MCID: SCN052
MIFTS: 37

Secondary Adrenal Insufficiency

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Secondary Adrenal Insufficiency

MalaCards integrated aliases for Secondary Adrenal Insufficiency:

Name: Secondary Adrenal Insufficiency 50 69
Hypocortisolism Secondary to Another Disorder 69

Classifications:



Summaries for Secondary Adrenal Insufficiency

NIH Rare Diseases : 50 adrenal insufficiency is an endocrine disorder that occurs when the adrenal glands do not produce enough of certain hormones. secondary adrenal insufficiency occurs when the pituitary gland (a pea-sized gland at the base of the brain) fails to produce enough adrenocorticotropin (acth), a hormone that stimulates the adrenal glands to produce the hormone cortisol. the lack of these hormones in the body can be caused by reduction or cessation of corticosteroid medication, the surgical removal of pituitary tumors, or changes in the pituitary gland. symptoms of secondary adrenal insufficiency may include severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression. treatment includes replacing the hormones that the adrenal glands are not making. the dose of each medication is adjusted to meet the needs of each affected individual. last updated: 8/25/2015

MalaCards based summary : Secondary Adrenal Insufficiency, also known as hypocortisolism secondary to another disorder, is related to immune system organ benign neoplasm and molybdenum cofactor deficiency b. An important gene associated with Secondary Adrenal Insufficiency is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Adipogenesis. The drugs Etomidate and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and adrenal gland, and related phenotype is renal/urinary system.

Related Diseases for Secondary Adrenal Insufficiency

Diseases in the Acute Adrenal Insufficiency family:

Secondary Adrenal Insufficiency

Diseases related to Secondary Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 immune system organ benign neoplasm 10.3 AVP IGF1
2 molybdenum cofactor deficiency b 10.3 AVP IGF1
3 small cell lung cancer, childhood 10.2 IGF1 IGFBP3
4 lipase deficiency, combined 10.2 IGF1 IGFBP3
5 pulmonary large cell neuroendocrine carcinoma 10.2 IGF1 IGFBP3
6 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.2 IGF1 IGFBP3
7 growth hormone insensitivity, partial 10.1 IGF1 IGFBP3
8 pituitary adenoma, prolactin-secreting 10.1 IGF1 IGFBP3
9 phacolytic glaucoma 10.1 IGF1 IGFBP3
10 caffey disease 10.1 IGF1 IGFBP3
11 grubben de cock borghgraef syndrome 10.1 IGF1 IGFBP3
12 congenital hypomyelination neuropathy 10.1 IGF1 IGFBP3
13 albinism, oculocutaneous, type ia 10.1 IGF1 IGFBP3
14 medullomyoblastoma 10.1 IGF1 IGFBP3
15 bile duct signet ring cell carcinoma 10.0 IGF1 IGFBP3
16 plague 10.0 IGF1 IGFBP3
17 diencephalic neoplasm 10.0 AVP INS
18 ulcerative blepharitis 9.9 IGF1 INS
19 hypertensive encephalopathy 9.9 AVP INS
20 tinf2-related dyskeratosis congenita 9.9 IGF1 INS
21 bardet-biedl syndrome 9.9 IGF1 IGFBP3
22 algoneurodystrophy 9.9 IGF1 INS
23 neurogenic arthropathy 9.9 IGF1 INS
24 porokeratosis 9.9 IGF1 INS
25 aromatic l-amino acid decarboxylase deficiency 9.9 IGF1 IGFBP3
26 fibrolamellar carcinoma 9.9 IGF1 INS
27 capillary lymphangioma 9.9 IGF1 INS
28 adamantinous craniopharyngioma 9.9 IGF1 INS
29 vernal conjunctivitis 9.9 IGF1 INS
30 pelvic muscle wasting 9.9 IGF1 INS
31 male reproductive organ benign neoplasm 9.9 IGF1 INS
32 deafness, autosomal dominant 6/14/38 9.9 AVP INS
33 cardiomyopathy 9.9
34 diabetic encephalopathy 9.8 IGF1 INS
35 periampullary adenoma 9.8 IGF1 INS
36 citrullinemia, adult-onset type ii 9.8 IGF1 INS
37 calcinosis 9.8 AVP INS
38 inherited metabolic disorder 9.8 IGF1 INS
39 spinal cord injury 9.8
40 hypertrichosis 9.8 IGF1 INS
41 leopard syndrome 1 9.7 IGF1 IGFBP3
42 survival motor neuron spinal muscular atrophy 9.7 IGF1 INS
43 short bowel syndrome 9.6 IGF1 INS
44 renal cell carcinoma 9.6
45 pituitary adenoma 9.6
46 insulin-like growth factor i 9.6
47 stiff-person syndrome 9.6
48 esophagitis 9.6
49 cushing's syndrome 9.6
50 hypothyroidism 9.6

Graphical network of the top 20 diseases related to Secondary Adrenal Insufficiency:



Diseases related to Secondary Adrenal Insufficiency

Symptoms & Phenotypes for Secondary Adrenal Insufficiency

MGI Mouse Phenotypes related to Secondary Adrenal Insufficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 AVP IGF1 INS

Drugs & Therapeutics for Secondary Adrenal Insufficiency

Drugs for Secondary Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-23-7 5754 657311
7 Racepinephrine Approved Phase 4,Phase 2,Phase 3
8
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
9
Cortisone acetate Approved Phase 4 1950-04-4, 50-04-4 5745
10
Budesonide Approved Phase 4 51333-22-3 63006 5281004
11
Menthol Approved Phase 4 2216-51-5 16666
12
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
13
Xylometazoline Approved Phase 4 526-36-3 5709
14
Desoximetasone Approved Phase 4,Phase 2 382-67-2 5311067
15
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17 Cisatracurium Experimental Phase 4 96946-41-7
18
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
19
Clobetasol Investigational Phase 4,Phase 2 25122-46-7, 25122-41-2 32798 5311051
20 Adjuvants, Anesthesia Phase 4
21 Analgesics Phase 4
22 Analgesics, Opioid Phase 4
23 Anesthetics Phase 4
24 Anesthetics, General Phase 4
25 Anesthetics, Intravenous Phase 4
26
Atracurium Phase 4 64228-79-1 47319
27 Central Nervous System Depressants Phase 4
28 Cholinergic Agents Phase 4
29 Cholinergic Antagonists Phase 4
30 Hypnotics and Sedatives Phase 4
31 Narcotics Phase 4
32 Neuromuscular Agents Phase 4
33 Neuromuscular Blocking Agents Phase 4
34 Neuromuscular Nondepolarizing Agents Phase 4
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
37 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
38 Cortisol succinate Phase 4,Phase 2,Phase 3
39 Epinephryl borate Phase 4,Phase 2,Phase 3
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3
45 Hydrocortisone acetate Phase 4,Phase 2,Phase 3
46 Adrenergic Agents Phase 4,Phase 3,Phase 2
47 Adrenergic Agonists Phase 4,Phase 3,Phase 2
48 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
49 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
50 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 62)

id Name Status NCT ID Phase Drugs
1 THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients Unknown status NCT02111265 Phase 4 Remifentanil;Cisatracurium;Sufentanil
2 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
3 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
4 Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma Completed NCT00238927 Phase 4 inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
5 Effect on Adrenal Function of Budesonide Versus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01186653 Phase 4 budesonide / formoterol;fluticasone/salmeterol
6 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
7 Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05% Recruiting NCT03212963 Phase 4 Halobetasol Topical Lotion
8 Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis Recruiting NCT02340169 Phase 4 Topicort® (desoximetasone) Topical Spray, 0.25%
9 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
10 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
11 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
12 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
13 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
14 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
15 Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer Completed NCT00060398 Phase 3 dexamethasone
16 Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis Completed NCT01232543 Phase 2 Product 0405
17 Pharmacokinetics of 122-0551 and Its Effects on Adrenal Suppression Completed NCT01698333 Phase 2 122-0551
18 HPA Axis Study in Japanese Adults Completed NCT01407510 Phase 2 Mapracorat
19 HPA Axis Study in Adults Completed NCT01408511 Phase 2 Mapracorat
20 An Evaluation of the Adrenal Suppression Potential and Pharmacokinetic Properties of CB-03-01 Cream in Subjects With Acne Vulgaris Completed NCT01831960 Phase 2 cortexolone 17α-propionate
21 Desoximetasone Spray 0.25%, Hypothalamic Pituitary Adrenal (HPA) Axis Study Completed NCT01043393 Phase 2 Desoximetasone 0.25% spray
22 DFD06 Cream vs Comp01 Cream HPA Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis Completed NCT02131324 Phase 2 DFD06 Cream;Comp01
23 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
24 Blinded Study of Topical Investigational Lotion Vs. Approved Cream in Treatment of Plaque Psoriasis Completed NCT01166646 Phase 2 Halobetasol Proprionate Lotion 0.05%;Halobetasol Proprionate Cream 0.05%
25 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
26 Vaginal Prednisone Administration for Prevention of Adrenal Crisis Completed NCT02689960 Phase 2 100mg prednisone suppository
27 Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia Completed NCT01859312 Phase 2 Hydrocortisone (Solucortef)
28 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression. Recruiting NCT02932891 Phase 2 DSXS topical
29 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression Recruiting NCT02932878 Phase 2 DSXS topical
30 Safety Study to Assess the Potential for Adrenal Suppression Following Maximal Use Treatment With DSXS Recruiting NCT02933528 Phase 2 DSXS Topical product
31 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Plaque Psoriasis Recruiting NCT02601469 Phase 2 DSXS
32 An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris Recruiting NCT02720627 Phase 2 cortexolone 17α-propionate
33 Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Recruiting NCT03179605 Phase 2 DFD06
34 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Atopic Dermatitis Recruiting NCT02595008 Phase 2 DSXS
35 Safety Study in Patients With Scalp Psoriasis Suppression Following Maximal Use Treatment With Topical Product Recruiting NCT02933502 Phase 2 DSXS topical product
36 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Atopic Dermatitis Active, not recruiting NCT03245385 Phase 2 Treatment with Halobetasol propionate 0.05% topical spray
37 Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Plaque Psoriasis Not yet recruiting NCT03298581 Phase 2 Halobetasol Propionate
38 Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers Completed NCT00936793 Phase 1 Darunavir;Ritonavir;Beclomethasone Dipropionate HFA
39 Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Unknown status NCT02368379
40 Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections Unknown status NCT01717430
41 Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy Completed NCT01209507
42 Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate Completed NCT00575029 megestrol acetate
43 Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis Completed NCT01799408
44 Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function Completed NCT00561236
45 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
46 Survey in Patients With Chronic Adrenal Insufficiency in Germany Completed NCT00444119
47 THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone Completed NCT03013166
48 Biomarker(s) for Glucocorticoids Completed NCT02152553 Hydrocortisone;Placebo
49 Value of 25 mcg Cortrosyn Stimulation Test Completed NCT01428336
50 Adrenal Function in Patients With Newly Diagnosed Lung Cancer Completed NCT00364624

Search NIH Clinical Center for Secondary Adrenal Insufficiency

Genetic Tests for Secondary Adrenal Insufficiency

Anatomical Context for Secondary Adrenal Insufficiency

MalaCards organs/tissues related to Secondary Adrenal Insufficiency:

39
Pituitary, Brain, Adrenal Gland, Testes, Lung, Kidney, Thyroid

Publications for Secondary Adrenal Insufficiency

Articles related to Secondary Adrenal Insufficiency:

(show top 50) (show all 51)
id Title Authors Year
1
A case of stiff-person syndrome due to secondary adrenal insufficiency. ( 28552871 )
2017
2
Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab. ( 28945828 )
2017
3
Somatosensory function in patients with secondary adrenal insufficiency treated with two different doses of hydrocortisone-Results from a randomized controlled trial. ( 28686664 )
2017
4
Primary Hypothyroid and Secondary Adrenal Insufficiency-Searching the Missing Link. ( 28571201 )
2017
5
Gastric cancer with pituitary metastasis presenting as symptomatic secondary adrenal insufficiency: A case report. ( 28421712 )
2017
6
National German Audit of Diagnosis, Treatment, and Teaching in Secondary Adrenal Insufficiency. ( 28351092 )
2017
7
Secondary adrenal insufficiency: from the physiopathology to the possible role of modified-release hydrocortisone treatment. ( 28750490 )
2017
8
Secondary Adrenal Insufficiency Following Nivolumab Therapy in a Patient with Metastatic Renal Cell Carcinoma. ( 28871578 )
2017
9
Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism. ( 26928716 )
2016
10
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. ( 27516913 )
2016
11
Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. ( 27355580 )
2016
12
Large-Dose Glucocorticoid Induced Secondary Adrenal Insufficiency in Spinal Cord Injury. ( 28119833 )
2016
13
"Petrified Ears" in Secondary Adrenal Insufficiency. ( 27042511 )
2016
14
Recovery of Adrenal Function in Patients with Glucocorticoids Induced Secondary Adrenal Insufficiency. ( 26676337 )
2016
15
Reversible Cardiomyopathy Accompanied by Secondary Adrenal Insufficiency. ( 26920218 )
2016
16
Secondary Adrenal Insufficiency: Where Is It Hidden and What Does It Look Like? ( 27211575 )
2016
17
Esophageal eosinophilia in secondary adrenal insufficiency. ( 27186162 )
2016
18
Acute psychosis in the course of treatment of acute adrenal crisis with hydrocortisone in the patient with secondary adrenal insufficiency - a case study. ( 26488344 )
2015
19
Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary and secondary adrenal insufficiency. ( 25656494 )
2015
20
Secondary adrenal insufficiency: an overlooked cause of hyponatremia. ( 25699130 )
2015
21
Takotsubo cardiomyopathy in a patient with pituitary adenoma and secondary adrenal insufficiency. ( 26816449 )
2015
22
The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial. ( 25705800 )
2015
23
Concomitant giant cell arteritis and secondary adrenal insufficiency. ( 26169623 )
2015
24
Primary vs secondary adrenal insufficiency: ACTH-stimulated aldosterone diagnostic cut-off values by tandem mass spectrometry. ( 25620457 )
2015
25
Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. ( 26161260 )
2015
26
Hyponatremia due to Secondary Adrenal Insufficiency Successfully Treated by Dexamethasone with Sodium Chloride. ( 26319655 )
2015
27
Phosphoglucomutase-1 deficiency: Intrafamilial clinical variability and common secondary adrenal insufficiency. ( 26768186 )
2015
28
A Case of Primary and Secondary Adrenal Insufficiency in Children. ( 26092585 )
2015
29
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 23778239 )
2014
30
Secondary adrenal insufficiency after glucocorticosteroid administration in acute spinal cord injury: a case report. ( 24969098 )
2014
31
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 25513635 )
2014
32
Health-related quality of life in primary and secondary adrenal insufficiency. ( 25252879 )
2014
33
Flexion contractures of the legs as the manifestation of secondary adrenal insufficiency due to Sheehan's syndrome. ( 22996815 )
2014
34
Inhaled corticosteroids and secondary adrenal insufficiency. ( 25674179 )
2014
35
Acute secondary adrenal insufficiency as the presenting manifestation of small-cell lung carcinoma. ( 24532238 )
2014
36
Topical corticosteroids and secondary adrenal insufficiency: a relationship in the shade. ( 24076040 )
2013
37
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
38
Effects of standard glucocorticoid replacement therapies on subjective well-being: a randomized, double-blind, crossover study in patients with secondary adrenal insufficiency. ( 22930487 )
2012
39
Assessment of glucocorticoid therapy with salivary cortisol in secondary adrenal insufficiency. ( 23034783 )
2012
40
Malakoplakia of the kidney extending to the descending colon in a patient with secondary adrenal insufficiency: a case report. ( 22745875 )
2011
41
Autoimmune hyperthyroidism due to secondary adrenal insufficiency: resolution with glucocorticoids. ( 20841313 )
2011
42
Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. ( 20456080 )
2010
43
Flexion contractures in secondary adrenal insufficiency. ( 19795178 )
2010
44
Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial. ( 19318448 )
2009
45
[Secondary adrenal insufficiency after local injections of triamcinolone acetonide]. ( 19197811 )
2009
46
Diagnosis of secondary adrenal insufficiency: unstimulated early morning cortisol in saliva and serum in comparison with the insulin tolerance test. ( 19585406 )
2009
47
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. ( 18827959 )
2008
48
Ampulla (Takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency. ( 17664847 )
2007
49
Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial. ( 15797966 )
2005
50
Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency. ( 12590641 )
2003

Variations for Secondary Adrenal Insufficiency

Expression for Secondary Adrenal Insufficiency

Search GEO for disease gene expression data for Secondary Adrenal Insufficiency.

Pathways for Secondary Adrenal Insufficiency

GO Terms for Secondary Adrenal Insufficiency

Cellular components related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP IGF1 IGFBP3 INS
2 extracellular region GO:0005576 9.55 AVP IGF1 IGFBP3 INS PGM1
3 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
4 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 AVP IGF1 INS
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IGF1 INS
3 positive regulation of cell growth GO:0030307 9.55 AVP INS
4 cellular protein metabolic process GO:0044267 9.54 IGF1 IGFBP3 INS
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.52 IGF1 INS
6 glucose metabolic process GO:0006006 9.51 INS PGM1
7 positive regulation of DNA replication GO:0045740 9.49 IGF1 INS
8 positive regulation of glucose import GO:0046326 9.48 IGF1 INS
9 activation of protein kinase B activity GO:0032148 9.46 IGF1 INS
10 ERK1 and ERK2 cascade GO:0070371 9.43 AVP IGF1
11 positive regulation of mitotic nuclear division GO:0045840 9.4 IGF1 INS
12 positive regulation of glycolytic process GO:0045821 9.32 IGF1 INS
13 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.26 AVP IGF1
14 positive regulation of glycogen biosynthetic process GO:0045725 9.16 IGF1 INS
15 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 IGF1 IGFBP3
16 positive regulation of MAPK cascade GO:0043410 8.8 IGF1 IGFBP3 INS

Molecular functions related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 IGF1 INS
2 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS
3 hormone activity GO:0005179 8.8 AVP IGF1 INS

Sources for Secondary Adrenal Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....