MCID: SCN052
MIFTS: 37

Secondary Adrenal Insufficiency malady

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Secondary Adrenal Insufficiency

Aliases & Descriptions for Secondary Adrenal Insufficiency:

Name: Secondary Adrenal Insufficiency 50 69
Hypocortisolism Secondary to Another Disorder 69

Classifications:



Summaries for Secondary Adrenal Insufficiency

NIH Rare Diseases : 50 adrenal insufficiency is an endocrine disorder that occurs when the adrenal glands do not produce enough of certain hormones. secondary adrenal insufficiency occurs when the pituitary gland (a pea-sized gland at the base of the brain) fails to produce enough adrenocorticotropin (acth), a hormone that stimulates the adrenal glands to produce the hormone cortisol. the lack of these hormones in the body can be caused by reduction or cessation of corticosteroid medication, the surgical removal of pituitary tumors, or changes in the pituitary gland. symptoms of secondary adrenal insufficiency may include severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression. treatment includes replacing the hormones that the adrenal glands are not making. the dose of each medication is adjusted to meet the needs of each affected individual. last updated: 8/25/2015

MalaCards based summary : Secondary Adrenal Insufficiency, also known as hypocortisolism secondary to another disorder, is related to bone benign neoplasm and mucopolysaccharidosis type vi. An important gene associated with Secondary Adrenal Insufficiency is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Adipogenesis. The drugs Epinephrine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and brain.

Related Diseases for Secondary Adrenal Insufficiency

Diseases in the Acute Adrenal Insufficiency family:

Congenital Adrenal Insufficiency Secondary Adrenal Insufficiency

Diseases related to Secondary Adrenal Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 bone benign neoplasm 10.1 AVP IGF1
2 mucopolysaccharidosis type vi 10.1 AVP IGF1
3 sohval soffer syndrome 10.1 IGF1 IGFBP3
4 microtia, hearing impairment, and cleft palate 10.1 IGF1 IGFBP3
5 spondylometaphyseal dysplasia, megarbane-dagher-melike type 10.1 IGF1 IGFBP3
6 capgras syndrome 10.1 IGF1 IGFBP3
7 pituitary adenoma, acth-secreting 10.1 IGF1 IGFBP3
8 epileptic encephalopathy, early infantile, 24 10.1 IGF1 IGFBP3
9 phacolytic glaucoma 10.1 IGF1 IGFBP3
10 mental retardation, autosomal recessive 35 10.1 IGF1 IGFBP3
11 gynandroblastoma 10.1 IGF1 IGFBP3
12 post-traumatic stress disorder 10.1 IGF1 IGFBP3
13 ehlers-danlos syndrome, cardiac valvular form 10.1 IGF1 IGFBP3
14 congenital symblepharon 10.0 IGF1 IGFBP3
15 central nervous system leiomyoma 10.0 IGF1 IGFBP3
16 albinism, oculocutaneous, type ib 10.0 IGF1 IGFBP3
17 argininosuccinic aciduria 10.0 IGF1 IGFBP3
18 extrahepatic bile duct adenocarcinoma 10.0 IGF1 IGFBP3
19 diencephalic neoplasm 10.0 AVP INS
20 fatty liver disease 10.0 AVP INS
21 dacryoadenitis 10.0 IGF1 INS
22 necrobiosis lipoidica 10.0 IGF1 IGFBP3
23 tmem231-related joubert syndrome 10.0 IGF1 INS
24 brucella canis brucellosis 10.0 IGF1 INS
25 adult medulloblastoma 10.0 IGF1 IGFBP3
26 epidural spinal canal meningioma 10.0 IGF1 INS
27 neurogenic arthropathy 10.0 IGF1 INS
28 pelvic muscle wasting 10.0 IGF1 INS
29 papillary craniopharyngioma 10.0 IGF1 INS
30 aflatoxins-related hepatocellular carcinoma 10.0 IGF1 INS
31 capillary lymphangioma 10.0 IGF1 INS
32 vernal conjunctivitis 10.0 IGF1 INS
33 limb ischemia 10.0 IGF1 INS
34 diabetic encephalopathy 10.0 IGF1 INS
35 citrullinemia, type ii, neonatal-onset 9.9 IGF1 INS
36 vestibular gland benign neoplasm 9.9 IGF1 INS
37 metachondromatosis 9.9 IGF1 IGFBP3
38 calcinosis 9.9 AVP INS
39 pinguecula 9.9 IGF1 INS
40 adrenal adenoma 9.9 IGF1 INS
41 cardiomyopathy 9.9
42 peroneal neuropathy 9.8 IGF1 INS
43 urethra clear cell adenocarcinoma 9.8 AVP IGF1 INS
44 chondroma 9.8 AVP IGF1 INS
45 blind loop syndrome 9.8 IGF1 INS
46 bardet-biedl syndrome 9.8 IGF1 IGFBP3
47 diarrhea 3, secretory sodium, congenital, syndromic 9.8 IGF1 IGFBP3 INS
48 hyperinsulinemic hypoglycemia, familial, 5 9.8 IGF1 IGFBP3 INS
49 protein s deficiency 9.8 IGF1 IGFBP3 INS
50 gerstmann syndrome 9.8 IGF1 IGFBP3 INS

Graphical network of the top 20 diseases related to Secondary Adrenal Insufficiency:



Diseases related to Secondary Adrenal Insufficiency

Symptoms & Phenotypes for Secondary Adrenal Insufficiency

Drugs & Therapeutics for Secondary Adrenal Insufficiency

Drugs for Secondary Adrenal Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 172)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Cortisone acetate Approved Phase 4 1950-04-4, 50-04-4 5745
6
Etomidate Approved Phase 4 33125-97-2 36339 667484
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10
Budesonide Approved Phase 4 51333-22-3 63006 5281004
11
Fludrocortisone Approved Phase 4,Phase 3,Phase 2 127-31-1 31378
12
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
13
Menthol Approved Phase 4 2216-51-5 16666
14
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
15
Desoximetasone Approved Phase 4,Phase 2 382-67-2 5311067
16
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
17
Xylometazoline Approved Phase 4 526-36-3 5709
18 tannic acid Approved, Nutraceutical Phase 4,Phase 3
19
Butyric Acid Experimental Phase 4,Phase 3,Phase 2 107-92-6 264
20
Cortisone Phase 4 53-06-5 222786
21
Atracurium Phase 4 64228-79-1 47319
22 Cisatracurium Phase 4
23 Analgesics Phase 4
24 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
25 Cholinergic Agents Phase 4
26 Adjuvants, Anesthesia Phase 4
27 Mydriatics Phase 4,Phase 3,Phase 2
28 Cholinergic Antagonists Phase 4
29 Adrenergic Agents Phase 4,Phase 3,Phase 2
30 Narcotics Phase 4
31 Adrenergic Agonists Phase 4,Phase 3,Phase 2
32 Neuromuscular Agents Phase 4
33 Neuromuscular Blocking Agents Phase 4
34 Neuromuscular Nondepolarizing Agents Phase 4
35 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
36 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
38 Cortisol succinate Phase 4,Phase 3,Phase 2
39 Analgesics, Opioid Phase 4
40 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Anesthetics Phase 4,Phase 2,Phase 3
42 Hormones Phase 4,Phase 3,Phase 2,Phase 1
43 Anesthetics, General Phase 4
44 Anesthetics, Intravenous Phase 4
45 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
47 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
48 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 3,Phase 2
49 Hydrocortisone acetate Phase 4,Phase 3,Phase 2
50 Epinephryl borate Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 72)
id Name Status NCT ID Phase
1 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Unknown status NCT02277587 Phase 4
2 THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients Unknown status NCT02111265 Phase 4
3 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4
4 Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma Completed NCT00238927 Phase 4
5 Effect on Adrenal Function of Budesonide Versus Fluticasone in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01186653 Phase 4
6 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4
7 Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis Recruiting NCT02340169 Phase 4
8 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4
9 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Active, not recruiting NCT02206256 Phase 4
10 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4
11 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4
12 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4
13 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4
14 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3
15 Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer Completed NCT00060398 Phase 3
16 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3
17 COrticosteroid in Congenital Adrenal Hyperplasia Recruiting NCT02552251 Phase 2, Phase 3
18 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
19 Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis Completed NCT01232543 Phase 2
20 Pharmacokinetics of 122-0551 and Its Effects on Adrenal Suppression Completed NCT01698333 Phase 2
21 HPA Axis Study in Japanese Adults Completed NCT01407510 Phase 2
22 HPA Axis Study in Adults Completed NCT01408511 Phase 2
23 An Evaluation of the Adrenal Suppression Potential and Pharmacokinetic Properties of CB-03-01 Cream in Subjects With Acne Vulgaris Completed NCT01831960 Phase 2
24 Desoximetasone Spray 0.25%, Hypothalamic Pituitary Adrenal (HPA) Axis Study Completed NCT01043393 Phase 2
25 DFD06 Cream vs Comp01 Cream HPA Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis Completed NCT02131324 Phase 2
26 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2
27 Blinded Study of Topical Investigational Lotion Vs. Approved Cream in Treatment of Plaque Psoriasis Completed NCT01166646 Phase 2
28 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2
29 Vaginal Prednisone Administration for Prevention of Adrenal Crisis Completed NCT02689960 Phase 2
30 Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia Completed NCT01859312 Phase 2
31 Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea Completed NCT00503802 Phase 2
32 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression. Recruiting NCT02932891 Phase 2
33 An Open Label, Safety Study to Assess the Potential for Adrenal Suppression Recruiting NCT02932878 Phase 2
34 Safety Study to Assess the Potential for Adrenal Suppression Following Maximal Use Treatment With DSXS Recruiting NCT02933528 Phase 2
35 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Plaque Psoriasis Recruiting NCT02601469 Phase 2
36 An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris Recruiting NCT02720627 Phase 2
37 Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 Recruiting NCT03179605 Phase 2
38 Study to Assess the Potential for Adrenal Suppression Following Treatment With DSXS in Patients With Atopic Dermatitis Recruiting NCT02595008 Phase 2
39 Safety Study in Patients With Scalp Psoriasis Suppression Following Maximal Use Treatment With Topical Product Recruiting NCT02933502 Phase 2
40 Autologous Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy and Adrenoleukodystrophy Recruiting NCT02559830 Phase 1, Phase 2
41 Impact of the Administration of Fludrocortisone in Very Premature Infants Not yet recruiting NCT03001089 Phase 2
42 Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers Completed NCT00936793 Phase 1
43 UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells Recruiting NCT02254863 Phase 1
44 Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Unknown status NCT02368379
45 Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections Unknown status NCT01717430
46 Local Anaesthesia vs Regional Block for Arteriovenous Fistulae Unknown status NCT01706354
47 Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy Completed NCT01209507
48 Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate Completed NCT00575029
49 Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis Completed NCT01799408
50 Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function Completed NCT00561236

Search NIH Clinical Center for Secondary Adrenal Insufficiency

Genetic Tests for Secondary Adrenal Insufficiency

Anatomical Context for Secondary Adrenal Insufficiency

MalaCards organs/tissues related to Secondary Adrenal Insufficiency:

39
Pituitary, Adrenal Gland, Brain, Testes, Kidney, Spinal Cord, Colon

Publications for Secondary Adrenal Insufficiency

Articles related to Secondary Adrenal Insufficiency:

(show all 42)
id Title Authors Year
1
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. ( 27516913 )
2016
2
Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism. ( 26928716 )
2016
3
Esophageal eosinophilia in secondary adrenal insufficiency. ( 27186162 )
2016
4
Reversible Cardiomyopathy Accompanied by Secondary Adrenal Insufficiency. ( 26920218 )
2016
5
Recovery of Adrenal Function in Patients with Glucocorticoids Induced Secondary Adrenal Insufficiency. ( 26676337 )
2016
6
Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. ( 27355580 )
2016
7
"Petrified Ears" in Secondary Adrenal Insufficiency. ( 27042511 )
2016
8
Secondary Adrenal Insufficiency: Where Is It Hidden and What Does It Look Like? ( 27211575 )
2016
9
Takotsubo cardiomyopathy in a patient with pituitary adenoma and secondary adrenal insufficiency. ( 26816449 )
2015
10
Phosphoglucomutase-1 deficiency: Intrafamilial clinical variability and common secondary adrenal insufficiency. ( 26768186 )
2015
11
Acute psychosis in the course of treatment of acute adrenal crisis with hydrocortisone in the patient with secondary adrenal insufficiency - a case study. ( 26488344 )
2015
12
Primary vs secondary adrenal insufficiency: ACTH-stimulated aldosterone diagnostic cut-off values by tandem mass spectrometry. ( 25620457 )
2015
13
A Case of Primary and Secondary Adrenal Insufficiency in Children. ( 26092585 )
2015
14
Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary and secondary adrenal insufficiency. ( 25656494 )
2015
15
Concomitant giant cell arteritis and secondary adrenal insufficiency. ( 26169623 )
2015
16
Secondary adrenal insufficiency: an overlooked cause of hyponatremia. ( 25699130 )
2015
17
The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial. ( 25705800 )
2015
18
Hyponatremia due to Secondary Adrenal Insufficiency Successfully Treated by Dexamethasone with Sodium Chloride. ( 26319655 )
2015
19
Opioid-induced secondary adrenal insufficiency presenting as hypercalcaemia. ( 26161260 )
2015
20
Acute secondary adrenal insufficiency as the presenting manifestation of small-cell lung carcinoma. ( 24532238 )
2014
21
Secondary adrenal insufficiency after glucocorticosteroid administration in acute spinal cord injury: a case report. ( 24969098 )
2014
22
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 25513635 )
2014
23
Inhaled corticosteroids and secondary adrenal insufficiency. ( 25674179 )
2014
24
Iatrogenic Cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review. ( 23778239 )
2014
25
Health-related quality of life in primary and secondary adrenal insufficiency. ( 25252879 )
2014
26
Flexion contractures of the legs as the manifestation of secondary adrenal insufficiency due to Sheehan's syndrome. ( 22996815 )
2014
27
Topical corticosteroids and secondary adrenal insufficiency: a relationship in the shade. ( 24076040 )
2013
28
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
29
Effects of standard glucocorticoid replacement therapies on subjective well-being: a randomized, double-blind, crossover study in patients with secondary adrenal insufficiency. ( 22930487 )
2012
30
Assessment of glucocorticoid therapy with salivary cortisol in secondary adrenal insufficiency. ( 23034783 )
2012
31
Autoimmune hyperthyroidism due to secondary adrenal insufficiency: resolution with glucocorticoids. ( 20841313 )
2011
32
Malakoplakia of the kidney extending to the descending colon in a patient with secondary adrenal insufficiency: a case report. ( 22745875 )
2011
33
Flexion contractures in secondary adrenal insufficiency. ( 19795178 )
2010
34
Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. ( 20456080 )
2010
35
Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial. ( 19318448 )
2009
36
Diagnosis of secondary adrenal insufficiency: unstimulated early morning cortisol in saliva and serum in comparison with the insulin tolerance test. ( 19585406 )
2009
37
[Secondary adrenal insufficiency after local injections of triamcinolone acetonide]. ( 19197811 )
2009
38
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. ( 18827959 )
2008
39
Ampulla (Takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency. ( 17664847 )
2007
40
Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial. ( 15797966 )
2005
41
Mood disorder and secondary adrenal insufficiency after pituitary tumor operation and radiotherapy. ( 12889508 )
2003
42
Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency. ( 12590641 )
2003

Variations for Secondary Adrenal Insufficiency

Expression for Secondary Adrenal Insufficiency

Search GEO for disease gene expression data for Secondary Adrenal Insufficiency.

Pathways for Secondary Adrenal Insufficiency

GO Terms for Secondary Adrenal Insufficiency

Cellular components related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP IGF1 IGFBP3 INS
2 extracellular region GO:0005576 9.55 AVP IGF1 IGFBP3 INS PGM1
3 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
4 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 AVP IGF1 INS
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IGF1 INS
3 positive regulation of cell growth GO:0030307 9.55 AVP INS
4 cellular protein metabolic process GO:0044267 9.54 IGF1 IGFBP3 INS
5 glucose metabolic process GO:0006006 9.52 INS PGM1
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.51 IGF1 INS
7 positive regulation of DNA replication GO:0045740 9.49 IGF1 INS
8 positive regulation of glucose import GO:0046326 9.48 IGF1 INS
9 ERK1 and ERK2 cascade GO:0070371 9.46 AVP IGF1
10 activation of protein kinase B activity GO:0032148 9.43 IGF1 INS
11 positive regulation of mitotic nuclear division GO:0045840 9.4 IGF1 INS
12 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.32 AVP IGF1
13 positive regulation of glycogen biosynthetic process GO:0045725 9.26 IGF1 INS
14 positive regulation of glycolytic process GO:0045821 9.16 IGF1 INS
15 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.96 IGF1 IGFBP3
16 positive regulation of MAPK cascade GO:0043410 8.8 IGF1 IGFBP3 INS

Molecular functions related to Secondary Adrenal Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 IGF1 INS
2 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS
3 hormone activity GO:0005179 8.8 AVP IGF1 INS

Sources for Secondary Adrenal Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
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70 UMLS via Orphanet
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