437 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and breast, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Description from OMIM:47 182000

Aliases & Classifications for Seborrheic Keratosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 58SNOMED-CT, 47OMIM, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

seborrheic keratosis 8 10 45 62
keratosis seborrheica 43
keratosis, seborrheic 43
seborrheic keratoses 43


Related Diseases for Seborrheic Keratosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Seborrheic Keratosis:



Diseases related to seborrheic keratosis

Symptoms for Seborrheic Keratosis

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47OMIM
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Clinical features from OMIM:

182000

Drugs & Therapeutics for Seborrheic Keratosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Seborrheic Keratosis

Search NIH Clinical Center for Seborrheic Keratosis

Genetic Tests for Seborrheic Keratosis

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Anatomical Context for Seborrheic Keratosis

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33MalaCards
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MalaCards organs/tissues related to Seborrheic Keratosis:

33
Skin, Liver, Breast, Colon, Myeloid, T cells

Animal Models for Seborrheic Keratosis or affiliated genes

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37MGI
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Publications for Seborrheic Keratosis

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52PubMed
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Articles related to Seborrheic Keratosis:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
Clonal seborrheic keratosis versus epidermal nevus. (23866887)
2013
2
Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. (23662587)
2013
3
Discrimination of squamous cell carcinoma in situ from seborrheic keratosis by color analysis techniques requires information from scale, scale-crust and surrounding areas in dermoscopy images. (23117020)
2012
4
Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (22236073)
2012
5
Bowenoid transformation in seborrheic keratosis: A retrospective analysis of 429 patients. (23267371)
2012
6
Seborrheic keratosis of the external auditory canal. (22090002)
2012
7
Coexistent Dowling-Degos disease and reticulate acropigmentation of kitamura with progressive seborrheic keratosis. (21416772)
2011
8
Seborrheic keratosis, keratotic type, of the external auditory canal. (21636843)
2011
9
Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. (21602158)
2011
10
Sebaceous carcinoma associated with seborrheic keratosis. (20868621)
2010
11
A case of irritated seborrheic keratosis associated with a previous incision site. (20532145)
2010
12
Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. (20425131)
2010
13
The vasculature of nonmelanocytic skin tumors in reflectance confocal microscopy, II: Vascular features of seborrheic keratosis. (20566947)
2010
14
Seborrheic keratosis or verruca plana? A pilot study with confocal laser scanning microscopy. (21039905)
2010
15
Melanoma in-situ arising in seborrheic keratosis: a case report. (18947402)
2008
16
Granular parakeratotic acanthoma is not adenoid seborrheic keratosis. (18496439)
2008
17
Giant genital seborrheic keratosis or Buschke LAPwenstein tumor? (18823349)
2008
18
Squamous eddies in irritated seborrheic keratosis. (17284959)
2007
19
Vulvar seborrheic keratosis. (18053380)
2007
20
Overexpression of p27KIP1 in seborrheic keratosis. (17942027)
2007
21
Pityrosporum and seborrheic keratosis: an association. (16150211)
2005
22
A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face. (15729860)
2004
23
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. (15128703)
2004
24
"Globulelike" dermoscopic structures in pigmented seborrheic keratosis. (14732676)
2004
25
Desmoplastic seborrheic keratosis. (12775983)
2003
26
Frequency of seborrheic keratosis biopsies in the United States: a benchmark of skin lesion care quality and cost effectiveness. (12859377)
2003
27
Dermoscopic diagnosis of seborrheic keratosis. (12074865)
2002
28
Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. (12472343)
2002
29
Sebaceoma arising in association with seborrheic keratosis. (11176054)
2001
30
Compare your diagnosis. Xanthogranuloma, seborrheic keratosis associated with mycosis fungoides, Kikuchi's disease. (10027533)
1999
31
A case of seborrheic keratosis distributed along skin cleavage lines. (9609989)
1998
32
Malignancy arising in seborrheic keratosis: a report of two cases. (9208082)
1997
33
Malignant melanoma simulating a seborrheic keratosis: a case report. (9141366)
1997
34
Globulelike dermoscopic structures in pigmented seborrheic keratosis. (9126023)
1997
35
Dermacase. Seborrheic keratosis. (8081119)
1994
36
Clinical misdiagnosis of melanoma as well as squamous cell carcinoma masquerading as seborrheic keratosis. (8151040)
1994
37
Seborrheic keratosis with trichilemmomas masquerading as melanoma. (7835066)
1994
38
Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction. (1337468)
1992
39
Acantholytic variant of seborrheic keratosis. (2138642)
1990
40
Seborrheic keratosis with focal acantholysis. (2470800)
1989
41
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
42
Multiple small papular seborrheic keratosis. (2976363)
1988
43
Seborrheic keratosis? (3965523)
1985
44
Differentiating seborrheic keratosis from skin neoplasm. (4007500)
1985
45
Malignant melanoma appearing in seborrheic keratosis. (6232304)
1984
46
Seborrheic keratosis and papillomatosis: markers of breast adenocarcinoma. (6225626)
1983
47
Squamous cell carcinoma arising in seborrheic keratosis. (6970889)
1981
48
A tridimensional view of seborrheic keratosis. (6447911)
1980
49
Treatment of seborrheic keratosis. (4247377)
1970
50
Seborrheic keratosis and verruca, with special reference to the melanotic variety. (14810197)
1951

Variations for Seborrheic Keratosis

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Expression for genes affiliated with Seborrheic Keratosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seborrheic Keratosis

Search GEO for disease gene expression data for Seborrheic Keratosis.

Pathways for genes affiliated with Seborrheic Keratosis

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50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 55Reactome, 30KEGG
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Compounds for genes affiliated with Seborrheic Keratosis

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45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1p005459.9TP63, TGFB2
2cd 437459.8NR1H2, BCL2
3noxa459.8BCL2, TP63
4n-(4-hydroxyphenyl)retinamide459.5NR1H2, BCL2
5tamoxifen45 51 29 1112.5NR1H2, BCL2, TGFB2
6mptp459.4BCL2, TGFB2
7genistein45 29 61 3 24 1114.3NR1H2, BCL2, TGFB2
8doxorubicin45 51 1111.3TP63, BCL2, FGFR3
9paraffin459.3FGFR3, BCL2, TGFB2, TP63
10dexamethasone45 51 29 1112.3TGFB2, BCL2, NR1H2, FGFR3
11glutamate459.3TP63, TGFB2, NR1H2, FGFR3
12progesterone45 29 61 24 1113.2TP63, TGFB2, BCL2, NR1H2
13steroid459.1KLK8, NR1H2, TGFB2, TP63
14estrogen459.0NR1H2, BCL2, TGFB2, TP63
15vegf458.6FGFR3, NR1H2, BCL2, POU5F1, TGFB2, TP63
16retinoic acid45 249.6TP63, TGFB2, POU5F1, DSG1, BCL2, NR1H2
17serine458.5TGFB2, DSG1, BCL2, NR1H2, KLK8, FGFR3

GO Terms for genes affiliated with Seborrheic Keratosis

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16Gene Ontology
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Cellular components related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.8FGFR3, DSG1
2chromatinGO:0007859.5MAGED1, TP63
3nucleoplasmGO:0056548.4NR1H2, MED10, POU5F1, TP63

Biological processes related to Seborrheic Keratosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1digestive tract morphogenesisGO:04854610.0FGFR3, BCL2
2response to progesteroneGO:03257010.0TGFB2, DSG1
3somatic stem cell maintenanceGO:0350199.8FGFR3, POU5F1
4cell agingGO:0075699.8TP63, BCL2
5keratinocyte proliferationGO:0436169.8TP63, KLK8
6response to gamma radiationGO:0103329.8BCL2, TP63
7positive regulation of neuron apoptotic processGO:0435259.8TGFB2, FGFR3
8positive regulation of cell growthGO:0303079.7BCL2, TGFB2
9positive regulation of apoptotic signaling pathwayGO:20012359.7MAGED1, TP63
10neuron apoptotic processGO:0514029.7BCL2, TP63
11negative regulation of epithelial cell proliferationGO:0506809.7TGFB2, MAGED1, FGFR3
12hair follicle morphogenesisGO:0310699.6BCL2, TGFB2, TP63
13response to woundingGO:0096119.6KLK8, POU5F1, TGFB2
14cell deathGO:0082199.5TGFB2, BCL2, KLK8
15cell growthGO:0160499.4BCL2, TGFB2
16apoptotic processGO:0069159.0BCL2, MAGED1, DSG1, TP63
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.9TP63, POU5F1, MED10, NR1H2

Molecular functions related to Seborrheic Keratosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435658.6TP63, POU5F1, BCL2, NR1H2
2protein bindingGO:0055157.3TP63, TGFB2, POU5F1, MAGED1, BCL2, NR1H2

Products for genes affiliated with Seborrheic Keratosis

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Sources for Seborrheic Keratosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet